-- dump date   	20140619_055808
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
216389000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
216389000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
216389000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216389000004	Walker A motif; other site
216389000005	ATP binding site [chemical binding]; other site
216389000006	arginine finger; other site
216389000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
216389000008	DnaA box-binding interface [nucleotide binding]; other site
216389000009	GTPase CgtA; Reviewed; Region: obgE; PRK12297
216389000010	GTP1/OBG; Region: GTP1_OBG; pfam01018
216389000011	Obg GTPase; Region: Obg; cd01898
216389000012	G1 box; other site
216389000013	GTP/Mg2+ binding site [chemical binding]; other site
216389000014	Switch I region; other site
216389000015	G2 box; other site
216389000016	G3 box; other site
216389000017	Switch II region; other site
216389000018	G4 box; other site
216389000019	G5 box; other site
216389000020	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
216389000021	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
216389000022	active site
216389000023	(T/H)XGH motif; other site
216389000024	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
216389000025	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216389000026	ATP binding site [chemical binding]; other site
216389000027	Mg2+ binding site [ion binding]; other site
216389000028	G-X-G motif; other site
216389000029	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
216389000030	anchoring element; other site
216389000031	dimer interface [polypeptide binding]; other site
216389000032	ATP binding site [chemical binding]; other site
216389000033	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
216389000034	active site
216389000035	putative metal-binding site [ion binding]; other site
216389000036	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
216389000037	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
216389000038	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
216389000039	Zn2+ binding site [ion binding]; other site
216389000040	Mg2+ binding site [ion binding]; other site
216389000041	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
216389000042	synthetase active site [active]
216389000043	NTP binding site [chemical binding]; other site
216389000044	metal binding site [ion binding]; metal-binding site
216389000045	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
216389000046	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
216389000047	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
216389000048	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
216389000049	dimer interface [polypeptide binding]; other site
216389000050	motif 1; other site
216389000051	active site
216389000052	motif 2; other site
216389000053	motif 3; other site
216389000054	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
216389000055	anticodon binding site; other site
216389000056	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216389000057	membrane protein; Provisional; Region: PRK14416
216389000058	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
216389000059	homodimer interface [polypeptide binding]; other site
216389000060	substrate-cofactor binding pocket; other site
216389000061	catalytic residue [active]
216389000062	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
216389000063	active site
216389000064	DNA polymerase IV; Validated; Region: PRK02406
216389000065	DNA binding site [nucleotide binding]
216389000066	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
216389000067	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
216389000068	active site
216389000069	dimer interface [polypeptide binding]; other site
216389000070	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
216389000071	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
216389000072	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
216389000073	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
216389000074	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
216389000075	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
216389000076	putative active site [active]
216389000077	dimerization interface [polypeptide binding]; other site
216389000078	putative tRNAtyr binding site [nucleotide binding]; other site
216389000079	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
216389000080	metal binding site 2 [ion binding]; metal-binding site
216389000081	putative DNA binding helix; other site
216389000082	metal binding site 1 [ion binding]; metal-binding site
216389000083	dimer interface [polypeptide binding]; other site
216389000084	structural Zn2+ binding site [ion binding]; other site
216389000085	Pleckstrin homology-like domain; Region: PH-like; cl17171
216389000086	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
216389000087	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
216389000088	Competence protein; Region: Competence; pfam03772
216389000089	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
216389000090	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
216389000091	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
216389000092	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
216389000093	TrkA-N domain; Region: TrkA_N; pfam02254
216389000094	TrkA-C domain; Region: TrkA_C; pfam02080
216389000095	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
216389000096	TrkA-N domain; Region: TrkA_N; pfam02254
216389000097	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
216389000098	Ligand Binding Site [chemical binding]; other site
216389000099	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
216389000100	Cation transport protein; Region: TrkH; cl17365
216389000101	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
216389000102	TrkA-N domain; Region: TrkA_N; pfam02254
216389000103	TrkA-C domain; Region: TrkA_C; pfam02080
216389000104	TrkA-N domain; Region: TrkA_N; pfam02254
216389000105	TrkA-C domain; Region: TrkA_C; pfam02080
216389000106	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
216389000107	TIGR00153 family protein; Region: TIGR00153
216389000108	Phosphate transporter family; Region: PHO4; pfam01384
216389000109	Guanylate kinase; Region: Guanylate_kin; pfam00625
216389000110	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
216389000111	catalytic site [active]
216389000112	G-X2-G-X-G-K; other site
216389000113	hypothetical protein; Provisional; Region: PRK04323
216389000114	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
216389000115	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
216389000116	FAD binding pocket [chemical binding]; other site
216389000117	FAD binding motif [chemical binding]; other site
216389000118	phosphate binding motif [ion binding]; other site
216389000119	beta-alpha-beta structure motif; other site
216389000120	NAD binding pocket [chemical binding]; other site
216389000121	Iron coordination center [ion binding]; other site
216389000122	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
216389000123	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691
216389000124	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
216389000125	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
216389000126	SnoaL-like domain; Region: SnoaL_3; pfam13474
216389000127	Methyltransferase domain; Region: Methyltransf_31; pfam13847
216389000128	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216389000129	S-adenosylmethionine binding site [chemical binding]; other site
216389000130	Superinfection immunity protein; Region: Imm_superinfect; pfam14373
216389000131	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
216389000132	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
216389000133	GTP-binding protein YchF; Reviewed; Region: PRK09601
216389000134	YchF GTPase; Region: YchF; cd01900
216389000135	G1 box; other site
216389000136	GTP/Mg2+ binding site [chemical binding]; other site
216389000137	Switch I region; other site
216389000138	G2 box; other site
216389000139	Switch II region; other site
216389000140	G3 box; other site
216389000141	G4 box; other site
216389000142	G5 box; other site
216389000143	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
216389000144	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912
216389000145	DNA polymerase III, delta subunit; Region: holA; TIGR01128
216389000146	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
216389000147	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
216389000148	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
216389000149	nucleotide binding site [chemical binding]; other site
216389000150	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
216389000151	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
216389000152	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
216389000153	motif 1; other site
216389000154	active site
216389000155	motif 2; other site
216389000156	motif 3; other site
216389000157	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
216389000158	FlxA-like protein; Region: FlxA; pfam14282
216389000159	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
216389000160	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
216389000161	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
216389000162	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
216389000163	active site
216389000164	NAD binding site [chemical binding]; other site
216389000165	metal binding site [ion binding]; metal-binding site
216389000166	Clp protease ATP binding subunit; Region: clpC; CHL00095
216389000167	Clp amino terminal domain; Region: Clp_N; pfam02861
216389000168	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216389000169	Walker A motif; other site
216389000170	ATP binding site [chemical binding]; other site
216389000171	Walker B motif; other site
216389000172	arginine finger; other site
216389000173	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216389000174	Walker A motif; other site
216389000175	ATP binding site [chemical binding]; other site
216389000176	Walker B motif; other site
216389000177	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
216389000178	DNA repair protein RadA; Provisional; Region: PRK11823
216389000179	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
216389000180	Walker A motif/ATP binding site; other site
216389000181	ATP binding site [chemical binding]; other site
216389000182	Walker B motif; other site
216389000183	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
216389000184	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
216389000185	substrate binding site; other site
216389000186	dimer interface; other site
216389000187	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
216389000188	homotrimer interaction site [polypeptide binding]; other site
216389000189	zinc binding site [ion binding]; other site
216389000190	CDP-binding sites; other site
216389000191	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
216389000192	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
216389000193	active site
216389000194	HIGH motif; other site
216389000195	KMSKS motif; other site
216389000196	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
216389000197	tRNA binding surface [nucleotide binding]; other site
216389000198	anticodon binding site; other site
216389000199	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
216389000200	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
216389000201	active site
216389000202	DNA binding site [nucleotide binding]
216389000203	Int/Topo IB signature motif; other site
216389000204	BRO family, N-terminal domain; Region: Bro-N; smart01040
216389000205	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216389000206	non-specific DNA binding site [nucleotide binding]; other site
216389000207	salt bridge; other site
216389000208	sequence-specific DNA binding site [nucleotide binding]; other site
216389000209	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
216389000210	active site
216389000211	metal binding site [ion binding]; metal-binding site
216389000212	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
216389000213	Lipopolysaccharide-assembly; Region: LptE; cl01125
216389000214	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
216389000215	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
216389000216	catalytic residues [active]
216389000217	catalytic nucleophile [active]
216389000218	Presynaptic Site I dimer interface [polypeptide binding]; other site
216389000219	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
216389000220	Synaptic Flat tetramer interface [polypeptide binding]; other site
216389000221	Synaptic Site I dimer interface [polypeptide binding]; other site
216389000222	DNA binding site [nucleotide binding]
216389000223	CHC2 zinc finger; Region: zf-CHC2; cl17510
216389000224	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
216389000225	active site
216389000226	metal binding site [ion binding]; metal-binding site
216389000227	interdomain interaction site; other site
216389000228	Domain of unknown function (DUF927); Region: DUF927; cl12098
216389000229	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
216389000230	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216389000231	non-specific DNA binding site [nucleotide binding]; other site
216389000232	salt bridge; other site
216389000233	sequence-specific DNA binding site [nucleotide binding]; other site
216389000234	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
216389000235	Catalytic site [active]
216389000236	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
216389000237	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
216389000238	active site
216389000239	DNA binding site [nucleotide binding]
216389000240	Int/Topo IB signature motif; other site
216389000241	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
216389000242	cofactor binding site; other site
216389000243	DNA binding site [nucleotide binding]
216389000244	substrate interaction site [chemical binding]; other site
216389000245	NgoPII restriction endonuclease; Region: RE_NgoPII; pfam09521
216389000246	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
216389000247	Transposase; Region: HTH_Tnp_1; cl17663
216389000248	HTH-like domain; Region: HTH_21; pfam13276
216389000249	Integrase core domain; Region: rve; pfam00665
216389000250	DDE domain; Region: DDE_Tnp_IS240; pfam13610
216389000251	Integrase core domain; Region: rve_3; pfam13683
216389000252	Replication initiation factor; Region: Rep_trans; pfam02486
216389000253	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
216389000254	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
216389000255	ssDNA binding site [nucleotide binding]; other site
216389000256	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
216389000257	dimer interface [polypeptide binding]; other site
216389000258	tetramer (dimer of dimers) interface [polypeptide binding]; other site
216389000259	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
216389000260	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216389000261	non-specific DNA binding site [nucleotide binding]; other site
216389000262	salt bridge; other site
216389000263	sequence-specific DNA binding site [nucleotide binding]; other site
216389000264	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
216389000265	Catalytic site [active]
216389000266	Protein of unknown function (DUF3644); Region: DUF3644; pfam12358
216389000267	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
216389000268	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
216389000269	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
216389000270	catalytic residues [active]
216389000271	catalytic nucleophile [active]
216389000272	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216389000273	non-specific DNA binding site [nucleotide binding]; other site
216389000274	salt bridge; other site
216389000275	sequence-specific DNA binding site [nucleotide binding]; other site
216389000276	Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955
216389000277	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
216389000278	reductive dehalogenase; Region: RDH; TIGR02486
216389000279	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
216389000280	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
216389000281	Ligand Binding Site [chemical binding]; other site
216389000282	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
216389000283	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216389000284	active site
216389000285	phosphorylation site [posttranslational modification]
216389000286	intermolecular recognition site; other site
216389000287	dimerization interface [polypeptide binding]; other site
216389000288	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
216389000289	DNA binding site [nucleotide binding]
216389000290	PAS domain S-box; Region: sensory_box; TIGR00229
216389000291	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216389000292	putative active site [active]
216389000293	heme pocket [chemical binding]; other site
216389000294	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
216389000295	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216389000296	dimer interface [polypeptide binding]; other site
216389000297	phosphorylation site [posttranslational modification]
216389000298	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216389000299	ATP binding site [chemical binding]; other site
216389000300	Mg2+ binding site [ion binding]; other site
216389000301	G-X-G motif; other site
216389000302	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
216389000303	B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013
216389000304	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216389000305	FeS/SAM binding site; other site
216389000306	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216389000307	FeS/SAM binding site; other site
216389000308	Radical SAM superfamily; Region: Radical_SAM; pfam04055
216389000309	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_IV; cd01994
216389000310	Ligand Binding Site [chemical binding]; other site
216389000311	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
216389000312	reductive dehalogenase; Region: RDH; TIGR02486
216389000313	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
216389000314	Putative zinc- or iron-chelating domain; Region: CxxCxxCC; pfam03692
216389000315	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216389000316	PAS domain; Region: PAS_9; pfam13426
216389000317	Histidine kinase; Region: HisKA_3; pfam07730
216389000318	HTH-like domain; Region: HTH_21; pfam13276
216389000319	Integrase core domain; Region: rve; pfam00665
216389000320	Integrase core domain; Region: rve_3; pfam13683
216389000321	Transposase; Region: HTH_Tnp_1; pfam01527
216389000322	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
216389000323	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
216389000324	reductive dehalogenase; Region: RDH; TIGR02486
216389000325	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
216389000326	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
216389000327	reductive dehalogenase; Region: RDH; TIGR02486
216389000328	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
216389000329	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216389000330	PAS domain; Region: PAS_9; pfam13426
216389000331	putative active site [active]
216389000332	heme pocket [chemical binding]; other site
216389000333	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
216389000334	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216389000335	dimer interface [polypeptide binding]; other site
216389000336	phosphorylation site [posttranslational modification]
216389000337	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216389000338	ATP binding site [chemical binding]; other site
216389000339	Mg2+ binding site [ion binding]; other site
216389000340	G-X-G motif; other site
216389000341	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
216389000342	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216389000343	active site
216389000344	phosphorylation site [posttranslational modification]
216389000345	intermolecular recognition site; other site
216389000346	dimerization interface [polypeptide binding]; other site
216389000347	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
216389000348	DNA binding site [nucleotide binding]
216389000349	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
216389000350	Double zinc ribbon; Region: DZR; pfam12773
216389000351	TM2 domain; Region: TM2; pfam05154
216389000352	Hydrogenase expression/synthesis hypA family; Region: HypA; cl19201
216389000353	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
216389000354	flavoprotein, HI0933 family; Region: TIGR00275
216389000355	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
216389000356	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
216389000357	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
216389000358	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
216389000359	ABC transporter; Region: ABC_tran_2; pfam12848
216389000360	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
216389000361	Haemolysin-III related; Region: HlyIII; cl03831
216389000362	SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172
216389000363	reactive center loop; other site
216389000364	lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820
216389000365	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216389000366	FeS/SAM binding site; other site
216389000367	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
216389000368	putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827
216389000369	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216389000370	Coenzyme A binding pocket [chemical binding]; other site
216389000371	HEAT repeats; Region: HEAT_2; pfam13646
216389000372	Predicted DNA-binding proteins [General function prediction only]; Region: COG1342
216389000373	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
216389000374	DNA binding residues [nucleotide binding]
216389000375	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
216389000376	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
216389000377	active site
216389000378	catalytic tetrad [active]
216389000379	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
216389000380	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
216389000381	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
216389000382	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
216389000383	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
216389000384	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
216389000385	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
216389000386	Methyltransferase domain; Region: Methyltransf_31; pfam13847
216389000387	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216389000388	S-adenosylmethionine binding site [chemical binding]; other site
216389000389	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
216389000390	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
216389000391	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
216389000392	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
216389000393	active site
216389000394	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
216389000395	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
216389000396	active site
216389000397	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
216389000398	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
216389000399	dimer interface [polypeptide binding]; other site
216389000400	active site
216389000401	Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605
216389000402	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
216389000403	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
216389000404	WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915
216389000405	Substrate binding site; other site
216389000406	Mg++ binding site; other site
216389000407	metal-binding site
216389000408	Mg++ binding site; other site
216389000409	metal-binding site
216389000410	UDP-glucose 4 epimerase, subgroup 2, extended (e) SDRs; Region: UDP_G4E_2_SDR_e; cd05234
216389000411	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
216389000412	NAD binding site [chemical binding]; other site
216389000413	homodimer interface [polypeptide binding]; other site
216389000414	active site
216389000415	putative substrate binding site [chemical binding]; other site
216389000416	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
216389000417	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
216389000418	active site
216389000419	hypothetical protein; Validated; Region: PRK06769
216389000420	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216389000421	active site
216389000422	motif I; other site
216389000423	motif II; other site
216389000424	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
216389000425	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
216389000426	Ligand binding site; other site
216389000427	Putative Catalytic site; other site
216389000428	DXD motif; other site
216389000429	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
216389000430	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
216389000431	Protein of unknown function (DUF1616); Region: DUF1616; pfam07760
216389000432	Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977
216389000433	Rubredoxin [Energy production and conversion]; Region: COG1773
216389000434	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
216389000435	iron binding site [ion binding]; other site
216389000436	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
216389000437	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
216389000438	catalytic residues [active]
216389000439	Protein of unknown function (DUF2769); Region: DUF2769; pfam10967
216389000440	GrpB protein; Region: GrpB; pfam04229
216389000441	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
216389000442	HI0933-like protein; Region: HI0933_like; pfam03486
216389000443	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
216389000444	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
216389000445	active site
216389000446	HIGH motif; other site
216389000447	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
216389000448	KMSKS motif; other site
216389000449	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
216389000450	tRNA binding surface [nucleotide binding]; other site
216389000451	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
216389000452	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
216389000453	Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748
216389000454	Colicin V production protein; Region: Colicin_V; pfam02674
216389000455	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
216389000456	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
216389000457	active site
216389000458	(T/H)XGH motif; other site
216389000459	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216389000460	S-adenosylmethionine binding site [chemical binding]; other site
216389000461	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
216389000462	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
216389000463	[4Fe-4S] binding site [ion binding]; other site
216389000464	molybdopterin cofactor binding site; other site
216389000465	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
216389000466	molybdopterin cofactor binding site; other site
216389000467	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
216389000468	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
216389000469	Protein involved in formate dehydrogenase formation; Region: FdhE; cl19312
216389000470	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
216389000471	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
216389000472	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
216389000473	ATP binding site [chemical binding]; other site
216389000474	Mg++ binding site [ion binding]; other site
216389000475	motif III; other site
216389000476	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216389000477	nucleotide binding region [chemical binding]; other site
216389000478	ATP-binding site [chemical binding]; other site
216389000479	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
216389000480	Cleavage inducing molecular chaperone; Region: Jiv90; pfam14901
216389000481	Integrase core domain; Region: rve; pfam00665
216389000482	DDE domain; Region: DDE_Tnp_IS240; pfam13610
216389000483	Integrase core domain; Region: rve_3; pfam13683
216389000484	formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811
216389000485	reductive dehalogenase; Region: RDH; TIGR02486
216389000486	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
216389000487	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
216389000488	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216389000489	dimer interface [polypeptide binding]; other site
216389000490	phosphorylation site [posttranslational modification]
216389000491	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216389000492	ATP binding site [chemical binding]; other site
216389000493	Mg2+ binding site [ion binding]; other site
216389000494	G-X-G motif; other site
216389000495	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
216389000496	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216389000497	active site
216389000498	phosphorylation site [posttranslational modification]
216389000499	intermolecular recognition site; other site
216389000500	dimerization interface [polypeptide binding]; other site
216389000501	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216389000502	DNA binding site [nucleotide binding]
216389000503	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
216389000504	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
216389000505	Domain of unknown function (DUF4209); Region: DUF4209; pfam13910
216389000506	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
216389000507	N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178
216389000508	PLD-like domain; Region: PLDc_2; pfam13091
216389000509	putative homodimer interface [polypeptide binding]; other site
216389000510	putative active site [active]
216389000511	catalytic site [active]
216389000512	DEAD-like helicases superfamily; Region: DEXDc; smart00487
216389000513	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
216389000514	ATP binding site [chemical binding]; other site
216389000515	putative Mg++ binding site [ion binding]; other site
216389000516	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216389000517	nucleotide binding region [chemical binding]; other site
216389000518	ATP-binding site [chemical binding]; other site
216389000519	Chain length determinant protein; Region: Wzz; cl19730
216389000520	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
216389000521	beta-clamp/clamp loader binding surface; other site
216389000522	beta-clamp/translesion DNA polymerase binding surface; other site
216389000523	Fic family protein [Function unknown]; Region: COG3177
216389000524	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
216389000525	Fic/DOC family; Region: Fic; pfam02661
216389000526	HTH DNA binding domain; Region: HTH_13; pfam11972
216389000527	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
216389000528	Domain of unknown function (DUF955); Region: DUF955; cl01076
216389000529	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
216389000530	active site
216389000531	DNA binding site [nucleotide binding]
216389000532	Int/Topo IB signature motif; other site
216389000533	Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487
216389000534	Subtilase family; Region: Peptidase_S8; pfam00082
216389000535	active site
216389000536	catalytic triad [active]
216389000537	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393
216389000538	DNA-binding interface [nucleotide binding]; DNA binding site
216389000539	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216389000540	Walker B motif; other site
216389000541	arginine finger; other site
216389000542	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
216389000543	active site
216389000544	metal binding site [ion binding]; metal-binding site
216389000545	interdomain interaction site; other site
216389000546	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
216389000547	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216389000548	non-specific DNA binding site [nucleotide binding]; other site
216389000549	salt bridge; other site
216389000550	sequence-specific DNA binding site [nucleotide binding]; other site
216389000551	Domain of unknown function (DUF955); Region: DUF955; cl01076
216389000552	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
216389000553	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
216389000554	catalytic residues [active]
