-- dump date 20140619_055834 -- class Genbank::misc_feature -- table misc_feature_note -- id note 255470000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 255470000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 255470000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 255470000004 Walker A motif; other site 255470000005 ATP binding site [chemical binding]; other site 255470000006 arginine finger; other site 255470000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 255470000008 DnaA box-binding interface [nucleotide binding]; other site 255470000009 GTPase CgtA; Reviewed; Region: obgE; PRK12297 255470000010 GTP1/OBG; Region: GTP1_OBG; pfam01018 255470000011 Obg GTPase; Region: Obg; cd01898 255470000012 G1 box; other site 255470000013 GTP/Mg2+ binding site [chemical binding]; other site 255470000014 Switch I region; other site 255470000015 G2 box; other site 255470000016 G3 box; other site 255470000017 Switch II region; other site 255470000018 G4 box; other site 255470000019 G5 box; other site 255470000020 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 255470000021 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 255470000022 active site 255470000023 (T/H)XGH motif; other site 255470000024 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 255470000025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 255470000026 ATP binding site [chemical binding]; other site 255470000027 Mg2+ binding site [ion binding]; other site 255470000028 G-X-G motif; other site 255470000029 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 255470000030 anchoring element; other site 255470000031 dimer interface [polypeptide binding]; other site 255470000032 ATP binding site [chemical binding]; other site 255470000033 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 255470000034 active site 255470000035 putative metal-binding site [ion binding]; other site 255470000036 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 255470000037 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 255470000038 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 255470000039 Zn2+ binding site [ion binding]; other site 255470000040 Mg2+ binding site [ion binding]; other site 255470000041 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 255470000042 synthetase active site [active] 255470000043 NTP binding site [chemical binding]; other site 255470000044 metal binding site [ion binding]; metal-binding site 255470000045 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 255470000046 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 255470000047 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 255470000048 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 255470000049 dimer interface [polypeptide binding]; other site 255470000050 motif 1; other site 255470000051 active site 255470000052 motif 2; other site 255470000053 motif 3; other site 255470000054 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 255470000055 anticodon binding site; other site 255470000056 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 255470000057 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 255470000058 membrane protein; Provisional; Region: PRK14416 255470000059 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 255470000060 homodimer interface [polypeptide binding]; other site 255470000061 substrate-cofactor binding pocket; other site 255470000062 catalytic residue [active] 255470000063 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 255470000064 active site 255470000065 DNA polymerase IV; Validated; Region: PRK02406 255470000066 DNA binding site [nucleotide binding] 255470000067 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 255470000068 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 255470000069 active site 255470000070 dimer interface [polypeptide binding]; other site 255470000071 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 255470000072 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 255470000073 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 255470000074 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 255470000075 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 255470000076 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 255470000077 putative active site [active] 255470000078 dimerization interface [polypeptide binding]; other site 255470000079 putative tRNAtyr binding site [nucleotide binding]; other site 255470000080 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 255470000081 metal binding site 2 [ion binding]; metal-binding site 255470000082 putative DNA binding helix; other site 255470000083 metal binding site 1 [ion binding]; metal-binding site 255470000084 dimer interface [polypeptide binding]; other site 255470000085 structural Zn2+ binding site [ion binding]; other site 255470000086 Pleckstrin homology-like domain; Region: PH-like; cl17171 255470000087 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 255470000088 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 255470000089 Competence protein; Region: Competence; pfam03772 255470000090 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 255470000091 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 255470000092 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 255470000093 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 255470000094 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 255470000095 TrkA-N domain; Region: TrkA_N; pfam02254 255470000096 TrkA-C domain; Region: TrkA_C; pfam02080 255470000097 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 255470000098 TrkA-N domain; Region: TrkA_N; pfam02254 255470000099 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 255470000100 Ligand Binding Site [chemical binding]; other site 255470000101 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 255470000102 Cation transport protein; Region: TrkH; cl17365 255470000103 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 255470000104 TrkA-N domain; Region: TrkA_N; pfam02254 255470000105 TrkA-C domain; Region: TrkA_C; pfam02080 255470000106 TrkA-N domain; Region: TrkA_N; pfam02254 255470000107 TrkA-C domain; Region: TrkA_C; pfam02080 255470000108 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 255470000109 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 255470000110 TIGR00153 family protein; Region: TIGR00153 255470000111 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 255470000112 Guanylate kinase; Region: Guanylate_kin; pfam00625 255470000113 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 255470000114 catalytic site [active] 255470000115 G-X2-G-X-G-K; other site 255470000116 hypothetical protein; Provisional; Region: PRK04323 255470000117 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 255470000118 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 255470000119 FAD binding pocket [chemical binding]; other site 255470000120 FAD binding motif [chemical binding]; other site 255470000121 phosphate binding motif [ion binding]; other site 255470000122 beta-alpha-beta structure motif; other site 255470000123 NAD binding pocket [chemical binding]; other site 255470000124 Iron coordination center [ion binding]; other site 255470000125 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 255470000126 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 255470000127 SnoaL-like domain; Region: SnoaL_3; pfam13474 255470000128 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 255470000129 S-adenosylmethionine binding site [chemical binding]; other site 255470000130 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 255470000131 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 255470000132 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 255470000133 GTP-binding protein YchF; Reviewed; Region: PRK09601 255470000134 YchF GTPase; Region: YchF; cd01900 255470000135 G1 box; other site 255470000136 GTP/Mg2+ binding site [chemical binding]; other site 255470000137 Switch I region; other site 255470000138 G2 box; other site 255470000139 Switch II region; other site 255470000140 G3 box; other site 255470000141 G4 box; other site 255470000142 G5 box; other site 255470000143 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 255470000144 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912 255470000145 DNA polymerase III, delta subunit; Region: holA; TIGR01128 255470000146 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 255470000147 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 255470000148 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 255470000149 nucleotide binding site [chemical binding]; other site 255470000150 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 255470000151 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 255470000152 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 255470000153 motif 1; other site 255470000154 active site 255470000155 motif 2; other site 255470000156 motif 3; other site 255470000157 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 255470000158 FlxA-like protein; Region: FlxA; pfam14282 255470000159 DHHA1 domain; Region: DHHA1; pfam02272 255470000160 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 255470000161 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 255470000162 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 255470000163 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 255470000164 active site 255470000165 NAD binding site [chemical binding]; other site 255470000166 metal binding site [ion binding]; metal-binding site 255470000167 Clp protease ATP binding subunit; Region: clpC; CHL00095 255470000168 Clp amino terminal domain; Region: Clp_N; pfam02861 255470000169 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 255470000170 Walker A motif; other site 255470000171 ATP binding site [chemical binding]; other site 255470000172 Walker B motif; other site 255470000173 arginine finger; other site 255470000174 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 255470000175 Walker A motif; other site 255470000176 ATP binding site [chemical binding]; other site 255470000177 Walker B motif; other site 255470000178 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 255470000179 DNA repair protein RadA; Provisional; Region: PRK11823 255470000180 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 255470000181 Walker A motif/ATP binding site; other site 255470000182 ATP binding site [chemical binding]; other site 255470000183 Walker B motif; other site 255470000184 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 255470000185 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 255470000186 substrate binding site; other site 255470000187 dimer interface; other site 255470000188 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 255470000189 homotrimer interaction site [polypeptide binding]; other site 255470000190 zinc binding site [ion binding]; other site 255470000191 CDP-binding sites; other site 255470000192 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 255470000193 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 255470000194 active site 255470000195 HIGH motif; other site 255470000196 KMSKS motif; other site 255470000197 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 255470000198 tRNA binding surface [nucleotide binding]; other site 255470000199 anticodon binding site; other site 255470000200 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 255470000201 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 255470000202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 255470000203 active site 255470000204 phosphorylation site [posttranslational modification] 255470000205 intermolecular recognition site; other site 255470000206 dimerization interface [polypeptide binding]; other site 255470000207 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 255470000208 DNA binding site [nucleotide binding] 255470000209 PAS domain; Region: PAS; smart00091 255470000210 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 255470000211 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 255470000212 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470000213 putative active site [active] 255470000214 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 255470000215 phosphorylation site [posttranslational modification] 255470000216 dimer interface [polypeptide binding]; other site 255470000217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 255470000218 ATP binding site [chemical binding]; other site 255470000219 Mg2+ binding site [ion binding]; other site 255470000220 G-X-G motif; other site 255470000221 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 255470000222 reductive dehalogenase; Region: RDH; TIGR02486 255470000223 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 255470000224 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 255470000225 PAS domain S-box; Region: sensory_box; TIGR00229 255470000226 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470000227 putative active site [active] 255470000228 heme pocket [chemical binding]; other site 255470000229 PAS domain S-box; Region: sensory_box; TIGR00229 255470000230 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470000231 putative active site [active] 255470000232 heme pocket [chemical binding]; other site 255470000233 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 255470000234 dimer interface [polypeptide binding]; other site 255470000235 phosphorylation site [posttranslational modification] 255470000236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 255470000237 ATP binding site [chemical binding]; other site 255470000238 Mg2+ binding site [ion binding]; other site 255470000239 G-X-G motif; other site 255470000240 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 255470000241 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 255470000242 active site 255470000243 phosphorylation site [posttranslational modification] 255470000244 intermolecular recognition site; other site 255470000245 dimerization interface [polypeptide binding]; other site 255470000246 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 255470000247 DNA binding site [nucleotide binding] 255470000248 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 255470000249 reductive dehalogenase; Region: RDH; TIGR02486 255470000250 Glycine zipper; Region: Gly-zipper_Omp; pfam13488 255470000251 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 255470000252 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 255470000253 reductive dehalogenase; Region: RDH; TIGR02486 255470000254 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 255470000255 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 255470000256 Ligand Binding Site [chemical binding]; other site 255470000257 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 255470000258 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 255470000259 active site 255470000260 phosphorylation site [posttranslational modification] 255470000261 intermolecular recognition site; other site 255470000262 dimerization interface [polypeptide binding]; other site 255470000263 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 255470000264 DNA binding site [nucleotide binding] 255470000265 PAS domain S-box; Region: sensory_box; TIGR00229 255470000266 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470000267 putative active site [active] 255470000268 heme pocket [chemical binding]; other site 255470000269 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 255470000270 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 255470000271 dimer interface [polypeptide binding]; other site 255470000272 phosphorylation site [posttranslational modification] 255470000273 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 255470000274 ATP binding site [chemical binding]; other site 255470000275 Mg2+ binding site [ion binding]; other site 255470000276 G-X-G motif; other site 255470000277 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 255470000278 B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013 255470000279 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 255470000280 FeS/SAM binding site; other site 255470000281 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 255470000282 FeS/SAM binding site; other site 255470000283 Radical SAM superfamily; Region: Radical_SAM; pfam04055 255470000284 Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102 255470000285 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 255470000286 Ligand Binding Site [chemical binding]; other site 255470000287 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 255470000288 reductive dehalogenase; Region: RDH; TIGR02486 255470000289 4Fe-4S binding domain; Region: Fer4; pfam00037 255470000290 Putative zinc- or iron-chelating domain; Region: CxxCxxCC; pfam03692 255470000291 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470000292 PAS domain; Region: PAS_9; pfam13426 255470000293 Histidine kinase; Region: HisKA_3; pfam07730 255470000294 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 255470000295 ATP binding site [chemical binding]; other site 255470000296 Mg2+ binding site [ion binding]; other site 255470000297 G-X-G motif; other site 255470000298 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 255470000299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 255470000300 active site 255470000301 phosphorylation site [posttranslational modification] 255470000302 intermolecular recognition site; other site 255470000303 dimerization interface [polypeptide binding]; other site 255470000304 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 255470000305 DNA binding residues [nucleotide binding] 255470000306 dimerization interface [polypeptide binding]; other site 255470000307 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 255470000308 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 255470000309 non-specific DNA binding site [nucleotide binding]; other site 255470000310 salt bridge; other site 255470000311 sequence-specific DNA binding site [nucleotide binding]; other site 255470000312 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 255470000313 Piwi_piwi-like_ProArk: PIWI domain, Piwi-like subfamily found in Archaea and Bacteria. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs; Region: Piwi_piwi-like_ProArk; cd04659 255470000314 5' RNA guide strand anchoring site; other site 255470000315 active site 255470000316 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 255470000317 non-specific DNA binding site [nucleotide binding]; other site 255470000318 salt bridge; other site 255470000319 sequence-specific DNA binding site [nucleotide binding]; other site 255470000320 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 255470000321 HsdM N-terminal domain; Region: HsdM_N; pfam12161 255470000322 Methyltransferase domain; Region: Methyltransf_26; pfam13659 255470000323 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 255470000324 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 255470000325 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 255470000326 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 255470000327 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 255470000328 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 255470000329 ATP binding site [chemical binding]; other site 255470000330 putative Mg++ binding site [ion binding]; other site 255470000331 Protein of unknown function DUF45; Region: DUF45; pfam01863 255470000332 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 255470000333 ATP binding site [chemical binding]; other site 255470000334 putative Mg++ binding site [ion binding]; other site 255470000335 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 255470000336 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 255470000337 nucleotide binding region [chemical binding]; other site 255470000338 ATP-binding site [chemical binding]; other site 255470000339 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 255470000340 AAA domain; Region: AAA_11; pfam13086 255470000341 AAA domain; Region: AAA_30; pfam13604 255470000342 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 255470000343 Recombinase; Region: Recombinase; pfam07508 255470000344 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 255470000345 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 255470000346 dinuclear metal binding motif [ion binding]; other site 255470000347 NTPase; Region: NTPase_1; cl17478 255470000348 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 255470000349 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 255470000350 GTP binding site; other site 255470000351 tetrathionate reductase subunit A; Provisional; Region: PRK14991 255470000352 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 255470000353 molybdopterin cofactor binding site; other site 255470000354 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 255470000355 putative molybdopterin cofactor binding site; other site 255470000356 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 255470000357 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 255470000358 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 255470000359 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 255470000360 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 255470000361 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 255470000362 Walker A motif; other site 255470000363 EDD domain protein, DegV family; Region: DegV; TIGR00762 255470000364 E3 Ubiquitin ligase; Region: GIDE; pfam12483 255470000365 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 255470000366 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 255470000367 putative catalytic site [active] 255470000368 putative metal binding site [ion binding]; other site 255470000369 putative phosphate binding site [ion binding]; other site 255470000370 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 255470000371 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 255470000372 putative substrate-binding site; other site 255470000373 nickel binding site [ion binding]; other site 255470000374 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 255470000375 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 255470000376 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 255470000377 NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720 255470000378 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 255470000379 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 255470000380 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 255470000381 ABC-2 type transporter; Region: ABC2_membrane; cl17235 255470000382 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 255470000383 Acyltransferase family; Region: Acyl_transf_3; cl19154 255470000384 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 255470000385 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 255470000386 Walker A/P-loop; other site 255470000387 ATP binding site [chemical binding]; other site 255470000388 Q-loop/lid; other site 255470000389 ABC transporter signature motif; other site 255470000390 Walker B; other site 255470000391 D-loop; other site 255470000392 H-loop/switch region; other site 255470000393 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 255470000394 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 255470000395 DJ-1 family protein; Region: not_thiJ; TIGR01383 255470000396 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 255470000397 conserved cys residue [active] 255470000398 pyruvate carboxylase subunit B; Validated; Region: PRK09282 255470000399 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 255470000400 active site 255470000401 catalytic residues [active] 255470000402 metal binding site [ion binding]; metal-binding site 255470000403 homodimer binding site [polypeptide binding]; other site 255470000404 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 255470000405 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 255470000406 carboxyltransferase (CT) interaction site; other site 255470000407 biotinylation site [posttranslational modification]; other site 255470000408 pyruvate carboxylase subunit A; Validated; Region: PRK08654 255470000409 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 255470000410 ATP-grasp domain; Region: ATP-grasp_4; cl17255 255470000411 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 255470000412 2TM domain; Region: 2TM; pfam13239 255470000413 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 255470000414 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 255470000415 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 255470000416 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 255470000417 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 255470000418 4Fe-4S binding domain; Region: Fer4; pfam00037 255470000419 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 255470000420 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 255470000421 putative NAD(P) binding site [chemical binding]; other site 255470000422 catalytic Zn binding site [ion binding]; other site 255470000423 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 255470000424 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 255470000425 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 255470000426 GAF domain; Region: GAF_2; pfam13185 255470000427 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470000428 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 255470000429 putative active site [active] 255470000430 heme pocket [chemical binding]; other site 255470000431 PAS domain; Region: PAS; smart00091 255470000432 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 255470000433 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470000434 putative active site [active] 255470000435 heme pocket [chemical binding]; other site 255470000436 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 255470000437 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470000438 putative active site [active] 255470000439 heme pocket [chemical binding]; other site 255470000440 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 255470000441 dimer interface [polypeptide binding]; other site 255470000442 phosphorylation site [posttranslational modification] 255470000443 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 255470000444 ATP binding site [chemical binding]; other site 255470000445 Mg2+ binding site [ion binding]; other site 255470000446 G-X-G motif; other site 255470000447 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 255470000448 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 255470000449 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 255470000450 catalytic triad [active] 255470000451 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 255470000452 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 255470000453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 255470000454 active site 255470000455 phosphorylation site [posttranslational modification] 255470000456 intermolecular recognition site; other site 255470000457 dimerization interface [polypeptide binding]; other site 255470000458 Response regulator receiver domain; Region: Response_reg; pfam00072 255470000459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 255470000460 active site 255470000461 phosphorylation site [posttranslational modification] 255470000462 intermolecular recognition site; other site 255470000463 dimerization interface [polypeptide binding]; other site 255470000464 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 255470000465 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 255470000466 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124 255470000467 DNA polymerase, archaeal type II, large subunit; Region: polC; TIGR00354 255470000468 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 255470000469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 255470000470 active site 255470000471 phosphorylation site [posttranslational modification] 255470000472 intermolecular recognition site; other site 255470000473 dimerization interface [polypeptide binding]; other site 255470000474 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 255470000475 DNA binding site [nucleotide binding] 255470000476 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 255470000477 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 255470000478 dimerization interface [polypeptide binding]; other site 255470000479 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470000480 putative active site [active] 255470000481 heme pocket [chemical binding]; other site 255470000482 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 255470000483 dimer interface [polypeptide binding]; other site 255470000484 phosphorylation site [posttranslational modification] 255470000485 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 255470000486 ATP binding site [chemical binding]; other site 255470000487 Mg2+ binding site [ion binding]; other site 255470000488 G-X-G motif; other site 255470000489 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 255470000490 active site 255470000491 dimer interfaces [polypeptide binding]; other site 255470000492 catalytic residues [active] 255470000493 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 255470000494 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 255470000495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 255470000496 dimer interface [polypeptide binding]; other site 255470000497 conserved gate region; other site 255470000498 putative PBP binding loops; other site 255470000499 ABC-ATPase subunit interface; other site 255470000500 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 255470000501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 255470000502 dimer interface [polypeptide binding]; other site 255470000503 conserved gate region; other site 255470000504 putative PBP binding loops; other site 255470000505 ABC-ATPase subunit interface; other site 255470000506 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14249 255470000507 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 255470000508 Walker A/P-loop; other site 255470000509 ATP binding site [chemical binding]; other site 255470000510 Q-loop/lid; other site 255470000511 ABC transporter signature motif; other site 255470000512 Walker B; other site 255470000513 D-loop; other site 255470000514 H-loop/switch region; other site 255470000515 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 255470000516 PhoU domain; Region: PhoU; pfam01895 255470000517 PhoU domain; Region: PhoU; pfam01895 255470000518 Low molecular weight phosphatase family; Region: LMWPc; cd00115 255470000519 active site 255470000520 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 255470000521 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 255470000522 putative dimer interface [polypeptide binding]; other site 255470000523 [2Fe-2S] cluster binding site [ion binding]; other site 255470000524 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 255470000525 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 255470000526 SLBB domain; Region: SLBB; pfam10531 255470000527 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 255470000528 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 255470000529 catalytic loop [active] 255470000530 iron binding site [ion binding]; other site 255470000531 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 255470000532 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 255470000533 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 255470000534 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 255470000535 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; smart00902 255470000536 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 255470000537 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 255470000538 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 255470000539 Protein of unknown function DUF45; Region: DUF45; pfam01863 255470000540 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 255470000541 EamA-like transporter family; Region: EamA; pfam00892 255470000542 EamA-like transporter family; Region: EamA; pfam00892 255470000543 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 255470000544 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 255470000545 tetramer interface [polypeptide binding]; other site 255470000546 pyridoxal 5'-phosphate binding site [chemical binding]; other site 255470000547 catalytic residue [active] 255470000548 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 255470000549 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 255470000550 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 255470000551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 255470000552 active site 255470000553 phosphorylation site [posttranslational modification] 255470000554 intermolecular recognition site; other site 255470000555 dimerization interface [polypeptide binding]; other site 255470000556 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 255470000557 DNA binding site [nucleotide binding] 255470000558 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 255470000559 dimer interface [polypeptide binding]; other site 255470000560 phosphorylation site [posttranslational modification] 255470000561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 255470000562 ATP binding site [chemical binding]; other site 255470000563 Mg2+ binding site [ion binding]; other site 255470000564 G-X-G motif; other site 255470000565 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 255470000566 reductive dehalogenase; Region: RDH; TIGR02486 255470000567 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 255470000568 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 255470000569 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 255470000570 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 255470000571 ATP binding site [chemical binding]; other site 255470000572 Mg++ binding site [ion binding]; other site 255470000573 motif III; other site 255470000574 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 255470000575 nucleotide binding region [chemical binding]; other site 255470000576 ATP-binding site [chemical binding]; other site 255470000577 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 255470000578 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 255470000579 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 255470000580 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 255470000581 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 255470000582 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 255470000583 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 255470000584 [4Fe-4S] binding site [ion binding]; other site 255470000585 molybdopterin cofactor binding site; other site 255470000586 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 255470000587 molybdopterin cofactor binding site; other site 255470000588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 255470000589 S-adenosylmethionine binding site [chemical binding]; other site 255470000590 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 255470000591 active site 255470000592 (T/H)XGH motif; other site 255470000593 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 255470000594 Colicin V