-- dump date   	20140619_055659
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1147129000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
1147129000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1147129000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147129000004	Walker A motif; other site
1147129000005	ATP binding site [chemical binding]; other site
1147129000006	Walker B motif; other site
1147129000007	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1147129000008	arginine finger; other site
1147129000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1147129000010	DnaA box-binding interface [nucleotide binding]; other site
1147129000011	DNA polymerase III subunit beta; Validated; Region: PRK05643
1147129000012	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1147129000013	putative DNA binding surface [nucleotide binding]; other site
1147129000014	dimer interface [polypeptide binding]; other site
1147129000015	beta-clamp/clamp loader binding surface; other site
1147129000016	beta-clamp/translesion DNA polymerase binding surface; other site
1147129000017	recombination protein F; Reviewed; Region: recF; PRK00064
1147129000018	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1147129000019	Walker A/P-loop; other site
1147129000020	ATP binding site [chemical binding]; other site
1147129000021	Q-loop/lid; other site
1147129000022	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1147129000023	ABC transporter signature motif; other site
1147129000024	Walker B; other site
1147129000025	D-loop; other site
1147129000026	H-loop/switch region; other site
1147129000027	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1147129000028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147129000029	ATP binding site [chemical binding]; other site
1147129000030	Mg2+ binding site [ion binding]; other site
1147129000031	G-X-G motif; other site
1147129000032	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1147129000033	anchoring element; other site
1147129000034	dimer interface [polypeptide binding]; other site
1147129000035	ATP binding site [chemical binding]; other site
1147129000036	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1147129000037	active site
1147129000038	putative metal-binding site [ion binding]; other site
1147129000039	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1147129000040	DNA gyrase subunit A; Validated; Region: PRK05560
1147129000041	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1147129000042	CAP-like domain; other site
1147129000043	active site
1147129000044	primary dimer interface [polypeptide binding]; other site
1147129000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1147129000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1147129000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1147129000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1147129000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1147129000050	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
1147129000051	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
1147129000052	active site
1147129000053	multimer interface [polypeptide binding]; other site
1147129000054	imidazole glycerol phosphate synthase subunit hisH; Provisional; Region: hisH; CHL00188
1147129000055	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
1147129000056	predicted active site [active]
1147129000057	catalytic triad [active]
1147129000058	seryl-tRNA synthetase; Provisional; Region: PRK05431
1147129000059	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1147129000060	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1147129000061	dimer interface [polypeptide binding]; other site
1147129000062	active site
1147129000063	motif 1; other site
1147129000064	motif 2; other site
1147129000065	motif 3; other site
1147129000066	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1147129000067	nucleoside/Zn binding site; other site
1147129000068	dimer interface [polypeptide binding]; other site
1147129000069	catalytic motif [active]
1147129000070	Helix-turn-helix domain; Region: HTH_17; cl17695
1147129000071	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1147129000072	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1147129000073	DNA binding residues [nucleotide binding]
1147129000074	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1147129000075	TrkA-N domain; Region: TrkA_N; pfam02254
1147129000076	TrkA-C domain; Region: TrkA_C; pfam02080
1147129000077	Cation transport protein; Region: TrkH; cl17365
1147129000078	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1147129000079	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1147129000080	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1147129000081	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
1147129000082	transmembrane helices; other site
1147129000083	sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547
1147129000084	putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827
1147129000085	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147129000086	Coenzyme A binding pocket [chemical binding]; other site
1147129000087	lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820
1147129000088	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147129000089	FeS/SAM binding site; other site
1147129000090	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
1147129000091	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147129000092	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
1147129000093	FeS/SAM binding site; other site
1147129000094	Peptidase family U32; Region: Peptidase_U32; cl03113
1147129000095	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1147129000096	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147129000097	FeS/SAM binding site; other site
1147129000098	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1147129000099	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147129000100	non-specific DNA binding site [nucleotide binding]; other site
1147129000101	salt bridge; other site
1147129000102	sequence-specific DNA binding site [nucleotide binding]; other site
1147129000103	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1147129000104	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1147129000105	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1147129000106	Walker A motif; other site
1147129000107	ATP binding site [chemical binding]; other site
1147129000108	Walker B motif; other site
1147129000109	AAA domain; Region: AAA_31; pfam13614
1147129000110	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1147129000111	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1147129000112	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1147129000113	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1147129000114	NlpC/P60 family; Region: NLPC_P60; cl17555
1147129000115	AAA-like domain; Region: AAA_10; pfam12846
1147129000116	Domain of unknown function DUF87; Region: DUF87; pfam01935
1147129000117	PrgI family protein; Region: PrgI; pfam12666
1147129000118	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147129000119	non-specific DNA binding site [nucleotide binding]; other site
1147129000120	salt bridge; other site
1147129000121	sequence-specific DNA binding site [nucleotide binding]; other site
1147129000122	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
1147129000123	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1147129000124	Walker A motif; other site
1147129000125	ATP binding site [chemical binding]; other site
1147129000126	Walker B motif; other site
1147129000127	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
1147129000128	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
1147129000129	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
1147129000130	Protein of unknown function (DUF3849); Region: DUF3849; pfam12960
1147129000131	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
1147129000132	AAA domain; Region: AAA_14; pfam13173
1147129000133	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1147129000134	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
1147129000135	putative DNA binding helix; other site
1147129000136	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
1147129000137	Toprim-like; Region: Toprim_2; pfam13155
1147129000138	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
1147129000139	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1147129000140	Transposase [DNA replication, recombination, and repair]; Region: COG5421
1147129000141	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
1147129000142	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1147129000143	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
1147129000144	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1147129000145	ParB-like nuclease domain; Region: ParB; smart00470
1147129000146	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1147129000147	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1147129000148	P-loop; other site
1147129000149	Magnesium ion binding site [ion binding]; other site
1147129000150	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1147129000151	Magnesium ion binding site [ion binding]; other site
1147129000152	Caspase domain; Region: Peptidase_C14; pfam00656
1147129000153	AAA domain; Region: AAA_23; pfam13476
1147129000154	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1147129000155	AAA domain; Region: AAA_21; pfam13304
1147129000156	Walker A/P-loop; other site
1147129000157	ATP binding site [chemical binding]; other site
1147129000158	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1147129000159	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1147129000160	P-loop; other site
1147129000161	Magnesium ion binding site [ion binding]; other site
1147129000162	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1147129000163	Magnesium ion binding site [ion binding]; other site
1147129000164	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
1147129000165	ParB-like nuclease domain; Region: ParB; smart00470
1147129000166	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
1147129000167	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1147129000168	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
1147129000169	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1147129000170	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
1147129000171	nucleotide binding region [chemical binding]; other site
1147129000172	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1147129000173	ATP-binding site [chemical binding]; other site
1147129000174	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
1147129000175	Toprim-like; Region: Toprim_2; pfam13155
1147129000176	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1147129000177	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
1147129000178	Protein of unknown function (DUF3849); Region: DUF3849; pfam12960
1147129000179	conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877
1147129000180	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
1147129000181	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
1147129000182	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
1147129000183	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
1147129000184	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
1147129000185	PrgI family protein; Region: PrgI; pfam12666
1147129000186	AAA-like domain; Region: AAA_10; pfam12846
1147129000187	Domain of unknown function DUF87; Region: DUF87; pfam01935
1147129000188	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1147129000189	NlpC/P60 family; Region: NLPC_P60; cl17555
1147129000190	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1147129000191	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
1147129000192	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1147129000193	AAA domain; Region: AAA_31; pfam13614
1147129000194	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1147129000195	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1147129000196	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1147129000197	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1147129000198	Walker A motif; other site
1147129000199	ATP binding site [chemical binding]; other site
1147129000200	Walker B motif; other site
1147129000201	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1147129000202	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1147129000203	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147129000204	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
1147129000205	FeS/SAM binding site; other site
1147129000206	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1147129000207	Peptidase family U32; Region: Peptidase_U32; cl03113
1147129000208	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147129000209	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1147129000210	FeS/SAM binding site; other site
1147129000211	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129000212	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129000213	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129000214	NlpC/P60 family; Region: NLPC_P60; cl17555
1147129000215	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
1147129000216	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1147129000217	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1147129000218	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
1147129000219	RNA polymerase sigma factor, SigZ family; Region: SigZ; TIGR02959
1147129000220	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1147129000221	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1147129000222	Domain of unknown function (DUF2703); Region: DUF2703; pfam10865
1147129000223	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1147129000224	dimerization interface [polypeptide binding]; other site
1147129000225	putative DNA binding site [nucleotide binding]; other site
1147129000226	putative Zn2+ binding site [ion binding]; other site
1147129000227	tungsten cofactor oxidoreducase radical SAM maturase; Region: W_rSAM_matur; TIGR04317
1147129000228	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147129000229	FeS/SAM binding site; other site
1147129000230	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
1147129000231	Predicted permease; Region: DUF318; cl17795
1147129000232	Predicted permease; Region: DUF318; cl17795
1147129000233	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1147129000234	dimerization interface [polypeptide binding]; other site
1147129000235	putative DNA binding site [nucleotide binding]; other site
1147129000236	putative Zn2+ binding site [ion binding]; other site
1147129000237	tungsten cofactor oxidoreducase radical SAM maturase; Region: W_rSAM_matur; TIGR04317
1147129000238	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147129000239	FeS/SAM binding site; other site
1147129000240	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
1147129000241	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1147129000242	putative DNA binding site [nucleotide binding]; other site
1147129000243	putative Zn2+ binding site [ion binding]; other site
1147129000244	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
1147129000245	arsenical-resistance protein; Region: acr3; TIGR00832
1147129000246	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1147129000247	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1147129000248	Low molecular weight phosphatase family; Region: LMWPc; cl00105
1147129000249	active site
1147129000250	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
1147129000251	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1147129000252	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1147129000253	Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953
1147129000254	arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291
1147129000255	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1147129000256	P loop; other site
1147129000257	Nucleotide binding site [chemical binding]; other site
1147129000258	DTAP/Switch II; other site
1147129000259	Switch I; other site
1147129000260	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1147129000261	P loop; other site
1147129000262	Nucleotide binding site [chemical binding]; other site
1147129000263	DTAP/Switch II; other site
1147129000264	Switch I; other site
1147129000265	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1147129000266	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1147129000267	putative DNA binding site [nucleotide binding]; other site
1147129000268	dimerization interface [polypeptide binding]; other site
1147129000269	putative Zn2+ binding site [ion binding]; other site
1147129000270	Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596
1147129000271	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
1147129000272	Predicted permeases [General function prediction only]; Region: COG0701
1147129000273	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1147129000274	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1147129000275	DNA binding residues [nucleotide binding]
1147129000276	Domain of unknown function (DUF2703); Region: DUF2703; pfam10865
1147129000277	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1147129000278	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
1147129000279	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1147129000280	Walker A/P-loop; other site
1147129000281	ATP binding site [chemical binding]; other site
1147129000282	Q-loop/lid; other site
1147129000283	ABC transporter signature motif; other site
1147129000284	Walker B; other site
1147129000285	D-loop; other site
1147129000286	H-loop/switch region; other site
1147129000287	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1147129000288	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147129000289	dimer interface [polypeptide binding]; other site
1147129000290	conserved gate region; other site
1147129000291	putative PBP binding loops; other site
1147129000292	ABC-ATPase subunit interface; other site
1147129000293	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
1147129000294	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1147129000295	Helix-turn-helix domain; Region: HTH_17; pfam12728
1147129000296	PBP superfamily domain; Region: PBP_like; pfam12727
1147129000297	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1147129000298	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1147129000299	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1147129000300	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1147129000301	dimerization interface [polypeptide binding]; other site
1147129000302	putative DNA binding site [nucleotide binding]; other site
1147129000303	putative Zn2+ binding site [ion binding]; other site
1147129000304	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
1147129000305	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1147129000306	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1147129000307	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1147129000308	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
1147129000309	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1147129000310	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
1147129000311	DGC domain; Region: DGC; pfam08859
1147129000312	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1147129000313	lipoyl attachment site [posttranslational modification]; other site
1147129000314	DGC domain; Region: DGC; cl01742
1147129000315	DGC domain; Region: DGC; cl01742
1147129000316	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
1147129000317	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1147129000318	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
1147129000319	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1147129000320	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1147129000321	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1147129000322	catalytic residues [active]
1147129000323	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1147129000324	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1147129000325	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1147129000326	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1147129000327	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1147129000328	catalytic residue [active]
1147129000329	Putative Fe-S cluster; Region: FeS; cl17515
1147129000330	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1147129000331	dimerization interface [polypeptide binding]; other site
1147129000332	putative DNA binding site [nucleotide binding]; other site
1147129000333	putative Zn2+ binding site [ion binding]; other site
1147129000334	DGC domain; Region: DGC; cl01742
1147129000335	DGC domain; Region: DGC; cl01742
1147129000336	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1147129000337	carboxyltransferase (CT) interaction site; other site
1147129000338	biotinylation site [posttranslational modification]; other site
1147129000339	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
1147129000340	lipoyl-biotinyl attachment site [posttranslational modification]; other site
1147129000341	lipoate-protein ligase A; Provisional; Region: lplA; PRK03822
1147129000342	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1147129000343	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1147129000344	tungsten cofactor oxidoreducase radical SAM maturase; Region: W_rSAM_matur; TIGR04317
1147129000345	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147129000346	FeS/SAM binding site; other site
1147129000347	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
1147129000348	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1147129000349	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147129000350	putative substrate translocation pore; other site
1147129000351	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1147129000352	Transposase [DNA replication, recombination, and repair]; Region: COG5421
1147129000353	hypothetical protein; Provisional; Region: PRK02947
1147129000354	Predicted permease; Region: DUF318; cl17795
1147129000355	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
1147129000356	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1147129000357	DNA binding residues [nucleotide binding]
1147129000358	Helix-turn-helix domain; Region: HTH_17; pfam12728
1147129000359	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1147129000360	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1147129000361	active site
1147129000362	DNA binding site [nucleotide binding]
1147129000363	Int/Topo IB signature motif; other site
1147129000364	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1147129000365	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147129000366	Walker A motif; other site
1147129000367	ATP binding site [chemical binding]; other site
1147129000368	Walker B motif; other site
1147129000369	arginine finger; other site
1147129000370	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
1147129000371	active site
1147129000372	catalytic triad [active]
1147129000373	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1147129000374	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1147129000375	metal binding site [ion binding]; metal-binding site
1147129000376	active site
1147129000377	I-site; other site
1147129000378	L-lactate permease; Region: Lactate_perm; cl00701
1147129000379	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1147129000380	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1147129000381	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
1147129000382	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147129000383	non-specific DNA binding site [nucleotide binding]; other site
1147129000384	salt bridge; other site
1147129000385	sequence-specific DNA binding site [nucleotide binding]; other site
1147129000386	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147129000387	non-specific DNA binding site [nucleotide binding]; other site
1147129000388	salt bridge; other site
1147129000389	sequence-specific DNA binding site [nucleotide binding]; other site
1147129000390	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
1147129000391	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1147129000392	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
1147129000393	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
1147129000394	putative active site [active]
1147129000395	putative metal binding site [ion binding]; other site
1147129000396	Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
1147129000397	putative metal binding residues [ion binding]; other site
1147129000398	signature motif; other site
1147129000399	dimer interface [polypeptide binding]; other site
1147129000400	active site
1147129000401	polyP binding site; other site
1147129000402	substrate binding site [chemical binding]; other site
1147129000403	acceptor-phosphate pocket; other site
1147129000404	CotH protein; Region: CotH; pfam08757
1147129000405	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1147129000406	HlyD family secretion protein; Region: HlyD_3; pfam13437
1147129000407	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1147129000408	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1147129000409	Walker A/P-loop; other site
1147129000410	ATP binding site [chemical binding]; other site
1147129000411	Q-loop/lid; other site
1147129000412	ABC transporter signature motif; other site
1147129000413	Walker B; other site
1147129000414	D-loop; other site
1147129000415	H-loop/switch region; other site
1147129000416	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1147129000417	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1147129000418	Walker A/P-loop; other site
1147129000419	ATP binding site [chemical binding]; other site
1147129000420	Q-loop/lid; other site
1147129000421	ABC transporter signature motif; other site
1147129000422	Walker B; other site
1147129000423	D-loop; other site
1147129000424	H-loop/switch region; other site
1147129000425	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1147129000426	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1147129000427	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1147129000428	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1147129000429	Winged helix-turn helix; Region: HTH_29; pfam13551
1147129000430	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
1147129000431	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147129000432	Walker A motif; other site
1147129000433	ATP binding site [chemical binding]; other site
1147129000434	Walker B motif; other site
1147129000435	arginine finger; other site
1147129000436	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1147129000437	hypothetical protein; Validated; Region: PRK00153
1147129000438	recombination protein RecR; Reviewed; Region: recR; PRK00076
1147129000439	RecR protein; Region: RecR; pfam02132
1147129000440	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1147129000441	putative active site [active]
1147129000442	putative metal-binding site [ion binding]; other site
1147129000443	tetramer interface [polypeptide binding]; other site
1147129000444	SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466
1147129000445	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
1147129000446	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1147129000447	dimer interface [polypeptide binding]; other site
1147129000448	PYR/PP interface [polypeptide binding]; other site
1147129000449	TPP binding site [chemical binding]; other site
1147129000450	substrate binding site [chemical binding]; other site
1147129000451	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1147129000452	Domain of unknown function; Region: EKR; smart00890
1147129000453	4Fe-4S binding domain; Region: Fer4_6; pfam12837
1147129000454	4Fe-4S binding domain; Region: Fer4; pfam00037
1147129000455	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
1147129000456	TPP-binding site [chemical binding]; other site
1147129000457	dimer interface [polypeptide binding]; other site
1147129000458	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1147129000459	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
1147129000460	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1147129000461	catalytic residue [active]
1147129000462	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1147129000463	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
1147129000464	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
1147129000465	Protein of unknown function (DUF972); Region: DUF972; pfam06156
1147129000466	Predicted methyltransferases [General function prediction only]; Region: COG0313
1147129000467	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1147129000468	putative SAM binding site [chemical binding]; other site
1147129000469	putative homodimer interface [polypeptide binding]; other site
1147129000470	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
1147129000471	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
1147129000472	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1147129000473	active site
1147129000474	KMSKS motif; other site
1147129000475	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1147129000476	tRNA binding surface [nucleotide binding]; other site
1147129000477	anticodon binding site; other site
1147129000478	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1147129000479	dimer interface [polypeptide binding]; other site
1147129000480	putative tRNA-binding site [nucleotide binding]; other site
1147129000481	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
1147129000482	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1147129000483	active site
1147129000484	Winged helix-turn helix; Region: HTH_29; pfam13551
1147129000485	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
1147129000486	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1147129000487	B12 binding site [chemical binding]; other site
1147129000488	Domain of unknown function (DUF3786); Region: DUF3786; pfam12654
1147129000489	Predicted RNA-binding protein; Region: RNA_bind_2; cl00662
1147129000490	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1147129000491	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
1147129000492	catalytic loop [active]
1147129000493	iron binding site [ion binding]; other site
1147129000494	bifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta; Reviewed; Region: PRK09529
1147129000495	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1147129000496	CODH interaction site; other site
1147129000497	metal cluster binding site [ion binding]; other site
1147129000498	CO dehydrogenase/acetyl-CoA synthase complex beta subunit; Region: CdhC; pfam03598
1147129000499	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
1147129000500	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
1147129000501	substrate binding pocket [chemical binding]; other site
1147129000502	dimer interface [polypeptide binding]; other site
1147129000503	inhibitor binding site; inhibition site
1147129000504	acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional; Region: PRK04165
1147129000505	Putative Fe-S cluster; Region: FeS; pfam04060
1147129000506	acetyl-CoA decarbonylase/synthase complex subunit delta; Provisional; Region: PRK04452
1147129000507	CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640
1147129000508	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
1147129000509	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
1147129000510	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
1147129000511	P-loop; other site
1147129000512	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1147129000513	carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702
1147129000514	Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915
1147129000515	ACS interaction site; other site
1147129000516	CODH interaction site; other site
1147129000517	cubane metal cluster (B-cluster) [ion binding]; other site
1147129000518	Ni-Fe-S cluster (C-cluster) [ion binding]; other site
1147129000519	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1147129000520	active site
1147129000521	methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535
1147129000522	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
1147129000523	substrate binding pocket [chemical binding]; other site
1147129000524	dimer interface [polypeptide binding]; other site
1147129000525	inhibitor binding site; inhibition site
1147129000526	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
1147129000527	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1147129000528	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1147129000529	homodimer interface [polypeptide binding]; other site
1147129000530	NADP binding site [chemical binding]; other site
1147129000531	substrate binding site [chemical binding]; other site
1147129000532	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
1147129000533	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
1147129000534	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
1147129000535	Potassium binding sites [ion binding]; other site
1147129000536	Cesium cation binding sites [ion binding]; other site
1147129000537	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
1147129000538	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1147129000539	FAD binding site [chemical binding]; other site
1147129000540	Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225
1147129000541	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1147129000542	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
1147129000543	catalytic loop [active]
1147129000544	iron binding site [ion binding]; other site
1147129000545	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1147129000546	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147129000547	DNA-binding site [nucleotide binding]; DNA binding site
1147129000548	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1147129000549	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
1147129000550	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
1147129000551	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1147129000552	glycerol kinase; Provisional; Region: glpK; PRK00047
1147129000553	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1147129000554	N- and C-terminal domain interface [polypeptide binding]; other site
1147129000555	active site
1147129000556	MgATP binding site [chemical binding]; other site
1147129000557	catalytic site [active]
1147129000558	metal binding site [ion binding]; metal-binding site
1147129000559	glycerol binding site [chemical binding]; other site
1147129000560	homotetramer interface [polypeptide binding]; other site
1147129000561	homodimer interface [polypeptide binding]; other site
1147129000562	FBP binding site [chemical binding]; other site
1147129000563	protein IIAGlc interface [polypeptide binding]; other site
1147129000564	Protein of unknown function DUF45; Region: DUF45; pfam01863
1147129000565	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
1147129000566	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
1147129000567	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
1147129000568	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
1147129000569	pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029
1147129000570	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
1147129000571	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1147129000572	dimer interface [polypeptide binding]; other site
1147129000573	PYR/PP interface [polypeptide binding]; other site
1147129000574	TPP binding site [chemical binding]; other site
1147129000575	substrate binding site [chemical binding]; other site
1147129000576	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
1147129000577	TPP-binding site; other site
1147129000578	4Fe-4S binding domain; Region: Fer4; pfam00037
1147129000579	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
1147129000580	hypothetical protein; Provisional; Region: PRK06851
1147129000581	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147129000582	Walker A motif; other site
1147129000583	ATP binding site [chemical binding]; other site
1147129000584	Divergent AAA domain; Region: AAA_4; pfam04326
1147129000585	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
1147129000586	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
1147129000587	putative active site [active]
1147129000588	putative metal binding site [ion binding]; other site
1147129000589	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
1147129000590	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1147129000591	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
1147129000592	YabG peptidase U57; Region: Peptidase_U57; cl05250
1147129000593	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
1147129000594	proposed catalytic triad [active]
1147129000595	active site nucleophile [active]
1147129000596	cyanophycin synthetase; Provisional; Region: PRK14016
1147129000597	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1147129000598	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1147129000599	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1147129000600	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
1147129000601	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1147129000602	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1147129000603	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1147129000604	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147129000605	DNA-binding site [nucleotide binding]; DNA binding site
1147129000606	FCD domain; Region: FCD; pfam07729
1147129000607	pur operon repressor; Provisional; Region: PRK09213
1147129000608	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
1147129000609	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1147129000610	active site
1147129000611	regulatory protein SpoVG; Reviewed; Region: PRK13259
1147129000612	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
1147129000613	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1147129000614	Substrate binding site; other site
1147129000615	Mg++ binding site; other site
1147129000616	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1147129000617	active site
1147129000618	substrate binding site [chemical binding]; other site
1147129000619	CoA binding site [chemical binding]; other site
1147129000620	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1147129000621	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1147129000622	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1147129000623	active site
1147129000624	Protein implicated in RNA metabolism, contains PRC-barrel domain [General    function prediction only]; Region: COG1873; cl17889
1147129000625	PRC-barrel domain; Region: PRC; pfam05239
1147129000626	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1147129000627	putative active site [active]
1147129000628	catalytic residue [active]
1147129000629	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1147129000630	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1147129000631	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1147129000632	ATP binding site [chemical binding]; other site
1147129000633	putative Mg++ binding site [ion binding]; other site
1147129000634	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1147129000635	nucleotide binding region [chemical binding]; other site
1147129000636	ATP-binding site [chemical binding]; other site
1147129000637	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1147129000638	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
1147129000639	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1147129000640	stage V sporulation protein T; Region: spore_V_T; TIGR02851
1147129000641	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
1147129000642	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
1147129000643	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
1147129000644	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1147129000645	homodimer interface [polypeptide binding]; other site
1147129000646	metal binding site [ion binding]; metal-binding site
1147129000647	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
1147129000648	homodimer interface [polypeptide binding]; other site
1147129000649	active site
1147129000650	putative chemical substrate binding site [chemical binding]; other site
1147129000651	metal binding site [ion binding]; metal-binding site
1147129000652	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1147129000653	IHF dimer interface [polypeptide binding]; other site
1147129000654	IHF - DNA interface [nucleotide binding]; other site
1147129000655	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
1147129000656	YabP family; Region: YabP; cl06766
1147129000657	Winged helix-turn helix; Region: HTH_29; pfam13551
1147129000658	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
1147129000659	DNA binding residues [nucleotide binding]
1147129000660	Septum formation initiator; Region: DivIC; pfam04977
1147129000661	stage II sporulation protein E; Region: spore_II_E; TIGR02865
1147129000662	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1147129000663	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1147129000664	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1147129000665	Ligand Binding Site [chemical binding]; other site
1147129000666	TilS substrate C-terminal domain; Region: TilS_C; smart00977
1147129000667	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1147129000668	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147129000669	Walker A motif; other site
1147129000670	ATP binding site [chemical binding]; other site
1147129000671	Walker B motif; other site
1147129000672	arginine finger; other site
1147129000673	Peptidase family M41; Region: Peptidase_M41; pfam01434
1147129000674	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1147129000675	active site
1147129000676	multimer interface [polypeptide binding]; other site
1147129000677	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
1147129000678	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
1147129000679	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
1147129000680	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1147129000681	dihydropteroate synthase; Region: DHPS; TIGR01496
1147129000682	substrate binding pocket [chemical binding]; other site
1147129000683	dimer interface [polypeptide binding]; other site
1147129000684	inhibitor binding site; inhibition site
1147129000685	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1147129000686	homooctamer interface [polypeptide binding]; other site
1147129000687	active site
1147129000688	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1147129000689	catalytic center binding site [active]
1147129000690	ATP binding site [chemical binding]; other site
1147129000691	Rossmann-like domain; Region: Rossmann-like; pfam10727
1147129000692	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
1147129000693	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1147129000694	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1147129000695	active site
1147129000696	ATP-binding site [chemical binding]; other site
1147129000697	pantoate-binding site; other site
1147129000698	HXXH motif; other site
1147129000699	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1147129000700	tetramerization interface [polypeptide binding]; other site
1147129000701	active site
1147129000702	Quinolinate synthetase A protein; Region: NadA; pfam02445
1147129000703	L-aspartate oxidase; Provisional; Region: PRK06175
1147129000704	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
1147129000705	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1147129000706	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
1147129000707	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1147129000708	dimerization interface [polypeptide binding]; other site
1147129000709	active site
1147129000710	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1147129000711	nucleotide binding site [chemical binding]; other site
1147129000712	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1147129000713	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1147129000714	FMN binding site [chemical binding]; other site
1147129000715	active site
1147129000716	catalytic residues [active]
1147129000717	substrate binding site [chemical binding]; other site
1147129000718	Winged helix-turn helix; Region: HTH_29; pfam13551
1147129000719	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1147129000720	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1147129000721	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1147129000722	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1147129000723	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1147129000724	dimer interface [polypeptide binding]; other site
1147129000725	putative anticodon binding site; other site
1147129000726	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1147129000727	motif 1; other site
1147129000728	active site
1147129000729	motif 2; other site
1147129000730	motif 3; other site
1147129000731	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1147129000732	dimerization interface [polypeptide binding]; other site
1147129000733	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1147129000734	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1147129000735	dimer interface [polypeptide binding]; other site
1147129000736	putative CheW interface [polypeptide binding]; other site
1147129000737	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
1147129000738	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
1147129000739	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1147129000740	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
1147129000741	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1147129000742	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1147129000743	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1147129000744	ATP binding site [chemical binding]; other site
1147129000745	Walker A motif; other site
1147129000746	hexamer interface [polypeptide binding]; other site
1147129000747	Walker B motif; other site
1147129000748	Response regulator receiver domain; Region: Response_reg; pfam00072
1147129000749	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129000750	active site
1147129000751	phosphorylation site [posttranslational modification]
1147129000752	intermolecular recognition site; other site
1147129000753	dimerization interface [polypeptide binding]; other site
1147129000754	AAA domain; Region: AAA_31; pfam13614
1147129000755	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1147129000756	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
1147129000757	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1147129000758	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
1147129000759	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
1147129000760	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
1147129000761	TadE-like protein; Region: TadE; pfam07811
1147129000762	Flp/Fap pilin component; Region: Flp_Fap; cl01585
1147129000763	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1147129000764	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1147129000765	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1147129000766	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1147129000767	tRNA 2-selenouridine synthase; Region: tRNA_sel_U_synt; TIGR03167
1147129000768	active site residue [active]
1147129000769	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
1147129000770	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147129000771	non-specific DNA binding site [nucleotide binding]; other site
1147129000772	salt bridge; other site
1147129000773	sequence-specific DNA binding site [nucleotide binding]; other site
1147129000774	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
1147129000775	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
1147129000776	hypothetical protein; Provisional; Region: PRK00955
1147129000777	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
1147129000778	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
1147129000779	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1147129000780	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147129000781	FeS/SAM binding site; other site
1147129000782	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
1147129000783	competence damage-inducible protein A; Provisional; Region: PRK00549
1147129000784	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1147129000785	putative MPT binding site; other site
1147129000786	Competence-damaged protein; Region: CinA; pfam02464
1147129000787	recombinase A; Provisional; Region: recA; PRK09354
1147129000788	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1147129000789	hexamer interface [polypeptide binding]; other site
1147129000790	Walker A motif; other site
1147129000791	ATP binding site [chemical binding]; other site
1147129000792	Walker B motif; other site
1147129000793	recombination regulator RecX; Reviewed; Region: recX; PRK00117
1147129000794	phosphodiesterase; Provisional; Region: PRK12704
1147129000795	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1147129000796	Zn2+ binding site [ion binding]; other site
1147129000797	Mg2+ binding site [ion binding]; other site
1147129000798	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
1147129000799	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1147129000800	putative active site [active]
1147129000801	metal binding site [ion binding]; metal-binding site
1147129000802	homodimer binding site [polypeptide binding]; other site
1147129000803	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
1147129000804	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
1147129000805	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
1147129000806	active site
1147129000807	dimer interface [polypeptide binding]; other site
1147129000808	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
1147129000809	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1147129000810	active site
1147129000811	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1147129000812	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
1147129000813	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1147129000814	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147129000815	homodimer interface [polypeptide binding]; other site
1147129000816	catalytic residue [active]
1147129000817	HDOD domain; Region: HDOD; pfam08668
1147129000818	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1147129000819	PhoU domain; Region: PhoU; pfam01895
1147129000820	PhoU domain; Region: PhoU; pfam01895
1147129000821	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
1147129000822	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1147129000823	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147129000824	Coenzyme A binding pocket [chemical binding]; other site
1147129000825	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
1147129000826	RNA/DNA hybrid binding site [nucleotide binding]; other site
1147129000827	active site
1147129000828	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1147129000829	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1147129000830	Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074
1147129000831	CoA binding domain; Region: CoA_binding; smart00881
1147129000832	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
1147129000833	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1147129000834	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
1147129000835	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1147129000836	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1147129000837	putative NAD(P) binding site [chemical binding]; other site
1147129000838	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1147129000839	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1147129000840	putative active site [active]
1147129000841	putative NTP binding site [chemical binding]; other site
1147129000842	putative nucleic acid binding site [nucleotide binding]; other site
1147129000843	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1147129000844	PAS domain S-box; Region: sensory_box; TIGR00229
1147129000845	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1147129000846	putative active site [active]
1147129000847	heme pocket [chemical binding]; other site
1147129000848	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1147129000849	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1147129000850	metal binding site [ion binding]; metal-binding site
1147129000851	active site
1147129000852	I-site; other site
1147129000853	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
1147129000854	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1147129000855	Zn2+ binding site [ion binding]; other site
1147129000856	Mg2+ binding site [ion binding]; other site
1147129000857	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
1147129000858	GAF domain; Region: GAF_3; pfam13492
1147129000859	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1147129000860	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1147129000861	dimer interface [polypeptide binding]; other site
1147129000862	phosphorylation site [posttranslational modification]
1147129000863	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147129000864	ATP binding site [chemical binding]; other site
1147129000865	Mg2+ binding site [ion binding]; other site
1147129000866	G-X-G motif; other site
1147129000867	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
1147129000868	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129000869	active site
1147129000870	phosphorylation site [posttranslational modification]
1147129000871	intermolecular recognition site; other site
1147129000872	dimerization interface [polypeptide binding]; other site
1147129000873	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1147129000874	DNA binding site [nucleotide binding]
1147129000875	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1147129000876	K+ potassium transporter; Region: K_trans; cl15781
1147129000877	spore photoproduct lyase; Region: photo_TT_lyase; cl15393
1147129000878	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
1147129000879	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
1147129000880	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
1147129000881	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1147129000882	ATP binding site [chemical binding]; other site
1147129000883	putative Mg++ binding site [ion binding]; other site
1147129000884	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1147129000885	nucleotide binding region [chemical binding]; other site
1147129000886	ATP-binding site [chemical binding]; other site
1147129000887	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
1147129000888	Late competence development protein ComFB; Region: ComFB; pfam10719
1147129000889	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1147129000890	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1147129000891	Walker A/P-loop; other site
1147129000892	ATP binding site [chemical binding]; other site
1147129000893	Q-loop/lid; other site
1147129000894	ABC transporter signature motif; other site
1147129000895	Walker B; other site
1147129000896	D-loop; other site
1147129000897	H-loop/switch region; other site
1147129000898	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1147129000899	NMT1/THI5 like; Region: NMT1; pfam09084
1147129000900	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1147129000901	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147129000902	ABC-ATPase subunit interface; other site
1147129000903	putative PBP binding loops; other site
1147129000904	Domain of unknown function DUF77; Region: DUF77; pfam01910
1147129000905	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1147129000906	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147129000907	S-adenosylmethionine binding site [chemical binding]; other site
1147129000908	FOG: CBS domain [General function prediction only]; Region: COG0517
1147129000909	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
1147129000910	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1147129000911	methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370
1147129000912	B12 binding site [chemical binding]; other site
1147129000913	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
1147129000914	Uncharacterized conserved protein [Function unknown]; Region: COG1739
1147129000915	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1147129000916	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1147129000917	TadE-like protein; Region: TadE; pfam07811
1147129000918	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
1147129000919	TadE-like protein; Region: TadE; pfam07811
1147129000920	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
1147129000921	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
1147129000922	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1147129000923	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1147129000924	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
1147129000925	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
1147129000926	PRC-barrel domain; Region: PRC; pfam05239
1147129000927	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1147129000928	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1147129000929	minor groove reading motif; other site
1147129000930	helix-hairpin-helix signature motif; other site
1147129000931	substrate binding pocket [chemical binding]; other site
1147129000932	active site
1147129000933	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1147129000934	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
1147129000935	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
1147129000936	active site
1147129000937	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
1147129000938	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
1147129000939	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147129000940	catalytic residue [active]
1147129000941	acetyl-CoA synthetase; Provisional; Region: PRK00174
1147129000942	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
1147129000943	active site
1147129000944	CoA binding site [chemical binding]; other site
1147129000945	acyl-activating enzyme (AAE) consensus motif; other site
1147129000946	AMP binding site [chemical binding]; other site
1147129000947	acetate binding site [chemical binding]; other site
1147129000948	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
1147129000949	putative active site; other site
1147129000950	putative metal binding residues [ion binding]; other site
1147129000951	signature motif; other site
1147129000952	putative triphosphate binding site [ion binding]; other site
1147129000953	oligoendopeptidase F; Region: pepF; TIGR00181
1147129000954	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
1147129000955	active site
1147129000956	Zn binding site [ion binding]; other site
1147129000957	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
1147129000958	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1147129000959	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
1147129000960	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
1147129000961	homotetramer interface [polypeptide binding]; other site
1147129000962	ligand binding site [chemical binding]; other site
1147129000963	catalytic site [active]
1147129000964	NAD binding site [chemical binding]; other site
1147129000965	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147129000966	Coenzyme A binding pocket [chemical binding]; other site
1147129000967	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
1147129000968	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
1147129000969	Plant protein of unknown function (DUF641); Region: DUF641; pfam04859
1147129000970	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1147129000971	Peptidase family M23; Region: Peptidase_M23; pfam01551
1147129000972	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1147129000973	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1147129000974	GIY-YIG motif/motif A; other site
1147129000975	active site
1147129000976	catalytic site [active]
1147129000977	putative DNA binding site [nucleotide binding]; other site
1147129000978	metal binding site [ion binding]; metal-binding site
1147129000979	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1147129000980	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
1147129000981	DNA binding site [nucleotide binding]
1147129000982	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1147129000983	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1147129000984	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1147129000985	active site
1147129000986	metal binding site [ion binding]; metal-binding site
1147129000987	homotetramer interface [polypeptide binding]; other site
1147129000988	Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651
1147129000989	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1147129000990	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1147129000991	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1147129000992	metal binding site [ion binding]; metal-binding site
1147129000993	active site
1147129000994	I-site; other site
1147129000995	recombination factor protein RarA; Reviewed; Region: PRK13342
1147129000996	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147129000997	Walker A motif; other site
1147129000998	ATP binding site [chemical binding]; other site
1147129000999	Walker B motif; other site
1147129001000	arginine finger; other site
1147129001001	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1147129001002	Rrf2 family protein; Region: rrf2_super; TIGR00738
1147129001003	Transcriptional regulator; Region: Rrf2; cl17282
1147129001004	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1147129001005	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1147129001006	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1147129001007	catalytic residue [active]
1147129001008	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1147129001009	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1147129001010	trimerization site [polypeptide binding]; other site
1147129001011	active site
1147129001012	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
1147129001013	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1147129001014	Ligand Binding Site [chemical binding]; other site
1147129001015	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
1147129001016	PRC-barrel domain; Region: PRC; pfam05239
1147129001017	reverse gyrase; Provisional; Region: PRK14701
1147129001018	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1147129001019	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1147129001020	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1147129001021	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1147129001022	motif 1; other site
1147129001023	active site
1147129001024	motif 2; other site
1147129001025	motif 3; other site
1147129001026	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1147129001027	DHHA1 domain; Region: DHHA1; pfam02272
1147129001028	hypothetical protein; Provisional; Region: PRK05473
1147129001029	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1147129001030	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1147129001031	active site
1147129001032	catalytic tetrad [active]
1147129001033	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1147129001034	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1147129001035	Predicted ATP-dependent serine protease [Posttranslational modification, protein turnover, chaperones]; Region: Sms; COG1066
1147129001036	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
1147129001037	YceG-like family; Region: YceG; pfam02618
1147129001038	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1147129001039	dimerization interface [polypeptide binding]; other site
1147129001040	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1147129001041	Peptidase family U32; Region: Peptidase_U32; pfam01136
1147129001042	type IV pilus assembly protein PilM; Region: pilM; TIGR01175
1147129001043	sporulation sigma factor SigK; Reviewed; Region: PRK05803
1147129001044	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1147129001045	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1147129001046	DNA binding residues [nucleotide binding]
1147129001047	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
1147129001048	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1147129001049	active site
1147129001050	motif I; other site
1147129001051	motif II; other site
1147129001052	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1147129001053	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1147129001054	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1147129001055	shikimate binding site; other site