216389000555	catalytic nucleophile [active]
216389000556	Recombinase; Region: Recombinase; pfam07508
216389000557	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
216389000558	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
216389000559	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
216389000560	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
216389000561	tetramer interface [polypeptide binding]; other site
216389000562	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216389000563	catalytic residue [active]
216389000564	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
216389000565	EamA-like transporter family; Region: EamA; pfam00892
216389000566	EamA-like transporter family; Region: EamA; pfam00892
216389000567	Protein of unknown function DUF45; Region: DUF45; pfam01863
216389000568	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
216389000569	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
216389000570	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
216389000571	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
216389000572	catalytic loop [active]
216389000573	iron binding site [ion binding]; other site
216389000574	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
216389000575	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
216389000576	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
216389000577	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
216389000578	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; smart00902
216389000579	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
216389000580	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
216389000581	SLBB domain; Region: SLBB; pfam10531
216389000582	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
216389000583	Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257
216389000584	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
216389000585	putative dimer interface [polypeptide binding]; other site
216389000586	[2Fe-2S] cluster binding site [ion binding]; other site
216389000587	Low molecular weight phosphatase family; Region: LMWPc; cd00115
216389000588	active site
216389000589	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
216389000590	PhoU domain; Region: PhoU; pfam01895
216389000591	PhoU domain; Region: PhoU; pfam01895
216389000592	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14249
216389000593	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
216389000594	Walker A/P-loop; other site
216389000595	ATP binding site [chemical binding]; other site
216389000596	Q-loop/lid; other site
216389000597	ABC transporter signature motif; other site
216389000598	Walker B; other site
216389000599	D-loop; other site
216389000600	H-loop/switch region; other site
216389000601	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
216389000602	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216389000603	dimer interface [polypeptide binding]; other site
216389000604	conserved gate region; other site
216389000605	putative PBP binding loops; other site
216389000606	ABC-ATPase subunit interface; other site
216389000607	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
216389000608	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216389000609	dimer interface [polypeptide binding]; other site
216389000610	conserved gate region; other site
216389000611	putative PBP binding loops; other site
216389000612	ABC-ATPase subunit interface; other site
216389000613	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
216389000614	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
216389000615	active site
216389000616	dimer interfaces [polypeptide binding]; other site
216389000617	catalytic residues [active]
216389000618	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
216389000619	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216389000620	dimerization interface [polypeptide binding]; other site
216389000621	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216389000622	putative active site [active]
216389000623	heme pocket [chemical binding]; other site
216389000624	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216389000625	dimer interface [polypeptide binding]; other site
216389000626	phosphorylation site [posttranslational modification]
216389000627	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216389000628	ATP binding site [chemical binding]; other site
216389000629	Mg2+ binding site [ion binding]; other site
216389000630	G-X-G motif; other site
216389000631	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
216389000632	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216389000633	active site
216389000634	phosphorylation site [posttranslational modification]
216389000635	intermolecular recognition site; other site
216389000636	dimerization interface [polypeptide binding]; other site
216389000637	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216389000638	DNA binding site [nucleotide binding]
216389000639	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
216389000640	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
216389000641	DNA polymerase, archaeal type II, large subunit; Region: polC; TIGR00354
216389000642	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
216389000643	Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124
216389000644	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
216389000645	Response regulator receiver domain; Region: Response_reg; pfam00072
216389000646	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216389000647	active site
216389000648	phosphorylation site [posttranslational modification]
216389000649	intermolecular recognition site; other site
216389000650	dimerization interface [polypeptide binding]; other site
216389000651	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
216389000652	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216389000653	active site
216389000654	phosphorylation site [posttranslational modification]
216389000655	intermolecular recognition site; other site
216389000656	dimerization interface [polypeptide binding]; other site
216389000657	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
216389000658	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
216389000659	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
216389000660	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
216389000661	catalytic triad [active]
216389000662	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
216389000663	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
216389000664	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
216389000665	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
216389000666	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
216389000667	NAD(P) binding site [chemical binding]; other site
216389000668	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
216389000669	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
216389000670	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
216389000671	NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493
216389000672	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
216389000673	4Fe-4S binding domain; Region: Fer4; pfam00037
216389000674	2TM domain; Region: 2TM; pfam13239
216389000675	pyruvate carboxylase subunit A; Validated; Region: PRK08654
216389000676	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
216389000677	ATP-grasp domain; Region: ATP-grasp_4; cl17255
216389000678	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
216389000679	pyruvate carboxylase subunit B; Validated; Region: PRK09282
216389000680	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
216389000681	active site
216389000682	catalytic residues [active]
216389000683	metal binding site [ion binding]; metal-binding site
216389000684	homodimer binding site [polypeptide binding]; other site
216389000685	Conserved carboxylase domain; Region: PYC_OADA; pfam02436
216389000686	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
216389000687	carboxyltransferase (CT) interaction site; other site
216389000688	biotinylation site [posttranslational modification]; other site
216389000689	DJ-1 family protein; Region: not_thiJ; TIGR01383
216389000690	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
216389000691	conserved cys residue [active]
216389000692	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216389000693	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216389000694	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
216389000695	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216389000696	Walker A/P-loop; other site
216389000697	ATP binding site [chemical binding]; other site
216389000698	Q-loop/lid; other site
216389000699	ABC transporter signature motif; other site
216389000700	Walker B; other site
216389000701	D-loop; other site
216389000702	H-loop/switch region; other site
216389000703	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
216389000704	Acyltransferase family; Region: Acyl_transf_3; cl19154
216389000705	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
216389000706	ABC-2 type transporter; Region: ABC2_membrane; cl17235
216389000707	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
216389000708	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
216389000709	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
216389000710	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
216389000711	NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720
216389000712	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
216389000713	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
216389000714	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
216389000715	putative substrate-binding site; other site
216389000716	nickel binding site [ion binding]; other site
216389000717	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
216389000718	putative catalytic site [active]
216389000719	putative metal binding site [ion binding]; other site
216389000720	putative phosphate binding site [ion binding]; other site
216389000721	E3 Ubiquitin ligase; Region: GIDE; pfam12483
216389000722	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
216389000723	EDD domain protein, DegV family; Region: DegV; TIGR00762
216389000724	Domain of unknown function DUF59; Region: DUF59; cl00941
216389000725	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
216389000726	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
216389000727	Walker A motif; other site
216389000728	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
216389000729	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
216389000730	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
216389000731	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
216389000732	tetrathionate reductase subunit A; Provisional; Region: PRK14991
216389000733	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
216389000734	molybdopterin cofactor binding site; other site
216389000735	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
216389000736	putative molybdopterin cofactor binding site; other site
216389000737	NTPase; Region: NTPase_1; cl17478
216389000738	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
216389000739	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
216389000740	GTP binding site; other site
216389000741	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
216389000742	dinuclear metal binding motif [ion binding]; other site
216389000743	Transposase; Region: HTH_Tnp_1; pfam01527
216389000744	HTH-like domain; Region: HTH_21; pfam13276
216389000745	Integrase core domain; Region: rve; pfam00665
216389000746	Integrase core domain; Region: rve_3; pfam13683
216389000747	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
216389000748	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216389000749	active site
216389000750	phosphorylation site [posttranslational modification]
216389000751	intermolecular recognition site; other site
216389000752	dimerization interface [polypeptide binding]; other site
216389000753	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216389000754	DNA binding site [nucleotide binding]
216389000755	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
216389000756	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
216389000757	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
216389000758	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216389000759	dimer interface [polypeptide binding]; other site
216389000760	phosphorylation site [posttranslational modification]
216389000761	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216389000762	ATP binding site [chemical binding]; other site
216389000763	Mg2+ binding site [ion binding]; other site
216389000764	G-X-G motif; other site
216389000765	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
216389000766	reductive dehalogenase; Region: RDH; TIGR02486
216389000767	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
216389000768	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
216389000769	B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013
216389000770	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216389000771	FeS/SAM binding site; other site
216389000772	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216389000773	FeS/SAM binding site; other site
216389000774	Radical SAM superfamily; Region: Radical_SAM; pfam04055
216389000775	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
216389000776	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
216389000777	reductive dehalogenase; Region: RDH; TIGR02486
216389000778	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
216389000779	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
216389000780	reductive dehalogenase; Region: RDH; TIGR02486
216389000781	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
216389000782	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_IV; cd01994
216389000783	Ligand Binding Site [chemical binding]; other site
216389000784	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
216389000785	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216389000786	active site
216389000787	phosphorylation site [posttranslational modification]
216389000788	intermolecular recognition site; other site
216389000789	dimerization interface [polypeptide binding]; other site
216389000790	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216389000791	DNA binding site [nucleotide binding]
216389000792	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216389000793	ATP binding site [chemical binding]; other site
216389000794	Mg2+ binding site [ion binding]; other site
216389000795	G-X-G motif; other site
216389000796	Transposase; Region: HTH_Tnp_1; pfam01527
216389000797	HTH-like domain; Region: HTH_21; pfam13276
216389000798	Integrase core domain; Region: rve; pfam00665
216389000799	Integrase core domain; Region: rve_3; pfam13683
216389000800	PAS domain S-box; Region: sensory_box; TIGR00229
216389000801	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216389000802	putative active site [active]
216389000803	heme pocket [chemical binding]; other site
216389000804	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216389000805	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
216389000806	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216389000807	putative active site [active]
216389000808	heme pocket [chemical binding]; other site
216389000809	PAS domain S-box; Region: sensory_box; TIGR00229
216389000810	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216389000811	putative active site [active]
216389000812	heme pocket [chemical binding]; other site
216389000813	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216389000814	dimer interface [polypeptide binding]; other site
216389000815	phosphorylation site [posttranslational modification]
216389000816	HTH-like domain; Region: HTH_21; pfam13276
216389000817	Integrase core domain; Region: rve; pfam00665
216389000818	DDE domain; Region: DDE_Tnp_IS240; pfam13610
216389000819	Integrase core domain; Region: rve_3; pfam13683
216389000820	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
216389000821	Transposase; Region: HTH_Tnp_1; cl17663
216389000822	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
216389000823	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216389000824	ATP binding site [chemical binding]; other site
216389000825	Mg2+ binding site [ion binding]; other site
216389000826	G-X-G motif; other site
216389000827	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
216389000828	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216389000829	active site
216389000830	phosphorylation site [posttranslational modification]
216389000831	intermolecular recognition site; other site
216389000832	dimerization interface [polypeptide binding]; other site
216389000833	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216389000834	DNA binding residues [nucleotide binding]
216389000835	dimerization interface [polypeptide binding]; other site
216389000836	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
216389000837	reductive dehalogenase; Region: RDH; TIGR02486
216389000838	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
216389000839	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
216389000840	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216389000841	non-specific DNA binding site [nucleotide binding]; other site
216389000842	salt bridge; other site
216389000843	sequence-specific DNA binding site [nucleotide binding]; other site
216389000844	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
216389000845	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
216389000846	catalytic residues [active]
216389000847	catalytic nucleophile [active]
216389000848	Recombinase; Region: Recombinase; pfam07508
216389000849	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
216389000850	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
216389000851	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
216389000852	nucleophile elbow; other site
216389000853	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
216389000854	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
216389000855	HerA helicase [Replication, recombination, and repair]; Region: COG0433
216389000856	HAS barrel domain; Region: HAS-barrel; pfam09378
216389000857	Domain of unknown function DUF87; Region: DUF87; pfam01935
216389000858	NurA nuclease; Region: NurA; smart00933
216389000859	LysE type translocator; Region: LysE; pfam01810
216389000860	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
216389000861	active site
216389000862	Zn binding site [ion binding]; other site
216389000863	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
216389000864	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
216389000865	Protein export membrane protein; Region: SecD_SecF; pfam02355
216389000866	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
216389000867	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
216389000868	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
216389000869	active site
216389000870	NTP binding site [chemical binding]; other site
216389000871	metal binding triad [ion binding]; metal-binding site
216389000872	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
216389000873	Zn2+ binding site [ion binding]; other site
216389000874	Mg2+ binding site [ion binding]; other site
216389000875	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216389000876	non-specific DNA binding site [nucleotide binding]; other site
216389000877	salt bridge; other site
216389000878	sequence-specific DNA binding site [nucleotide binding]; other site
216389000879	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
216389000880	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
216389000881	ATP binding site [chemical binding]; other site
216389000882	putative Mg++ binding site [ion binding]; other site
216389000883	Trm112p-like protein; Region: Trm112p; cl01066
216389000884	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
216389000885	ATP-binding site [chemical binding]; other site
216389000886	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
216389000887	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
216389000888	cell division protein MraZ; Reviewed; Region: PRK00326
216389000889	MraZ protein; Region: MraZ; pfam02381
216389000890	MraZ protein; Region: MraZ; pfam02381
216389000891	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
216389000892	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
216389000893	Cell division protein FtsA; Region: FtsA; smart00842
216389000894	Cell division protein FtsA; Region: FtsA; pfam14450
216389000895	cell division protein FtsZ; Validated; Region: PRK09330
216389000896	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
216389000897	nucleotide binding site [chemical binding]; other site
216389000898	SulA interaction site; other site
216389000899	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
216389000900	ATP cone domain; Region: ATP-cone; pfam03477
216389000901	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665
216389000902	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
216389000903	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
216389000904	active site
216389000905	dimer interface [polypeptide binding]; other site
216389000906	effector binding site; other site
216389000907	TSCPD domain; Region: TSCPD; pfam12637
216389000908	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
216389000909	Uncharacterized conserved protein [Function unknown]; Region: COG1432
216389000910	LabA_like proteins; Region: LabA_like; cd06167
216389000911	putative metal binding site [ion binding]; other site
216389000912	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
216389000913	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216389000914	FeS/SAM binding site; other site
216389000915	Yqey-like protein; Region: YqeY; pfam09424
216389000916	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
216389000917	Mor transcription activator family; Region: Mor; cl02360
216389000918	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; cl19531
216389000919	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
216389000920	Phage capsid family; Region: Phage_capsid; cl19393
216389000921	Terminase-like family; Region: Terminase_6; pfam03237
216389000922	Uncharacterized conserved protein [Function unknown]; Region: COG5484
216389000923	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
216389000924	Putative zinc ribbon domain; Region: DUF164; pfam02591
216389000925	Domain of unknown function (DUF4328); Region: DUF4328; pfam14219
216389000926	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
216389000927	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
216389000928	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
216389000929	protein binding site [polypeptide binding]; other site
216389000930	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
216389000931	Catalytic dyad [active]
216389000932	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
216389000933	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
216389000934	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
216389000935	dimer interface [polypeptide binding]; other site
216389000936	motif 1; other site
216389000937	active site
216389000938	motif 2; other site
216389000939	motif 3; other site
216389000940	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
216389000941	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
216389000942	putative tRNA-binding site [nucleotide binding]; other site
216389000943	B3/4 domain; Region: B3_4; pfam03483
216389000944	tRNA synthetase B5 domain; Region: B5; pfam03484
216389000945	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
216389000946	dimer interface [polypeptide binding]; other site
216389000947	motif 1; other site
216389000948	motif 3; other site
216389000949	motif 2; other site
216389000950	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
216389000951	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
216389000952	dimer interface [polypeptide binding]; other site
216389000953	substrate binding site [chemical binding]; other site
216389000954	metal binding sites [ion binding]; metal-binding site
216389000955	prolyl-tRNA synthetase; Provisional; Region: PRK09194
216389000956	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
216389000957	dimer interface [polypeptide binding]; other site
216389000958	motif 1; other site
216389000959	active site
216389000960	motif 2; other site
216389000961	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
216389000962	putative deacylase active site [active]
216389000963	motif 3; other site
216389000964	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
216389000965	anticodon binding site; other site
216389000966	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
216389000967	1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612
216389000968	RIP metalloprotease RseP; Region: TIGR00054
216389000969	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
216389000970	active site
216389000971	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
216389000972	protein binding site [polypeptide binding]; other site
216389000973	putative substrate binding region [chemical binding]; other site
216389000974	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
216389000975	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
216389000976	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
216389000977	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
216389000978	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
216389000979	Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475
216389000980	active site
216389000981	dimer interface [polypeptide binding]; other site
216389000982	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
216389000983	hinge region; other site
216389000984	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
216389000985	putative nucleotide binding site [chemical binding]; other site
216389000986	uridine monophosphate binding site [chemical binding]; other site
216389000987	homohexameric interface [polypeptide binding]; other site
216389000988	elongation factor Ts; Reviewed; Region: tsf; PRK12332
216389000989	UBA/TS-N domain; Region: UBA; pfam00627
216389000990	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
216389000991	rRNA interaction site [nucleotide binding]; other site
216389000992	S8 interaction site; other site
216389000993	putative laminin-1 binding site; other site
216389000994	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
216389000995	putative active site [active]
216389000996	catalytic triad [active]
216389000997	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789
216389000998	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789
216389000999	Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046
216389001000	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
216389001001	dimerization interface [polypeptide binding]; other site
216389001002	ATP binding site [chemical binding]; other site
216389001003	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
216389001004	dimerization interface [polypeptide binding]; other site
216389001005	ATP binding site [chemical binding]; other site
216389001006	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
216389001007	active site
216389001008	multimer interface [polypeptide binding]; other site
216389001009	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
216389001010	iron-sulfur cluster [ion binding]; other site
216389001011	[2Fe-2S] cluster binding site [ion binding]; other site
216389001012	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
216389001013	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
216389001014	active site
216389001015	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
216389001016	putative SAM binding site [chemical binding]; other site
216389001017	putative homodimer interface [polypeptide binding]; other site
216389001018	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
216389001019	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
216389001020	active site
216389001021	HIGH motif; other site
216389001022	KMSKS motif; other site
216389001023	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
216389001024	tRNA binding surface [nucleotide binding]; other site
216389001025	anticodon binding site; other site
216389001026	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
216389001027	substrate binding pocket [chemical binding]; other site
216389001028	chain length determination region; other site
216389001029	substrate-Mg2+ binding site; other site
216389001030	catalytic residues [active]
216389001031	aspartate-rich region 1; other site
216389001032	active site lid residues [active]
216389001033	aspartate-rich region 2; other site
216389001034	FtsH Extracellular; Region: FtsH_ext; pfam06480
216389001035	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
216389001036	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216389001037	Walker A motif; other site
216389001038	ATP binding site [chemical binding]; other site
216389001039	Walker B motif; other site
216389001040	arginine finger; other site
216389001041	Peptidase family M41; Region: Peptidase_M41; pfam01434
216389001042	Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648
216389001043	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
216389001044	AP (apurinic/apyrimidinic) site pocket; other site
216389001045	DNA interaction; other site
216389001046	Metal-binding active site; metal-binding site
216389001047	Oligomerisation domain; Region: Oligomerisation; pfam02410
216389001048	Nucleoside diphosphate kinase; Region: NDK; pfam00334
216389001049	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
216389001050	active site
216389001051	multimer interface [polypeptide binding]; other site
216389001052	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
216389001053	Glycoprotease family; Region: Peptidase_M22; pfam00814
216389001054	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
216389001055	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216389001056	motif II; other site
216389001057	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
216389001058	thiamine monophosphate kinase; Provisional; Region: PRK05731
216389001059	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
216389001060	ATP binding site [chemical binding]; other site
216389001061	dimerization interface [polypeptide binding]; other site
216389001062	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
216389001063	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216389001064	S-adenosylmethionine binding site [chemical binding]; other site
216389001065	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
216389001066	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216389001067	S-adenosylmethionine binding site [chemical binding]; other site
216389001068	2-deoxy-scyllo-inosose synthase (DOIS) catalyzes carbocycle formation from D-glucose-6-phosphate to 2-deoxy-scyllo-inosose through a multistep reaction in the biosynthesis of aminoglycoside antibiotics; Region: DOIS; cd08197
216389001069	active site
216389001070	dimer interface [polypeptide binding]; other site
216389001071	metal binding site [ion binding]; metal-binding site
216389001072	1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962
216389001073	putative active site [active]
216389001074	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
216389001075	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216389001076	S-adenosylmethionine binding site [chemical binding]; other site
216389001077	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
216389001078	active site
216389001079	metal binding site [ion binding]; metal-binding site
216389001080	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216389001081	S-adenosylmethionine binding site [chemical binding]; other site
216389001082	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
216389001083	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
216389001084	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
216389001085	Rubrerythrin [Energy production and conversion]; Region: COG1592
216389001086	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
216389001087	binuclear metal center [ion binding]; other site
216389001088	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350
216389001089	iron binding site [ion binding]; other site
216389001090	Ion transport protein; Region: Ion_trans; pfam00520
216389001091	Ion channel; Region: Ion_trans_2; pfam07885
216389001092	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
216389001093	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
216389001094	active site
216389001095	NTP binding site [chemical binding]; other site
216389001096	metal binding triad [ion binding]; metal-binding site
216389001097	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