production protein; Region: Colicin_V; pfam02674 255470000595 pyrroline-5-carboxylate reductase; Region: PLN02688 255470000596 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 255470000597 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 255470000598 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 255470000599 active site 255470000600 HIGH motif; other site 255470000601 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 255470000602 KMSKS motif; other site 255470000603 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 255470000604 tRNA binding surface [nucleotide binding]; other site 255470000605 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 255470000606 HI0933-like protein; Region: HI0933_like; pfam03486 255470000607 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 255470000608 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 255470000609 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 255470000610 catalytic residues [active] 255470000611 Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977 255470000612 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 255470000613 Rubrerythrin [Energy production and conversion]; Region: COG1592 255470000614 iron binding site [ion binding]; other site 255470000615 Protein of unknown function (DUF1616); Region: DUF1616; pfam07760 255470000616 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 255470000617 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 255470000618 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 255470000619 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 255470000620 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 255470000621 active site 255470000622 catalytic tetrad [active] 255470000623 Predicted DNA-binding proteins [General function prediction only]; Region: COG1342 255470000624 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 255470000625 DNA binding residues [nucleotide binding] 255470000626 HEAT repeats; Region: HEAT_2; pfam13646 255470000627 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 255470000628 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 255470000629 FeS/SAM binding site; other site 255470000630 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 255470000631 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 255470000632 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 255470000633 Coenzyme A binding pocket [chemical binding]; other site 255470000634 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 255470000635 reactive center loop; other site 255470000636 Haemolysin-III related; Region: HlyIII; cl03831 255470000637 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 255470000638 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 255470000639 ABC transporter; Region: ABC_tran_2; pfam12848 255470000640 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 255470000641 flavoprotein, HI0933 family; Region: TIGR00275 255470000642 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 255470000643 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 255470000644 Hydrogenase expression/synthesis hypA family; Region: HypA; cl19201 255470000645 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 255470000646 Double zinc ribbon; Region: DZR; pfam12773 255470000647 TM2 domain; Region: TM2; pfam05154 255470000648 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 255470000649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 255470000650 active site 255470000651 phosphorylation site [posttranslational modification] 255470000652 intermolecular recognition site; other site 255470000653 dimerization interface [polypeptide binding]; other site 255470000654 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 255470000655 DNA binding site [nucleotide binding] 255470000656 PAS domain; Region: PAS_9; pfam13426 255470000657 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470000658 putative active site [active] 255470000659 heme pocket [chemical binding]; other site 255470000660 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 255470000661 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 255470000662 dimer interface [polypeptide binding]; other site 255470000663 phosphorylation site [posttranslational modification] 255470000664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 255470000665 ATP binding site [chemical binding]; other site 255470000666 Mg2+ binding site [ion binding]; other site 255470000667 G-X-G motif; other site 255470000668 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 255470000669 reductive dehalogenase; Region: RDH; TIGR02486 255470000670 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 255470000671 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 255470000672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 255470000673 active site 255470000674 phosphorylation site [posttranslational modification] 255470000675 intermolecular recognition site; other site 255470000676 dimerization interface [polypeptide binding]; other site 255470000677 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 255470000678 DNA binding site [nucleotide binding] 255470000679 PAS domain; Region: PAS_9; pfam13426 255470000680 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 255470000681 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 255470000682 dimer interface [polypeptide binding]; other site 255470000683 phosphorylation site [posttranslational modification] 255470000684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 255470000685 ATP binding site [chemical binding]; other site 255470000686 Mg2+ binding site [ion binding]; other site 255470000687 G-X-G motif; other site 255470000688 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 255470000689 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 255470000690 reductive dehalogenase; Region: RDH; TIGR02486 255470000691 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 255470000692 FMN-binding domain; Region: FMN_bind; pfam04205 255470000693 4Fe-4S binding domain; Region: Fer4_5; pfam12801 255470000694 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 255470000695 Ligand Binding Site [chemical binding]; other site 255470000696 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 255470000697 Radical SAM superfamily; Region: Radical_SAM; pfam04055 255470000698 FeS/SAM binding site; other site 255470000699 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 255470000700 active site 255470000701 putative homodimer interface [polypeptide binding]; other site 255470000702 SAM binding site [chemical binding]; other site 255470000703 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 255470000704 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 255470000705 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 255470000706 Radical SAM superfamily; Region: Radical_SAM; pfam04055 255470000707 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 255470000708 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 255470000709 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 255470000710 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 255470000711 active site 255470000712 dimer interface [polypeptide binding]; other site 255470000713 effector binding site; other site 255470000714 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 255470000715 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 255470000716 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 255470000717 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 255470000718 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 255470000719 catalytic residue [active] 255470000720 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 255470000721 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 255470000722 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 255470000723 intersubunit interface [polypeptide binding]; other site 255470000724 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 255470000725 active site 255470000726 putative homodimer interface [polypeptide binding]; other site 255470000727 SAM binding site [chemical binding]; other site 255470000728 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 255470000729 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 255470000730 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 255470000731 ligand binding site [chemical binding]; other site 255470000732 flexible hinge region; other site 255470000733 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 255470000734 putative switch regulator; other site 255470000735 non-specific DNA interactions [nucleotide binding]; other site 255470000736 DNA binding site [nucleotide binding] 255470000737 sequence specific DNA binding site [nucleotide binding]; other site 255470000738 putative cAMP binding site [chemical binding]; other site 255470000739 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 255470000740 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 255470000741 nucleophile elbow; other site 255470000742 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 255470000743 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 255470000744 HerA helicase [Replication, recombination, and repair]; Region: COG0433 255470000745 HAS barrel domain; Region: HAS-barrel; pfam09378 255470000746 Domain of unknown function DUF87; Region: DUF87; pfam01935 255470000747 NurA nuclease; Region: NurA; smart00933 255470000748 LysE type translocator; Region: LysE; cl00565 255470000749 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 255470000750 active site 255470000751 Zn binding site [ion binding]; other site 255470000752 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 255470000753 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 255470000754 Protein export membrane protein; Region: SecD_SecF; pfam02355 255470000755 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 255470000756 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 255470000757 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 255470000758 metal binding triad [ion binding]; metal-binding site 255470000759 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 255470000760 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 255470000761 Zn2+ binding site [ion binding]; other site 255470000762 Mg2+ binding site [ion binding]; other site 255470000763 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 255470000764 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 255470000765 non-specific DNA binding site [nucleotide binding]; other site 255470000766 salt bridge; other site 255470000767 sequence-specific DNA binding site [nucleotide binding]; other site 255470000768 primosome assembly protein PriA; Validated; Region: PRK05580 255470000769 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 255470000770 ATP binding site [chemical binding]; other site 255470000771 putative Mg++ binding site [ion binding]; other site 255470000772 Trm112p-like protein; Region: Trm112p; cl01066 255470000773 helicase superfamily c-terminal domain; Region: HELICc; smart00490 255470000774 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 255470000775 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 255470000776 MraZ protein; Region: MraZ; pfam02381 255470000777 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 255470000778 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 255470000779 Cell division protein FtsA; Region: FtsA; smart00842 255470000780 Cell division protein FtsA; Region: FtsA; pfam14450 255470000781 cell division protein FtsZ; Validated; Region: PRK09330 255470000782 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 255470000783 nucleotide binding site [chemical binding]; other site 255470000784 SulA interaction site; other site 255470000785 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 255470000786 ATP cone domain; Region: ATP-cone; pfam03477 255470000787 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 255470000788 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 255470000789 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 255470000790 active site 255470000791 dimer interface [polypeptide binding]; other site 255470000792 effector binding site; other site 255470000793 TSCPD domain; Region: TSCPD; pfam12637 255470000794 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 255470000795 Uncharacterized conserved protein [Function unknown]; Region: COG1432 255470000796 LabA_like proteins; Region: LabA_like; cd06167 255470000797 putative metal binding site [ion binding]; other site 255470000798 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 255470000799 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 255470000800 FeS/SAM binding site; other site 255470000801 Yqey-like protein; Region: YqeY; pfam09424 255470000802 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 255470000803 CARDB; Region: CARDB; pfam07705 255470000804 Terminase-like family; Region: Terminase_6; pfam03237 255470000805 Uncharacterized conserved protein [Function unknown]; Region: COG5484 255470000806 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 255470000807 Putative zinc ribbon domain; Region: DUF164; pfam02591 255470000808 Ribonuclease H-like superfamily, including RNase H, HI, HII, HIII, and RNase-like domain IV of spliceosomal protein Prp8; Region: RNase_H_like; cl14782 255470000809 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 255470000810 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 255470000811 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 255470000812 protein binding site [polypeptide binding]; other site 255470000813 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 255470000814 Catalytic dyad [active] 255470000815 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 255470000816 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 255470000817 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 255470000818 dimer interface [polypeptide binding]; other site 255470000819 motif 1; other site 255470000820 active site 255470000821 motif 2; other site 255470000822 motif 3; other site 255470000823 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 255470000824 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 255470000825 putative tRNA-binding site [nucleotide binding]; other site 255470000826 B3/4 domain; Region: B3_4; pfam03483 255470000827 tRNA synthetase B5 domain; Region: B5; pfam03484 255470000828 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 255470000829 dimer interface [polypeptide binding]; other site 255470000830 motif 1; other site 255470000831 motif 3; other site 255470000832 motif 2; other site 255470000833 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 255470000834 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 255470000835 dimer interface [polypeptide binding]; other site 255470000836 substrate binding site [chemical binding]; other site 255470000837 metal binding sites [ion binding]; metal-binding site 255470000838 prolyl-tRNA synthetase; Provisional; Region: PRK09194 255470000839 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 255470000840 dimer interface [polypeptide binding]; other site 255470000841 motif 1; other site 255470000842 active site 255470000843 motif 2; other site 255470000844 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 255470000845 putative deacylase active site [active] 255470000846 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 255470000847 active site 255470000848 motif 3; other site 255470000849 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 255470000850 anticodon binding site; other site 255470000851 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 255470000852 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 255470000853 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 255470000854 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 255470000855 active site 255470000856 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 255470000857 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 255470000858 putative substrate binding region [chemical binding]; other site 255470000859 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 255470000860 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 255470000861 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 255470000862 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 255470000863 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 255470000864 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 255470000865 active site 255470000866 dimer interface [polypeptide binding]; other site 255470000867 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 255470000868 hinge region; other site 255470000869 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 255470000870 putative nucleotide binding site [chemical binding]; other site 255470000871 uridine monophosphate binding site [chemical binding]; other site 255470000872 homohexameric interface [polypeptide binding]; other site 255470000873 elongation factor Ts; Reviewed; Region: tsf; PRK12332 255470000874 UBA/TS-N domain; Region: UBA; pfam00627 255470000875 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 255470000876 rRNA interaction site [nucleotide binding]; other site 255470000877 S8 interaction site; other site 255470000878 putative laminin-1 binding site; other site 255470000879 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 255470000880 putative active site [active] 255470000881 catalytic triad [active] 255470000882 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 255470000883 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 255470000884 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 255470000885 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 255470000886 dimerization interface [polypeptide binding]; other site 255470000887 ATP binding site [chemical binding]; other site 255470000888 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 255470000889 dimerization interface [polypeptide binding]; other site 255470000890 ATP binding site [chemical binding]; other site 255470000891 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 255470000892 active site 255470000893 multimer interface [polypeptide binding]; other site 255470000894 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 255470000895 iron-sulfur cluster [ion binding]; other site 255470000896 [2Fe-2S] cluster binding site [ion binding]; other site 255470000897 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 255470000898 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 255470000899 active site 255470000900 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 255470000901 putative SAM binding site [chemical binding]; other site 255470000902 putative homodimer interface [polypeptide binding]; other site 255470000903 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 255470000904 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 255470000905 active site 255470000906 HIGH motif; other site 255470000907 KMSKS motif; other site 255470000908 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 255470000909 tRNA binding surface [nucleotide binding]; other site 255470000910 anticodon binding site; other site 255470000911 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 255470000912 substrate binding pocket [chemical binding]; other site 255470000913 chain length determination region; other site 255470000914 substrate-Mg2+ binding site; other site 255470000915 catalytic residues [active] 255470000916 aspartate-rich region 1; other site 255470000917 active site lid residues [active] 255470000918 aspartate-rich region 2; other site 255470000919 FtsH Extracellular; Region: FtsH_ext; pfam06480 255470000920 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 255470000921 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 255470000922 Walker A motif; other site 255470000923 ATP binding site [chemical binding]; other site 255470000924 Walker B motif; other site 255470000925 arginine finger; other site 255470000926 Peptidase family M41; Region: Peptidase_M41; pfam01434 255470000927 AP endonuclease family 2; Region: AP2Ec; smart00518 255470000928 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 255470000929 AP (apurinic/apyrimidinic) site pocket; other site 255470000930 DNA interaction; other site 255470000931 Metal-binding active site; metal-binding site 255470000932 Oligomerization domain; Region: Oligomerization; pfam02410 255470000933 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 255470000934 active site 255470000935 multimer interface [polypeptide binding]; other site 255470000936 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 255470000937 Glycoprotease family; Region: Peptidase_M22; pfam00814 255470000938 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 255470000939 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 255470000940 motif II; other site 255470000941 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 255470000942 thiamine monophosphate kinase; Provisional; Region: PRK05731 255470000943 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 255470000944 ATP binding site [chemical binding]; other site 255470000945 dimerization interface [polypeptide binding]; other site 255470000946 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 255470000947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 255470000948 S-adenosylmethionine binding site [chemical binding]; other site 255470000949 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 255470000950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 255470000951 S-adenosylmethionine binding site [chemical binding]; other site 255470000952 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 255470000953 active site 255470000954 NAD binding site [chemical binding]; other site 255470000955 metal binding site [ion binding]; metal-binding site 255470000956 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 255470000957 putative active site [active] 255470000958 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 255470000959 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 255470000960 S-adenosylmethionine binding site [chemical binding]; other site 255470000961 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 255470000962 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 255470000963 active site 255470000964 metal binding site [ion binding]; metal-binding site 255470000965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 255470000966 S-adenosylmethionine binding site [chemical binding]; other site 255470000967 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 255470000968 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 255470000969 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 255470000970 Rubrerythrin [Energy production and conversion]; Region: COG1592 255470000971 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 255470000972 binuclear metal center [ion binding]; other site 255470000973 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 255470000974 iron binding site [ion binding]; other site 255470000975 Ion transport protein; Region: Ion_trans; pfam00520 255470000976 Ion channel; Region: Ion_trans_2; pfam07885 255470000977 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 255470000978 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 255470000979 active site 255470000980 NTP binding site [chemical binding]; other site 255470000981 metal binding triad [ion binding]; metal-binding site 255470000982 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 255470000983 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 255470000984 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 255470000985 Walker A/P-loop; other site 255470000986 ATP binding site [chemical binding]; other site 255470000987 Q-loop/lid; other site 255470000988 ABC transporter signature motif; other site 255470000989 Walker B; other site 255470000990 D-loop; other site 255470000991 H-loop/switch region; other site 255470000992 ABC-2 type transporter; Region: ABC2_membrane; cl17235 255470000993 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 255470000994 hypothetical protein; Provisional; Region: PRK01184 255470000995 AAA domain; Region: AAA_18; pfam13238 255470000996 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 255470000997 catalytic motif [active] 255470000998 Zn binding site [ion binding]; other site 255470000999 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 255470001000 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 255470001001 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 255470001002 trimer interface [polypeptide binding]; other site 255470001003 active site 255470001004 Probable zinc-binding domain; Region: zf-trcl; pfam13451 255470001005 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 255470001006 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 255470001007 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 255470001008 Walker A/P-loop; other site 255470001009 ATP binding site [chemical binding]; other site 255470001010 Q-loop/lid; other site 255470001011 ABC transporter signature motif; other site 255470001012 Walker B; other site 255470001013 D-loop; other site 255470001014 H-loop/switch region; other site 255470001015 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 255470001016 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 255470001017 dimer interface [polypeptide binding]; other site 255470001018 conserved gate region; other site 255470001019 putative PBP binding loops; other site 255470001020 ABC-ATPase subunit interface; other site 255470001021 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 255470001022 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 255470001023 substrate binding pocket [chemical binding]; other site 255470001024 membrane-bound complex binding site; other site 255470001025 hinge residues; other site 255470001026 EDD domain protein, DegV family; Region: DegV; TIGR00762 255470001027 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 255470001028 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 255470001029 oligomer interface [polypeptide binding]; other site 255470001030 metal binding site [ion binding]; metal-binding site 255470001031 metal binding site [ion binding]; metal-binding site 255470001032 putative Cl binding site [ion binding]; other site 255470001033 aspartate ring; other site 255470001034 basic sphincter; other site 255470001035 hydrophobic gate; other site 255470001036 periplasmic entrance; other site 255470001037 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 255470001038 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 255470001039 Mut7-C RNAse domain; Region: Mut7-C; pfam01927 255470001040 putative carbohydrate kinase; Provisional; Region: PRK10565 255470001041 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 255470001042 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 255470001043 putative substrate binding site [chemical binding]; other site 255470001044 putative ATP binding site [chemical binding]; other site 255470001045 pantothenate kinase; Reviewed; Region: PRK13321 255470001046 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 255470001047 Flavoprotein; Region: Flavoprotein; cl19190 255470001048 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 255470001049 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 255470001050 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 255470001051 active site 255470001052 HIGH motif; other site 255470001053 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 255470001054 KMSKS motif; other site 255470001055 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 255470001056 tRNA binding surface [nucleotide binding]; other site 255470001057 anticodon binding site; other site 255470001058 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 255470001059 PAS domain S-box; Region: sensory_box; TIGR00229 255470001060 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470001061 putative active site [active] 255470001062 heme pocket [chemical binding]; other site 255470001063 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 255470001064 Histidine kinase; Region: HisKA_3; pfam07730 255470001065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 255470001066 ATP binding site [chemical binding]; other site 255470001067 Mg2+ binding site [ion binding]; other site 255470001068 G-X-G motif; other site 255470001069 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 255470001070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 255470001071 active site 255470001072 phosphorylation site [posttranslational modification] 255470001073 intermolecular recognition site; other site 255470001074 dimerization interface [polypeptide binding]; other site 255470001075 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 255470001076 DNA binding residues [nucleotide binding] 255470001077 dimerization interface [polypeptide binding]; other site 255470001078 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 255470001079 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 255470001080 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 255470001081 nucleotide binding region [chemical binding]; other site 255470001082 ATP-binding site [chemical binding]; other site 255470001083 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 255470001084 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 255470001085 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 255470001086 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 255470001087 active site 255470001088 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 255470001089 dimer interface [polypeptide binding]; other site 255470001090 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 255470001091 active site 255470001092 glycine-pyridoxal phosphate binding site [chemical binding]; other site 255470001093 folate binding site [chemical binding]; other site 255470001094 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 255470001095 Fe-S cluster binding site [ion binding]; other site 255470001096 active site 255470001097 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 255470001098 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 255470001099 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 255470001100 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 255470001101 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 255470001102 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 255470001103 excinuclease ABC subunit B; Provisional; Region: PRK05298 255470001104 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 255470001105 ATP binding site [chemical binding]; other site 255470001106 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 255470001107 nucleotide binding region [chemical binding]; other site 255470001108 ATP-binding site [chemical binding]; other site 255470001109 Ultra-violet resistance protein B; Region: UvrB; pfam12344 255470001110 UvrB/uvrC motif; Region: UVR; pfam02151 255470001111 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14605 255470001112 RuvA N terminal domain; Region: RuvA_N; pfam01330 255470001113 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 255470001114 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 255470001115 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 255470001116 active site 255470001117 putative DNA-binding cleft [nucleotide binding]; other site 255470001118 dimer interface [polypeptide binding]; other site 255470001119 hypothetical protein; Validated; Region: PRK00110 255470001120 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 255470001121 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 255470001122 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 255470001123 putative dimer interface [polypeptide binding]; other site 255470001124 [2Fe-2S] cluster binding site [ion binding]; other site 255470001125 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 255470001126 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 255470001127 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 255470001128 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 255470001129 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 255470001130 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 255470001131 substrate binding site [chemical binding]; other site 255470001132 ligand binding site [chemical binding]; other site 255470001133 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 255470001134 substrate binding site [chemical binding]; other site 255470001135 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 255470001136 malate dehydrogenase; Reviewed; Region: PRK06223 255470001137 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 255470001138 NAD(P) binding site [chemical binding]; other site 255470001139 dimer interface [polypeptide binding]; other site 255470001140 tetramer (dimer of dimers) interface [polypeptide binding]; other site 255470001141 substrate binding site [chemical binding]; other site 255470001142 fumarate hydratase; Provisional; Region: PRK06246 255470001143 Fumarase C-terminus; Region: Fumerase_C; cl00795 255470001144 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 255470001145 nucleotide binding site/active site [active] 255470001146 catalytic residue [active] 255470001147 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 255470001148 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 255470001149 dimer interface [polypeptide binding]; other site 255470001150 ADP-ribose binding site [chemical binding]; other site 255470001151 active site 255470001152 nudix motif; other site 255470001153 metal binding site [ion binding]; metal-binding site 255470001154 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 255470001155 Coenzyme A binding pocket [chemical binding]; other site 255470001156 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 255470001157 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 255470001158 arogenate dehydrogenase; Region: PLN02256 255470001159 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 255470001160 Chorismate mutase type II; Region: CM_2; smart00830 255470001161 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 255470001162 Prephenate dehydratase; Region: PDT; pfam00800 255470001163 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 255470001164 putative L-Phe binding site [chemical binding]; other site 255470001165 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 255470001166 Tetramer interface [polypeptide binding]; other site 255470001167 active site 255470001168 FMN-binding site [chemical binding]; other site 255470001169 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 255470001170 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 255470001171 hinge; other site 255470001172 active site 255470001173 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 255470001174 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 255470001175 ADP binding site [chemical binding]; other site 255470001176 magnesium binding site [ion binding]; other site 255470001177 putative shikimate binding site; other site 255470001178 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 255470001179 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 255470001180 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 255470001181 