1147129001056	NAD(P) binding site [chemical binding]; other site
1147129001057	shikimate kinase; Reviewed; Region: aroK; PRK00131
1147129001058	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1147129001059	ADP binding site [chemical binding]; other site
1147129001060	magnesium binding site [ion binding]; other site
1147129001061	putative shikimate binding site; other site
1147129001062	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1147129001063	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
1147129001064	active site
1147129001065	dimer interface [polypeptide binding]; other site
1147129001066	metal binding site [ion binding]; metal-binding site
1147129001067	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
1147129001068	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
1147129001069	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
1147129001070	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
1147129001071	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
1147129001072	Walker A motif; other site
1147129001073	ATP binding site [chemical binding]; other site
1147129001074	Walker B motif; other site
1147129001075	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
1147129001076	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1147129001077	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1147129001078	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
1147129001079	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1147129001080	active site
1147129001081	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
1147129001082	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1147129001083	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147129001084	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1147129001085	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1147129001086	trimer interface [polypeptide binding]; other site
1147129001087	active site
1147129001088	dimer interface [polypeptide binding]; other site
1147129001089	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1147129001090	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1147129001091	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1147129001092	active site
1147129001093	elongation factor P; Validated; Region: PRK00529
1147129001094	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1147129001095	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1147129001096	RNA binding site [nucleotide binding]; other site
1147129001097	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1147129001098	RNA binding site [nucleotide binding]; other site
1147129001099	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147129001100	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1147129001101	Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858
1147129001102	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147129001103	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147129001104	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
1147129001105	active site
1147129001106	stage III sporulation protein AA; Region: spore_III_AA; TIGR02858
1147129001107	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1147129001108	Walker A motif; other site
1147129001109	ATP binding site [chemical binding]; other site
1147129001110	Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022
1147129001111	stage III sporulation protein AC; Region: spore_III_AC; TIGR02848
1147129001112	Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961
1147129001113	Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546
1147129001114	Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581
1147129001115	stage III sporulation protein AG; Region: spore_III_AG; TIGR02830
1147129001116	SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685
1147129001117	Asp23 family; Region: Asp23; pfam03780
1147129001118	Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031
1147129001119	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
1147129001120	putative RNA binding site [nucleotide binding]; other site
1147129001121	Metal-dependent proteases with possible chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: QRI7; COG0533
1147129001122	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1147129001123	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1147129001124	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
1147129001125	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
1147129001126	FAD binding pocket [chemical binding]; other site
1147129001127	FAD binding motif [chemical binding]; other site
1147129001128	phosphate binding motif [ion binding]; other site
1147129001129	beta-alpha-beta structure motif; other site
1147129001130	NAD binding pocket [chemical binding]; other site
1147129001131	Iron coordination center [ion binding]; other site
1147129001132	putative oxidoreductase; Provisional; Region: PRK12831
1147129001133	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1147129001134	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
1147129001135	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
1147129001136	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1147129001137	Cl binding site [ion binding]; other site
1147129001138	oligomer interface [polypeptide binding]; other site
1147129001139	Uncharacterized protein containing a ferredoxin domain [Function unknown]; Region: COG4739
1147129001140	Uncharacterized protein containing a ferredoxin domain (DUF2148); Region: DUF2148; pfam09918
1147129001141	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1147129001142	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1147129001143	generic binding surface II; other site
1147129001144	generic binding surface I; other site
1147129001145	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
1147129001146	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1147129001147	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1147129001148	substrate binding pocket [chemical binding]; other site
1147129001149	chain length determination region; other site
1147129001150	substrate-Mg2+ binding site; other site
1147129001151	catalytic residues [active]
1147129001152	aspartate-rich region 1; other site
1147129001153	active site lid residues [active]
1147129001154	aspartate-rich region 2; other site
1147129001155	Divergent PAP2 family; Region: DUF212; pfam02681
1147129001156	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
1147129001157	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1147129001158	TPP-binding site; other site
1147129001159	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1147129001160	PYR/PP interface [polypeptide binding]; other site
1147129001161	dimer interface [polypeptide binding]; other site
1147129001162	TPP binding site [chemical binding]; other site
1147129001163	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1147129001164	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1147129001165	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1147129001166	RNA binding surface [nucleotide binding]; other site
1147129001167	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147129001168	S-adenosylmethionine binding site [chemical binding]; other site
1147129001169	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1147129001170	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
1147129001171	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1147129001172	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1147129001173	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
1147129001174	Arginine repressor [Transcription]; Region: ArgR; COG1438
1147129001175	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1147129001176	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1147129001177	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1147129001178	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1147129001179	Walker A/P-loop; other site
1147129001180	ATP binding site [chemical binding]; other site
1147129001181	Q-loop/lid; other site
1147129001182	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1147129001183	ABC transporter signature motif; other site
1147129001184	Walker B; other site
1147129001185	D-loop; other site
1147129001186	H-loop/switch region; other site
1147129001187	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
1147129001188	stage IV sporulation protein B; Region: spore_IV_B; TIGR02860
1147129001189	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
1147129001190	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
1147129001191	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
1147129001192	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129001193	active site
1147129001194	phosphorylation site [posttranslational modification]
1147129001195	intermolecular recognition site; other site
1147129001196	dimerization interface [polypeptide binding]; other site
1147129001197	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
1147129001198	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
1147129001199	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1147129001200	dimer interface [polypeptide binding]; other site
1147129001201	ADP-ribose binding site [chemical binding]; other site
1147129001202	active site
1147129001203	nudix motif; other site
1147129001204	metal binding site [ion binding]; metal-binding site
1147129001205	Integral membrane protein DUF95; Region: DUF95; cl00572
1147129001206	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1147129001207	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1147129001208	active site
1147129001209	DNA binding site [nucleotide binding]
1147129001210	Int/Topo IB signature motif; other site
1147129001211	phosphopentomutase; Provisional; Region: PRK05362
1147129001212	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
1147129001213	purine nucleoside phosphorylase; Provisional; Region: PRK08202
1147129001214	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1147129001215	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
1147129001216	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1147129001217	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
1147129001218	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1147129001219	CoA binding domain; Region: CoA_binding_2; pfam13380
1147129001220	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1147129001221	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1147129001222	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
1147129001223	sporulation sigma factor SigF; Validated; Region: PRK05572
1147129001224	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1147129001225	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1147129001226	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1147129001227	DNA binding residues [nucleotide binding]
1147129001228	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1147129001229	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147129001230	ATP binding site [chemical binding]; other site
1147129001231	Mg2+ binding site [ion binding]; other site
1147129001232	G-X-G motif; other site
1147129001233	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1147129001234	anti sigma factor interaction site; other site
1147129001235	regulatory phosphorylation site [posttranslational modification]; other site
1147129001236	SpoVA protein; Region: SpoVA; cl04298
1147129001237	stage V sporulation protein AD; Validated; Region: PRK08304
1147129001238	stage V sporulation protein AD; Provisional; Region: PRK12404
1147129001239	SpoVA protein; Region: SpoVA; cl04298
1147129001240	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1147129001241	hydrogenase 4 subunit B; Validated; Region: PRK06459
1147129001242	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1147129001243	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147129001244	Coenzyme A binding pocket [chemical binding]; other site
1147129001245	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1147129001246	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147129001247	Coenzyme A binding pocket [chemical binding]; other site
1147129001248	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1147129001249	putative active site [active]
1147129001250	Protein of unknown function (DUF3102); Region: DUF3102; pfam11300
1147129001251	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1147129001252	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1147129001253	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1147129001254	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129001255	active site
1147129001256	phosphorylation site [posttranslational modification]
1147129001257	intermolecular recognition site; other site
1147129001258	dimerization interface [polypeptide binding]; other site
1147129001259	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1147129001260	DNA binding residues [nucleotide binding]
1147129001261	dimerization interface [polypeptide binding]; other site
1147129001262	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1147129001263	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1147129001264	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1147129001265	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
1147129001266	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1147129001267	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
1147129001268	Walker A/P-loop; other site
1147129001269	ATP binding site [chemical binding]; other site
1147129001270	Q-loop/lid; other site
1147129001271	ABC transporter signature motif; other site
1147129001272	Walker B; other site
1147129001273	D-loop; other site
1147129001274	H-loop/switch region; other site
1147129001275	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1147129001276	Bacterial SH3 domain; Region: SH3_3; cl17532
1147129001277	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
1147129001278	active site
1147129001279	Zn binding site [ion binding]; other site
1147129001280	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129001281	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1147129001282	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1147129001283	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1147129001284	DNA binding residues [nucleotide binding]
1147129001285	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
1147129001286	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1147129001287	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
1147129001288	transmembrane helices; other site
1147129001289	Archaeal flagella assembly protein J [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlaJ; COG1955
1147129001290	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1147129001291	DHH family; Region: DHH; pfam01368
1147129001292	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1147129001293	FOG: CBS domain [General function prediction only]; Region: COG0517
1147129001294	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595
1147129001295	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
1147129001296	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1147129001297	active site
1147129001298	NTP binding site [chemical binding]; other site
1147129001299	metal binding triad [ion binding]; metal-binding site
1147129001300	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
1147129001301	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1147129001302	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1147129001303	active site
1147129001304	HIGH motif; other site
1147129001305	dimer interface [polypeptide binding]; other site
1147129001306	KMSKS motif; other site
1147129001307	ScpA/B protein; Region: ScpA_ScpB; cl00598
1147129001308	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
1147129001309	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
1147129001310	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1147129001311	active site
1147129001312	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1147129001313	substrate binding site [chemical binding]; other site
1147129001314	catalytic residues [active]
1147129001315	dimer interface [polypeptide binding]; other site
1147129001316	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1147129001317	Domain of unknown function (DUF4363); Region: DUF4363; pfam14276
1147129001318	Predicted membrane protein [Function unknown]; Region: COG2323
1147129001319	plasmid segregation protein ParM; Provisional; Region: PRK13917
1147129001320	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
1147129001321	Mg binding site [ion binding]; other site
1147129001322	nucleotide binding site [chemical binding]; other site
1147129001323	putative protofilament interface [polypeptide binding]; other site
1147129001324	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1147129001325	active site
1147129001326	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
1147129001327	dimer interface [polypeptide binding]; other site
1147129001328	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1147129001329	Ligand Binding Site [chemical binding]; other site
1147129001330	Molecular Tunnel; other site
1147129001331	anthranilate synthase; Provisional; Region: PRK13566
1147129001332	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1147129001333	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1147129001334	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1147129001335	glutamine binding [chemical binding]; other site
1147129001336	catalytic triad [active]
1147129001337	4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944
1147129001338	active site
1147129001339	catalytic residues [active]
1147129001340	metal binding site [ion binding]; metal-binding site
1147129001341	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1147129001342	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1147129001343	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147129001344	catalytic residue [active]
1147129001345	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
1147129001346	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1147129001347	substrate binding site [chemical binding]; other site
1147129001348	active site
1147129001349	catalytic residues [active]
1147129001350	heterodimer interface [polypeptide binding]; other site
1147129001351	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1147129001352	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1147129001353	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1147129001354	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1147129001355	active site
1147129001356	ribulose/triose binding site [chemical binding]; other site
1147129001357	phosphate binding site [ion binding]; other site
1147129001358	substrate (anthranilate) binding pocket [chemical binding]; other site
1147129001359	product (indole) binding pocket [chemical binding]; other site
1147129001360	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1147129001361	active site
1147129001362	60Kd inner membrane protein; Region: 60KD_IMP; pfam02096
1147129001363	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1147129001364	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1147129001365	putative active site [active]
1147129001366	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1147129001367	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959
1147129001368	NodB motif; other site
1147129001369	putative active site [active]
1147129001370	putative catalytic site [active]
1147129001371	putative Zn binding site [ion binding]; other site
1147129001372	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707
1147129001373	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
1147129001374	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
1147129001375	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1147129001376	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
1147129001377	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
1147129001378	KMSKS motif; other site
1147129001379	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
1147129001380	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1147129001381	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1147129001382	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1147129001383	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1147129001384	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
1147129001385	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1147129001386	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1147129001387	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1147129001388	metal binding site [ion binding]; metal-binding site
1147129001389	dimer interface [polypeptide binding]; other site
1147129001390	CAAX protease self-immunity; Region: Abi; pfam02517
1147129001391	Chromate transporter; Region: Chromate_transp; pfam02417
1147129001392	Chromate transporter; Region: Chromate_transp; pfam02417
1147129001393	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1147129001394	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1147129001395	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1147129001396	DNA binding residues [nucleotide binding]
1147129001397	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
1147129001398	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
1147129001399	reductive dehalogenase; Region: RDH; TIGR02486
1147129001400	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
1147129001401	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1147129001402	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1147129001403	ligand binding site [chemical binding]; other site
1147129001404	flexible hinge region; other site
1147129001405	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1147129001406	non-specific DNA interactions [nucleotide binding]; other site
1147129001407	DNA binding site [nucleotide binding]
1147129001408	sequence specific DNA binding site [nucleotide binding]; other site
1147129001409	putative cAMP binding site [chemical binding]; other site
1147129001410	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1147129001411	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1147129001412	putative active site [active]
1147129001413	putative NTP binding site [chemical binding]; other site
1147129001414	putative nucleic acid binding site [nucleotide binding]; other site
1147129001415	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
1147129001416	Predicted membrane protein [Function unknown]; Region: COG3462
1147129001417	Short C-terminal domain; Region: SHOCT; pfam09851
1147129001418	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1147129001419	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1147129001420	chaperone protein DnaJ; Provisional; Region: PRK14299
1147129001421	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1147129001422	HSP70 interaction site [polypeptide binding]; other site
1147129001423	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1147129001424	substrate binding site [polypeptide binding]; other site
1147129001425	dimer interface [polypeptide binding]; other site
1147129001426	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1147129001427	Clp amino terminal domain; Region: Clp_N; pfam02861
1147129001428	Clp amino terminal domain; Region: Clp_N; pfam02861
1147129001429	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147129001430	Walker A motif; other site
1147129001431	ATP binding site [chemical binding]; other site
1147129001432	Walker B motif; other site
1147129001433	arginine finger; other site
1147129001434	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147129001435	Walker A motif; other site
1147129001436	ATP binding site [chemical binding]; other site
1147129001437	Walker B motif; other site
1147129001438	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1147129001439	Coat F domain; Region: Coat_F; cl17715
1147129001440	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1147129001441	homopentamer interface [polypeptide binding]; other site
1147129001442	active site
1147129001443	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
1147129001444	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1147129001445	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1147129001446	dimerization interface [polypeptide binding]; other site
1147129001447	active site
1147129001448	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1147129001449	Lumazine binding domain; Region: Lum_binding; pfam00677
1147129001450	Lumazine binding domain; Region: Lum_binding; pfam00677
1147129001451	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1147129001452	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1147129001453	catalytic motif [active]
1147129001454	Zn binding site [ion binding]; other site
1147129001455	RibD C-terminal domain; Region: RibD_C; cl17279
1147129001456	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1147129001457	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1147129001458	Protein of unknown function (DUF975); Region: DUF975; cl10504
1147129001459	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1147129001460	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1147129001461	non-specific DNA interactions [nucleotide binding]; other site
1147129001462	DNA binding site [nucleotide binding]
1147129001463	sequence specific DNA binding site [nucleotide binding]; other site
1147129001464	putative cAMP binding site [chemical binding]; other site
1147129001465	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1147129001466	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1147129001467	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1147129001468	Predicted permeases [General function prediction only]; Region: COG0701
1147129001469	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
1147129001470	Sensor protein DegS; Region: DegS; pfam05384
1147129001471	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1147129001472	Histidine kinase; Region: HisKA_3; pfam07730
1147129001473	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147129001474	ATP binding site [chemical binding]; other site
1147129001475	Mg2+ binding site [ion binding]; other site
1147129001476	G-X-G motif; other site
1147129001477	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1147129001478	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129001479	active site
1147129001480	phosphorylation site [posttranslational modification]
1147129001481	intermolecular recognition site; other site
1147129001482	dimerization interface [polypeptide binding]; other site
1147129001483	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1147129001484	DNA binding residues [nucleotide binding]
1147129001485	dimerization interface [polypeptide binding]; other site
1147129001486	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
1147129001487	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1147129001488	Beta-Casp domain; Region: Beta-Casp; smart01027
1147129001489	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1147129001490	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1147129001491	Zn2+ binding site [ion binding]; other site
1147129001492	Mg2+ binding site [ion binding]; other site
1147129001493	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
1147129001494	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1147129001495	hypothetical protein; Validated; Region: PRK08116
1147129001496	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147129001497	Walker A motif; other site
1147129001498	ATP binding site [chemical binding]; other site
1147129001499	Walker B motif; other site
1147129001500	Transglutaminase family, C-terminal ig like domain; Region: Transglut_C; pfam00927
1147129001501	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
1147129001502	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
1147129001503	Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632
1147129001504	Uncharacterized conserved protein [Function unknown]; Region: COG1633
1147129001505	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1147129001506	dinuclear metal binding motif [ion binding]; other site
1147129001507	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1147129001508	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1147129001509	Uncharacterized conserved protein [Function unknown]; Region: COG1615
1147129001510	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
1147129001511	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1147129001512	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1147129001513	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1147129001514	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1147129001515	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147129001516	Rhomboid family; Region: Rhomboid; pfam01694
1147129001517	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
1147129001518	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1147129001519	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1147129001520	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
1147129001521	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1147129001522	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
1147129001523	oligomer interface [polypeptide binding]; other site
1147129001524	active site
1147129001525	metal binding site [ion binding]; metal-binding site
1147129001526	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1147129001527	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
1147129001528	oligomer interface [polypeptide binding]; other site
1147129001529	active site
1147129001530	metal binding site [ion binding]; metal-binding site
1147129001531	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1147129001532	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
1147129001533	oligomer interface [polypeptide binding]; other site
1147129001534	active site
1147129001535	metal binding site [ion binding]; metal-binding site
1147129001536	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
1147129001537	AIR carboxylase; Region: AIRC; smart01001
1147129001538	Predicted membrane protein [Function unknown]; Region: COG4905
1147129001539	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
1147129001540	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
1147129001541	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1147129001542	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1147129001543	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1147129001544	pyruvate kinase; Provisional; Region: PRK06354
1147129001545	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1147129001546	domain interfaces; other site
1147129001547	active site
1147129001548	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
1147129001549	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1147129001550	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147129001551	DNA-binding site [nucleotide binding]; DNA binding site
1147129001552	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1147129001553	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1147129001554	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
1147129001555	P-loop; other site
1147129001556	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
1147129001557	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147129001558	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1147129001559	G5 domain; Region: G5; pfam07501
1147129001560	Peptidase family M23; Region: Peptidase_M23; pfam01551
1147129001561	EDD domain protein, DegV family; Region: DegV; TIGR00762
1147129001562	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1147129001563	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328
1147129001564	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1147129001565	TRAM domain; Region: TRAM; pfam01938
1147129001566	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1147129001567	MutS domain I; Region: MutS_I; pfam01624
1147129001568	MutS domain II; Region: MutS_II; pfam05188
1147129001569	MutS domain III; Region: MutS_III; pfam05192
1147129001570	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1147129001571	Walker A/P-loop; other site
1147129001572	ATP binding site [chemical binding]; other site
1147129001573	Q-loop/lid; other site
1147129001574	ABC transporter signature motif; other site
1147129001575	Walker B; other site
1147129001576	D-loop; other site
1147129001577	H-loop/switch region; other site
1147129001578	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
1147129001579	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1147129001580	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1147129001581	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
1147129001582	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
1147129001583	active site
1147129001584	Zn binding site [ion binding]; other site
1147129001585	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
1147129001586	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147129001587	ATP binding site [chemical binding]; other site
1147129001588	Mg2+ binding site [ion binding]; other site
1147129001589	G-X-G motif; other site
1147129001590	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
1147129001591	ATP binding site [chemical binding]; other site
1147129001592	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
1147129001593	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
1147129001594	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1147129001595	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1147129001596	bacterial Hfq-like; Region: Hfq; cd01716
1147129001597	hexamer interface [polypeptide binding]; other site
1147129001598	Sm1 motif; other site
1147129001599	RNA binding site [nucleotide binding]; other site
1147129001600	Sm2 motif; other site
1147129001601	stage V sporulation protein K; Region: spore_V_K; TIGR02881
1147129001602	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147129001603	Walker A motif; other site
1147129001604	ATP binding site [chemical binding]; other site
1147129001605	Walker B motif; other site
1147129001606	arginine finger; other site
1147129001607	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
1147129001608	Aluminium resistance protein; Region: Alum_res; pfam06838
1147129001609	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1147129001610	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1147129001611	Catalytic site [active]
1147129001612	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1147129001613	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1147129001614	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
1147129001615	LexA repressor; Validated; Region: PRK00215
1147129001616	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1147129001617	putative DNA binding site [nucleotide binding]; other site
1147129001618	putative Zn2+ binding site [ion binding]; other site
1147129001619	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1147129001620	Catalytic site [active]
1147129001621	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
1147129001622	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1147129001623	Peptidase family M23; Region: Peptidase_M23; pfam01551
1147129001624	Predicted metal-binding protein (DUF2284); Region: DUF2284; pfam10050
1147129001625	Protein of unknown function (DUF3832); Region: DUF3832; pfam12909
1147129001626	EDD domain protein, DegV family; Region: DegV; TIGR00762
1147129001627	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1147129001628	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
1147129001629	Amidinotransferase; Region: Amidinotransf; cl12043
1147129001630	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1147129001631	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1147129001632	FtsX-like permease family; Region: FtsX; pfam02687
1147129001633	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1147129001634	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1147129001635	Walker A/P-loop; other site
1147129001636	ATP binding site [chemical binding]; other site
1147129001637	Q-loop/lid; other site
1147129001638	ABC transporter signature motif; other site
1147129001639	Walker B; other site
1147129001640	D-loop; other site
1147129001641	H-loop/switch region; other site
1147129001642	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
1147129001643	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1147129001644	carboxyltransferase (CT) interaction site; other site
1147129001645	biotinylation site [posttranslational modification]; other site
1147129001646	HlyD family secretion protein; Region: HlyD_3; pfam13437
1147129001647	tRNA pseudouridine synthase A; Reviewed; Region: PRK12434
1147129001648	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1147129001649	dimerization interface 3.5A [polypeptide binding]; other site
1147129001650	active site
1147129001651	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1147129001652	DNA-binding site [nucleotide binding]; DNA binding site
1147129001653	RNA-binding motif; other site
1147129001654	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1147129001655	Transposase; Region: HTH_Tnp_1; pfam01527
1147129001656	putative transposase OrfB; Reviewed; Region: PHA02517
1147129001657	HTH-like domain; Region: HTH_21; pfam13276
1147129001658	Integrase core domain; Region: rve; pfam00665
1147129001659	Integrase core domain; Region: rve_3; pfam13683
1147129001660	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1147129001661	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
1147129001662	active site
1147129001663	FMN binding site [chemical binding]; other site
1147129001664	substrate binding site [chemical binding]; other site
1147129001665	3Fe-4S cluster binding site [ion binding]; other site
1147129001666	tetrahydromethanopterin S-methyltransferase subunit H; Provisional; Region: PRK00979
1147129001667	Tetrahydromethanopterin S-methyltransferase, subunit H [Coenzyme metabolism]; Region: MtrH; cl15798
1147129001668	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
1147129001669	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
1147129001670	putative dimer interface [polypeptide binding]; other site
1147129001671	active site pocket [active]
1147129001672	putative cataytic base [active]
1147129001673	Accessory gene regulator B; Region: AgrB; pfam04647
1147129001674	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
1147129001675	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
1147129001676	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
1147129001677	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1147129001678	ligand binding site [chemical binding]; other site
1147129001679	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1147129001680	PAS domain; Region: PAS_9; pfam13426
1147129001681	putative active site [active]
1147129001682	heme pocket [chemical binding]; other site
1147129001683	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1147129001684	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1147129001685	metal binding site [ion binding]; metal-binding site
1147129001686	active site
1147129001687	I-site; other site
1147129001688	Uncharacterized conserved protein [Function unknown]; Region: COG1432
1147129001689	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
1147129001690	putative metal binding site [ion binding]; other site
1147129001691	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
1147129001692	DNA topoisomerase III; Provisional; Region: PRK07726
1147129001693	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1147129001694	active site
1147129001695	putative interdomain interaction site [polypeptide binding]; other site
1147129001696	putative metal-binding site [ion binding]; other site
1147129001697	putative nucleotide binding site [chemical binding]; other site
1147129001698	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1147129001699	domain I; other site
1147129001700	DNA binding groove [nucleotide binding]
1147129001701	phosphate binding site [ion binding]; other site
1147129001702	domain II; other site
1147129001703	domain III; other site
1147129001704	nucleotide binding site [chemical binding]; other site
1147129001705	catalytic site [active]
1147129001706	domain IV; other site
1147129001707	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1147129001708	DNA topoisomerase III; Provisional; Region: PRK07726
1147129001709	active site
1147129001710	putative interdomain interaction site [polypeptide binding]; other site
1147129001711	putative metal-binding site [ion binding]; other site
1147129001712	putative nucleotide binding site [chemical binding]; other site
1147129001713	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1147129001714	domain I; other site
1147129001715	DNA binding groove [nucleotide binding]
1147129001716	phosphate binding site [ion binding]; other site
1147129001717	domain II; other site
1147129001718	domain III; other site
1147129001719	nucleotide binding site [chemical binding]; other site
1147129001720	catalytic site [active]
1147129001721	domain IV; other site
1147129001722	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
1147129001723	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
1147129001724	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
1147129001725	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1147129001726	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129001727	active site
1147129001728	phosphorylation site [posttranslational modification]
1147129001729	intermolecular recognition site; other site
1147129001730	dimerization interface [polypeptide binding]; other site
1147129001731	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
1147129001732	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1147129001733	ATP binding site [chemical binding]; other site
1147129001734	Mg++ binding site [ion binding]; other site
1147129001735	motif III; other site
1147129001736	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1147129001737	nucleotide binding region [chemical binding]; other site
1147129001738	ATP-binding site [chemical binding]; other site
1147129001739	RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500
1147129001740	RNA binding site [nucleotide binding]; other site
1147129001741	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
1147129001742	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
1147129001743	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1147129001744	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
1147129001745	active site
1147129001746	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
1147129001747	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1147129001748	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1147129001749	acyl-activating enzyme (AAE) consensus motif; other site
1147129001750	AMP binding site [chemical binding]; other site
1147129001751	active site
1147129001752	CoA binding site [chemical binding]; other site
1147129001753	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1147129001754	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
1147129001755	acyl-activating enzyme (AAE) consensus motif; other site
1147129001756	AMP binding site [chemical binding]; other site
1147129001757	active site
1147129001758	CoA binding site [chemical binding]; other site
1147129001759	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
1147129001760	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
1147129001761	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1147129001762	dimer interface [polypeptide binding]; other site
1147129001763	PYR/PP interface [polypeptide binding]; other site
1147129001764	TPP binding site [chemical binding]; other site
1147129001765	substrate binding site [chemical binding]; other site
1147129001766	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
1147129001767	TPP-binding site; other site
1147129001768	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1147129001769	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
1147129001770	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1147129001771	Walker A/P-loop; other site
1147129001772	ATP binding site [chemical binding]; other site
1147129001773	Q-loop/lid; other site
1147129001774	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1147129001775	ABC transporter signature motif; other site
1147129001776	Walker B; other site
1147129001777	D-loop; other site
1147129001778	H-loop/switch region; other site
1147129001779	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
1147129001780	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1147129001781	active site
1147129001782	metal binding site [ion binding]; metal-binding site
1147129001783	DNA binding site [nucleotide binding]
1147129001784	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
1147129001785	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107
1147129001786	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1147129001787	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602
1147129001788	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1147129001789	active site
1147129001790	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1147129001791	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1147129001792	dimer interface [polypeptide binding]; other site
1147129001793	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147129001794	catalytic residue [active]
1147129001795	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1147129001796	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1147129001797	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1147129001798	Walker A/P-loop; other site
1147129001799	ATP binding site [chemical binding]; other site
1147129001800	Q-loop/lid; other site
1147129001801	ABC transporter signature motif; other site
1147129001802	Walker B; other site
1147129001803	D-loop; other site
1147129001804	H-loop/switch region; other site
1147129001805	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129001806	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129001807	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129001808	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1147129001809	PEGA domain; Region: PEGA; pfam08308
1147129001810	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cd10585
1147129001811	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116
1147129001812	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1147129001813	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1147129001814	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129001815	active site
1147129001816	phosphorylation site [posttranslational modification]
1147129001817	intermolecular recognition site; other site
1147129001818	dimerization interface [polypeptide binding]; other site
1147129001819	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1147129001820	DNA binding residues [nucleotide binding]
1147129001821	dimerization interface [polypeptide binding]; other site
1147129001822	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1147129001823	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147129001824	ATP binding site [chemical binding]; other site
1147129001825	Mg2+ binding site [ion binding]; other site
1147129001826	G-X-G motif; other site
1147129001827	Trans-Isoprenyl Diphosphate Synthases; Region: Trans_IPPS; cd00867
1147129001828	substrate binding pocket [chemical binding]; other site
1147129001829	substrate-Mg2+ binding site; other site
1147129001830	aspartate-rich region 1; other site
1147129001831	aspartate-rich region 2; other site
1147129001832	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1147129001833	hypothetical protein; Provisional; Region: PRK02877
1147129001834	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1147129001835	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1147129001836	metal binding site [ion binding]; metal-binding site
1147129001837	active site
1147129001838	I-site; other site
1147129001839	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
1147129001840	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1147129001841	Zn2+ binding site [ion binding]; other site
1147129001842	Mg2+ binding site [ion binding]; other site
1147129001843	oligosaccharyl transferase, archaeosortase A system-associated; Region: archaeo_STT3; TIGR04154
1147129001844	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
1147129001845	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
1147129001846	putative active site; other site
1147129001847	catalytic triad [active]
1147129001848	putative dimer interface [polypeptide binding]; other site
1147129001849	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
1147129001850	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
1147129001851	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1147129001852	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1147129001853	acyl-activating enzyme (AAE) consensus motif; other site
1147129001854	AMP binding site [chemical binding]; other site
1147129001855	active site
1147129001856	CoA binding site [chemical binding]; other site
1147129001857	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1147129001858	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147129001859	non-specific DNA binding site [nucleotide binding]; other site
1147129001860	salt bridge; other site
1147129001861	sequence-specific DNA binding site [nucleotide binding]; other site
1147129001862	Cupin domain; Region: Cupin_2; pfam07883
1147129001863	PilZ domain; Region: PilZ; pfam07238
1147129001864	Predicted permeases [General function prediction only]; Region: COG0679
1147129001865	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
1147129001866	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1147129001867	minor groove reading motif; other site
1147129001868	helix-hairpin-helix signature motif; other site
1147129001869	substrate binding pocket [chemical binding]; other site
1147129001870	active site
1147129001871	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1147129001872	DNA binding and oxoG recognition site [nucleotide binding]
1147129001873	ribonuclease Y; Region: RNase_Y; TIGR03319
1147129001874	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1147129001875	active site
1147129001876	metal binding site [ion binding]; metal-binding site
1147129001877	DNA binding site [nucleotide binding]
1147129001878	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1147129001879	Influenza RNA-dependent RNA polymerase subunit PA; Region: Flu_PA; pfam00603
1147129001880	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1147129001881	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
1147129001882	active site
1147129001883	metal binding site [ion binding]; metal-binding site
1147129001884	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1147129001885	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1147129001886	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1147129001887	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1147129001888	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1147129001889	NlpC/P60 family; Region: NLPC_P60; pfam00877
1147129001890	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1147129001891	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1147129001892	substrate binding pocket [chemical binding]; other site
1147129001893	membrane-bound complex binding site; other site
1147129001894	hinge residues; other site
1147129001895	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1147129001896	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1147129001897	dimer interface [polypeptide binding]; other site
1147129001898	phosphorylation site [posttranslational modification]
1147129001899	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147129001900	ATP binding site [chemical binding]; other site
1147129001901	Mg2+ binding site [ion binding]; other site
1147129001902	G-X-G motif; other site
1147129001903	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1147129001904	Response regulator receiver domain; Region: Response_reg; pfam00072
1147129001905	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129001906	active site
1147129001907	phosphorylation site [posttranslational modification]
1147129001908	intermolecular recognition site; other site
1147129001909	dimerization interface [polypeptide binding]; other site
1147129001910	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
1147129001911	putative binding surface; other site
1147129001912	active site
1147129001913	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
1147129001914	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129001915	active site
1147129001916	phosphorylation site [posttranslational modification]
1147129001917	intermolecular recognition site; other site
1147129001918	dimerization interface [polypeptide binding]; other site
1147129001919	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1147129001920	Zn2+ binding site [ion binding]; other site
1147129001921	Mg2+ binding site [ion binding]; other site
1147129001922	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1147129001923	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1147129001924	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
1147129001925	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1147129001926	RNA binding surface [nucleotide binding]; other site
1147129001927	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
1147129001928	active site
1147129001929	Zn binding site [ion binding]; other site
1147129001930	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
1147129001931	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
1147129001932	Peptidase family M23; Region: Peptidase_M23; pfam01551
1147129001933	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1147129001934	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1147129001935	putative active site [active]
1147129001936	putative NTP binding site [chemical binding]; other site
1147129001937	putative nucleic acid binding site [nucleotide binding]; other site
1147129001938	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
1147129001939	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1147129001940	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1147129001941	DNA binding residues [nucleotide binding]
1147129001942	dimerization interface [polypeptide binding]; other site
1147129001943	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
1147129001944	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1147129001945	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1147129001946	Walker A/P-loop; other site
1147129001947	ATP binding site [chemical binding]; other site
1147129001948	Q-loop/lid; other site
1147129001949	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1147129001950	ABC transporter signature motif; other site
1147129001951	Walker B; other site
1147129001952	D-loop; other site
1147129001953	ABC transporter; Region: ABC_tran_2; pfam12848
1147129001954	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1147129001955	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1147129001956	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1147129001957	ABC transporter; Region: ABC_tran_2; pfam12848
1147129001958	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1147129001959	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1147129001960	Predicted transcriptional regulators [Transcription]; Region: COG1695
1147129001961	Transcriptional regulator PadR-like family; Region: PadR; cl17335
1147129001962	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1147129001963	EamA-like transporter family; Region: EamA; pfam00892
1147129001964	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1147129001965	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
1147129001966	putative active site [active]
1147129001967	catalytic triad [active]
1147129001968	dimer interface [polypeptide binding]; other site
1147129001969	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1147129001970	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1147129001971	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
1147129001972	NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852
1147129001973	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
1147129001974	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
1147129001975	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
1147129001976	hydrogenase 4 subunit F; Validated; Region: PRK06458
1147129001977	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1147129001978	Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899
1147129001979	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
1147129001980	NADH dehydrogenase; Region: NADHdh; cl00469
1147129001981	hydrogenase 4 subunit B; Validated; Region: PRK06521
1147129001982	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1147129001983	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1147129001984	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1147129001985	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1147129001986	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1147129001987	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1147129001988	Spore germination protein; Region: Spore_permease; cl17796
1147129001989	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1147129001990	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1147129001991	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1147129001992	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1147129001993	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147129001994	homodimer interface [polypeptide binding]; other site
1147129001995	catalytic residue [active]
1147129001996	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1147129001997	ligand binding site [chemical binding]; other site
1147129001998	active site
1147129001999	UGI interface [polypeptide binding]; other site
1147129002000	catalytic site [active]
1147129002001	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
1147129002002	S1 domain; Region: S1_2; pfam13509
1147129002003	S1 domain; Region: S1_2; pfam13509
1147129002004	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1147129002005	RNA binding site [nucleotide binding]; other site
1147129002006	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
1147129002007	active site clefts [active]
1147129002008	zinc binding site [ion binding]; other site
1147129002009	dimer interface [polypeptide binding]; other site
1147129002010	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1147129002011	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1147129002012	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
1147129002013	active site
1147129002014	tryptophan synthase subunit beta; Reviewed; Region: PRK12391
1147129002015	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1147129002016	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1147129002017	catalytic residue [active]
1147129002018	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
1147129002019	G5 domain; Region: G5; pfam07501
1147129002020	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1147129002021	NlpC/P60 family; Region: NLPC_P60; pfam00877
1147129002022	Protein of unknown function (DUF456); Region: DUF456; pfam04306
1147129002023	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1147129002024	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1147129002025	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1147129002026	Walker A/P-loop; other site
1147129002027	ATP binding site [chemical binding]; other site
1147129002028	Q-loop/lid; other site
1147129002029	ABC transporter signature motif; other site
1147129002030	Walker B; other site
1147129002031	D-loop; other site
1147129002032	H-loop/switch region; other site
1147129002033	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1147129002034	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1147129002035	DNA binding residues [nucleotide binding]
1147129002036	dimer interface [polypeptide binding]; other site
1147129002037	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1147129002038	Helix-turn-helix domain; Region: HTH_38; pfam13936
1147129002039	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1147129002040	Rubrerythrin [Energy production and conversion]; Region: COG1592
1147129002041	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
1147129002042	binuclear metal center [ion binding]; other site
1147129002043	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
1147129002044	iron binding site [ion binding]; other site
1147129002045	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147129002046	putative substrate translocation pore; other site
1147129002047	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1147129002048	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1147129002049	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1147129002050	classical (c) SDRs; Region: SDR_c; cd05233
1147129002051	NAD(P) binding site [chemical binding]; other site
1147129002052	active site
1147129002053	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1147129002054	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1147129002055	dimerization interface [polypeptide binding]; other site
1147129002056	domain crossover interface; other site
1147129002057	redox-dependent activation switch; other site
1147129002058	Predicted membrane protein [Function unknown]; Region: COG1511
1147129002059	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
1147129002060	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1147129002061	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1147129002062	Domain of unknown function (DUF4405); Region: DUF4405; pfam14358
1147129002063	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572
1147129002064	cobyric acid synthase; Provisional; Region: PRK00784
1147129002065	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1147129002066	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1147129002067	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1147129002068	catalytic triad [active]
1147129002069	cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200
1147129002070	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294
1147129002071	threonine-phosphate decarboxylase; Provisional; Region: PRK06358
1147129002072	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1147129002073	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147129002074	homodimer interface [polypeptide binding]; other site
1147129002075	catalytic residue [active]
1147129002076	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
1147129002077	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1147129002078	catalytic core [active]
1147129002079	Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363
1147129002080	cobalamin synthase; Reviewed; Region: cobS; PRK00235
1147129002081	Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363
1147129002082	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
1147129002083	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1147129002084	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
1147129002085	catalytic triad [active]
1147129002086	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1147129002087	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1147129002088	Walker A/P-loop; other site
1147129002089	ATP binding site [chemical binding]; other site
1147129002090	Q-loop/lid; other site
1147129002091	ABC transporter signature motif; other site
1147129002092	Walker B; other site
1147129002093	D-loop; other site
1147129002094	H-loop/switch region; other site
1147129002095	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1147129002096	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147129002097	S-adenosylmethionine binding site [chemical binding]; other site
1147129002098	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1147129002099	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1147129002100	Walker A/P-loop; other site
1147129002101	ATP binding site [chemical binding]; other site
1147129002102	Q-loop/lid; other site
1147129002103	ABC transporter signature motif; other site
1147129002104	Walker B; other site
1147129002105	D-loop; other site
1147129002106	H-loop/switch region; other site
1147129002107	ABC transporter; Region: ABC_tran_2; pfam12848
1147129002108	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1147129002109	Ion transport protein; Region: Ion_trans; pfam00520
1147129002110	Ion channel; Region: Ion_trans_2; pfam07885
1147129002111	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1147129002112	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129002113	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129002114	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129002115	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1147129002116	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