216389001098	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
216389001099	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216389001100	Walker A/P-loop; other site
216389001101	ATP binding site [chemical binding]; other site
216389001102	Q-loop/lid; other site
216389001103	ABC transporter signature motif; other site
216389001104	Walker B; other site
216389001105	D-loop; other site
216389001106	H-loop/switch region; other site
216389001107	ABC-2 type transporter; Region: ABC2_membrane; cl17235
216389001108	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
216389001109	hypothetical protein; Provisional; Region: PRK01184
216389001110	AAA domain; Region: AAA_18; pfam13238
216389001111	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
216389001112	catalytic motif [active]
216389001113	Zn binding site [ion binding]; other site
216389001114	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
216389001115	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
216389001116	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
216389001117	trimer interface [polypeptide binding]; other site
216389001118	active site
216389001119	Probable zinc-binding domain; Region: zf-trcl; pfam13451
216389001120	CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272
216389001121	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
216389001122	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
216389001123	Walker A/P-loop; other site
216389001124	ATP binding site [chemical binding]; other site
216389001125	Q-loop/lid; other site
216389001126	ABC transporter signature motif; other site
216389001127	Walker B; other site
216389001128	D-loop; other site
216389001129	H-loop/switch region; other site
216389001130	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
216389001131	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216389001132	dimer interface [polypeptide binding]; other site
216389001133	conserved gate region; other site
216389001134	putative PBP binding loops; other site
216389001135	ABC-ATPase subunit interface; other site
216389001136	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216389001137	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
216389001138	substrate binding pocket [chemical binding]; other site
216389001139	membrane-bound complex binding site; other site
216389001140	hinge residues; other site
216389001141	EDD domain protein, DegV family; Region: DegV; TIGR00762
216389001142	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
216389001143	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
216389001144	oligomer interface [polypeptide binding]; other site
216389001145	metal binding site [ion binding]; metal-binding site
216389001146	metal binding site [ion binding]; metal-binding site
216389001147	putative Cl binding site [ion binding]; other site
216389001148	aspartate ring; other site
216389001149	basic sphincter; other site
216389001150	hydrophobic gate; other site
216389001151	periplasmic entrance; other site
216389001152	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
216389001153	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
216389001154	Mut7-C RNAse domain; Region: Mut7-C; pfam01927
216389001155	putative carbohydrate kinase; Provisional; Region: PRK10565
216389001156	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
216389001157	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
216389001158	putative substrate binding site [chemical binding]; other site
216389001159	putative ATP binding site [chemical binding]; other site
216389001160	pantothenate kinase; Reviewed; Region: PRK13321
216389001161	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
216389001162	Flavoprotein; Region: Flavoprotein; pfam02441
216389001163	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
216389001164	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
216389001165	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
216389001166	active site
216389001167	HIGH motif; other site
216389001168	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
216389001169	KMSKS motif; other site
216389001170	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
216389001171	tRNA binding surface [nucleotide binding]; other site
216389001172	anticodon binding site; other site
216389001173	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
216389001174	PAS domain S-box; Region: sensory_box; TIGR00229
216389001175	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216389001176	putative active site [active]
216389001177	heme pocket [chemical binding]; other site
216389001178	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
216389001179	Histidine kinase; Region: HisKA_3; pfam07730
216389001180	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216389001181	ATP binding site [chemical binding]; other site
216389001182	Mg2+ binding site [ion binding]; other site
216389001183	G-X-G motif; other site
216389001184	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
216389001185	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216389001186	active site
216389001187	phosphorylation site [posttranslational modification]
216389001188	intermolecular recognition site; other site
216389001189	dimerization interface [polypeptide binding]; other site
216389001190	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216389001191	DNA binding residues [nucleotide binding]
216389001192	dimerization interface [polypeptide binding]; other site
216389001193	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
216389001194	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
216389001195	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216389001196	nucleotide binding region [chemical binding]; other site
216389001197	ATP-binding site [chemical binding]; other site
216389001198	SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516
216389001199	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
216389001200	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
216389001201	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
216389001202	active site
216389001203	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
216389001204	dimer interface [polypeptide binding]; other site
216389001205	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
216389001206	active site
216389001207	glycine-pyridoxal phosphate binding site [chemical binding]; other site
216389001208	folate binding site [chemical binding]; other site
216389001209	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
216389001210	Fe-S cluster binding site [ion binding]; other site
216389001211	active site
216389001212	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
216389001213	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
216389001214	RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521
216389001215	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
216389001216	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
216389001217	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
216389001218	excinuclease ABC subunit B; Provisional; Region: PRK05298
216389001219	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
216389001220	ATP binding site [chemical binding]; other site
216389001221	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216389001222	nucleotide binding region [chemical binding]; other site
216389001223	ATP-binding site [chemical binding]; other site
216389001224	Ultra-violet resistance protein B; Region: UvrB; pfam12344
216389001225	UvrB/uvrC motif; Region: UVR; pfam02151
216389001226	Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14605
216389001227	RuvA N terminal domain; Region: RuvA_N; pfam01330
216389001228	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
216389001229	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
216389001230	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
216389001231	active site
216389001232	putative DNA-binding cleft [nucleotide binding]; other site
216389001233	dimer interface [polypeptide binding]; other site
216389001234	hypothetical protein; Validated; Region: PRK00110
216389001235	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
216389001236	Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257
216389001237	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
216389001238	putative dimer interface [polypeptide binding]; other site
216389001239	[2Fe-2S] cluster binding site [ion binding]; other site
216389001240	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
216389001241	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172
216389001242	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172
216389001243	Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835
216389001244	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
216389001245	substrate binding site [chemical binding]; other site
216389001246	ligand binding site [chemical binding]; other site
216389001247	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
216389001248	substrate binding site [chemical binding]; other site
216389001249	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
216389001250	malate dehydrogenase; Reviewed; Region: PRK06223
216389001251	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
216389001252	NAD(P) binding site [chemical binding]; other site
216389001253	dimer interface [polypeptide binding]; other site
216389001254	tetramer (dimer of dimers) interface [polypeptide binding]; other site
216389001255	substrate binding site [chemical binding]; other site
216389001256	fumarate hydratase; Provisional; Region: PRK06246
216389001257	Fumarase C-terminus; Region: Fumerase_C; cl00795
216389001258	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
216389001259	nucleotide binding site/active site [active]
216389001260	catalytic residue [active]
216389001261	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
216389001262	dimer interface [polypeptide binding]; other site
216389001263	ADP-ribose binding site [chemical binding]; other site
216389001264	active site
216389001265	nudix motif; other site
216389001266	metal binding site [ion binding]; metal-binding site
216389001267	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216389001268	Coenzyme A binding pocket [chemical binding]; other site
216389001269	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
216389001270	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
216389001271	arogenate dehydrogenase; Region: PLN02256
216389001272	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
216389001273	Chorismate mutase type II; Region: CM_2; smart00830
216389001274	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
216389001275	Prephenate dehydratase; Region: PDT; pfam00800
216389001276	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
216389001277	putative L-Phe binding site [chemical binding]; other site
216389001278	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
216389001279	Tetramer interface [polypeptide binding]; other site
216389001280	active site
216389001281	FMN-binding site [chemical binding]; other site
216389001282	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
216389001283	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
216389001284	hinge; other site
216389001285	active site
216389001286	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
216389001287	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
216389001288	ADP binding site [chemical binding]; other site
216389001289	magnesium binding site [ion binding]; other site
216389001290	putative shikimate binding site; other site
216389001291	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
216389001292	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
216389001293	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
216389001294	shikimate binding site; other site
216389001295	NAD(P) binding site [chemical binding]; other site
216389001296	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
216389001297	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
216389001298	active site
216389001299	catalytic residue [active]
216389001300	dimer interface [polypeptide binding]; other site
216389001301	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
216389001302	active site
216389001303	dimer interface [polypeptide binding]; other site
216389001304	metal binding site [ion binding]; metal-binding site
216389001305	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
216389001306	DAHP synthetase I family; Region: DAHP_synth_1; cl17225
216389001307	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
216389001308	S17 interaction site [polypeptide binding]; other site
216389001309	S8 interaction site; other site
216389001310	16S rRNA interaction site [nucleotide binding]; other site
216389001311	streptomycin interaction site [chemical binding]; other site
216389001312	23S rRNA interaction site [nucleotide binding]; other site
216389001313	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
216389001314	30S ribosomal protein S7; Validated; Region: PRK05302
216389001315	elongation factor G; Reviewed; Region: PRK12739
216389001316	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
216389001317	G1 box; other site
216389001318	putative GEF interaction site [polypeptide binding]; other site
216389001319	GTP/Mg2+ binding site [chemical binding]; other site
216389001320	Switch I region; other site
216389001321	G2 box; other site
216389001322	G3 box; other site
216389001323	Switch II region; other site
216389001324	G4 box; other site
216389001325	G5 box; other site
216389001326	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
216389001327	Elongation Factor G, domain II; Region: EFG_II; pfam14492
216389001328	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
216389001329	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
216389001330	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
216389001331	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
216389001332	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
216389001333	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
216389001334	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
216389001335	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
216389001336	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
216389001337	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
216389001338	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
216389001339	putative translocon binding site; other site
216389001340	protein-rRNA interface [nucleotide binding]; other site
216389001341	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
216389001342	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
216389001343	G-X-X-G motif; other site
216389001344	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
216389001345	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
216389001346	23S rRNA interface [nucleotide binding]; other site
216389001347	5S rRNA interface [nucleotide binding]; other site
216389001348	putative antibiotic binding site [chemical binding]; other site
216389001349	L25 interface [polypeptide binding]; other site
216389001350	L27 interface [polypeptide binding]; other site
216389001351	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
216389001352	23S rRNA interface [nucleotide binding]; other site
216389001353	putative translocon interaction site; other site
216389001354	signal recognition particle (SRP54) interaction site; other site
216389001355	L23 interface [polypeptide binding]; other site
216389001356	trigger factor interaction site; other site
216389001357	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
216389001358	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
216389001359	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
216389001360	RNA binding site [nucleotide binding]; other site
216389001361	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
216389001362	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
216389001363	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
216389001364	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
216389001365	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
216389001366	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
216389001367	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
216389001368	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
216389001369	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
216389001370	5S rRNA interface [nucleotide binding]; other site
216389001371	L27 interface [polypeptide binding]; other site
216389001372	23S rRNA interface [nucleotide binding]; other site
216389001373	L5 interface [polypeptide binding]; other site
216389001374	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
216389001375	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
216389001376	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
216389001377	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
216389001378	23S rRNA binding site [nucleotide binding]; other site
216389001379	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
216389001380	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
216389001381	SecY translocase; Region: SecY; pfam00344
216389001382	adenylate kinase; Reviewed; Region: adk; PRK00279
216389001383	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
216389001384	AMP-binding site [chemical binding]; other site
216389001385	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
216389001386	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
216389001387	active site
216389001388	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
216389001389	rRNA binding site [nucleotide binding]; other site
216389001390	predicted 30S ribosome binding site; other site
216389001391	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
216389001392	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
216389001393	30S ribosomal protein S13; Region: bact_S13; TIGR03631
216389001394	30S ribosomal protein S11; Validated; Region: PRK05309
216389001395	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
216389001396	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
216389001397	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
216389001398	RNA binding surface [nucleotide binding]; other site
216389001399	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
216389001400	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
216389001401	alphaNTD - beta interaction site [polypeptide binding]; other site
216389001402	alphaNTD homodimer interface [polypeptide binding]; other site
216389001403	alphaNTD - beta' interaction site [polypeptide binding]; other site
216389001404	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
216389001405	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
216389001406	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
216389001407	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
216389001408	dimerization interface 3.5A [polypeptide binding]; other site
216389001409	active site
216389001410	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
216389001411	23S rRNA interface [nucleotide binding]; other site
216389001412	L3 interface [polypeptide binding]; other site
216389001413	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
216389001414	Domain of unknown function (DUF202); Region: DUF202; pfam02656
216389001415	bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674
216389001416	The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_1; cd05017
216389001417	dimer interface [polypeptide binding]; other site
216389001418	active site
216389001419	The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637
216389001420	dimer interface [polypeptide binding]; other site
216389001421	active site
216389001422	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
216389001423	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
216389001424	active site
216389001425	substrate binding site [chemical binding]; other site
216389001426	metal binding site [ion binding]; metal-binding site
216389001427	S-adenosylmethionine synthetase; Validated; Region: PRK05250
216389001428	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
216389001429	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
216389001430	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
216389001431	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
216389001432	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
216389001433	homotetramer interface [polypeptide binding]; other site
216389001434	ligand binding site [chemical binding]; other site
216389001435	catalytic site [active]
216389001436	NAD binding site [chemical binding]; other site
216389001437	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
216389001438	Predicted kinase [General function prediction only]; Region: COG0645
216389001439	AAA domain; Region: AAA_33; pfam13671
216389001440	CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310
216389001441	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
216389001442	Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005
216389001443	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182
216389001444	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
216389001445	ABC-2 type transporter; Region: ABC2_membrane; cl17235
216389001446	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216389001447	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
216389001448	Walker A/P-loop; other site
216389001449	ATP binding site [chemical binding]; other site
216389001450	Q-loop/lid; other site
216389001451	ABC transporter signature motif; other site
216389001452	Walker B; other site
216389001453	D-loop; other site
216389001454	H-loop/switch region; other site
216389001455	N-terminal half of MaoC dehydratase; Region: MaoC_dehydrat_N; pfam13452
216389001456	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
216389001457	active site
216389001458	catalytic site [active]
216389001459	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
216389001460	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
216389001461	HEAT repeats; Region: HEAT_2; pfam13646
216389001462	HEAT repeats; Region: HEAT_2; pfam13646
216389001463	HEAT repeats; Region: HEAT_2; pfam13646
216389001464	PAC2 family; Region: PAC2; pfam09754
216389001465	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
216389001466	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
216389001467	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
216389001468	This archaeal PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar...; Region: PGM_like1; cd03087
216389001469	active site
216389001470	substrate binding site [chemical binding]; other site
216389001471	metal binding site [ion binding]; metal-binding site
216389001472	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: Arch_glmU; TIGR03992
216389001473	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
216389001474	active site
216389001475	Substrate binding site; other site
216389001476	Mg++ binding site; other site
216389001477	Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636
216389001478	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: Arch_glmU; TIGR03992
216389001479	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
216389001480	active site
216389001481	Substrate binding site; other site
216389001482	Mg++ binding site; other site
216389001483	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
216389001484	putative trimer interface [polypeptide binding]; other site
216389001485	putative CoA binding site [chemical binding]; other site
216389001486	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
216389001487	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
216389001488	glutaminase active site [active]
216389001489	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
216389001490	dimer interface [polypeptide binding]; other site
216389001491	active site
216389001492	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
216389001493	dimer interface [polypeptide binding]; other site
216389001494	active site
216389001495	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
216389001496	substrate binding site [chemical binding]; other site
216389001497	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
216389001498	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216389001499	motif II; other site
216389001500	diaminopimelate decarboxylase; Region: lysA; TIGR01048
216389001501	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
216389001502	active site
216389001503	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
216389001504	substrate binding site [chemical binding]; other site
216389001505	catalytic residues [active]
216389001506	dimer interface [polypeptide binding]; other site
216389001507	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216389001508	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
216389001509	Walker A motif; other site
216389001510	ATP binding site [chemical binding]; other site
216389001511	Walker B motif; other site
216389001512	ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470
216389001513	arginine finger; other site
216389001514	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
216389001515	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
216389001516	active site
216389001517	hypothetical protein; Provisional; Region: PRK06921
216389001518	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216389001519	Walker A motif; other site
216389001520	ATP binding site [chemical binding]; other site
216389001521	Walker B motif; other site
216389001522	arginine finger; other site
216389001523	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216389001524	Walker A motif; other site
216389001525	ATP binding site [chemical binding]; other site
216389001526	Walker B motif; other site
216389001527	arginine finger; other site
216389001528	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
216389001529	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
216389001530	replicative DNA helicase; Region: DnaB; TIGR00665
216389001531	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
216389001532	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
216389001533	Walker A motif; other site
216389001534	ATP binding site [chemical binding]; other site
216389001535	Walker B motif; other site
216389001536	DNA binding loops [nucleotide binding]
216389001537	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
216389001538	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
216389001539	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
216389001540	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
216389001541	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
216389001542	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
216389001543	putative phosphate acyltransferase; Provisional; Region: PRK05331
216389001544	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
216389001545	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
216389001546	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
216389001547	metal binding site [ion binding]; metal-binding site
216389001548	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
216389001549	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
216389001550	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
216389001551	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
216389001552	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
216389001553	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216389001554	non-specific DNA binding site [nucleotide binding]; other site
216389001555	salt bridge; other site
216389001556	sequence-specific DNA binding site [nucleotide binding]; other site
216389001557	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
216389001558	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
216389001559	Walker A/P-loop; other site
216389001560	ATP binding site [chemical binding]; other site
216389001561	Q-loop/lid; other site
216389001562	TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325
216389001563	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
216389001564	ABC transporter signature motif; other site
216389001565	Walker B; other site
216389001566	D-loop; other site
216389001567	H-loop/switch region; other site
216389001568	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
216389001569	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
216389001570	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216389001571	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
216389001572	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
216389001573	DNA binding residues [nucleotide binding]
216389001574	DNA primase; Validated; Region: dnaG; PRK05667
216389001575	CHC2 zinc finger; Region: zf-CHC2; cl17510
216389001576	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
216389001577	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
216389001578	active site
216389001579	metal binding site [ion binding]; metal-binding site
216389001580	interdomain interaction site; other site
216389001581	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
216389001582	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
216389001583	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
216389001584	Zn2+ binding site [ion binding]; other site
216389001585	Mg2+ binding site [ion binding]; other site
216389001586	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
216389001587	phosphoenolpyruvate synthase; Validated; Region: PRK06464
216389001588	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
216389001589	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
216389001590	PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
216389001591	Bifunctional nuclease; Region: DNase-RNase; pfam02577
216389001592	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
216389001593	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
216389001594	F0F1 ATP synthase subunit C; Provisional; Region: PRK13469
216389001595	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
216389001596	F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192
216389001597	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429
216389001598	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
216389001599	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
216389001600	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
216389001601	beta subunit interaction interface [polypeptide binding]; other site
216389001602	Walker A motif; other site
216389001603	ATP binding site [chemical binding]; other site
216389001604	Walker B motif; other site
216389001605	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
216389001606	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
216389001607	core domain interface [polypeptide binding]; other site
216389001608	delta subunit interface [polypeptide binding]; other site
216389001609	epsilon subunit interface [polypeptide binding]; other site
216389001610	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
216389001611	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
216389001612	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
216389001613	alpha subunit interaction interface [polypeptide binding]; other site
216389001614	Walker A motif; other site
216389001615	ATP binding site [chemical binding]; other site
216389001616	Walker B motif; other site
216389001617	inhibitor binding site; inhibition site
216389001618	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
216389001619	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
216389001620	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
216389001621	gamma subunit interface [polypeptide binding]; other site
216389001622	epsilon subunit interface [polypeptide binding]; other site
216389001623	LBP interface [polypeptide binding]; other site
216389001624	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
216389001625	RimM N-terminal domain; Region: RimM; pfam01782
216389001626	PRC-barrel domain; Region: PRC; pfam05239
216389001627	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
216389001628	KH domain; Region: KH_4; pfam13083
216389001629	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
216389001630	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
216389001631	Active_site [active]
216389001632	peptide chain release factor 2; Validated; Region: prfB; PRK00578
216389001633	PCRF domain; Region: PCRF; pfam03462
216389001634	RF-1 domain; Region: RF-1; pfam00472
216389001635	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
216389001636	Zn binding site [ion binding]; other site
216389001637	hypothetical protein; Reviewed; Region: PRK00024
216389001638	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066
216389001639	helix-hairpin-helix signature motif; other site
216389001640	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
216389001641	MPN+ (JAMM) motif; other site
216389001642	substrate binding pocket [chemical binding]; other site