shikimate binding site; other site 255470001182 NAD(P) binding site [chemical binding]; other site 255470001183 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 255470001184 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 255470001185 active site 255470001186 catalytic residue [active] 255470001187 dimer interface [polypeptide binding]; other site 255470001188 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 255470001189 active site 255470001190 dimer interface [polypeptide binding]; other site 255470001191 metal binding site [ion binding]; metal-binding site 255470001192 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 255470001193 DAHP synthetase I family; Region: DAHP_synth_1; cl17225 255470001194 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 255470001195 S17 interaction site [polypeptide binding]; other site 255470001196 S8 interaction site; other site 255470001197 16S rRNA interaction site [nucleotide binding]; other site 255470001198 streptomycin interaction site [chemical binding]; other site 255470001199 23S rRNA interaction site [nucleotide binding]; other site 255470001200 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 255470001201 30S ribosomal protein S7; Validated; Region: PRK05302 255470001202 elongation factor G; Reviewed; Region: PRK12739 255470001203 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 255470001204 G1 box; other site 255470001205 putative GEF interaction site [polypeptide binding]; other site 255470001206 GTP/Mg2+ binding site [chemical binding]; other site 255470001207 Switch I region; other site 255470001208 G2 box; other site 255470001209 G3 box; other site 255470001210 Switch II region; other site 255470001211 G4 box; other site 255470001212 G5 box; other site 255470001213 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 255470001214 Elongation Factor G, domain II; Region: EFG_II; pfam14492 255470001215 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 255470001216 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 255470001217 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 255470001218 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 255470001219 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 255470001220 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 255470001221 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 255470001222 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 255470001223 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 255470001224 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 255470001225 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 255470001226 putative translocon binding site; other site 255470001227 protein-rRNA interface [nucleotide binding]; other site 255470001228 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 255470001229 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 255470001230 G-X-X-G motif; other site 255470001231 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 255470001232 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 255470001233 23S rRNA interface [nucleotide binding]; other site 255470001234 5S rRNA interface [nucleotide binding]; other site 255470001235 putative antibiotic binding site [chemical binding]; other site 255470001236 L25 interface [polypeptide binding]; other site 255470001237 L27 interface [polypeptide binding]; other site 255470001238 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 255470001239 23S rRNA interface [nucleotide binding]; other site 255470001240 putative translocon interaction site; other site 255470001241 signal recognition particle (SRP54) interaction site; other site 255470001242 L23 interface [polypeptide binding]; other site 255470001243 trigger factor interaction site; other site 255470001244 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 255470001245 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 255470001246 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 255470001247 RNA binding site [nucleotide binding]; other site 255470001248 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 255470001249 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 255470001250 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 255470001251 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 255470001252 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 255470001253 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 255470001254 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 255470001255 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 255470001256 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 255470001257 5S rRNA interface [nucleotide binding]; other site 255470001258 L27 interface [polypeptide binding]; other site 255470001259 23S rRNA interface [nucleotide binding]; other site 255470001260 L5 interface [polypeptide binding]; other site 255470001261 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 255470001262 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 255470001263 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 255470001264 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 255470001265 23S rRNA binding site [nucleotide binding]; other site 255470001266 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 255470001267 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 255470001268 SecY translocase; Region: SecY; pfam00344 255470001269 adenylate kinase; Reviewed; Region: adk; PRK00279 255470001270 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 255470001271 AMP-binding site [chemical binding]; other site 255470001272 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 255470001273 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 255470001274 active site 255470001275 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 255470001276 rRNA binding site [nucleotide binding]; other site 255470001277 predicted 30S ribosome binding site; other site 255470001278 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 255470001279 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 255470001280 30S ribosomal protein S13; Region: bact_S13; TIGR03631 255470001281 30S ribosomal protein S11; Validated; Region: PRK05309 255470001282 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 255470001283 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 255470001284 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 255470001285 RNA binding surface [nucleotide binding]; other site 255470001286 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 255470001287 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 255470001288 alphaNTD - beta interaction site [polypeptide binding]; other site 255470001289 alphaNTD homodimer interface [polypeptide binding]; other site 255470001290 alphaNTD - beta' interaction site [polypeptide binding]; other site 255470001291 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 255470001292 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 255470001293 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 255470001294 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 255470001295 dimerization interface 3.5A [polypeptide binding]; other site 255470001296 active site 255470001297 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 255470001298 23S rRNA interface [nucleotide binding]; other site 255470001299 L3 interface [polypeptide binding]; other site 255470001300 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 255470001301 Domain of unknown function (DUF202); Region: DUF202; pfam02656 255470001302 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 255470001303 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_1; cd05017 255470001304 dimer interface [polypeptide binding]; other site 255470001305 active site 255470001306 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 255470001307 dimer interface [polypeptide binding]; other site 255470001308 active site 255470001309 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 255470001310 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 255470001311 active site 255470001312 substrate binding site [chemical binding]; other site 255470001313 metal binding site [ion binding]; metal-binding site 255470001314 S-adenosylmethionine synthetase; Validated; Region: PRK05250 255470001315 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 255470001316 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 255470001317 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 255470001318 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 255470001319 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 255470001320 homotetramer interface [polypeptide binding]; other site 255470001321 ligand binding site [chemical binding]; other site 255470001322 catalytic site [active] 255470001323 NAD binding site [chemical binding]; other site 255470001324 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 255470001325 Predicted kinase [General function prediction only]; Region: COG0645 255470001326 AAA domain; Region: AAA_33; pfam13671 255470001327 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 255470001328 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 255470001329 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 255470001330 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 255470001331 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 255470001332 ABC-2 type transporter; Region: ABC2_membrane; cl17235 255470001333 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 255470001334 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 255470001335 Walker A/P-loop; other site 255470001336 ATP binding site [chemical binding]; other site 255470001337 Q-loop/lid; other site 255470001338 ABC transporter signature motif; other site 255470001339 Walker B; other site 255470001340 D-loop; other site 255470001341 H-loop/switch region; other site 255470001342 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 255470001343 active site 2 [active] 255470001344 active site 1 [active] 255470001345 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 255470001346 active site 255470001347 catalytic site [active] 255470001348 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 255470001349 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 255470001350 HEAT repeats; Region: HEAT_2; pfam13646 255470001351 HEAT repeats; Region: HEAT_2; pfam13646 255470001352 HEAT repeats; Region: HEAT_2; pfam13646 255470001353 PAC2 family; Region: PAC2; pfam09754 255470001354 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 255470001355 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 255470001356 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 255470001357 This archaeal PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar...; Region: PGM_like1; cd03087 255470001358 active site 255470001359 substrate binding site [chemical binding]; other site 255470001360 metal binding site [ion binding]; metal-binding site 255470001361 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: Arch_glmU; TIGR03992 255470001362 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 255470001363 active site 255470001364 Substrate binding site; other site 255470001365 Mg++ binding site; other site 255470001366 Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636 255470001367 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: Arch_glmU; TIGR03992 255470001368 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 255470001369 active site 255470001370 Substrate binding site; other site 255470001371 Mg++ binding site; other site 255470001372 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 255470001373 putative trimer interface [polypeptide binding]; other site 255470001374 putative CoA binding site [chemical binding]; other site 255470001375 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 255470001376 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 255470001377 glutaminase active site [active] 255470001378 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 255470001379 dimer interface [polypeptide binding]; other site 255470001380 active site 255470001381 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 255470001382 dimer interface [polypeptide binding]; other site 255470001383 active site 255470001384 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 255470001385 substrate binding site [chemical binding]; other site 255470001386 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 255470001387 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 255470001388 motif II; other site 255470001389 diaminopimelate decarboxylase; Region: lysA; TIGR01048 255470001390 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 255470001391 active site 255470001392 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 255470001393 substrate binding site [chemical binding]; other site 255470001394 catalytic residues [active] 255470001395 dimer interface [polypeptide binding]; other site 255470001396 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 255470001397 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 255470001398 Walker A motif; other site 255470001399 ATP binding site [chemical binding]; other site 255470001400 Walker B motif; other site 255470001401 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 255470001402 arginine finger; other site 255470001403 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 255470001404 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 255470001405 active site 255470001406 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 255470001407 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 255470001408 Walker A motif; other site 255470001409 ATP binding site [chemical binding]; other site 255470001410 Walker B motif; other site 255470001411 arginine finger; other site 255470001412 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 255470001413 Walker A motif; other site 255470001414 ATP binding site [chemical binding]; other site 255470001415 Walker B motif; other site 255470001416 arginine finger; other site 255470001417 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 255470001418 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 255470001419 replicative DNA helicase; Region: DnaB; TIGR00665 255470001420 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 255470001421 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 255470001422 Walker A motif; other site 255470001423 ATP binding site [chemical binding]; other site 255470001424 Walker B motif; other site 255470001425 DNA binding loops [nucleotide binding] 255470001426 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 255470001427 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 255470001428 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 255470001429 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 255470001430 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 255470001431 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 255470001432 putative phosphate acyltransferase; Provisional; Region: PRK05331 255470001433 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 255470001434 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 255470001435 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 255470001436 metal binding site [ion binding]; metal-binding site 255470001437 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 255470001438 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 255470001439 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 255470001440 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 255470001441 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 255470001442 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 255470001443 non-specific DNA binding site [nucleotide binding]; other site 255470001444 salt bridge; other site 255470001445 sequence-specific DNA binding site [nucleotide binding]; other site 255470001446 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 255470001447 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 255470001448 Walker A/P-loop; other site 255470001449 ATP binding site [chemical binding]; other site 255470001450 Q-loop/lid; other site 255470001451 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 255470001452 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 255470001453 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 255470001454 ABC transporter signature motif; other site 255470001455 Walker B; other site 255470001456 D-loop; other site 255470001457 H-loop/switch region; other site 255470001458 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 255470001459 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 255470001460 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 255470001461 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 255470001462 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 255470001463 DNA binding residues [nucleotide binding] 255470001464 DNA primase; Validated; Region: dnaG; PRK05667 255470001465 CHC2 zinc finger; Region: zf-CHC2; cl17510 255470001466 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 255470001467 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 255470001468 active site 255470001469 metal binding site [ion binding]; metal-binding site 255470001470 interdomain interaction site; other site 255470001471 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 255470001472 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 255470001473 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 255470001474 Zn2+ binding site [ion binding]; other site 255470001475 Mg2+ binding site [ion binding]; other site 255470001476 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 255470001477 phosphoenolpyruvate synthase; Validated; Region: PRK06464 255470001478 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 255470001479 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 255470001480 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 255470001481 Bifunctional nuclease; Region: DNase-RNase; pfam02577 255470001482 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 255470001483 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 255470001484 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 255470001485 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 255470001486 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 255470001487 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 255470001488 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 255470001489 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 255470001490 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 255470001491 beta subunit interaction interface [polypeptide binding]; other site 255470001492 Walker A motif; other site 255470001493 ATP binding site [chemical binding]; other site 255470001494 Walker B motif; other site 255470001495 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 255470001496 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 255470001497 core domain interface [polypeptide binding]; other site 255470001498 delta subunit interface [polypeptide binding]; other site 255470001499 epsilon subunit interface [polypeptide binding]; other site 255470001500 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 255470001501 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 255470001502 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 255470001503 alpha subunit interaction interface [polypeptide binding]; other site 255470001504 Walker A motif; other site 255470001505 ATP binding site [chemical binding]; other site 255470001506 Walker B motif; other site 255470001507 inhibitor binding site; inhibition site 255470001508 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 255470001509 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 255470001510 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 255470001511 gamma subunit interface [polypeptide binding]; other site 255470001512 epsilon subunit interface [polypeptide binding]; other site 255470001513 LBP interface [polypeptide binding]; other site 255470001514 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 255470001515 RimM N-terminal domain; Region: RimM; pfam01782 255470001516 PRC-barrel domain; Region: PRC; pfam05239 255470001517 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 255470001518 KH domain; Region: KH_4; pfam13083 255470001519 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 255470001520 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 255470001521 Active_site [active] 255470001522 peptide chain release factor 2; Validated; Region: prfB; PRK00578 255470001523 PCRF domain; Region: PCRF; pfam03462 255470001524 RF-1 domain; Region: RF-1; pfam00472 255470001525 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 255470001526 Zn binding site [ion binding]; other site 255470001527 hypothetical protein; Reviewed; Region: PRK00024 255470001528 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 255470001529 helix-hairpin-helix signature motif; other site 255470001530 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 255470001531 MPN+ (JAMM) motif; other site 255470001532 substrate binding pocket [chemical binding]; other site 255470001533 Zinc-binding site [ion binding]; other site 255470001534 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 255470001535 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 255470001536 peptide binding site [polypeptide binding]; other site 255470001537 capreomycidine synthase; Region: viomycin_VioD; TIGR03947 255470001538 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 255470001539 pyridoxal 5'-phosphate binding site [chemical binding]; other site 255470001540 homodimer interface [polypeptide binding]; other site 255470001541 catalytic residue [active] 255470001542 seryl-tRNA synthetase; Provisional; Region: PRK05431 255470001543 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 255470001544 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 255470001545 dimer interface [polypeptide binding]; other site 255470001546 active site 255470001547 motif 1; other site 255470001548 motif 2; other site 255470001549 motif 3; other site 255470001550 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 255470001551 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 255470001552 dimer interface [polypeptide binding]; other site 255470001553 putative anticodon binding site; other site 255470001554 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 255470001555 motif 1; other site 255470001556 active site 255470001557 motif 2; other site 255470001558 motif 3; other site 255470001559 Recombination protein O N terminal; Region: RecO_N; pfam11967 255470001560 DNA repair protein RecO; Region: reco; TIGR00613 255470001561 Recombination protein O C terminal; Region: RecO_C; pfam02565 255470001562 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 255470001563 A new structural DNA glycosylase; Region: AlkD_like; cd06561 255470001564 active site 255470001565 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 255470001566 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 255470001567 oligomer interface [polypeptide binding]; other site 255470001568 metal binding site [ion binding]; metal-binding site 255470001569 metal binding site [ion binding]; metal-binding site 255470001570 Cl binding site [ion binding]; other site 255470001571 aspartate ring; other site 255470001572 basic sphincter; other site 255470001573 putative hydrophobic gate; other site 255470001574 periplasmic entrance; other site 255470001575 recombination protein RecR; Reviewed; Region: recR; PRK00076 255470001576 RecR protein; Region: RecR; pfam02132 255470001577 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 255470001578 putative active site [active] 255470001579 putative metal-binding site [ion binding]; other site 255470001580 tetramer interface [polypeptide binding]; other site 255470001581 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 255470001582 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 255470001583 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 255470001584 Walker A motif; other site 255470001585 ATP binding site [chemical binding]; other site 255470001586 Walker B motif; other site 255470001587 arginine finger; other site 255470001588 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 255470001589 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 255470001590 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 255470001591 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type2; cd02202 255470001592 Tubulin/FtsZ family, GTPase domain; Region: Tubulin; pfam00091 255470001593 nucleotide binding site [chemical binding]; other site 255470001594 SulA interaction site; other site 255470001595 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 255470001596 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 255470001597 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 255470001598 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 255470001599 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 255470001600 enolase; Provisional; Region: eno; PRK00077 255470001601 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 255470001602 dimer interface [polypeptide binding]; other site 255470001603 metal binding site [ion binding]; metal-binding site 255470001604 substrate binding pocket [chemical binding]; other site 255470001605 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 255470001606 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 255470001607 putative active site [active] 255470001608 catalytic residue [active] 255470001609 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 255470001610 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 255470001611 nucleotide binding pocket [chemical binding]; other site 255470001612 K-X-D-G motif; other site 255470001613 catalytic site [active] 255470001614 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 255470001615 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 255470001616 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 255470001617 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 255470001618 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 255470001619 Dimer interface [polypeptide binding]; other site 255470001620 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 255470001621 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 255470001622 predicted active site [active] 255470001623 catalytic triad [active] 255470001624 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 255470001625 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 255470001626 ligand binding site [chemical binding]; other site 255470001627 NAD binding site [chemical binding]; other site 255470001628 dimerization interface [polypeptide binding]; other site 255470001629 catalytic site [active] 255470001630 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 255470001631 putative L-serine binding site [chemical binding]; other site 255470001632 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 255470001633 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 255470001634 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 255470001635 catalytic residue [active] 255470001636 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 255470001637 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 255470001638 active site 255470001639 HIGH motif; other site 255470001640 dimer interface [polypeptide binding]; other site 255470001641 KMSKS motif; other site 255470001642 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 255470001643 RNA binding surface [nucleotide binding]; other site 255470001644 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 255470001645 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 255470001646 active site 255470001647 Riboflavin kinase; Region: Flavokinase; pfam01687 255470001648 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 255470001649 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 255470001650 RPB12 interaction site [polypeptide binding]; other site 255470001651 RPB1 interaction site [polypeptide binding]; other site 255470001652 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 255470001653 RPB10 interaction site [polypeptide binding]; other site 255470001654 RPB11 interaction site [polypeptide binding]; other site 255470001655 RPB3 interaction site [polypeptide binding]; other site 255470001656 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 255470001657 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 255470001658 beta and beta' interface [polypeptide binding]; other site 255470001659 beta' and sigma factor interface [polypeptide binding]; other site 255470001660 Zn-binding [ion binding]; other site 255470001661 active site region [active] 255470001662 catalytic site [active] 255470001663 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 255470001664 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 255470001665 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 255470001666 G-loop; other site 255470001667 DNA binding site [nucleotide binding] 255470001668 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 255470001669 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 255470001670 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 255470001671 Walker A motif; other site 255470001672 ATP binding site [chemical binding]; other site 255470001673 Walker B motif; other site 255470001674 arginine finger; other site 255470001675 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 255470001676 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 255470001677 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 255470001678 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 255470001679 Coenzyme A binding pocket [chemical binding]; other site 255470001680 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 255470001681 Predicted permease; Region: DUF318; cl17795 255470001682 Methyltransferase domain; Region: Methyltransf_23; pfam13489 255470001683 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 255470001684 S-adenosylmethionine binding site [chemical binding]; other site 255470001685 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 255470001686 FeS/SAM binding site; other site 255470001687 Radical SAM superfamily; Region: Radical_SAM; pfam04055 255470001688 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 255470001689 Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941 255470001690 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 255470001691 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 255470001692 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 255470001693 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 255470001694 Endopeptidases belonging to F420-reducing hydrogenases group. These hydrogenases from methanogens are encoded by the fru, frc, or frh genes. Sequence comparison indicates that fruD and frcD gene products from Methanococcus voltae are similar to HycI...; Region: H2MP_F420-Reduc; cd06064 255470001695 nickel binding site [ion binding]; other site 255470001696 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 255470001697 catalytic residues [active] 255470001698 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 255470001699 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 255470001700 Putative small multi-drug export protein; Region: Sm_multidrug_ex; cl01024 255470001701 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 255470001702 FeS/SAM binding site; other site 255470001703 Radical SAM superfamily; Region: Radical_SAM; pfam04055 255470001704 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 255470001705 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 255470001706 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 255470001707 active site 255470001708 effector binding site; other site 255470001709 dimer interface [polypeptide binding]; other site 255470001710 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 255470001711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 255470001712 active site 255470001713 phosphorylation site [posttranslational modification] 255470001714 intermolecular recognition site; other site 255470001715 dimerization interface [polypeptide binding]; other site 255470001716 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 255470001717 Zn2+ binding site [ion binding]; other site 255470001718 Mg2+ binding site [ion binding]; other site 255470001719 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 255470001720 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470001721 putative active site [active] 255470001722 heme pocket [chemical binding]; other site 255470001723 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470001724 putative active site [active] 255470001725 heme pocket [chemical binding]; other site 255470001726 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 255470001727 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 255470001728 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470001729 putative active site [active] 255470001730 heme pocket [chemical binding]; other site 255470001731 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 255470001732 dimer interface [polypeptide binding]; other site 255470001733 phosphorylation site [posttranslational modification] 255470001734 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 255470001735 ATP binding site [chemical binding]; other site 255470001736 Mg2+ binding site [ion binding]; other site 255470001737 G-X-G motif; other site 255470001738 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 255470001739 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 255470001740 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 255470001741 FeS/SAM binding site; other site 255470001742 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 255470001743 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 255470001744 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 255470001745 ATP-grasp domain; Region: ATP-grasp_4; cl17255 255470001746 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 255470001747 metal binding site 2 [ion binding]; metal-binding site 255470001748 putative DNA binding helix; other site 255470001749 metal binding site 1 [ion binding]; metal-binding site 255470001750 dimer interface [polypeptide binding]; other site 255470001751 structural Zn2+ binding site [ion binding]; other site 255470001752 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 255470001753 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 255470001754 intersubunit interface [polypeptide binding]; other site 255470001755 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 255470001756 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 255470001757 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 255470001758 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 255470001759 ABC-ATPase subunit interface; other site 255470001760 dimer interface [polypeptide binding]; other site 255470001761 putative PBP binding regions; other site 255470001762 cell division protein FtsZ; Validated; Region: PRK09330 255470001763 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 255470001764 nucleotide binding site [chemical binding]; other site 255470001765 SulA interaction site; other site 255470001766 cell division