1147129002117	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1147129002118	Cysteine-rich domain; Region: CCG; pfam02754
1147129002119	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1147129002120	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
1147129002121	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
1147129002122	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
1147129002123	Putative glucoamylase; Region: Glycoamylase; pfam10091
1147129002124	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
1147129002125	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
1147129002126	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
1147129002127	Protein of unknown function, DUF608; Region: DUF608; pfam04685
1147129002128	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1147129002129	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1147129002130	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1147129002131	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
1147129002132	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1147129002133	active site
1147129002134	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1147129002135	Winged helix-turn helix; Region: HTH_29; pfam13551
1147129002136	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
1147129002137	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1147129002138	FMN binding site [chemical binding]; other site
1147129002139	dimer interface [polypeptide binding]; other site
1147129002140	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1147129002141	Sulfatase; Region: Sulfatase; pfam00884
1147129002142	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
1147129002143	dimerization interface [polypeptide binding]; other site
1147129002144	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
1147129002145	ATP binding site [chemical binding]; other site
1147129002146	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
1147129002147	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
1147129002148	HupF/HypC family; Region: HupF_HypC; pfam01455
1147129002149	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1147129002150	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
1147129002151	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
1147129002152	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1147129002153	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1147129002154	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
1147129002155	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
1147129002156	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
1147129002157	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
1147129002158	NADH dehydrogenase; Region: NADHdh; cl00469
1147129002159	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
1147129002160	NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NuoL; COG1009
1147129002161	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1147129002162	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1147129002163	aspartate aminotransferase; Provisional; Region: PRK05764
1147129002164	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1147129002165	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147129002166	homodimer interface [polypeptide binding]; other site
1147129002167	catalytic residue [active]
1147129002168	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1147129002169	FtsX-like permease family; Region: FtsX; pfam02687
1147129002170	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1147129002171	FtsX-like permease family; Region: FtsX; pfam02687
1147129002172	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1147129002173	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1147129002174	Walker A/P-loop; other site
1147129002175	ATP binding site [chemical binding]; other site
1147129002176	Q-loop/lid; other site
1147129002177	ABC transporter signature motif; other site
1147129002178	Walker B; other site
1147129002179	D-loop; other site
1147129002180	H-loop/switch region; other site
1147129002181	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1147129002182	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1147129002183	dimer interface [polypeptide binding]; other site
1147129002184	phosphorylation site [posttranslational modification]
1147129002185	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147129002186	ATP binding site [chemical binding]; other site
1147129002187	Mg2+ binding site [ion binding]; other site
1147129002188	G-X-G motif; other site
1147129002189	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1147129002190	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129002191	active site
1147129002192	phosphorylation site [posttranslational modification]
1147129002193	intermolecular recognition site; other site
1147129002194	dimerization interface [polypeptide binding]; other site
1147129002195	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1147129002196	DNA binding site [nucleotide binding]
1147129002197	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
1147129002198	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1147129002199	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
1147129002200	DNA binding residues [nucleotide binding]
1147129002201	dimer interface [polypeptide binding]; other site
1147129002202	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1147129002203	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1147129002204	NAD(P) binding site [chemical binding]; other site
1147129002205	active site
1147129002206	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1147129002207	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1147129002208	Walker A/P-loop; other site
1147129002209	ATP binding site [chemical binding]; other site
1147129002210	Q-loop/lid; other site
1147129002211	ABC transporter signature motif; other site
1147129002212	Walker B; other site
1147129002213	D-loop; other site
1147129002214	H-loop/switch region; other site
1147129002215	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1147129002216	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1147129002217	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1147129002218	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147129002219	non-specific DNA binding site [nucleotide binding]; other site
1147129002220	salt bridge; other site
1147129002221	sequence-specific DNA binding site [nucleotide binding]; other site
1147129002222	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
1147129002223	elongation factor G; Reviewed; Region: PRK12740
1147129002224	G1 box; other site
1147129002225	putative GEF interaction site [polypeptide binding]; other site
1147129002226	GTP/Mg2+ binding site [chemical binding]; other site
1147129002227	Switch I region; other site
1147129002228	G2 box; other site
1147129002229	G3 box; other site
1147129002230	Switch II region; other site
1147129002231	G4 box; other site
1147129002232	G5 box; other site
1147129002233	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1147129002234	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
1147129002235	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1147129002236	stage V sporulation protein B; Region: spore_V_B; TIGR02900
1147129002237	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1147129002238	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
1147129002239	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
1147129002240	homodecamer interface [polypeptide binding]; other site
1147129002241	GTP cyclohydrolase I; Provisional; Region: PLN03044
1147129002242	active site
1147129002243	putative catalytic site residues [active]
1147129002244	zinc binding site [ion binding]; other site
1147129002245	GTP-CH-I/GFRP interaction surface; other site
1147129002246	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1147129002247	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1147129002248	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
1147129002249	TrkA-C domain; Region: TrkA_C; pfam02080
1147129002250	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
1147129002251	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147129002252	S-adenosylmethionine binding site [chemical binding]; other site
1147129002253	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1147129002254	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147129002255	binding surface
1147129002256	TPR motif; other site
1147129002257	TPR repeat; Region: TPR_11; pfam13414
1147129002258	TPR repeat; Region: TPR_11; pfam13414
1147129002259	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147129002260	TPR motif; other site
1147129002261	binding surface
1147129002262	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1147129002263	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147129002264	TPR motif; other site
1147129002265	TPR repeat; Region: TPR_11; pfam13414
1147129002266	binding surface
1147129002267	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1147129002268	PLD-like domain; Region: PLDc_2; pfam13091
1147129002269	putative active site [active]
1147129002270	catalytic site [active]
1147129002271	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1147129002272	PLD-like domain; Region: PLDc_2; pfam13091
1147129002273	putative active site [active]
1147129002274	catalytic site [active]
1147129002275	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1147129002276	Sulfatase; Region: Sulfatase; pfam00884
1147129002277	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1147129002278	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1147129002279	oligomerization interface [polypeptide binding]; other site
1147129002280	active site
1147129002281	metal binding site [ion binding]; metal-binding site
1147129002282	Protein of unknown function (DUF3792); Region: DUF3792; pfam12670
1147129002283	cell division protein FtsA; Region: ftsA; TIGR01174
1147129002284	Cell division protein FtsA; Region: FtsA; smart00842
1147129002285	Cell division protein FtsA; Region: FtsA; pfam14450
1147129002286	6-phosphofructokinase; Provisional; Region: PRK03202
1147129002287	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1147129002288	active site
1147129002289	ADP/pyrophosphate binding site [chemical binding]; other site
1147129002290	dimerization interface [polypeptide binding]; other site
1147129002291	allosteric effector site; other site
1147129002292	fructose-1,6-bisphosphate binding site; other site
1147129002293	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1147129002294	Walker A motif; other site
1147129002295	ATP binding site [chemical binding]; other site
1147129002296	Walker B motif; other site
1147129002297	arginine finger; other site
1147129002298	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1147129002299	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1147129002300	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1147129002301	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1147129002302	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1147129002303	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147129002304	TPR motif; other site
1147129002305	binding surface
1147129002306	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1147129002307	polysaccharide deacetylase family sporulation protein PdaB; Region: spore_ybaN_pdaB; TIGR02764
1147129002308	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1147129002309	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1147129002310	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1147129002311	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1147129002312	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1147129002313	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1147129002314	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
1147129002315	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1147129002316	TMP-binding site; other site
1147129002317	ATP-binding site [chemical binding]; other site
1147129002318	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
1147129002319	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129002320	active site
1147129002321	phosphorylation site [posttranslational modification]
1147129002322	intermolecular recognition site; other site
1147129002323	dimerization interface [polypeptide binding]; other site
1147129002324	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
1147129002325	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
1147129002326	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1147129002327	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1147129002328	ATP binding site [chemical binding]; other site
1147129002329	DEAD_2; Region: DEAD_2; pfam06733
1147129002330	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1147129002331	DNA gyrase subunit A; Validated; Region: PRK05560
1147129002332	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
1147129002333	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1147129002334	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1147129002335	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1147129002336	catalytic residues [active]
1147129002337	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
1147129002338	putative homodimer interface [polypeptide binding]; other site
1147129002339	putative homotetramer interface [polypeptide binding]; other site
1147129002340	putative allosteric switch controlling residues; other site
1147129002341	putative metal binding site [ion binding]; other site
1147129002342	putative homodimer-homodimer interface [polypeptide binding]; other site
1147129002343	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1147129002344	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1147129002345	dimer interface [polypeptide binding]; other site
1147129002346	anticodon binding site; other site
1147129002347	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1147129002348	homodimer interface [polypeptide binding]; other site
1147129002349	motif 1; other site
1147129002350	active site
1147129002351	motif 2; other site
1147129002352	GAD domain; Region: GAD; pfam02938
1147129002353	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1147129002354	motif 3; other site
1147129002355	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1147129002356	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1147129002357	dimer interface [polypeptide binding]; other site
1147129002358	motif 1; other site
1147129002359	active site
1147129002360	motif 2; other site
1147129002361	motif 3; other site
1147129002362	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1147129002363	anticodon binding site; other site
1147129002364	coproporphyrinogen III oxidase; Provisional; Region: PRK08207
1147129002365	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147129002366	FeS/SAM binding site; other site
1147129002367	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1147129002368	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1147129002369	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1147129002370	Zn2+ binding site [ion binding]; other site
1147129002371	Mg2+ binding site [ion binding]; other site
1147129002372	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1147129002373	synthetase active site [active]
1147129002374	NTP binding site [chemical binding]; other site
1147129002375	metal binding site [ion binding]; metal-binding site
1147129002376	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1147129002377	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1147129002378	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
1147129002379	DHH family; Region: DHH; pfam01368
1147129002380	DHHA1 domain; Region: DHHA1; pfam02272
1147129002381	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
1147129002382	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
1147129002383	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1147129002384	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1147129002385	putative valine binding site [chemical binding]; other site
1147129002386	dimer interface [polypeptide binding]; other site
1147129002387	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1147129002388	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
1147129002389	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1147129002390	PYR/PP interface [polypeptide binding]; other site
1147129002391	dimer interface [polypeptide binding]; other site
1147129002392	TPP binding site [chemical binding]; other site
1147129002393	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1147129002394	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1147129002395	TPP-binding site [chemical binding]; other site
1147129002396	dimer interface [polypeptide binding]; other site
1147129002397	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
1147129002398	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1147129002399	Protein export membrane protein; Region: SecD_SecF; pfam02355
1147129002400	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
1147129002401	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1147129002402	Preprotein translocase subunit; Region: YajC; cl00806
1147129002403	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1147129002404	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1147129002405	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1147129002406	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1147129002407	Stage II sporulation protein; Region: SpoIID; pfam08486
1147129002408	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
1147129002409	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1147129002410	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147129002411	Walker A motif; other site
1147129002412	ATP binding site [chemical binding]; other site
1147129002413	Walker B motif; other site
1147129002414	arginine finger; other site
1147129002415	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1147129002416	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1147129002417	RuvA N terminal domain; Region: RuvA_N; pfam01330
1147129002418	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1147129002419	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
1147129002420	active site
1147129002421	putative DNA-binding cleft [nucleotide binding]; other site
1147129002422	dimer interface [polypeptide binding]; other site
1147129002423	hypothetical protein; Validated; Region: PRK00110
1147129002424	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1147129002425	dimer interface [polypeptide binding]; other site
1147129002426	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
1147129002427	putative CheW interface [polypeptide binding]; other site
1147129002428	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1147129002429	Spore germination protein; Region: Spore_permease; cl17796
1147129002430	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1147129002431	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1147129002432	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
1147129002433	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
1147129002434	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
1147129002435	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
1147129002436	4Fe-4S binding domain; Region: Fer4; pfam00037
1147129002437	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
1147129002438	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1147129002439	molybdopterin cofactor binding site; other site
1147129002440	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1147129002441	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1147129002442	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
1147129002443	molybdopterin cofactor binding site; other site
1147129002444	Acylphosphatase; Region: Acylphosphatase; pfam00708
1147129002445	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
1147129002446	HypF finger; Region: zf-HYPF; pfam07503
1147129002447	HypF finger; Region: zf-HYPF; pfam07503
1147129002448	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
1147129002449	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1147129002450	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1147129002451	substrate binding pocket [chemical binding]; other site
1147129002452	membrane-bound complex binding site; other site
1147129002453	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1147129002454	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1147129002455	Walker A/P-loop; other site
1147129002456	ATP binding site [chemical binding]; other site
1147129002457	Q-loop/lid; other site
1147129002458	ABC transporter signature motif; other site
1147129002459	Walker B; other site
1147129002460	D-loop; other site
1147129002461	H-loop/switch region; other site
1147129002462	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1147129002463	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147129002464	dimer interface [polypeptide binding]; other site
1147129002465	conserved gate region; other site
1147129002466	putative PBP binding loops; other site
1147129002467	ABC-ATPase subunit interface; other site
1147129002468	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1147129002469	catalytic loop [active]
1147129002470	iron binding site [ion binding]; other site
1147129002471	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1147129002472	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
1147129002473	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
1147129002474	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
1147129002475	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
1147129002476	dimer interface [polypeptide binding]; other site
1147129002477	[2Fe-2S] cluster binding site [ion binding]; other site
1147129002478	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
1147129002479	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
1147129002480	NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493
1147129002481	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1147129002482	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1147129002483	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
1147129002484	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
1147129002485	putative dimer interface [polypeptide binding]; other site
1147129002486	[2Fe-2S] cluster binding site [ion binding]; other site
1147129002487	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1147129002488	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1147129002489	putative catalytic cysteine [active]
1147129002490	gamma-glutamyl kinase; Provisional; Region: PRK05429
1147129002491	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1147129002492	nucleotide binding site [chemical binding]; other site
1147129002493	homotetrameric interface [polypeptide binding]; other site
1147129002494	putative phosphate binding site [ion binding]; other site
1147129002495	putative allosteric binding site; other site
1147129002496	PUA domain; Region: PUA; pfam01472
1147129002497	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1147129002498	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1147129002499	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1147129002500	Protein of unknown function (DUF3102); Region: DUF3102; pfam11300
1147129002501	Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120
1147129002502	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1147129002503	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1147129002504	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1147129002505	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1147129002506	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1147129002507	putative active site [active]
1147129002508	putative NTP binding site [chemical binding]; other site
1147129002509	putative nucleic acid binding site [nucleotide binding]; other site
1147129002510	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
1147129002511	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1147129002512	active site
1147129002513	metal binding site [ion binding]; metal-binding site
1147129002514	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1147129002515	KTSC domain; Region: KTSC; pfam13619
1147129002516	HerA helicase [Replication, recombination, and repair]; Region: COG0433
1147129002517	Domain of unknown function DUF87; Region: DUF87; pfam01935
1147129002518	SIR2-like domain; Region: SIR2_2; pfam13289
1147129002519	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1147129002520	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1147129002521	putative active site [active]
1147129002522	putative NTP binding site [chemical binding]; other site
1147129002523	putative nucleic acid binding site [nucleotide binding]; other site
1147129002524	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
1147129002525	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
1147129002526	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1147129002527	MarR family; Region: MarR_2; pfam12802
1147129002528	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1147129002529	tartrate dehydrogenase; Region: TTC; TIGR02089
1147129002530	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
1147129002531	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1147129002532	substrate binding site [chemical binding]; other site
1147129002533	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1147129002534	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1147129002535	substrate binding site [chemical binding]; other site
1147129002536	ligand binding site [chemical binding]; other site
1147129002537	2-isopropylmalate synthase; Validated; Region: PRK00915
1147129002538	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1147129002539	active site
1147129002540	catalytic residues [active]
1147129002541	metal binding site [ion binding]; metal-binding site
1147129002542	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1147129002543	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1147129002544	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1147129002545	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1147129002546	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1147129002547	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1147129002548	putative valine binding site [chemical binding]; other site
1147129002549	dimer interface [polypeptide binding]; other site
1147129002550	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1147129002551	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
1147129002552	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1147129002553	PYR/PP interface [polypeptide binding]; other site
1147129002554	dimer interface [polypeptide binding]; other site
1147129002555	TPP binding site [chemical binding]; other site
1147129002556	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1147129002557	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1147129002558	TPP-binding site [chemical binding]; other site
1147129002559	dimer interface [polypeptide binding]; other site
1147129002560	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
1147129002561	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1147129002562	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
1147129002563	homodimer interface [polypeptide binding]; other site
1147129002564	substrate-cofactor binding pocket; other site
1147129002565	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147129002566	catalytic residue [active]
1147129002567	homoserine dehydrogenase; Provisional; Region: PRK06349
1147129002568	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1147129002569	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1147129002570	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1147129002571	homoserine kinase; Provisional; Region: PRK01212
1147129002572	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1147129002573	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1147129002574	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1147129002575	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1147129002576	catalytic residue [active]
1147129002577	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1147129002578	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1147129002579	CoA-binding site [chemical binding]; other site
1147129002580	ATP-binding [chemical binding]; other site
1147129002581	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
1147129002582	Domain of unknown function DUF; Region: DUF204; pfam02659
1147129002583	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1147129002584	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1147129002585	Walker A/P-loop; other site
1147129002586	ATP binding site [chemical binding]; other site
1147129002587	Q-loop/lid; other site
1147129002588	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1147129002589	ABC transporter signature motif; other site
1147129002590	Walker B; other site
1147129002591	ABC transporter; Region: ABC_tran_2; pfam12848
1147129002592	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1147129002593	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1147129002594	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1147129002595	DNA binding site [nucleotide binding]
1147129002596	catalytic residue [active]
1147129002597	H2TH interface [polypeptide binding]; other site
1147129002598	putative catalytic residues [active]
1147129002599	turnover-facilitating residue; other site
1147129002600	intercalation triad [nucleotide binding]; other site
1147129002601	8OG recognition residue [nucleotide binding]; other site
1147129002602	putative reading head residues; other site
1147129002603	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1147129002604	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1147129002605	DNA polymerase I; Region: pola; TIGR00593
1147129002606	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1147129002607	active site
1147129002608	metal binding site 1 [ion binding]; metal-binding site
1147129002609	putative 5' ssDNA interaction site; other site
1147129002610	metal binding site 3; metal-binding site
1147129002611	metal binding site 2 [ion binding]; metal-binding site
1147129002612	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1147129002613	putative DNA binding site [nucleotide binding]; other site
1147129002614	putative metal binding site [ion binding]; other site
1147129002615	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
1147129002616	active site
1147129002617	catalytic site [active]
1147129002618	substrate binding site [chemical binding]; other site
1147129002619	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1147129002620	active site
1147129002621	DNA binding site [nucleotide binding]
1147129002622	catalytic site [active]
1147129002623	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
1147129002624	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1147129002625	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1147129002626	acyl-activating enzyme (AAE) consensus motif; other site
1147129002627	AMP binding site [chemical binding]; other site
1147129002628	active site
1147129002629	CoA binding site [chemical binding]; other site
1147129002630	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1147129002631	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147129002632	non-specific DNA binding site [nucleotide binding]; other site
1147129002633	salt bridge; other site
1147129002634	sequence-specific DNA binding site [nucleotide binding]; other site
1147129002635	Cupin domain; Region: Cupin_2; pfam07883
1147129002636	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
1147129002637	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
1147129002638	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013
1147129002639	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
1147129002640	TPP-binding site [chemical binding]; other site
1147129002641	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
1147129002642	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1147129002643	dimer interface [polypeptide binding]; other site
1147129002644	PYR/PP interface [polypeptide binding]; other site
1147129002645	TPP binding site [chemical binding]; other site
1147129002646	substrate binding site [chemical binding]; other site
1147129002647	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1147129002648	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
1147129002649	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
1147129002650	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1147129002651	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1147129002652	active site
1147129002653	(T/H)XGH motif; other site
1147129002654	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826
1147129002655	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
1147129002656	active site
1147129002657	PHP Thumb interface [polypeptide binding]; other site
1147129002658	metal binding site [ion binding]; metal-binding site
1147129002659	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1147129002660	generic binding surface II; other site
1147129002661	generic binding surface I; other site
1147129002662	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
1147129002663	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147129002664	DNA-binding site [nucleotide binding]; DNA binding site
1147129002665	DRTGG domain; Region: DRTGG; pfam07085
1147129002666	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
1147129002667	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1147129002668	active site 2 [active]
1147129002669	active site 1 [active]
1147129002670	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1147129002671	metal-dependent hydrolase; Provisional; Region: PRK00685
1147129002672	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1147129002673	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1147129002674	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1147129002675	Mg++ binding site [ion binding]; other site
1147129002676	putative catalytic motif [active]
1147129002677	substrate binding site [chemical binding]; other site
1147129002678	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1147129002679	aconitate hydratase; Validated; Region: PRK07229
1147129002680	Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585
1147129002681	substrate binding site [chemical binding]; other site
1147129002682	ligand binding site [chemical binding]; other site
1147129002683	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
1147129002684	substrate binding site [chemical binding]; other site
1147129002685	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1147129002686	HD domain; Region: HD_4; pfam13328
1147129002687	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
1147129002688	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
1147129002689	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
1147129002690	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147129002691	non-specific DNA binding site [nucleotide binding]; other site
1147129002692	salt bridge; other site
1147129002693	sequence-specific DNA binding site [nucleotide binding]; other site
1147129002694	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1147129002695	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1147129002696	AsnC family; Region: AsnC_trans_reg; pfam01037
1147129002697	hypothetical protein; Validated; Region: PRK07682
1147129002698	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1147129002699	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147129002700	homodimer interface [polypeptide binding]; other site
1147129002701	catalytic residue [active]
1147129002702	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
1147129002703	Rubredoxin [Energy production and conversion]; Region: COG1773
1147129002704	iron binding site [ion binding]; other site
1147129002705	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
1147129002706	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
1147129002707	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1147129002708	active site
1147129002709	NTP binding site [chemical binding]; other site
1147129002710	metal binding triad [ion binding]; metal-binding site
1147129002711	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1147129002712	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
1147129002713	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389
1147129002714	NAD binding site [chemical binding]; other site
1147129002715	ligand binding site [chemical binding]; other site
1147129002716	catalytic site [active]
1147129002717	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
1147129002718	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
1147129002719	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1147129002720	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1147129002721	active site
1147129002722	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
1147129002723	MoxR-like ATPases [General function prediction only]; Region: COG0714
1147129002724	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1147129002725	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
1147129002726	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
1147129002727	RmuC family; Region: RmuC; pfam02646
1147129002728	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1147129002729	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1147129002730	Catalytic site [active]
1147129002731	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1147129002732	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
1147129002733	putative ligand binding site [chemical binding]; other site
1147129002734	putative NAD binding site [chemical binding]; other site
1147129002735	catalytic site [active]
1147129002736	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1147129002737	calcium/proton exchanger (cax); Region: cax; TIGR00378
1147129002738	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1147129002739	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1147129002740	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1147129002741	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1147129002742	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
1147129002743	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1147129002744	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147129002745	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1147129002746	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1147129002747	Uncharacterized BCR, COG1636; Region: DUF208; pfam02677
1147129002748	FOG: CBS domain [General function prediction only]; Region: COG0517
1147129002749	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
1147129002750	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
1147129002751	Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972
1147129002752	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
1147129002753	active site
1147129002754	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1147129002755	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1147129002756	substrate binding pocket [chemical binding]; other site
1147129002757	chain length determination region; other site
1147129002758	substrate-Mg2+ binding site; other site
1147129002759	catalytic residues [active]
1147129002760	aspartate-rich region 1; other site
1147129002761	active site lid residues [active]
1147129002762	aspartate-rich region 2; other site
1147129002763	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
1147129002764	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
1147129002765	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
1147129002766	substrate binding pocket [chemical binding]; other site
1147129002767	aspartate-rich region 1; other site
1147129002768	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1147129002769	Cysteine-rich domain; Region: CCG; pfam02754
1147129002770	Cysteine-rich domain; Region: CCG; pfam02754
1147129002771	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1147129002772	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
1147129002773	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1147129002774	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1147129002775	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1147129002776	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1147129002777	Ligand binding site [chemical binding]; other site
1147129002778	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1147129002779	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
1147129002780	putative active site [active]
1147129002781	putative metal binding site [ion binding]; other site
1147129002782	Cache domain; Region: Cache_1; pfam02743
1147129002783	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1147129002784	dimerization interface [polypeptide binding]; other site
1147129002785	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1147129002786	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1147129002787	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1147129002788	dimer interface [polypeptide binding]; other site
1147129002789	putative CheW interface [polypeptide binding]; other site
1147129002790	hypothetical protein; Provisional; Region: PRK04435
1147129002791	C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888
1147129002792	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1147129002793	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1147129002794	putative active site [active]
1147129002795	putative NTP binding site [chemical binding]; other site
1147129002796	putative nucleic acid binding site [nucleotide binding]; other site
1147129002797	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
1147129002798	Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547
1147129002799	stage IV sporulation protein A; Region: spore_IV_A; TIGR02836
1147129002800	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1147129002801	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1147129002802	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1147129002803	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
1147129002804	GTP-binding protein Der; Reviewed; Region: PRK00093
1147129002805	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1147129002806	G1 box; other site
1147129002807	GTP/Mg2+ binding site [chemical binding]; other site
1147129002808	Switch I region; other site
1147129002809	G2 box; other site
1147129002810	Switch II region; other site
1147129002811	G3 box; other site
1147129002812	G4 box; other site
1147129002813	G5 box; other site
1147129002814	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1147129002815	G1 box; other site
1147129002816	GTP/Mg2+ binding site [chemical binding]; other site
1147129002817	Switch I region; other site
1147129002818	G2 box; other site
1147129002819	G3 box; other site
1147129002820	Switch II region; other site
1147129002821	G4 box; other site
1147129002822	G5 box; other site
1147129002823	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136
1147129002824	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
1147129002825	Protein of unknown function (DUF512); Region: DUF512; pfam04459
1147129002826	cell division protein FtsW; Region: ftsW; TIGR02614
1147129002827	4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087
1147129002828	LytB protein; Region: LYTB; cl00507
1147129002829	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1147129002830	RNA binding site [nucleotide binding]; other site
1147129002831	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1147129002832	RNA binding site [nucleotide binding]; other site
1147129002833	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1147129002834	RNA binding site [nucleotide binding]; other site
1147129002835	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1147129002836	RNA binding site [nucleotide binding]; other site
1147129002837	domain interface; other site
1147129002838	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1147129002839	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1147129002840	putative acyl-acceptor binding pocket; other site
1147129002841	cytidylate kinase; Provisional; Region: cmk; PRK00023
1147129002842	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1147129002843	CMP-binding site; other site
1147129002844	The sites determining sugar specificity; other site
1147129002845	CAAX protease self-immunity; Region: Abi; pfam02517
1147129002846	Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640
1147129002847	hexamer interface [polypeptide binding]; other site
1147129002848	RNA binding site [nucleotide binding]; other site
1147129002849	Histidine-zinc binding site [chemical binding]; other site
1147129002850	flavoprotein, HI0933 family; Region: TIGR00275
1147129002851	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1147129002852	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1147129002853	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1147129002854	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1147129002855	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147129002856	DNA-binding site [nucleotide binding]; DNA binding site
1147129002857	FCD domain; Region: FCD; pfam07729
1147129002858	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1147129002859	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1147129002860	RNA binding surface [nucleotide binding]; other site
1147129002861	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1147129002862	active site
1147129002863	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
1147129002864	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
1147129002865	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
1147129002866	Protein of unknown function (DUF2953); Region: DUF2953; pfam11167
1147129002867	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
1147129002868	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1147129002869	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1147129002870	putative active site [active]
1147129002871	catalytic site [active]
1147129002872	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1147129002873	putative active site [active]
1147129002874	catalytic site [active]
1147129002875	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1147129002876	putative deacylase active site [active]
1147129002877	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1147129002878	metal binding site 2 [ion binding]; metal-binding site
1147129002879	putative DNA binding helix; other site
1147129002880	metal binding site 1 [ion binding]; metal-binding site
1147129002881	dimer interface [polypeptide binding]; other site
1147129002882	structural Zn2+ binding site [ion binding]; other site
1147129002883	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1147129002884	Zn2+ binding site [ion binding]; other site
1147129002885	Mg2+ binding site [ion binding]; other site
1147129002886	EDD domain protein, DegV family; Region: DegV; TIGR00762
1147129002887	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1147129002888	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1147129002889	active site 1 [active]
1147129002890	dimer interface [polypeptide binding]; other site
1147129002891	hexamer interface [polypeptide binding]; other site
1147129002892	active site 2 [active]
1147129002893	EcsC protein family; Region: EcsC; pfam12787
1147129002894	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1147129002895	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1147129002896	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
1147129002897	YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477
1147129002898	[2Fe-2S] cluster binding site [ion binding]; other site
1147129002899	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1147129002900	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
1147129002901	active site
1147129002902	dimerization interface [polypeptide binding]; other site
1147129002903	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1147129002904	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1147129002905	metal binding site [ion binding]; metal-binding site
1147129002906	active site
1147129002907	I-site; other site
1147129002908	Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235
1147129002909	intersubunit interface [polypeptide binding]; other site
1147129002910	active site
1147129002911	Zn2+ binding site [ion binding]; other site
1147129002912	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
1147129002913	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1147129002914	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1147129002915	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1147129002916	Spore germination protein; Region: Spore_permease; cl17796
1147129002917	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1147129002918	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1147129002919	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1147129002920	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1147129002921	putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055
1147129002922	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147129002923	FeS/SAM binding site; other site
1147129002924	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
1147129002925	putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054
1147129002926	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147129002927	FeS/SAM binding site; other site
1147129002928	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1147129002929	GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451
1147129002930	GIY-YIG motif/motif A; other site
1147129002931	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1147129002932	CoenzymeA binding site [chemical binding]; other site
1147129002933	subunit interaction site [polypeptide binding]; other site
1147129002934	PHB binding site; other site
1147129002935	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
1147129002936	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
1147129002937	metal binding site [ion binding]; metal-binding site
1147129002938	substrate binding pocket [chemical binding]; other site
1147129002939	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640
1147129002940	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1147129002941	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
1147129002942	acyl-activating enzyme (AAE) consensus motif; other site
1147129002943	putative AMP binding site [chemical binding]; other site
1147129002944	putative active site [active]
1147129002945	putative CoA binding site [chemical binding]; other site
1147129002946	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1147129002947	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
1147129002948	substrate binding site [chemical binding]; other site
1147129002949	oxyanion hole (OAH) forming residues; other site
1147129002950	trimer interface [polypeptide binding]; other site
1147129002951	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
1147129002952	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1147129002953	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165
1147129002954	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
1147129002955	dimer interface [polypeptide binding]; other site
1147129002956	tetramer interface [polypeptide binding]; other site
1147129002957	PYR/PP interface [polypeptide binding]; other site
1147129002958	TPP binding site [chemical binding]; other site
1147129002959	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
1147129002960	TPP-binding site; other site
1147129002961	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1147129002962	isocitrate dehydrogenase; Validated; Region: PRK08299
1147129002963	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147129002964	H+ Antiporter protein; Region: 2A0121; TIGR00900
1147129002965	putative substrate translocation pore; other site
1147129002966	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147129002967	GTPase RsgA; Reviewed; Region: PRK01889
1147129002968	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1147129002969	RNA binding site [nucleotide binding]; other site
1147129002970	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1147129002971	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1147129002972	GTP/Mg2+ binding site [chemical binding]; other site
1147129002973	G4 box; other site
1147129002974	G5 box; other site
1147129002975	G1 box; other site
1147129002976	Switch I region; other site
1147129002977	G2 box; other site
1147129002978	G3 box; other site
1147129002979	Switch II region; other site
1147129002980	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
1147129002981	Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620
1147129002982	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1147129002983	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147129002984	S-adenosylmethionine binding site [chemical binding]; other site
1147129002985	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1147129002986	active site
1147129002987	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1147129002988	active site
1147129002989	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1147129002990	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
1147129002991	putative metal binding site; other site
1147129002992	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147129002993	binding surface
1147129002994	TPR motif; other site
1147129002995	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147129002996	binding surface
1147129002997	TPR motif; other site
1147129002998	Disaggregatase related repeat; Region: Disaggr_repeat; pfam06848
1147129002999	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
1147129003000	putative metal binding site; other site
1147129003001	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147129003002	binding surface
1147129003003	TPR motif; other site
1147129003004	TPR repeat; Region: TPR_11; pfam13414
1147129003005	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147129003006	binding surface
1147129003007	TPR motif; other site
1147129003008	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1147129003009	active site
1147129003010	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
1147129003011	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1147129003012	PAS domain; Region: PAS; smart00091
1147129003013	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1147129003014	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1147129003015	dimer interface [polypeptide binding]; other site
1147129003016	phosphorylation site [posttranslational modification]
1147129003017	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147129003018	ATP binding site [chemical binding]; other site
1147129003019	Mg2+ binding site [ion binding]; other site
1147129003020	G-X-G motif; other site
1147129003021	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1147129003022	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129003023	active site
1147129003024	phosphorylation site [posttranslational modification]
1147129003025	intermolecular recognition site; other site
1147129003026	dimerization interface [polypeptide binding]; other site
1147129003027	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1147129003028	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1147129003029	active site
1147129003030	tetramer interface; other site
1147129003031	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1147129003032	Chain length determinant protein; Region: Wzz; cl15801
1147129003033	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
1147129003034	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
1147129003035	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
1147129003036	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
1147129003037	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1147129003038	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1147129003039	NAD binding site [chemical binding]; other site
1147129003040	substrate binding site [chemical binding]; other site
1147129003041	homodimer interface [polypeptide binding]; other site
1147129003042	active site
1147129003043	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1147129003044	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1147129003045	substrate binding site; other site
1147129003046	tetramer interface; other site
1147129003047	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1147129003048	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1147129003049	inhibitor-cofactor binding pocket; inhibition site
1147129003050	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147129003051	catalytic residue [active]
1147129003052	colanic acid exporter; Provisional; Region: PRK10459
1147129003053	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
1147129003054	Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; pfam13579
1147129003055	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1147129003056	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1147129003057	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1147129003058	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1147129003059	NAD(P) binding site [chemical binding]; other site
1147129003060	active site
1147129003061	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
1147129003062	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1147129003063	NADP-binding site; other site
1147129003064	homotetramer interface [polypeptide binding]; other site
1147129003065	substrate binding site [chemical binding]; other site
1147129003066	homodimer interface [polypeptide binding]; other site
1147129003067	active site
1147129003068	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1147129003069	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
1147129003070	putative colanic acid biosynthesis protein; Provisional; Region: wcaD; cl08075
1147129003071	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1147129003072	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
1147129003073	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1147129003074	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
1147129003075	active site
1147129003076	Cupin domain; Region: Cupin_2; cl17218
1147129003077	hypothetical protein; Provisional; Region: PRK07206
1147129003078	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
1147129003079	WbqC-like protein family; Region: WbqC; pfam08889
1147129003080	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
1147129003081	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1147129003082	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1147129003083	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1147129003084	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1147129003085	NAD binding site [chemical binding]; other site
1147129003086	homodimer interface [polypeptide binding]; other site
1147129003087	active site
1147129003088	substrate binding site [chemical binding]; other site
1147129003089	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
1147129003090	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1147129003091	active site
1147129003092	substrate binding site [chemical binding]; other site
1147129003093	metal binding site [ion binding]; metal-binding site
1147129003094	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1147129003095	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1147129003096	metal binding site [ion binding]; metal-binding site
1147129003097	active site
1147129003098	I-site; other site
1147129003099	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
1147129003100	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1147129003101	Zn2+ binding site [ion binding]; other site
1147129003102	Mg2+ binding site [ion binding]; other site
1147129003103	YtxH-like protein; Region: YtxH; pfam12732
1147129003104	peroxiredoxin; Provisional; Region: PRK13189
1147129003105	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1147129003106	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1147129003107	PAS domain; Region: PAS_9; pfam13426
1147129003108	putative active site [active]
1147129003109	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1147129003110	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1147129003111	metal binding site [ion binding]; metal-binding site
1147129003112	active site
1147129003113	I-site; other site
1147129003114	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
1147129003115	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1147129003116	Zn2+ binding site [ion binding]; other site
1147129003117	Mg2+ binding site [ion binding]; other site
1147129003118	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
1147129003119	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
1147129003120	Sporulation and spore germination; Region: Germane; pfam10646
1147129003121	Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648
1147129003122	Uncharacterized conserved protein [Function unknown]; Region: COG3937
1147129003123	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1147129003124	ABC1 family; Region: ABC1; cl17513
1147129003125	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1147129003126	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1147129003127	CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein) [Energy production and conversion]; Region: CdhE; COG1456
1147129003128	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1147129003129	Domain of unknown function DUF21; Region: DUF21; pfam01595
1147129003130	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1147129003131	Transporter associated domain; Region: CorC_HlyC; pfam03471
1147129003132	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
1147129003133	B12 binding domain; Region: B12-binding; pfam02310
1147129003134	B12 binding site [chemical binding]; other site
1147129003135	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
1147129003136	FeS/SAM binding site; other site
1147129003137	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
1147129003138	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
1147129003139	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1147129003140	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1147129003141	metal binding site [ion binding]; metal-binding site
1147129003142	active site
1147129003143	I-site; other site
1147129003144	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1147129003145	AMP binding site [chemical binding]; other site
1147129003146	active site
1147129003147	CoA binding site [chemical binding]; other site
1147129003148	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1147129003149	acyl-activating enzyme (AAE) consensus motif; other site
1147129003150	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1147129003151	putative lipid kinase; Reviewed; Region: PRK13059
1147129003152	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1147129003153	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
1147129003154	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
1147129003155	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1147129003156	active site
1147129003157	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1147129003158	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1147129003159	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1147129003160	metal binding site [ion binding]; metal-binding site
1147129003161	active site
1147129003162	I-site; other site
1147129003163	hybrid cluster protein; Provisional; Region: PRK05290
1147129003164	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1147129003165	ACS interaction site; other site
1147129003166	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1147129003167	ACS interaction site; other site
1147129003168	CODH interaction site; other site
1147129003169	metal cluster binding site [ion binding]; other site
1147129003170	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1147129003171	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1147129003172	metal binding site [ion binding]; metal-binding site
1147129003173	active site
1147129003174	I-site; other site
1147129003175	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
1147129003176	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1147129003177	Zn2+ binding site [ion binding]; other site
1147129003178	Mg2+ binding site [ion binding]; other site
1147129003179	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1147129003180	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1147129003181	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