216389001643	Zinc-binding site [ion binding]; other site
216389001644	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
216389001645	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
216389001646	peptide binding site [polypeptide binding]; other site
216389001647	capreomycidine synthase; Region: viomycin_VioD; TIGR03947
216389001648	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216389001649	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216389001650	homodimer interface [polypeptide binding]; other site
216389001651	catalytic residue [active]
216389001652	seryl-tRNA synthetase; Provisional; Region: PRK05431
216389001653	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
216389001654	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
216389001655	dimer interface [polypeptide binding]; other site
216389001656	active site
216389001657	motif 1; other site
216389001658	motif 2; other site
216389001659	motif 3; other site
216389001660	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
216389001661	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
216389001662	dimer interface [polypeptide binding]; other site
216389001663	putative anticodon binding site; other site
216389001664	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
216389001665	motif 1; other site
216389001666	active site
216389001667	motif 2; other site
216389001668	motif 3; other site
216389001669	Recombination protein O N terminal; Region: RecO_N; pfam11967
216389001670	DNA repair protein RecO; Region: reco; TIGR00613
216389001671	Recombination protein O C terminal; Region: RecO_C; pfam02565
216389001672	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
216389001673	A new structural DNA glycosylase; Region: AlkD_like; cd06561
216389001674	active site
216389001675	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
216389001676	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
216389001677	oligomer interface [polypeptide binding]; other site
216389001678	metal binding site [ion binding]; metal-binding site
216389001679	metal binding site [ion binding]; metal-binding site
216389001680	Cl binding site [ion binding]; other site
216389001681	aspartate ring; other site
216389001682	basic sphincter; other site
216389001683	putative hydrophobic gate; other site
216389001684	periplasmic entrance; other site
216389001685	recombination protein RecR; Reviewed; Region: recR; PRK00076
216389001686	RecR protein; Region: RecR; pfam02132
216389001687	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
216389001688	putative active site [active]
216389001689	putative metal-binding site [ion binding]; other site
216389001690	tetramer interface [polypeptide binding]; other site
216389001691	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575
216389001692	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950
216389001693	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216389001694	Walker A motif; other site
216389001695	ATP binding site [chemical binding]; other site
216389001696	Walker B motif; other site
216389001697	arginine finger; other site
216389001698	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
216389001699	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
216389001700	Protein of unknown function (DUF2089); Region: DUF2089; pfam09862
216389001701	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type2; cd02202
216389001702	Tubulin/FtsZ family, GTPase domain; Region: Tubulin; pfam00091
216389001703	nucleotide binding site [chemical binding]; other site
216389001704	SulA interaction site; other site
216389001705	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
216389001706	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
216389001707	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
216389001708	Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775
216389001709	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
216389001710	enolase; Provisional; Region: eno; PRK00077
216389001711	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
216389001712	dimer interface [polypeptide binding]; other site
216389001713	metal binding site [ion binding]; metal-binding site
216389001714	substrate binding pocket [chemical binding]; other site
216389001715	DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695
216389001716	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
216389001717	putative active site [active]
216389001718	catalytic residue [active]
216389001719	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
216389001720	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
216389001721	nucleotide binding pocket [chemical binding]; other site
216389001722	K-X-D-G motif; other site
216389001723	catalytic site [active]
216389001724	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
216389001725	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
216389001726	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
216389001727	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
216389001728	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
216389001729	Dimer interface [polypeptide binding]; other site
216389001730	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
216389001731	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
216389001732	predicted active site [active]
216389001733	catalytic triad [active]
216389001734	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
216389001735	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
216389001736	ligand binding site [chemical binding]; other site
216389001737	NAD binding site [chemical binding]; other site
216389001738	dimerization interface [polypeptide binding]; other site
216389001739	catalytic site [active]
216389001740	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
216389001741	putative L-serine binding site [chemical binding]; other site
216389001742	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
216389001743	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
216389001744	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
216389001745	catalytic residue [active]
216389001746	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
216389001747	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
216389001748	active site
216389001749	HIGH motif; other site
216389001750	dimer interface [polypeptide binding]; other site
216389001751	KMSKS motif; other site
216389001752	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
216389001753	RNA binding surface [nucleotide binding]; other site
216389001754	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
216389001755	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
216389001756	active site
216389001757	Riboflavin kinase; Region: Flavokinase; pfam01687
216389001758	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
216389001759	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
216389001760	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
216389001761	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
216389001762	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
216389001763	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
216389001764	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
216389001765	RPB10 interaction site [polypeptide binding]; other site
216389001766	RPB11 interaction site [polypeptide binding]; other site
216389001767	RPB3 interaction site [polypeptide binding]; other site
216389001768	RPB12 interaction site [polypeptide binding]; other site
216389001769	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
216389001770	RPB1 interaction site [polypeptide binding]; other site
216389001771	Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609
216389001772	beta and beta' interface [polypeptide binding]; other site
216389001773	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
216389001774	beta' and sigma factor interface [polypeptide binding]; other site
216389001775	Zn-binding [ion binding]; other site
216389001776	active site region [active]
216389001777	catalytic site [active]
216389001778	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
216389001779	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
216389001780	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
216389001781	G-loop; other site
216389001782	DNA binding site [nucleotide binding]
216389001783	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
216389001784	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
216389001785	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216389001786	Walker A motif; other site
216389001787	ATP binding site [chemical binding]; other site
216389001788	Walker B motif; other site
216389001789	arginine finger; other site
216389001790	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
216389001791	Uncharacterized BCR, COG1636; Region: DUF208; pfam02677
216389001792	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
216389001793	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216389001794	Coenzyme A binding pocket [chemical binding]; other site
216389001795	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
216389001796	Predicted permease; Region: DUF318; cl17795
216389001797	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216389001798	S-adenosylmethionine binding site [chemical binding]; other site
216389001799	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216389001800	FeS/SAM binding site; other site
216389001801	Radical SAM superfamily; Region: Radical_SAM; pfam04055
216389001802	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
216389001803	Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941
216389001804	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
216389001805	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
216389001806	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
216389001807	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
216389001808	Endopeptidases belonging to F420-reducing hydrogenases group. These hydrogenases from methanogens are encoded by the fru, frc, or frh genes. Sequence comparison indicates that fruD and frcD gene products from Methanococcus voltae are similar to HycI...; Region: H2MP_F420-Reduc; cd06064
216389001809	nickel binding site [ion binding]; other site
216389001810	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
216389001811	catalytic residues [active]
216389001812	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
216389001813	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
216389001814	Putative small multi-drug export protein; Region: Sm_multidrug_ex; cl01024
216389001815	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216389001816	FeS/SAM binding site; other site
216389001817	Radical SAM superfamily; Region: Radical_SAM; pfam04055
216389001818	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
216389001819	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
216389001820	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
216389001821	active site
216389001822	effector binding site; other site
216389001823	dimer interface [polypeptide binding]; other site
216389001824	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
216389001825	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216389001826	active site
216389001827	phosphorylation site [posttranslational modification]
216389001828	intermolecular recognition site; other site
216389001829	dimerization interface [polypeptide binding]; other site
216389001830	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
216389001831	Zn2+ binding site [ion binding]; other site
216389001832	Mg2+ binding site [ion binding]; other site
216389001833	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
216389001834	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216389001835	putative active site [active]
216389001836	heme pocket [chemical binding]; other site
216389001837	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216389001838	putative active site [active]
216389001839	heme pocket [chemical binding]; other site
216389001840	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
216389001841	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
216389001842	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216389001843	putative active site [active]
216389001844	heme pocket [chemical binding]; other site
216389001845	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216389001846	dimer interface [polypeptide binding]; other site
216389001847	phosphorylation site [posttranslational modification]
216389001848	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216389001849	ATP binding site [chemical binding]; other site
216389001850	Mg2+ binding site [ion binding]; other site
216389001851	G-X-G motif; other site
216389001852	Putative zinc- or iron-chelating domain; Region: CxxCxxCC; pfam03692
216389001853	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
216389001854	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216389001855	FeS/SAM binding site; other site
216389001856	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
216389001857	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
216389001858	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
216389001859	ATP-grasp domain; Region: ATP-grasp_4; cl17255
216389001860	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
216389001861	metal binding site 2 [ion binding]; metal-binding site
216389001862	putative DNA binding helix; other site
216389001863	metal binding site 1 [ion binding]; metal-binding site
216389001864	dimer interface [polypeptide binding]; other site
216389001865	structural Zn2+ binding site [ion binding]; other site
216389001866	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
216389001867	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
216389001868	intersubunit interface [polypeptide binding]; other site
216389001869	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
216389001870	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
216389001871	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
216389001872	ABC-ATPase subunit  interface; other site
216389001873	dimer interface [polypeptide binding]; other site
216389001874	putative PBP binding regions; other site
216389001875	cell division protein FtsZ; Validated; Region: PRK09330
216389001876	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
216389001877	nucleotide binding site [chemical binding]; other site
216389001878	SulA interaction site; other site
216389001879	cell division protein FtsA; Region: ftsA; TIGR01174
216389001880	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
216389001881	nucleotide binding site [chemical binding]; other site
216389001882	SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491
216389001883	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
216389001884	Cell division protein FtsA; Region: FtsA; pfam14450
216389001885	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
216389001886	Ligand Binding Site [chemical binding]; other site
216389001887	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
216389001888	Ligand Binding Site [chemical binding]; other site
216389001889	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
216389001890	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
216389001891	substrate binding site [chemical binding]; other site
216389001892	hexamer interface [polypeptide binding]; other site
216389001893	metal binding site [ion binding]; metal-binding site
216389001894	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
216389001895	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
216389001896	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
216389001897	TPP-binding site [chemical binding]; other site
216389001898	dimer interface [polypeptide binding]; other site
216389001899	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
216389001900	PYR/PP interface [polypeptide binding]; other site
216389001901	dimer interface [polypeptide binding]; other site
216389001902	TPP binding site [chemical binding]; other site
216389001903	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
216389001904	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
216389001905	putative FMN binding site [chemical binding]; other site
216389001906	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
216389001907	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216389001908	S-adenosylmethionine binding site [chemical binding]; other site
216389001909	DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695
216389001910	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
216389001911	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
216389001912	cobalamin binding residues [chemical binding]; other site
216389001913	putative BtuC binding residues; other site
216389001914	dimer interface [polypeptide binding]; other site
216389001915	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
216389001916	ABC-ATPase subunit  interface; other site
216389001917	dimer interface [polypeptide binding]; other site
216389001918	putative PBP binding regions; other site
216389001919	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
216389001920	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
216389001921	Walker A/P-loop; other site
216389001922	ATP binding site [chemical binding]; other site
216389001923	Q-loop/lid; other site
216389001924	ABC transporter signature motif; other site
216389001925	Walker B; other site
216389001926	D-loop; other site
216389001927	H-loop/switch region; other site
216389001928	Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955
216389001929	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
216389001930	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
216389001931	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216389001932	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216389001933	homodimer interface [polypeptide binding]; other site
216389001934	catalytic residue [active]
216389001935	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
216389001936	putative dimer interface [polypeptide binding]; other site
216389001937	active site pocket [active]
216389001938	putative cataytic base [active]
216389001939	cobalamin synthase; Reviewed; Region: cobS; PRK00235
216389001940	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
216389001941	catalytic core [active]
216389001942	Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; pfam02283
216389001943	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
216389001944	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
216389001945	catalytic residues [active]
216389001946	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
216389001947	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
216389001948	Histidine kinase; Region: HisKA_3; pfam07730
216389001949	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216389001950	ATP binding site [chemical binding]; other site
216389001951	Mg2+ binding site [ion binding]; other site
216389001952	G-X-G motif; other site
216389001953	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
216389001954	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216389001955	active site
216389001956	phosphorylation site [posttranslational modification]
216389001957	intermolecular recognition site; other site
216389001958	dimerization interface [polypeptide binding]; other site
216389001959	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216389001960	DNA binding residues [nucleotide binding]
216389001961	dimerization interface [polypeptide binding]; other site
216389001962	Domain of unknown function (DUF3786); Region: DUF3786; pfam12654
216389001963	acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional; Region: PRK04165
216389001964	Putative Fe-S cluster; Region: FeS; pfam04060
216389001965	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
216389001966	bifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta; Reviewed; Region: PRK09529
216389001967	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
216389001968	ACS interaction site; other site
216389001969	CODH interaction site; other site
216389001970	metal cluster binding site [ion binding]; other site
216389001971	CO dehydrogenase/acetyl-CoA synthase complex beta subunit; Region: CdhC; pfam03598
216389001972	acetyl-CoA decarbonylase/synthase complex subunit delta; Provisional; Region: PRK04452
216389001973	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190
216389001974	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
216389001975	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
216389001976	homodimer interface [polypeptide binding]; other site
216389001977	NADP binding site [chemical binding]; other site
216389001978	substrate binding site [chemical binding]; other site
216389001979	CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640
216389001980	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
216389001981	P-loop; other site
216389001982	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
216389001983	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
216389001984	catalytic loop [active]
216389001985	iron binding site [ion binding]; other site
216389001986	Domain of unknown function (DUF4445); Region: DUF4445; pfam14574
216389001987	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
216389001988	Potassium binding sites [ion binding]; other site
216389001989	Cesium cation binding sites [ion binding]; other site
216389001990	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
216389001991	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
216389001992	dimer interface [polypeptide binding]; other site
216389001993	anticodon binding site; other site
216389001994	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
216389001995	homodimer interface [polypeptide binding]; other site
216389001996	motif 1; other site
216389001997	active site
216389001998	motif 2; other site
216389001999	GAD domain; Region: GAD; pfam02938
216389002000	motif 3; other site
216389002001	Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697
216389002002	trigger factor; Region: tig; TIGR00115
216389002003	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
216389002004	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
216389002005	oligomer interface [polypeptide binding]; other site
216389002006	active site residues [active]
216389002007	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
216389002008	substrate binding site [chemical binding]; other site
216389002009	ATP binding site [chemical binding]; other site
216389002010	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
216389002011	substrate binding site [chemical binding]; other site
216389002012	active site
216389002013	cosubstrate binding site; other site
216389002014	catalytic site [active]
216389002015	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
216389002016	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
216389002017	active site
216389002018	PHP-associated; Region: PHP_C; pfam13263
216389002019	translation elongation factor P; Region: efp; TIGR00038
216389002020	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
216389002021	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
216389002022	RNA binding site [nucleotide binding]; other site
216389002023	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
216389002024	RNA binding site [nucleotide binding]; other site
216389002025	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
216389002026	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
216389002027	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
216389002028	active site
216389002029	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
216389002030	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
216389002031	active site
216389002032	Int/Topo IB signature motif; other site
216389002033	DNA topoisomerase I; Validated; Region: PRK05582
216389002034	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
216389002035	active site
216389002036	interdomain interaction site; other site
216389002037	putative metal-binding site [ion binding]; other site
216389002038	nucleotide binding site [chemical binding]; other site
216389002039	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
216389002040	domain I; other site
216389002041	DNA binding groove [nucleotide binding]
216389002042	phosphate binding site [ion binding]; other site
216389002043	domain II; other site
216389002044	domain III; other site
216389002045	nucleotide binding site [chemical binding]; other site
216389002046	catalytic site [active]
216389002047	domain IV; other site
216389002048	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
216389002049	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
216389002050	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
216389002051	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
216389002052	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
216389002053	pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029
216389002054	2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; Region: PorC_KorC; TIGR02175
216389002055	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
216389002056	2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179
216389002057	pyruvate ferredoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK08367
216389002058	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
216389002059	dimer interface [polypeptide binding]; other site
216389002060	PYR/PP interface [polypeptide binding]; other site
216389002061	TPP binding site [chemical binding]; other site
216389002062	substrate binding site [chemical binding]; other site
216389002063	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
216389002064	pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865
216389002065	Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376
216389002066	TPP-binding site [chemical binding]; other site
216389002067	putative dimer interface [polypeptide binding]; other site
216389002068	Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257
216389002069	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
216389002070	putative dimer interface [polypeptide binding]; other site
216389002071	[2Fe-2S] cluster binding site [ion binding]; other site
216389002072	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
216389002073	dimer interface [polypeptide binding]; other site
216389002074	[2Fe-2S] cluster binding site [ion binding]; other site
216389002075	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
216389002076	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
216389002077	SLBB domain; Region: SLBB; pfam10531
216389002078	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
216389002079	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
216389002080	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
216389002081	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
216389002082	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321
216389002083	Moco binding site; other site
216389002084	metal coordination site [ion binding]; other site
216389002085	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
216389002086	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
216389002087	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
216389002088	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
216389002089	Zinc ribbon domain; Region: Zn-ribbon_8; pfam09723
216389002090	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
216389002091	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216389002092	NAD(P) binding site [chemical binding]; other site
216389002093	active site
216389002094	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
216389002095	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
216389002096	HflX GTPase family; Region: HflX; cd01878
216389002097	G1 box; other site
216389002098	GTP/Mg2+ binding site [chemical binding]; other site
216389002099	Switch I region; other site
216389002100	G2 box; other site
216389002101	G3 box; other site
216389002102	Switch II region; other site
216389002103	G4 box; other site
216389002104	G5 box; other site
216389002105	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
216389002106	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216389002107	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216389002108	homodimer interface [polypeptide binding]; other site
216389002109	catalytic residue [active]
216389002110	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
216389002111	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
216389002112	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
216389002113	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
216389002114	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
216389002115	substrate binding site [chemical binding]; other site
216389002116	dimer interface [polypeptide binding]; other site
216389002117	catalytic triad [active]
216389002118	cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04135
216389002119	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
216389002120	substrate binding site [chemical binding]; other site
216389002121	hinge regions; other site
216389002122	ADP binding site [chemical binding]; other site
216389002123	catalytic site [active]
216389002124	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
216389002125	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
216389002126	TPP-binding site; other site
216389002127	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
216389002128	PYR/PP interface [polypeptide binding]; other site
216389002129	dimer interface [polypeptide binding]; other site
216389002130	TPP binding site [chemical binding]; other site
216389002131	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
216389002132	Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695
216389002133	GAF domain; Region: GAF_2; pfam13185
216389002134	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
216389002135	active site
216389002136	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
216389002137	23S rRNA binding site [nucleotide binding]; other site
216389002138	L21 binding site [polypeptide binding]; other site
216389002139	L13 binding site [polypeptide binding]; other site
216389002140	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
216389002141	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
216389002142	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
216389002143	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
216389002144	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
216389002145	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
216389002146	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
216389002147	active site
216389002148	dimer interface [polypeptide binding]; other site
216389002149	motif 1; other site
216389002150	motif 2; other site
216389002151	motif 3; other site
216389002152	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
216389002153	anticodon binding site; other site
216389002154	MAEBL; Provisional; Region: PTZ00121
216389002155	MAEBL; Provisional; Region: PTZ00121
216389002156	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
216389002157	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
216389002158	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
216389002159	catalytic residue [active]
216389002160	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
216389002161	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
216389002162	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
216389002163	active site
216389002164	catalytic residues [active]
216389002165	metal binding site [ion binding]; metal-binding site
216389002166	Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945
216389002167	Putative lysophospholipase; Region: Hydrolase_4; cl19140
216389002168	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
216389002169	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
216389002170	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
216389002171	Predicted membrane protein [Function unknown]; Region: COG4818
216389002172	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
216389002173	Peptidase family M50; Region: Peptidase_M50; pfam02163
216389002174	active site
216389002175	putative substrate binding region [chemical binding]; other site
216389002176	FOG: CBS domain [General function prediction only]; Region: COG0517
216389002177	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50.  CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801
216389002178	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
216389002179	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
216389002180	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
216389002181	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
216389002182	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
216389002183	CAAX protease self-immunity; Region: Abi; pfam02517
216389002184	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