protein FtsA; Region: ftsA; TIGR01174 255470001767 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 255470001768 nucleotide binding site [chemical binding]; other site 255470001769 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 255470001770 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 255470001771 Cell division protein FtsA; Region: FtsA; pfam14450 255470001772 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 255470001773 Ligand Binding Site [chemical binding]; other site 255470001774 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 255470001775 Ligand Binding Site [chemical binding]; other site 255470001776 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 255470001777 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 255470001778 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 255470001779 substrate binding site [chemical binding]; other site 255470001780 hexamer interface [polypeptide binding]; other site 255470001781 metal binding site [ion binding]; metal-binding site 255470001782 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 255470001783 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 255470001784 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 255470001785 TPP-binding site [chemical binding]; other site 255470001786 dimer interface [polypeptide binding]; other site 255470001787 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 255470001788 PYR/PP interface [polypeptide binding]; other site 255470001789 dimer interface [polypeptide binding]; other site 255470001790 TPP binding site [chemical binding]; other site 255470001791 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 255470001792 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 255470001793 putative FMN binding site [chemical binding]; other site 255470001794 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 255470001795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 255470001796 S-adenosylmethionine binding site [chemical binding]; other site 255470001797 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 255470001798 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 255470001799 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 255470001800 cobalamin binding residues [chemical binding]; other site 255470001801 putative BtuC binding residues; other site 255470001802 dimer interface [polypeptide binding]; other site 255470001803 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 255470001804 ABC-ATPase subunit interface; other site 255470001805 dimer interface [polypeptide binding]; other site 255470001806 putative PBP binding regions; other site 255470001807 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 255470001808 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 255470001809 Walker A/P-loop; other site 255470001810 ATP binding site [chemical binding]; other site 255470001811 Q-loop/lid; other site 255470001812 ABC transporter signature motif; other site 255470001813 Walker B; other site 255470001814 D-loop; other site 255470001815 H-loop/switch region; other site 255470001816 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 255470001817 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 255470001818 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 255470001819 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 255470001820 pyridoxal 5'-phosphate binding site [chemical binding]; other site 255470001821 homodimer interface [polypeptide binding]; other site 255470001822 catalytic residue [active] 255470001823 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 255470001824 putative dimer interface [polypeptide binding]; other site 255470001825 active site pocket [active] 255470001826 putative cataytic base [active] 255470001827 cobalamin synthase; Reviewed; Region: cobS; PRK00235 255470001828 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 255470001829 catalytic core [active] 255470001830 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; pfam02283 255470001831 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 255470001832 catalytic residues [active] 255470001833 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 255470001834 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 255470001835 Histidine kinase; Region: HisKA_3; pfam07730 255470001836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 255470001837 ATP binding site [chemical binding]; other site 255470001838 Mg2+ binding site [ion binding]; other site 255470001839 G-X-G motif; other site 255470001840 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 255470001841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 255470001842 active site 255470001843 phosphorylation site [posttranslational modification] 255470001844 intermolecular recognition site; other site 255470001845 dimerization interface [polypeptide binding]; other site 255470001846 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 255470001847 DNA binding residues [nucleotide binding] 255470001848 dimerization interface [polypeptide binding]; other site 255470001849 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 255470001850 acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional; Region: PRK04165 255470001851 Putative Fe-S cluster; Region: FeS; pfam04060 255470001852 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 255470001853 bifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta; Reviewed; Region: PRK09529 255470001854 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 255470001855 ACS interaction site; other site 255470001856 CODH interaction site; other site 255470001857 metal cluster binding site [ion binding]; other site 255470001858 CO dehydrogenase/acetyl-CoA synthase complex beta subunit; Region: CdhC; pfam03598 255470001859 acetyl-CoA decarbonylase/synthase complex subunit delta; Provisional; Region: PRK04452 255470001860 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 255470001861 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 255470001862 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 255470001863 homodimer interface [polypeptide binding]; other site 255470001864 NADP binding site [chemical binding]; other site 255470001865 substrate binding site [chemical binding]; other site 255470001866 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 255470001867 P-loop; other site 255470001868 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 255470001869 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 255470001870 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 255470001871 catalytic loop [active] 255470001872 iron binding site [ion binding]; other site 255470001873 Domain of unknown function (DUF4445); Region: DUF4445; pfam14574 255470001874 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 255470001875 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 255470001876 Potassium binding sites [ion binding]; other site 255470001877 Cesium cation binding sites [ion binding]; other site 255470001878 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 255470001879 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 255470001880 dimer interface [polypeptide binding]; other site 255470001881 anticodon binding site; other site 255470001882 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 255470001883 motif 1; other site 255470001884 dimer interface [polypeptide binding]; other site 255470001885 active site 255470001886 motif 2; other site 255470001887 GAD domain; Region: GAD; pfam02938 255470001888 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 255470001889 active site 255470001890 motif 3; other site 255470001891 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 255470001892 trigger factor; Region: tig; TIGR00115 255470001893 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 255470001894 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 255470001895 oligomer interface [polypeptide binding]; other site 255470001896 active site residues [active] 255470001897 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 255470001898 substrate binding site [chemical binding]; other site 255470001899 ATP binding site [chemical binding]; other site 255470001900 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 255470001901 substrate binding site [chemical binding]; other site 255470001902 active site 255470001903 cosubstrate binding site; other site 255470001904 catalytic site [active] 255470001905 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 255470001906 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 255470001907 active site 255470001908 PHP-associated; Region: PHP_C; pfam13263 255470001909 translation elongation factor P; Region: efp; TIGR00038 255470001910 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 255470001911 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 255470001912 RNA binding site [nucleotide binding]; other site 255470001913 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 255470001914 RNA binding site [nucleotide binding]; other site 255470001915 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 255470001916 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 255470001917 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 255470001918 active site 255470001919 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 255470001920 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 255470001921 active site 255470001922 Int/Topo IB signature motif; other site 255470001923 DNA topoisomerase I; Validated; Region: PRK05582 255470001924 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 255470001925 active site 255470001926 interdomain interaction site; other site 255470001927 putative metal-binding site [ion binding]; other site 255470001928 nucleotide binding site [chemical binding]; other site 255470001929 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 255470001930 domain I; other site 255470001931 DNA binding groove [nucleotide binding] 255470001932 phosphate binding site [ion binding]; other site 255470001933 domain II; other site 255470001934 domain III; other site 255470001935 nucleotide binding site [chemical binding]; other site 255470001936 catalytic site [active] 255470001937 domain IV; other site 255470001938 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 255470001939 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 255470001940 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 255470001941 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 255470001942 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 255470001943 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 255470001944 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; Region: PorC_KorC; TIGR02175 255470001945 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 255470001946 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179 255470001947 pyruvate ferredoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK08367 255470001948 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 255470001949 dimer interface [polypeptide binding]; other site 255470001950 PYR/PP interface [polypeptide binding]; other site 255470001951 TPP binding site [chemical binding]; other site 255470001952 substrate binding site [chemical binding]; other site 255470001953 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 255470001954 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 255470001955 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 255470001956 TPP-binding site [chemical binding]; other site 255470001957 putative dimer interface [polypeptide binding]; other site 255470001958 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 255470001959 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 255470001960 putative dimer interface [polypeptide binding]; other site 255470001961 [2Fe-2S] cluster binding site [ion binding]; other site 255470001962 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 255470001963 dimer interface [polypeptide binding]; other site 255470001964 [2Fe-2S] cluster binding site [ion binding]; other site 255470001965 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 255470001966 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 255470001967 SLBB domain; Region: SLBB; pfam10531 255470001968 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 255470001969 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 255470001970 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 255470001971 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 255470001972 catalytic loop [active] 255470001973 iron binding site [ion binding]; other site 255470001974 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 255470001975 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 255470001976 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 255470001977 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 255470001978 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 255470001979 Moco binding site; other site 255470001980 metal coordination site [ion binding]; other site 255470001981 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 255470001982 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 255470001983 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 255470001984 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 255470001985 Zinc ribbon domain; Region: Zn-ribbon_8; pfam09723 255470001986 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 255470001987 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 255470001988 NAD(P) binding site [chemical binding]; other site 255470001989 active site 255470001990 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 255470001991 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 255470001992 HflX GTPase family; Region: HflX; cd01878 255470001993 G1 box; other site 255470001994 GTP/Mg2+ binding site [chemical binding]; other site 255470001995 Switch I region; other site 255470001996 G2 box; other site 255470001997 G3 box; other site 255470001998 Switch II region; other site 255470001999 G4 box; other site 255470002000 G5 box; other site 255470002001 HicB family; Region: HicB; pfam05534 255470002002 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 255470002003 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 255470002004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 255470002005 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 255470002006 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 255470002007 catalytic residues [active] 255470002008 catalytic nucleophile [active] 255470002009 Presynaptic Site I dimer interface [polypeptide binding]; other site 255470002010 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 255470002011 Synaptic Flat tetramer interface [polypeptide binding]; other site 255470002012 Synaptic Site I dimer interface [polypeptide binding]; other site 255470002013 DNA binding site [nucleotide binding] 255470002014 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 255470002015 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 255470002016 pyridoxal 5'-phosphate binding site [chemical binding]; other site 255470002017 homodimer interface [polypeptide binding]; other site 255470002018 catalytic residue [active] 255470002019 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 255470002020 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 255470002021 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 255470002022 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 255470002023 triosephosphate isomerase; Provisional; Region: PRK14565 255470002024 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 255470002025 substrate binding site [chemical binding]; other site 255470002026 dimer interface [polypeptide binding]; other site 255470002027 catalytic triad [active] 255470002028 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04135 255470002029 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 255470002030 substrate binding site [chemical binding]; other site 255470002031 hinge regions; other site 255470002032 ADP binding site [chemical binding]; other site 255470002033 catalytic site [active] 255470002034 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 255470002035 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 255470002036 TPP-binding site; other site 255470002037 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 255470002038 PYR/PP interface [polypeptide binding]; other site 255470002039 dimer interface [polypeptide binding]; other site 255470002040 TPP binding site [chemical binding]; other site 255470002041 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 255470002042 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 255470002043 GAF domain; Region: GAF_2; pfam13185 255470002044 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 255470002045 active site 255470002046 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 255470002047 23S rRNA binding site [nucleotide binding]; other site 255470002048 L21 binding site [polypeptide binding]; other site 255470002049 L13 binding site [polypeptide binding]; other site 255470002050 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 255470002051 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 255470002052 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 255470002053 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 255470002054 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 255470002055 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 255470002056 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 255470002057 active site 255470002058 dimer interface [polypeptide binding]; other site 255470002059 motif 1; other site 255470002060 motif 2; other site 255470002061 motif 3; other site 255470002062 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 255470002063 anticodon binding site; other site 255470002064 MAEBL; Provisional; Region: PTZ00121 255470002065 MAEBL; Provisional; Region: PTZ00121 255470002066 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 255470002067 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 255470002068 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 255470002069 catalytic residue [active] 255470002070 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 255470002071 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 255470002072 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 255470002073 active site 255470002074 catalytic residues [active] 255470002075 metal binding site [ion binding]; metal-binding site 255470002076 Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945 255470002077 Putative lysophospholipase; Region: Hydrolase_4; cl19140 255470002078 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 255470002079 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 255470002080 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 255470002081 Predicted membrane protein [Function unknown]; Region: COG4818 255470002082 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 255470002083 Peptidase family M50; Region: Peptidase_M50; pfam02163 255470002084 active site 255470002085 putative substrate binding region [chemical binding]; other site 255470002086 FOG: CBS domain [General function prediction only]; Region: COG0517 255470002087 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 255470002088 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 255470002089 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 255470002090 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 255470002091 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 255470002092 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 255470002093 CAAX protease self-immunity; Region: Abi; pfam02517 255470002094 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 255470002095 Peptidase family M50; Region: Peptidase_M50; pfam02163 255470002096 active site 255470002097 putative substrate binding region [chemical binding]; other site 255470002098 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 255470002099 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 255470002100 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 255470002101 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 255470002102 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 255470002103 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 255470002104 Walker A motif; other site 255470002105 ATP binding site [chemical binding]; other site 255470002106 Walker B motif; other site 255470002107 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 255470002108 RxxxH motif; other site 255470002109 thymidylate kinase; Validated; Region: tmk; PRK00698 255470002110 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 255470002111 TMP-binding site; other site 255470002112 ATP-binding site [chemical binding]; other site 255470002113 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 255470002114 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 255470002115 Ligand Binding Site [chemical binding]; other site 255470002116 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 255470002117 RNA/DNA hybrid binding site [nucleotide binding]; other site 255470002118 active site 255470002119 hypothetical protein; Provisional; Region: PRK14688 255470002120 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 255470002121 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 255470002122 thiamine phosphate binding site [chemical binding]; other site 255470002123 active site 255470002124 pyrophosphate binding site [ion binding]; other site 255470002125 haloacid dehalogenase superfamily protein; Provisional; Region: PRK14562 255470002126 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 255470002127 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 255470002128 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 255470002129 glycyl-tRNA synthetase; Provisional; Region: PRK04173 255470002130 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 255470002131 dimer interface [polypeptide binding]; other site 255470002132 motif 1; other site 255470002133 active site 255470002134 motif 2; other site 255470002135 motif 3; other site 255470002136 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 255470002137 anticodon binding site; other site 255470002138 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 255470002139 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 255470002140 active site 255470002141 metal binding site [ion binding]; metal-binding site 255470002142 DNA binding site [nucleotide binding] 255470002143 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 255470002144 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 255470002145 RNA binding surface [nucleotide binding]; other site 255470002146 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 255470002147 active site 255470002148 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 255470002149 active site 255470002150 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 255470002151 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 255470002152 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 255470002153 active site 255470002154 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 255470002155 active site 255470002156 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 255470002157 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 255470002158 Walker A/P-loop; other site 255470002159 ATP binding site [chemical binding]; other site 255470002160 Q-loop/lid; other site 255470002161 ABC transporter signature motif; other site 255470002162 Walker B; other site 255470002163 D-loop; other site 255470002164 H-loop/switch region; other site 255470002165 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 255470002166 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 255470002167 ABC-2 type transporter; Region: ABC2_membrane; cl17235 255470002168 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 255470002169 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 255470002170 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 255470002171 Uncharacterized conserved protein [Function unknown]; Region: COG5495 255470002172 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 255470002173 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 255470002174 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 255470002175 tetramerization interface [polypeptide binding]; other site 255470002176 active site 255470002177 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 255470002178 oligomerization interface [polypeptide binding]; other site 255470002179 active site 255470002180 metal binding site [ion binding]; metal-binding site 255470002181 Pantoate-beta-alanine ligase; Region: PanC; cd00560 255470002182 active site 255470002183 ATP-binding site [chemical binding]; other site 255470002184 pantoate-binding site; other site 255470002185 HXXH motif; other site 255470002186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 255470002187 Major Facilitator Superfamily; Region: MFS_1; pfam07690 255470002188 putative substrate translocation pore; other site 255470002189 Transcriptional regulators [Transcription]; Region: MarR; COG1846 255470002190 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 255470002191 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 255470002192 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 255470002193 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 255470002194 Predicted membrane protein (DUF2070); Region: DUF2070; cl19221 255470002195 PAP2 superfamily; Region: PAP2; pfam01569 255470002196 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 255470002197 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 255470002198 Walker A/P-loop; other site 255470002199 ATP binding site [chemical binding]; other site 255470002200 Q-loop/lid; other site 255470002201 ABC transporter signature motif; other site 255470002202 Walker B; other site 255470002203 D-loop; other site 255470002204 H-loop/switch region; other site 255470002205 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 255470002206 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 255470002207 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 255470002208 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 255470002209 Walker A/P-loop; other site 255470002210 ATP binding site [chemical binding]; other site 255470002211 Q-loop/lid; other site 255470002212 ABC transporter signature motif; other site 255470002213 Walker B; other site 255470002214 D-loop; other site 255470002215 H-loop/switch region; other site 255470002216 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 255470002217 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 255470002218 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 255470002219 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 255470002220 Walker A/P-loop; other site 255470002221 ATP binding site [chemical binding]; other site 255470002222 Q-loop/lid; other site 255470002223 ABC transporter signature motif; other site 255470002224 Walker B; other site 255470002225 D-loop; other site 255470002226 H-loop/switch region; other site 255470002227 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 255470002228 dimerization interface [polypeptide binding]; other site 255470002229 active site 255470002230 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 255470002231 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 255470002232 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 255470002233 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 255470002234 putative FMN binding site [chemical binding]; other site 255470002235 NADPH bind site [chemical binding]; other site 255470002236 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 255470002237 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 255470002238 active site 255470002239 catalytic residues [active] 255470002240 metal binding site [ion binding]; metal-binding site 255470002241 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 255470002242 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 255470002243 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 255470002244 substrate binding site [chemical binding]; other site 255470002245 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 255470002246 substrate binding site [chemical binding]; other site 255470002247 ligand binding site [chemical binding]; other site 255470002248 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 255470002249 MgtC family; Region: MgtC; pfam02308 255470002250 2-isopropylmalate synthase; Validated; Region: PRK00915 255470002251 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 255470002252 active site 255470002253 catalytic residues [active] 255470002254 metal binding site [ion binding]; metal-binding site 255470002255 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 255470002256 ketol-acid reductoisomerase; Provisional; Region: PRK05479 255470002257 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 255470002258 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 255470002259 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 255470002260 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 255470002261 putative valine binding site [chemical binding]; other site 255470002262 dimer interface [polypeptide binding]; other site 255470002263 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 255470002264 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 255470002265 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 255470002266 PYR/PP interface [polypeptide binding]; other site 255470002267 dimer interface [polypeptide binding]; other site 255470002268 TPP binding site [chemical binding]; other site 255470002269 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 255470002270 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 255470002271 TPP-binding site [chemical binding]; other site 255470002272 dimer interface [polypeptide binding]; other site 255470002273 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 255470002274 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 255470002275 GMP synthase; Reviewed; Region: guaA; PRK00074 255470002276 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 255470002277 AMP/PPi binding site [chemical binding]; other site 255470002278 candidate oxyanion hole; other site 255470002279 catalytic triad [active] 255470002280 potential glutamine specificity residues [chemical binding]; other site 255470002281 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 255470002282 ATP Binding subdomain [chemical binding]; other site 255470002283 Ligand Binding sites [chemical binding]; other site 255470002284 Dimerization subdomain; other site 255470002285 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 255470002286 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 255470002287 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 255470002288 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 255470002289 AIR carboxylase; Region: AIRC; pfam00731 255470002290 adenylosuccinate lyase; Provisional; Region: PRK07492 255470002291 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 255470002292 tetramer interface [polypeptide binding]; other site 255470002293 active site 255470002294 phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional; Region: PRK13959 255470002295 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 255470002296 active site 255470002297 ATP binding site [chemical binding]; other site 255470002298 substrate binding site [chemical binding]; other site 255470002299 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 255470002300 putative active site pocket [active] 255470002301 4-fold oligomerization interface [polypeptide binding]; other site 255470002302 metal binding residues [ion binding]; metal-binding site 255470002303 3-fold/trimer interface [polypeptide binding]; other site 255470002304 histidinol-phosphate aminotransferase; Provisional; Region: PLN03026 255470002305 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 255470002306 pyridoxal 5'-phosphate binding site [chemical binding]; other site 255470002307 homodimer interface [polypeptide binding]; other site 255470002308 catalytic residue [active] 255470002309 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 255470002310 histidinol dehydrogenase; Region: hisD; TIGR00069 255470002311 NAD binding site [chemical binding]; other site 255470002312 dimerization interface [polypeptide binding]; other site 255470002313 product binding site; other site 255470002314 substrate binding site [chemical binding]; other site 255470002315 zinc binding site [ion binding]; other site 255470002316 catalytic residues [active] 255470002317 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 255470002318 ATP phosphoribosyltransferase; Region: HisG; cl15266 255470002319 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 255470002320 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 255470002321 dimer interface [polypeptide binding]; other site 255470002322 motif 1; other site 255470002323 active site 255470002324 motif 2; other site 255470002325 motif 3; other site 255470002326 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 255470002327 prohibitin homologues; Region: PHB; smart00244 255470002328 Uncharacterized prokaryotic subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_eoslipins_u1; cd08826 255470002329 trimer interface [polypeptide binding]; other site 255470002330 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 255470002331 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 255470002332 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 255470002333 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 255470002334 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 255470002335 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 255470002336 Walker A/P-loop; other site 255470002337 ATP binding site [chemical binding]; other site 255470002338 Q-loop/lid; other site 255470002339 ABC transporter signature motif; other site 255470002340 Walker B; other site 255470002341 D-loop; other site 255470002342 H-loop/switch region; other site 255470002343 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 255470002344 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 255470002345 Acyltransferase family; Region: Acyl_transf_3; cl19154 255470002346 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 255470002347 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 255470002348 FtsX-like permease family; Region: FtsX; pfam02687 255470002349 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 255470002350 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 255470002351 Walker A/P-loop; other site 255470002352 ATP binding site [chemical binding]; other site 255470002353 Q-loop/lid; other site 255470002354 ABC transporter signature motif; other site 255470002355 Walker B; other site 255470002356 D-loop; other site 255470002357 H-loop/switch region; other site 255470002358 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 255470002359 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 255470002360 FeS/SAM binding site; other site 255470002361 HemN C-terminal domain; Region: HemN_C; pfam06969 255470002362 GTP-binding protein LepA; Provisional; Region: PRK05433 255470002363 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 