1147129003182	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1147129003183	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1147129003184	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1147129003185	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1147129003186	L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235
1147129003187	putative NAD(P) binding site [chemical binding]; other site
1147129003188	catalytic Zn binding site [ion binding]; other site
1147129003189	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1147129003190	dinuclear metal binding motif [ion binding]; other site
1147129003191	Predicted metal-binding protein (DUF2284); Region: DUF2284; pfam10050
1147129003192	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1147129003193	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
1147129003194	Flavoprotein; Region: Flavoprotein; pfam02441
1147129003195	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
1147129003196	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
1147129003197	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
1147129003198	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1147129003199	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1147129003200	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
1147129003201	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1147129003202	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1147129003203	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1147129003204	Walker A/P-loop; other site
1147129003205	ATP binding site [chemical binding]; other site
1147129003206	Q-loop/lid; other site
1147129003207	ABC transporter signature motif; other site
1147129003208	Walker B; other site
1147129003209	D-loop; other site
1147129003210	H-loop/switch region; other site
1147129003211	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1147129003212	Walker A/P-loop; other site
1147129003213	ATP binding site [chemical binding]; other site
1147129003214	Q-loop/lid; other site
1147129003215	ABC transporter signature motif; other site
1147129003216	Walker B; other site
1147129003217	D-loop; other site
1147129003218	H-loop/switch region; other site
1147129003219	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1147129003220	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1147129003221	ligand binding site [chemical binding]; other site
1147129003222	flexible hinge region; other site
1147129003223	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
1147129003224	FMN-binding domain; Region: FMN_bind; pfam04205
1147129003225	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
1147129003226	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1147129003227	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
1147129003228	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
1147129003229	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1147129003230	Predicted transcriptional regulators [Transcription]; Region: COG1733
1147129003231	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1147129003232	CmuA_CmuC_like: uncharacterized protein family similar to uroporphyrinogen decarboxylase (URO-D) and the methyltransferases CmuA and CmuC; Region: CmuA_CmuC_like; cd03308
1147129003233	methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370
1147129003234	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1147129003235	B12 binding site [chemical binding]; other site
1147129003236	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1147129003237	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1147129003238	ligand binding site [chemical binding]; other site
1147129003239	flexible hinge region; other site
1147129003240	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1147129003241	non-specific DNA interactions [nucleotide binding]; other site
1147129003242	DNA binding site [nucleotide binding]
1147129003243	sequence specific DNA binding site [nucleotide binding]; other site
1147129003244	putative cAMP binding site [chemical binding]; other site
1147129003245	FMN-binding domain; Region: FMN_bind; pfam04205
1147129003246	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1147129003247	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1147129003248	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
1147129003249	reductive dehalogenase; Region: RDH; TIGR02486
1147129003250	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1147129003251	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1147129003252	ligand binding site [chemical binding]; other site
1147129003253	flexible hinge region; other site
1147129003254	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1147129003255	putative switch regulator; other site
1147129003256	non-specific DNA interactions [nucleotide binding]; other site
1147129003257	DNA binding site [nucleotide binding]
1147129003258	sequence specific DNA binding site [nucleotide binding]; other site
1147129003259	putative cAMP binding site [chemical binding]; other site
1147129003260	reductive dehalogenase; Region: RDH; TIGR02486
1147129003261	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
1147129003262	Protein of unknown function (DUF3102); Region: DUF3102; pfam11300
1147129003263	VanZ like family; Region: VanZ; pfam04892
1147129003264	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1147129003265	dimer interface [polypeptide binding]; other site
1147129003266	phosphorylation site [posttranslational modification]
1147129003267	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147129003268	ATP binding site [chemical binding]; other site
1147129003269	Mg2+ binding site [ion binding]; other site
1147129003270	G-X-G motif; other site
1147129003271	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1147129003272	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129003273	active site
1147129003274	phosphorylation site [posttranslational modification]
1147129003275	intermolecular recognition site; other site
1147129003276	dimerization interface [polypeptide binding]; other site
1147129003277	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1147129003278	DNA binding site [nucleotide binding]
1147129003279	Predicted transcriptional regulators [Transcription]; Region: COG1695
1147129003280	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1147129003281	Protein of unknown function (DUF1048); Region: DUF1048; pfam06304
1147129003282	Protein of unknown function (DUF1048); Region: DUF1048; pfam06304
1147129003283	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1147129003284	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1147129003285	Walker A/P-loop; other site
1147129003286	ATP binding site [chemical binding]; other site
1147129003287	Q-loop/lid; other site
1147129003288	ABC transporter signature motif; other site
1147129003289	Walker B; other site
1147129003290	D-loop; other site
1147129003291	H-loop/switch region; other site
1147129003292	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1147129003293	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1147129003294	Methyltransferase domain; Region: Methyltransf_11; pfam08241
1147129003295	methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535
1147129003296	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
1147129003297	substrate binding pocket [chemical binding]; other site
1147129003298	dimer interface [polypeptide binding]; other site
1147129003299	inhibitor binding site; inhibition site
1147129003300	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
1147129003301	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
1147129003302	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1147129003303	B12 binding site [chemical binding]; other site
1147129003304	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1147129003305	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1147129003306	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147129003307	DNA-binding site [nucleotide binding]; DNA binding site
1147129003308	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1147129003309	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
1147129003310	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1147129003311	B12 binding site [chemical binding]; other site
1147129003312	DNA polymerase IV; Reviewed; Region: PRK03103
1147129003313	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1147129003314	active site
1147129003315	DNA binding site [nucleotide binding]
1147129003316	Uncharacterized conserved protein [Function unknown]; Region: COG2135
1147129003317	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1147129003318	Transposase; Region: HTH_Tnp_1; pfam01527
1147129003319	putative transposase OrfB; Reviewed; Region: PHA02517
1147129003320	HTH-like domain; Region: HTH_21; pfam13276
1147129003321	Integrase core domain; Region: rve; pfam00665
1147129003322	Integrase core domain; Region: rve_3; pfam13683
1147129003323	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
1147129003324	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1147129003325	motif II; other site
1147129003326	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
1147129003327	methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370
1147129003328	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
1147129003329	B12 binding site [chemical binding]; other site
1147129003330	cobalt ligand [ion binding]; other site
1147129003331	Sensory domain found in PocR; Region: PocR; pfam10114
1147129003332	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
1147129003333	Histidine kinase; Region: His_kinase; pfam06580
1147129003334	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1147129003335	Mg2+ binding site [ion binding]; other site
1147129003336	G-X-G motif; other site
1147129003337	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
1147129003338	non-specific DNA interactions [nucleotide binding]; other site
1147129003339	DNA binding site [nucleotide binding]
1147129003340	sequence specific DNA binding site [nucleotide binding]; other site
1147129003341	putative cAMP binding site [chemical binding]; other site
1147129003342	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1147129003343	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1147129003344	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
1147129003345	ApbE family; Region: ApbE; pfam02424
1147129003346	N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cl02206
1147129003347	FMN-binding domain; Region: FMN_bind; pfam04205
1147129003348	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1147129003349	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1147129003350	reductive dehalogenase; Region: RDH; TIGR02486
1147129003351	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
1147129003352	Protein of unknown function (DUF1638); Region: DUF1638; pfam07796
1147129003353	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1147129003354	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
1147129003355	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1147129003356	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
1147129003357	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1147129003358	active site
1147129003359	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1147129003360	pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188
1147129003361	Int/Topo IB signature motif; other site
1147129003362	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1147129003363	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1147129003364	active site
1147129003365	DNA binding site [nucleotide binding]
1147129003366	Int/Topo IB signature motif; other site
1147129003367	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
1147129003368	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1147129003369	active site
1147129003370	DNA binding site [nucleotide binding]
1147129003371	Int/Topo IB signature motif; other site
1147129003372	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
1147129003373	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
1147129003374	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1147129003375	putative active site [active]
1147129003376	putative NTP binding site [chemical binding]; other site
1147129003377	putative nucleic acid binding site [nucleotide binding]; other site
1147129003378	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1147129003379	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1147129003380	putative active site [active]
1147129003381	putative NTP binding site [chemical binding]; other site
1147129003382	putative nucleic acid binding site [nucleotide binding]; other site
1147129003383	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1147129003384	active site
1147129003385	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
1147129003386	putative transposase OrfB; Reviewed; Region: PHA02517
1147129003387	HTH-like domain; Region: HTH_21; pfam13276
1147129003388	Integrase core domain; Region: rve; pfam00665
1147129003389	Integrase core domain; Region: rve_3; pfam13683
1147129003390	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1147129003391	Transposase; Region: HTH_Tnp_1; pfam01527
1147129003392	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1147129003393	Protein of unknown function (DUF1638); Region: DUF1638; pfam07796
1147129003394	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147129003395	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1147129003396	Coenzyme A binding pocket [chemical binding]; other site
1147129003397	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1147129003398	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1147129003399	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1147129003400	dimerization interface [polypeptide binding]; other site
1147129003401	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
1147129003402	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147129003403	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1147129003404	active site
1147129003405	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1147129003406	EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737
1147129003407	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
1147129003408	HEAT repeats; Region: HEAT_2; pfam13646
1147129003409	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
1147129003410	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
1147129003411	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
1147129003412	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; cl17802
1147129003413	DDE superfamily endonuclease; Region: DDE_5; cl17874
1147129003414	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1147129003415	HEAT-like repeat; Region: HEAT_EZ; pfam13513
1147129003416	EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737
1147129003417	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
1147129003418	HEAT repeats; Region: HEAT_2; pfam13646
1147129003419	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1147129003420	MarR family; Region: MarR_2; pfam12802
1147129003421	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1147129003422	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
1147129003423	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1147129003424	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
1147129003425	substrate binding pocket [chemical binding]; other site
1147129003426	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
1147129003427	B12 binding site [chemical binding]; other site
1147129003428	cobalt ligand [ion binding]; other site
1147129003429	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
1147129003430	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1147129003431	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1147129003432	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1147129003433	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1147129003434	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1147129003435	dimer interface [polypeptide binding]; other site
1147129003436	active site
1147129003437	Transposase [DNA replication, recombination, and repair]; Region: COG5421
1147129003438	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1147129003439	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1147129003440	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1147129003441	Uncharacterized protein conserved in archaea (DUF2115); Region: DUF2115; cl01681
1147129003442	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147129003443	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1147129003444	Coenzyme A binding pocket [chemical binding]; other site
1147129003445	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
1147129003446	Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139
1147129003447	putative FMN binding site [chemical binding]; other site
1147129003448	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1147129003449	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1147129003450	Predicted metal-binding protein (DUF2284); Region: DUF2284; cl02248
1147129003451	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
1147129003452	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
1147129003453	active site
1147129003454	FMN binding site [chemical binding]; other site
1147129003455	substrate binding site [chemical binding]; other site
1147129003456	putative catalytic residues [active]
1147129003457	Protein of unknown function (DUF1638); Region: DUF1638; pfam07796
1147129003458	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1147129003459	Helix-turn-helix domain; Region: HTH_36; pfam13730
1147129003460	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
1147129003461	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1147129003462	Walker A motif; other site
1147129003463	ATP binding site [chemical binding]; other site
1147129003464	Walker B motif; other site
1147129003465	CHC2 zinc finger; Region: zf-CHC2; cl17510
1147129003466	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
1147129003467	Toprim-like; Region: Toprim_2; pfam13155
1147129003468	active site
1147129003469	metal binding site [ion binding]; metal-binding site
1147129003470	Sel1-like repeats; Region: SEL1; smart00671
1147129003471	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1147129003472	Sel1-like repeats; Region: SEL1; smart00671
1147129003473	Sel1-like repeats; Region: SEL1; smart00671
1147129003474	Sel1-like repeats; Region: SEL1; smart00671
1147129003475	Sel1-like repeats; Region: SEL1; smart00671
1147129003476	Sel1-like repeats; Region: SEL1; smart00671
1147129003477	Sel1-like repeats; Region: SEL1; smart00671
1147129003478	Domain of unknown function (DUF3846); Region: DUF3846; pfam12957
1147129003479	Fic family protein [Function unknown]; Region: COG3177
1147129003480	Fic/DOC family; Region: Fic; pfam02661
1147129003481	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1147129003482	Peptidase family M23; Region: Peptidase_M23; pfam01551
1147129003483	Protein of unknown function (DUF3849); Region: DUF3849; pfam12960
1147129003484	Protein of unknown function, DUF484; Region: DUF484; cl17449
1147129003485	AAA-like domain; Region: AAA_10; pfam12846
1147129003486	Domain of unknown function DUF87; Region: DUF87; pfam01935
1147129003487	Fic/DOC family; Region: Fic; cl00960
1147129003488	HEPN domain; Region: HEPN; pfam05168
1147129003489	HEPN domain; Region: HEPN; pfam05168
1147129003490	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1147129003491	active site
1147129003492	NTP binding site [chemical binding]; other site
1147129003493	metal binding triad [ion binding]; metal-binding site
1147129003494	antibiotic binding site [chemical binding]; other site
1147129003495	Protein of unknown function (DUF3852); Region: DUF3852; pfam12963
1147129003496	Domain of unknown function (DUF4320); Region: DUF4320; pfam14208
1147129003497	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1147129003498	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1147129003499	Walker A motif; other site
1147129003500	ATP binding site [chemical binding]; other site
1147129003501	Walker B motif; other site
1147129003502	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
1147129003503	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1147129003504	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1147129003505	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
1147129003506	SpoVG; Region: SpoVG; pfam04026
1147129003507	SpoVG; Region: SpoVG; pfam04026
1147129003508	YodL-like; Region: YodL; pfam14191
1147129003509	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
1147129003510	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
1147129003511	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
1147129003512	Antirestriction protein (ArdA); Region: ArdA; cl01953
1147129003513	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
1147129003514	cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359
1147129003515	Domain of unknown function (DUF4320); Region: DUF4320; pfam14208
1147129003516	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1147129003517	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1147129003518	Walker A motif; other site
1147129003519	ATP binding site [chemical binding]; other site
1147129003520	Walker B motif; other site
1147129003521	AAA domain; Region: AAA_31; pfam13614
1147129003522	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
1147129003523	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
1147129003524	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1147129003525	Antirestriction protein (ArdA); Region: ArdA; cl01953
1147129003526	Antirestriction protein (ArdA); Region: ArdA; cl01953
1147129003527	Part of AAA domain; Region: AAA_19; pfam13245
1147129003528	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1147129003529	AAA ATPase domain; Region: AAA_15; pfam13175
1147129003530	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
1147129003531	putative active site [active]
1147129003532	putative metal-binding site [ion binding]; other site
1147129003533	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1147129003534	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1147129003535	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
1147129003536	Helix-turn-helix domain; Region: HTH_17; pfam12728
1147129003537	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1147129003538	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1147129003539	catalytic residues [active]
1147129003540	catalytic nucleophile [active]
1147129003541	Recombinase; Region: Recombinase; pfam07508
1147129003542	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1147129003543	Recombinase; Region: Recombinase; pfam07508
1147129003544	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1147129003545	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1147129003546	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1147129003547	catalytic residues [active]
1147129003548	catalytic nucleophile [active]
1147129003549	Recombinase; Region: Recombinase; pfam07508
1147129003550	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1147129003551	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1147129003552	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1147129003553	catalytic residues [active]
1147129003554	catalytic nucleophile [active]
1147129003555	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1147129003556	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1147129003557	DNA binding residues [nucleotide binding]
1147129003558	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1147129003559	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147129003560	non-specific DNA binding site [nucleotide binding]; other site
1147129003561	salt bridge; other site
1147129003562	sequence-specific DNA binding site [nucleotide binding]; other site
1147129003563	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1147129003564	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1147129003565	ABC1 family; Region: ABC1; pfam03109
1147129003566	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1147129003567	active site
1147129003568	ATP binding site [chemical binding]; other site
1147129003569	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
1147129003570	IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483
1147129003571	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147129003572	Walker A motif; other site
1147129003573	ATP binding site [chemical binding]; other site
1147129003574	Walker B motif; other site
1147129003575	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1147129003576	Integrase core domain; Region: rve; pfam00665
1147129003577	Uncharacterized conserved protein [Function unknown]; Region: COG3937
1147129003578	FMN-binding domain; Region: FMN_bind; cl01081
1147129003579	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
1147129003580	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1147129003581	dimer interface [polypeptide binding]; other site
1147129003582	active site
1147129003583	CoA binding pocket [chemical binding]; other site
1147129003584	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1147129003585	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147129003586	putative substrate translocation pore; other site
1147129003587	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1147129003588	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1147129003589	carboxyltransferase (CT) interaction site; other site
1147129003590	biotinylation site [posttranslational modification]; other site
1147129003591	HlyD family secretion protein; Region: HlyD_3; pfam13437
1147129003592	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1147129003593	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1147129003594	HlyD family secretion protein; Region: HlyD_3; pfam13437
1147129003595	EDD domain protein, DegV family; Region: DegV; TIGR00762
1147129003596	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1147129003597	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
1147129003598	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
1147129003599	RTX iron-regulated protein FrpC; Region: FrpC; pfam06901
1147129003600	Helix-turn-helix domain; Region: HTH_36; pfam13730
1147129003601	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
1147129003602	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
1147129003603	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
1147129003604	Toprim-like; Region: Toprim_2; pfam13155
1147129003605	active site
1147129003606	metal binding site [ion binding]; metal-binding site
1147129003607	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1147129003608	Sel1-like repeats; Region: SEL1; smart00671
1147129003609	Sel1-like repeats; Region: SEL1; smart00671
1147129003610	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1147129003611	AAA domain; Region: AAA_23; pfam13476
1147129003612	Walker A/P-loop; other site
1147129003613	ATP binding site [chemical binding]; other site
1147129003614	AAA domain; Region: AAA_13; pfam13166
1147129003615	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1147129003616	Q-loop/lid; other site
1147129003617	ABC transporter signature motif; other site
1147129003618	Walker B; other site
1147129003619	D-loop; other site
1147129003620	H-loop/switch region; other site
1147129003621	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1147129003622	ATP binding site [chemical binding]; other site
1147129003623	putative Mg++ binding site [ion binding]; other site
1147129003624	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1147129003625	nucleotide binding region [chemical binding]; other site
1147129003626	ATP-binding site [chemical binding]; other site
1147129003627	Domain of unknown function (DUF3846); Region: DUF3846; pfam12957
1147129003628	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
1147129003629	Mg binding site [ion binding]; other site
1147129003630	nucleotide binding site [chemical binding]; other site
1147129003631	putative protofilament interface [polypeptide binding]; other site
1147129003632	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1147129003633	putative active site pocket [active]
1147129003634	dimerization interface [polypeptide binding]; other site
1147129003635	putative catalytic residue [active]
1147129003636	Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224
1147129003637	AAA-like domain; Region: AAA_10; pfam12846
1147129003638	Domain of unknown function DUF87; Region: DUF87; pfam01935
1147129003639	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147129003640	non-specific DNA binding site [nucleotide binding]; other site
1147129003641	salt bridge; other site
1147129003642	sequence-specific DNA binding site [nucleotide binding]; other site
1147129003643	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
1147129003644	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1147129003645	cofactor binding site; other site
1147129003646	DNA binding site [nucleotide binding]
1147129003647	substrate interaction site [chemical binding]; other site
1147129003648	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1147129003649	Protein of unknown function (DUF3852); Region: DUF3852; pfam12963
1147129003650	Domain of unknown function (DUF4320); Region: DUF4320; pfam14208
1147129003651	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1147129003652	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1147129003653	Walker A motif; other site
1147129003654	ATP binding site [chemical binding]; other site
1147129003655	Walker B motif; other site
1147129003656	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1147129003657	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
1147129003658	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1147129003659	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
1147129003660	YodL-like; Region: YodL; pfam14191
1147129003661	S-layer homology domain; Region: SLH; pfam00395
1147129003662	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
1147129003663	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
1147129003664	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
1147129003665	Domain of unknown function (DUF4314); Region: DUF4314; pfam14192
1147129003666	RNA polymerase factor sigma-70; Validated; Region: PRK06811
1147129003667	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1147129003668	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1147129003669	DNA binding residues [nucleotide binding]
1147129003670	TRAM domain; Region: TRAM; cl01282
1147129003671	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1147129003672	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147129003673	S-adenosylmethionine binding site [chemical binding]; other site
1147129003674	CAAX protease self-immunity; Region: Abi; pfam02517
1147129003675	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
1147129003676	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
1147129003677	active site
1147129003678	catalytic residues [active]
1147129003679	metal binding site [ion binding]; metal-binding site
1147129003680	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1147129003681	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1147129003682	GatB domain; Region: GatB_Yqey; smart00845
1147129003683	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1147129003684	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1147129003685	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1147129003686	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1147129003687	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1147129003688	nucleotide binding pocket [chemical binding]; other site
1147129003689	K-X-D-G motif; other site
1147129003690	catalytic site [active]
1147129003691	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1147129003692	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1147129003693	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1147129003694	Dimer interface [polypeptide binding]; other site
1147129003695	BRCT sequence motif; other site
1147129003696	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1147129003697	Part of AAA domain; Region: AAA_19; pfam13245
1147129003698	Family description; Region: UvrD_C_2; pfam13538
1147129003699	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533
1147129003700	homodimer interface [polypeptide binding]; other site
1147129003701	metal binding site [ion binding]; metal-binding site
1147129003702	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
1147129003703	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
1147129003704	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1147129003705	metal binding site [ion binding]; metal-binding site
1147129003706	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1147129003707	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1147129003708	substrate binding site [chemical binding]; other site
1147129003709	glutamase interaction surface [polypeptide binding]; other site
1147129003710	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1147129003711	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
1147129003712	catalytic residues [active]
1147129003713	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
1147129003714	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1147129003715	putative active site [active]
1147129003716	oxyanion strand; other site
1147129003717	catalytic triad [active]
1147129003718	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1147129003719	putative active site pocket [active]
1147129003720	4-fold oligomerization interface [polypeptide binding]; other site
1147129003721	metal binding residues [ion binding]; metal-binding site
1147129003722	3-fold/trimer interface [polypeptide binding]; other site
1147129003723	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1147129003724	histidinol dehydrogenase; Region: hisD; TIGR00069
1147129003725	NAD binding site [chemical binding]; other site
1147129003726	dimerization interface [polypeptide binding]; other site
1147129003727	product binding site; other site
1147129003728	substrate binding site [chemical binding]; other site
1147129003729	zinc binding site [ion binding]; other site
1147129003730	catalytic residues [active]
1147129003731	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
1147129003732	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
1147129003733	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1147129003734	ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443
1147129003735	dimer interface [polypeptide binding]; other site
1147129003736	motif 1; other site
1147129003737	active site
1147129003738	motif 2; other site
1147129003739	motif 3; other site
1147129003740	Trp repressor protein; Region: Trp_repressor; cl17266
1147129003741	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
1147129003742	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1147129003743	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147129003744	homodimer interface [polypeptide binding]; other site
1147129003745	catalytic residue [active]
1147129003746	Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977
1147129003747	ArsC family; Region: ArsC; pfam03960
1147129003748	catalytic residue [active]
1147129003749	hypothetical protein; Provisional; Region: PRK13665
1147129003750	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
1147129003751	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
1147129003752	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1147129003753	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1147129003754	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1147129003755	catalytic residue [active]
1147129003756	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1147129003757	dinuclear metal binding motif [ion binding]; other site
1147129003758	Protein of unknown function (DUF3793); Region: DUF3793; pfam12672
1147129003759	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
1147129003760	C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882
1147129003761	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
1147129003762	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1147129003763	acyl-activating enzyme (AAE) consensus motif; other site
1147129003764	AMP binding site [chemical binding]; other site
1147129003765	active site
1147129003766	CoA binding site [chemical binding]; other site
1147129003767	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1147129003768	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1147129003769	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1147129003770	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1147129003771	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1147129003772	Flavoprotein; Region: Flavoprotein; pfam02441
1147129003773	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1147129003774	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
1147129003775	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1147129003776	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1147129003777	catalytic site [active]
1147129003778	G-X2-G-X-G-K; other site
1147129003779	hypothetical protein; Provisional; Region: PRK04323
1147129003780	hypothetical protein; Provisional; Region: PRK11820
1147129003781	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
1147129003782	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
1147129003783	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
1147129003784	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1147129003785	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147129003786	homodimer interface [polypeptide binding]; other site
1147129003787	catalytic residue [active]
1147129003788	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1147129003789	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1147129003790	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1147129003791	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
1147129003792	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1147129003793	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1147129003794	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1147129003795	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1147129003796	motif II; other site
1147129003797	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1147129003798	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
1147129003799	Domain of unknown function (DUF814); Region: DUF814; pfam05670
1147129003800	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1147129003801	active site
1147129003802	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
1147129003803	PAS domain S-box; Region: sensory_box; TIGR00229
1147129003804	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1147129003805	putative active site [active]
1147129003806	heme pocket [chemical binding]; other site
1147129003807	GAF domain; Region: GAF; pfam01590
1147129003808	GAF domain; Region: GAF_2; pfam13185
1147129003809	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1147129003810	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1147129003811	metal binding site [ion binding]; metal-binding site
1147129003812	active site
1147129003813	I-site; other site
1147129003814	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1147129003815	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1147129003816	metal binding site [ion binding]; metal-binding site
1147129003817	active site
1147129003818	I-site; other site
1147129003819	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1147129003820	active site
1147129003821	dimer interface [polypeptide binding]; other site
1147129003822	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
1147129003823	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
1147129003824	heterodimer interface [polypeptide binding]; other site
1147129003825	active site
1147129003826	FMN binding site [chemical binding]; other site
1147129003827	homodimer interface [polypeptide binding]; other site
1147129003828	substrate binding site [chemical binding]; other site
1147129003829	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
1147129003830	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
1147129003831	FAD binding pocket [chemical binding]; other site
1147129003832	FAD binding motif [chemical binding]; other site
1147129003833	phosphate binding motif [ion binding]; other site
1147129003834	beta-alpha-beta structure motif; other site
1147129003835	NAD binding pocket [chemical binding]; other site
1147129003836	Iron coordination center [ion binding]; other site
1147129003837	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1147129003838	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1147129003839	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1147129003840	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1147129003841	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1147129003842	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1147129003843	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1147129003844	IMP binding site; other site
1147129003845	dimer interface [polypeptide binding]; other site
1147129003846	interdomain contacts; other site
1147129003847	partial ornithine binding site; other site
1147129003848	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1147129003849	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
1147129003850	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1147129003851	catalytic site [active]
1147129003852	subunit interface [polypeptide binding]; other site
1147129003853	dihydroorotase; Validated; Region: pyrC; PRK09357
1147129003854	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1147129003855	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1147129003856	active site
1147129003857	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1147129003858	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1147129003859	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1147129003860	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1147129003861	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1147129003862	active site
1147129003863	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1147129003864	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1147129003865	RNA binding surface [nucleotide binding]; other site
1147129003866	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1147129003867	active site
1147129003868	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
1147129003869	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
1147129003870	Propanediol utilisation protein PduL; Region: PduL; pfam06130
1147129003871	Propanediol utilisation protein PduL; Region: PduL; pfam06130
1147129003872	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
1147129003873	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
1147129003874	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1147129003875	catalytic residue [active]
1147129003876	putative membrane fusion protein; Region: TIGR02828
1147129003877	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1147129003878	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
1147129003879	Protein implicated in RNA metabolism, contains PRC-barrel domain [General    function prediction only]; Region: COG1873; cl17889
1147129003880	sporulation sigma factor SigG; Reviewed; Region: PRK08215
1147129003881	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1147129003882	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1147129003883	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1147129003884	DNA binding residues [nucleotide binding]
1147129003885	sporulation sigma factor SigE; Reviewed; Region: PRK08301
1147129003886	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1147129003887	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1147129003888	DNA binding residues [nucleotide binding]
1147129003889	Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419
1147129003890	sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854
1147129003891	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1147129003892	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1147129003893	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1147129003894	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1147129003895	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1147129003896	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1147129003897	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1147129003898	Protein of unknown function (DUF3102); Region: DUF3102; pfam11300
1147129003899	cell division protein FtsZ; Validated; Region: PRK09330
1147129003900	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1147129003901	nucleotide binding site [chemical binding]; other site
1147129003902	SulA interaction site; other site
1147129003903	Protein of unknown function (DUF1290); Region: DUF1290; pfam06947
1147129003904	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1147129003905	Cell division protein FtsQ; Region: FtsQ; pfam03799
1147129003906	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1147129003907	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1147129003908	hinge; other site
1147129003909	active site
1147129003910	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
1147129003911	FAD binding domain; Region: FAD_binding_4; pfam01565
1147129003912	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1147129003913	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1147129003914	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1147129003915	active site
1147129003916	homodimer interface [polypeptide binding]; other site
1147129003917	cell division protein FtsW; Region: ftsW; TIGR02614
1147129003918	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106
1147129003919	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1147129003920	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1147129003921	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1147129003922	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1147129003923	Mg++ binding site [ion binding]; other site
1147129003924	putative catalytic motif [active]
1147129003925	putative substrate binding site [chemical binding]; other site
1147129003926	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1147129003927	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1147129003928	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1147129003929	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1147129003930	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1147129003931	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1147129003932	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1147129003933	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1147129003934	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
1147129003935	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1147129003936	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1147129003937	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
1147129003938	Septum formation initiator; Region: DivIC; cl17659
1147129003939	MraW methylase family; Region: Methyltransf_5; pfam01795
1147129003940	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1147129003941	cell division protein MraZ; Reviewed; Region: PRK00326
1147129003942	MraZ protein; Region: MraZ; pfam02381
1147129003943	MraZ protein; Region: MraZ; pfam02381
1147129003944	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1147129003945	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
1147129003946	active site
1147129003947	nucleophile elbow; other site
1147129003948	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
1147129003949	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1147129003950	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1147129003951	metal binding site 2 [ion binding]; metal-binding site
1147129003952	putative DNA binding helix; other site
1147129003953	metal binding site 1 [ion binding]; metal-binding site
1147129003954	dimer interface [polypeptide binding]; other site
1147129003955	structural Zn2+ binding site [ion binding]; other site
1147129003956	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1147129003957	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1147129003958	histidinol-phosphatase; Provisional; Region: PRK07328
1147129003959	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
1147129003960	dimer interface [polypeptide binding]; other site
1147129003961	active site
1147129003962	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
1147129003963	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
1147129003964	Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704
1147129003965	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1147129003966	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1147129003967	Protein of unknown function (DUF342); Region: DUF342; pfam03961
1147129003968	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1147129003969	selenophosphate synthetase; Provisional; Region: PRK00943
1147129003970	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
1147129003971	dimerization interface [polypeptide binding]; other site
1147129003972	putative ATP binding site [chemical binding]; other site
1147129003973	selenocysteine synthase; Provisional; Region: PRK04311
1147129003974	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
1147129003975	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1147129003976	catalytic residue [active]
1147129003977	Negative regulator of genetic competence (MecA); Region: MecA; cl02022
1147129003978	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
1147129003979	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
1147129003980	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1147129003981	Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815
1147129003982	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
1147129003983	flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506
1147129003984	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1147129003985	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
1147129003986	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636
1147129003987	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1147129003988	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1147129003989	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
1147129003990	flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618
1147129003991	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
1147129003992	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
1147129003993	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1147129003994	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1147129003995	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1147129003996	DNA binding residues [nucleotide binding]
1147129003997	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
1147129003998	Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871
1147129003999	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
1147129004000	CheC-like family; Region: CheC; pfam04509
1147129004001	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1147129004002	CheC-like family; Region: CheC; pfam04509
1147129004003	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
1147129004004	Flagellar protein YcgR; Region: YcgR_2; pfam12945
1147129004005	PilZ domain; Region: PilZ; pfam07238
1147129004006	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1147129004007	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
1147129004008	P-loop; other site
1147129004009	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
1147129004010	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1147129004011	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
1147129004012	FHIPEP family; Region: FHIPEP; pfam00771
1147129004013	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
1147129004014	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
1147129004015	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
1147129004016	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
1147129004017	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
1147129004018	flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500
1147129004019	Response regulator receiver domain; Region: Response_reg; pfam00072
1147129004020	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129004021	active site
1147129004022	phosphorylation site [posttranslational modification]
1147129004023	intermolecular recognition site; other site
1147129004024	dimerization interface [polypeptide binding]; other site
1147129004025	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1147129004026	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1147129004027	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1147129004028	flagellar motor switch protein; Validated; Region: PRK08119
1147129004029	CheC-like family; Region: CheC; pfam04509
1147129004030	flagellar motor switch protein FliN; Region: fliN; TIGR02480
1147129004031	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
1147129004032	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
1147129004033	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
1147129004034	Flagellar protein (FlbD); Region: FlbD; pfam06289
1147129004035	flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497
1147129004036	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1147129004037	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
1147129004038	Walker A motif/ATP binding site; other site
1147129004039	Walker B motif; other site
1147129004040	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1147129004041	type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499
1147129004042	Flagellar assembly protein FliH; Region: FliH; pfam02108
1147129004043	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
1147129004044	FliG C-terminal domain; Region: FliG_C; pfam01706
1147129004045	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
1147129004046	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
1147129004047	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
1147129004048	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
1147129004049	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
1147129004050	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1147129004051	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
1147129004052	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129004053	active site
1147129004054	phosphorylation site [posttranslational modification]
1147129004055	intermolecular recognition site; other site
1147129004056	dimerization interface [polypeptide binding]; other site
1147129004057	CheB methylesterase; Region: CheB_methylest; pfam01339
1147129004058	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
1147129004059	putative CheA interaction surface; other site
1147129004060	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
1147129004061	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1147129004062	putative binding surface; other site
1147129004063	active site
1147129004064	P2 response regulator binding domain; Region: P2; pfam07194
1147129004065	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1147129004066	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147129004067	ATP binding site [chemical binding]; other site
1147129004068	Mg2+ binding site [ion binding]; other site
1147129004069	G-X-G motif; other site
1147129004070	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
1147129004071	Flagellar protein FliS; Region: FliS; cl00654
1147129004072	Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345
1147129004073	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
1147129004074	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
1147129004075	FlaG protein; Region: FlaG; pfam03646
1147129004076	flagellin; Provisional; Region: PRK12804
1147129004077	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1147129004078	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1147129004079	flagellin; Provisional; Region: PRK12804
1147129004080	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1147129004081	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1147129004082	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1147129004083	Interdomain contacts; other site
1147129004084	Cytokine receptor motif; other site
1147129004085	Helix-turn-helix domain; Region: HTH_38; pfam13936
1147129004086	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1147129004087	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1147129004088	active site
1147129004089	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1147129004090	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1147129004091	active site
1147129004092	catalytic tetrad [active]
1147129004093	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
1147129004094	Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232
1147129004095	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1147129004096	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
1147129004097	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1147129004098	PYR/PP interface [polypeptide binding]; other site
1147129004099	dimer interface [polypeptide binding]; other site
1147129004100	TPP binding site [chemical binding]; other site
1147129004101	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1147129004102	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1147129004103	TPP-binding site [chemical binding]; other site
1147129004104	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1147129004105	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1147129004106	NAD(P) binding site [chemical binding]; other site
1147129004107	active site
1147129004108	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
1147129004109	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
1147129004110	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
1147129004111	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1147129004112	PYR/PP interface [polypeptide binding]; other site
1147129004113	dimer interface [polypeptide binding]; other site
1147129004114	TPP binding site [chemical binding]; other site
1147129004115	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1147129004116	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1147129004117	TPP-binding site [chemical binding]; other site
1147129004118	dimer interface [polypeptide binding]; other site
1147129004119	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
1147129004120	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1147129004121	NAD(P) binding site [chemical binding]; other site
1147129004122	active site
1147129004123	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1147129004124	extended (e) SDRs; Region: SDR_e; cd08946
1147129004125	NAD(P) binding site [chemical binding]; other site
1147129004126	active site
1147129004127	substrate binding site [chemical binding]; other site
1147129004128	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1147129004129	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
1147129004130	substrate binding site; other site
1147129004131	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
1147129004132	putative metal binding site; other site
1147129004133	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147129004134	TPR motif; other site
1147129004135	binding surface
1147129004136	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1147129004137	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
1147129004138	putative metal binding site; other site
1147129004139	Global regulator protein family; Region: CsrA; pfam02599
1147129004140	FliW protein; Region: FliW; pfam02623
1147129004141	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701
1147129004142	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1147129004143	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1147129004144	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739
1147129004145	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1147129004146	FlgN protein; Region: FlgN; pfam05130
1147129004147	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
1147129004148	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
1147129004149	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
1147129004150	flagellar motor protein MotB; Reviewed; Region: motB; PRK07734
1147129004151	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1147129004152	ligand binding site [chemical binding]; other site
1147129004153	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1147129004154	Peptidase family M28; Region: Peptidase_M28; pfam04389
1147129004155	metal binding site [ion binding]; metal-binding site
1147129004156	Protein of unknown function (DUF327); Region: DUF327; pfam03885
1147129004157	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1147129004158	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1147129004159	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
1147129004160	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1147129004161	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1147129004162	NAD binding site [chemical binding]; other site
1147129004163	substrate binding site [chemical binding]; other site
1147129004164	homodimer interface [polypeptide binding]; other site
1147129004165	active site
1147129004166	G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189
1147129004167	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
1147129004168	substrate binding site; other site
1147129004169	metal-binding site
1147129004170	Oligomer interface; other site
1147129004171	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1147129004172	putative trimer interface [polypeptide binding]; other site
1147129004173	putative CoA binding site [chemical binding]; other site
1147129004174	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1147129004175	active site
1147129004176	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1147129004177	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
1147129004178	inhibitor-cofactor binding pocket; inhibition site
1147129004179	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147129004180	catalytic residue [active]
1147129004181	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
1147129004182	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
1147129004183	putative trimer interface [polypeptide binding]; other site
1147129004184	putative CoA binding site [chemical binding]; other site
1147129004185	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1147129004186	active site
1147129004187	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1147129004188	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
1147129004189	transmembrane helices; other site
1147129004190	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
1147129004191	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1147129004192	catalytic loop [active]
1147129004193	iron binding site [ion binding]; other site
1147129004194	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1147129004195	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
1147129004196	4Fe-4S binding domain; Region: Fer4; pfam00037
1147129004197	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
1147129004198	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
1147129004199	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
1147129004200	SLBB domain; Region: SLBB; pfam10531
1147129004201	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
1147129004202	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
1147129004203	dimer interface [polypeptide binding]; other site
1147129004204	[2Fe-2S] cluster binding site [ion binding]; other site
1147129004205	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
1147129004206	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
1147129004207	putative dimer interface [polypeptide binding]; other site
1147129004208	[2Fe-2S] cluster binding site [ion binding]; other site
1147129004209	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1147129004210	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
1147129004211	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
1147129004212	GMP synthase; Reviewed; Region: guaA; PRK00074
1147129004213	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1147129004214	AMP/PPi binding site [chemical binding]; other site
1147129004215	candidate oxyanion hole; other site
1147129004216	catalytic triad [active]
1147129004217	potential glutamine specificity residues [chemical binding]; other site
1147129004218	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1147129004219	ATP Binding subdomain [chemical binding]; other site
1147129004220	Ligand Binding sites [chemical binding]; other site
1147129004221	Dimerization subdomain; other site
1147129004222	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1147129004223	active site
1147129004224	YmaF family; Region: YmaF; pfam12788