216389002185	Peptidase family M50; Region: Peptidase_M50; pfam02163
216389002186	active site
216389002187	putative substrate binding region [chemical binding]; other site
216389002188	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
216389002189	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
216389002190	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
216389002191	stage III sporulation protein AA; Region: spore_III_AA; TIGR02858
216389002192	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216389002193	Walker A motif; other site
216389002194	ATP binding site [chemical binding]; other site
216389002195	Walker B motif; other site
216389002196	R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645
216389002197	RxxxH motif; other site
216389002198	thymidylate kinase; Validated; Region: tmk; PRK00698
216389002199	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
216389002200	TMP-binding site; other site
216389002201	ATP-binding site [chemical binding]; other site
216389002202	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
216389002203	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
216389002204	Ligand Binding Site [chemical binding]; other site
216389002205	Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
216389002206	RNA/DNA hybrid binding site [nucleotide binding]; other site
216389002207	active site
216389002208	hypothetical protein; Provisional; Region: PRK14688
216389002209	thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615
216389002210	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
216389002211	thiamine phosphate binding site [chemical binding]; other site
216389002212	active site
216389002213	pyrophosphate binding site [ion binding]; other site
216389002214	haloacid dehalogenase superfamily protein; Provisional; Region: PRK14562
216389002215	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
216389002216	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
216389002217	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
216389002218	glycyl-tRNA synthetase; Provisional; Region: PRK04173
216389002219	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
216389002220	dimer interface [polypeptide binding]; other site
216389002221	motif 1; other site
216389002222	active site
216389002223	motif 2; other site
216389002224	motif 3; other site
216389002225	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
216389002226	anticodon binding site; other site
216389002227	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
216389002228	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
216389002229	active site
216389002230	metal binding site [ion binding]; metal-binding site
216389002231	DNA binding site [nucleotide binding]
216389002232	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
216389002233	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
216389002234	RNA binding surface [nucleotide binding]; other site
216389002235	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
216389002236	active site
216389002237	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
216389002238	active site
216389002239	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
216389002240	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
216389002241	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
216389002242	active site
216389002243	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
216389002244	active site
216389002245	putative protein serine/threonine phosphatase; Provisional; Region: PRK14559
216389002246	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
216389002247	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
216389002248	Walker A/P-loop; other site
216389002249	ATP binding site [chemical binding]; other site
216389002250	Q-loop/lid; other site
216389002251	ABC transporter signature motif; other site
216389002252	Walker B; other site
216389002253	D-loop; other site
216389002254	H-loop/switch region; other site
216389002255	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580
216389002256	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
216389002257	ABC-2 type transporter; Region: ABC2_membrane; cl17235
216389002258	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
216389002259	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
216389002260	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
216389002261	tRNA_anti-like; Region: tRNA_anti-like; pfam12869
216389002262	Uncharacterized conserved protein [Function unknown]; Region: COG5495
216389002263	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
216389002264	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
216389002265	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
216389002266	tetramerization interface [polypeptide binding]; other site
216389002267	active site
216389002268	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
216389002269	oligomerization interface [polypeptide binding]; other site
216389002270	active site
216389002271	metal binding site [ion binding]; metal-binding site
216389002272	Pantoate-beta-alanine ligase; Region: PanC; cd00560
216389002273	active site
216389002274	ATP-binding site [chemical binding]; other site
216389002275	pantoate-binding site; other site
216389002276	HXXH motif; other site
216389002277	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216389002278	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216389002279	putative substrate translocation pore; other site
216389002280	Transcriptional regulators [Transcription]; Region: MarR; COG1846
216389002281	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
216389002282	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
216389002283	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
216389002284	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
216389002285	Predicted membrane protein (DUF2070); Region: DUF2070; cl19221
216389002286	PAP2 superfamily; Region: PAP2; pfam01569
216389002287	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
216389002288	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216389002289	Walker A/P-loop; other site
216389002290	ATP binding site [chemical binding]; other site
216389002291	Q-loop/lid; other site
216389002292	ABC transporter signature motif; other site
216389002293	Walker B; other site
216389002294	D-loop; other site
216389002295	H-loop/switch region; other site
216389002296	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
216389002297	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
216389002298	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
216389002299	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
216389002300	Walker A/P-loop; other site
216389002301	ATP binding site [chemical binding]; other site
216389002302	Q-loop/lid; other site
216389002303	ABC transporter signature motif; other site
216389002304	Walker B; other site
216389002305	D-loop; other site
216389002306	H-loop/switch region; other site
216389002307	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
216389002308	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
216389002309	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
216389002310	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
216389002311	Walker A/P-loop; other site
216389002312	ATP binding site [chemical binding]; other site
216389002313	Q-loop/lid; other site
216389002314	ABC transporter signature motif; other site
216389002315	Walker B; other site
216389002316	D-loop; other site
216389002317	H-loop/switch region; other site
216389002318	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
216389002319	dimerization interface [polypeptide binding]; other site
216389002320	active site
216389002321	Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951
216389002322	Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690
216389002323	tRNA-splicing ligase RtcB; Region: RtcB; pfam01139
216389002324	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
216389002325	putative FMN binding site [chemical binding]; other site
216389002326	NADPH bind site [chemical binding]; other site
216389002327	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
216389002328	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
216389002329	active site
216389002330	catalytic residues [active]
216389002331	metal binding site [ion binding]; metal-binding site
216389002332	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
216389002333	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
216389002334	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
216389002335	substrate binding site [chemical binding]; other site
216389002336	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
216389002337	substrate binding site [chemical binding]; other site
216389002338	ligand binding site [chemical binding]; other site
216389002339	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
216389002340	MgtC family; Region: MgtC; pfam02308
216389002341	2-isopropylmalate synthase; Validated; Region: PRK00915
216389002342	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
216389002343	active site
216389002344	catalytic residues [active]
216389002345	metal binding site [ion binding]; metal-binding site
216389002346	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
216389002347	ketol-acid reductoisomerase; Provisional; Region: PRK05479
216389002348	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
216389002349	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
216389002350	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
216389002351	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
216389002352	putative valine binding site [chemical binding]; other site
216389002353	dimer interface [polypeptide binding]; other site
216389002354	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
216389002355	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
216389002356	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
216389002357	PYR/PP interface [polypeptide binding]; other site
216389002358	dimer interface [polypeptide binding]; other site
216389002359	TPP binding site [chemical binding]; other site
216389002360	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
216389002361	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
216389002362	TPP-binding site [chemical binding]; other site
216389002363	dimer interface [polypeptide binding]; other site
216389002364	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
216389002365	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
216389002366	GMP synthase; Reviewed; Region: guaA; PRK00074
216389002367	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
216389002368	AMP/PPi binding site [chemical binding]; other site
216389002369	candidate oxyanion hole; other site
216389002370	catalytic triad [active]
216389002371	potential glutamine specificity residues [chemical binding]; other site
216389002372	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
216389002373	ATP Binding subdomain [chemical binding]; other site
216389002374	Ligand Binding sites [chemical binding]; other site
216389002375	Dimerization subdomain; other site
216389002376	AIR carboxylase; Region: AIRC; pfam00731
216389002377	adenylosuccinate lyase; Provisional; Region: PRK07492
216389002378	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
216389002379	tetramer interface [polypeptide binding]; other site
216389002380	active site
216389002381	phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional; Region: PRK13959
216389002382	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
216389002383	active site
216389002384	ATP binding site [chemical binding]; other site
216389002385	substrate binding site [chemical binding]; other site
216389002386	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
216389002387	putative active site pocket [active]
216389002388	4-fold oligomerization interface [polypeptide binding]; other site
216389002389	metal binding residues [ion binding]; metal-binding site
216389002390	3-fold/trimer interface [polypeptide binding]; other site
216389002391	histidinol-phosphate aminotransferase; Provisional; Region: PLN03026
216389002392	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216389002393	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216389002394	homodimer interface [polypeptide binding]; other site
216389002395	catalytic residue [active]
216389002396	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
216389002397	histidinol dehydrogenase; Region: hisD; TIGR00069
216389002398	NAD binding site [chemical binding]; other site
216389002399	dimerization interface [polypeptide binding]; other site
216389002400	product binding site; other site
216389002401	substrate binding site [chemical binding]; other site
216389002402	zinc binding site [ion binding]; other site
216389002403	catalytic residues [active]
216389002404	ATP phosphoribosyltransferase; Region: HisG; cl15266
216389002405	ATP phosphoribosyltransferase; Region: HisG; cl15266
216389002406	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
216389002407	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
216389002408	dimer interface [polypeptide binding]; other site
216389002409	motif 1; other site
216389002410	active site
216389002411	motif 2; other site
216389002412	motif 3; other site
216389002413	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
216389002414	prohibitin homologues; Region: PHB; smart00244
216389002415	Uncharacterized prokaryotic subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_eoslipins_u1; cd08826
216389002416	trimer interface [polypeptide binding]; other site
216389002417	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
216389002418	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
216389002419	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
216389002420	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
216389002421	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
216389002422	ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269
216389002423	Walker A/P-loop; other site
216389002424	ATP binding site [chemical binding]; other site
216389002425	Q-loop/lid; other site
216389002426	ABC transporter signature motif; other site
216389002427	Walker B; other site
216389002428	D-loop; other site
216389002429	H-loop/switch region; other site
216389002430	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
216389002431	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
216389002432	Acyltransferase family; Region: Acyl_transf_3; cl19154
216389002433	threonine dehydratase; Reviewed; Region: PRK09224
216389002434	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
216389002435	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
216389002436	FtsX-like permease family; Region: FtsX; pfam02687
216389002437	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
216389002438	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
216389002439	Walker A/P-loop; other site
216389002440	ATP binding site [chemical binding]; other site
216389002441	Q-loop/lid; other site
216389002442	ABC transporter signature motif; other site
216389002443	Walker B; other site
216389002444	D-loop; other site
216389002445	H-loop/switch region; other site
216389002446	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
216389002447	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216389002448	FeS/SAM binding site; other site
216389002449	HemN C-terminal domain; Region: HemN_C; pfam06969
216389002450	GTP-binding protein LepA; Provisional; Region: PRK05433
216389002451	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
216389002452	G1 box; other site
216389002453	putative GEF interaction site [polypeptide binding]; other site
216389002454	GTP/Mg2+ binding site [chemical binding]; other site
216389002455	Switch I region; other site
216389002456	G2 box; other site
216389002457	G3 box; other site
216389002458	Switch II region; other site
216389002459	G4 box; other site
216389002460	G5 box; other site
216389002461	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
216389002462	Elongation Factor G, domain II; Region: EFG_II; pfam14492
216389002463	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
216389002464	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
216389002465	Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651
216389002466	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
216389002467	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
216389002468	NADH dehydrogenase; Region: NADHdh; cl00469
216389002469	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
216389002470	Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257
216389002471	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
216389002472	putative dimer interface [polypeptide binding]; other site
216389002473	[2Fe-2S] cluster binding site [ion binding]; other site
216389002474	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
216389002475	dimer interface [polypeptide binding]; other site
216389002476	[2Fe-2S] cluster binding site [ion binding]; other site
216389002477	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
216389002478	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
216389002479	SLBB domain; Region: SLBB; pfam10531
216389002480	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
216389002481	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
216389002482	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
216389002483	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
216389002484	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
216389002485	catalytic loop [active]
216389002486	iron binding site [ion binding]; other site
216389002487	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
216389002488	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
216389002489	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl19197
216389002490	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
216389002491	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
216389002492	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
216389002493	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
216389002494	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
216389002495	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
216389002496	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
216389002497	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
216389002498	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
216389002499	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
216389002500	motif 1; other site
216389002501	dimer interface [polypeptide binding]; other site
216389002502	active site
216389002503	motif 2; other site
216389002504	motif 3; other site
216389002505	elongation factor P; Validated; Region: PRK00529
216389002506	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
216389002507	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
216389002508	RNA binding site [nucleotide binding]; other site
216389002509	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
216389002510	RNA binding site [nucleotide binding]; other site
216389002511	Transcriptional regulators [Transcription]; Region: MarR; COG1846
216389002512	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
216389002513	Transport protein; Region: actII; TIGR00833
216389002514	MMPL family; Region: MMPL; cl14618
216389002515	MMPL family; Region: MMPL; cl14618
216389002516	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
216389002517	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216389002518	non-specific DNA binding site [nucleotide binding]; other site
216389002519	salt bridge; other site
216389002520	sequence-specific DNA binding site [nucleotide binding]; other site
216389002521	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
216389002522	Catalytic site [active]
216389002523	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
216389002524	putative Zn2+ binding site [ion binding]; other site
216389002525	putative DNA binding site [nucleotide binding]; other site
216389002526	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
216389002527	Citrate transporter; Region: CitMHS; pfam03600
216389002528	transmembrane helices; other site
216389002529	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216389002530	putative substrate translocation pore; other site
216389002531	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216389002532	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
216389002533	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
216389002534	active site
216389002535	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
216389002536	dinuclear metal binding motif [ion binding]; other site
216389002537	PAC2 family; Region: PAC2; pfam09754
216389002538	PAC2 family; Region: PAC2; pfam09754
216389002539	ATP-dependent DNA ligase; Provisional; Region: PRK01109
216389002540	hypothetical protein; Provisional; Region: PRK04334
216389002541	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
216389002542	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
216389002543	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
216389002544	Domain of unknown function DUF39; Region: DUF39; pfam01837
216389002545	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
216389002546	Walker A motif; other site
216389002547	ATP binding site [chemical binding]; other site
216389002548	Walker B motif; other site
216389002549	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
216389002550	NADH dehydrogenase subunit B; Validated; Region: PRK06411
216389002551	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl19197
216389002552	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
216389002553	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
216389002554	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
216389002555	Ferredoxin [Energy production and conversion]; Region: COG1146
216389002556	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
216389002557	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
216389002558	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
216389002559	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
216389002560	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
216389002561	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
216389002562	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
216389002563	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
216389002564	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
216389002565	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
216389002566	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
216389002567	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
216389002568	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
216389002569	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
216389002570	active site
216389002571	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
216389002572	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
216389002573	minor groove reading motif; other site
216389002574	helix-hairpin-helix signature motif; other site
216389002575	substrate binding pocket [chemical binding]; other site
216389002576	active site
216389002577	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
216389002578	cobyric acid synthase; Provisional; Region: PRK00784
216389002579	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
216389002580	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
216389002581	catalytic triad [active]
216389002582	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
216389002583	CoenzymeA binding site [chemical binding]; other site
216389002584	subunit interaction site [polypeptide binding]; other site
216389002585	PHB binding site; other site
216389002586	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
216389002587	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
216389002588	Walker A/P-loop; other site
216389002589	ATP binding site [chemical binding]; other site
216389002590	Q-loop/lid; other site
216389002591	ABC transporter signature motif; other site
216389002592	Walker B; other site
216389002593	D-loop; other site
216389002594	H-loop/switch region; other site
216389002595	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
216389002596	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
216389002597	acyl-activating enzyme (AAE) consensus motif; other site
216389002598	active site
216389002599	AMP binding site [chemical binding]; other site
216389002600	CoA binding site [chemical binding]; other site
216389002601	AMP-binding enzyme C-terminal domain; Region: AMP-binding_C; cl17063
216389002602	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
216389002603	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
216389002604	Walker A/P-loop; other site
216389002605	ATP binding site [chemical binding]; other site
216389002606	Q-loop/lid; other site
216389002607	ABC transporter signature motif; other site
216389002608	Walker B; other site
216389002609	D-loop; other site
216389002610	H-loop/switch region; other site
216389002611	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
216389002612	ligand binding site [chemical binding]; other site
216389002613	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
216389002614	ligand binding site [chemical binding]; other site
216389002615	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
216389002616	TM-ABC transporter signature motif; other site
216389002617	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
216389002618	TM-ABC transporter signature motif; other site
216389002619	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
216389002620	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
216389002621	acyl-activating enzyme (AAE) consensus motif; other site
216389002622	putative AMP binding site [chemical binding]; other site
216389002623	putative active site [active]
216389002624	putative CoA binding site [chemical binding]; other site
216389002625	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
216389002626	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
216389002627	dimer interface [polypeptide binding]; other site
216389002628	PYR/PP interface [polypeptide binding]; other site
216389002629	TPP binding site [chemical binding]; other site
216389002630	substrate binding site [chemical binding]; other site
216389002631	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
216389002632	TPP-binding site; other site
216389002633	Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cl02553
216389002634	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
216389002635	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
216389002636	DNA polymerase II large subunit; Validated; Region: PRK04023
216389002637	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
216389002638	trimerization site [polypeptide binding]; other site
216389002639	active site
216389002640	Predicted membrane protein [Function unknown]; Region: COG3462
216389002641	VbhA antitoxin and related proteins; Region: VbhA_like; cd11586
216389002642	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
216389002643	metal-binding site [ion binding]
216389002644	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
216389002645	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
216389002646	metal-binding site [ion binding]
216389002647	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
216389002648	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216389002649	motif II; other site
216389002650	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
216389002651	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
216389002652	putative dimer interface [polypeptide binding]; other site
216389002653	Ferritin-like domain; Region: Ferritin; pfam00210
216389002654	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
216389002655	dinuclear metal binding motif [ion binding]; other site
216389002656	Ferritin-like domain; Region: Ferritin; pfam00210
216389002657	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
216389002658	dinuclear metal binding motif [ion binding]; other site
216389002659	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
216389002660	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
216389002661	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
216389002662	AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657
216389002663	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
216389002664	Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659
216389002665	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
216389002666	Int/Topo IB signature motif; other site
216389002667	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
216389002668	reductive dehalogenase; Region: RDH; TIGR02486
216389002669	PAS domain S-box; Region: sensory_box; TIGR00229
216389002670	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216389002671	putative active site [active]
216389002672	heme pocket [chemical binding]; other site
216389002673	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
216389002674	Histidine kinase; Region: HisKA_3; pfam07730
216389002675	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216389002676	ATP binding site [chemical binding]; other site
216389002677	Mg2+ binding site [ion binding]; other site
216389002678	G-X-G motif; other site
216389002679	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
216389002680	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216389002681	active site
216389002682	phosphorylation site [posttranslational modification]
216389002683	intermolecular recognition site; other site
216389002684	dimerization interface [polypeptide binding]; other site
216389002685	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216389002686	DNA binding residues [nucleotide binding]
216389002687	dimerization interface [polypeptide binding]; other site
216389002688	Smr domain; Region: Smr; pfam01713
216389002689	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
216389002690	substrate binding site [chemical binding]; other site
216389002691	glutamase interaction surface [polypeptide binding]; other site
216389002692	Repressor of nif and glnA expression [Transcription]; Region: COG1693
216389002693	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
216389002694	Domain of unknown function DUF128; Region: DUF128; pfam01995
216389002695	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
216389002696	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
216389002697	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216389002698	FeS/SAM binding site; other site
216389002699	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
216389002700	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
216389002701	dimer interface [polypeptide binding]; other site
216389002702	active site
216389002703	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
216389002704	DHH family; Region: DHH; pfam01368
216389002705	DHHA1 domain; Region: DHHA1; pfam02272
216389002706	membrane protein; Provisional; Region: PRK14414
216389002707	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
216389002708	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
216389002709	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
216389002710	ATP binding site [chemical binding]; other site
216389002711	putative Mg++ binding site [ion binding]; other site
216389002712	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216389002713	nucleotide binding region [chemical binding]; other site
216389002714	ATP-binding site [chemical binding]; other site
216389002715	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
216389002716	Protein of unknown function (DUF503); Region: DUF503; pfam04456
216389002717	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
216389002718	16S/18S rRNA binding site [nucleotide binding]; other site
216389002719	S13e-L30e interaction site [polypeptide binding]; other site
216389002720	25S rRNA binding site [nucleotide binding]; other site
216389002721	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
216389002722	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
216389002723	RNase E interface [polypeptide binding]; other site
216389002724	trimer interface [polypeptide binding]; other site
216389002725	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
216389002726	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
216389002727	RNase E interface [polypeptide binding]; other site
216389002728	trimer interface [polypeptide binding]; other site
216389002729	active site
216389002730	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
216389002731	putative nucleic acid binding region [nucleotide binding]; other site
216389002732	G-X-X-G motif; other site
216389002733	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
216389002734	RNA binding site [nucleotide binding]; other site
216389002735	domain interface; other site
216389002736	dihydrodipicolinate reductase; Provisional; Region: PRK00048