255470002364 G1 box; other site 255470002365 putative GEF interaction site [polypeptide binding]; other site 255470002366 GTP/Mg2+ binding site [chemical binding]; other site 255470002367 Switch I region; other site 255470002368 G2 box; other site 255470002369 G3 box; other site 255470002370 Switch II region; other site 255470002371 G4 box; other site 255470002372 G5 box; other site 255470002373 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 255470002374 Elongation Factor G, domain II; Region: EFG_II; pfam14492 255470002375 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 255470002376 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 255470002377 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651 255470002378 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 255470002379 NADH dehydrogenase; Region: NADHdh; cl00469 255470002380 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 255470002381 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 255470002382 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 255470002383 putative dimer interface [polypeptide binding]; other site 255470002384 [2Fe-2S] cluster binding site [ion binding]; other site 255470002385 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 255470002386 dimer interface [polypeptide binding]; other site 255470002387 [2Fe-2S] cluster binding site [ion binding]; other site 255470002388 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 255470002389 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 255470002390 SLBB domain; Region: SLBB; pfam10531 255470002391 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 255470002392 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 255470002393 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 255470002394 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 255470002395 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 255470002396 catalytic loop [active] 255470002397 iron binding site [ion binding]; other site 255470002398 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 255470002399 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 255470002400 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl19197 255470002401 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 255470002402 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 255470002403 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 255470002404 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 255470002405 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 255470002406 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 255470002407 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 255470002408 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 255470002409 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 255470002410 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 255470002411 motif 1; other site 255470002412 dimer interface [polypeptide binding]; other site 255470002413 active site 255470002414 motif 2; other site 255470002415 motif 3; other site 255470002416 elongation factor P; Validated; Region: PRK00529 255470002417 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 255470002418 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 255470002419 RNA binding site [nucleotide binding]; other site 255470002420 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 255470002421 RNA binding site [nucleotide binding]; other site 255470002422 Transcriptional regulators [Transcription]; Region: MarR; COG1846 255470002423 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 255470002424 Transport protein; Region: actII; TIGR00833 255470002425 MMPL family; Region: MMPL; cl14618 255470002426 MMPL family; Region: MMPL; cl14618 255470002427 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 255470002428 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 255470002429 non-specific DNA binding site [nucleotide binding]; other site 255470002430 salt bridge; other site 255470002431 sequence-specific DNA binding site [nucleotide binding]; other site 255470002432 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 255470002433 Catalytic site [active] 255470002434 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 255470002435 putative Zn2+ binding site [ion binding]; other site 255470002436 putative DNA binding site [nucleotide binding]; other site 255470002437 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 255470002438 Citrate transporter; Region: CitMHS; pfam03600 255470002439 transmembrane helices; other site 255470002440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 255470002441 putative substrate translocation pore; other site 255470002442 Major Facilitator Superfamily; Region: MFS_1; pfam07690 255470002443 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 255470002444 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 255470002445 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 255470002446 active site 255470002447 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 255470002448 dinuclear metal binding motif [ion binding]; other site 255470002449 PAC2 family; Region: PAC2; pfam09754 255470002450 PAC2 family; Region: PAC2; pfam09754 255470002451 ATP-dependent DNA ligase; Provisional; Region: PRK01109 255470002452 hypothetical protein; Provisional; Region: PRK04334 255470002453 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 255470002454 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 255470002455 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 255470002456 Domain of unknown function DUF39; Region: DUF39; pfam01837 255470002457 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 255470002458 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 255470002459 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 255470002460 Walker A motif; other site 255470002461 Walker A/P-loop; other site 255470002462 ATP binding site [chemical binding]; other site 255470002463 ATP binding site [chemical binding]; other site 255470002464 Walker B motif; other site 255470002465 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 255470002466 NADH dehydrogenase subunit B; Validated; Region: PRK06411 255470002467 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl19197 255470002468 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 255470002469 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 255470002470 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 255470002471 Ferredoxin [Energy production and conversion]; Region: COG1146 255470002472 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 255470002473 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 255470002474 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 255470002475 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 255470002476 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 255470002477 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 255470002478 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 255470002479 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 255470002480 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 255470002481 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 255470002482 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 255470002483 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 255470002484 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 255470002485 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 255470002486 active site 255470002487 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 255470002488 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 255470002489 minor groove reading motif; other site 255470002490 helix-hairpin-helix signature motif; other site 255470002491 substrate binding pocket [chemical binding]; other site 255470002492 active site 255470002493 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 255470002494 cobyric acid synthase; Provisional; Region: PRK00784 255470002495 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 255470002496 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 255470002497 catalytic triad [active] 255470002498 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 255470002499 CoenzymeA binding site [chemical binding]; other site 255470002500 subunit interaction site [polypeptide binding]; other site 255470002501 PHB binding site; other site 255470002502 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 255470002503 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 255470002504 Walker A/P-loop; other site 255470002505 ATP binding site [chemical binding]; other site 255470002506 Q-loop/lid; other site 255470002507 ABC transporter signature motif; other site 255470002508 Walker B; other site 255470002509 D-loop; other site 255470002510 H-loop/switch region; other site 255470002511 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 255470002512 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 255470002513 acyl-activating enzyme (AAE) consensus motif; other site 255470002514 active site 255470002515 AMP binding site [chemical binding]; other site 255470002516 CoA binding site [chemical binding]; other site 255470002517 AMP-binding enzyme C-terminal domain; Region: AMP-binding_C; cl17063 255470002518 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 255470002519 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 255470002520 Walker A/P-loop; other site 255470002521 ATP binding site [chemical binding]; other site 255470002522 Q-loop/lid; other site 255470002523 ABC transporter signature motif; other site 255470002524 Walker B; other site 255470002525 D-loop; other site 255470002526 H-loop/switch region; other site 255470002527 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 255470002528 ligand binding site [chemical binding]; other site 255470002529 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 255470002530 ligand binding site [chemical binding]; other site 255470002531 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 255470002532 TM-ABC transporter signature motif; other site 255470002533 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 255470002534 TM-ABC transporter signature motif; other site 255470002535 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 255470002536 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 255470002537 putative AMP binding site [chemical binding]; other site 255470002538 putative active site [active] 255470002539 putative CoA binding site [chemical binding]; other site 255470002540 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 255470002541 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 255470002542 dimer interface [polypeptide binding]; other site 255470002543 PYR/PP interface [polypeptide binding]; other site 255470002544 TPP binding site [chemical binding]; other site 255470002545 substrate binding site [chemical binding]; other site 255470002546 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 255470002547 TPP-binding site; other site 255470002548 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 255470002549 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 255470002550 DNA polymerase II large subunit; Validated; Region: PRK04023 255470002551 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 255470002552 trimerization site [polypeptide binding]; other site 255470002553 active site 255470002554 Predicted membrane protein [Function unknown]; Region: COG3462 255470002555 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 255470002556 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 255470002557 metal-binding site [ion binding] 255470002558 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 255470002559 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 255470002560 metal-binding site [ion binding] 255470002561 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 255470002562 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 255470002563 motif II; other site 255470002564 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 255470002565 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 255470002566 putative dimer interface [polypeptide binding]; other site 255470002567 Ferritin-like domain; Region: Ferritin; pfam00210 255470002568 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 255470002569 dinuclear metal binding motif [ion binding]; other site 255470002570 Ferritin-like domain; Region: Ferritin; pfam00210 255470002571 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 255470002572 dinuclear metal binding motif [ion binding]; other site 255470002573 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 255470002574 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 255470002575 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 255470002576 Smr domain; Region: Smr; pfam01713 255470002577 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 255470002578 substrate binding site [chemical binding]; other site 255470002579 glutamase interaction surface [polypeptide binding]; other site 255470002580 Repressor of nif and glnA expression [Transcription]; Region: COG1693 255470002581 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 255470002582 Domain of unknown function DUF128; Region: DUF128; pfam01995 255470002583 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 255470002584 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 255470002585 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 255470002586 FeS/SAM binding site; other site 255470002587 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 255470002588 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 255470002589 dimer interface [polypeptide binding]; other site 255470002590 active site 255470002591 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 255470002592 DHH family; Region: DHH; pfam01368 255470002593 DHHA1 domain; Region: DHHA1; pfam02272 255470002594 membrane protein; Provisional; Region: PRK14414 255470002595 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 255470002596 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 255470002597 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 255470002598 ATP binding site [chemical binding]; other site 255470002599 putative Mg++ binding site [ion binding]; other site 255470002600 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 255470002601 nucleotide binding region [chemical binding]; other site 255470002602 ATP-binding site [chemical binding]; other site 255470002603 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 255470002604 Protein of unknown function (DUF503); Region: DUF503; pfam04456 255470002605 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 255470002606 16S/18S rRNA binding site [nucleotide binding]; other site 255470002607 S13e-L30e interaction site [polypeptide binding]; other site 255470002608 25S rRNA binding site [nucleotide binding]; other site 255470002609 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 255470002610 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 255470002611 RNase E interface [polypeptide binding]; other site 255470002612 trimer interface [polypeptide binding]; other site 255470002613 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 255470002614 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 255470002615 RNase E interface [polypeptide binding]; other site 255470002616 trimer interface [polypeptide binding]; other site 255470002617 active site 255470002618 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 255470002619 putative nucleic acid binding region [nucleotide binding]; other site 255470002620 G-X-X-G motif; other site 255470002621 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 255470002622 RNA binding site [nucleotide binding]; other site 255470002623 domain interface; other site 255470002624 dihydrodipicolinate reductase; Provisional; Region: PRK00048 255470002625 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 255470002626 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 255470002627 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 255470002628 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 255470002629 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 255470002630 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 255470002631 dihydrodipicolinate synthase; Region: dapA; TIGR00674 255470002632 dimer interface [polypeptide binding]; other site 255470002633 active site 255470002634 catalytic residue [active] 255470002635 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 255470002636 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 255470002637 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 255470002638 Coenzyme A binding pocket [chemical binding]; other site 255470002639 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 255470002640 GDP-binding site [chemical binding]; other site 255470002641 ACT binding site; other site 255470002642 IMP binding site; other site 255470002643 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 255470002644 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 255470002645 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 255470002646 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 255470002647 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 255470002648 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 255470002649 RNA binding site [nucleotide binding]; other site 255470002650 active site 255470002651 Ribosome-binding factor A; Region: RBFA; pfam02033 255470002652 translation initiation factor IF-2; Region: IF-2; TIGR00487 255470002653 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 255470002654 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 255470002655 G1 box; other site 255470002656 putative GEF interaction site [polypeptide binding]; other site 255470002657 GTP/Mg2+ binding site [chemical binding]; other site 255470002658 Switch I region; other site 255470002659 G2 box; other site 255470002660 G3 box; other site 255470002661 Switch II region; other site 255470002662 G4 box; other site 255470002663 G5 box; other site 255470002664 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 255470002665 Translation-initiation factor 2; Region: IF-2; pfam11987 255470002666 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 255470002667 Protein of unknown function (DUF448); Region: DUF448; pfam04296 255470002668 putative RNA binding cleft [nucleotide binding]; other site 255470002669 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 255470002670 NusA N-terminal domain; Region: NusA_N; pfam08529 255470002671 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 255470002672 RNA binding site [nucleotide binding]; other site 255470002673 homodimer interface [polypeptide binding]; other site 255470002674 NusA-like KH domain; Region: KH_5; pfam13184 255470002675 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 255470002676 G-X-X-G motif; other site 255470002677 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 255470002678 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 255470002679 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 255470002680 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 255470002681 Walker A motif; other site 255470002682 ATP binding site [chemical binding]; other site 255470002683 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 255470002684 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 255470002685 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 255470002686 Coenzyme A binding pocket [chemical binding]; other site 255470002687 Protein of unknown function (DUF502); Region: DUF502; cl01107 255470002688 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 255470002689 core dimer interface [polypeptide binding]; other site 255470002690 peripheral dimer interface [polypeptide binding]; other site 255470002691 L10 interface [polypeptide binding]; other site 255470002692 L11 interface [polypeptide binding]; other site 255470002693 putative EF-Tu interaction site [polypeptide binding]; other site 255470002694 putative EF-G interaction site [polypeptide binding]; other site 255470002695 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 255470002696 23S rRNA interface [nucleotide binding]; other site 255470002697 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 255470002698 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 255470002699 mRNA/rRNA interface [nucleotide binding]; other site 255470002700 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 255470002701 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 255470002702 23S rRNA interface [nucleotide binding]; other site 255470002703 L7/L12 interface [polypeptide binding]; other site 255470002704 putative thiostrepton binding site; other site 255470002705 L25 interface [polypeptide binding]; other site 255470002706 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 255470002707 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 255470002708 putative homodimer interface [polypeptide binding]; other site 255470002709 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 255470002710 heterodimer interface [polypeptide binding]; other site 255470002711 homodimer interface [polypeptide binding]; other site 255470002712 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 255470002713 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 255470002714 elongation factor Tu; Reviewed; Region: PRK00049 255470002715 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 255470002716 G1 box; other site 255470002717 GEF interaction site [polypeptide binding]; other site 255470002718 GTP/Mg2+ binding site [chemical binding]; other site 255470002719 Switch I region; other site 255470002720 G2 box; other site 255470002721 G3 box; other site 255470002722 Switch II region; other site 255470002723 G4 box; other site 255470002724 G5 box; other site 255470002725 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 255470002726 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 255470002727 Antibiotic Binding Site [chemical binding]; other site 255470002728 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 255470002729 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 255470002730 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 255470002731 putative ADP-binding pocket [chemical binding]; other site 255470002732 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 255470002733 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 255470002734 dimerization interface [polypeptide binding]; other site 255470002735 putative DNA binding site [nucleotide binding]; other site 255470002736 putative Zn2+ binding site [ion binding]; other site 255470002737 Predicted permease; Region: DUF318; cl17795 255470002738 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 255470002739 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 255470002740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 255470002741 Major Facilitator Superfamily; Region: MFS_1; pfam07690 255470002742 putative substrate translocation pore; other site 255470002743 4Fe-4S binding domain; Region: Fer4_5; pfam12801 255470002744 HPP family; Region: HPP; pfam04982 255470002745 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 255470002746 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 255470002747 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 255470002748 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 255470002749 acyl-activating enzyme (AAE) consensus motif; other site 255470002750 AMP binding site [chemical binding]; other site 255470002751 active site 255470002752 CoA binding site [chemical binding]; other site 255470002753 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470002754 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 255470002755 putative active site [active] 255470002756 heme pocket [chemical binding]; other site 255470002757 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470002758 putative active site [active] 255470002759 heme pocket [chemical binding]; other site 255470002760 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470002761 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 255470002762 putative active site [active] 255470002763 heme pocket [chemical binding]; other site 255470002764 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470002765 putative active site [active] 255470002766 heme pocket [chemical binding]; other site 255470002767 PAS domain S-box; Region: sensory_box; TIGR00229 255470002768 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470002769 putative active site [active] 255470002770 heme pocket [chemical binding]; other site 255470002771 PAS domain S-box; Region: sensory_box; TIGR00229 255470002772 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470002773 putative active site [active] 255470002774 heme pocket [chemical binding]; other site 255470002775 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 255470002776 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470002777 putative active site [active] 255470002778 heme pocket [chemical binding]; other site 255470002779 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 255470002780 dimer interface [polypeptide binding]; other site 255470002781 phosphorylation site [posttranslational modification] 255470002782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 255470002783 ATP binding site [chemical binding]; other site 255470002784 Mg2+ binding site [ion binding]; other site 255470002785 G-X-G motif; other site 255470002786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 255470002787 active site 255470002788 phosphorylation site [posttranslational modification] 255470002789 intermolecular recognition site; other site 255470002790 dimerization interface [polypeptide binding]; other site 255470002791 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 255470002792 ribonuclease III; Reviewed; Region: rnc; PRK00102 255470002793 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 255470002794 dimerization interface [polypeptide binding]; other site 255470002795 active site 255470002796 metal binding site [ion binding]; metal-binding site 255470002797 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 255470002798 dsRNA binding site [nucleotide binding]; other site 255470002799 acylphosphatase; Provisional; Region: PRK14450 255470002800 Domain of unknown function (DUF362); Region: DUF362; pfam04015 255470002801 multifunctional aminopeptidase A; Provisional; Region: PRK00913 255470002802 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 255470002803 interface (dimer of trimers) [polypeptide binding]; other site 255470002804 Substrate-binding/catalytic site; other site 255470002805 Zn-binding sites [ion binding]; other site 255470002806 AAA domain; Region: AAA_33; pfam13671 255470002807 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 255470002808 active site 255470002809 EDD domain protein, DegV family; Region: DegV; TIGR00762 255470002810 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 255470002811 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 255470002812 acyl-activating enzyme (AAE) consensus motif; other site 255470002813 active site 255470002814 AMP binding site [chemical binding]; other site 255470002815 CoA binding site [chemical binding]; other site 255470002816 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 255470002817 pyridoxal 5'-phosphate binding site [chemical binding]; other site 255470002818 catalytic residue [active] 255470002819 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 255470002820 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 255470002821 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 255470002822 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 255470002823 protein binding site [polypeptide binding]; other site 255470002824 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 255470002825 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 255470002826 active site 255470002827 HIGH motif; other site 255470002828 nucleotide binding site [chemical binding]; other site 255470002829 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 255470002830 active site 255470002831 KMSKS motif; other site 255470002832 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 255470002833 tRNA binding surface [nucleotide binding]; other site 255470002834 anticodon binding site; other site 255470002835 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 255470002836 G-X-X-G motif; other site 255470002837 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 255470002838 RxxxH motif; other site 255470002839 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 255470002840 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 255470002841 PQQ-like domain; Region: PQQ_2; pfam13360 255470002842 Trp docking motif [polypeptide binding]; other site 255470002843 PQQ-like domain; Region: PQQ_2; pfam13360 255470002844 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 255470002845 Trp docking motif [polypeptide binding]; other site 255470002846 active site 255470002847 Ribonuclease P; Region: Ribonuclease_P; pfam00825 255470002848 Ribosomal protein L34; Region: Ribosomal_L34; pfam00468 255470002849 30S ribosomal protein S18; Provisional; Region: PRK13400 255470002850 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 255470002851 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 255470002852 dimer interface [polypeptide binding]; other site 255470002853 ssDNA binding site [nucleotide binding]; other site 255470002854 tetramer (dimer of dimers) interface [polypeptide binding]; other site 255470002855 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 255470002856 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 255470002857 homotrimer interaction site [polypeptide binding]; other site 255470002858 putative active site [active] 255470002859 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 255470002860 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 255470002861 nucleotide binding site [chemical binding]; other site 255470002862 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 255470002863 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 255470002864 Walker A/P-loop; other site 255470002865 ATP binding site [chemical binding]; other site 255470002866 Q-loop/lid; other site 255470002867 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 255470002868 Q-loop/lid; other site 255470002869 ABC transporter signature motif; other site 255470002870 Walker B; other site 255470002871 D-loop; other site 255470002872 H-loop/switch region; other site 255470002873 EamA-like transporter family; Region: EamA; pfam00892 255470002874 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 255470002875 EamA-like transporter family; Region: EamA; pfam00892 255470002876 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 255470002877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 255470002878 active site 255470002879 phosphorylation site [posttranslational modification] 255470002880 intermolecular recognition site; other site 255470002881 dimerization interface [polypeptide binding]; other site 255470002882 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 255470002883 DNA binding site [nucleotide binding] 255470002884 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 255470002885 dimerization interface [polypeptide binding]; other site 255470002886 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 255470002887 dimer interface [polypeptide binding]; other site 255470002888 phosphorylation site [posttranslational modification] 255470002889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 255470002890 ATP binding site [chemical binding]; other site 255470002891 Mg2+ binding site [ion binding]; other site 255470002892 G-X-G motif; other site 255470002893 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 255470002894 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 255470002895 Walker A/P-loop; other site 255470002896 ATP binding site [chemical binding]; other site 255470002897 Q-loop/lid; other site 255470002898 ABC transporter signature motif; other site 255470002899 Walker B; other site 255470002900 D-loop; other site 255470002901 H-loop/switch region; other site 255470002902 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 255470002903 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 255470002904 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 255470002905 Walker A/P-loop; other site 255470002906 ATP binding site [chemical binding]; other site 255470002907 Q-loop/lid; other site 255470002908 ABC transporter signature motif; other site 255470002909 Walker B; other site 255470002910 D-loop; other site 255470002911 H-loop/switch region; other site 255470002912 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 255470002913 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 255470002914 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 255470002915 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 255470002916 dimer interface [polypeptide binding]; other site 255470002917 conserved gate region; other site 255470002918 putative PBP binding loops; other site 255470002919 ABC-ATPase subunit interface; other site 255470002920 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 255470002921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 255470002922 dimer interface [polypeptide binding]; other site 255470002923 conserved gate region; other site 255470002924 putative PBP binding loops; other site 255470002925 ABC-ATPase subunit interface; other site 255470002926 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 255470002927 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 255470002928 peptide binding site [polypeptide binding]; other site 255470002929 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 255470002930 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 255470002931 Beta-Casp domain; Region: Beta-Casp; smart01027 255470002932 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 255470002933 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 255470002934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 255470002935 active site 255470002936 phosphorylation site [posttranslational modification] 255470002937 intermolecular recognition site; other site 255470002938 dimerization interface [polypeptide binding]; other site 255470002939 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 255470002940 DNA binding residues [nucleotide binding] 255470002941 dimerization interface [polypeptide binding]; other site 255470002942 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470002943 PAS domain; Region: PAS_9; pfam13426 255470002944 putative active site [active] 255470002945 heme pocket [chemical binding]; other site 255470002946 PAS fold; Region: PAS_4; pfam08448 255470002947 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470002948 putative active site [active] 255470002949 heme pocket [chemical binding]; other site 255470002950 GAF domain; Region: GAF_2; pfam13185 255470002951 PAS domain S-box; Region: sensory_box; TIGR00229 255470002952 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470002953 putative active site [active] 255470002954 heme pocket [chemical binding]; other site 255470002955 PAS domain; Region: PAS; smart00091 255470002956 PAS domain; Region: PAS_9; pfam13426 255470002957 