1147129004225	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1147129004226	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1147129004227	ring oligomerisation interface [polypeptide binding]; other site
1147129004228	ATP/Mg binding site [chemical binding]; other site
1147129004229	stacking interactions; other site
1147129004230	hinge regions; other site
1147129004231	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1147129004232	oligomerisation interface [polypeptide binding]; other site
1147129004233	mobile loop; other site
1147129004234	roof hairpin; other site
1147129004235	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
1147129004236	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1147129004237	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1147129004238	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1147129004239	GTP binding site; other site
1147129004240	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
1147129004241	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1147129004242	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1147129004243	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1147129004244	Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524
1147129004245	active site residue [active]
1147129004246	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436
1147129004247	CPxP  motif; other site
1147129004248	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
1147129004249	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1147129004250	dimerization interface [polypeptide binding]; other site
1147129004251	putative DNA binding site [nucleotide binding]; other site
1147129004252	putative Zn2+ binding site [ion binding]; other site
1147129004253	EDD domain protein, DegV family; Region: DegV; TIGR00762
1147129004254	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1147129004255	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1147129004256	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1147129004257	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1147129004258	LabA_like proteins; Region: LabA_like; cd06167
1147129004259	putative metal binding site [ion binding]; other site
1147129004260	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1147129004261	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
1147129004262	catalytic loop [active]
1147129004263	iron binding site [ion binding]; other site
1147129004264	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1147129004265	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
1147129004266	[4Fe-4S] binding site [ion binding]; other site
1147129004267	molybdopterin cofactor binding site; other site
1147129004268	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
1147129004269	molybdopterin cofactor binding site; other site
1147129004270	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
1147129004271	dimer interface [polypeptide binding]; other site
1147129004272	[2Fe-2S] cluster binding site [ion binding]; other site
1147129004273	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
1147129004274	SLBB domain; Region: SLBB; pfam10531
1147129004275	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
1147129004276	4Fe-4S binding domain; Region: Fer4; pfam00037
1147129004277	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1147129004278	4Fe-4S binding domain; Region: Fer4; pfam00037
1147129004279	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
1147129004280	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
1147129004281	putative dimer interface [polypeptide binding]; other site
1147129004282	[2Fe-2S] cluster binding site [ion binding]; other site
1147129004283	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1147129004284	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
1147129004285	UGMP family protein; Validated; Region: PRK09604
1147129004286	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1147129004287	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
1147129004288	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1147129004289	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147129004290	Coenzyme A binding pocket [chemical binding]; other site
1147129004291	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1147129004292	Glycoprotease family; Region: Peptidase_M22; pfam00814
1147129004293	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1147129004294	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
1147129004295	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
1147129004296	active site
1147129004297	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1147129004298	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1147129004299	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1147129004300	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1147129004301	RNA binding site [nucleotide binding]; other site
1147129004302	PemK-like protein; Region: PemK; pfam02452
1147129004303	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
1147129004304	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1147129004305	catalytic triad [active]
1147129004306	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
1147129004307	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1147129004308	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
1147129004309	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1147129004310	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1147129004311	trimer interface [polypeptide binding]; other site
1147129004312	putative metal binding site [ion binding]; other site
1147129004313	MOSC domain; Region: MOSC; pfam03473
1147129004314	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
1147129004315	Walker A motif; other site
1147129004316	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1147129004317	MPT binding site; other site
1147129004318	trimer interface [polypeptide binding]; other site
1147129004319	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1147129004320	trimer interface [polypeptide binding]; other site
1147129004321	dimer interface [polypeptide binding]; other site
1147129004322	putative active site [active]
1147129004323	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
1147129004324	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147129004325	FeS/SAM binding site; other site
1147129004326	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1147129004327	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
1147129004328	putative MPT binding site; other site
1147129004329	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1147129004330	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1147129004331	dimer interface [polypeptide binding]; other site
1147129004332	putative functional site; other site
1147129004333	putative MPT binding site; other site
1147129004334	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
1147129004335	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
1147129004336	CoA binding domain; Region: CoA_binding; pfam02629
1147129004337	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
1147129004338	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
1147129004339	putative dimer interface [polypeptide binding]; other site
1147129004340	[2Fe-2S] cluster binding site [ion binding]; other site
1147129004341	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
1147129004342	SLBB domain; Region: SLBB; pfam10531
1147129004343	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
1147129004344	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
1147129004345	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1147129004346	catalytic loop [active]
1147129004347	iron binding site [ion binding]; other site
1147129004348	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1147129004349	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
1147129004350	4Fe-4S binding domain; Region: Fer4; pfam00037
1147129004351	4Fe-4S binding domain; Region: Fer4; pfam00037
1147129004352	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
1147129004353	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
1147129004354	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
1147129004355	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
1147129004356	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
1147129004357	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
1147129004358	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
1147129004359	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1147129004360	Zn2+ binding site [ion binding]; other site
1147129004361	Mg2+ binding site [ion binding]; other site
1147129004362	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1147129004363	dimerization interface [polypeptide binding]; other site
1147129004364	putative DNA binding site [nucleotide binding]; other site
1147129004365	putative Zn2+ binding site [ion binding]; other site
1147129004366	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
1147129004367	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1147129004368	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
1147129004369	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1147129004370	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1147129004371	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1147129004372	active site
1147129004373	dimer interface [polypeptide binding]; other site
1147129004374	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1147129004375	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1147129004376	active site
1147129004377	FMN binding site [chemical binding]; other site
1147129004378	substrate binding site [chemical binding]; other site
1147129004379	3Fe-4S cluster binding site [ion binding]; other site
1147129004380	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1147129004381	domain interface; other site
1147129004382	glutamate dehydrogenase; Provisional; Region: PRK09414
1147129004383	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1147129004384	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
1147129004385	NAD(P) binding site [chemical binding]; other site
1147129004386	alanine racemase; Reviewed; Region: alr; PRK00053
1147129004387	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1147129004388	active site
1147129004389	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1147129004390	dimer interface [polypeptide binding]; other site
1147129004391	substrate binding site [chemical binding]; other site
1147129004392	catalytic residues [active]
1147129004393	putative carbohydrate kinase; Provisional; Region: PRK10565
1147129004394	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
1147129004395	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1147129004396	putative substrate binding site [chemical binding]; other site
1147129004397	putative ATP binding site [chemical binding]; other site
1147129004398	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1147129004399	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
1147129004400	Histidine kinase; Region: His_kinase; pfam06580
1147129004401	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147129004402	ATP binding site [chemical binding]; other site
1147129004403	Mg2+ binding site [ion binding]; other site
1147129004404	G-X-G motif; other site
1147129004405	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1147129004406	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147129004407	DNA-binding site [nucleotide binding]; DNA binding site
1147129004408	TrkA-C domain; Region: TrkA_C; pfam02080
1147129004409	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
1147129004410	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147129004411	FeS/SAM binding site; other site
1147129004412	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
1147129004413	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
1147129004414	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1147129004415	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1147129004416	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1147129004417	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1147129004418	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
1147129004419	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147129004420	FeS/SAM binding site; other site
1147129004421	hypothetical protein; Provisional; Region: PRK03881
1147129004422	The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951
1147129004423	AMMECR1; Region: AMMECR1; cl00911
1147129004424	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
1147129004425	reductive dehalogenase; Region: RDH; TIGR02486
1147129004426	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1147129004427	FMN-binding domain; Region: FMN_bind; pfam04205
1147129004428	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1147129004429	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1147129004430	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
1147129004431	reductive dehalogenase; Region: RDH; TIGR02486
1147129004432	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1147129004433	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
1147129004434	ligand binding site [chemical binding]; other site
1147129004435	flexible hinge region; other site
1147129004436	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1147129004437	non-specific DNA interactions [nucleotide binding]; other site
1147129004438	DNA binding site [nucleotide binding]
1147129004439	sequence specific DNA binding site [nucleotide binding]; other site
1147129004440	putative cAMP binding site [chemical binding]; other site
1147129004441	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1147129004442	Transposase domain (DUF772); Region: DUF772; pfam05598
1147129004443	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
1147129004444	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
1147129004445	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1147129004446	hypothetical protein; Provisional; Region: PRK04164
1147129004447	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1147129004448	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
1147129004449	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
1147129004450	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
1147129004451	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
1147129004452	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
1147129004453	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
1147129004454	spore photoproduct lyase; Region: photo_TT_lyase; cl15393
1147129004455	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
1147129004456	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
1147129004457	active site
1147129004458	catalytic triad [active]
1147129004459	oxyanion hole [active]
1147129004460	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
1147129004461	putative active site [active]
1147129004462	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1147129004463	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1147129004464	Protein of unknown function (DUF3795); Region: DUF3795; pfam12675
1147129004465	Uncharacterized conserved protein [Function unknown]; Region: COG5646
1147129004466	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
1147129004467	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1147129004468	Zn2+ binding site [ion binding]; other site
1147129004469	Mg2+ binding site [ion binding]; other site
1147129004470	CoA binding domain; Region: CoA_binding_2; pfam13380
1147129004471	Integrase core domain; Region: rve_3; pfam13683
1147129004472	HTH-like domain; Region: HTH_21; pfam13276
1147129004473	Integrase core domain; Region: rve; pfam00665
1147129004474	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1147129004475	Transposase; Region: HTH_Tnp_1; cl17663
1147129004476	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1147129004477	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
1147129004478	DNA binding residues [nucleotide binding]
1147129004479	dimer interface [polypeptide binding]; other site
1147129004480	Transposase domain (DUF772); Region: DUF772; pfam05598
1147129004481	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1147129004482	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1147129004483	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1147129004484	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1147129004485	putative active site [active]
1147129004486	putative NTP binding site [chemical binding]; other site
1147129004487	putative nucleic acid binding site [nucleotide binding]; other site
1147129004488	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
1147129004489	Divergent AAA domain; Region: AAA_4; pfam04326
1147129004490	Domain of unknown function (DUF4362); Region: DUF4362; pfam14275
1147129004491	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1147129004492	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1147129004493	putative active site [active]
1147129004494	putative NTP binding site [chemical binding]; other site
1147129004495	putative nucleic acid binding site [nucleotide binding]; other site
1147129004496	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
1147129004497	SprT-like family; Region: SprT-like; pfam10263
1147129004498	SprT homologues; Region: SprT; cl01182
1147129004499	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1147129004500	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1147129004501	Protein of unknown function (DUF3102); Region: DUF3102; pfam11300
1147129004502	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
1147129004503	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147129004504	FeS/SAM binding site; other site
1147129004505	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
1147129004506	ATP cone domain; Region: ATP-cone; pfam03477
1147129004507	Class III ribonucleotide reductase; Region: RNR_III; cd01675
1147129004508	effector binding site; other site
1147129004509	active site
1147129004510	Zn binding site [ion binding]; other site
1147129004511	glycine loop; other site
1147129004512	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1147129004513	ATP cone domain; Region: ATP-cone; pfam03477
1147129004514	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1147129004515	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
1147129004516	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
1147129004517	substrate binding pocket [chemical binding]; other site
1147129004518	dimer interface [polypeptide binding]; other site
1147129004519	inhibitor binding site; inhibition site
1147129004520	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
1147129004521	B12 binding site [chemical binding]; other site
1147129004522	cobalt ligand [ion binding]; other site
1147129004523	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
1147129004524	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1147129004525	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129004526	active site
1147129004527	phosphorylation site [posttranslational modification]
1147129004528	intermolecular recognition site; other site
1147129004529	dimerization interface [polypeptide binding]; other site
1147129004530	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1147129004531	DNA binding site [nucleotide binding]
1147129004532	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1147129004533	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1147129004534	dimerization interface [polypeptide binding]; other site
1147129004535	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1147129004536	dimer interface [polypeptide binding]; other site
1147129004537	phosphorylation site [posttranslational modification]
1147129004538	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147129004539	ATP binding site [chemical binding]; other site
1147129004540	Mg2+ binding site [ion binding]; other site
1147129004541	G-X-G motif; other site
1147129004542	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
1147129004543	heat shock protein 90; Provisional; Region: PRK05218
1147129004544	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147129004545	ATP binding site [chemical binding]; other site
1147129004546	Mg2+ binding site [ion binding]; other site
1147129004547	G-X-G motif; other site
1147129004548	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
1147129004549	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
1147129004550	FeoC like transcriptional regulator; Region: FeoC; cl17677
1147129004551	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
1147129004552	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
1147129004553	G1 box; other site
1147129004554	GTP/Mg2+ binding site [chemical binding]; other site
1147129004555	Switch I region; other site
1147129004556	G2 box; other site
1147129004557	G3 box; other site
1147129004558	Switch II region; other site
1147129004559	G4 box; other site
1147129004560	G5 box; other site
1147129004561	Nucleoside recognition; Region: Gate; pfam07670
1147129004562	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
1147129004563	Nucleoside recognition; Region: Gate; pfam07670
1147129004564	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
1147129004565	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
1147129004566	PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993
1147129004567	glutamate racemase; Provisional; Region: PRK00865
1147129004568	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
1147129004569	2-isopropylmalate synthase; Validated; Region: PRK00915
1147129004570	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1147129004571	active site
1147129004572	catalytic residues [active]
1147129004573	metal binding site [ion binding]; metal-binding site
1147129004574	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1147129004575	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1147129004576	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
1147129004577	catalytic residue [active]
1147129004578	putative FPP diphosphate  binding site; other site
1147129004579	putative FPP binding hydrophobic cleft; other site
1147129004580	dimer interface [polypeptide binding]; other site
1147129004581	putative IPP diphosphate binding site; other site
1147129004582	CHAP domain; Region: CHAP; pfam05257
1147129004583	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1147129004584	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1147129004585	G1 box; other site
1147129004586	putative GEF interaction site [polypeptide binding]; other site
1147129004587	GTP/Mg2+ binding site [chemical binding]; other site
1147129004588	Switch I region; other site
1147129004589	G2 box; other site
1147129004590	G3 box; other site
1147129004591	Switch II region; other site
1147129004592	G4 box; other site
1147129004593	G5 box; other site
1147129004594	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1147129004595	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1147129004596	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
1147129004597	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
1147129004598	GIY-YIG motif/motif A; other site
1147129004599	putative active site [active]
1147129004600	putative metal binding site [ion binding]; other site
1147129004601	Homoserine O-succinyltransferase; Region: HTS; pfam04204
1147129004602	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
1147129004603	proposed active site lysine [active]
1147129004604	conserved cys residue [active]
1147129004605	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
1147129004606	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
1147129004607	dimer interface [polypeptide binding]; other site
1147129004608	active site
1147129004609	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1147129004610	catalytic residues [active]
1147129004611	substrate binding site [chemical binding]; other site
1147129004612	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
1147129004613	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
1147129004614	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1147129004615	Ligand Binding Site [chemical binding]; other site
1147129004616	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
1147129004617	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1147129004618	homodimer interface [polypeptide binding]; other site
1147129004619	substrate-cofactor binding pocket; other site
1147129004620	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147129004621	catalytic residue [active]
1147129004622	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
1147129004623	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
1147129004624	active site
1147129004625	multimer interface [polypeptide binding]; other site
1147129004626	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1147129004627	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1147129004628	dimer interface [polypeptide binding]; other site
1147129004629	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147129004630	catalytic residue [active]
1147129004631	Transcriptional regulator; Region: Rrf2; cl17282
1147129004632	Rrf2 family protein; Region: rrf2_super; TIGR00738
1147129004633	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
1147129004634	serine O-acetyltransferase; Region: cysE; TIGR01172
1147129004635	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1147129004636	trimer interface [polypeptide binding]; other site
1147129004637	active site
1147129004638	substrate binding site [chemical binding]; other site
1147129004639	CoA binding site [chemical binding]; other site
1147129004640	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
1147129004641	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
1147129004642	Ligand Binding Site [chemical binding]; other site
1147129004643	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1147129004644	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1147129004645	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
1147129004646	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
1147129004647	putative ATP binding site [chemical binding]; other site
1147129004648	putative substrate interface [chemical binding]; other site
1147129004649	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1147129004650	metal-binding site [ion binding]
1147129004651	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1147129004652	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1147129004653	metal-binding site [ion binding]
1147129004654	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1147129004655	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1147129004656	metal-binding site [ion binding]
1147129004657	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1147129004658	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1147129004659	Uncharacterized family 2; belongs to a superfamily containing transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_2; cd10159
1147129004660	putative homodimer interface [polypeptide binding]; other site
1147129004661	putative homotetramer interface [polypeptide binding]; other site
1147129004662	putative allosteric switch controlling residues; other site
1147129004663	putative metal binding site [ion binding]; other site
1147129004664	putative homodimer-homodimer interface [polypeptide binding]; other site
1147129004665	benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260
1147129004666	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
1147129004667	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
1147129004668	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1147129004669	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1147129004670	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1147129004671	dimerization interface [polypeptide binding]; other site
1147129004672	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
1147129004673	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1147129004674	homodimer interface [polypeptide binding]; other site
1147129004675	substrate-cofactor binding pocket; other site
1147129004676	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147129004677	catalytic residue [active]
1147129004678	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1147129004679	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1147129004680	dimer interface [polypeptide binding]; other site
1147129004681	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147129004682	catalytic residue [active]
1147129004683	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1147129004684	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1147129004685	active site
1147129004686	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1147129004687	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1147129004688	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1147129004689	catalytic residue [active]
1147129004690	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
1147129004691	DsrE/DsrF-like family; Region: DrsE; pfam02635
1147129004692	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
1147129004693	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147129004694	Walker A motif; other site
1147129004695	ATP binding site [chemical binding]; other site
1147129004696	Walker B motif; other site
1147129004697	arginine finger; other site
1147129004698	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1147129004699	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1147129004700	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1147129004701	glutaminase active site [active]
1147129004702	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1147129004703	dimer interface [polypeptide binding]; other site
1147129004704	active site
1147129004705	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1147129004706	dimer interface [polypeptide binding]; other site
1147129004707	active site
1147129004708	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
1147129004709	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1147129004710	active site
1147129004711	substrate binding site [chemical binding]; other site
1147129004712	metal binding site [ion binding]; metal-binding site
1147129004713	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
1147129004714	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1147129004715	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
1147129004716	YbbR-like protein; Region: YbbR; pfam07949
1147129004717	YbbR-like protein; Region: YbbR; pfam07949
1147129004718	TIGR00159 family protein; Region: TIGR00159
1147129004719	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1147129004720	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
1147129004721	homodimer interface [polypeptide binding]; other site
1147129004722	metal binding site [ion binding]; metal-binding site
1147129004723	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1147129004724	Zn2+ binding site [ion binding]; other site
1147129004725	Mg2+ binding site [ion binding]; other site
1147129004726	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1147129004727	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1147129004728	Alcohol acetyltransferase; Region: AATase; pfam07247
1147129004729	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
1147129004730	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
1147129004731	G1 box; other site
1147129004732	GTP/Mg2+ binding site [chemical binding]; other site
1147129004733	Switch I region; other site
1147129004734	G2 box; other site
1147129004735	Switch II region; other site
1147129004736	G3 box; other site
1147129004737	G4 box; other site
1147129004738	G5 box; other site
1147129004739	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1147129004740	Aspartase; Region: Aspartase; cd01357
1147129004741	active sites [active]
1147129004742	tetramer interface [polypeptide binding]; other site
1147129004743	[FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956
1147129004744	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147129004745	FeS/SAM binding site; other site
1147129004746	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613
1147129004747	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147129004748	FeS/SAM binding site; other site
1147129004749	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
1147129004750	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
1147129004751	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147129004752	sequence-specific DNA binding site [nucleotide binding]; other site
1147129004753	salt bridge; other site
1147129004754	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147129004755	ATP binding site [chemical binding]; other site
1147129004756	Mg2+ binding site [ion binding]; other site
1147129004757	G-X-G motif; other site
1147129004758	Domain of unknown function (DUF4325); Region: DUF4325; pfam14213
1147129004759	Phage holin protein (Holin_LLH); Region: Holin_LLH; cl09890
1147129004760	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1147129004761	Peptidase family M23; Region: Peptidase_M23; pfam01551
1147129004762	Holin family; Region: Phage_holin_4; pfam05105
1147129004763	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
1147129004764	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
1147129004765	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1147129004766	Phage terminase large subunit; Region: Terminase_3; cl12054
1147129004767	Terminase-like family; Region: Terminase_6; pfam03237
1147129004768	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
1147129004769	DNA binding residues [nucleotide binding]
1147129004770	CHC2 zinc finger; Region: zf-CHC2; cl17510
1147129004771	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
1147129004772	active site
1147129004773	metal binding site [ion binding]; metal-binding site
1147129004774	interdomain interaction site; other site
1147129004775	AAA domain; Region: AAA_25; pfam13481
1147129004776	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1147129004777	Walker A motif; other site
1147129004778	ATP binding site [chemical binding]; other site
1147129004779	Walker B motif; other site
1147129004780	Bacteriophage replication protein O; Region: Phage_rep_O; cl04545
1147129004781	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1147129004782	Transposase; Region: HTH_Tnp_1; pfam01527
1147129004783	putative transposase OrfB; Reviewed; Region: PHA02517
1147129004784	HTH-like domain; Region: HTH_21; pfam13276
1147129004785	Integrase core domain; Region: rve; pfam00665
1147129004786	Integrase core domain; Region: rve_3; pfam13683
1147129004787	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1147129004788	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147129004789	non-specific DNA binding site [nucleotide binding]; other site
1147129004790	salt bridge; other site
1147129004791	sequence-specific DNA binding site [nucleotide binding]; other site
1147129004792	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1147129004793	Double zinc ribbon; Region: DZR; pfam12773
1147129004794	Fic family protein [Function unknown]; Region: COG3177
1147129004795	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
1147129004796	Fic/DOC family; Region: Fic; pfam02661
1147129004797	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1147129004798	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147129004799	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1147129004800	non-specific DNA binding site [nucleotide binding]; other site
1147129004801	salt bridge; other site
1147129004802	sequence-specific DNA binding site [nucleotide binding]; other site
1147129004803	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1147129004804	Int/Topo IB signature motif; other site
1147129004805	Protease prsW family; Region: PrsW-protease; pfam13367
1147129004806	Domain of unknown function (DUF378); Region: DUF378; pfam04070
1147129004807	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147129004808	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1147129004809	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1147129004810	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1147129004811	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1147129004812	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1147129004813	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1147129004814	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
1147129004815	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1147129004816	Uncharacterized conserved protein [Function unknown]; Region: COG5663
1147129004817	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1147129004818	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1147129004819	homodimer interface [polypeptide binding]; other site
1147129004820	NAD binding pocket [chemical binding]; other site
1147129004821	ATP binding pocket [chemical binding]; other site
1147129004822	Mg binding site [ion binding]; other site
1147129004823	active-site loop [active]
1147129004824	argininosuccinate lyase; Provisional; Region: PRK00855
1147129004825	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1147129004826	active sites [active]
1147129004827	tetramer interface [polypeptide binding]; other site
1147129004828	argininosuccinate synthase; Provisional; Region: PRK13820
1147129004829	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1147129004830	ANP binding site [chemical binding]; other site
1147129004831	Substrate Binding Site II [chemical binding]; other site
1147129004832	Substrate Binding Site I [chemical binding]; other site
1147129004833	ornithine carbamoyltransferase; Provisional; Region: PRK00779
1147129004834	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1147129004835	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1147129004836	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1147129004837	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
1147129004838	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
1147129004839	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
1147129004840	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
1147129004841	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
1147129004842	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
1147129004843	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
1147129004844	PspC domain; Region: PspC; pfam04024
1147129004845	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
1147129004846	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
1147129004847	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
1147129004848	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
1147129004849	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
1147129004850	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
1147129004851	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
1147129004852	putative substrate-binding site; other site
1147129004853	nickel binding site [ion binding]; other site
1147129004854	aspartate aminotransferase; Provisional; Region: PRK05764
1147129004855	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1147129004856	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147129004857	homodimer interface [polypeptide binding]; other site
1147129004858	catalytic residue [active]
1147129004859	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1147129004860	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1147129004861	trimerization site [polypeptide binding]; other site
1147129004862	active site
1147129004863	Bacterial Ig-like domain; Region: Big_5; pfam13205
1147129004864	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
1147129004865	MG2 domain; Region: A2M_N; pfam01835
1147129004866	MG2 domain; Region: A2M_N; pfam01835
1147129004867	Alpha-2-macroglobulin family; Region: A2M; pfam00207
1147129004868	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
1147129004869	putative ligand binding pocket/active site [active]
1147129004870	putative metal binding site [ion binding]; other site
1147129004871	acetylornithine aminotransferase; Provisional; Region: PRK02627
1147129004872	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1147129004873	inhibitor-cofactor binding pocket; inhibition site
1147129004874	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147129004875	catalytic residue [active]
1147129004876	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
1147129004877	feedback inhibition sensing region; other site
1147129004878	homohexameric interface [polypeptide binding]; other site
1147129004879	nucleotide binding site [chemical binding]; other site
1147129004880	N-acetyl-L-glutamate binding site [chemical binding]; other site
1147129004881	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1147129004882	heterotetramer interface [polypeptide binding]; other site
1147129004883	active site pocket [active]
1147129004884	cleavage site
1147129004885	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
1147129004886	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1147129004887	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1147129004888	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1147129004889	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1147129004890	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129004891	active site
1147129004892	phosphorylation site [posttranslational modification]
1147129004893	intermolecular recognition site; other site
1147129004894	dimerization interface [polypeptide binding]; other site
1147129004895	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1147129004896	DNA binding site [nucleotide binding]
1147129004897	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1147129004898	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1147129004899	dimerization interface [polypeptide binding]; other site
1147129004900	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1147129004901	dimer interface [polypeptide binding]; other site
1147129004902	phosphorylation site [posttranslational modification]
1147129004903	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147129004904	ATP binding site [chemical binding]; other site
1147129004905	Mg2+ binding site [ion binding]; other site
1147129004906	G-X-G motif; other site
1147129004907	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1147129004908	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1147129004909	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1147129004910	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
1147129004911	Walker A/P-loop; other site
1147129004912	ATP binding site [chemical binding]; other site
1147129004913	Q-loop/lid; other site
1147129004914	ABC transporter signature motif; other site
1147129004915	Walker B; other site
1147129004916	D-loop; other site
1147129004917	H-loop/switch region; other site
1147129004918	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1147129004919	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1147129004920	active site
1147129004921	metal binding site [ion binding]; metal-binding site
1147129004922	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1147129004923	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1147129004924	23S rRNA interface [nucleotide binding]; other site
1147129004925	L3 interface [polypeptide binding]; other site
1147129004926	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1147129004927	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1147129004928	dimerization interface 3.5A [polypeptide binding]; other site
1147129004929	active site
1147129004930	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1147129004931	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1147129004932	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1147129004933	alphaNTD - beta interaction site [polypeptide binding]; other site
1147129004934	alphaNTD homodimer interface [polypeptide binding]; other site
1147129004935	alphaNTD - beta' interaction site [polypeptide binding]; other site
1147129004936	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1147129004937	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1147129004938	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1147129004939	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1147129004940	RNA binding surface [nucleotide binding]; other site
1147129004941	30S ribosomal protein S11; Validated; Region: PRK05309
1147129004942	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1147129004943	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1147129004944	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1147129004945	rRNA binding site [nucleotide binding]; other site
1147129004946	predicted 30S ribosome binding site; other site
1147129004947	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1147129004948	active site
1147129004949	adenylate kinase; Reviewed; Region: adk; PRK00279
1147129004950	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1147129004951	AMP-binding site [chemical binding]; other site
1147129004952	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1147129004953	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1147129004954	SecY translocase; Region: SecY; pfam00344
1147129004955	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1147129004956	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1147129004957	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1147129004958	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1147129004959	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1147129004960	5S rRNA interface [nucleotide binding]; other site
1147129004961	L27 interface [polypeptide binding]; other site
1147129004962	23S rRNA interface [nucleotide binding]; other site
1147129004963	L5 interface [polypeptide binding]; other site
1147129004964	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1147129004965	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1147129004966	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1147129004967	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1147129004968	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
1147129004969	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1147129004970	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1147129004971	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1147129004972	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1147129004973	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1147129004974	RNA binding site [nucleotide binding]; other site
1147129004975	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1147129004976	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1147129004977	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1147129004978	putative translocon interaction site; other site
1147129004979	signal recognition particle (SRP54) interaction site; other site
1147129004980	L23 interface [polypeptide binding]; other site
1147129004981	trigger factor interaction site; other site
1147129004982	23S rRNA interface [nucleotide binding]; other site
1147129004983	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1147129004984	5S rRNA interface [nucleotide binding]; other site
1147129004985	23S rRNA interface [nucleotide binding]; other site
1147129004986	putative antibiotic binding site [chemical binding]; other site
1147129004987	L25 interface [polypeptide binding]; other site
1147129004988	L27 interface [polypeptide binding]; other site
1147129004989	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1147129004990	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1147129004991	G-X-X-G motif; other site
1147129004992	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1147129004993	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1147129004994	putative translocon binding site; other site
1147129004995	protein-rRNA interface [nucleotide binding]; other site
1147129004996	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1147129004997	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1147129004998	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1147129004999	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1147129005000	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1147129005001	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1147129005002	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1147129005003	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1147129005004	elongation factor Tu; Reviewed; Region: PRK00049
1147129005005	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1147129005006	G1 box; other site
1147129005007	GEF interaction site [polypeptide binding]; other site
1147129005008	GTP/Mg2+ binding site [chemical binding]; other site
1147129005009	Switch I region; other site
1147129005010	G2 box; other site
1147129005011	G3 box; other site
1147129005012	Switch II region; other site
1147129005013	G4 box; other site
1147129005014	G5 box; other site
1147129005015	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1147129005016	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1147129005017	Antibiotic Binding Site [chemical binding]; other site
1147129005018	elongation factor G; Reviewed; Region: PRK00007
1147129005019	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1147129005020	G1 box; other site
1147129005021	putative GEF interaction site [polypeptide binding]; other site
1147129005022	GTP/Mg2+ binding site [chemical binding]; other site
1147129005023	Switch I region; other site
1147129005024	G2 box; other site
1147129005025	G3 box; other site
1147129005026	Switch II region; other site
1147129005027	G4 box; other site
1147129005028	G5 box; other site
1147129005029	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1147129005030	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1147129005031	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1147129005032	30S ribosomal protein S7; Validated; Region: PRK05302
1147129005033	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1147129005034	S17 interaction site [polypeptide binding]; other site
1147129005035	S8 interaction site; other site
1147129005036	16S rRNA interaction site [nucleotide binding]; other site
1147129005037	streptomycin interaction site [chemical binding]; other site
1147129005038	23S rRNA interaction site [nucleotide binding]; other site
1147129005039	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1147129005040	putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602
1147129005041	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
1147129005042	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1147129005043	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1147129005044	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1147129005045	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1147129005046	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1147129005047	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
1147129005048	G-loop; other site
1147129005049	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
1147129005050	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1147129005051	DNA binding site [nucleotide binding]
1147129005052	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1147129005053	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1147129005054	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1147129005055	RPB12 interaction site [polypeptide binding]; other site
1147129005056	RPB1 interaction site [polypeptide binding]; other site
1147129005057	RPB10 interaction site [polypeptide binding]; other site
1147129005058	RPB11 interaction site [polypeptide binding]; other site
1147129005059	RPB3 interaction site [polypeptide binding]; other site
1147129005060	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1147129005061	peripheral dimer interface [polypeptide binding]; other site
1147129005062	core dimer interface [polypeptide binding]; other site
1147129005063	L10 interface [polypeptide binding]; other site
1147129005064	L11 interface [polypeptide binding]; other site
1147129005065	putative EF-Tu interaction site [polypeptide binding]; other site
1147129005066	putative EF-G interaction site [polypeptide binding]; other site
1147129005067	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1147129005068	23S rRNA interface [nucleotide binding]; other site
1147129005069	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1147129005070	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1147129005071	mRNA/rRNA interface [nucleotide binding]; other site
1147129005072	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1147129005073	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1147129005074	23S rRNA interface [nucleotide binding]; other site
1147129005075	L7/L12 interface [polypeptide binding]; other site
1147129005076	putative thiostrepton binding site; other site
1147129005077	L25 interface [polypeptide binding]; other site
1147129005078	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1147129005079	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1147129005080	putative homodimer interface [polypeptide binding]; other site
1147129005081	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1147129005082	heterodimer interface [polypeptide binding]; other site
1147129005083	homodimer interface [polypeptide binding]; other site
1147129005084	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
1147129005085	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
1147129005086	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
1147129005087	active site
1147129005088	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1147129005089	Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858
1147129005090	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147129005091	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147129005092	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
1147129005093	active site
1147129005094	small acid-soluble spore protein Tlp; Provisional; Region: PRK03830
1147129005095	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129005096	Response regulator receiver domain; Region: Response_reg; pfam00072
1147129005097	active site
1147129005098	phosphorylation site [posttranslational modification]
1147129005099	intermolecular recognition site; other site
1147129005100	dimerization interface [polypeptide binding]; other site
1147129005101	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
1147129005102	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
1147129005103	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
1147129005104	RNA polymerase factor sigma-70; Validated; Region: PRK08295
1147129005105	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1147129005106	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1147129005107	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1147129005108	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
1147129005109	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1147129005110	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1147129005111	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1147129005112	folate binding site [chemical binding]; other site
1147129005113	NADP+ binding site [chemical binding]; other site
1147129005114	Thymidylate synthase complementing protein; Region: Thy1; cl03630
1147129005115	Thymidylate synthase complementing protein; Region: Thy1; pfam02511
1147129005116	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
1147129005117	active site
1147129005118	metal binding site [ion binding]; metal-binding site
1147129005119	dimerization interface [polypeptide binding]; other site
1147129005120	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1147129005121	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1147129005122	active site
1147129005123	HIGH motif; other site
1147129005124	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1147129005125	KMSKS motif; other site
1147129005126	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1147129005127	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1147129005128	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1147129005129	HIGH motif; other site
1147129005130	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1147129005131	active site
1147129005132	KMSKS motif; other site
1147129005133	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
1147129005134	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1147129005135	substrate binding site; other site
1147129005136	dimer interface; other site
1147129005137	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1147129005138	homotrimer interaction site [polypeptide binding]; other site
1147129005139	zinc binding site [ion binding]; other site
1147129005140	CDP-binding sites; other site
1147129005141	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
1147129005142	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
1147129005143	putative active site [active]
1147129005144	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
1147129005145	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
1147129005146	DNA repair protein RadA; Provisional; Region: PRK11823
1147129005147	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1147129005148	Walker A motif; other site
1147129005149	ATP binding site [chemical binding]; other site
1147129005150	Walker B motif; other site
1147129005151	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1147129005152	Clp protease ATP binding subunit; Region: clpC; CHL00095
1147129005153	Clp amino terminal domain; Region: Clp_N; pfam02861
1147129005154	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147129005155	Walker A motif; other site
1147129005156	ATP binding site [chemical binding]; other site
1147129005157	Walker B motif; other site
1147129005158	arginine finger; other site
1147129005159	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147129005160	Walker A motif; other site
1147129005161	ATP binding site [chemical binding]; other site
1147129005162	Walker B motif; other site
1147129005163	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1147129005164	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
1147129005165	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
1147129005166	ADP binding site [chemical binding]; other site
1147129005167	phosphagen binding site; other site
1147129005168	substrate specificity loop; other site
1147129005169	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
1147129005170	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
1147129005171	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1147129005172	nudix motif; other site
1147129005173	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
1147129005174	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
1147129005175	catalytic residues [active]
1147129005176	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1147129005177	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147129005178	S-adenosylmethionine binding site [chemical binding]; other site
1147129005179	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
1147129005180	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
1147129005181	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
1147129005182	putative metal binding site; other site
1147129005183	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
1147129005184	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147129005185	binding surface
1147129005186	TPR motif; other site
1147129005187	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147129005188	binding surface
1147129005189	TPR motif; other site
1147129005190	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1147129005191	dinuclear metal binding motif [ion binding]; other site
1147129005192	Coat F domain; Region: Coat_F; pfam07875
1147129005193	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
1147129005194	dimanganese center [ion binding]; other site
1147129005195	Uncharacterized conserved protein [Function unknown]; Region: COG3339
1147129005196	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1147129005197	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1147129005198	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1147129005199	homotrimer interaction site [polypeptide binding]; other site
1147129005200	putative active site [active]
1147129005201	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1147129005202	homotrimer interaction site [polypeptide binding]; other site
1147129005203	putative active site [active]
1147129005204	Transposase [DNA replication, recombination, and repair]; Region: COG5421
1147129005205	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1147129005206	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1147129005207	active site
1147129005208	HIGH motif; other site
1147129005209	dimer interface [polypeptide binding]; other site
1147129005210	KMSKS motif; other site
1147129005211	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1147129005212	RNA binding surface [nucleotide binding]; other site
1147129005213	Transglycosylase; Region: Transgly; pfam00912
1147129005214	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1147129005215	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1147129005216	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
1147129005217	MutS domain III; Region: MutS_III; pfam05192
1147129005218	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
1147129005219	Walker A/P-loop; other site
1147129005220	ATP binding site [chemical binding]; other site
1147129005221	Q-loop/lid; other site
1147129005222	ABC transporter signature motif; other site
1147129005223	Walker B; other site
1147129005224	D-loop; other site
1147129005225	H-loop/switch region; other site
1147129005226	Smr domain; Region: Smr; pfam01713
1147129005227	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1147129005228	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1147129005229	Peptidase family U32; Region: Peptidase_U32; pfam01136
1147129005230	Collagenase; Region: DUF3656; pfam12392
1147129005231	Peptidase family U32; Region: Peptidase_U32; pfam01136
1147129005232	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
1147129005233	TIGR01777 family protein; Region: yfcH
1147129005234	putative NAD(P) binding site [chemical binding]; other site
1147129005235	putative active site [active]
1147129005236	Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596
1147129005237	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1147129005238	Yip1 domain; Region: Yip1; pfam04893
1147129005239	Protein of unknown function (DUF3102); Region: DUF3102; pfam11300
1147129005240	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129005241	active site
1147129005242	phosphorylation site [posttranslational modification]
1147129005243	intermolecular recognition site; other site
1147129005244	dimerization interface [polypeptide binding]; other site
1147129005245	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1147129005246	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147129005247	non-specific DNA binding site [nucleotide binding]; other site
1147129005248	salt bridge; other site
1147129005249	sequence-specific DNA binding site [nucleotide binding]; other site
1147129005250	YcxB-like protein; Region: YcxB; pfam14317
1147129005251	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1147129005252	TPR motif; other site
1147129005253	binding surface
1147129005254	SIR2-like domain; Region: SIR2_2; pfam13289
1147129005255	putative transposase OrfB; Reviewed; Region: PHA02517
1147129005256	HTH-like domain; Region: HTH_21; pfam13276
1147129005257	Integrase core domain; Region: rve; pfam00665
1147129005258	Integrase core domain; Region: rve_3; pfam13683
1147129005259	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1147129005260	Transposase; Region: HTH_Tnp_1; pfam01527
1147129005261	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1147129005262	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1147129005263	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1147129005264	reductive dehalogenase; Region: RDH; TIGR02486
1147129005265	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
1147129005266	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1147129005267	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1147129005268	reductive dehalogenase; Region: RDH; TIGR02486
1147129005269	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
1147129005270	Alphaherpesvirus glycoprotein E; Region: Herpes_gE; pfam02480
1147129005271	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
1147129005272	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
1147129005273	Cell division protein ZapA; Region: ZapA; pfam05164
1147129005274	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1147129005275	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1147129005276	putative tRNA-binding site [nucleotide binding]; other site
1147129005277	B3/4 domain; Region: B3_4; pfam03483
1147129005278	tRNA synthetase B5 domain; Region: B5; pfam03484
1147129005279	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1147129005280	dimer interface [polypeptide binding]; other site
1147129005281	motif 1; other site