216389002737	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
216389002738	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
216389002739	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
216389002740	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
216389002741	Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774
216389002742	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
216389002743	dimer interface [polypeptide binding]; other site
216389002744	active site
216389002745	catalytic residue [active]
216389002746	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
216389002747	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216389002748	Coenzyme A binding pocket [chemical binding]; other site
216389002749	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
216389002750	GDP-binding site [chemical binding]; other site
216389002751	ACT binding site; other site
216389002752	IMP binding site; other site
216389002753	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
216389002754	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
216389002755	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
216389002756	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
216389002757	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130
216389002758	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
216389002759	RNA binding site [nucleotide binding]; other site
216389002760	active site
216389002761	Ribosome-binding factor A; Region: RBFA; pfam02033
216389002762	translation initiation factor IF-2; Region: IF-2; TIGR00487
216389002763	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
216389002764	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
216389002765	G1 box; other site
216389002766	putative GEF interaction site [polypeptide binding]; other site
216389002767	GTP/Mg2+ binding site [chemical binding]; other site
216389002768	Switch I region; other site
216389002769	G2 box; other site
216389002770	G3 box; other site
216389002771	Switch II region; other site
216389002772	G4 box; other site
216389002773	G5 box; other site
216389002774	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
216389002775	Translation-initiation factor 2; Region: IF-2; pfam11987
216389002776	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
216389002777	Protein of unknown function (DUF448); Region: DUF448; pfam04296
216389002778	putative RNA binding cleft [nucleotide binding]; other site
216389002779	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
216389002780	NusA N-terminal domain; Region: NusA_N; pfam08529
216389002781	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
216389002782	RNA binding site [nucleotide binding]; other site
216389002783	homodimer interface [polypeptide binding]; other site
216389002784	NusA-like KH domain; Region: KH_5; pfam13184
216389002785	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
216389002786	G-X-X-G motif; other site
216389002787	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
216389002788	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
216389002789	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
216389002790	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216389002791	Walker A motif; other site
216389002792	ATP binding site [chemical binding]; other site
216389002793	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
216389002794	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
216389002795	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216389002796	Coenzyme A binding pocket [chemical binding]; other site
216389002797	Protein of unknown function (DUF502); Region: DUF502; cl01107
216389002798	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
216389002799	core dimer interface [polypeptide binding]; other site
216389002800	peripheral dimer interface [polypeptide binding]; other site
216389002801	L10 interface [polypeptide binding]; other site
216389002802	L11 interface [polypeptide binding]; other site
216389002803	putative EF-Tu interaction site [polypeptide binding]; other site
216389002804	putative EF-G interaction site [polypeptide binding]; other site
216389002805	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
216389002806	23S rRNA interface [nucleotide binding]; other site
216389002807	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
216389002808	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
216389002809	mRNA/rRNA interface [nucleotide binding]; other site
216389002810	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
216389002811	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
216389002812	23S rRNA interface [nucleotide binding]; other site
216389002813	L7/L12 interface [polypeptide binding]; other site
216389002814	putative thiostrepton binding site; other site
216389002815	L25 interface [polypeptide binding]; other site
216389002816	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
216389002817	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
216389002818	putative homodimer interface [polypeptide binding]; other site
216389002819	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
216389002820	heterodimer interface [polypeptide binding]; other site
216389002821	homodimer interface [polypeptide binding]; other site
216389002822	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
216389002823	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
216389002824	elongation factor Tu; Reviewed; Region: PRK00049
216389002825	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
216389002826	G1 box; other site
216389002827	GEF interaction site [polypeptide binding]; other site
216389002828	GTP/Mg2+ binding site [chemical binding]; other site
216389002829	Switch I region; other site
216389002830	G2 box; other site
216389002831	G3 box; other site
216389002832	Switch II region; other site
216389002833	G4 box; other site
216389002834	G5 box; other site
216389002835	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
216389002836	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
216389002837	Antibiotic Binding Site [chemical binding]; other site
216389002838	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
216389002839	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
216389002840	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
216389002841	putative ADP-binding pocket [chemical binding]; other site
216389002842	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
216389002843	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
216389002844	dimerization interface [polypeptide binding]; other site
216389002845	putative DNA binding site [nucleotide binding]; other site
216389002846	putative Zn2+ binding site [ion binding]; other site
216389002847	Predicted permease; Region: DUF318; cl17795
216389002848	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
216389002849	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
216389002850	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216389002851	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216389002852	putative substrate translocation pore; other site
216389002853	HPP family; Region: HPP; pfam04982
216389002854	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
216389002855	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
216389002856	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
216389002857	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
216389002858	acyl-activating enzyme (AAE) consensus motif; other site
216389002859	AMP binding site [chemical binding]; other site
216389002860	active site
216389002861	CoA binding site [chemical binding]; other site
216389002862	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216389002863	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
216389002864	putative active site [active]
216389002865	heme pocket [chemical binding]; other site
216389002866	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216389002867	putative active site [active]
216389002868	heme pocket [chemical binding]; other site
216389002869	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216389002870	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
216389002871	putative active site [active]
216389002872	heme pocket [chemical binding]; other site
216389002873	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216389002874	putative active site [active]
216389002875	heme pocket [chemical binding]; other site
216389002876	PAS domain S-box; Region: sensory_box; TIGR00229
216389002877	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216389002878	putative active site [active]
216389002879	heme pocket [chemical binding]; other site
216389002880	PAS domain S-box; Region: sensory_box; TIGR00229
216389002881	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216389002882	putative active site [active]
216389002883	heme pocket [chemical binding]; other site
216389002884	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
216389002885	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216389002886	putative active site [active]
216389002887	heme pocket [chemical binding]; other site
216389002888	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216389002889	dimer interface [polypeptide binding]; other site
216389002890	phosphorylation site [posttranslational modification]
216389002891	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216389002892	ATP binding site [chemical binding]; other site
216389002893	Mg2+ binding site [ion binding]; other site
216389002894	G-X-G motif; other site
216389002895	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216389002896	active site
216389002897	phosphorylation site [posttranslational modification]
216389002898	intermolecular recognition site; other site
216389002899	dimerization interface [polypeptide binding]; other site
216389002900	Protein of unknown function (DUF4256); Region: DUF4256; pfam14066
216389002901	ribonuclease III; Reviewed; Region: rnc; PRK00102
216389002902	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
216389002903	dimerization interface [polypeptide binding]; other site
216389002904	active site
216389002905	metal binding site [ion binding]; metal-binding site
216389002906	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
216389002907	dsRNA binding site [nucleotide binding]; other site
216389002908	acylphosphatase; Provisional; Region: PRK14450
216389002909	Domain of unknown function (DUF362); Region: DUF362; cl19822
216389002910	multifunctional aminopeptidase A; Provisional; Region: PRK00913
216389002911	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
216389002912	interface (dimer of trimers) [polypeptide binding]; other site
216389002913	Substrate-binding/catalytic site; other site
216389002914	Zn-binding sites [ion binding]; other site
216389002915	AAA domain; Region: AAA_17; cl19128
216389002916	AAA domain; Region: AAA_33; pfam13671
216389002917	EDD domain protein, DegV family; Region: DegV; TIGR00762
216389002918	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
216389002919	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
216389002920	acyl-activating enzyme (AAE) consensus motif; other site
216389002921	active site
216389002922	AMP binding site [chemical binding]; other site
216389002923	CoA binding site [chemical binding]; other site
216389002924	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
216389002925	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216389002926	catalytic residue [active]
216389002927	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
216389002928	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
216389002929	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
216389002930	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
216389002931	protein binding site [polypeptide binding]; other site
216389002932	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
216389002933	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
216389002934	active site
216389002935	HIGH motif; other site
216389002936	nucleotide binding site [chemical binding]; other site
216389002937	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
216389002938	active site
216389002939	KMSKS motif; other site
216389002940	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
216389002941	tRNA binding surface [nucleotide binding]; other site
216389002942	anticodon binding site; other site
216389002943	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
216389002944	Jag N-terminus; Region: Jag_N; pfam14804
216389002945	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
216389002946	G-X-X-G motif; other site
216389002947	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
216389002948	RxxxH motif; other site
216389002949	PQQ-like domain; Region: PQQ_2; pfam13360
216389002950	beta-propeller repeat; Region: PQQ; smart00564
216389002951	PQQ-like domain; Region: PQQ_2; pfam13360
216389002952	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
216389002953	active site
216389002954	Trp docking motif [polypeptide binding]; other site
216389002955	Ribonuclease P; Region: Ribonuclease_P; pfam00825
216389002956	Ribosomal protein L34; Region: Ribosomal_L34; pfam00468
216389002957	30S ribosomal protein S18; Provisional; Region: PRK13400
216389002958	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
216389002959	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
216389002960	dimer interface [polypeptide binding]; other site
216389002961	ssDNA binding site [nucleotide binding]; other site
216389002962	tetramer (dimer of dimers) interface [polypeptide binding]; other site
216389002963	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
216389002964	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
216389002965	homotrimer interaction site [polypeptide binding]; other site
216389002966	putative active site [active]
216389002967	Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
216389002968	Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017
216389002969	nucleotide binding site [chemical binding]; other site
216389002970	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
216389002971	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
216389002972	Walker A/P-loop; other site
216389002973	ATP binding site [chemical binding]; other site
216389002974	Q-loop/lid; other site
216389002975	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
216389002976	Q-loop/lid; other site
216389002977	ABC transporter signature motif; other site
216389002978	Walker B; other site
216389002979	D-loop; other site
216389002980	H-loop/switch region; other site
216389002981	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
216389002982	EamA-like transporter family; Region: EamA; pfam00892
216389002983	EamA-like transporter family; Region: EamA; pfam00892
216389002984	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
216389002985	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216389002986	active site
216389002987	phosphorylation site [posttranslational modification]
216389002988	intermolecular recognition site; other site
216389002989	dimerization interface [polypeptide binding]; other site
216389002990	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216389002991	DNA binding site [nucleotide binding]
216389002992	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216389002993	dimerization interface [polypeptide binding]; other site
216389002994	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216389002995	dimer interface [polypeptide binding]; other site
216389002996	phosphorylation site [posttranslational modification]
216389002997	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216389002998	ATP binding site [chemical binding]; other site
216389002999	Mg2+ binding site [ion binding]; other site
216389003000	G-X-G motif; other site
216389003001	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
216389003002	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
216389003003	Walker A/P-loop; other site
216389003004	ATP binding site [chemical binding]; other site
216389003005	Q-loop/lid; other site
216389003006	ABC transporter signature motif; other site
216389003007	Walker B; other site
216389003008	D-loop; other site
216389003009	H-loop/switch region; other site
216389003010	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
216389003011	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
216389003012	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
216389003013	Walker A/P-loop; other site
216389003014	ATP binding site [chemical binding]; other site
216389003015	Q-loop/lid; other site
216389003016	ABC transporter signature motif; other site
216389003017	Walker B; other site
216389003018	D-loop; other site
216389003019	H-loop/switch region; other site
216389003020	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
216389003021	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
216389003022	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
216389003023	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216389003024	dimer interface [polypeptide binding]; other site
216389003025	conserved gate region; other site
216389003026	putative PBP binding loops; other site
216389003027	ABC-ATPase subunit interface; other site
216389003028	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
216389003029	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216389003030	dimer interface [polypeptide binding]; other site
216389003031	conserved gate region; other site
216389003032	putative PBP binding loops; other site
216389003033	ABC-ATPase subunit interface; other site
216389003034	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
216389003035	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
216389003036	peptide binding site [polypeptide binding]; other site
216389003037	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
216389003038	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
216389003039	Beta-Casp domain; Region: Beta-Casp; smart01027
216389003040	RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521
216389003041	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
216389003042	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216389003043	active site
216389003044	phosphorylation site [posttranslational modification]
216389003045	intermolecular recognition site; other site
216389003046	dimerization interface [polypeptide binding]; other site
216389003047	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216389003048	DNA binding residues [nucleotide binding]
216389003049	dimerization interface [polypeptide binding]; other site
216389003050	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216389003051	PAS domain; Region: PAS_9; pfam13426
216389003052	putative active site [active]
216389003053	heme pocket [chemical binding]; other site
216389003054	PAS fold; Region: PAS_4; pfam08448
216389003055	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216389003056	putative active site [active]
216389003057	heme pocket [chemical binding]; other site
216389003058	GAF domain; Region: GAF_2; pfam13185
216389003059	PAS domain S-box; Region: sensory_box; TIGR00229
216389003060	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216389003061	putative active site [active]
216389003062	heme pocket [chemical binding]; other site
216389003063	PAS domain; Region: PAS; smart00091
216389003064	PAS domain; Region: PAS_9; pfam13426
216389003065	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
216389003066	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216389003067	putative active site [active]
216389003068	heme pocket [chemical binding]; other site
216389003069	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216389003070	putative active site [active]
216389003071	heme pocket [chemical binding]; other site
216389003072	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
216389003073	Histidine kinase; Region: HisKA_3; pfam07730
216389003074	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216389003075	ATP binding site [chemical binding]; other site
216389003076	Mg2+ binding site [ion binding]; other site
216389003077	G-X-G motif; other site
216389003078	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
216389003079	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216389003080	S-adenosylmethionine binding site [chemical binding]; other site
216389003081	Carbonic anhydrase; Region: Pro_CA; smart00947
216389003082	active site clefts [active]
216389003083	zinc binding site [ion binding]; other site
216389003084	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
216389003085	active site
216389003086	dimer interface [polypeptide binding]; other site
216389003087	Protein of unknown function (DUF3795); Region: DUF3795; pfam12675
216389003088	NAD synthetase; Provisional; Region: PRK13981
216389003089	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
216389003090	multimer interface [polypeptide binding]; other site
216389003091	active site
216389003092	catalytic triad [active]
216389003093	protein interface 1 [polypeptide binding]; other site
216389003094	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
216389003095	homodimer interface [polypeptide binding]; other site
216389003096	NAD binding pocket [chemical binding]; other site
216389003097	ATP binding pocket [chemical binding]; other site
216389003098	Mg binding site [ion binding]; other site
216389003099	active-site loop [active]
216389003100	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
216389003101	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
216389003102	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
216389003103	Nitrogen regulatory protein P-II; Region: P-II; smart00938
216389003104	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
216389003105	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
216389003106	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216389003107	DNA binding site [nucleotide binding]
216389003108	Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981
216389003109	putative subunit interface; other site
216389003110	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
216389003111	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
216389003112	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
216389003113	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
216389003114	active site
216389003115	FMN binding site [chemical binding]; other site
216389003116	substrate binding site [chemical binding]; other site
216389003117	3Fe-4S cluster binding site [ion binding]; other site
216389003118	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
216389003119	substrate binding site [chemical binding]; other site
216389003120	glutamase interaction surface [polypeptide binding]; other site
216389003121	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
216389003122	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
216389003123	putative active site [active]
216389003124	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
216389003125	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
216389003126	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
216389003127	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142
216389003128	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
216389003129	putative active site [active]
216389003130	oxyanion strand; other site
216389003131	catalytic triad [active]
216389003132	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
216389003133	Predicted membrane protein [Function unknown]; Region: COG1971
216389003134	Domain of unknown function DUF; Region: DUF204; pfam02659
216389003135	Domain of unknown function DUF; Region: DUF204; pfam02659
216389003136	cysteine synthase; Region: PLN02565
216389003137	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
216389003138	dimer interface [polypeptide binding]; other site
216389003139	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216389003140	catalytic residue [active]
216389003141	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216389003142	FeS/SAM binding site; other site
216389003143	Radical SAM superfamily; Region: Radical_SAM; pfam04055
216389003144	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
216389003145	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572
216389003146	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
216389003147	active site
216389003148	catalytic triad [active]
216389003149	dimer interface [polypeptide binding]; other site
216389003150	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
216389003151	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
216389003152	DXD motif; other site
216389003153	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
216389003154	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
216389003155	NodB motif; other site
216389003156	active site
216389003157	catalytic site [active]
216389003158	metal binding site [ion binding]; metal-binding site
216389003159	Protease prsW family; Region: PrsW-protease; pfam13367
216389003160	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
216389003161	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216389003162	active site
216389003163	phosphorylation site [posttranslational modification]
216389003164	intermolecular recognition site; other site
216389003165	dimerization interface [polypeptide binding]; other site
216389003166	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216389003167	DNA binding residues [nucleotide binding]
216389003168	dimerization interface [polypeptide binding]; other site
216389003169	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
216389003170	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
216389003171	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
216389003172	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
216389003173	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
216389003174	Transposase; Region: HTH_Tnp_1; cl17663
216389003175	HTH-like domain; Region: HTH_21; pfam13276
216389003176	Integrase core domain; Region: rve; pfam00665
216389003177	DDE domain; Region: DDE_Tnp_IS240; pfam13610
216389003178	Integrase core domain; Region: rve_3; pfam13683
216389003179	CoA binding domain; Region: CoA_binding_2; pfam13380
216389003180	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
216389003181	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
216389003182	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
216389003183	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
216389003184	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
216389003185	metal binding site 2 [ion binding]; metal-binding site
216389003186	putative DNA binding helix; other site
216389003187	metal binding site 1 [ion binding]; metal-binding site
216389003188	dimer interface [polypeptide binding]; other site
216389003189	structural Zn2+ binding site [ion binding]; other site
216389003190	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
216389003191	Predicted transcriptional regulators [Transcription]; Region: COG1695
216389003192	Transcriptional regulators [Transcription]; Region: MarR; COG1846
216389003193	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
216389003194	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
216389003195	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
216389003196	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216389003197	Walker A/P-loop; other site
216389003198	ATP binding site [chemical binding]; other site
216389003199	Q-loop/lid; other site
216389003200	ABC transporter signature motif; other site
216389003201	Walker B; other site
216389003202	D-loop; other site
216389003203	H-loop/switch region; other site
216389003204	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
216389003205	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
216389003206	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
216389003207	Walker A/P-loop; other site
216389003208	ATP binding site [chemical binding]; other site
216389003209	Q-loop/lid; other site
216389003210	ABC transporter signature motif; other site
216389003211	Walker B; other site
216389003212	D-loop; other site
216389003213	H-loop/switch region; other site
216389003214	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
216389003215	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
216389003216	Transcriptional regulators [Transcription]; Region: MarR; COG1846
216389003217	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
216389003218	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
216389003219	reductive dehalogenase; Region: RDH; TIGR02486
216389003220	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
216389003221	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
216389003222	Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834
216389003223	Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955
216389003224	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
216389003225	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
216389003226	trimer interface [polypeptide binding]; other site
216389003227	active site
216389003228	substrate binding site [chemical binding]; other site
216389003229	CoA binding site [chemical binding]; other site
216389003230	BioY family; Region: BioY; pfam02632
216389003231	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cd01342
216389003232	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
216389003233	homopentamer interface [polypeptide binding]; other site
216389003234	active site
216389003235	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
216389003236	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
216389003237	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
216389003238	dimerization interface [polypeptide binding]; other site
216389003239	active site
216389003240	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
216389003241	Lumazine binding domain; Region: Lum_binding; pfam00677
216389003242	Lumazine binding domain; Region: Lum_binding; pfam00677
216389003243	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
216389003244	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
216389003245	catalytic motif [active]
216389003246	Zn binding site [ion binding]; other site
216389003247	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
216389003248	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
216389003249	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
216389003250	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
216389003251	Catalytic site [active]
216389003252	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
216389003253	active site
216389003254	Endonuclease related to archaeal Holliday junction resolvase; Region: Endonuc_Holl; pfam10107
216389003255	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
216389003256	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216389003257	ATP binding site [chemical binding]; other site
216389003258	Mg2+ binding site [ion binding]; other site
216389003259	G-X-G motif; other site
216389003260	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
216389003261	ATP binding site [chemical binding]; other site
216389003262	MutL C terminal dimerization domain; Region: MutL_C; pfam08676
216389003263	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
216389003264	Part of AAA domain; Region: AAA_19; pfam13245
216389003265	AAA domain; Region: AAA_12; pfam13087
216389003266	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
216389003267	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
216389003268	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
216389003269	active site
216389003270	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
216389003271	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
216389003272	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
216389003273	dihydroorotase; Validated; Region: pyrC; PRK09357
216389003274	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
216389003275	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
216389003276	active site
216389003277	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
216389003278	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
216389003279	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
216389003280	catalytic site [active]
216389003281	subunit interface [polypeptide binding]; other site
216389003282	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
216389003283	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
216389003284	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
216389003285	Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787
216389003286	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
216389003287	ATP-grasp domain; Region: ATP-grasp_4; cl17255
216389003288	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
216389003289	IMP binding site; other site
216389003290	dimer interface [polypeptide binding]; other site
216389003291	interdomain contacts; other site
216389003292	partial ornithine binding site; other site
216389003293	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