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 255470002958 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470002959 putative active site [active] 255470002960 heme pocket [chemical binding]; other site 255470002961 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470002962 putative active site [active] 255470002963 heme pocket [chemical binding]; other site 255470002964 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 255470002965 Histidine kinase; Region: HisKA_3; pfam07730 255470002966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 255470002967 ATP binding site [chemical binding]; other site 255470002968 Mg2+ binding site [ion binding]; other site 255470002969 G-X-G motif; other site 255470002970 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 255470002971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 255470002972 S-adenosylmethionine binding site [chemical binding]; other site 255470002973 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 255470002974 active site clefts [active] 255470002975 zinc binding site [ion binding]; other site 255470002976 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 255470002977 active site 255470002978 dimer interface [polypeptide binding]; other site 255470002979 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 255470002980 NAD synthetase; Provisional; Region: PRK13981 255470002981 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 255470002982 multimer interface [polypeptide binding]; other site 255470002983 active site 255470002984 catalytic triad [active] 255470002985 protein interface 1 [polypeptide binding]; other site 255470002986 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 255470002987 homodimer interface [polypeptide binding]; other site 255470002988 NAD binding pocket [chemical binding]; other site 255470002989 ATP binding pocket [chemical binding]; other site 255470002990 Mg binding site [ion binding]; other site 255470002991 active-site loop [active] 255470002992 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 255470002993 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 255470002994 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 255470002995 Nitrogen regulatory protein P-II; Region: P-II; smart00938 255470002996 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 255470002997 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 255470002998 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 255470002999 DNA binding site [nucleotide binding] 255470003000 Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981 255470003001 putative subunit interface; other site 255470003002 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 255470003003 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 255470003004 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 255470003005 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 255470003006 active site 255470003007 FMN binding site [chemical binding]; other site 255470003008 substrate binding site [chemical binding]; other site 255470003009 3Fe-4S cluster binding site [ion binding]; other site 255470003010 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 255470003011 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 255470003012 substrate binding site [chemical binding]; other site 255470003013 glutamase interaction surface [polypeptide binding]; other site 255470003014 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 255470003015 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 255470003016 putative active site [active] 255470003017 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 255470003018 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 255470003019 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 255470003020 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 255470003021 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 255470003022 putative active site [active] 255470003023 oxyanion strand; other site 255470003024 catalytic triad [active] 255470003025 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 255470003026 Predicted membrane protein [Function unknown]; Region: COG1971 255470003027 Domain of unknown function DUF; Region: DUF204; pfam02659 255470003028 Domain of unknown function DUF; Region: DUF204; pfam02659 255470003029 cysteine synthase; Region: PLN02565 255470003030 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 255470003031 dimer interface [polypeptide binding]; other site 255470003032 pyridoxal 5'-phosphate binding site [chemical binding]; other site 255470003033 catalytic residue [active] 255470003034 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 255470003035 FeS/SAM binding site; other site 255470003036 Radical SAM superfamily; Region: Radical_SAM; pfam04055 255470003037 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 255470003038 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 255470003039 Walker A motif; other site 255470003040 homodimer interface [polypeptide binding]; other site 255470003041 ATP binding site [chemical binding]; other site 255470003042 hydroxycobalamin binding site [chemical binding]; other site 255470003043 Walker B motif; other site 255470003044 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 255470003045 active site 255470003046 catalytic triad [active] 255470003047 dimer interface [polypeptide binding]; other site 255470003048 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 255470003049 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 255470003050 DXD motif; other site 255470003051 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 255470003052 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 255470003053 NodB motif; other site 255470003054 active site 255470003055 catalytic site [active] 255470003056 metal binding site [ion binding]; metal-binding site 255470003057 Protease prsW family; Region: PrsW-protease; pfam13367 255470003058 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 255470003059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 255470003060 active site 255470003061 phosphorylation site [posttranslational modification] 255470003062 intermolecular recognition site; other site 255470003063 dimerization interface [polypeptide binding]; other site 255470003064 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 255470003065 DNA binding residues [nucleotide binding] 255470003066 dimerization interface [polypeptide binding]; other site 255470003067 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 255470003068 CoA binding domain; Region: CoA_binding_2; pfam13380 255470003069 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 255470003070 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 255470003071 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 255470003072 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 255470003073 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 255470003074 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 255470003075 metal binding site 2 [ion binding]; metal-binding site 255470003076 putative DNA binding helix; other site 255470003077 metal binding site 1 [ion binding]; metal-binding site 255470003078 dimer interface [polypeptide binding]; other site 255470003079 structural Zn2+ binding site [ion binding]; other site 255470003080 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 255470003081 Predicted transcriptional regulators [Transcription]; Region: COG1695 255470003082 Transcriptional regulators [Transcription]; Region: MarR; COG1846 255470003083 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 255470003084 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 255470003085 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 255470003086 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 255470003087 Walker A/P-loop; other site 255470003088 ATP binding site [chemical binding]; other site 255470003089 Q-loop/lid; other site 255470003090 ABC transporter signature motif; other site 255470003091 Walker B; other site 255470003092 D-loop; other site 255470003093 H-loop/switch region; other site 255470003094 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 255470003095 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 255470003096 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 255470003097 Walker A/P-loop; other site 255470003098 ATP binding site [chemical binding]; other site 255470003099 Q-loop/lid; other site 255470003100 ABC transporter signature motif; other site 255470003101 Walker B; other site 255470003102 D-loop; other site 255470003103 H-loop/switch region; other site 255470003104 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 255470003105 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 255470003106 Transcriptional regulators [Transcription]; Region: MarR; COG1846 255470003107 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 255470003108 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 255470003109 reductive dehalogenase; Region: RDH; TIGR02486 255470003110 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 255470003111 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 255470003112 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 255470003113 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 255470003114 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 255470003115 BioY family; Region: BioY; pfam02632 255470003116 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cd01342 255470003117 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 255470003118 homopentamer interface [polypeptide binding]; other site 255470003119 active site 255470003120 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 255470003121 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 255470003122 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 255470003123 dimerization interface [polypeptide binding]; other site 255470003124 active site 255470003125 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 255470003126 Lumazine binding domain; Region: Lum_binding; pfam00677 255470003127 Lumazine binding domain; Region: Lum_binding; pfam00677 255470003128 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 255470003129 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 255470003130 catalytic motif [active] 255470003131 Zn binding site [ion binding]; other site 255470003132 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 255470003133 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 255470003134 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 255470003135 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 255470003136 Catalytic site [active] 255470003137 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 255470003138 active site 255470003139 Endonuclease related to archaeal Holliday junction resolvase; Region: Endonuc_Holl; pfam10107 255470003140 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 255470003141 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 255470003142 ATP binding site [chemical binding]; other site 255470003143 Mg2+ binding site [ion binding]; other site 255470003144 G-X-G motif; other site 255470003145 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 255470003146 ATP binding site [chemical binding]; other site 255470003147 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 255470003148 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 255470003149 Part of AAA domain; Region: AAA_19; pfam13245 255470003150 AAA domain; Region: AAA_12; pfam13087 255470003151 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 255470003152 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 255470003153 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 255470003154 active site 255470003155 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 255470003156 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 255470003157 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 255470003158 dihydroorotase; Validated; Region: pyrC; PRK09357 255470003159 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 255470003160 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 255470003161 active site 255470003162 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 255470003163 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 255470003164 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 255470003165 catalytic site [active] 255470003166 subunit interface [polypeptide binding]; other site 255470003167 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 255470003168 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 255470003169 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 255470003170 Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787 255470003171 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 255470003172 ATP-grasp domain; Region: ATP-grasp_4; cl17255 255470003173 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 255470003174 IMP binding site; other site 255470003175 dimer interface [polypeptide binding]; other site 255470003176 interdomain contacts; other site 255470003177 partial ornithine binding site; other site 255470003178 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 255470003179 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 255470003180 FAD binding pocket [chemical binding]; other site 255470003181 FAD binding motif [chemical binding]; other site 255470003182 phosphate binding motif [ion binding]; other site 255470003183 beta-alpha-beta structure motif; other site 255470003184 NAD binding pocket [chemical binding]; other site 255470003185 Iron coordination center [ion binding]; other site 255470003186 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 255470003187 active site 255470003188 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 255470003189 homodimer interface [polypeptide binding]; other site 255470003190 pyridoxal 5'-phosphate binding site [chemical binding]; other site 255470003191 catalytic residue [active] 255470003192 homoserine dehydrogenase; Provisional; Region: PRK06349 255470003193 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 255470003194 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 255470003195 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 255470003196 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 255470003197 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 255470003198 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 255470003199 active site 255470003200 Substrate binding site; other site 255470003201 Mg++ binding site; other site 255470003202 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 255470003203 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 255470003204 acetyl-CoA synthetase; Provisional; Region: PRK00174 255470003205 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 255470003206 active site 255470003207 CoA binding site [chemical binding]; other site 255470003208 acyl-activating enzyme (AAE) consensus motif; other site 255470003209 AMP binding site [chemical binding]; other site 255470003210 acetate binding site [chemical binding]; other site 255470003211 peptide chain release factor 1; Validated; Region: prfA; PRK00591 255470003212 PCRF domain; Region: PCRF; pfam03462 255470003213 RF-1 domain; Region: RF-1; pfam00472 255470003214 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 255470003215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 255470003216 S-adenosylmethionine binding site [chemical binding]; other site 255470003217 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 255470003218 elongation factor G; Reviewed; Region: PRK12740 255470003219 G1 box; other site 255470003220 putative GEF interaction site [polypeptide binding]; other site 255470003221 GTP/Mg2+ binding site [chemical binding]; other site 255470003222 Switch I region; other site 255470003223 G2 box; other site 255470003224 G3 box; other site 255470003225 Switch II region; other site 255470003226 G4 box; other site 255470003227 G5 box; other site 255470003228 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 255470003229 Elongation Factor G, domain II; Region: EFG_II; pfam14492 255470003230 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 255470003231 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 255470003232 Integral membrane protein DUF95; Region: DUF95; pfam01944 255470003233 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 255470003234 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 255470003235 active site 255470003236 Int/Topo IB signature motif; other site 255470003237 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 255470003238 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 255470003239 GIY-YIG motif/motif A; other site 255470003240 active site 255470003241 catalytic site [active] 255470003242 putative DNA binding site [nucleotide binding]; other site 255470003243 metal binding site [ion binding]; metal-binding site 255470003244 UvrB/uvrC motif; Region: UVR; pfam02151 255470003245 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 255470003246 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 255470003247 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 255470003248 Coenzyme A binding pocket [chemical binding]; other site 255470003249 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 255470003250 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 255470003251 active site 255470003252 motif I; other site 255470003253 motif II; other site 255470003254 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 255470003255 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 255470003256 MutS domain I; Region: MutS_I; pfam01624 255470003257 MutS domain II; Region: MutS_II; pfam05188 255470003258 MutS domain III; Region: MutS_III; pfam05192 255470003259 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 255470003260 Walker A/P-loop; other site 255470003261 ATP binding site [chemical binding]; other site 255470003262 Q-loop/lid; other site 255470003263 ABC transporter signature motif; other site 255470003264 Walker B; other site 255470003265 D-loop; other site 255470003266 H-loop/switch region; other site 255470003267 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 255470003268 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 255470003269 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 255470003270 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 255470003271 Fructose-1,6-bisphosphatase; Region: FBPase_3; pfam01950 255470003272 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 255470003273 active site 255470003274 dimerization interface [polypeptide binding]; other site 255470003275 DNA polymerase III subunit beta; Validated; Region: PRK05643 255470003276 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 255470003277 putative DNA binding surface [nucleotide binding]; other site 255470003278 dimer interface [polypeptide binding]; other site 255470003279 beta-clamp/clamp loader binding surface; other site 255470003280 beta-clamp/translesion DNA polymerase binding surface; other site 255470003281 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 255470003282 Domain of unknown function (DU1801); Region: DUF1801; cl17490 255470003283 Putative lysophospholipase; Region: Hydrolase_4; cl19140 255470003284 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 255470003285 Smr domain; Region: Smr; pfam01713 255470003286 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 255470003287 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 255470003288 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 255470003289 putative active site [active] 255470003290 putative substrate binding site [chemical binding]; other site 255470003291 putative cosubstrate binding site; other site 255470003292 catalytic site [active] 255470003293 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 255470003294 active site 255470003295 arsenical-resistance protein; Region: acr3; TIGR00832 255470003296 methionine sulfoxide reductase A; Provisional; Region: PRK14054 255470003297 methionine sulfoxide reductase B; Provisional; Region: PRK05508 255470003298 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 255470003299 TfoX N-terminal domain; Region: TfoX_N; pfam04993 255470003300 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 255470003301 dimerization interface [polypeptide binding]; other site 255470003302 putative DNA binding site [nucleotide binding]; other site 255470003303 putative Zn2+ binding site [ion binding]; other site 255470003304 Predicted integral membrane protein [Function unknown]; Region: COG5658 255470003305 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 255470003306 SdpI/YhfL protein family; Region: SdpI; pfam13630 255470003307 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 255470003308 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 255470003309 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 255470003310 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 255470003311 Walker A motif; other site 255470003312 ATP binding site [chemical binding]; other site 255470003313 Walker B motif; other site 255470003314 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 255470003315 heterotetramer interface [polypeptide binding]; other site 255470003316 active site pocket [active] 255470003317 cleavage site 255470003318 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 255470003319 nucleotide binding site [chemical binding]; other site 255470003320 N-acetyl-L-glutamate binding site [chemical binding]; other site 255470003321 acetylornithine aminotransferase; Provisional; Region: PRK02627 255470003322 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 255470003323 inhibitor-cofactor binding pocket; inhibition site 255470003324 pyridoxal 5'-phosphate binding site [chemical binding]; other site 255470003325 catalytic residue [active] 255470003326 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 255470003327 ANP binding site [chemical binding]; other site 255470003328 Substrate Binding Site II [chemical binding]; other site 255470003329 Substrate Binding Site I [chemical binding]; other site 255470003330 argininosuccinate lyase; Provisional; Region: PRK00855 255470003331 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 255470003332 active sites [active] 255470003333 tetramer interface [polypeptide binding]; other site 255470003334 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 255470003335 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 255470003336 DAK2 domain; Region: Dak2; pfam02734 255470003337 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 255470003338 EDD domain protein, DegV family; Region: DegV; TIGR00762 255470003339 EDD domain protein, DegV family; Region: DegV; TIGR00762 255470003340 EDD domain protein, DegV family; Region: DegV; TIGR00762 255470003341 EDD domain protein, DegV family; Region: DegV; TIGR00762 255470003342 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 255470003343 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 255470003344 generic binding surface II; other site 255470003345 ssDNA binding site; other site 255470003346 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 255470003347 ATP binding site [chemical binding]; other site 255470003348 putative Mg++ binding site [ion binding]; other site 255470003349 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 255470003350 nucleotide binding region [chemical binding]; other site 255470003351 ATP-binding site [chemical binding]; other site 255470003352 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 255470003353 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 255470003354 Zn2+ binding site [ion binding]; other site 255470003355 Mg2+ binding site [ion binding]; other site 255470003356 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 255470003357 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 255470003358 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 255470003359 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 255470003360 active site 255470003361 HIGH motif; other site 255470003362 KMSK motif region; other site 255470003363 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 255470003364 tRNA binding surface [nucleotide binding]; other site 255470003365 anticodon binding site; other site 255470003366 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 255470003367 AsnC family; Region: AsnC_trans_reg; pfam01037 255470003368 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 255470003369 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 255470003370 NAD binding site [chemical binding]; other site 255470003371 homotetramer interface [polypeptide binding]; other site 255470003372 homodimer interface [polypeptide binding]; other site 255470003373 substrate binding site [chemical binding]; other site 255470003374 active site 255470003375 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 255470003376 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 255470003377 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 255470003378 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 255470003379 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 255470003380 NAD(P) binding site [chemical binding]; other site 255470003381 homotetramer interface [polypeptide binding]; other site 255470003382 homodimer interface [polypeptide binding]; other site 255470003383 active site 255470003384 transcription antitermination factor NusB; Region: nusB; TIGR01951 255470003385 putative RNA binding site [nucleotide binding]; other site 255470003386 acyl carrier protein; Provisional; Region: acpP; PRK00982 255470003387 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 255470003388 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 255470003389 B12 binding site [chemical binding]; other site 255470003390 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 255470003391 FeS/SAM binding site; other site 255470003392 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 255470003393 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 255470003394 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 255470003395 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 255470003396 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 255470003397 ATP binding site [chemical binding]; other site 255470003398 putative Mg++ binding site [ion binding]; other site 255470003399 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 255470003400 nucleotide binding region [chemical binding]; other site 255470003401 ATP-binding site [chemical binding]; other site 255470003402 TRCF domain; Region: TRCF; pfam03461 255470003403 gamma-glutamyl kinase; Provisional; Region: PRK05429 255470003404 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 255470003405 nucleotide binding site [chemical binding]; other site 255470003406 homotetrameric interface [polypeptide binding]; other site 255470003407 putative phosphate binding site [ion binding]; other site 255470003408 putative allosteric binding site; other site 255470003409 PUA domain; Region: PUA; pfam01472 255470003410 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 255470003411 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 255470003412 protein binding site [polypeptide binding]; other site 255470003413 FlxA-like protein; Region: FlxA; pfam14282 255470003414 Trypsin; Region: Trypsin; pfam00089 255470003415 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 255470003416 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 255470003417 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 255470003418 DNA binding residues [nucleotide binding] 255470003419 dimer interface [polypeptide binding]; other site 255470003420 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 255470003421 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 255470003422 putative catalytic cysteine [active] 255470003423 ribonuclease PH; Reviewed; Region: rph; PRK00173 255470003424 Ribonuclease PH; Region: RNase_PH_bact; cd11362 255470003425 hexamer interface [polypeptide binding]; other site 255470003426 active site 255470003427 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 255470003428 nudix motif; other site 255470003429 Competence-damaged protein; Region: CinA; pfam02464 255470003430 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 255470003431 PAS domain S-box; Region: sensory_box; TIGR00229 255470003432 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 255470003433 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 255470003434 dimer interface [polypeptide binding]; other site 255470003435 phosphorylation site [posttranslational modification] 255470003436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 255470003437 ATP binding site [chemical binding]; other site 255470003438 Mg2+ binding site [ion binding]; other site 255470003439 G-X-G motif; other site 255470003440 Helix-turn-helix domain; Region: HTH_17; pfam12728 255470003441 Response regulator receiver domain; Region: Response_reg; pfam00072 255470003442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 255470003443 active site 255470003444 phosphorylation site [posttranslational modification] 255470003445 intermolecular recognition site; other site 255470003446 dimerization interface [polypeptide binding]; other site 255470003447 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 255470003448 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 255470003449 Probable zinc-binding domain; Region: zf-trcl; pfam13451 255470003450 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 255470003451 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 255470003452 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 255470003453 G1 box; other site 255470003454 putative GEF interaction site [polypeptide binding]; other site 255470003455 GTP/Mg2+ binding site [chemical binding]; other site 255470003456 Switch I region; other site 255470003457 G2 box; other site 255470003458 G3 box; other site 255470003459 Switch II region; other site 255470003460 G4 box; other site 255470003461 G5 box; other site 255470003462 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 255470003463 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 255470003464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 255470003465 metabolite-proton symporter; Region: 2A0106; TIGR00883 255470003466 putative substrate translocation pore; other site 255470003467 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 255470003468 Ligand Binding Site [chemical binding]; other site 255470003469 Protein of unknown function (DUF502); Region: DUF502; cl01107 255470003470 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 255470003471 Fasciclin domain; Region: Fasciclin; pfam02469 255470003472 Glycosyl transferase 4-like; Region: Glyco_trans_4_2; pfam13477 255470003473 Uncharacterized conserved protein [Function unknown]; Region: COG3422 255470003474 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 255470003475 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 255470003476 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 255470003477 recombination factor protein RarA; Reviewed; Region: PRK13342 255470003478 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 255470003479 Walker A motif; other site 255470003480 ATP binding site [chemical binding]; other site 255470003481 Walker B motif; other site 255470003482 arginine finger; other site 255470003483 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 255470003484 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 255470003485 putative ligand binding pocket/active site [active] 255470003486 putative metal binding site [ion binding]; other site 255470003487 AMMECR1; Region: AMMECR1; pfam01871 255470003488 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 255470003489 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 255470003490 FeS/SAM binding site; other site 255470003491 EamA-like transporter family; Region: EamA; pfam00892 255470003492 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 255470003493 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 255470003494 Renin receptor-like protein; Region: Renin_r; pfam07850 255470003495 YcxB-like protein; Region: YcxB; pfam14317 255470003496 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 255470003497 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 255470003498 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 255470003499 Walker A/P-loop; other site 255470003500 Walker A/P-loop; other site 255470003501 ATP binding site [chemical binding]; other site 255470003502 ATP binding site [chemical binding]; other site 255470003503 Q-loop/lid; other site 255470003504 ABC transporter signature motif; other site 255470003505 Walker B; other site 255470003506 D-loop; other site 255470003507 H-loop/switch region; other site 255470003508 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 255470003509 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 255470003510 Coenzyme A binding pocket [chemical binding]; other site 255470003511 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 255470003512 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 255470003513 CoA-binding site [chemical binding]; other site 255470003514 ATP-binding [chemical binding]; other site 255470003515 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 255470003516 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 255470003517 NAD(P) binding site [chemical binding]; other site 255470003518 active site 255470003519 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 255470003520 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 255470003521 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 255470003522 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 255470003523 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 255470003524 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 255470003525 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 255470003526 Coenzyme A binding pocket [chemical binding]; other site 255470003527 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 255470003528 catalytic residues [active] 255470003529 Protein of unknown function (DUF2769); Region: DUF2769; pfam10967 255470003530 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 255470003531 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 255470003532 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 255470003533 Predicted membrane protein (DUF2178); Region: DUF2178; pfam09946 255470003534 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 255470003535 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 255470003536 non-specific DNA binding site [nucleotide binding]; other site 255470003537 salt bridge; other site 255470003538 sequence-specific DNA binding site [nucleotide binding]; other site 255470003539 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 255470003540 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 255470003541 Walker A/P-loop; other site 255470003542 ATP binding site [chemical binding]; other site 255470003543 Q-loop/lid; other site 255470003544 ABC transporter signature motif; other site 255470003545 Walker B; other site 255470003546 D-loop; other site 255470003547 H-loop/switch region; other site 255470003548 Acyltransferase family; Region: Acyl_transf_3; cl19154 255470003549 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 255470003550 