1147129005282	motif 3; other site
1147129005283	motif 2; other site
1147129005284	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1147129005285	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1147129005286	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1147129005287	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1147129005288	dimer interface [polypeptide binding]; other site
1147129005289	motif 1; other site
1147129005290	active site
1147129005291	motif 2; other site
1147129005292	motif 3; other site
1147129005293	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1147129005294	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1147129005295	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1147129005296	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1147129005297	23S rRNA binding site [nucleotide binding]; other site
1147129005298	L21 binding site [polypeptide binding]; other site
1147129005299	L13 binding site [polypeptide binding]; other site
1147129005300	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1147129005301	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1147129005302	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1147129005303	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1147129005304	Winged helix-turn helix; Region: HTH_29; pfam13551
1147129005305	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1147129005306	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
1147129005307	ligand binding site [chemical binding]; other site
1147129005308	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
1147129005309	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
1147129005310	generic binding surface I; other site
1147129005311	generic binding surface II; other site
1147129005312	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
1147129005313	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1147129005314	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1147129005315	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1147129005316	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
1147129005317	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1147129005318	active site
1147129005319	dimer interface [polypeptide binding]; other site
1147129005320	motif 1; other site
1147129005321	motif 2; other site
1147129005322	motif 3; other site
1147129005323	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1147129005324	anticodon binding site; other site
1147129005325	YtxC-like family; Region: YtxC; cl08500
1147129005326	Uncharacterized membrane protein [Function unknown]; Region: COG3949
1147129005327	Spore germination protein; Region: Spore_permease; cl17796
1147129005328	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1147129005329	dimerization interface [polypeptide binding]; other site
1147129005330	putative DNA binding site [nucleotide binding]; other site
1147129005331	putative Zn2+ binding site [ion binding]; other site
1147129005332	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
1147129005333	PAS domain S-box; Region: sensory_box; TIGR00229
1147129005334	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1147129005335	putative active site [active]
1147129005336	heme pocket [chemical binding]; other site
1147129005337	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1147129005338	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1147129005339	metal binding site [ion binding]; metal-binding site
1147129005340	active site
1147129005341	I-site; other site
1147129005342	spermidine synthase; Provisional; Region: PRK00811
1147129005343	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147129005344	S-adenosylmethionine binding site [chemical binding]; other site
1147129005345	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
1147129005346	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1147129005347	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1147129005348	catalytic residue [active]
1147129005349	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1147129005350	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1147129005351	Coenzyme A binding pocket [chemical binding]; other site
1147129005352	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
1147129005353	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1147129005354	active site
1147129005355	catalytic residues [active]
1147129005356	metal binding site [ion binding]; metal-binding site
1147129005357	Iron only nitrogenase protein AnfO (AnfO_nitrog); Region: AnfO_nitrog; cl17112
1147129005358	Iron only nitrogenase protein AnfO (AnfO_nitrog); Region: AnfO_nitrog; cl17112
1147129005359	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1147129005360	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
1147129005361	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
1147129005362	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
1147129005363	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
1147129005364	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
1147129005365	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1147129005366	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
1147129005367	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
1147129005368	MoFe protein beta/alpha subunit interactions; other site
1147129005369	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
1147129005370	Beta subunit P cluster binding residues; other site
1147129005371	MoFe protein beta subunit/Fe protein contacts; other site
1147129005372	MoFe protein dimer/ dimer interactions; other site
1147129005373	Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
1147129005374	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
1147129005375	MoFe protein alpha/beta subunit interactions; other site
1147129005376	Alpha subunit P cluster binding residues; other site
1147129005377	FeMoco binding residues [chemical binding]; other site
1147129005378	MoFe protein alpha subunit/Fe protein contacts; other site
1147129005379	MoFe protein dimer/ dimer interactions; other site
1147129005380	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
1147129005381	nitrogenase iron protein; Region: nifH; TIGR01287
1147129005382	Nucleotide-binding sites [chemical binding]; other site
1147129005383	Walker A motif; other site
1147129005384	Switch I region of nucleotide binding site; other site
1147129005385	Fe4S4 binding sites [ion binding]; other site
1147129005386	Switch II region of nucleotide binding site; other site
1147129005387	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
1147129005388	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1147129005389	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
1147129005390	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1147129005391	Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096
1147129005392	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1147129005393	Family description; Region: VCBS; pfam13517
1147129005394	Family description; Region: VCBS; pfam13517
1147129005395	Family description; Region: VCBS; pfam13517
1147129005396	Tocopherol cyclase; Region: Tocopherol_cycl; cl14571
1147129005397	beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555
1147129005398	Protein of unknown function (DUF1638); Region: DUF1638; pfam07796
1147129005399	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1147129005400	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1147129005401	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
1147129005402	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
1147129005403	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1147129005404	B12 binding site [chemical binding]; other site
1147129005405	methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535
1147129005406	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
1147129005407	substrate binding pocket [chemical binding]; other site
1147129005408	dimer interface [polypeptide binding]; other site
1147129005409	inhibitor binding site; inhibition site
1147129005410	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1147129005411	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147129005412	DNA-binding site [nucleotide binding]; DNA binding site
1147129005413	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147129005414	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1147129005415	DNA-binding site [nucleotide binding]; DNA binding site
1147129005416	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1147129005417	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
1147129005418	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1147129005419	B12 binding site [chemical binding]; other site
1147129005420	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
1147129005421	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1147129005422	cofactor binding site; other site
1147129005423	hypothetical protein; Provisional; Region: PRK06153
1147129005424	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
1147129005425	ATP binding site [chemical binding]; other site
1147129005426	substrate interface [chemical binding]; other site
1147129005427	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
1147129005428	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
1147129005429	DXD motif; other site
1147129005430	peptidase T-like protein; Region: PepT-like; TIGR01883
1147129005431	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
1147129005432	metal binding site [ion binding]; metal-binding site
1147129005433	putative dimer interface [polypeptide binding]; other site
1147129005434	Uncharacterized conserved protein [Function unknown]; Region: COG4198
1147129005435	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
1147129005436	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
1147129005437	glycerate dehydrogenase; Provisional; Region: PRK06436
1147129005438	putative ligand binding site [chemical binding]; other site
1147129005439	putative NAD binding site [chemical binding]; other site
1147129005440	putative catalytic site [active]
1147129005441	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
1147129005442	L-serine binding site [chemical binding]; other site
1147129005443	ACT domain interface; other site
1147129005444	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
1147129005445	homodimer interface [polypeptide binding]; other site
1147129005446	substrate-cofactor binding pocket; other site
1147129005447	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147129005448	catalytic residue [active]
1147129005449	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1147129005450	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1147129005451	Winged helix-turn helix; Region: HTH_29; pfam13551
1147129005452	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
1147129005453	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
1147129005454	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
1147129005455	Walker A motif; other site
1147129005456	ATP binding site [chemical binding]; other site
1147129005457	Walker B motif; other site
1147129005458	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
1147129005459	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1147129005460	Walker A motif; other site
1147129005461	ATP binding site [chemical binding]; other site
1147129005462	Walker B motif; other site
1147129005463	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
1147129005464	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
1147129005465	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1147129005466	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1147129005467	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
1147129005468	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
1147129005469	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
1147129005470	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
1147129005471	Type II secretion system (T2SS), protein M; Region: T2SM; cl01222
1147129005472	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
1147129005473	Competence protein A; Region: Competence_A; pfam11104
1147129005474	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1147129005475	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
1147129005476	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1147129005477	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1147129005478	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1147129005479	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1147129005480	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1147129005481	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1147129005482	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1147129005483	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1147129005484	dihydrodipicolinate synthase; Region: dapA; TIGR00674
1147129005485	dimer interface [polypeptide binding]; other site
1147129005486	active site
1147129005487	catalytic residue [active]
1147129005488	aspartate kinase I; Reviewed; Region: PRK08210
1147129005489	AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of  the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260
1147129005490	putative catalytic residues [active]
1147129005491	putative nucleotide binding site [chemical binding]; other site
1147129005492	putative aspartate binding site [chemical binding]; other site
1147129005493	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914
1147129005494	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1147129005495	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1147129005496	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1147129005497	dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305
1147129005498	dipicolinate synthase subunit A; Reviewed; Region: PRK08306
1147129005499	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
1147129005500	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1147129005501	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1147129005502	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1147129005503	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
1147129005504	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
1147129005505	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147129005506	putative substrate translocation pore; other site
1147129005507	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1147129005508	trimer interface [polypeptide binding]; other site
1147129005509	active site
1147129005510	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1147129005511	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1147129005512	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1147129005513	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1147129005514	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1147129005515	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
1147129005516	Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950
1147129005517	NodB motif; other site
1147129005518	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1147129005519	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1147129005520	RNase E interface [polypeptide binding]; other site
1147129005521	trimer interface [polypeptide binding]; other site
1147129005522	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1147129005523	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1147129005524	RNase E interface [polypeptide binding]; other site
1147129005525	trimer interface [polypeptide binding]; other site
1147129005526	active site
1147129005527	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1147129005528	putative nucleic acid binding region [nucleotide binding]; other site
1147129005529	G-X-X-G motif; other site
1147129005530	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1147129005531	RNA binding site [nucleotide binding]; other site
1147129005532	domain interface; other site
1147129005533	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1147129005534	16S/18S rRNA binding site [nucleotide binding]; other site
1147129005535	S13e-L30e interaction site [polypeptide binding]; other site
1147129005536	25S rRNA binding site [nucleotide binding]; other site
1147129005537	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1147129005538	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1147129005539	active site
1147129005540	Riboflavin kinase; Region: Flavokinase; smart00904
1147129005541	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130
1147129005542	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1147129005543	RNA binding site [nucleotide binding]; other site
1147129005544	active site
1147129005545	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1147129005546	DHH family; Region: DHH; pfam01368
1147129005547	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1147129005548	translation initiation factor IF-2; Region: IF-2; TIGR00487
1147129005549	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1147129005550	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1147129005551	G1 box; other site
1147129005552	putative GEF interaction site [polypeptide binding]; other site
1147129005553	GTP/Mg2+ binding site [chemical binding]; other site
1147129005554	Switch I region; other site
1147129005555	G2 box; other site
1147129005556	G3 box; other site
1147129005557	Switch II region; other site
1147129005558	G4 box; other site
1147129005559	G5 box; other site
1147129005560	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1147129005561	Translation-initiation factor 2; Region: IF-2; pfam11987
1147129005562	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1147129005563	Ribosomal protein HS6-type (S12/L30/L7a) [Translation, ribosomal structure and biogenesis]; Region: RPL8A; COG1358
1147129005564	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
1147129005565	putative RNA binding cleft [nucleotide binding]; other site
1147129005566	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1147129005567	NusA N-terminal domain; Region: NusA_N; pfam08529
1147129005568	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1147129005569	RNA binding site [nucleotide binding]; other site
1147129005570	homodimer interface [polypeptide binding]; other site
1147129005571	NusA-like KH domain; Region: KH_5; pfam13184
1147129005572	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1147129005573	G-X-X-G motif; other site
1147129005574	Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576
1147129005575	Sm and related proteins; Region: Sm_like; cl00259
1147129005576	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1147129005577	putative oligomer interface [polypeptide binding]; other site
1147129005578	putative RNA binding site [nucleotide binding]; other site
1147129005579	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
1147129005580	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
1147129005581	generic binding surface II; other site
1147129005582	generic binding surface I; other site
1147129005583	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
1147129005584	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
1147129005585	active site
1147129005586	putative PHP Thumb interface [polypeptide binding]; other site
1147129005587	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
1147129005588	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1147129005589	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1147129005590	dimer interface [polypeptide binding]; other site
1147129005591	motif 1; other site
1147129005592	active site
1147129005593	motif 2; other site
1147129005594	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1147129005595	putative deacylase active site [active]
1147129005596	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1147129005597	active site
1147129005598	motif 3; other site
1147129005599	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1147129005600	anticodon binding site; other site
1147129005601	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1147129005602	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1147129005603	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1147129005604	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
1147129005605	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1147129005606	active site
1147129005607	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1147129005608	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1147129005609	putative substrate binding region [chemical binding]; other site
1147129005610	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1147129005611	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1147129005612	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1147129005613	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1147129005614	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
1147129005615	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1147129005616	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1147129005617	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1147129005618	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
1147129005619	catalytic residue [active]
1147129005620	putative FPP diphosphate  binding site; other site
1147129005621	putative FPP binding hydrophobic cleft; other site
1147129005622	dimer interface [polypeptide binding]; other site
1147129005623	putative IPP diphosphate binding site; other site
1147129005624	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1147129005625	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1147129005626	hinge region; other site
1147129005627	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1147129005628	putative nucleotide binding site [chemical binding]; other site
1147129005629	uridine monophosphate binding site [chemical binding]; other site
1147129005630	homohexameric interface [polypeptide binding]; other site
1147129005631	elongation factor Ts; Reviewed; Region: tsf; PRK12332
1147129005632	UBA/TS-N domain; Region: UBA; pfam00627
1147129005633	Elongation factor TS; Region: EF_TS; pfam00889
1147129005634	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1147129005635	rRNA interaction site [nucleotide binding]; other site
1147129005636	S8 interaction site; other site
1147129005637	putative laminin-1 binding site; other site
1147129005638	transcriptional repressor CodY; Validated; Region: PRK04158
1147129005639	CodY GAF-like domain; Region: CodY; pfam06018
1147129005640	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
1147129005641	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
1147129005642	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147129005643	Walker A motif; other site
1147129005644	ATP binding site [chemical binding]; other site
1147129005645	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
1147129005646	Walker B motif; other site
1147129005647	arginine finger; other site
1147129005648	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1147129005649	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1147129005650	active site
1147129005651	HslU subunit interaction site [polypeptide binding]; other site
1147129005652	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
1147129005653	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1147129005654	active site
1147129005655	DNA binding site [nucleotide binding]
1147129005656	Int/Topo IB signature motif; other site
1147129005657	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1147129005658	Glucose inhibited division protein A; Region: GIDA; pfam01134
1147129005659	DNA topoisomerase I; Validated; Region: PRK05582
1147129005660	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1147129005661	active site
1147129005662	interdomain interaction site; other site
1147129005663	putative metal-binding site [ion binding]; other site
1147129005664	nucleotide binding site [chemical binding]; other site
1147129005665	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1147129005666	domain I; other site
1147129005667	DNA binding groove [nucleotide binding]
1147129005668	phosphate binding site [ion binding]; other site
1147129005669	domain II; other site
1147129005670	domain III; other site
1147129005671	nucleotide binding site [chemical binding]; other site
1147129005672	catalytic site [active]
1147129005673	domain IV; other site
1147129005674	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1147129005675	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1147129005676	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1147129005677	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1147129005678	DNA protecting protein DprA; Region: dprA; TIGR00732
1147129005679	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
1147129005680	Protein of unknown function (DUF1659); Region: DUF1659; pfam07872
1147129005681	Protein of unknown function (DUF3102); Region: DUF3102; pfam11300
1147129005682	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
1147129005683	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147129005684	non-specific DNA binding site [nucleotide binding]; other site
1147129005685	salt bridge; other site
1147129005686	sequence-specific DNA binding site [nucleotide binding]; other site
1147129005687	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
1147129005688	Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648
1147129005689	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1147129005690	AP (apurinic/apyrimidinic) site pocket; other site
1147129005691	DNA interaction; other site
1147129005692	Metal-binding active site; metal-binding site
1147129005693	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
1147129005694	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1147129005695	ligand binding site [chemical binding]; other site
1147129005696	NAD binding site [chemical binding]; other site
1147129005697	dimerization interface [polypeptide binding]; other site
1147129005698	catalytic site [active]
1147129005699	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
1147129005700	putative L-serine binding site [chemical binding]; other site
1147129005701	NlpC/P60 family; Region: NLPC_P60; pfam00877
1147129005702	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1147129005703	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1147129005704	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1147129005705	FMN binding site [chemical binding]; other site
1147129005706	substrate binding site [chemical binding]; other site
1147129005707	putative catalytic residue [active]
1147129005708	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
1147129005709	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
1147129005710	putative DNA binding site [nucleotide binding]; other site
1147129005711	putative homodimer interface [polypeptide binding]; other site
1147129005712	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
1147129005713	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
1147129005714	active site
1147129005715	DNA binding site [nucleotide binding]
1147129005716	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
1147129005717	DNA binding site [nucleotide binding]
1147129005718	LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861
1147129005719	nucleotide binding site [chemical binding]; other site
1147129005720	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
1147129005721	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1147129005722	G1 box; other site
1147129005723	putative GEF interaction site [polypeptide binding]; other site
1147129005724	GTP/Mg2+ binding site [chemical binding]; other site
1147129005725	Switch I region; other site
1147129005726	G2 box; other site
1147129005727	G3 box; other site
1147129005728	Switch II region; other site
1147129005729	G4 box; other site
1147129005730	G5 box; other site
1147129005731	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1147129005732	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1147129005733	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1147129005734	metal-binding site [ion binding]
1147129005735	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1147129005736	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1147129005737	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1147129005738	dimerization interface [polypeptide binding]; other site
1147129005739	putative DNA binding site [nucleotide binding]; other site
1147129005740	putative Zn2+ binding site [ion binding]; other site
1147129005741	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
1147129005742	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
1147129005743	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
1147129005744	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
1147129005745	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
1147129005746	hypothetical protein; Reviewed; Region: PRK12497
1147129005747	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053
1147129005748	L-aspartate oxidase; Provisional; Region: PRK06175
1147129005749	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1147129005750	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1147129005751	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1147129005752	ligand binding site [chemical binding]; other site
1147129005753	flexible hinge region; other site
1147129005754	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1147129005755	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
1147129005756	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1147129005757	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147129005758	Walker A motif; other site
1147129005759	ATP binding site [chemical binding]; other site
1147129005760	Walker B motif; other site
1147129005761	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1147129005762	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147129005763	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1147129005764	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1147129005765	RNA/DNA hybrid binding site [nucleotide binding]; other site
1147129005766	active site
1147129005767	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
1147129005768	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
1147129005769	GTP/Mg2+ binding site [chemical binding]; other site
1147129005770	G4 box; other site
1147129005771	G5 box; other site
1147129005772	G1 box; other site
1147129005773	Switch I region; other site
1147129005774	G2 box; other site
1147129005775	G3 box; other site
1147129005776	Switch II region; other site
1147129005777	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1147129005778	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1147129005779	SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936
1147129005780	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1147129005781	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1147129005782	RimM N-terminal domain; Region: RimM; pfam01782
1147129005783	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
1147129005784	hypothetical protein; Provisional; Region: PRK00468
1147129005785	G-X-X-G motif; other site
1147129005786	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
1147129005787	signal recognition particle protein; Provisional; Region: PRK10867
1147129005788	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1147129005789	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1147129005790	P loop; other site
1147129005791	GTP binding site [chemical binding]; other site
1147129005792	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1147129005793	putative DNA-binding protein; Validated; Region: PRK00118
1147129005794	Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729
1147129005795	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1147129005796	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1147129005797	metal binding site [ion binding]; metal-binding site
1147129005798	active site
1147129005799	I-site; other site
1147129005800	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1147129005801	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
1147129005802	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
1147129005803	active site
1147129005804	putative substrate binding pocket [chemical binding]; other site
1147129005805	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182
1147129005806	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
1147129005807	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
1147129005808	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1147129005809	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1147129005810	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1147129005811	P loop; other site
1147129005812	GTP binding site [chemical binding]; other site
1147129005813	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1147129005814	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1147129005815	Walker A/P-loop; other site
1147129005816	ATP binding site [chemical binding]; other site
1147129005817	Q-loop/lid; other site
1147129005818	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
1147129005819	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1147129005820	ABC transporter signature motif; other site
1147129005821	Walker B; other site
1147129005822	D-loop; other site
1147129005823	H-loop/switch region; other site
1147129005824	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
1147129005825	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1147129005826	dimerization interface [polypeptide binding]; other site
1147129005827	active site
1147129005828	metal binding site [ion binding]; metal-binding site
1147129005829	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1147129005830	dsRNA binding site [nucleotide binding]; other site
1147129005831	acyl carrier protein; Provisional; Region: acpP; PRK00982
1147129005832	putative phosphate acyltransferase; Provisional; Region: PRK05331
1147129005833	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
1147129005834	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
1147129005835	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1147129005836	propionate/acetate kinase; Provisional; Region: PRK12379
1147129005837	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
1147129005838	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
1147129005839	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
1147129005840	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147129005841	S-adenosylmethionine binding site [chemical binding]; other site
1147129005842	germination protease; Provisional; Region: PRK12362
1147129005843	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1147129005844	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1147129005845	generic binding surface II; other site
1147129005846	ssDNA binding site; other site
1147129005847	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1147129005848	ATP binding site [chemical binding]; other site
1147129005849	putative Mg++ binding site [ion binding]; other site
1147129005850	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1147129005851	nucleotide binding region [chemical binding]; other site
1147129005852	ATP-binding site [chemical binding]; other site
1147129005853	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
1147129005854	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1147129005855	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
1147129005856	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1147129005857	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
1147129005858	putative L-serine binding site [chemical binding]; other site
1147129005859	Transposase [DNA replication, recombination, and repair]; Region: COG5421
1147129005860	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
1147129005861	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
1147129005862	DAK2 domain; Region: Dak2; pfam02734
1147129005863	Asp23 family; Region: Asp23; pfam03780
1147129005864	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1147129005865	Thiamine pyrophosphokinase; Region: TPK; cd07995
1147129005866	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
1147129005867	active site
1147129005868	dimerization interface [polypeptide binding]; other site
1147129005869	thiamine binding site [chemical binding]; other site
1147129005870	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1147129005871	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1147129005872	substrate binding site [chemical binding]; other site
1147129005873	hexamer interface [polypeptide binding]; other site
1147129005874	metal binding site [ion binding]; metal-binding site
1147129005875	GTPase RsgA; Reviewed; Region: PRK00098
1147129005876	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
1147129005877	RNA binding site [nucleotide binding]; other site
1147129005878	homodimer interface [polypeptide binding]; other site
1147129005879	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1147129005880	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1147129005881	GTP/Mg2+ binding site [chemical binding]; other site
1147129005882	G4 box; other site
1147129005883	G5 box; other site
1147129005884	G1 box; other site
1147129005885	Switch I region; other site
1147129005886	G2 box; other site
1147129005887	G3 box; other site
1147129005888	Switch II region; other site
1147129005889	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1147129005890	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1147129005891	active site
1147129005892	ATP binding site [chemical binding]; other site
1147129005893	substrate binding site [chemical binding]; other site
1147129005894	activation loop (A-loop); other site
1147129005895	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1147129005896	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1147129005897	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1147129005898	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1147129005899	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
1147129005900	Protein phosphatase 2C; Region: PP2C; pfam00481
1147129005901	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1147129005902	active site
1147129005903	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1147129005904	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1147129005905	phosphopeptide binding site; other site
1147129005906	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
1147129005907	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1147129005908	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1147129005909	phosphopeptide binding site; other site
1147129005910	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
1147129005911	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147129005912	FeS/SAM binding site; other site
1147129005913	16S rRNA methyltransferase B; Provisional; Region: PRK14902
1147129005914	NusB family; Region: NusB; pfam01029
1147129005915	putative RNA binding site [nucleotide binding]; other site
1147129005916	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147129005917	S-adenosylmethionine binding site [chemical binding]; other site
1147129005918	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
1147129005919	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1147129005920	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1147129005921	putative active site [active]
1147129005922	substrate binding site [chemical binding]; other site
1147129005923	putative cosubstrate binding site; other site
1147129005924	catalytic site [active]
1147129005925	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1147129005926	substrate binding site [chemical binding]; other site
1147129005927	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1147129005928	active site
1147129005929	catalytic residues [active]
1147129005930	metal binding site [ion binding]; metal-binding site
1147129005931	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
1147129005932	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1147129005933	ATP binding site [chemical binding]; other site
1147129005934	putative Mg++ binding site [ion binding]; other site
1147129005935	nucleotide binding region [chemical binding]; other site
1147129005936	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
1147129005937	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1147129005938	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147129005939	S-adenosylmethionine binding site [chemical binding]; other site
1147129005940	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
1147129005941	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1147129005942	FAD binding site [chemical binding]; other site
1147129005943	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1147129005944	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1147129005945	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1147129005946	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1147129005947	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1147129005948	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1147129005949	purine monophosphate binding site [chemical binding]; other site
1147129005950	dimer interface [polypeptide binding]; other site
1147129005951	putative catalytic residues [active]
1147129005952	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1147129005953	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1147129005954	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1147129005955	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1147129005956	active site
1147129005957	substrate binding site [chemical binding]; other site
1147129005958	cosubstrate binding site; other site
1147129005959	catalytic site [active]
1147129005960	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1147129005961	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1147129005962	dimerization interface [polypeptide binding]; other site
1147129005963	putative ATP binding site [chemical binding]; other site
1147129005964	amidophosphoribosyltransferase; Provisional; Region: PRK05793
1147129005965	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1147129005966	active site
1147129005967	tetramer interface [polypeptide binding]; other site
1147129005968	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1147129005969	active site
1147129005970	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
1147129005971	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
1147129005972	ATP binding site [chemical binding]; other site
1147129005973	active site
1147129005974	substrate binding site [chemical binding]; other site
1147129005975	adenylosuccinate lyase; Provisional; Region: PRK07492
1147129005976	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
1147129005977	tetramer interface [polypeptide binding]; other site
1147129005978	active site
1147129005979	AIR carboxylase; Region: AIRC; pfam00731
1147129005980	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
1147129005981	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1147129005982	Zn2+ binding site [ion binding]; other site
1147129005983	Mg2+ binding site [ion binding]; other site
1147129005984	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1147129005985	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1147129005986	Walker A/P-loop; other site
1147129005987	ATP binding site [chemical binding]; other site
1147129005988	Q-loop/lid; other site
1147129005989	ABC transporter signature motif; other site
1147129005990	Walker B; other site
1147129005991	D-loop; other site
1147129005992	H-loop/switch region; other site
1147129005993	Predicted transcriptional regulators [Transcription]; Region: COG1725
1147129005994	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147129005995	DNA-binding site [nucleotide binding]; DNA binding site
1147129005996	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1147129005997	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
1147129005998	ligand binding site [chemical binding]; other site
1147129005999	flexible hinge region; other site
1147129006000	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1147129006001	putative switch regulator; other site
1147129006002	non-specific DNA interactions [nucleotide binding]; other site
1147129006003	DNA binding site [nucleotide binding]
1147129006004	sequence specific DNA binding site [nucleotide binding]; other site
1147129006005	putative cAMP binding site [chemical binding]; other site
1147129006006	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1147129006007	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1147129006008	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1147129006009	reductive dehalogenase; Region: RDH; TIGR02486
1147129006010	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
1147129006011	dipeptidase PepV; Reviewed; Region: PRK07318
1147129006012	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
1147129006013	active site
1147129006014	metal binding site [ion binding]; metal-binding site
1147129006015	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1147129006016	Ferredoxin [Energy production and conversion]; Region: COG1146
1147129006017	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1147129006018	active site
1147129006019	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1147129006020	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1147129006021	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1147129006022	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1147129006023	catalytic residue [active]
1147129006024	Cupin domain; Region: Cupin_2; pfam07883
1147129006025	Chorismate mutase [Amino acid transport and metabolism]; Region: PheA; COG1605
1147129006026	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
1147129006027	Prephenate dehydratase; Region: PDT; pfam00800
1147129006028	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1147129006029	putative L-Phe binding site [chemical binding]; other site
1147129006030	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1147129006031	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1147129006032	Tetramer interface [polypeptide binding]; other site
1147129006033	active site
1147129006034	FMN-binding site [chemical binding]; other site
1147129006035	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1147129006036	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1147129006037	hinge; other site
1147129006038	active site
1147129006039	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
1147129006040	prephenate dehydrogenase; Validated; Region: PRK08507
1147129006041	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
1147129006042	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
1147129006043	Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191
1147129006044	FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663
1147129006045	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1147129006046	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1147129006047	ABC-ATPase subunit  interface; other site
1147129006048	dimer interface [polypeptide binding]; other site
1147129006049	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1147129006050	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1147129006051	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1147129006052	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1147129006053	intersubunit interface [polypeptide binding]; other site
1147129006054	ferric uptake regulator; Provisional; Region: fur; PRK09462
1147129006055	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1147129006056	metal binding site 2 [ion binding]; metal-binding site
1147129006057	putative DNA binding helix; other site
1147129006058	metal binding site 1 [ion binding]; metal-binding site
1147129006059	dimer interface [polypeptide binding]; other site
1147129006060	structural Zn2+ binding site [ion binding]; other site
1147129006061	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
1147129006062	Family description; Region: UvrD_C_2; pfam13538
1147129006063	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1147129006064	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
1147129006065	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1147129006066	Nucleoside Triphosphate Pyrophosphohydrolase EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u6; cd11543
1147129006067	2-ketoisovalerate ferredoxin oxidoreductase subunit delta; Reviewed; Region: vorD; PRK09623
1147129006068	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
1147129006069	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
1147129006070	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
1147129006071	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
1147129006072	NADH dehydrogenase; Region: NADHdh; cl00469
1147129006073	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1147129006074	putative oxidoreductase; Provisional; Region: PRK12831
1147129006075	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1147129006076	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1147129006077	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
1147129006078	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
1147129006079	FAD binding pocket [chemical binding]; other site
1147129006080	FAD binding motif [chemical binding]; other site
1147129006081	phosphate binding motif [ion binding]; other site
1147129006082	beta-alpha-beta structure motif; other site
1147129006083	NAD binding pocket [chemical binding]; other site
1147129006084	Iron coordination center [ion binding]; other site
1147129006085	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1147129006086	classical (c) SDRs; Region: SDR_c; cd05233
1147129006087	NAD(P) binding site [chemical binding]; other site
1147129006088	active site
1147129006089	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1147129006090	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1147129006091	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727
1147129006092	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
1147129006093	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1147129006094	ATP binding site [chemical binding]; other site
1147129006095	putative Mg++ binding site [ion binding]; other site
1147129006096	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1147129006097	nucleotide binding region [chemical binding]; other site
1147129006098	ATP-binding site [chemical binding]; other site
1147129006099	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
1147129006100	HRDC domain; Region: HRDC; pfam00570
1147129006101	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
1147129006102	Penicillinase repressor; Region: Pencillinase_R; cl17580
1147129006103	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1147129006104	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1147129006105	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1147129006106	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1147129006107	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
1147129006108	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1147129006109	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1147129006110	Walker A/P-loop; other site
1147129006111	ATP binding site [chemical binding]; other site
1147129006112	Q-loop/lid; other site
1147129006113	ABC transporter signature motif; other site
1147129006114	Walker B; other site
1147129006115	D-loop; other site
1147129006116	H-loop/switch region; other site
1147129006117	Predicted metal-binding protein (DUF2284); Region: DUF2284; pfam10050
1147129006118	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
1147129006119	Peptidase family M50; Region: Peptidase_M50; pfam02163
1147129006120	active site
1147129006121	putative substrate binding region [chemical binding]; other site
1147129006122	Cupin domain; Region: Cupin_2; cl17218
1147129006123	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
1147129006124	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
1147129006125	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1147129006126	Cation efflux family; Region: Cation_efflux; cl00316
1147129006127	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
1147129006128	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1147129006129	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1147129006130	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1147129006131	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1147129006132	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1147129006133	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1147129006134	Predicted membrane protein (DUF2127); Region: DUF2127; cl01785
1147129006135	Amino acid permease; Region: AA_permease_2; pfam13520
1147129006136	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1147129006137	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129006138	active site
1147129006139	phosphorylation site [posttranslational modification]
1147129006140	intermolecular recognition site; other site
1147129006141	dimerization interface [polypeptide binding]; other site
1147129006142	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1147129006143	DNA binding site [nucleotide binding]
1147129006144	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
1147129006145	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
1147129006146	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
1147129006147	Ligand Binding Site [chemical binding]; other site
1147129006148	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
1147129006149	GAF domain; Region: GAF_3; pfam13492
1147129006150	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1147129006151	dimer interface [polypeptide binding]; other site
1147129006152	phosphorylation site [posttranslational modification]
1147129006153	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147129006154	ATP binding site [chemical binding]; other site
1147129006155	Mg2+ binding site [ion binding]; other site
1147129006156	G-X-G motif; other site
1147129006157	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1147129006158	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129006159	active site
1147129006160	phosphorylation site [posttranslational modification]
1147129006161	intermolecular recognition site; other site
1147129006162	dimerization interface [polypeptide binding]; other site
1147129006163	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1147129006164	DNA binding site [nucleotide binding]
1147129006165	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1147129006166	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147129006167	ATP binding site [chemical binding]; other site
1147129006168	Mg2+ binding site [ion binding]; other site
1147129006169	G-X-G motif; other site
1147129006170	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1147129006171	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1147129006172	Walker A/P-loop; other site
1147129006173	ATP binding site [chemical binding]; other site
1147129006174	Q-loop/lid; other site
1147129006175	ABC transporter signature motif; other site
1147129006176	Walker B; other site
1147129006177	D-loop; other site
1147129006178	H-loop/switch region; other site
1147129006179	FtsX-like permease family; Region: FtsX; pfam02687
1147129006180	manganese transport transcriptional regulator; Provisional; Region: PRK03902
1147129006181	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1147129006182	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1147129006183	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
1147129006184	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1147129006185	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1147129006186	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1147129006187	putative substrate translocation pore; other site
1147129006188	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1147129006189	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1147129006190	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1147129006191	Spore germination protein; Region: Spore_permease; cl17796
1147129006192	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
1147129006193	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1147129006194	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
1147129006195	dimer interface [polypeptide binding]; other site
1147129006196	active site
1147129006197	metal binding site [ion binding]; metal-binding site
1147129006198	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
1147129006199	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147129006200	FeS/SAM binding site; other site
1147129006201	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
1147129006202	Pyruvate formate lyase 1; Region: PFL1; cd01678
1147129006203	coenzyme A binding site [chemical binding]; other site
1147129006204	active site
1147129006205	catalytic residues [active]
1147129006206	glycine loop; other site
1147129006207	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1147129006208	active site
1147129006209	ATP binding site [chemical binding]; other site
1147129006210	substrate binding site [chemical binding]; other site
1147129006211	activation loop (A-loop); other site
1147129006212	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1147129006213	Cation efflux family; Region: Cation_efflux; cl00316
1147129006214	Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097
1147129006215	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
1147129006216	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
1147129006217	FAD binding pocket [chemical binding]; other site
1147129006218	FAD binding motif [chemical binding]; other site
1147129006219	phosphate binding motif [ion binding]; other site
1147129006220	beta-alpha-beta structure motif; other site
1147129006221	NAD binding pocket [chemical binding]; other site
1147129006222	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
1147129006223	homodimer interface [polypeptide binding]; other site
1147129006224	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1147129006225	substrate-cofactor binding pocket; other site
1147129006226	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147129006227	catalytic residue [active]
1147129006228	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
1147129006229	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1147129006230	glutamine binding [chemical binding]; other site
1147129006231	catalytic triad [active]
1147129006232	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1147129006233	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
1147129006234	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1147129006235	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
1147129006236	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1147129006237	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
1147129006238	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1147129006239	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
1147129006240	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1147129006241	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1147129006242	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
1147129006243	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
1147129006244	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
1147129006245	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
1147129006246	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1147129006247	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
1147129006248	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
1147129006249	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
1147129006250	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
1147129006251	NADH dehydrogenase subunit B; Validated; Region: PRK06411
1147129006252	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
1147129006253	desulfoferrodoxin; Region: dfx_rbo; TIGR00320
1147129006254	Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974
1147129006255	non-heme iron binding site [ion binding]; other site
1147129006256	dimer interface [polypeptide binding]; other site
1147129006257	Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014
1147129006258	non-heme iron binding site [ion binding]; other site
1147129006259	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
1147129006260	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1147129006261	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1147129006262	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
1147129006263	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1147129006264	GAF domain; Region: GAF; pfam01590
1147129006265	Rubrerythrin [Energy production and conversion]; Region: COG1592
1147129006266	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
1147129006267	binuclear metal center [ion binding]; other site
1147129006268	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
1147129006269	iron binding site [ion binding]; other site
1147129006270	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
1147129006271	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1147129006272	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1147129006273	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1147129006274	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1147129006275	Accessory gene regulator B; Region: AgrB; pfam04647
1147129006276	sensory histidine kinase AtoS; Provisional; Region: PRK11360
1147129006277	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1147129006278	putative active site [active]
1147129006279	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1147129006280	dimer interface [polypeptide binding]; other site
1147129006281	phosphorylation site [posttranslational modification]
1147129006282	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147129006283	ATP binding site [chemical binding]; other site
1147129006284	Mg2+ binding site [ion binding]; other site
1147129006285	G-X-G motif; other site
1147129006286	pyruvate carboxylase; Reviewed; Region: PRK12999
1147129006287	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1147129006288	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1147129006289	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1147129006290	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1147129006291	active site
1147129006292	catalytic residues [active]
1147129006293	metal binding site [ion binding]; metal-binding site
1147129006294	homodimer binding site [polypeptide binding]; other site
1147129006295	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1147129006296	carboxyltransferase (CT) interaction site; other site
1147129006297	biotinylation site [posttranslational modification]; other site
1147129006298	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1147129006299	putative CheW interface [polypeptide binding]; other site
1147129006300	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1147129006301	Peptidase family M23; Region: Peptidase_M23; pfam01551
1147129006302	chromosome segregation protein; Provisional; Region: PRK01156
1147129006303	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1147129006304	Predicted transcriptional regulator [Transcription]; Region: COG2932
1147129006305	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147129006306	non-specific DNA binding site [nucleotide binding]; other site
1147129006307	salt bridge; other site
1147129006308	sequence-specific DNA binding site [nucleotide binding]; other site
1147129006309	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1147129006310	Catalytic site [active]
1147129006311	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1147129006312	FAD binding site [chemical binding]; other site
1147129006313	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1147129006314	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1147129006315	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1147129006316	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1147129006317	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1147129006318	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1147129006319	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1147129006320	IMP binding site; other site
1147129006321	dimer interface [polypeptide binding]; other site
1147129006322	partial ornithine binding site; other site
1147129006323	Response regulator receiver domain; Region: Response_reg; pfam00072
1147129006324	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129006325	active site
1147129006326	phosphorylation site [posttranslational modification]
1147129006327	intermolecular recognition site; other site
1147129006328	dimerization interface [polypeptide binding]; other site
1147129006329	PAS fold; Region: PAS; pfam00989
1147129006330	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1147129006331	putative active site [active]
1147129006332	heme pocket [chemical binding]; other site