216389003294	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
216389003295	FAD binding pocket [chemical binding]; other site
216389003296	FAD binding motif [chemical binding]; other site
216389003297	phosphate binding motif [ion binding]; other site
216389003298	beta-alpha-beta structure motif; other site
216389003299	NAD binding pocket [chemical binding]; other site
216389003300	Iron coordination center [ion binding]; other site
216389003301	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
216389003302	active site
216389003303	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
216389003304	homodimer interface [polypeptide binding]; other site
216389003305	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216389003306	catalytic residue [active]
216389003307	homoserine dehydrogenase; Provisional; Region: PRK06349
216389003308	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
216389003309	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
216389003310	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
216389003311	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
216389003312	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
216389003313	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
216389003314	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
216389003315	active site
216389003316	Substrate binding site; other site
216389003317	Mg++ binding site; other site
216389003318	Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132
216389003319	Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356
216389003320	acetyl-CoA synthetase; Provisional; Region: PRK00174
216389003321	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
216389003322	active site
216389003323	CoA binding site [chemical binding]; other site
216389003324	acyl-activating enzyme (AAE) consensus motif; other site
216389003325	AMP binding site [chemical binding]; other site
216389003326	acetate binding site [chemical binding]; other site
216389003327	peptide chain release factor 1; Validated; Region: prfA; PRK00591
216389003328	PCRF domain; Region: PCRF; pfam03462
216389003329	RF-1 domain; Region: RF-1; pfam00472
216389003330	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
216389003331	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216389003332	S-adenosylmethionine binding site [chemical binding]; other site
216389003333	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
216389003334	elongation factor G; Reviewed; Region: PRK12740
216389003335	G1 box; other site
216389003336	putative GEF interaction site [polypeptide binding]; other site
216389003337	GTP/Mg2+ binding site [chemical binding]; other site
216389003338	Switch I region; other site
216389003339	G2 box; other site
216389003340	G3 box; other site
216389003341	Switch II region; other site
216389003342	G4 box; other site
216389003343	G5 box; other site
216389003344	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
216389003345	Elongation Factor G, domain II; Region: EFG_II; pfam14492
216389003346	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
216389003347	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
216389003348	Integral membrane protein DUF95; Region: DUF95; pfam01944
216389003349	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
216389003350	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
216389003351	active site
216389003352	Int/Topo IB signature motif; other site
216389003353	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
216389003354	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
216389003355	GIY-YIG motif/motif A; other site
216389003356	active site
216389003357	catalytic site [active]
216389003358	putative DNA binding site [nucleotide binding]; other site
216389003359	metal binding site [ion binding]; metal-binding site
216389003360	UvrB/uvrC motif; Region: UVR; pfam02151
216389003361	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
216389003362	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216389003363	Coenzyme A binding pocket [chemical binding]; other site
216389003364	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216389003365	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
216389003366	active site
216389003367	motif I; other site
216389003368	motif II; other site
216389003369	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
216389003370	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
216389003371	MutS domain I; Region: MutS_I; pfam01624
216389003372	MutS domain II; Region: MutS_II; pfam05188
216389003373	MutS domain III; Region: MutS_III; pfam05192
216389003374	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
216389003375	Walker A/P-loop; other site
216389003376	ATP binding site [chemical binding]; other site
216389003377	Q-loop/lid; other site
216389003378	ABC transporter signature motif; other site
216389003379	Walker B; other site
216389003380	D-loop; other site
216389003381	H-loop/switch region; other site
216389003382	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
216389003383	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
216389003384	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
216389003385	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572
216389003386	Fructose-1,6-bisphosphatase; Region: FBPase_3; pfam01950
216389003387	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
216389003388	active site
216389003389	dimerization interface [polypeptide binding]; other site
216389003390	DNA polymerase III subunit beta; Validated; Region: PRK05643
216389003391	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
216389003392	putative DNA binding surface [nucleotide binding]; other site
216389003393	dimer interface [polypeptide binding]; other site
216389003394	beta-clamp/clamp loader binding surface; other site
216389003395	beta-clamp/translesion DNA polymerase binding surface; other site
216389003396	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
216389003397	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
216389003398	catalytic residues [active]
216389003399	catalytic nucleophile [active]
216389003400	Recombinase; Region: Recombinase; pfam07508
216389003401	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
216389003402	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
216389003403	Replication initiation factor; Region: Rep_trans; pfam02486
216389003404	DNA methylase; Region: N6_N4_Mtase; pfam01555
216389003405	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
216389003406	Methyltransferase domain; Region: Methyltransf_26; pfam13659
216389003407	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
216389003408	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
216389003409	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
216389003410	head completion protein; Provisional; Region: 4; PHA02552
216389003411	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
216389003412	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
216389003413	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
216389003414	Domain of unknown function (DU1801); Region: DUF1801; cl17490
216389003415	Putative lysophospholipase; Region: Hydrolase_4; cl19140
216389003416	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
216389003417	Smr domain; Region: Smr; pfam01713
216389003418	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
216389003419	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
216389003420	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
216389003421	putative active site [active]
216389003422	putative substrate binding site [chemical binding]; other site
216389003423	putative cosubstrate binding site; other site
216389003424	catalytic site [active]
216389003425	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
216389003426	active site
216389003427	arsenical-resistance protein; Region: acr3; TIGR00832
216389003428	methionine sulfoxide reductase A; Provisional; Region: PRK14054
216389003429	methionine sulfoxide reductase B; Provisional; Region: PRK05508
216389003430	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
216389003431	TfoX N-terminal domain; Region: TfoX_N; pfam04993
216389003432	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
216389003433	dimerization interface [polypeptide binding]; other site
216389003434	putative DNA binding site [nucleotide binding]; other site
216389003435	putative Zn2+ binding site [ion binding]; other site
216389003436	Predicted integral membrane protein [Function unknown]; Region: COG5658
216389003437	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
216389003438	SdpI/YhfL protein family; Region: SdpI; pfam13630
216389003439	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
216389003440	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
216389003441	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
216389003442	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
216389003443	Walker A motif; other site
216389003444	ATP binding site [chemical binding]; other site
216389003445	Walker B motif; other site
216389003446	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
216389003447	heterotetramer interface [polypeptide binding]; other site
216389003448	active site pocket [active]
216389003449	cleavage site
216389003450	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
216389003451	nucleotide binding site [chemical binding]; other site
216389003452	N-acetyl-L-glutamate binding site [chemical binding]; other site
216389003453	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
216389003454	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
216389003455	inhibitor-cofactor binding pocket; inhibition site
216389003456	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216389003457	catalytic residue [active]
216389003458	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
216389003459	ANP binding site [chemical binding]; other site
216389003460	Substrate Binding Site II [chemical binding]; other site
216389003461	Substrate Binding Site I [chemical binding]; other site
216389003462	argininosuccinate lyase; Provisional; Region: PRK00855
216389003463	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
216389003464	active sites [active]
216389003465	tetramer interface [polypeptide binding]; other site
216389003466	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
216389003467	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
216389003468	DAK2 domain; Region: Dak2; pfam02734
216389003469	Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684
216389003470	EDD domain protein, DegV family; Region: DegV; TIGR00762
216389003471	EDD domain protein, DegV family; Region: DegV; TIGR00762
216389003472	EDD domain protein, DegV family; Region: DegV; TIGR00762
216389003473	EDD domain protein, DegV family; Region: DegV; TIGR00762
216389003474	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
216389003475	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
216389003476	generic binding surface II; other site
216389003477	ssDNA binding site; other site
216389003478	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
216389003479	ATP binding site [chemical binding]; other site
216389003480	putative Mg++ binding site [ion binding]; other site
216389003481	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216389003482	nucleotide binding region [chemical binding]; other site
216389003483	ATP-binding site [chemical binding]; other site
216389003484	SAD/SRA domain; Region: SAD_SRA; cl02620
216389003485	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
216389003486	active site
216389003487	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
216389003488	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
216389003489	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
216389003490	active site
216389003491	HIGH motif; other site
216389003492	KMSK motif region; other site
216389003493	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
216389003494	tRNA binding surface [nucleotide binding]; other site
216389003495	anticodon binding site; other site
216389003496	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
216389003497	AsnC family; Region: AsnC_trans_reg; pfam01037
216389003498	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
216389003499	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
216389003500	NAD binding site [chemical binding]; other site
216389003501	homotetramer interface [polypeptide binding]; other site
216389003502	homodimer interface [polypeptide binding]; other site
216389003503	substrate binding site [chemical binding]; other site
216389003504	active site
216389003505	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
216389003506	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
216389003507	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
216389003508	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
216389003509	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
216389003510	NAD(P) binding site [chemical binding]; other site
216389003511	homotetramer interface [polypeptide binding]; other site
216389003512	homodimer interface [polypeptide binding]; other site
216389003513	active site
216389003514	transcription antitermination factor NusB; Region: nusB; TIGR01951
216389003515	putative RNA binding site [nucleotide binding]; other site
216389003516	acyl carrier protein; Provisional; Region: acpP; PRK00982
216389003517	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
216389003518	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
216389003519	B12 binding site [chemical binding]; other site
216389003520	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216389003521	FeS/SAM binding site; other site
216389003522	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
216389003523	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
216389003524	Bifunctional transglycosylase second domain; Region: UB2H; pfam14814
216389003525	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
216389003526	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
216389003527	ATP binding site [chemical binding]; other site
216389003528	putative Mg++ binding site [ion binding]; other site
216389003529	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216389003530	nucleotide binding region [chemical binding]; other site
216389003531	ATP-binding site [chemical binding]; other site
216389003532	TRCF domain; Region: TRCF; pfam03461
216389003533	gamma-glutamyl kinase; Provisional; Region: PRK05429
216389003534	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
216389003535	nucleotide binding site [chemical binding]; other site
216389003536	homotetrameric interface [polypeptide binding]; other site
216389003537	putative phosphate binding site [ion binding]; other site
216389003538	putative allosteric binding site; other site
216389003539	PUA domain; Region: PUA; pfam01472
216389003540	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
216389003541	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
216389003542	protein binding site [polypeptide binding]; other site
216389003543	FlxA-like protein; Region: FlxA; pfam14282
216389003544	Trypsin; Region: Trypsin; pfam00089
216389003545	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
216389003546	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
216389003547	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
216389003548	DNA binding residues [nucleotide binding]
216389003549	dimer interface [polypeptide binding]; other site
216389003550	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
216389003551	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
216389003552	putative catalytic cysteine [active]
216389003553	ribonuclease PH; Reviewed; Region: rph; PRK00173
216389003554	Ribonuclease PH; Region: RNase_PH_bact; cd11362
216389003555	hexamer interface [polypeptide binding]; other site
216389003556	active site
216389003557	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
216389003558	nudix motif; other site
216389003559	Competence-damaged protein; Region: CinA; pfam02464
216389003560	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
216389003561	PAS domain S-box; Region: sensory_box; TIGR00229
216389003562	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
216389003563	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216389003564	dimer interface [polypeptide binding]; other site
216389003565	phosphorylation site [posttranslational modification]
216389003566	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216389003567	ATP binding site [chemical binding]; other site
216389003568	Mg2+ binding site [ion binding]; other site
216389003569	G-X-G motif; other site
216389003570	Helix-turn-helix domain; Region: HTH_17; pfam12728
216389003571	Response regulator receiver domain; Region: Response_reg; pfam00072
216389003572	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216389003573	active site
216389003574	phosphorylation site [posttranslational modification]
216389003575	intermolecular recognition site; other site
216389003576	dimerization interface [polypeptide binding]; other site
216389003577	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
216389003578	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
216389003579	Probable zinc-binding domain; Region: zf-trcl; pfam13451
216389003580	CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272
216389003581	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
216389003582	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
216389003583	G1 box; other site
216389003584	putative GEF interaction site [polypeptide binding]; other site
216389003585	GTP/Mg2+ binding site [chemical binding]; other site
216389003586	Switch I region; other site
216389003587	G2 box; other site
216389003588	G3 box; other site
216389003589	Switch II region; other site
216389003590	G4 box; other site
216389003591	G5 box; other site
216389003592	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
216389003593	Elongation Factor G, domain II; Region: EFG_II; pfam14492
216389003594	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
216389003595	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216389003596	metabolite-proton symporter; Region: 2A0106; TIGR00883
216389003597	putative substrate translocation pore; other site
216389003598	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
216389003599	Ligand Binding Site [chemical binding]; other site
216389003600	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
216389003601	Fasciclin domain; Region: Fasciclin; pfam02469
216389003602	Glycosyl transferase 4-like; Region: Glyco_trans_4_2; pfam13477
216389003603	Uncharacterized conserved protein [Function unknown]; Region: COG3422
216389003604	Putative lysophospholipase; Region: Hydrolase_4; cl19140
216389003605	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
216389003606	Putative lysophospholipase; Region: Hydrolase_4; cl19140
216389003607	recombination factor protein RarA; Reviewed; Region: PRK13342
216389003608	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216389003609	Walker A motif; other site
216389003610	ATP binding site [chemical binding]; other site
216389003611	Walker B motif; other site
216389003612	arginine finger; other site
216389003613	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
216389003614	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
216389003615	putative ligand binding pocket/active site [active]
216389003616	putative metal binding site [ion binding]; other site
216389003617	AMMECR1; Region: AMMECR1; pfam01871
216389003618	Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180
216389003619	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216389003620	FeS/SAM binding site; other site
216389003621	EamA-like transporter family; Region: EamA; pfam00892
216389003622	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
216389003623	Renin receptor-like protein; Region: Renin_r; pfam07850
216389003624	YcxB-like protein; Region: YcxB; pfam14317
216389003625	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216389003626	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
216389003627	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
216389003628	Walker A/P-loop; other site
216389003629	Walker A/P-loop; other site
216389003630	ATP binding site [chemical binding]; other site
216389003631	ATP binding site [chemical binding]; other site
216389003632	Q-loop/lid; other site
216389003633	ABC transporter signature motif; other site
216389003634	Walker B; other site
216389003635	D-loop; other site
216389003636	H-loop/switch region; other site
216389003637	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
216389003638	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216389003639	Coenzyme A binding pocket [chemical binding]; other site
216389003640	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
216389003641	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
216389003642	CoA-binding site [chemical binding]; other site
216389003643	ATP-binding [chemical binding]; other site
216389003644	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
216389003645	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216389003646	NAD(P) binding site [chemical binding]; other site
216389003647	active site
216389003648	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
216389003649	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
216389003650	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
216389003651	Protein of unknown function (DUF1385); Region: DUF1385; pfam07136
216389003652	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
216389003653	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
216389003654	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216389003655	Coenzyme A binding pocket [chemical binding]; other site
216389003656	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
216389003657	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
216389003658	catalytic residues [active]
216389003659	Protein of unknown function (DUF2769); Region: DUF2769; pfam10967
216389003660	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
216389003661	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
216389003662	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
216389003663	Predicted membrane protein (DUF2178); Region: DUF2178; pfam09946
216389003664	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
216389003665	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216389003666	non-specific DNA binding site [nucleotide binding]; other site
216389003667	salt bridge; other site
216389003668	sequence-specific DNA binding site [nucleotide binding]; other site
216389003669	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
216389003670	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216389003671	Walker A/P-loop; other site
216389003672	ATP binding site [chemical binding]; other site
216389003673	Q-loop/lid; other site
216389003674	ABC transporter signature motif; other site
216389003675	Walker B; other site
216389003676	D-loop; other site
216389003677	H-loop/switch region; other site
216389003678	Acyltransferase family; Region: Acyl_transf_3; cl19154
216389003679	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
216389003680	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
216389003681	aspartate aminotransferase; Provisional; Region: PRK05764
216389003682	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216389003683	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216389003684	homodimer interface [polypeptide binding]; other site
216389003685	catalytic residue [active]
216389003686	tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927
216389003687	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
216389003688	active site
216389003689	HIGH motif; other site
216389003690	dimer interface [polypeptide binding]; other site
216389003691	KMSKS motif; other site
216389003692	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944
216389003693	Fe-S cluster binding site [ion binding]; other site
216389003694	substrate binding site [chemical binding]; other site
216389003695	catalytic site [active]
216389003696	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12858
216389003697	catalytic residue [active]
216389003698	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
216389003699	putative substrate binding site [chemical binding]; other site
216389003700	putative ATP binding site [chemical binding]; other site
216389003701	RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2
216389003702	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216389003703	Sigma-70, region 4; Region: Sigma70_r4; pfam04545
216389003704	DNA binding residues [nucleotide binding]
216389003705	Helix-turn-helix domain; Region: HTH_17; pfam12728
216389003706	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
216389003707	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216389003708	active site
216389003709	phosphorylation site [posttranslational modification]
216389003710	intermolecular recognition site; other site
216389003711	dimerization interface [polypeptide binding]; other site
216389003712	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216389003713	DNA binding residues [nucleotide binding]
216389003714	dimerization interface [polypeptide binding]; other site
216389003715	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
216389003716	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
216389003717	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
216389003718	Walker A motif; other site
216389003719	ATP binding site [chemical binding]; other site
216389003720	Walker B motif; other site
216389003721	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
216389003722	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
216389003723	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
216389003724	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
216389003725	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
216389003726	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
216389003727	PilX N-terminal; Region: PilX_N; pfam14341
216389003728	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
216389003729	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
216389003730	Walker A motif; other site
216389003731	ATP binding site [chemical binding]; other site
216389003732	Walker B motif; other site
216389003733	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
216389003734	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
216389003735	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
216389003736	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
216389003737	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
216389003738	bifunctional mannosyl-3-phosphoglycerate synthase/mannosyl-3 phosphoglycerate phosphatase; Provisional; Region: PRK14502
216389003739	Mannosyl-3-phosphoglycerate synthase (osmo_MPGsynth); Region: Osmo_MPGsynth; pfam09488
216389003740	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
216389003741	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216389003742	active site
216389003743	motif I; other site
216389003744	motif II; other site
216389003745	RDD family; Region: RDD; pfam06271
216389003746	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
216389003747	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
216389003748	active site
216389003749	HIGH motif; other site
216389003750	KMSKS motif; other site
216389003751	Protein of unknown function (DUF3795); Region: DUF3795; pfam12675
216389003752	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216389003753	FeS/SAM binding site; other site
216389003754	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
216389003755	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
216389003756	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
216389003757	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
216389003758	heterodimer interface [polypeptide binding]; other site
216389003759	active site
216389003760	FMN binding site [chemical binding]; other site
216389003761	homodimer interface [polypeptide binding]; other site
216389003762	substrate binding site [chemical binding]; other site
216389003763	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
216389003764	lipoprotein signal peptidase; Provisional; Region: PRK14784
216389003765	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
216389003766	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
216389003767	RNA binding surface [nucleotide binding]; other site
216389003768	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
216389003769	active site
216389003770	Winged helix-turn-helix; Region: HTH_45; pfam14947
216389003771	Phospholipid methyltransferase; Region: PEMT; cl17370
216389003772	GH3 auxin-responsive promoter; Region: GH3; pfam03321
216389003773	indole-3-acetic acid-amido synthetase; Region: PLN02249
216389003774	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; cl09440
216389003775	GAF domain; Region: GAF_2; pfam13185
216389003776	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216389003777	metal binding site [ion binding]; metal-binding site
216389003778	active site
216389003779	I-site; other site
216389003780	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
216389003781	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
216389003782	Zn2+ binding site [ion binding]; other site
216389003783	Mg2+ binding site [ion binding]; other site
216389003784	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
216389003785	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
216389003786	dimerization interface [polypeptide binding]; other site
216389003787	active site
216389003788	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
216389003789	L-aspartate oxidase; Provisional; Region: PRK06175
216389003790	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
216389003791	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
216389003792	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14336
216389003793	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
216389003794	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216389003795	FeS/SAM binding site; other site
216389003796	TRAM domain; Region: TRAM; pfam01938
216389003797	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
216389003798	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
216389003799	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
216389003800	DNA binding site [nucleotide binding]
216389003801	catalytic residue [active]
216389003802	H2TH interface [polypeptide binding]; other site
216389003803	putative catalytic residues [active]
216389003804	turnover-facilitating residue; other site
216389003805	intercalation triad [nucleotide binding]; other site
216389003806	8OG recognition residue [nucleotide binding]; other site
216389003807	putative reading head residues; other site
216389003808	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
216389003809	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
216389003810	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
216389003811	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
216389003812	active site
216389003813	DNA polymerase I; Provisional; Region: PRK05755
216389003814	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
216389003815	active site
216389003816	metal binding site 1 [ion binding]; metal-binding site
216389003817	putative 5' ssDNA interaction site; other site
216389003818	metal binding site 3; metal-binding site
216389003819	metal binding site 2 [ion binding]; metal-binding site
216389003820	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
216389003821	putative DNA binding site [nucleotide binding]; other site
216389003822	putative metal binding site [ion binding]; other site
216389003823	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
216389003824	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
216389003825	active site
216389003826	DNA binding site [nucleotide binding]
216389003827	catalytic site [active]
216389003828	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
216389003829	active site residue [active]
216389003830	ornithine carbamoyltransferase; Provisional; Region: PRK00779
216389003831	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
216389003832	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
216389003833	GTP-binding protein Der; Reviewed; Region: PRK00093
216389003834	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
216389003835	G1 box; other site
216389003836	GTP/Mg2+ binding site [chemical binding]; other site
216389003837	Switch I region; other site
216389003838	G2 box; other site
216389003839	Switch II region; other site
216389003840	G3 box; other site
216389003841	G4 box; other site
216389003842	G5 box; other site
216389003843	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
216389003844	G1 box; other site
216389003845	GTP/Mg2+ binding site [chemical binding]; other site