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 255470003551 hypothetical protein; Validated; Region: PRK07682 255470003552 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 255470003553 pyridoxal 5'-phosphate binding site [chemical binding]; other site 255470003554 homodimer interface [polypeptide binding]; other site 255470003555 catalytic residue [active] 255470003556 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 255470003557 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 255470003558 active site 255470003559 HIGH motif; other site 255470003560 dimer interface [polypeptide binding]; other site 255470003561 KMSKS motif; other site 255470003562 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 255470003563 Fe-S cluster binding site [ion binding]; other site 255470003564 substrate binding site [chemical binding]; other site 255470003565 catalytic site [active] 255470003566 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12858 255470003567 catalytic residue [active] 255470003568 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 255470003569 putative substrate binding site [chemical binding]; other site 255470003570 putative ATP binding site [chemical binding]; other site 255470003571 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 255470003572 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 255470003573 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 255470003574 DNA binding residues [nucleotide binding] 255470003575 Helix-turn-helix domain; Region: HTH_17; pfam12728 255470003576 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 255470003577 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 255470003578 active site 255470003579 phosphorylation site [posttranslational modification] 255470003580 intermolecular recognition site; other site 255470003581 dimerization interface [polypeptide binding]; other site 255470003582 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 255470003583 DNA binding residues [nucleotide binding] 255470003584 dimerization interface [polypeptide binding]; other site 255470003585 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 255470003586 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 255470003587 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 255470003588 Walker A motif; other site 255470003589 ATP binding site [chemical binding]; other site 255470003590 Walker B motif; other site 255470003591 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 255470003592 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 255470003593 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 255470003594 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 255470003595 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 255470003596 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 255470003597 type II secretion system protein J; Region: gspJ; TIGR01711 255470003598 PilX N-terminal; Region: PilX_N; pfam14341 255470003599 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 255470003600 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 255470003601 Walker A motif; other site 255470003602 ATP binding site [chemical binding]; other site 255470003603 Walker B motif; other site 255470003604 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 255470003605 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 255470003606 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 255470003607 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 255470003608 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 255470003609 bifunctional mannosyl-3-phosphoglycerate synthase/mannosyl-3 phosphoglycerate phosphatase; Provisional; Region: PRK14502 255470003610 Mannosyl-3-phosphoglycerate synthase (osmo_MPGsynth); Region: Osmo_MPGsynth; pfam09488 255470003611 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 255470003612 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 255470003613 active site 255470003614 motif I; other site 255470003615 motif II; other site 255470003616 RDD family; Region: RDD; pfam06271 255470003617 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 255470003618 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 255470003619 active site 255470003620 HIGH motif; other site 255470003621 KMSKS motif; other site 255470003622 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 255470003623 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 255470003624 FeS/SAM binding site; other site 255470003625 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 255470003626 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 255470003627 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 255470003628 heterodimer interface [polypeptide binding]; other site 255470003629 active site 255470003630 FMN binding site [chemical binding]; other site 255470003631 homodimer interface [polypeptide binding]; other site 255470003632 substrate binding site [chemical binding]; other site 255470003633 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 255470003634 lipoprotein signal peptidase; Provisional; Region: PRK14784 255470003635 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 255470003636 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 255470003637 RNA binding surface [nucleotide binding]; other site 255470003638 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 255470003639 active site 255470003640 Winged helix-turn-helix; Region: HTH_45; pfam14947 255470003641 Phospholipid methyltransferase; Region: PEMT; cl17370 255470003642 GH3 auxin-responsive promoter; Region: GH3; pfam03321 255470003643 indole-3-acetic acid-amido synthetase; Region: PLN02249 255470003644 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cd03493 255470003645 proximal heme binding site [chemical binding]; other site 255470003646 Iron-sulfur protein interface; other site 255470003647 GAF domain; Region: GAF_2; pfam13185 255470003648 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 255470003649 metal binding site [ion binding]; metal-binding site 255470003650 active site 255470003651 I-site; other site 255470003652 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 255470003653 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 255470003654 Zn2+ binding site [ion binding]; other site 255470003655 Mg2+ binding site [ion binding]; other site 255470003656 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 255470003657 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 255470003658 dimerization interface [polypeptide binding]; other site 255470003659 active site 255470003660 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 255470003661 L-aspartate oxidase; Provisional; Region: PRK06175 255470003662 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 255470003663 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 255470003664 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14336 255470003665 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 255470003666 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 255470003667 FeS/SAM binding site; other site 255470003668 TRAM domain; Region: TRAM; pfam01938 255470003669 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 255470003670 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 255470003671 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 255470003672 DNA binding site [nucleotide binding] 255470003673 catalytic residue [active] 255470003674 H2TH interface [polypeptide binding]; other site 255470003675 putative catalytic residues [active] 255470003676 turnover-facilitating residue; other site 255470003677 intercalation triad [nucleotide binding]; other site 255470003678 8OG recognition residue [nucleotide binding]; other site 255470003679 putative reading head residues; other site 255470003680 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 255470003681 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 255470003682 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 255470003683 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 255470003684 active site 255470003685 DNA polymerase I; Provisional; Region: PRK05755 255470003686 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 255470003687 active site 255470003688 metal binding site 1 [ion binding]; metal-binding site 255470003689 putative 5' ssDNA interaction site; other site 255470003690 metal binding site 3; metal-binding site 255470003691 metal binding site 2 [ion binding]; metal-binding site 255470003692 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 255470003693 putative DNA binding site [nucleotide binding]; other site 255470003694 putative metal binding site [ion binding]; other site 255470003695 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 255470003696 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 255470003697 active site 255470003698 DNA binding site [nucleotide binding] 255470003699 catalytic site [active] 255470003700 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 255470003701 active site residue [active] 255470003702 ornithine carbamoyltransferase; Provisional; Region: PRK00779 255470003703 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 255470003704 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 255470003705 GTP-binding protein Der; Reviewed; Region: PRK00093 255470003706 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 255470003707 G1 box; other site 255470003708 GTP/Mg2+ binding site [chemical binding]; other site 255470003709 Switch I region; other site 255470003710 G2 box; other site 255470003711 Switch II region; other site 255470003712 G3 box; other site 255470003713 G4 box; other site 255470003714 G5 box; other site 255470003715 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 255470003716 G1 box; other site 255470003717 GTP/Mg2+ binding site [chemical binding]; other site 255470003718 Switch I region; other site 255470003719 G2 box; other site 255470003720 G3 box; other site 255470003721 Switch II region; other site 255470003722 G4 box; other site 255470003723 G5 box; other site 255470003724 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 255470003725 membrane protein; Provisional; Region: PRK14415 255470003726 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 255470003727 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 255470003728 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 255470003729 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 255470003730 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 255470003731 HSP70 interaction site [polypeptide binding]; other site 255470003732 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 255470003733 substrate binding site [polypeptide binding]; other site 255470003734 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 255470003735 Zn binding sites [ion binding]; other site 255470003736 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 255470003737 dimer interface [polypeptide binding]; other site 255470003738 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 255470003739 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 255470003740 nucleotide binding site [chemical binding]; other site 255470003741 NEF interaction site [polypeptide binding]; other site 255470003742 SBD interface [polypeptide binding]; other site 255470003743 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 255470003744 dimer interface [polypeptide binding]; other site 255470003745 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 255470003746 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 255470003747 HrcA protein C terminal domain; Region: HrcA; pfam01628 255470003748 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 255470003749 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 255470003750 Caspase domain; Region: Peptidase_C14; pfam00656 255470003751 Peptidase C13 family; Region: Peptidase_C13; cl02159 255470003752 RNase_H superfamily; Region: RNase_H_2; pfam13482 255470003753 active site 255470003754 catalytic site [active] 255470003755 substrate binding site [chemical binding]; other site 255470003756 active site 255470003757 substrate binding site [chemical binding]; other site 255470003758 catalytic site [active] 255470003759 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 255470003760 transcription termination factor Rho; Provisional; Region: rho; PRK09376 255470003761 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 255470003762 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 255470003763 RNA binding site [nucleotide binding]; other site 255470003764 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 255470003765 Walker A motif; other site 255470003766 ATP binding site [chemical binding]; other site 255470003767 Walker B motif; other site 255470003768 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 255470003769 active site 255470003770 intersubunit interactions; other site 255470003771 catalytic residue [active] 255470003772 CTP synthetase; Validated; Region: pyrG; PRK05380 255470003773 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 255470003774 Catalytic site [active] 255470003775 active site 255470003776 UTP binding site [chemical binding]; other site 255470003777 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 255470003778 active site 255470003779 putative oxyanion hole; other site 255470003780 catalytic triad [active] 255470003781 chaperone protein DnaJ; Provisional; Region: PRK10767 255470003782 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 255470003783 HSP70 interaction site [polypeptide binding]; other site 255470003784 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 255470003785 substrate binding site [polypeptide binding]; other site 255470003786 dimer interface [polypeptide binding]; other site 255470003787 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 255470003788 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 255470003789 DNA binding residues [nucleotide binding] 255470003790 putative dimer interface [polypeptide binding]; other site 255470003791 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 255470003792 Clp amino terminal domain; Region: Clp_N; pfam02861 255470003793 Clp amino terminal domain; Region: Clp_N; pfam02861 255470003794 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 255470003795 Walker A motif; other site 255470003796 ATP binding site [chemical binding]; other site 255470003797 Walker B motif; other site 255470003798 arginine finger; other site 255470003799 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 255470003800 Walker A motif; other site 255470003801 ATP binding site [chemical binding]; other site 255470003802 Walker B motif; other site 255470003803 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 255470003804 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 255470003805 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 255470003806 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 255470003807 active site 255470003808 tetramer interface [polypeptide binding]; other site 255470003809 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 255470003810 active site 255470003811 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 255470003812 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 255470003813 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 255470003814 dimerization interface [polypeptide binding]; other site 255470003815 putative ATP binding site [chemical binding]; other site 255470003816 Methyltransferase domain; Region: Methyltransf_31; pfam13847 255470003817 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 255470003818 S-adenosylmethionine binding site [chemical binding]; other site 255470003819 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 255470003820 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 255470003821 purine monophosphate binding site [chemical binding]; other site 255470003822 dimer interface [polypeptide binding]; other site 255470003823 putative catalytic residues [active] 255470003824 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 255470003825 nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662 255470003826 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 255470003827 active site 255470003828 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 255470003829 arsenite S-adenosylmethyltransferase; Reviewed; Region: arsM; PRK11873 255470003830 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 255470003831 S-adenosylmethionine binding site [chemical binding]; other site 255470003832 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 255470003833 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 255470003834 Ligand Binding Site [chemical binding]; other site 255470003835 TilS substrate C-terminal domain; Region: TilS_C; smart00977 255470003836 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 255470003837 catalytic core [active] 255470003838 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 255470003839 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 255470003840 Domain of unknown function DUF21; Region: DUF21; pfam01595 255470003841 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 255470003842 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 255470003843 Transporter associated domain; Region: CorC_HlyC; pfam03471 255470003844 UGMP family protein; Validated; Region: PRK09604 255470003845 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 255470003846 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 255470003847 oligomerisation interface [polypeptide binding]; other site 255470003848 mobile loop; other site 255470003849 roof hairpin; other site 255470003850 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 255470003851 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 255470003852 ring oligomerisation interface [polypeptide binding]; other site 255470003853 ATP/Mg binding site [chemical binding]; other site 255470003854 stacking interactions; other site 255470003855 hinge regions; other site 255470003856 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 255470003857 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 255470003858 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 255470003859 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 255470003860 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 255470003861 Acylphosphatase; Region: Acylphosphatase; pfam00708 255470003862 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 255470003863 HypF finger; Region: zf-HYPF; pfam07503 255470003864 HypF finger; Region: zf-HYPF; pfam07503 255470003865 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 255470003866 HupF/HypC family; Region: HupF_HypC; pfam01455 255470003867 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 255470003868 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 255470003869 dimerization interface [polypeptide binding]; other site 255470003870 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 255470003871 ATP binding site [chemical binding]; other site 255470003872 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 255470003873 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 255470003874 glyceraldehyde-3-phosphate dehydrogenase B; Region: PLN02237 255470003875 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 255470003876 DNA binding residues [nucleotide binding] 255470003877 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 255470003878 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824 255470003879 putative hydrophobic ligand binding site [chemical binding]; other site 255470003880 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 255470003881 putative active site pocket [active] 255470003882 dimerization interface [polypeptide binding]; other site 255470003883 putative catalytic residue [active] 255470003884 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 255470003885 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 255470003886 5S rRNA interface [nucleotide binding]; other site 255470003887 CTC domain interface [polypeptide binding]; other site 255470003888 L16 interface [polypeptide binding]; other site 255470003889 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 255470003890 Amidohydrolase; Region: Amidohydro_2; pfam04909 255470003891 active site 255470003892 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 255470003893 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 255470003894 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 255470003895 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 255470003896 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 255470003897 active site 255470003898 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 255470003899 30S subunit binding site; other site 255470003900 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 255470003901 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 255470003902 DNA binding site [nucleotide binding] 255470003903 active site 255470003904 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 255470003905 hypothetical protein; Reviewed; Region: PRK00024 255470003906 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 255470003907 helix-hairpin-helix signature motif; other site 255470003908 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 255470003909 MPN+ (JAMM) motif; other site 255470003910 Zinc-binding site [ion binding]; other site 255470003911 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 255470003912 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 255470003913 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 255470003914 active site 255470003915 PHP Thumb interface [polypeptide binding]; other site 255470003916 metal binding site [ion binding]; metal-binding site 255470003917 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 255470003918 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 255470003919 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 255470003920 generic binding surface II; other site 255470003921 generic binding surface I; other site 255470003922 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 255470003923 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 255470003924 anthranilate synthase component I; Provisional; Region: PRK13565 255470003925 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 255470003926 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 255470003927 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 255470003928 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 255470003929 glutamine binding [chemical binding]; other site 255470003930 catalytic triad [active] 255470003931 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 255470003932 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 255470003933 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 255470003934 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 255470003935 active site 255470003936 ribulose/triose binding site [chemical binding]; other site 255470003937 phosphate binding site [ion binding]; other site 255470003938 substrate (anthranilate) binding pocket [chemical binding]; other site 255470003939 product (indole) binding pocket [chemical binding]; other site 255470003940 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 255470003941 active site 255470003942 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 255470003943 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 255470003944 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 255470003945 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 255470003946 pyridoxal 5'-phosphate binding site [chemical binding]; other site 255470003947 catalytic residue [active] 255470003948 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 255470003949 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 255470003950 substrate binding site [chemical binding]; other site 255470003951 active site 255470003952 catalytic residues [active] 255470003953 heterodimer interface [polypeptide binding]; other site 255470003954 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 255470003955 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 255470003956 reductive dehalogenase; Region: RDH; TIGR02486 255470003957 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 255470003958 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 255470003959 reductive dehalogenase; Region: RDH; TIGR02486 255470003960 Transcriptional regulators [Transcription]; Region: MarR; COG1846 255470003961 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 255470003962 Thymidylate synthase complementing protein; Region: Thy1; pfam02511 255470003963 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 255470003964 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 255470003965 Walker A/P-loop; other site 255470003966 ATP binding site [chemical binding]; other site 255470003967 Q-loop/lid; other site 255470003968 ABC transporter signature motif; other site 255470003969 Walker B; other site 255470003970 D-loop; other site 255470003971 H-loop/switch region; other site 255470003972 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 255470003973 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 255470003974 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 255470003975 Walker A/P-loop; other site 255470003976 ATP binding site [chemical binding]; other site 255470003977 Q-loop/lid; other site 255470003978 ABC transporter signature motif; other site 255470003979 Walker B; other site 255470003980 D-loop; other site 255470003981 H-loop/switch region; other site 255470003982 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 255470003983 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 255470003984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 255470003985 dimer interface [polypeptide binding]; other site 255470003986 conserved gate region; other site 255470003987 putative PBP binding loops; other site 255470003988 ABC-ATPase subunit interface; other site 255470003989 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 255470003990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 255470003991 dimer interface [polypeptide binding]; other site 255470003992 conserved gate region; other site 255470003993 putative PBP binding loops; other site 255470003994 ABC-ATPase subunit interface; other site 255470003995 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 255470003996 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 255470003997 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 255470003998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 255470003999 S-adenosylmethionine binding site [chemical binding]; other site 255470004000 Transcriptional regulators [Transcription]; Region: MarR; COG1846 255470004001 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 255470004002 dimerization interface [polypeptide binding]; other site 255470004003 putative Zn2+ binding site [ion binding]; other site 255470004004 putative DNA binding site [nucleotide binding]; other site 255470004005 camphor resistance protein CrcB; Provisional; Region: PRK14212 255470004006 Predicted transcriptional regulator [Transcription]; Region: COG1497 255470004007 MarR family; Region: MarR_2; pfam12802 255470004008 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 255470004009 Flavodoxins [Energy production and conversion]; Region: FldA; COG0716 255470004010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 255470004011 Major Facilitator Superfamily; Region: MFS_1; pfam07690 255470004012 putative substrate translocation pore; other site 255470004013 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 255470004014 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 255470004015 G1 box; other site 255470004016 GTP/Mg2+ binding site [chemical binding]; other site 255470004017 Switch I region; other site 255470004018 G2 box; other site 255470004019 G3 box; other site 255470004020 Switch II region; other site 255470004021 G4 box; other site 255470004022 G5 box; other site 255470004023 Nucleoside recognition; Region: Gate; pfam07670 255470004024 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 255470004025 Nucleoside recognition; Region: Gate; pfam07670 255470004026 FeoA domain; Region: FeoA; pfam04023 255470004027 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 255470004028 metal binding site 2 [ion binding]; metal-binding site 255470004029 putative DNA binding helix; other site 255470004030 metal binding site 1 [ion binding]; metal-binding site 255470004031 dimer interface [polypeptide binding]; other site 255470004032 structural Zn2+ binding site [ion binding]; other site 255470004033 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 255470004034 SmpB-tmRNA interface; other site 255470004035 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 255470004036 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 255470004037 catalytic residues [active] 255470004038 catalytic nucleophile [active] 255470004039 Recombinase; Region: Recombinase; pfam07508 255470004040 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 255470004041 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 255470004042 Resolvase, N terminal domain; Region: Resolvase; smart00857 255470004043 catalytic residues [active] 255470004044 catalytic nucleophile [active] 255470004045 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 255470004046 ParB-like nuclease domain; Region: ParB; smart00470 255470004047 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 255470004048 active site 255470004049 metal binding site [ion binding]; metal-binding site 255470004050 interdomain interaction site; other site 255470004051 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 255470004052 Transposase; Region: HTH_Tnp_1; cl17663 255470004053 putative transposase OrfB; Reviewed; Region: PHA02517 255470004054 HTH-like domain; Region: HTH_21; pfam13276 255470004055 Integrase core domain; Region: rve; pfam00665 255470004056 Integrase core domain; Region: rve_3; pfam13683 255470004057 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 255470004058 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 255470004059 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 255470004060 reductive dehalogenase; Region: RDH; TIGR02486 255470004061 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 255470004062 PAS domain; Region: PAS_9; pfam13426 255470004063 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 255470004064 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 255470004065 dimer interface [polypeptide binding]; other site 255470004066 phosphorylation site [posttranslational modification] 255470004067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 255470004068 ATP binding site [chemical binding]; other site 255470004069 Mg2+ binding site [ion binding]; other site 255470004070 G-X-G motif; other site 255470004071 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 255470004072 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 255470004073 active site 255470004074 phosphorylation site [posttranslational modification] 255470004075 intermolecular recognition site; other site 255470004076 dimerization interface [polypeptide binding]; other site 255470004077 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 255470004078 DNA binding site [nucleotide binding] 255470004079 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 255470004080 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 255470004081 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 255470004082 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 255470004083 reductive dehalogenase; Region: RDH; TIGR02486 255470004084 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 255470004085 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 255470004086 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470004087 putative active site [active] 255470004088 heme pocket [chemical binding]; other site 255470004089 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 255470004090 dimer interface [polypeptide binding]; other site 255470004091 phosphorylation site [posttranslational modification] 255470004092 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 255470004093 ATP binding site [chemical binding]; other site 255470004094 Mg2+ binding site [ion binding]; other site 255470004095 G-X-G motif; other site 255470004096 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 255470004097 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 255470004098 active site 255470004099 phosphorylation site [posttranslational modification] 255470004100 intermolecular recognition site; other site 255470004101 dimerization interface [polypeptide binding]; other site 255470004102 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 255470004103 DNA binding site [nucleotide binding] 255470004104 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 255470004105 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 255470004106 reductive dehalogenase; Region: RDH; TIGR02486 255470004107 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 255470004108 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 255470004109 Putative zinc- or iron-chelating domain; Region: CxxCxxCC; cl00497 255470004110 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 255470004111 reductive dehalogenase; Region: RDH; TIGR02486 255470004112 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 255470004113 Transcriptional regulators [Transcription]; Region: MarR; COG1846 255470004114 MarR family; Region: MarR_2; pfam12802 255470004115 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 255470004116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 255470004117 active site 255470004118 phosphorylation site [posttranslational modification] 255470004119 intermolecular recognition site; other site 255470004120 dimerization interface [polypeptide binding]; other site 255470004121 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 255470004122 DNA binding site [nucleotide binding] 255470004123 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 255470004124 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 255470004125 dimerization interface [polypeptide binding]; other site 255470004126 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 255470004127 dimer interface [polypeptide binding]; other site 255470004128 phosphorylation site [posttranslational modification] 255470004129 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 255470004130 ATP binding site [chemical binding]; other site 255470004131 Mg2+ binding site [ion binding]; other site 255470004132 G-X-G motif; other site 255470004133 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 255470004134 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 255470004135 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 255470004136 CT1975-like protein; Region: Cas_CT1975; pfam09344 255470004137 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 255470004138 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 255470004139 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 255470004140 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 255470004141 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 255470004142 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 255470004143 Double zinc ribbon; Region: DZR; pfam12773 255470004144 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 