1147129006333	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1147129006334	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1147129006335	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1147129006336	putative active site [active]
1147129006337	heme pocket [chemical binding]; other site
1147129006338	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1147129006339	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1147129006340	putative active site [active]
1147129006341	heme pocket [chemical binding]; other site
1147129006342	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1147129006343	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1147129006344	putative active site [active]
1147129006345	heme pocket [chemical binding]; other site
1147129006346	PAS domain; Region: PAS; smart00091
1147129006347	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1147129006348	putative active site [active]
1147129006349	heme pocket [chemical binding]; other site
1147129006350	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1147129006351	dimer interface [polypeptide binding]; other site
1147129006352	phosphorylation site [posttranslational modification]
1147129006353	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147129006354	ATP binding site [chemical binding]; other site
1147129006355	Mg2+ binding site [ion binding]; other site
1147129006356	G-X-G motif; other site
1147129006357	Response regulator receiver domain; Region: Response_reg; pfam00072
1147129006358	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129006359	active site
1147129006360	phosphorylation site [posttranslational modification]
1147129006361	intermolecular recognition site; other site
1147129006362	dimerization interface [polypeptide binding]; other site
1147129006363	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
1147129006364	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129006365	active site
1147129006366	phosphorylation site [posttranslational modification]
1147129006367	intermolecular recognition site; other site
1147129006368	dimerization interface [polypeptide binding]; other site
1147129006369	CheB methylesterase; Region: CheB_methylest; pfam01339
1147129006370	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1147129006371	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1147129006372	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
1147129006373	CHASE3 domain; Region: CHASE3; cl05000
1147129006374	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1147129006375	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1147129006376	dimerization interface [polypeptide binding]; other site
1147129006377	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1147129006378	dimer interface [polypeptide binding]; other site
1147129006379	putative CheW interface [polypeptide binding]; other site
1147129006380	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
1147129006381	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
1147129006382	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1147129006383	putative binding surface; other site
1147129006384	active site
1147129006385	P2 response regulator binding domain; Region: P2; pfam07194
1147129006386	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1147129006387	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147129006388	ATP binding site [chemical binding]; other site
1147129006389	Mg2+ binding site [ion binding]; other site
1147129006390	G-X-G motif; other site
1147129006391	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
1147129006392	Response regulator receiver domain; Region: Response_reg; pfam00072
1147129006393	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129006394	active site
1147129006395	phosphorylation site [posttranslational modification]
1147129006396	intermolecular recognition site; other site
1147129006397	dimerization interface [polypeptide binding]; other site
1147129006398	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1147129006399	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1147129006400	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
1147129006401	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456
1147129006402	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1147129006403	cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633
1147129006404	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1147129006405	Walker A/P-loop; other site
1147129006406	ATP binding site [chemical binding]; other site
1147129006407	Q-loop/lid; other site
1147129006408	ABC transporter signature motif; other site
1147129006409	Walker B; other site
1147129006410	D-loop; other site
1147129006411	H-loop/switch region; other site
1147129006412	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637
1147129006413	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1147129006414	Walker A/P-loop; other site
1147129006415	ATP binding site [chemical binding]; other site
1147129006416	Q-loop/lid; other site
1147129006417	ABC transporter signature motif; other site
1147129006418	Walker B; other site
1147129006419	D-loop; other site
1147129006420	H-loop/switch region; other site
1147129006421	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
1147129006422	active site
1147129006423	metal binding site [ion binding]; metal-binding site
1147129006424	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1147129006425	Spore germination protein; Region: Spore_permease; cl17796
1147129006426	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1147129006427	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1147129006428	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1147129006429	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1147129006430	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1147129006431	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1147129006432	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1147129006433	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1147129006434	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1147129006435	IMP binding site; other site
1147129006436	dimer interface [polypeptide binding]; other site
1147129006437	interdomain contacts; other site
1147129006438	partial ornithine binding site; other site
1147129006439	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1147129006440	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1147129006441	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1147129006442	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1147129006443	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1147129006444	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1147129006445	catalytic site [active]
1147129006446	subunit interface [polypeptide binding]; other site
1147129006447	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1147129006448	active site
1147129006449	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1147129006450	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1147129006451	active site
1147129006452	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1147129006453	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1147129006454	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1147129006455	Walker A/P-loop; other site
1147129006456	ATP binding site [chemical binding]; other site
1147129006457	Q-loop/lid; other site
1147129006458	ABC transporter signature motif; other site
1147129006459	Walker B; other site
1147129006460	D-loop; other site
1147129006461	H-loop/switch region; other site
1147129006462	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1147129006463	active site
1147129006464	DNA polymerase IV; Validated; Region: PRK02406
1147129006465	DNA binding site [nucleotide binding]
1147129006466	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
1147129006467	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
1147129006468	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
1147129006469	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
1147129006470	ApbE family; Region: ApbE; pfam02424
1147129006471	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
1147129006472	TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518
1147129006473	reductive dehalogenase; Region: RDH; TIGR02486
1147129006474	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
1147129006475	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
1147129006476	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
1147129006477	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1147129006478	Transposase [DNA replication, recombination, and repair]; Region: COG5421
1147129006479	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
1147129006480	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1147129006481	methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370
1147129006482	B12 binding site [chemical binding]; other site
1147129006483	reductive dehalogenase; Region: RDH; TIGR02486
1147129006484	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
1147129006485	reductive dehalogenase; Region: RDH; TIGR02486
1147129006486	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
1147129006487	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1147129006488	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1147129006489	ligand binding site [chemical binding]; other site
1147129006490	flexible hinge region; other site
1147129006491	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
1147129006492	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1147129006493	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1147129006494	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1147129006495	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
1147129006496	FMN-binding domain; Region: FMN_bind; pfam04205
1147129006497	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1147129006498	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
1147129006499	reductive dehalogenase; Region: RDH; TIGR02486
1147129006500	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1147129006501	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1147129006502	ligand binding site [chemical binding]; other site
1147129006503	flexible hinge region; other site
1147129006504	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1147129006505	FMN-binding domain; Region: FMN_bind; pfam04205
1147129006506	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1147129006507	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
1147129006508	reductive dehalogenase; Region: RDH; TIGR02486
1147129006509	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
1147129006510	Transposase domain (DUF772); Region: DUF772; pfam05598
1147129006511	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1147129006512	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1147129006513	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1147129006514	ligand binding site [chemical binding]; other site
1147129006515	flexible hinge region; other site
1147129006516	FMN-binding domain; Region: FMN_bind; pfam04205
1147129006517	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1147129006518	reductive dehalogenase; Region: RDH; TIGR02486
1147129006519	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
1147129006520	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1147129006521	Transposase; Region: HTH_Tnp_1; cl17663
1147129006522	putative transposase OrfB; Reviewed; Region: PHA02517
1147129006523	HTH-like domain; Region: HTH_21; pfam13276
1147129006524	Integrase core domain; Region: rve; pfam00665
1147129006525	Integrase core domain; Region: rve_3; pfam13683
1147129006526	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1147129006527	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1147129006528	ligand binding site [chemical binding]; other site
1147129006529	flexible hinge region; other site
1147129006530	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1147129006531	reductive dehalogenase; Region: RDH; TIGR02486
1147129006532	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
1147129006533	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1147129006534	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1147129006535	ligand binding site [chemical binding]; other site
1147129006536	flexible hinge region; other site
1147129006537	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
1147129006538	hypothetical protein; Provisional; Region: PRK11770
1147129006539	Domain of unknown function (DUF307); Region: DUF307; pfam03733
1147129006540	Domain of unknown function (DUF307); Region: DUF307; pfam03733
1147129006541	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1147129006542	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1147129006543	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1147129006544	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1147129006545	RDD family; Region: RDD; pfam06271
1147129006546	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
1147129006547	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1147129006548	tandem repeat interface [polypeptide binding]; other site
1147129006549	oligomer interface [polypeptide binding]; other site
1147129006550	active site residues [active]
1147129006551	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
1147129006552	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1147129006553	DNA binding residues [nucleotide binding]
1147129006554	drug binding residues [chemical binding]; other site
1147129006555	dimer interface [polypeptide binding]; other site
1147129006556	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1147129006557	OxaA-like protein precursor; Provisional; Region: PRK02463
1147129006558	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
1147129006559	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1147129006560	active site
1147129006561	catalytic tetrad [active]
1147129006562	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1147129006563	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129006564	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129006565	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129006566	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1147129006567	amidase catalytic site [active]
1147129006568	Zn binding residues [ion binding]; other site
1147129006569	substrate binding site [chemical binding]; other site
1147129006570	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1147129006571	Predicted transcriptional regulator [Transcription]; Region: COG2378
1147129006572	HTH domain; Region: HTH_11; pfam08279
1147129006573	WYL domain; Region: WYL; pfam13280
1147129006574	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1147129006575	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1147129006576	active site
1147129006577	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
1147129006578	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1147129006579	putative active site [active]
1147129006580	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
1147129006581	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
1147129006582	NAD(P) binding site [chemical binding]; other site
1147129006583	catalytic residues [active]
1147129006584	pyruvate phosphate dikinase; Provisional; Region: PRK09279
1147129006585	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
1147129006586	A new structural DNA glycosylase; Region: AlkD_like; cd06561
1147129006587	active site
1147129006588	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
1147129006589	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1147129006590	B12 binding site [chemical binding]; other site
1147129006591	Sensory domain found in PocR; Region: PocR; pfam10114
1147129006592	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
1147129006593	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1147129006594	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1147129006595	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
1147129006596	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
1147129006597	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
1147129006598	B12 binding site [chemical binding]; other site
1147129006599	cobalt ligand [ion binding]; other site
1147129006600	methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535
1147129006601	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
1147129006602	substrate binding pocket [chemical binding]; other site
1147129006603	dimer interface [polypeptide binding]; other site
1147129006604	inhibitor binding site; inhibition site
1147129006605	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1147129006606	Uncharacterized conserved protein [Function unknown]; Region: COG2433
1147129006607	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
1147129006608	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1147129006609	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147129006610	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1147129006611	FeS/SAM binding site; other site
1147129006612	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
1147129006613	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
1147129006614	Rubredoxin; Region: Rubredoxin; pfam00301
1147129006615	iron binding site [ion binding]; other site
1147129006616	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
1147129006617	Rubredoxin; Region: Rubredoxin; pfam00301
1147129006618	iron binding site [ion binding]; other site
1147129006619	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843
1147129006620	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1147129006621	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
1147129006622	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
1147129006623	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1147129006624	dimer interface [polypeptide binding]; other site
1147129006625	phosphorylation site [posttranslational modification]
1147129006626	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147129006627	ATP binding site [chemical binding]; other site
1147129006628	Mg2+ binding site [ion binding]; other site
1147129006629	G-X-G motif; other site
1147129006630	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1147129006631	putative binding surface; other site
1147129006632	active site
1147129006633	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1147129006634	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129006635	active site
1147129006636	phosphorylation site [posttranslational modification]
1147129006637	intermolecular recognition site; other site
1147129006638	dimerization interface [polypeptide binding]; other site
1147129006639	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1147129006640	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129006641	active site
1147129006642	phosphorylation site [posttranslational modification]
1147129006643	intermolecular recognition site; other site
1147129006644	dimerization interface [polypeptide binding]; other site
1147129006645	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1147129006646	DNA binding site [nucleotide binding]
1147129006647	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
1147129006648	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129006649	active site
1147129006650	phosphorylation site [posttranslational modification]
1147129006651	intermolecular recognition site; other site
1147129006652	dimerization interface [polypeptide binding]; other site
1147129006653	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
1147129006654	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1147129006655	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1147129006656	Walker A/P-loop; other site
1147129006657	ATP binding site [chemical binding]; other site
1147129006658	Q-loop/lid; other site
1147129006659	ABC transporter signature motif; other site
1147129006660	Walker B; other site
1147129006661	D-loop; other site
1147129006662	H-loop/switch region; other site
1147129006663	Predicted transcriptional regulators [Transcription]; Region: COG1725
1147129006664	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147129006665	DNA-binding site [nucleotide binding]; DNA binding site
1147129006666	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1147129006667	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1147129006668	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1147129006669	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1147129006670	Walker A/P-loop; other site
1147129006671	ATP binding site [chemical binding]; other site
1147129006672	Q-loop/lid; other site
1147129006673	ABC transporter signature motif; other site
1147129006674	Walker B; other site
1147129006675	D-loop; other site
1147129006676	H-loop/switch region; other site
1147129006677	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1147129006678	dimer interface [polypeptide binding]; other site
1147129006679	phosphorylation site [posttranslational modification]
1147129006680	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147129006681	ATP binding site [chemical binding]; other site
1147129006682	Mg2+ binding site [ion binding]; other site
1147129006683	G-X-G motif; other site
1147129006684	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1147129006685	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129006686	active site
1147129006687	phosphorylation site [posttranslational modification]
1147129006688	intermolecular recognition site; other site
1147129006689	dimerization interface [polypeptide binding]; other site
1147129006690	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1147129006691	DNA binding site [nucleotide binding]
1147129006692	Protein of unknown function (DUF3102); Region: DUF3102; pfam11300
1147129006693	Protein of unknown function (DUF1659); Region: DUF1659; pfam07872
1147129006694	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
1147129006695	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
1147129006696	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
1147129006697	DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525
1147129006698	BRO family, N-terminal domain; Region: Bro-N; pfam02498
1147129006699	Predicted transcriptional regulator [Transcription]; Region: COG2378
1147129006700	HTH domain; Region: HTH_11; pfam08279
1147129006701	WYL domain; Region: WYL; pfam13280
1147129006702	Isochorismatase family; Region: Isochorismatase; pfam00857
1147129006703	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
1147129006704	catalytic triad [active]
1147129006705	conserved cis-peptide bond; other site
1147129006706	Virulence protein [General function prediction only]; Region: COG3943
1147129006707	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
1147129006708	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
1147129006709	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1147129006710	sequence-specific DNA binding site [nucleotide binding]; other site
1147129006711	salt bridge; other site
1147129006712	PLD-like domain; Region: PLDc_2; pfam13091
1147129006713	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176
1147129006714	putative homodimer interface [polypeptide binding]; other site
1147129006715	putative active site [active]
1147129006716	catalytic site [active]
1147129006717	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
1147129006718	ATP binding site [chemical binding]; other site
1147129006719	Mg2+ binding site [ion binding]; other site
1147129006720	G-X-G motif; other site
1147129006721	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1147129006722	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1147129006723	ATP binding site [chemical binding]; other site
1147129006724	putative Mg++ binding site [ion binding]; other site
1147129006725	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1147129006726	nucleotide binding region [chemical binding]; other site
1147129006727	ATP-binding site [chemical binding]; other site
1147129006728	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1147129006729	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1147129006730	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1147129006731	catalytic residue [active]
1147129006732	DNA-sulfur modification-associated; Region: DndB; pfam14072
1147129006733	Protein of unknown function (DUF4007); Region: DUF4007; pfam13182
1147129006734	hypothetical protein; Provisional; Region: PRK13795
1147129006735	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1147129006736	Active Sites [active]
1147129006737	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147129006738	non-specific DNA binding site [nucleotide binding]; other site
1147129006739	salt bridge; other site
1147129006740	sequence-specific DNA binding site [nucleotide binding]; other site
1147129006741	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1147129006742	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1147129006743	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1147129006744	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
1147129006745	DNA binding residues [nucleotide binding]
1147129006746	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1147129006747	active site
1147129006748	8-oxo-dGMP binding site [chemical binding]; other site
1147129006749	nudix motif; other site
1147129006750	metal binding site [ion binding]; metal-binding site
1147129006751	Protein of unknown function (DUF1273); Region: DUF1273; cl01859
1147129006752	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
1147129006753	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1147129006754	active site
1147129006755	8-oxo-dGMP binding site [chemical binding]; other site
1147129006756	nudix motif; other site
1147129006757	metal binding site [ion binding]; metal-binding site
1147129006758	Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369
1147129006759	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
1147129006760	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
1147129006761	CDGSH-type zinc finger. Function unknown; Region: ZnF_CDGSH; smart00704
1147129006762	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
1147129006763	Part of AAA domain; Region: AAA_19; pfam13245
1147129006764	Family description; Region: UvrD_C_2; pfam13538
1147129006765	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129006766	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129006767	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129006768	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1147129006769	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1147129006770	putative active site [active]
1147129006771	putative NTP binding site [chemical binding]; other site
1147129006772	putative nucleic acid binding site [nucleotide binding]; other site
1147129006773	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
1147129006774	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1147129006775	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1147129006776	putative active site [active]
1147129006777	putative NTP binding site [chemical binding]; other site
1147129006778	putative nucleic acid binding site [nucleotide binding]; other site
1147129006779	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
1147129006780	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1147129006781	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1147129006782	SelR domain; Region: SelR; pfam01641
1147129006783	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147129006784	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147129006785	Protein of unknown function (DUF1659); Region: DUF1659; pfam07872
1147129006786	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
1147129006787	Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139
1147129006788	putative FMN binding site [chemical binding]; other site
1147129006789	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
1147129006790	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129006791	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129006792	Domain of unknown function (DUF1848); Region: DUF1848; pfam08902
1147129006793	Predicted ATPase [General function prediction only]; Region: COG3910
1147129006794	ATP-binding cassette domain of non-transporter proteins; Region: ABC_Class2; cd03227
1147129006795	Walker A/P-loop; other site
1147129006796	ATP binding site [chemical binding]; other site
1147129006797	Q-loop/lid; other site
1147129006798	ABC transporter signature motif; other site
1147129006799	Walker B; other site
1147129006800	D-loop; other site
1147129006801	H-loop/switch region; other site
1147129006802	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1147129006803	dinuclear metal binding motif [ion binding]; other site
1147129006804	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
1147129006805	Predicted transcriptional regulators [Transcription]; Region: COG1695
1147129006806	Transcriptional regulator PadR-like family; Region: PadR; cl17335
1147129006807	Membrane protein of unknown function; Region: DUF360; pfam04020
1147129006808	Protein of unknown function (DUF2089); Region: DUF2089; pfam09862
1147129006809	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1147129006810	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
1147129006811	SWIM zinc finger; Region: SWIM; pfam04434
1147129006812	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
1147129006813	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1147129006814	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1147129006815	ATP binding site [chemical binding]; other site
1147129006816	putative Mg++ binding site [ion binding]; other site
1147129006817	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1147129006818	nucleotide binding region [chemical binding]; other site
1147129006819	ATP-binding site [chemical binding]; other site
1147129006820	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1147129006821	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1147129006822	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1147129006823	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1147129006824	metal binding site [ion binding]; metal-binding site
1147129006825	active site
1147129006826	I-site; other site
1147129006827	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1147129006828	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
1147129006829	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1147129006830	active site
1147129006831	catalytic tetrad [active]
1147129006832	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1147129006833	Uncharacterized conserved protein [Function unknown]; Region: COG3339
1147129006834	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
1147129006835	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
1147129006836	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
1147129006837	putative active site [active]
1147129006838	putative metal binding site [ion binding]; other site
1147129006839	Domain of unknown function (DUF4173); Region: DUF4173; pfam13777
1147129006840	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1147129006841	salt bridge; other site
1147129006842	non-specific DNA binding site [nucleotide binding]; other site
1147129006843	sequence-specific DNA binding site [nucleotide binding]; other site
1147129006844	acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Region: accD; TIGR00515
1147129006845	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
1147129006846	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1147129006847	HSP70 interaction site [polypeptide binding]; other site
1147129006848	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1147129006849	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1147129006850	Walker A/P-loop; other site
1147129006851	ATP binding site [chemical binding]; other site
1147129006852	Q-loop/lid; other site
1147129006853	ABC transporter signature motif; other site
1147129006854	Walker B; other site
1147129006855	D-loop; other site
1147129006856	H-loop/switch region; other site
1147129006857	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1147129006858	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1147129006859	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
1147129006860	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
1147129006861	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1147129006862	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1147129006863	MarR family; Region: MarR_2; pfam12802
1147129006864	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1147129006865	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1147129006866	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
1147129006867	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1147129006868	Family of unknown function (DUF633); Region: DUF633; pfam04816
1147129006869	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
1147129006870	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1147129006871	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1147129006872	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1147129006873	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1147129006874	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1147129006875	DNA binding residues [nucleotide binding]
1147129006876	DNA primase; Validated; Region: dnaG; PRK05667
1147129006877	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1147129006878	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1147129006879	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1147129006880	active site
1147129006881	metal binding site [ion binding]; metal-binding site
1147129006882	interdomain interaction site; other site
1147129006883	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1147129006884	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
1147129006885	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1147129006886	Zn2+ binding site [ion binding]; other site
1147129006887	Mg2+ binding site [ion binding]; other site
1147129006888	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
1147129006889	pyruvate phosphate dikinase; Provisional; Region: PRK09279
1147129006890	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1147129006891	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1147129006892	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1147129006893	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1147129006894	Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618
1147129006895	HTH domain; Region: HTH_11; pfam08279
1147129006896	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
1147129006897	FOG: CBS domain [General function prediction only]; Region: COG0517
1147129006898	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
1147129006899	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1147129006900	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
1147129006901	dimer interface [polypeptide binding]; other site
1147129006902	motif 1; other site
1147129006903	active site
1147129006904	motif 2; other site
1147129006905	motif 3; other site
1147129006906	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
1147129006907	Recombination protein O N terminal; Region: RecO_N; pfam11967
1147129006908	Recombination protein O C terminal; Region: RecO_C; pfam02565
1147129006909	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1147129006910	intersubunit interface [polypeptide binding]; other site
1147129006911	active site
1147129006912	catalytic residue [active]
1147129006913	GTPase Era; Reviewed; Region: era; PRK00089
1147129006914	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1147129006915	G1 box; other site
1147129006916	GTP/Mg2+ binding site [chemical binding]; other site
1147129006917	Switch I region; other site
1147129006918	G2 box; other site
1147129006919	Switch II region; other site
1147129006920	G3 box; other site
1147129006921	G4 box; other site
1147129006922	G5 box; other site
1147129006923	KH domain; Region: KH_2; pfam07650
1147129006924	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1147129006925	active site
1147129006926	catalytic motif [active]
1147129006927	Zn binding site [ion binding]; other site
1147129006928	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
1147129006929	metal-binding heat shock protein; Provisional; Region: PRK00016
1147129006930	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
1147129006931	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
1147129006932	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1147129006933	Zn2+ binding site [ion binding]; other site
1147129006934	Mg2+ binding site [ion binding]; other site
1147129006935	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1147129006936	PhoH-like protein; Region: PhoH; pfam02562
1147129006937	Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898
1147129006938	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
1147129006939	YabP family; Region: YabP; cl06766
1147129006940	Yqey-like protein; Region: YqeY; pfam09424
1147129006941	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1147129006942	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
1147129006943	nucleotide binding site/active site [active]
1147129006944	HIT family signature motif; other site
1147129006945	catalytic residue [active]
1147129006946	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
1147129006947	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1147129006948	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147129006949	FeS/SAM binding site; other site
1147129006950	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
1147129006951	RNA methyltransferase, RsmE family; Region: TIGR00046
1147129006952	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
1147129006953	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147129006954	S-adenosylmethionine binding site [chemical binding]; other site
1147129006955	chaperone protein DnaJ; Provisional; Region: PRK10767
1147129006956	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1147129006957	HSP70 interaction site [polypeptide binding]; other site
1147129006958	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1147129006959	substrate binding site [polypeptide binding]; other site
1147129006960	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1147129006961	Zn binding sites [ion binding]; other site
1147129006962	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1147129006963	dimer interface [polypeptide binding]; other site
1147129006964	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1147129006965	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1147129006966	nucleotide binding site [chemical binding]; other site
1147129006967	NEF interaction site [polypeptide binding]; other site
1147129006968	SBD interface [polypeptide binding]; other site
1147129006969	GrpE; Region: GrpE; pfam01025
1147129006970	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1147129006971	dimer interface [polypeptide binding]; other site
1147129006972	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1147129006973	HrcA protein C terminal domain; Region: HrcA; pfam01628
1147129006974	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1147129006975	MerR family regulatory protein; Region: MerR; pfam00376
1147129006976	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
1147129006977	HemN C-terminal domain; Region: HemN_C; pfam06969
1147129006978	GTP-binding protein LepA; Provisional; Region: PRK05433
1147129006979	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1147129006980	G1 box; other site
1147129006981	putative GEF interaction site [polypeptide binding]; other site
1147129006982	GTP/Mg2+ binding site [chemical binding]; other site
1147129006983	Switch I region; other site
1147129006984	G2 box; other site
1147129006985	G3 box; other site
1147129006986	Switch II region; other site
1147129006987	G4 box; other site
1147129006988	G5 box; other site
1147129006989	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1147129006990	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1147129006991	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1147129006992	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
1147129006993	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
1147129006994	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
1147129006995	stage II sporulation protein P; Region: spore_II_P; TIGR02867
1147129006996	Winged helix-turn helix; Region: HTH_29; pfam13551
1147129006997	Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060
1147129006998	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1147129006999	active site
1147129007000	HIGH motif; other site
1147129007001	nucleotide binding site [chemical binding]; other site
1147129007002	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1147129007003	active site
1147129007004	KMSKS motif; other site
1147129007005	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
1147129007006	tRNA binding surface [nucleotide binding]; other site
1147129007007	anticodon binding site; other site
1147129007008	Helix-turn-helix domain; Region: HTH_17; pfam12728
1147129007009	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1147129007010	putative active site [active]
1147129007011	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1147129007012	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1147129007013	Walker A/P-loop; other site
1147129007014	ATP binding site [chemical binding]; other site
1147129007015	Q-loop/lid; other site
1147129007016	ABC transporter signature motif; other site
1147129007017	Walker B; other site
1147129007018	D-loop; other site
1147129007019	H-loop/switch region; other site
1147129007020	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1147129007021	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1147129007022	Walker A/P-loop; other site
1147129007023	ATP binding site [chemical binding]; other site
1147129007024	Q-loop/lid; other site
1147129007025	ABC transporter signature motif; other site
1147129007026	Walker B; other site
1147129007027	D-loop; other site
1147129007028	H-loop/switch region; other site
1147129007029	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1147129007030	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1147129007031	TM-ABC transporter signature motif; other site
1147129007032	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1147129007033	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1147129007034	TM-ABC transporter signature motif; other site
1147129007035	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1147129007036	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
1147129007037	putative ligand binding site [chemical binding]; other site
1147129007038	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1147129007039	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1147129007040	DNA polymerase III, delta subunit; Region: holA; TIGR01128
1147129007041	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1147129007042	dimer interface [polypeptide binding]; other site
1147129007043	putative CheW interface [polypeptide binding]; other site
1147129007044	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1147129007045	active site
1147129007046	Competence protein; Region: Competence; pfam03772
1147129007047	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
1147129007048	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
1147129007049	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
1147129007050	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
1147129007051	SLBB domain; Region: SLBB; pfam10531
1147129007052	comEA protein; Region: comE; TIGR01259
1147129007053	Helix-hairpin-helix motif; Region: HHH; pfam00633
1147129007054	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
1147129007055	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1147129007056	putative active site [active]
1147129007057	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1147129007058	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1147129007059	HIGH motif; other site
1147129007060	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1147129007061	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1147129007062	active site
1147129007063	KMSKS motif; other site
1147129007064	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1147129007065	tRNA binding surface [nucleotide binding]; other site
1147129007066	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
1147129007067	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1147129007068	Zn2+ binding site [ion binding]; other site
1147129007069	Mg2+ binding site [ion binding]; other site
1147129007070	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
1147129007071	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
1147129007072	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1147129007073	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1147129007074	active site
1147129007075	(T/H)XGH motif; other site
1147129007076	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
1147129007077	GTPase CgtA; Reviewed; Region: obgE; PRK12297
1147129007078	GTP1/OBG; Region: GTP1_OBG; pfam01018
1147129007079	Obg GTPase; Region: Obg; cd01898
1147129007080	G1 box; other site
1147129007081	GTP/Mg2+ binding site [chemical binding]; other site
1147129007082	Switch I region; other site
1147129007083	G2 box; other site
1147129007084	G3 box; other site
1147129007085	Switch II region; other site
1147129007086	G4 box; other site
1147129007087	G5 box; other site
1147129007088	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
1147129007089	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1147129007090	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1147129007091	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1147129007092	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
1147129007093	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1147129007094	homodimer interface [polypeptide binding]; other site
1147129007095	oligonucleotide binding site [chemical binding]; other site
1147129007096	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
1147129007097	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105
1147129007098	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
1147129007099	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
1147129007100	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1147129007101	B12 binding site [chemical binding]; other site
1147129007102	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147129007103	FeS/SAM binding site; other site
1147129007104	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1147129007105	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1147129007106	DNA binding site [nucleotide binding]
1147129007107	active site
1147129007108	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1147129007109	dinuclear metal binding motif [ion binding]; other site
1147129007110	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161
1147129007111	Peptidase family M50; Region: Peptidase_M50; pfam02163
1147129007112	active site
1147129007113	putative substrate binding region [chemical binding]; other site
1147129007114	Peptidase family M23; Region: Peptidase_M23; pfam01551
1147129007115	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1147129007116	Septum formation topological specificity factor MinE; Region: MinE; cl00538
1147129007117	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
1147129007118	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
1147129007119	Switch I; other site
1147129007120	Switch II; other site
1147129007121	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
1147129007122	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1147129007123	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1147129007124	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1147129007125	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
1147129007126	rod shape-determining protein MreC; Provisional; Region: PRK13922
1147129007127	rod shape-determining protein MreC; Region: MreC; pfam04085
1147129007128	rod shape-determining protein MreB; Provisional; Region: PRK13927
1147129007129	MreB and similar proteins; Region: MreB_like; cd10225
1147129007130	nucleotide binding site [chemical binding]; other site
1147129007131	Mg binding site [ion binding]; other site
1147129007132	putative protofilament interaction site [polypeptide binding]; other site
1147129007133	RodZ interaction site [polypeptide binding]; other site
1147129007134	hypothetical protein; Reviewed; Region: PRK00024
1147129007135	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1147129007136	MPN+ (JAMM) motif; other site
1147129007137	Zinc-binding site [ion binding]; other site
1147129007138	Maf-like protein; Region: Maf; pfam02545
1147129007139	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1147129007140	active site
1147129007141	dimer interface [polypeptide binding]; other site
1147129007142	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
1147129007143	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
1147129007144	active site
1147129007145	catalytic residues [active]
1147129007146	metal binding site [ion binding]; metal-binding site
1147129007147	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1147129007148	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
1147129007149	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
1147129007150	CoA binding domain; Region: CoA_binding; smart00881
1147129007151	Sporulation related domain; Region: SPOR; pfam05036
1147129007152	Response regulator receiver domain; Region: Response_reg; pfam00072
1147129007153	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129007154	active site
1147129007155	phosphorylation site [posttranslational modification]
1147129007156	intermolecular recognition site; other site
1147129007157	dimerization interface [polypeptide binding]; other site
1147129007158	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1147129007159	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1147129007160	metal binding site [ion binding]; metal-binding site
1147129007161	active site
1147129007162	I-site; other site
1147129007163	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1147129007164	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1147129007165	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1147129007166	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1147129007167	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1147129007168	HIGH motif; other site
1147129007169	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1147129007170	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1147129007171	active site
1147129007172	KMSKS motif; other site
1147129007173	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1147129007174	tRNA binding surface [nucleotide binding]; other site
1147129007175	anticodon binding site; other site
1147129007176	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1147129007177	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1147129007178	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1147129007179	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1147129007180	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
1147129007181	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
1147129007182	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1147129007183	active site
1147129007184	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
1147129007185	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
1147129007186	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1147129007187	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1147129007188	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1147129007189	G1 box; other site
1147129007190	GTP/Mg2+ binding site [chemical binding]; other site
1147129007191	Switch I region; other site
1147129007192	G2 box; other site
1147129007193	G3 box; other site
1147129007194	Switch II region; other site
1147129007195	G4 box; other site
1147129007196	G5 box; other site
1147129007197	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
1147129007198	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1147129007199	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147129007200	Walker A motif; other site
1147129007201	ATP binding site [chemical binding]; other site
1147129007202	Walker B motif; other site
1147129007203	arginine finger; other site
1147129007204	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1147129007205	ATP-dependent protease LonB; Region: spore_lonB; TIGR02902
1147129007206	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147129007207	Walker A motif; other site
1147129007208	ATP binding site [chemical binding]; other site
1147129007209	Walker B motif; other site
1147129007210	arginine finger; other site
1147129007211	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1147129007212	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1147129007213	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
1147129007214	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
1147129007215	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1147129007216	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
1147129007217	cobalamin binding residues [chemical binding]; other site
1147129007218	putative BtuC binding residues; other site
1147129007219	dimer interface [polypeptide binding]; other site
1147129007220	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1147129007221	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1147129007222	ABC-ATPase subunit  interface; other site
1147129007223	dimer interface [polypeptide binding]; other site
1147129007224	putative PBP binding regions; other site
1147129007225	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1147129007226	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1147129007227	Walker A/P-loop; other site
1147129007228	ATP binding site [chemical binding]; other site
1147129007229	Q-loop/lid; other site
1147129007230	ABC transporter signature motif; other site
1147129007231	Walker B; other site
1147129007232	D-loop; other site
1147129007233	H-loop/switch region; other site
1147129007234	Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955
1147129007235	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1147129007236	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1147129007237	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147129007238	Walker A motif; other site
1147129007239	ATP binding site [chemical binding]; other site
1147129007240	Walker B motif; other site
1147129007241	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1147129007242	trigger factor; Provisional; Region: tig; PRK01490
1147129007243	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1147129007244	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1147129007245	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
1147129007246	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
1147129007247	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1147129007248	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1147129007249	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1147129007250	Bacterial transcriptional regulator; Region: IclR; pfam01614
1147129007251	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1147129007252	Interdomain contacts; other site
1147129007253	Cytokine receptor motif; other site
1147129007254	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1147129007255	Interdomain contacts; other site
1147129007256	Cytokine receptor motif; other site
1147129007257	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129007258	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129007259	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129007260	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1147129007261	Interdomain contacts; other site
1147129007262	Cytokine receptor motif; other site
1147129007263	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1147129007264	Interdomain contacts; other site
1147129007265	Cytokine receptor motif; other site
1147129007266	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1147129007267	active site
1147129007268	dimerization interface [polypeptide binding]; other site
1147129007269	ribonuclease PH; Reviewed; Region: rph; PRK00173
1147129007270	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1147129007271	hexamer interface [polypeptide binding]; other site
1147129007272	active site
1147129007273	Protein of unknown function (DUF1461); Region: DUF1461; cl01862
1147129007274	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1147129007275	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147129007276	S-adenosylmethionine binding site [chemical binding]; other site
1147129007277	Fumarase C-terminus; Region: Fumerase_C; cl00795
1147129007278	fumarate hydratase; Provisional; Region: PRK06246
1147129007279	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1147129007280	MarR family; Region: MarR; pfam01047
1147129007281	Sporulation and spore germination; Region: Germane; pfam10646
1147129007282	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1147129007283	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129007284	active site
1147129007285	phosphorylation site [posttranslational modification]
1147129007286	intermolecular recognition site; other site
1147129007287	dimerization interface [polypeptide binding]; other site
1147129007288	LytTr DNA-binding domain; Region: LytTR; smart00850
1147129007289	Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551
1147129007290	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
1147129007291	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1147129007292	active site
1147129007293	catalytic triad [active]
1147129007294	oxyanion hole [active]
1147129007295	Protein of unknown function (DUF964); Region: DUF964; pfam06133
1147129007296	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
1147129007297	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1147129007298	C-terminal peptidase (prc); Region: prc; TIGR00225
1147129007299	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1147129007300	protein binding site [polypeptide binding]; other site
1147129007301	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1147129007302	Catalytic dyad [active]
1147129007303	Bacterial Ig-like domain; Region: Big_5; pfam13205
1147129007304	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1147129007305	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
1147129007306	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1147129007307	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1147129007308	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1147129007309	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1147129007310	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1147129007311	HlyD family secretion protein; Region: HlyD_3; pfam13437
1147129007312	Protein of unknown function (DUF3102); Region: DUF3102; pfam11300
1147129007313	Protein of unknown function (DUF1659); Region: DUF1659; pfam07872
1147129007314	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
1147129007315	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1147129007316	Interdomain contacts; other site
1147129007317	Cytokine receptor motif; other site
1147129007318	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129007319	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129007320	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129007321	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1147129007322	Interdomain contacts; other site
1147129007323	Cytokine receptor motif; other site
1147129007324	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1147129007325	Interdomain contacts; other site
1147129007326	Cytokine receptor motif; other site
1147129007327	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1147129007328	Interdomain contacts; other site
1147129007329	Cytokine receptor motif; other site
1147129007330	Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562
1147129007331	putative active site [active]
1147129007332	putative catalytic triad [active]
1147129007333	Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562
1147129007334	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1147129007335	Interdomain contacts; other site
1147129007336	Cytokine receptor motif; other site
1147129007337	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
1147129007338	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1147129007339	Interdomain contacts; other site
1147129007340	Cytokine receptor motif; other site
1147129007341	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1147129007342	Interdomain contacts; other site
1147129007343	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1147129007344	FtsX-like permease family; Region: FtsX; pfam02687
1147129007345	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1147129007346	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1147129007347	Walker A/P-loop; other site
1147129007348	ATP binding site [chemical binding]; other site
1147129007349	Q-loop/lid; other site
1147129007350	ABC transporter signature motif; other site
1147129007351	Walker B; other site
1147129007352	D-loop; other site
1147129007353	H-loop/switch region; other site
1147129007354	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1147129007355	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
1147129007356	HlyD family secretion protein; Region: HlyD_3; pfam13437
1147129007357	Outer membrane efflux protein; Region: OEP; pfam02321
1147129007358	Right handed beta helix region; Region: Beta_helix; pfam13229
1147129007359	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129007360	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129007361	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
1147129007362	active site
1147129007363	catalytic triad [active]
1147129007364	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129007365	Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247
1147129007366	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129007367	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129007368	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129007369	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129007370	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129007371	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
1147129007372	active site
1147129007373	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
1147129007374	Glyco_18 domain; Region: Glyco_18; smart00636
1147129007375	active site
1147129007376	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1147129007377	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1147129007378	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1147129007379	inhibitor-cofactor binding pocket; inhibition site
1147129007380	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147129007381	catalytic residue [active]
1147129007382	putative glycosyl transferase; Provisional; Region: PRK10307
1147129007383	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
1147129007384	O-Antigen ligase; Region: Wzy_C; cl04850
1147129007385	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1147129007386	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
1147129007387	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1147129007388	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1147129007389	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1147129007390	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
1147129007391	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
1147129007392	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1147129007393	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1147129007394	inhibitor-cofactor binding pocket; inhibition site
1147129007395	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147129007396	catalytic residue [active]
1147129007397	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1147129007398	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1147129007399	putative trimer interface [polypeptide binding]; other site
1147129007400	putative CoA binding site [chemical binding]; other site
1147129007401	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
1147129007402	putative trimer interface [polypeptide binding]; other site
1147129007403	putative active site [active]
1147129007404	putative substrate binding site [chemical binding]; other site
1147129007405	putative CoA binding site [chemical binding]; other site
1147129007406	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1147129007407	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1147129007408	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1147129007409	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
1147129007410	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1147129007411	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1147129007412	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
1147129007413	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