216389003846	Switch I region; other site
216389003847	G2 box; other site
216389003848	G3 box; other site
216389003849	Switch II region; other site
216389003850	G4 box; other site
216389003851	G5 box; other site
216389003852	KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714
216389003853	membrane protein; Provisional; Region: PRK14415
216389003854	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
216389003855	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
216389003856	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
216389003857	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
216389003858	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
216389003859	HSP70 interaction site [polypeptide binding]; other site
216389003860	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
216389003861	substrate binding site [polypeptide binding]; other site
216389003862	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
216389003863	Zn binding sites [ion binding]; other site
216389003864	dimer interface [polypeptide binding]; other site
216389003865	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
216389003866	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
216389003867	nucleotide binding site [chemical binding]; other site
216389003868	NEF interaction site [polypeptide binding]; other site
216389003869	SBD interface [polypeptide binding]; other site
216389003870	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
216389003871	dimer interface [polypeptide binding]; other site
216389003872	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
216389003873	heat shock gene repressor HrcA; Region: hrcA; TIGR00331
216389003874	HrcA protein C terminal domain; Region: HrcA; pfam01628
216389003875	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
216389003876	Caspase domain; Region: Peptidase_C14; pfam00656
216389003877	Peptidase C13 family; Region: Peptidase_C13; cl02159
216389003878	RNase_H superfamily; Region: RNase_H_2; pfam13482
216389003879	active site
216389003880	catalytic site [active]
216389003881	substrate binding site [chemical binding]; other site
216389003882	active site
216389003883	substrate binding site [chemical binding]; other site
216389003884	catalytic site [active]
216389003885	transcription termination factor Rho; Provisional; Region: rho; PRK09376
216389003886	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
216389003887	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
216389003888	RNA binding site [nucleotide binding]; other site
216389003889	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
216389003890	Walker A motif; other site
216389003891	ATP binding site [chemical binding]; other site
216389003892	Walker B motif; other site
216389003893	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
216389003894	active site
216389003895	intersubunit interactions; other site
216389003896	catalytic residue [active]
216389003897	CTP synthetase; Validated; Region: pyrG; PRK05380
216389003898	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
216389003899	Catalytic site [active]
216389003900	active site
216389003901	UTP binding site [chemical binding]; other site
216389003902	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
216389003903	active site
216389003904	putative oxyanion hole; other site
216389003905	catalytic triad [active]
216389003906	chaperone protein DnaJ; Provisional; Region: PRK10767
216389003907	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
216389003908	HSP70 interaction site [polypeptide binding]; other site
216389003909	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
216389003910	substrate binding site [polypeptide binding]; other site
216389003911	dimer interface [polypeptide binding]; other site
216389003912	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
216389003913	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
216389003914	DNA binding residues [nucleotide binding]
216389003915	putative dimer interface [polypeptide binding]; other site
216389003916	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
216389003917	Clp amino terminal domain; Region: Clp_N; pfam02861
216389003918	Clp amino terminal domain; Region: Clp_N; pfam02861
216389003919	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216389003920	Walker A motif; other site
216389003921	ATP binding site [chemical binding]; other site
216389003922	Walker B motif; other site
216389003923	arginine finger; other site
216389003924	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216389003925	Walker A motif; other site
216389003926	ATP binding site [chemical binding]; other site
216389003927	Walker B motif; other site
216389003928	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
216389003929	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
216389003930	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
216389003931	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
216389003932	active site
216389003933	tetramer interface [polypeptide binding]; other site
216389003934	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
216389003935	active site
216389003936	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
216389003937	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
216389003938	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
216389003939	dimerization interface [polypeptide binding]; other site
216389003940	putative ATP binding site [chemical binding]; other site
216389003941	Methyltransferase domain; Region: Methyltransf_31; pfam13847
216389003942	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216389003943	S-adenosylmethionine binding site [chemical binding]; other site
216389003944	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
216389003945	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
216389003946	purine monophosphate binding site [chemical binding]; other site
216389003947	dimer interface [polypeptide binding]; other site
216389003948	putative catalytic residues [active]
216389003949	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
216389003950	nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662
216389003951	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
216389003952	active site
216389003953	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
216389003954	arsenite S-adenosylmethyltransferase; Reviewed; Region: arsM; PRK11873
216389003955	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216389003956	S-adenosylmethionine binding site [chemical binding]; other site
216389003957	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
216389003958	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
216389003959	Ligand Binding Site [chemical binding]; other site
216389003960	TilS substrate C-terminal domain; Region: TilS_C; smart00977
216389003961	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
216389003962	catalytic core [active]
216389003963	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216389003964	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
216389003965	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
216389003966	Domain of unknown function DUF21; Region: DUF21; pfam01595
216389003967	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
216389003968	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
216389003969	Transporter associated domain; Region: CorC_HlyC; smart01091
216389003970	UGMP family protein; Validated; Region: PRK09604
216389003971	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
216389003972	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
216389003973	oligomerisation interface [polypeptide binding]; other site
216389003974	mobile loop; other site
216389003975	roof hairpin; other site
216389003976	chaperonin GroEL; Reviewed; Region: groEL; PRK12850
216389003977	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
216389003978	ring oligomerisation interface [polypeptide binding]; other site
216389003979	ATP/Mg binding site [chemical binding]; other site
216389003980	stacking interactions; other site
216389003981	hinge regions; other site
216389003982	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
216389003983	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
216389003984	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
216389003985	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
216389003986	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
216389003987	Acylphosphatase; Region: Acylphosphatase; pfam00708
216389003988	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
216389003989	HypF finger; Region: zf-HYPF; pfam07503
216389003990	HypF finger; Region: zf-HYPF; pfam07503
216389003991	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
216389003992	HupF/HypC family; Region: HupF_HypC; pfam01455
216389003993	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
216389003994	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
216389003995	dimerization interface [polypeptide binding]; other site
216389003996	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
216389003997	ATP binding site [chemical binding]; other site
216389003998	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216389003999	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216389004000	glyceraldehyde-3-phosphate dehydrogenase B; Region: PLN02237
216389004001	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
216389004002	DNA binding residues [nucleotide binding]
216389004003	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
216389004004	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824
216389004005	putative hydrophobic ligand binding site [chemical binding]; other site
216389004006	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
216389004007	putative active site pocket [active]
216389004008	dimerization interface [polypeptide binding]; other site
216389004009	putative catalytic residue [active]
216389004010	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
216389004011	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
216389004012	5S rRNA interface [nucleotide binding]; other site
216389004013	CTC domain interface [polypeptide binding]; other site
216389004014	L16 interface [polypeptide binding]; other site
216389004015	Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693
216389004016	Amidohydrolase; Region: Amidohydro_2; pfam04909
216389004017	active site
216389004018	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
216389004019	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
216389004020	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
216389004021	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
216389004022	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
216389004023	active site
216389004024	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
216389004025	30S subunit binding site; other site
216389004026	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
216389004027	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
216389004028	DNA binding site [nucleotide binding]
216389004029	active site
216389004030	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394
216389004031	hypothetical protein; Reviewed; Region: PRK00024
216389004032	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066
216389004033	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
216389004034	helix-hairpin-helix signature motif; other site
216389004035	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
216389004036	MPN+ (JAMM) motif; other site
216389004037	Zinc-binding site [ion binding]; other site
216389004038	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
216389004039	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826
216389004040	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
216389004041	active site
216389004042	PHP Thumb interface [polypeptide binding]; other site
216389004043	metal binding site [ion binding]; metal-binding site
216389004044	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
216389004045	Helix-hairpin-helix motif; Region: HHH_6; pfam14579
216389004046	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
216389004047	generic binding surface II; other site
216389004048	generic binding surface I; other site
216389004049	Protein of unknown function (DUF1461); Region: DUF1461; cl01862
216389004050	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
216389004051	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
216389004052	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
216389004053	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
216389004054	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
216389004055	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
216389004056	glutamine binding [chemical binding]; other site
216389004057	catalytic triad [active]
216389004058	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
216389004059	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
216389004060	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
216389004061	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
216389004062	active site
216389004063	ribulose/triose binding site [chemical binding]; other site
216389004064	phosphate binding site [ion binding]; other site
216389004065	substrate (anthranilate) binding pocket [chemical binding]; other site
216389004066	product (indole) binding pocket [chemical binding]; other site
216389004067	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
216389004068	active site
216389004069	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
216389004070	DAHP synthetase I family; Region: DAHP_synth_1; cl17225
216389004071	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
216389004072	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216389004073	catalytic residue [active]
216389004074	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
216389004075	substrate binding site [chemical binding]; other site
216389004076	active site
216389004077	catalytic residues [active]
216389004078	heterodimer interface [polypeptide binding]; other site
216389004079	Thymidylate synthase complementing protein; Region: Thy1; pfam02511
216389004080	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
216389004081	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
216389004082	Walker A/P-loop; other site
216389004083	ATP binding site [chemical binding]; other site
216389004084	Q-loop/lid; other site
216389004085	ABC transporter signature motif; other site
216389004086	Walker B; other site
216389004087	D-loop; other site
216389004088	H-loop/switch region; other site
216389004089	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
216389004090	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
216389004091	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
216389004092	Walker A/P-loop; other site
216389004093	ATP binding site [chemical binding]; other site
216389004094	Q-loop/lid; other site
216389004095	ABC transporter signature motif; other site
216389004096	Walker B; other site
216389004097	D-loop; other site
216389004098	H-loop/switch region; other site
216389004099	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
216389004100	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
216389004101	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216389004102	dimer interface [polypeptide binding]; other site
216389004103	conserved gate region; other site
216389004104	putative PBP binding loops; other site
216389004105	ABC-ATPase subunit interface; other site
216389004106	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
216389004107	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216389004108	dimer interface [polypeptide binding]; other site
216389004109	conserved gate region; other site
216389004110	putative PBP binding loops; other site
216389004111	ABC-ATPase subunit interface; other site
216389004112	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
216389004113	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
216389004114	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
216389004115	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216389004116	S-adenosylmethionine binding site [chemical binding]; other site
216389004117	Transcriptional regulators [Transcription]; Region: MarR; COG1846
216389004118	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
216389004119	dimerization interface [polypeptide binding]; other site
216389004120	putative Zn2+ binding site [ion binding]; other site
216389004121	putative DNA binding site [nucleotide binding]; other site
216389004122	camphor resistance protein CrcB; Provisional; Region: PRK14212
216389004123	Predicted transcriptional regulator [Transcription]; Region: COG1497
216389004124	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
216389004125	non-specific DNA interactions [nucleotide binding]; other site
216389004126	DNA binding site [nucleotide binding]
216389004127	sequence specific DNA binding site [nucleotide binding]; other site
216389004128	putative cAMP binding site [chemical binding]; other site
216389004129	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
216389004130	Flavodoxins [Energy production and conversion]; Region: FldA; COG0716
216389004131	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216389004132	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216389004133	putative substrate translocation pore; other site
216389004134	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
216389004135	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
216389004136	G1 box; other site
216389004137	GTP/Mg2+ binding site [chemical binding]; other site
216389004138	Switch I region; other site
216389004139	G2 box; other site
216389004140	G3 box; other site
216389004141	Switch II region; other site
216389004142	G4 box; other site
216389004143	G5 box; other site
216389004144	Nucleoside recognition; Region: Gate; pfam07670
216389004145	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
216389004146	Nucleoside recognition; Region: Gate; pfam07670
216389004147	FeoA domain; Region: FeoA; pfam04023
216389004148	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
216389004149	metal binding site 2 [ion binding]; metal-binding site
216389004150	putative DNA binding helix; other site
216389004151	metal binding site 1 [ion binding]; metal-binding site
216389004152	dimer interface [polypeptide binding]; other site
216389004153	structural Zn2+ binding site [ion binding]; other site
216389004154	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
216389004155	SmpB-tmRNA interface; other site
216389004156	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
216389004157	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
216389004158	catalytic residues [active]
216389004159	catalytic nucleophile [active]
216389004160	Recombinase; Region: Recombinase; pfam07508
216389004161	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
216389004162	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
216389004163	Resolvase, N terminal domain; Region: Resolvase; smart00857
216389004164	catalytic residues [active]
216389004165	Transposase; Region: HTH_Tnp_1; pfam01527
216389004166	HTH-like domain; Region: HTH_21; pfam13276
216389004167	Integrase core domain; Region: rve; pfam00665
216389004168	Integrase core domain; Region: rve_3; pfam13683
216389004169	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
216389004170	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
216389004171	Prephenate dehydratase; Region: PDT; pfam00800
216389004172	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
216389004173	putative L-Phe binding site [chemical binding]; other site
216389004174	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
216389004175	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
216389004176	GatB domain; Region: GatB_Yqey; smart00845
216389004177	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
216389004178	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
216389004179	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
216389004180	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
216389004181	DNA binding residues [nucleotide binding]
216389004182	Prenyltransferase-like; Region: Prenyltrans_1; pfam13243
216389004183	Pectic acid lyase; Region: Pec_lyase; cl19904
216389004184	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
216389004185	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl19197
216389004186	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
216389004187	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl19174
216389004188	hydrogenase membrane subunit; Validated; Region: PRK08676
216389004189	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
216389004190	Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899
216389004191	NADH dehydrogenase; Region: NADHdh; cl00469
216389004192	hydrogenase membrane subunit; Validated; Region: PRK08667
216389004193	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
216389004194	methylglyoxal synthase; Validated; Region: mgsA; PRK05234
216389004195	substrate binding site [chemical binding]; other site
216389004196	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
216389004197	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
216389004198	Mechanosensitive ion channel; Region: MS_channel; pfam00924
216389004199	HTH-like domain; Region: HTH_21; pfam13276
216389004200	Integrase core domain; Region: rve; pfam00665
216389004201	DDE domain; Region: DDE_Tnp_IS240; pfam13610
216389004202	Integrase core domain; Region: rve_3; pfam13683
216389004203	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
216389004204	Transposase; Region: HTH_Tnp_1; cl17663
216389004205	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216389004206	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216389004207	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
216389004208	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
216389004209	putative NADP binding site [chemical binding]; other site
216389004210	putative substrate binding site [chemical binding]; other site
216389004211	active site
216389004212	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
216389004213	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216389004214	NAD(P) binding site [chemical binding]; other site
216389004215	active site
216389004216	peroxiredoxin; Provisional; Region: PRK13189
216389004217	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
216389004218	dimer interface [polypeptide binding]; other site
216389004219	decamer (pentamer of dimers) interface [polypeptide binding]; other site
216389004220	catalytic triad [active]
216389004221	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
216389004222	putative DNA binding site [nucleotide binding]; other site
216389004223	putative Zn2+ binding site [ion binding]; other site
216389004224	Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453
216389004225	Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453
216389004226	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
216389004227	Peptidase family M48; Region: Peptidase_M48; cl12018
216389004228	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
216389004229	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
216389004230	trimer interface [polypeptide binding]; other site
216389004231	active site
216389004232	substrate binding site [chemical binding]; other site
216389004233	CoA binding site [chemical binding]; other site
216389004234	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
216389004235	Quinolinate synthetase A protein; Region: NadA; pfam02445
216389004236	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
216389004237	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216389004238	S-adenosylmethionine binding site [chemical binding]; other site
216389004239	AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061
216389004240	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309
216389004241	dimerization interface [polypeptide binding]; other site
216389004242	putative ATP binding site [chemical binding]; other site
216389004243	Predicted transcriptional regulator [Transcription]; Region: COG1959
216389004244	Rrf2 family protein; Region: rrf2_super; TIGR00738
216389004245	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
216389004246	ApbE family; Region: ApbE; pfam02424
216389004247	FMN-binding domain; Region: FMN_bind; pfam04205
216389004248	4Fe-4S binding domain; Region: Fer4_5; pfam12801
216389004249	FMN-binding domain; Region: FMN_bind; pfam04205
216389004250	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
216389004251	4Fe-4S binding domain; Region: Fer4_5; pfam12801
216389004252	4Fe-4S binding domain; Region: Fer4_5; pfam12801
216389004253	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
216389004254	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
216389004255	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
216389004256	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
216389004257	Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294
216389004258	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
216389004259	substrate binding pocket [chemical binding]; other site
216389004260	dimer interface [polypeptide binding]; other site
216389004261	inhibitor binding site; inhibition site
216389004262	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
216389004263	catalytic center binding site [active]
216389004264	ATP binding site [chemical binding]; other site
216389004265	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
216389004266	active site
216389004267	recombinase A; Provisional; Region: recA; PRK09354
216389004268	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
216389004269	hexamer interface [polypeptide binding]; other site
216389004270	Walker A motif; other site
216389004271	ATP binding site [chemical binding]; other site
216389004272	Walker B motif; other site
216389004273	recombination regulator RecX; Reviewed; Region: recX; PRK00117
216389004274	ribonuclease Y; Region: RNase_Y; TIGR03319
216389004275	KH domain; Region: KH_1; pfam00013
216389004276	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
216389004277	Zn2+ binding site [ion binding]; other site
216389004278	Mg2+ binding site [ion binding]; other site
216389004279	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
216389004280	putative active site [active]
216389004281	metal binding site [ion binding]; metal-binding site
216389004282	homodimer binding site [polypeptide binding]; other site
216389004283	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
216389004284	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
216389004285	active site
216389004286	membrane protein; Provisional; Region: PRK14417
216389004287	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
216389004288	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
216389004289	minor groove reading motif; other site
216389004290	helix-hairpin-helix signature motif; other site
216389004291	substrate binding pocket [chemical binding]; other site
216389004292	active site
216389004293	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
216389004294	homodimer interaction site [polypeptide binding]; other site
216389004295	cofactor binding site; other site
216389004296	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
216389004297	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962
216389004298	active site
216389004299	catalytic residues [active]
216389004300	metal binding site [ion binding]; metal-binding site
216389004301	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
216389004302	nucleotide binding site/active site [active]
216389004303	HIT family signature motif; other site
216389004304	catalytic residue [active]
216389004305	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
216389004306	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
216389004307	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
216389004308	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
216389004309	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
216389004310	Walker A/P-loop; other site
216389004311	ATP binding site [chemical binding]; other site
216389004312	Q-loop/lid; other site
216389004313	ABC transporter signature motif; other site
216389004314	Walker B; other site
216389004315	D-loop; other site
216389004316	H-loop/switch region; other site
216389004317	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
216389004318	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
216389004319	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
216389004320	Bacterial PH domain; Region: bPH_2; cl01348
216389004321	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
216389004322	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
216389004323	trimer interface [polypeptide binding]; other site
216389004324	putative Zn binding site [ion binding]; other site
216389004325	Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974
216389004326	non-heme iron binding site [ion binding]; other site
216389004327	dimer interface [polypeptide binding]; other site
216389004328	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
216389004329	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
216389004330	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935
216389004331	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
216389004332	putative cation:proton antiport protein; Provisional; Region: PRK10669
216389004333	TrkA-N domain; Region: TrkA_N; pfam02254
216389004334	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
216389004335	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
216389004336	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
216389004337	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216389004338	FeS/SAM binding site; other site
216389004339	DNA gyrase subunit A; Validated; Region: PRK05560
216389004340	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
216389004341	CAP-like domain; other site
216389004342	active site
216389004343	primary dimer interface [polypeptide binding]; other site
216389004344	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
216389004345	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
216389004346	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
216389004347	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
216389004348	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
216389004349	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
216389004350	binding surface
216389004351	Tetratricopeptide repeat; Region: TPR_16; pfam13432
216389004352	TPR motif; other site
216389004353	NifU-like domain; Region: NifU; cl00484
216389004354	aspartate kinase; Reviewed; Region: PRK06635
216389004355	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
216389004356	putative nucleotide binding site [chemical binding]; other site
216389004357	putative catalytic residues [active]
216389004358	putative Mg ion binding site [ion binding]; other site
216389004359	putative aspartate binding site [chemical binding]; other site
216389004360	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
216389004361	putative allosteric regulatory site; other site
216389004362	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
216389004363	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
216389004364	cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200
216389004365	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
216389004366	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
216389004367	homodimer interface [polypeptide binding]; other site
216389004368	metal binding site [ion binding]; metal-binding site
216389004369	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
216389004370	homodimer interface [polypeptide binding]; other site
216389004371	active site
216389004372	putative chemical substrate binding site [chemical binding]; other site
216389004373	metal binding site [ion binding]; metal-binding site
216389004374	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
216389004375	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
216389004376	LexA repressor; Validated; Region: PRK00215
216389004377	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
216389004378	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
216389004379	Catalytic site [active]
216389004380	L-fuculose phosphate aldolase; Provisional; Region: PRK08660
216389004381	intersubunit interface [polypeptide binding]; other site
216389004382	active site
216389004383	Zn2+ binding site [ion binding]; other site
216389004384	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
216389004385	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
216389004386	putative active site [active]
216389004387	substrate binding site [chemical binding]; other site
216389004388	putative cosubstrate binding site; other site
216389004389	catalytic site [active]
216389004390	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
216389004391	substrate binding site [chemical binding]; other site