255470004145 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG4342 255470004146 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 255470004147 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 255470004148 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 255470004149 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 255470004150 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 255470004151 Walker A motif; other site 255470004152 ATP binding site [chemical binding]; other site 255470004153 Walker B motif; other site 255470004154 arginine finger; other site 255470004155 Predicted transcriptional regulator [Transcription]; Region: COG2378 255470004156 HTH domain; Region: HTH_11; cl17392 255470004157 WYL domain; Region: WYL; pfam13280 255470004158 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 255470004159 putative DNA binding site [nucleotide binding]; other site 255470004160 dimerization interface [polypeptide binding]; other site 255470004161 putative Zn2+ binding site [ion binding]; other site 255470004162 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 255470004163 active site 255470004164 NTP binding site [chemical binding]; other site 255470004165 metal binding triad [ion binding]; metal-binding site 255470004166 antibiotic binding site [chemical binding]; other site 255470004167 Transcriptional regulators [Transcription]; Region: MarR; COG1846 255470004168 MarR family; Region: MarR_2; pfam12802 255470004169 Penicillinase repressor; Region: Penicillinase_R; cl17580 255470004170 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 255470004171 reductive dehalogenase; Region: RDH; TIGR02486 255470004172 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 255470004173 Flagellin N-methylase; Region: FliB; pfam03692 255470004174 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 255470004175 Ligand Binding Site [chemical binding]; other site 255470004176 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 255470004177 reductive dehalogenase; Region: RDH; TIGR02486 255470004178 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 255470004179 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 255470004180 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 255470004181 reductive dehalogenase; Region: RDH; TIGR02486 255470004182 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 255470004183 PAS domain; Region: PAS; smart00091 255470004184 PAS domain; Region: PAS_9; pfam13426 255470004185 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470004186 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 255470004187 putative active site [active] 255470004188 heme pocket [chemical binding]; other site 255470004189 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 255470004190 dimer interface [polypeptide binding]; other site 255470004191 phosphorylation site [posttranslational modification] 255470004192 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 255470004193 ATP binding site [chemical binding]; other site 255470004194 Mg2+ binding site [ion binding]; other site 255470004195 G-X-G motif; other site 255470004196 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 255470004197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 255470004198 active site 255470004199 phosphorylation site [posttranslational modification] 255470004200 intermolecular recognition site; other site 255470004201 dimerization interface [polypeptide binding]; other site 255470004202 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 255470004203 DNA binding site [nucleotide binding] 255470004204 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 255470004205 reductive dehalogenase; Region: RDH; TIGR02486 255470004206 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 255470004207 PAS domain S-box; Region: sensory_box; TIGR00229 255470004208 PAS domain; Region: PAS; smart00091 255470004209 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 255470004210 Histidine kinase; Region: HisKA_3; pfam07730 255470004211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 255470004212 ATP binding site [chemical binding]; other site 255470004213 Mg2+ binding site [ion binding]; other site 255470004214 G-X-G motif; other site 255470004215 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 255470004216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 255470004217 active site 255470004218 phosphorylation site [posttranslational modification] 255470004219 intermolecular recognition site; other site 255470004220 dimerization interface [polypeptide binding]; other site 255470004221 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 255470004222 DNA binding residues [nucleotide binding] 255470004223 dimerization interface [polypeptide binding]; other site 255470004224 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 255470004225 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 255470004226 reductive dehalogenase; Region: RDH; TIGR02486 255470004227 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 255470004228 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 255470004229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 255470004230 active site 255470004231 intermolecular recognition site; other site 255470004232 dimerization interface [polypeptide binding]; other site 255470004233 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 255470004234 DNA binding site [nucleotide binding] 255470004235 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 255470004236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 255470004237 active site 255470004238 phosphorylation site [posttranslational modification] 255470004239 dimerization interface [polypeptide binding]; other site 255470004240 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 255470004241 DNA binding site [nucleotide binding] 255470004242 Transcriptional regulators [Transcription]; Region: MarR; COG1846 255470004243 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 255470004244 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 255470004245 Radical SAM superfamily; Region: Radical_SAM; pfam04055 255470004246 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 255470004247 FeS/SAM binding site; other site 255470004248 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 255470004249 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 255470004250 reductive dehalogenase; Region: RDH; TIGR02486 255470004251 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 255470004252 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 255470004253 reductive dehalogenase; Region: RDH; TIGR02486 255470004254 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 255470004255 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 255470004256 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 255470004257 active site 255470004258 phosphorylation site [posttranslational modification] 255470004259 intermolecular recognition site; other site 255470004260 dimerization interface [polypeptide binding]; other site 255470004261 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 255470004262 DNA binding site [nucleotide binding] 255470004263 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 255470004264 PAS domain; Region: PAS_9; pfam13426 255470004265 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470004266 putative active site [active] 255470004267 heme pocket [chemical binding]; other site 255470004268 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 255470004269 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 255470004270 dimer interface [polypeptide binding]; other site 255470004271 phosphorylation site [posttranslational modification] 255470004272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 255470004273 ATP binding site [chemical binding]; other site 255470004274 Mg2+ binding site [ion binding]; other site 255470004275 G-X-G motif; other site 255470004276 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 255470004277 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 255470004278 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 255470004279 DNA binding residues [nucleotide binding] 255470004280 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 255470004281 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 255470004282 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 255470004283 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 255470004284 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 255470004285 reductive dehalogenase; Region: RDH; TIGR02486 255470004286 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 255470004287 Transcriptional regulators [Transcription]; Region: MarR; COG1846 255470004288 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 255470004289 Integrase core domain; Region: rve; pfam00665 255470004290 Integrase core domain; Region: rve_3; pfam13683 255470004291 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 255470004292 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 255470004293 reductive dehalogenase; Region: RDH; TIGR02486 255470004294 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 255470004295 Transcriptional regulators [Transcription]; Region: MarR; COG1846 255470004296 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 255470004297 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 255470004298 reductive dehalogenase; Region: RDH; TIGR02486 255470004299 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 255470004300 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 255470004301 Ligand Binding Site [chemical binding]; other site 255470004302 Flagellin N-methylase; Region: FliB; pfam03692 255470004303 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 255470004304 reductive dehalogenase; Region: RDH; TIGR02486 255470004305 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 255470004306 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 255470004307 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 255470004308 Putative zinc- or iron-chelating domain; Region: CxxCxxCC; cl00497 255470004309 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 255470004310 reductive dehalogenase; Region: RDH; TIGR02486 255470004311 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 255470004312 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 255470004313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 255470004314 active site 255470004315 phosphorylation site [posttranslational modification] 255470004316 intermolecular recognition site; other site 255470004317 dimerization interface [polypeptide binding]; other site 255470004318 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 255470004319 DNA binding site [nucleotide binding] 255470004320 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470004321 PAS domain; Region: PAS_9; pfam13426 255470004322 putative active site [active] 255470004323 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470004324 putative active site [active] 255470004325 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 255470004326 heme pocket [chemical binding]; other site 255470004327 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 255470004328 dimer interface [polypeptide binding]; other site 255470004329 phosphorylation site [posttranslational modification] 255470004330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 255470004331 ATP binding site [chemical binding]; other site 255470004332 Mg2+ binding site [ion binding]; other site 255470004333 G-X-G motif; other site 255470004334 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 255470004335 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470004336 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 255470004337 putative active site [active] 255470004338 heme pocket [chemical binding]; other site 255470004339 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470004340 putative active site [active] 255470004341 heme pocket [chemical binding]; other site 255470004342 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470004343 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 255470004344 putative active site [active] 255470004345 heme pocket [chemical binding]; other site 255470004346 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470004347 histidine kinase; Provisional; Region: PRK13557 255470004348 putative active site [active] 255470004349 heme pocket [chemical binding]; other site 255470004350 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 255470004351 dimer interface [polypeptide binding]; other site 255470004352 phosphorylation site [posttranslational modification] 255470004353 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 255470004354 ATP binding site [chemical binding]; other site 255470004355 Mg2+ binding site [ion binding]; other site 255470004356 G-X-G motif; other site 255470004357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 255470004358 active site 255470004359 phosphorylation site [posttranslational modification] 255470004360 intermolecular recognition site; other site 255470004361 dimerization interface [polypeptide binding]; other site 255470004362 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 255470004363 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 255470004364 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 255470004365 reductive dehalogenase; Region: RDH; TIGR02486 255470004366 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 255470004367 Transcriptional regulators [Transcription]; Region: MarR; COG1846 255470004368 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 255470004369 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 255470004370 reductive dehalogenase; Region: RDH; TIGR02486 255470004371 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 255470004372 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 255470004373 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 255470004374 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470004375 PAS fold; Region: PAS_4; pfam08448 255470004376 putative active site [active] 255470004377 heme pocket [chemical binding]; other site 255470004378 PAS domain S-box; Region: sensory_box; TIGR00229 255470004379 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470004380 putative active site [active] 255470004381 heme pocket [chemical binding]; other site 255470004382 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 255470004383 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470004384 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 255470004385 putative active site [active] 255470004386 heme pocket [chemical binding]; other site 255470004387 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470004388 putative active site [active] 255470004389 heme pocket [chemical binding]; other site 255470004390 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 255470004391 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470004392 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 255470004393 putative active site [active] 255470004394 heme pocket [chemical binding]; other site 255470004395 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470004396 putative active site [active] 255470004397 heme pocket [chemical binding]; other site 255470004398 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 255470004399 dimer interface [polypeptide binding]; other site 255470004400 phosphorylation site [posttranslational modification] 255470004401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 255470004402 ATP binding site [chemical binding]; other site 255470004403 Mg2+ binding site [ion binding]; other site 255470004404 G-X-G motif; other site 255470004405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 255470004406 active site 255470004407 phosphorylation site [posttranslational modification] 255470004408 intermolecular recognition site; other site 255470004409 dimerization interface [polypeptide binding]; other site 255470004410 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 255470004411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 255470004412 active site 255470004413 phosphorylation site [posttranslational modification] 255470004414 intermolecular recognition site; other site 255470004415 dimerization interface [polypeptide binding]; other site 255470004416 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 255470004417 Zn2+ binding site [ion binding]; other site 255470004418 Mg2+ binding site [ion binding]; other site 255470004419 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 255470004420 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 255470004421 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 255470004422 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470004423 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 255470004424 putative active site [active] 255470004425 heme pocket [chemical binding]; other site 255470004426 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470004427 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 255470004428 putative active site [active] 255470004429 heme pocket [chemical binding]; other site 255470004430 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 255470004431 dimer interface [polypeptide binding]; other site 255470004432 phosphorylation site [posttranslational modification] 255470004433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 255470004434 ATP binding site [chemical binding]; other site 255470004435 Mg2+ binding site [ion binding]; other site 255470004436 G-X-G motif; other site 255470004437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 255470004438 active site 255470004439 phosphorylation site [posttranslational modification] 255470004440 intermolecular recognition site; other site 255470004441 dimerization interface [polypeptide binding]; other site 255470004442 DOMON-like domain of copper-dependent monooxygenases and related proteins; Region: DOMON_DOH; cd09631 255470004443 putative ligand binding site [chemical binding]; other site 255470004444 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 255470004445 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 255470004446 DNA binding residues [nucleotide binding] 255470004447 dimer interface [polypeptide binding]; other site 255470004448 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 255470004449 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 255470004450 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 255470004451 Walker A/P-loop; other site 255470004452 ATP binding site [chemical binding]; other site 255470004453 Q-loop/lid; other site 255470004454 ABC transporter signature motif; other site 255470004455 Walker B; other site 255470004456 D-loop; other site 255470004457 H-loop/switch region; other site 255470004458 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 255470004459 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 255470004460 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 255470004461 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 255470004462 Protein export membrane protein; Region: SecD_SecF; cl14618 255470004463 Transcriptional regulators [Transcription]; Region: MarR; COG1846 255470004464 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 255470004465 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 255470004466 reductive dehalogenase; Region: RDH; TIGR02486 255470004467 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 255470004468 Transcriptional regulators [Transcription]; Region: MarR; COG1846 255470004469 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 255470004470 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 255470004471 B12 binding site [chemical binding]; other site 255470004472 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 255470004473 Radical SAM superfamily; Region: Radical_SAM; pfam04055 255470004474 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 255470004475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 255470004476 Major Facilitator Superfamily; Region: MFS_1; pfam07690 255470004477 putative substrate translocation pore; other site 255470004478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 255470004479 Transcriptional regulators [Transcription]; Region: MarR; COG1846 255470004480 putative DNA binding site [nucleotide binding]; other site 255470004481 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 255470004482 putative Zn2+ binding site [ion binding]; other site 255470004483 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 255470004484 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 255470004485 reductive dehalogenase; Region: RDH; TIGR02486 255470004486 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 255470004487 Transcriptional regulators [Transcription]; Region: MarR; COG1846 255470004488 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 255470004489 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 255470004490 reductive dehalogenase; Region: RDH; TIGR02486 255470004491 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 255470004492 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 255470004493 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 255470004494 putative active site [active] 255470004495 heme pocket [chemical binding]; other site 255470004496 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 255470004497 dimer interface [polypeptide binding]; other site 255470004498 phosphorylation site [posttranslational modification] 255470004499 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 255470004500 ATP binding site [chemical binding]; other site 255470004501 Mg2+ binding site [ion binding]; other site 255470004502 G-X-G motif; other site 255470004503 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 255470004504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 255470004505 active site 255470004506 phosphorylation site [posttranslational modification] 255470004507 intermolecular recognition site; other site 255470004508 dimerization interface [polypeptide binding]; other site 255470004509 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 255470004510 DNA binding site [nucleotide binding] 255470004511 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 255470004512 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 255470004513 reductive dehalogenase; Region: RDH; TIGR02486 255470004514 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 255470004515 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 255470004516 Prephenate dehydratase; Region: PDT; pfam00800 255470004517 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 255470004518 putative L-Phe binding site [chemical binding]; other site 255470004519 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 255470004520 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 255470004521 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 255470004522 GatB domain; Region: GatB_Yqey; smart00845 255470004523 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 255470004524 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 255470004525 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 255470004526 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 255470004527 DNA binding residues [nucleotide binding] 255470004528 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 255470004529 Pectic acid lyase; Region: Pec_lyase; cl19904 255470004530 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 255470004531 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl19197 255470004532 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 255470004533 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl19174 255470004534 hydrogenase membrane subunit; Validated; Region: PRK08676 255470004535 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 255470004536 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 255470004537 NADH dehydrogenase; Region: NADHdh; cl00469 255470004538 hydrogenase membrane subunit; Validated; Region: PRK08667 255470004539 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 255470004540 methylglyoxal synthase; Validated; Region: mgsA; PRK05234 255470004541 substrate binding site [chemical binding]; other site 255470004542 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 255470004543 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 255470004544 Mechanosensitive ion channel; Region: MS_channel; pfam00924 255470004545 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 255470004546 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 255470004547 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 255470004548 putative NADP binding site [chemical binding]; other site 255470004549 putative substrate binding site [chemical binding]; other site 255470004550 active site 255470004551 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 255470004552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 255470004553 NAD(P) binding site [chemical binding]; other site 255470004554 active site 255470004555 peroxiredoxin; Provisional; Region: PRK13189 255470004556 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 255470004557 dimer interface [polypeptide binding]; other site 255470004558 decamer (pentamer of dimers) interface [polypeptide binding]; other site 255470004559 catalytic triad [active] 255470004560 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 255470004561 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 255470004562 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 255470004563 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 255470004564 Peptidase family M48; Region: Peptidase_M48; cl12018 255470004565 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 255470004566 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 255470004567 trimer interface [polypeptide binding]; other site 255470004568 active site 255470004569 substrate binding site [chemical binding]; other site 255470004570 CoA binding site [chemical binding]; other site 255470004571 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 255470004572 Quinolinate synthetase A protein; Region: NadA; pfam02445 255470004573 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 255470004574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 255470004575 S-adenosylmethionine binding site [chemical binding]; other site 255470004576 AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061 255470004577 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309 255470004578 dimerization interface [polypeptide binding]; other site 255470004579 putative ATP binding site [chemical binding]; other site 255470004580 Predicted transcriptional regulator [Transcription]; Region: COG1959 255470004581 Rrf2 family protein; Region: rrf2_super; TIGR00738 255470004582 ApbE family; Region: ApbE; pfam02424 255470004583 FMN-binding domain; Region: FMN_bind; pfam04205 255470004584 4Fe-4S binding domain; Region: Fer4_5; pfam12801 255470004585 FMN-binding domain; Region: FMN_bind; pfam04205 255470004586 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 255470004587 4Fe-4S binding domain; Region: Fer4_5; pfam12801 255470004588 4Fe-4S binding domain; Region: Fer4_5; pfam12801 255470004589 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 255470004590 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 255470004591 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 255470004592 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 255470004593 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 255470004594 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 255470004595 substrate binding pocket [chemical binding]; other site 255470004596 dimer interface [polypeptide binding]; other site 255470004597 inhibitor binding site; inhibition site 255470004598 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 255470004599 catalytic center binding site [active] 255470004600 ATP binding site [chemical binding]; other site 255470004601 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 255470004602 active site 255470004603 recombinase A; Provisional; Region: recA; PRK09354 255470004604 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 255470004605 hexamer interface [polypeptide binding]; other site 255470004606 Walker A motif; other site 255470004607 ATP binding site [chemical binding]; other site 255470004608 Walker B motif; other site 255470004609 recombination regulator RecX; Reviewed; Region: recX; PRK00117 255470004610 ribonuclease Y; Region: RNase_Y; TIGR03319 255470004611 KH domain; Region: KH_1; pfam00013 255470004612 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 255470004613 Zn2+ binding site [ion binding]; other site 255470004614 Mg2+ binding site [ion binding]; other site 255470004615 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 255470004616 putative active site [active] 255470004617 metal binding site [ion binding]; metal-binding site 255470004618 homodimer binding site [polypeptide binding]; other site 255470004619 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 255470004620 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 255470004621 active site 255470004622 membrane protein; Provisional; Region: PRK14417 255470004623 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 255470004624 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 255470004625 minor groove reading motif; other site 255470004626 helix-hairpin-helix signature motif; other site 255470004627 substrate binding pocket [chemical binding]; other site 255470004628 active site 255470004629 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 255470004630 homodimer interaction site [polypeptide binding]; other site 255470004631 cofactor binding site; other site 255470004632 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 255470004633 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 255470004634 active site 255470004635 catalytic residues [active] 255470004636 metal binding site [ion binding]; metal-binding site 255470004637 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 255470004638 nucleotide binding site/active site [active] 255470004639 HIT family signature motif; other site 255470004640 catalytic residue [active] 255470004641 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 255470004642 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 255470004643 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 255470004644 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 255470004645 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 255470004646 Walker A/P-loop; other site 255470004647 ATP binding site [chemical binding]; other site 255470004648 Q-loop/lid; other site 255470004649 ABC transporter signature motif; other site 255470004650 Walker B; other site 255470004651 D-loop; other site 255470004652 H-loop/switch region; other site 255470004653 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 255470004654 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 255470004655 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 255470004656 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 255470004657 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 255470004658 trimer interface [polypeptide binding]; other site 255470004659 putative Zn binding site [ion binding]; other site 255470004660 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 255470004661 non-heme iron binding site [ion binding]; other site 255470004662 dimer interface [polypeptide binding]; other site 255470004663 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 255470004664 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 255470004665 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935 255470004666 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 255470004667 putative cation:proton antiport protein; Provisional; Region: PRK10669 255470004668 TrkA-N domain; Region: TrkA_N; pfam02254 255470004669 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 255470004670 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 255470004671 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 255470004672 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 255470004673 FeS/SAM binding site; other site 255470004674 DNA gyrase subunit A; Validated; Region: PRK05560 255470004675 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 255470004676 CAP-like domain; other site 255470004677 active site 255470004678 primary dimer interface [polypeptide binding]; other site 255470004679 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 255470004680 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 255470004681 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 255470004682 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 255470004683 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 255470004684 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 255470004685 binding surface 255470004686 Tetratricopeptide repeat; Region: TPR_16; pfam13432 255470004687 TPR motif; other site 255470004688 NifU-like domain; Region: NifU; cl00484 255470004689 aspartate kinase; Reviewed; Region: PRK06635 255470004690 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 255470004691 putative nucleotide binding site [chemical binding]; other site 255470004692 putative catalytic residues [active] 255470004693 putative Mg ion binding site [ion binding]; other site 255470004694 putative aspartate binding site [chemical binding]; other site 255470004695 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 255470004696 putative allosteric regulatory site; other site 255470004697 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 255470004698 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 255470004699 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 255470004700 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 255470004701 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 255470004702 homodimer interface [polypeptide binding]; other site 255470004703 metal binding site [ion binding]; metal-binding site 255470004704 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 255470004705 homodimer interface [polypeptide binding]; other site 255470004706 active site 255470004707 putative chemical substrate binding site [chemical binding]; other site 255470004708 metal binding site [ion binding]; metal-binding site 255470004709 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 255470004710 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 255470004711 LexA repressor; Validated; Region: PRK00215 255470004712 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 255470004713 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 255470004714 Catalytic site [active] 255470004715 L-fuculose phosphate aldolase; Provisional; Region: PRK08660 255470004716 intersubunit interface [polypeptide binding]; other site 255470004717 active site 255470004718 Zn2+ binding site [ion binding]; other site 255470004719 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 255470004720 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 255470004721 putative active site [active] 255470004722 substrate binding site [chemical binding]; other site 255470004723 putative cosubstrate binding site; other site 255470004724 catalytic site [active] 255470004725 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 255470004726 substrate binding site [chemical binding]; other site