1147129007414	CoA binding domain; Region: CoA_binding; cl17356
1147129007415	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1147129007416	NAD(P) binding site [chemical binding]; other site
1147129007417	homodimer interface [polypeptide binding]; other site
1147129007418	substrate binding site [chemical binding]; other site
1147129007419	active site
1147129007420	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1147129007421	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1147129007422	catalytic residue [active]
1147129007423	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129007424	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129007425	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129007426	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1147129007427	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1147129007428	catalytic residue [active]
1147129007429	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129007430	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129007431	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129007432	Predicted integral membrane protein [Function unknown]; Region: COG5658
1147129007433	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
1147129007434	SdpI/YhfL protein family; Region: SdpI; pfam13630
1147129007435	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1147129007436	dimerization interface [polypeptide binding]; other site
1147129007437	putative DNA binding site [nucleotide binding]; other site
1147129007438	putative Zn2+ binding site [ion binding]; other site
1147129007439	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1147129007440	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1147129007441	active site
1147129007442	tetramer interface; other site
1147129007443	Clp protease; Region: CLP_protease; pfam00574
1147129007444	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1147129007445	oligomer interface [polypeptide binding]; other site
1147129007446	active site residues [active]
1147129007447	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1147129007448	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1147129007449	putative dimer interface [polypeptide binding]; other site
1147129007450	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
1147129007451	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
1147129007452	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
1147129007453	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1147129007454	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113
1147129007455	dimer interface [polypeptide binding]; other site
1147129007456	Citrate synthase; Region: Citrate_synt; pfam00285
1147129007457	active site
1147129007458	citrylCoA binding site [chemical binding]; other site
1147129007459	oxalacetate/citrate binding site [chemical binding]; other site
1147129007460	coenzyme A binding site [chemical binding]; other site
1147129007461	catalytic triad [active]
1147129007462	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
1147129007463	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
1147129007464	putative active site [active]
1147129007465	putative metal binding site [ion binding]; other site
1147129007466	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
1147129007467	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
1147129007468	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1147129007469	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
1147129007470	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
1147129007471	Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777
1147129007472	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1147129007473	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1147129007474	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1147129007475	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1147129007476	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1147129007477	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1147129007478	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1147129007479	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1147129007480	carboxyltransferase (CT) interaction site; other site
1147129007481	biotinylation site [posttranslational modification]; other site
1147129007482	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1147129007483	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1147129007484	dimer interface [polypeptide binding]; other site
1147129007485	active site
1147129007486	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1147129007487	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1147129007488	NAD(P) binding site [chemical binding]; other site
1147129007489	homotetramer interface [polypeptide binding]; other site
1147129007490	homodimer interface [polypeptide binding]; other site
1147129007491	active site
1147129007492	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1147129007493	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1147129007494	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
1147129007495	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1147129007496	FMN binding site [chemical binding]; other site
1147129007497	substrate binding site [chemical binding]; other site
1147129007498	putative catalytic residue [active]
1147129007499	acyl carrier protein; Provisional; Region: acpP; PRK00982
1147129007500	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1147129007501	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1147129007502	dimer interface [polypeptide binding]; other site
1147129007503	active site
1147129007504	CoA binding pocket [chemical binding]; other site
1147129007505	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1147129007506	MarR family; Region: MarR_2; pfam12802
1147129007507	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147129007508	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1147129007509	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147129007510	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
1147129007511	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1147129007512	CoenzymeA binding site [chemical binding]; other site
1147129007513	subunit interaction site [polypeptide binding]; other site
1147129007514	PHB binding site; other site
1147129007515	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1147129007516	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1147129007517	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1147129007518	putative active site [active]
1147129007519	heme pocket [chemical binding]; other site
1147129007520	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1147129007521	dimer interface [polypeptide binding]; other site
1147129007522	phosphorylation site [posttranslational modification]
1147129007523	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147129007524	ATP binding site [chemical binding]; other site
1147129007525	Mg2+ binding site [ion binding]; other site
1147129007526	G-X-G motif; other site
1147129007527	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
1147129007528	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129007529	active site
1147129007530	phosphorylation site [posttranslational modification]
1147129007531	intermolecular recognition site; other site
1147129007532	dimerization interface [polypeptide binding]; other site
1147129007533	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1147129007534	Zn2+ binding site [ion binding]; other site
1147129007535	Mg2+ binding site [ion binding]; other site
1147129007536	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
1147129007537	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665
1147129007538	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
1147129007539	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
1147129007540	active site
1147129007541	dimer interface [polypeptide binding]; other site
1147129007542	effector binding site; other site
1147129007543	TSCPD domain; Region: TSCPD; pfam12637
1147129007544	Domain of unknown function (DUF3787); Region: DUF3787; pfam12655
1147129007545	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1147129007546	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1147129007547	Predicted membrane protein [Function unknown]; Region: COG1511
1147129007548	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1147129007549	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
1147129007550	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1147129007551	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
1147129007552	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1147129007553	dimer interface [polypeptide binding]; other site
1147129007554	PYR/PP interface [polypeptide binding]; other site
1147129007555	TPP binding site [chemical binding]; other site
1147129007556	substrate binding site [chemical binding]; other site
1147129007557	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1147129007558	Domain of unknown function; Region: EKR; pfam10371
1147129007559	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1147129007560	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
1147129007561	TPP-binding site [chemical binding]; other site
1147129007562	dimer interface [polypeptide binding]; other site
1147129007563	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1147129007564	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1147129007565	dimerization interface [polypeptide binding]; other site
1147129007566	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1147129007567	dimer interface [polypeptide binding]; other site
1147129007568	phosphorylation site [posttranslational modification]
1147129007569	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147129007570	ATP binding site [chemical binding]; other site
1147129007571	Mg2+ binding site [ion binding]; other site
1147129007572	G-X-G motif; other site
1147129007573	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1147129007574	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129007575	active site
1147129007576	phosphorylation site [posttranslational modification]
1147129007577	intermolecular recognition site; other site
1147129007578	dimerization interface [polypeptide binding]; other site
1147129007579	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1147129007580	DNA binding site [nucleotide binding]
1147129007581	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
1147129007582	Rubredoxin; Region: Rubredoxin; pfam00301
1147129007583	iron binding site [ion binding]; other site
1147129007584	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1147129007585	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147129007586	DNA-binding site [nucleotide binding]; DNA binding site
1147129007587	FCD domain; Region: FCD; pfam07729
1147129007588	spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869
1147129007589	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1147129007590	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
1147129007591	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198
1147129007592	germination protein YpeB; Region: spore_YpeB; TIGR02889
1147129007593	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1147129007594	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
1147129007595	ligand binding site [chemical binding]; other site
1147129007596	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1147129007597	non-specific DNA interactions [nucleotide binding]; other site
1147129007598	DNA binding site [nucleotide binding]
1147129007599	sequence specific DNA binding site [nucleotide binding]; other site
1147129007600	putative cAMP binding site [chemical binding]; other site
1147129007601	Integral membrane protein TerC family; Region: TerC; cl10468
1147129007602	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1147129007603	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
1147129007604	putative ligand binding site [chemical binding]; other site
1147129007605	helicase 45; Provisional; Region: PTZ00424
1147129007606	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1147129007607	ATP binding site [chemical binding]; other site
1147129007608	Mg++ binding site [ion binding]; other site
1147129007609	motif III; other site
1147129007610	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1147129007611	nucleotide binding region [chemical binding]; other site
1147129007612	ATP-binding site [chemical binding]; other site
1147129007613	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1147129007614	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1147129007615	Walker A/P-loop; other site
1147129007616	ATP binding site [chemical binding]; other site
1147129007617	Q-loop/lid; other site
1147129007618	ABC transporter signature motif; other site
1147129007619	Walker B; other site
1147129007620	D-loop; other site
1147129007621	H-loop/switch region; other site
1147129007622	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1147129007623	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147129007624	dimer interface [polypeptide binding]; other site
1147129007625	conserved gate region; other site
1147129007626	putative PBP binding loops; other site
1147129007627	ABC-ATPase subunit interface; other site
1147129007628	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1147129007629	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1147129007630	Helix-turn-helix domain; Region: HTH_17; pfam12728
1147129007631	PBP superfamily domain; Region: PBP_like; pfam12727
1147129007632	EDD domain protein, DegV family; Region: DegV; TIGR00762
1147129007633	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1147129007634	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1147129007635	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1147129007636	dimerization interface [polypeptide binding]; other site
1147129007637	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1147129007638	dimer interface [polypeptide binding]; other site
1147129007639	phosphorylation site [posttranslational modification]
1147129007640	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147129007641	ATP binding site [chemical binding]; other site
1147129007642	Mg2+ binding site [ion binding]; other site
1147129007643	G-X-G motif; other site
1147129007644	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1147129007645	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129007646	active site
1147129007647	phosphorylation site [posttranslational modification]
1147129007648	intermolecular recognition site; other site
1147129007649	dimerization interface [polypeptide binding]; other site
1147129007650	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1147129007651	DNA binding site [nucleotide binding]
1147129007652	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1147129007653	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1147129007654	metal binding site [ion binding]; metal-binding site
1147129007655	active site
1147129007656	I-site; other site
1147129007657	aspartate aminotransferase; Provisional; Region: PRK06836
1147129007658	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1147129007659	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147129007660	homodimer interface [polypeptide binding]; other site
1147129007661	catalytic residue [active]
1147129007662	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1147129007663	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1147129007664	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1147129007665	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
1147129007666	Walker A/P-loop; other site
1147129007667	ATP binding site [chemical binding]; other site
1147129007668	Q-loop/lid; other site
1147129007669	ABC transporter signature motif; other site
1147129007670	Walker B; other site
1147129007671	D-loop; other site
1147129007672	H-loop/switch region; other site
1147129007673	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
1147129007674	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
1147129007675	cobalt transport protein CbiM; Validated; Region: PRK06265
1147129007676	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
1147129007677	PDGLE domain; Region: PDGLE; pfam13190
1147129007678	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1147129007679	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
1147129007680	Ligand binding site; other site
1147129007681	Putative Catalytic site; other site
1147129007682	DXD motif; other site
1147129007683	GtrA-like protein; Region: GtrA; pfam04138
1147129007684	Predicted membrane protein [Function unknown]; Region: COG2246
1147129007685	Response regulator receiver domain; Region: Response_reg; pfam00072
1147129007686	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129007687	active site
1147129007688	phosphorylation site [posttranslational modification]
1147129007689	intermolecular recognition site; other site
1147129007690	dimerization interface [polypeptide binding]; other site
1147129007691	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
1147129007692	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1147129007693	Zn2+ binding site [ion binding]; other site
1147129007694	Mg2+ binding site [ion binding]; other site
1147129007695	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147129007696	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1147129007697	ATP binding site [chemical binding]; other site
1147129007698	G-X-G motif; other site
1147129007699	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1147129007700	HAMP domain; Region: HAMP; pfam00672
1147129007701	dimerization interface [polypeptide binding]; other site
1147129007702	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1147129007703	dimer interface [polypeptide binding]; other site
1147129007704	phosphorylation site [posttranslational modification]
1147129007705	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1147129007706	AMP binding site [chemical binding]; other site
1147129007707	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1147129007708	thioester reductase domain; Region: Thioester-redct; TIGR01746
1147129007709	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
1147129007710	putative NAD(P) binding site [chemical binding]; other site
1147129007711	active site
1147129007712	putative substrate binding site [chemical binding]; other site
1147129007713	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1147129007714	Condensation domain; Region: Condensation; pfam00668
1147129007715	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1147129007716	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1147129007717	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1147129007718	acyl-activating enzyme (AAE) consensus motif; other site
1147129007719	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1147129007720	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1147129007721	dimerization interface [polypeptide binding]; other site
1147129007722	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1147129007723	dimer interface [polypeptide binding]; other site
1147129007724	phosphorylation site [posttranslational modification]
1147129007725	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147129007726	ATP binding site [chemical binding]; other site
1147129007727	Mg2+ binding site [ion binding]; other site
1147129007728	G-X-G motif; other site
1147129007729	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1147129007730	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129007731	active site
1147129007732	phosphorylation site [posttranslational modification]
1147129007733	intermolecular recognition site; other site
1147129007734	dimerization interface [polypeptide binding]; other site
1147129007735	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1147129007736	DNA binding site [nucleotide binding]
1147129007737	Translation elongation factor Ts [Translation, ribosomal structure and biogenesis]; Region: Tsf; COG0264
1147129007738	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1147129007739	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1147129007740	putative DNA binding site [nucleotide binding]; other site
1147129007741	putative Zn2+ binding site [ion binding]; other site
1147129007742	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1147129007743	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1147129007744	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1147129007745	Walker A/P-loop; other site
1147129007746	ATP binding site [chemical binding]; other site
1147129007747	Q-loop/lid; other site
1147129007748	ABC transporter signature motif; other site
1147129007749	Walker B; other site
1147129007750	D-loop; other site
1147129007751	H-loop/switch region; other site
1147129007752	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1147129007753	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1147129007754	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1147129007755	Walker A/P-loop; other site
1147129007756	ATP binding site [chemical binding]; other site
1147129007757	Q-loop/lid; other site
1147129007758	ABC transporter signature motif; other site
1147129007759	Walker B; other site
1147129007760	D-loop; other site
1147129007761	H-loop/switch region; other site
1147129007762	Response regulator receiver domain; Region: Response_reg; pfam00072
1147129007763	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129007764	active site
1147129007765	phosphorylation site [posttranslational modification]
1147129007766	intermolecular recognition site; other site
1147129007767	dimerization interface [polypeptide binding]; other site
1147129007768	HDOD domain; Region: HDOD; pfam08668
1147129007769	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1147129007770	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147129007771	ATP binding site [chemical binding]; other site
1147129007772	Mg2+ binding site [ion binding]; other site
1147129007773	G-X-G motif; other site
1147129007774	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1147129007775	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129007776	active site
1147129007777	phosphorylation site [posttranslational modification]
1147129007778	intermolecular recognition site; other site
1147129007779	dimerization interface [polypeptide binding]; other site
1147129007780	LytTr DNA-binding domain; Region: LytTR; pfam04397
1147129007781	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1147129007782	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1147129007783	metal binding site [ion binding]; metal-binding site
1147129007784	active site
1147129007785	I-site; other site
1147129007786	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1147129007787	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
1147129007788	oligomer interface [polypeptide binding]; other site
1147129007789	aspartate ring; other site
1147129007790	basic sphincter; other site
1147129007791	hydrophobic gate; other site
1147129007792	periplasmic entrance; other site
1147129007793	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
1147129007794	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
1147129007795	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1147129007796	active site
1147129007797	substrate binding site [chemical binding]; other site
1147129007798	metal binding site [ion binding]; metal-binding site
1147129007799	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096
1147129007800	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1147129007801	active site
1147129007802	dimer interface [polypeptide binding]; other site
1147129007803	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1147129007804	dimer interface [polypeptide binding]; other site
1147129007805	active site
1147129007806	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1147129007807	Ligand Binding Site [chemical binding]; other site
1147129007808	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963
1147129007809	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147129007810	FeS/SAM binding site; other site
1147129007811	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
1147129007812	active site
1147129007813	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
1147129007814	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869
1147129007815	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1147129007816	DRTGG domain; Region: DRTGG; pfam07085
1147129007817	CBS domain; Region: CBS; pfam00571
1147129007818	DHH family; Region: DHH; pfam01368
1147129007819	DHHA2 domain; Region: DHHA2; pfam02833
1147129007820	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
1147129007821	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
1147129007822	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1147129007823	catalytic loop [active]
1147129007824	iron binding site [ion binding]; other site
1147129007825	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1147129007826	PhoU domain; Region: PhoU; pfam01895
1147129007827	PhoU domain; Region: PhoU; pfam01895
1147129007828	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
1147129007829	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1147129007830	Walker A/P-loop; other site
1147129007831	ATP binding site [chemical binding]; other site
1147129007832	Q-loop/lid; other site
1147129007833	ABC transporter signature motif; other site
1147129007834	Walker B; other site
1147129007835	D-loop; other site
1147129007836	H-loop/switch region; other site
1147129007837	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1147129007838	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147129007839	dimer interface [polypeptide binding]; other site
1147129007840	conserved gate region; other site
1147129007841	putative PBP binding loops; other site
1147129007842	ABC-ATPase subunit interface; other site
1147129007843	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1147129007844	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1147129007845	dimer interface [polypeptide binding]; other site
1147129007846	conserved gate region; other site
1147129007847	putative PBP binding loops; other site
1147129007848	ABC-ATPase subunit interface; other site
1147129007849	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1147129007850	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1147129007851	dimerization interface [polypeptide binding]; other site
1147129007852	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1147129007853	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1147129007854	dimer interface [polypeptide binding]; other site
1147129007855	phosphorylation site [posttranslational modification]
1147129007856	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147129007857	ATP binding site [chemical binding]; other site
1147129007858	Mg2+ binding site [ion binding]; other site
1147129007859	G-X-G motif; other site
1147129007860	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1147129007861	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129007862	active site
1147129007863	phosphorylation site [posttranslational modification]
1147129007864	intermolecular recognition site; other site
1147129007865	dimerization interface [polypeptide binding]; other site
1147129007866	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1147129007867	DNA binding site [nucleotide binding]
1147129007868	PBP superfamily domain; Region: PBP_like_2; cl17296
1147129007869	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1147129007870	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1147129007871	DEAD/DEAH box helicase; Region: DEAD; pfam00270
1147129007872	ATP binding site [chemical binding]; other site
1147129007873	DEAD_2; Region: DEAD_2; pfam06733
1147129007874	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1147129007875	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
1147129007876	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113
1147129007877	dimer interface [polypeptide binding]; other site
1147129007878	active site
1147129007879	citrylCoA binding site [chemical binding]; other site
1147129007880	Citrate synthase; Region: Citrate_synt; pfam00285
1147129007881	oxalacetate/citrate binding site [chemical binding]; other site
1147129007882	coenzyme A binding site [chemical binding]; other site
1147129007883	catalytic triad [active]
1147129007884	Response regulator receiver domain; Region: Response_reg; pfam00072
1147129007885	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129007886	active site
1147129007887	phosphorylation site [posttranslational modification]
1147129007888	intermolecular recognition site; other site
1147129007889	dimerization interface [polypeptide binding]; other site
1147129007890	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1147129007891	ATP binding site [chemical binding]; other site
1147129007892	Mg2+ binding site [ion binding]; other site
1147129007893	G-X-G motif; other site
1147129007894	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1147129007895	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1147129007896	intersubunit interface [polypeptide binding]; other site
1147129007897	active site
1147129007898	zinc binding site [ion binding]; other site
1147129007899	Na+ binding site [ion binding]; other site
1147129007900	N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cd09846
1147129007901	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
1147129007902	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
1147129007903	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1147129007904	dimerization interface [polypeptide binding]; other site
1147129007905	ATP binding site [chemical binding]; other site
1147129007906	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1147129007907	dimerization interface [polypeptide binding]; other site
1147129007908	ATP binding site [chemical binding]; other site
1147129007909	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1147129007910	putative active site [active]
1147129007911	catalytic triad [active]
1147129007912	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1147129007913	Zn2+ binding site [ion binding]; other site
1147129007914	Mg2+ binding site [ion binding]; other site
1147129007915	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
1147129007916	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
1147129007917	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1147129007918	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1147129007919	Transposase [DNA replication, recombination, and repair]; Region: COG5421
1147129007920	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129007921	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129007922	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1147129007923	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
1147129007924	Protein of unknown function (DUF4003); Region: DUF4003; pfam13170
1147129007925	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1147129007926	SmpB-tmRNA interface; other site
1147129007927	Esterase/lipase [General function prediction only]; Region: COG1647
1147129007928	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
1147129007929	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
1147129007930	Preprotein translocase SecG subunit; Region: SecG; cl09123
1147129007931	enolase; Provisional; Region: eno; PRK00077
1147129007932	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1147129007933	dimer interface [polypeptide binding]; other site
1147129007934	metal binding site [ion binding]; metal-binding site
1147129007935	substrate binding pocket [chemical binding]; other site
1147129007936	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
1147129007937	phosphoglyceromutase; Provisional; Region: PRK05434
1147129007938	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1147129007939	triosephosphate isomerase; Provisional; Region: PRK14565
1147129007940	substrate binding site [chemical binding]; other site
1147129007941	dimer interface [polypeptide binding]; other site
1147129007942	catalytic triad [active]
1147129007943	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1147129007944	Phosphoglycerate kinase; Region: PGK; pfam00162
1147129007945	substrate binding site [chemical binding]; other site
1147129007946	hinge regions; other site
1147129007947	ADP binding site [chemical binding]; other site
1147129007948	catalytic site [active]
1147129007949	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1147129007950	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1147129007951	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
1147129007952	TrkA-N domain; Region: TrkA_N; pfam02254
1147129007953	TrkA-C domain; Region: TrkA_C; pfam02080
1147129007954	TrkA-N domain; Region: TrkA_N; pfam02254
1147129007955	TrkA-C domain; Region: TrkA_C; pfam02080
1147129007956	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
1147129007957	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1147129007958	Transposase [DNA replication, recombination, and repair]; Region: COG5421
1147129007959	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1147129007960	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
1147129007961	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
1147129007962	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
1147129007963	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
1147129007964	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
1147129007965	phosphate binding site [ion binding]; other site
1147129007966	putative substrate binding pocket [chemical binding]; other site
1147129007967	dimer interface [polypeptide binding]; other site
1147129007968	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
1147129007969	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1147129007970	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
1147129007971	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
1147129007972	Protein of unknown function (DUF4080); Region: DUF4080; pfam13311
1147129007973	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1147129007974	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1147129007975	active site
1147129007976	motif I; other site
1147129007977	motif II; other site
1147129007978	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1147129007979	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1147129007980	Histidine kinase; Region: HisKA_3; pfam07730
1147129007981	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1147129007982	ATP binding site [chemical binding]; other site
1147129007983	Mg2+ binding site [ion binding]; other site
1147129007984	G-X-G motif; other site
1147129007985	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1147129007986	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129007987	active site
1147129007988	phosphorylation site [posttranslational modification]
1147129007989	intermolecular recognition site; other site
1147129007990	dimerization interface [polypeptide binding]; other site
1147129007991	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1147129007992	DNA binding residues [nucleotide binding]
1147129007993	dimerization interface [polypeptide binding]; other site
1147129007994	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1147129007995	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1147129007996	Walker A/P-loop; other site
1147129007997	ATP binding site [chemical binding]; other site
1147129007998	Q-loop/lid; other site
1147129007999	ABC transporter signature motif; other site
1147129008000	Walker B; other site
1147129008001	D-loop; other site
1147129008002	H-loop/switch region; other site
1147129008003	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1147129008004	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1147129008005	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1147129008006	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1147129008007	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1147129008008	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1147129008009	oligomerization interface [polypeptide binding]; other site
1147129008010	active site
1147129008011	metal binding site [ion binding]; metal-binding site
1147129008012	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1147129008013	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1147129008014	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1147129008015	Q-loop/lid; other site
1147129008016	ABC transporter signature motif; other site
1147129008017	Walker B; other site
1147129008018	D-loop; other site
1147129008019	H-loop/switch region; other site
1147129008020	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1147129008021	excinuclease ABC subunit B; Provisional; Region: PRK05298
1147129008022	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1147129008023	ATP binding site [chemical binding]; other site
1147129008024	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1147129008025	nucleotide binding region [chemical binding]; other site
1147129008026	ATP-binding site [chemical binding]; other site
1147129008027	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1147129008028	UvrB/uvrC motif; Region: UVR; pfam02151
1147129008029	hypothetical protein; Provisional; Region: PRK06851
1147129008030	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1147129008031	C-terminal peptidase (prc); Region: prc; TIGR00225
1147129008032	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1147129008033	protein binding site [polypeptide binding]; other site
1147129008034	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1147129008035	Catalytic dyad [active]
1147129008036	AmiB activator; Provisional; Region: PRK11637
1147129008037	Regulator of replication initiation timing [Replication,    recombination, and repair]; Region: COG4467; cl01853
1147129008038	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1147129008039	Peptidase family M23; Region: Peptidase_M23; pfam01551
1147129008040	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
1147129008041	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
1147129008042	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1147129008043	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1147129008044	Walker A/P-loop; other site
1147129008045	ATP binding site [chemical binding]; other site
1147129008046	Q-loop/lid; other site
1147129008047	ABC transporter signature motif; other site
1147129008048	Walker B; other site
1147129008049	D-loop; other site
1147129008050	H-loop/switch region; other site
1147129008051	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
1147129008052	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1147129008053	PYR/PP interface [polypeptide binding]; other site
1147129008054	dimer interface [polypeptide binding]; other site
1147129008055	TPP binding site [chemical binding]; other site
1147129008056	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1147129008057	transketolase; Reviewed; Region: PRK05899
1147129008058	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1147129008059	TPP-binding site [chemical binding]; other site
1147129008060	dimer interface [polypeptide binding]; other site
1147129008061	peptide chain release factor 2; Provisional; Region: PRK05589
1147129008062	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1147129008063	RF-1 domain; Region: RF-1; pfam00472
1147129008064	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1147129008065	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1147129008066	ATP binding site [chemical binding]; other site
1147129008067	putative Mg++ binding site [ion binding]; other site
1147129008068	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1147129008069	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1147129008070	nucleotide binding region [chemical binding]; other site
1147129008071	ATP-binding site [chemical binding]; other site
1147129008072	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1147129008073	30S subunit binding site; other site
1147129008074	RecR protein; Region: RecR; pfam02132
1147129008075	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1147129008076	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1147129008077	active site
1147129008078	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
1147129008079	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1147129008080	ATP binding site [chemical binding]; other site
1147129008081	putative Mg++ binding site [ion binding]; other site
1147129008082	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1147129008083	nucleotide binding region [chemical binding]; other site
1147129008084	ATP-binding site [chemical binding]; other site
1147129008085	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1147129008086	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1147129008087	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
1147129008088	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1147129008089	rod shape-determining protein Mbl; Provisional; Region: PRK13928
1147129008090	MreB and similar proteins; Region: MreB_like; cd10225
1147129008091	nucleotide binding site [chemical binding]; other site
1147129008092	Mg binding site [ion binding]; other site
1147129008093	putative protofilament interaction site [polypeptide binding]; other site
1147129008094	RodZ interaction site [polypeptide binding]; other site
1147129008095	Stage III sporulation protein D; Region: SpoIIID; pfam12116
1147129008096	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
1147129008097	Stage II sporulation protein; Region: SpoIID; pfam08486
1147129008098	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
1147129008099	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1147129008100	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1147129008101	hinge; other site
1147129008102	active site
1147129008103	Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158
1147129008104	putative homodimer interface [polypeptide binding]; other site
1147129008105	putative homotetramer interface [polypeptide binding]; other site
1147129008106	putative metal binding site [ion binding]; other site
1147129008107	putative homodimer-homodimer interface [polypeptide binding]; other site
1147129008108	putative allosteric switch controlling residues; other site
1147129008109	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1147129008110	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
1147129008111	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
1147129008112	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
1147129008113	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1147129008114	active site
1147129008115	DNA binding site [nucleotide binding]
1147129008116	Int/Topo IB signature motif; other site
1147129008117	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1147129008118	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1147129008119	active site
1147129008120	DNA binding site [nucleotide binding]
1147129008121	Int/Topo IB signature motif; other site
1147129008122	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1147129008123	pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188
1147129008124	Int/Topo IB signature motif; other site
1147129008125	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
1147129008126	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1147129008127	putative active site [active]
1147129008128	putative NTP binding site [chemical binding]; other site
1147129008129	putative nucleic acid binding site [nucleotide binding]; other site
1147129008130	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1147129008131	gamma subunit interface [polypeptide binding]; other site
1147129008132	epsilon subunit interface [polypeptide binding]; other site
1147129008133	LBP interface [polypeptide binding]; other site
1147129008134	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1147129008135	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1147129008136	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1147129008137	alpha subunit interaction interface [polypeptide binding]; other site
1147129008138	Walker A motif; other site
1147129008139	ATP binding site [chemical binding]; other site
1147129008140	Walker B motif; other site
1147129008141	inhibitor binding site; inhibition site
1147129008142	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1147129008143	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1147129008144	core domain interface [polypeptide binding]; other site
1147129008145	delta subunit interface [polypeptide binding]; other site
1147129008146	epsilon subunit interface [polypeptide binding]; other site
1147129008147	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1147129008148	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1147129008149	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1147129008150	beta subunit interaction interface [polypeptide binding]; other site
1147129008151	Walker A motif; other site
1147129008152	ATP binding site [chemical binding]; other site
1147129008153	Walker B motif; other site
1147129008154	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1147129008155	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429
1147129008156	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1147129008157	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1147129008158	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1147129008159	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
1147129008160	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1147129008161	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1147129008162	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1147129008163	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1147129008164	active site
1147129008165	homodimer interface [polypeptide binding]; other site
1147129008166	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
1147129008167	catalytic motif [active]
1147129008168	Zn binding site [ion binding]; other site
1147129008169	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1147129008170	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1147129008171	dimer interface [polypeptide binding]; other site
1147129008172	active site
1147129008173	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1147129008174	folate binding site [chemical binding]; other site
1147129008175	hypothetical protein; Provisional; Region: PRK13690
1147129008176	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
1147129008177	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1147129008178	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1147129008179	active site
1147129008180	Predicted membrane protein [Function unknown]; Region: COG1971
1147129008181	Domain of unknown function DUF; Region: DUF204; pfam02659
1147129008182	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1147129008183	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
1147129008184	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1147129008185	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147129008186	S-adenosylmethionine binding site [chemical binding]; other site
1147129008187	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1147129008188	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1147129008189	RF-1 domain; Region: RF-1; pfam00472
1147129008190	Protein of unknown function (DUF1385); Region: DUF1385; pfam07136
1147129008191	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
1147129008192	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
1147129008193	putative active site [active]
1147129008194	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
1147129008195	active site
1147129008196	intersubunit interactions; other site
1147129008197	catalytic residue [active]
1147129008198	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129008199	Response regulator receiver domain; Region: Response_reg; pfam00072
1147129008200	active site
1147129008201	phosphorylation site [posttranslational modification]
1147129008202	intermolecular recognition site; other site
1147129008203	dimerization interface [polypeptide binding]; other site
1147129008204	alanine racemase; Reviewed; Region: alr; PRK00053
1147129008205	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1147129008206	active site
1147129008207	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1147129008208	dimer interface [polypeptide binding]; other site
1147129008209	substrate binding site [chemical binding]; other site
1147129008210	catalytic residues [active]
1147129008211	FemAB family; Region: FemAB; pfam02388
1147129008212	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
1147129008213	CTP synthetase; Validated; Region: pyrG; PRK05380
1147129008214	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1147129008215	Catalytic site [active]
1147129008216	active site
1147129008217	UTP binding site [chemical binding]; other site
1147129008218	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1147129008219	active site
1147129008220	putative oxyanion hole; other site
1147129008221	catalytic triad [active]
1147129008222	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
1147129008223	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1147129008224	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1147129008225	active site
1147129008226	HIGH motif; other site
1147129008227	KMSK motif region; other site
1147129008228	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
1147129008229	tRNA binding surface [nucleotide binding]; other site
1147129008230	anticodon binding site; other site
1147129008231	germination protein YpeB; Region: spore_YpeB; TIGR02889
1147129008232	spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869
1147129008233	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1147129008234	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
1147129008235	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1147129008236	FAD binding domain; Region: FAD_binding_4; pfam01565
1147129008237	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1147129008238	Cysteine-rich domain; Region: CCG; pfam02754
1147129008239	Cysteine-rich domain; Region: CCG; pfam02754
1147129008240	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
1147129008241	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1147129008242	catalytic residue [active]
1147129008243	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
1147129008244	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
1147129008245	putative dimer interface [polypeptide binding]; other site
1147129008246	putative anticodon binding site; other site
1147129008247	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
1147129008248	homodimer interface [polypeptide binding]; other site
1147129008249	motif 1; other site
1147129008250	motif 2; other site
1147129008251	active site
1147129008252	motif 3; other site
1147129008253	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655
1147129008254	Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986
1147129008255	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
1147129008256	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1147129008257	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1147129008258	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1147129008259	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1147129008260	intermolecular recognition site; other site
1147129008261	active site
1147129008262	dimerization interface [polypeptide binding]; other site
1147129008263	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1147129008264	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1147129008265	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1147129008266	Predicted transcriptional regulators [Transcription]; Region: COG1725
1147129008267	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1147129008268	DNA-binding site [nucleotide binding]; DNA binding site
1147129008269	phosphodiesterase YaeI; Provisional; Region: PRK11340
1147129008270	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1147129008271	putative active site [active]
1147129008272	putative metal binding site [ion binding]; other site
1147129008273	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1147129008274	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1147129008275	HflX GTPase family; Region: HflX; cd01878
1147129008276	G1 box; other site
1147129008277	GTP/Mg2+ binding site [chemical binding]; other site
1147129008278	Switch I region; other site
1147129008279	G2 box; other site
1147129008280	G3 box; other site
1147129008281	Switch II region; other site
1147129008282	G4 box; other site
1147129008283	G5 box; other site
1147129008284	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
1147129008285	UbiA prenyltransferase family; Region: UbiA; pfam01040
1147129008286	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1147129008287	hypothetical protein; Provisional; Region: PRK04194
1147129008288	preprotein translocase subunit SecA; Reviewed; Region: PRK12326
1147129008289	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
1147129008290	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1147129008291	nucleotide binding region [chemical binding]; other site
1147129008292	ATP-binding site [chemical binding]; other site
1147129008293	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1147129008294	dimer interface [polypeptide binding]; other site
1147129008295	putative CheW interface [polypeptide binding]; other site
1147129008296	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1147129008297	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1147129008298	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
1147129008299	Precorrin-8X methylmutase; Region: CbiC; pfam02570
1147129008300	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
1147129008301	active site
1147129008302	putative homodimer interface [polypeptide binding]; other site
1147129008303	SAM binding site [chemical binding]; other site
1147129008304	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1147129008305	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
1147129008306	S-adenosylmethionine binding site [chemical binding]; other site
1147129008307	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1147129008308	putative active site [active]
1147129008309	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1147129008310	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1147129008311	inhibitor-cofactor binding pocket; inhibition site
1147129008312	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1147129008313	catalytic residue [active]
1147129008314	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1147129008315	dimer interface [polypeptide binding]; other site
1147129008316	active site
1147129008317	Schiff base residues; other site
1147129008318	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1147129008319	active site
1147129008320	SAM binding site [chemical binding]; other site
1147129008321	homodimer interface [polypeptide binding]; other site
1147129008322	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
1147129008323	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1147129008324	active site
1147129008325	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1147129008326	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
1147129008327	domain interfaces; other site
1147129008328	active site
1147129008329	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
1147129008330	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
1147129008331	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
1147129008332	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1147129008333	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
1147129008334	homodimer interface [polypeptide binding]; other site
1147129008335	active site
1147129008336	SAM binding site [chemical binding]; other site
1147129008337	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1147129008338	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1147129008339	tRNA; other site
1147129008340	putative tRNA binding site [nucleotide binding]; other site
1147129008341	putative NADP binding site [chemical binding]; other site
1147129008342	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
1147129008343	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
1147129008344	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
1147129008345	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
1147129008346	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
1147129008347	active site
1147129008348	SAM binding site [chemical binding]; other site
1147129008349	homodimer interface [polypeptide binding]; other site
1147129008350	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
1147129008351	active site
1147129008352	SAM binding site [chemical binding]; other site
1147129008353	homodimer interface [polypeptide binding]; other site
1147129008354	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
1147129008355	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13636
1147129008356	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1147129008357	Walker A/P-loop; other site
1147129008358	ATP binding site [chemical binding]; other site
1147129008359	Q-loop/lid; other site
1147129008360	ABC transporter signature motif; other site
1147129008361	Walker B; other site
1147129008362	D-loop; other site
1147129008363	H-loop/switch region; other site
1147129008364	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
1147129008365	cobalt transport protein CbiN; Provisional; Region: PRK02898
1147129008366	cobalt transport protein CbiM; Validated; Region: PRK08319
1147129008367	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
1147129008368	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1147129008369	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1147129008370	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
1147129008371	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
1147129008372	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
1147129008373	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
1147129008374	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
1147129008375	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
1147129008376	Trypsin; Region: Trypsin; pfam00089
1147129008377	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1147129008378	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1147129008379	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1147129008380	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
1147129008381	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1147129008382	TPR motif; other site
1147129008383	binding surface
1147129008384	TPR repeat; Region: TPR_11; pfam13414
1147129008385	SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974
1147129008386	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1147129008387	FeS/SAM binding site; other site
1147129008388	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1147129008389	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1147129008390	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1147129008391	Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229
1147129008392	putative active site [active]
1147129008393	Zn binding site [ion binding]; other site
1147129008394	Protein of unknown function (DUF3102); Region: DUF3102; pfam11300
1147129008395	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1147129008396	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1147129008397	GDP-binding site [chemical binding]; other site
1147129008398	ACT binding site; other site
1147129008399	IMP binding site; other site
1147129008400	replicative DNA helicase; Region: DnaB; TIGR00665
1147129008401	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1147129008402	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1147129008403	Walker A motif; other site
1147129008404	ATP binding site [chemical binding]; other site
1147129008405	Walker B motif; other site
1147129008406	DNA binding loops [nucleotide binding]
1147129008407	ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903
1147129008408	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1147129008409	Walker A motif; other site
1147129008410	ATP binding site [chemical binding]; other site
1147129008411	Walker B motif; other site
1147129008412	arginine finger; other site
1147129008413	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1147129008414	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1147129008415	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1147129008416	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1147129008417	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
1147129008418	MazG-like family; Region: MazG-like; pfam12643
1147129008419	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1147129008420	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1147129008421	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1147129008422	dimer interface [polypeptide binding]; other site
1147129008423	ssDNA binding site [nucleotide binding]; other site
1147129008424	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1147129008425	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1147129008426	GTP-binding protein YchF; Reviewed; Region: PRK09601
1147129008427	YchF GTPase; Region: YchF; cd01900
1147129008428	G1 box; other site
1147129008429	GTP/Mg2+ binding site [chemical binding]; other site
1147129008430	Switch I region; other site
1147129008431	G2 box; other site
1147129008432	Switch II region; other site
1147129008433	G3 box; other site
1147129008434	G4 box; other site
1147129008435	G5 box; other site
1147129008436	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1147129008437	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
1147129008438	Colicin V production protein; Region: Colicin_V; pfam02674
1147129008439	SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain.  The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY,  and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421
1147129008440	CPxP  motif; other site
1147129008441	Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276
1147129008442	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
1147129008443	G1 box; other site
1147129008444	putative GEF interaction site [polypeptide binding]; other site
1147129008445	GTP/Mg2+ binding site [chemical binding]; other site
1147129008446	Switch I region; other site
1147129008447	G2 box; other site
1147129008448	G3 box; other site
1147129008449	Switch II region; other site
1147129008450	G4 box; other site
1147129008451	G5 box; other site
1147129008452	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
1147129008453	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
1147129008454	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
1147129008455	Protein of unknown function (DUF1256); Region: DUF1256; cl06087
1147129008456	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1147129008457	ParB-like nuclease domain; Region: ParB; smart00470
1147129008458	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1147129008459	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1147129008460	P-loop; other site
1147129008461	Magnesium ion binding site [ion binding]; other site
1147129008462	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1147129008463	Magnesium ion binding site [ion binding]; other site
1147129008464	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1147129008465	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1147129008466	S-adenosylmethionine binding site [chemical binding]; other site
1147129008467	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1147129008468	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
1147129008469	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1147129008470	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1147129008471	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1147129008472	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1147129008473	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1147129008474	G1 box; other site
1147129008475	GTP/Mg2+ binding site [chemical binding]; other site
1147129008476	Switch I region; other site
1147129008477	G2 box; other site
1147129008478	Switch II region; other site
1147129008479	G3 box; other site
1147129008480	G4 box; other site
1147129008481	G5 box; other site
1147129008482	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1147129008483	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
1147129008484	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
1147129008485	G-X-X-G motif; other site
1147129008486	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
1147129008487	RxxxH motif; other site
1147129008488	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
1147129008489	Haemolytic domain; Region: Haemolytic; pfam01809
1147129008490	ribonuclease P; Reviewed; Region: rnpA; PRK00499