-- dump date 20140619_055927 -- class Genbank::misc_feature -- table misc_feature_note -- id note 633145000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 633145000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 633145000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633145000004 Walker A motif; other site 633145000005 ATP binding site [chemical binding]; other site 633145000006 arginine finger; other site 633145000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 633145000008 DnaA box-binding interface [nucleotide binding]; other site 633145000009 GTPase CgtA; Reviewed; Region: obgE; PRK12297 633145000010 GTP1/OBG; Region: GTP1_OBG; pfam01018 633145000011 Obg GTPase; Region: Obg; cd01898 633145000012 G1 box; other site 633145000013 GTP/Mg2+ binding site [chemical binding]; other site 633145000014 Switch I region; other site 633145000015 G2 box; other site 633145000016 G3 box; other site 633145000017 Switch II region; other site 633145000018 G4 box; other site 633145000019 G5 box; other site 633145000020 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 633145000021 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 633145000022 active site 633145000023 (T/H)XGH motif; other site 633145000024 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 633145000025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633145000026 ATP binding site [chemical binding]; other site 633145000027 Mg2+ binding site [ion binding]; other site 633145000028 G-X-G motif; other site 633145000029 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 633145000030 anchoring element; other site 633145000031 dimer interface [polypeptide binding]; other site 633145000032 ATP binding site [chemical binding]; other site 633145000033 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 633145000034 active site 633145000035 putative metal-binding site [ion binding]; other site 633145000036 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 633145000037 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 633145000038 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 633145000039 Zn2+ binding site [ion binding]; other site 633145000040 Mg2+ binding site [ion binding]; other site 633145000041 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 633145000042 synthetase active site [active] 633145000043 NTP binding site [chemical binding]; other site 633145000044 metal binding site [ion binding]; metal-binding site 633145000045 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 633145000046 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 633145000047 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 633145000048 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 633145000049 dimer interface [polypeptide binding]; other site 633145000050 motif 1; other site 633145000051 active site 633145000052 motif 2; other site 633145000053 motif 3; other site 633145000054 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 633145000055 anticodon binding site; other site 633145000056 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 633145000057 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633145000058 membrane protein; Provisional; Region: PRK14416 633145000059 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 633145000060 homodimer interface [polypeptide binding]; other site 633145000061 substrate-cofactor binding pocket; other site 633145000062 catalytic residue [active] 633145000063 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 633145000064 active site 633145000065 DNA polymerase IV; Validated; Region: PRK02406 633145000066 DNA binding site [nucleotide binding] 633145000067 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 633145000068 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 633145000069 active site 633145000070 dimer interface [polypeptide binding]; other site 633145000071 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 633145000072 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 633145000073 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 633145000074 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 633145000075 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 633145000076 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 633145000077 metal binding site 2 [ion binding]; metal-binding site 633145000078 putative DNA binding helix; other site 633145000079 metal binding site 1 [ion binding]; metal-binding site 633145000080 dimer interface [polypeptide binding]; other site 633145000081 structural Zn2+ binding site [ion binding]; other site 633145000082 Septum formation initiator; Region: DivIC; cl17659 633145000083 Pleckstrin homology-like domain; Region: PH-like; cl17171 633145000084 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 633145000085 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 633145000086 Competence protein; Region: Competence; pfam03772 633145000087 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 633145000088 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 633145000089 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 633145000090 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 633145000091 TrkA-N domain; Region: TrkA_N; pfam02254 633145000092 TrkA-C domain; Region: TrkA_C; pfam02080 633145000093 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 633145000094 TrkA-N domain; Region: TrkA_N; pfam02254 633145000095 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 633145000096 Ligand Binding Site [chemical binding]; other site 633145000097 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 633145000098 Cation transport protein; Region: TrkH; cl17365 633145000099 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 633145000100 TrkA-N domain; Region: TrkA_N; pfam02254 633145000101 TrkA-C domain; Region: TrkA_C; pfam02080 633145000102 TrkA-N domain; Region: TrkA_N; pfam02254 633145000103 TrkA-C domain; Region: TrkA_C; pfam02080 633145000104 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 633145000105 TIGR00153 family protein; Region: TIGR00153 633145000106 Phosphate transporter family; Region: PHO4; pfam01384 633145000107 Guanylate kinase; Region: Guanylate_kin; pfam00625 633145000108 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 633145000109 catalytic site [active] 633145000110 G-X2-G-X-G-K; other site 633145000111 hypothetical protein; Provisional; Region: PRK04323 633145000112 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 633145000113 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 633145000114 FAD binding pocket [chemical binding]; other site 633145000115 FAD binding motif [chemical binding]; other site 633145000116 phosphate binding motif [ion binding]; other site 633145000117 beta-alpha-beta structure motif; other site 633145000118 NAD binding pocket [chemical binding]; other site 633145000119 Iron coordination center [ion binding]; other site 633145000120 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 633145000121 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 633145000122 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 633145000123 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 633145000124 Methyltransferase domain; Region: Methyltransf_31; pfam13847 633145000125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633145000126 S-adenosylmethionine binding site [chemical binding]; other site 633145000127 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 633145000128 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 633145000129 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 633145000130 GTP-binding protein YchF; Reviewed; Region: PRK09601 633145000131 YchF GTPase; Region: YchF; cd01900 633145000132 G1 box; other site 633145000133 GTP/Mg2+ binding site [chemical binding]; other site 633145000134 Switch I region; other site 633145000135 G2 box; other site 633145000136 Switch II region; other site 633145000137 G3 box; other site 633145000138 G4 box; other site 633145000139 G5 box; other site 633145000140 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 633145000141 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912 633145000142 DNA polymerase III, delta subunit; Region: holA; TIGR01128 633145000143 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 633145000144 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 633145000145 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 633145000146 nucleotide binding site [chemical binding]; other site 633145000147 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 633145000148 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 633145000149 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 633145000150 motif 1; other site 633145000151 active site 633145000152 motif 2; other site 633145000153 motif 3; other site 633145000154 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 633145000155 FlxA-like protein; Region: FlxA; pfam14282 633145000156 DHHA1 domain; Region: DHHA1; pfam02272 633145000157 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 633145000158 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 633145000159 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 633145000160 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 633145000161 active site 633145000162 NAD binding site [chemical binding]; other site 633145000163 metal binding site [ion binding]; metal-binding site 633145000164 Clp protease ATP binding subunit; Region: clpC; CHL00095 633145000165 Clp amino terminal domain; Region: Clp_N; pfam02861 633145000166 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633145000167 Walker A motif; other site 633145000168 ATP binding site [chemical binding]; other site 633145000169 Walker B motif; other site 633145000170 arginine finger; other site 633145000171 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633145000172 Walker A motif; other site 633145000173 ATP binding site [chemical binding]; other site 633145000174 Walker B motif; other site 633145000175 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 633145000176 DNA repair protein RadA; Provisional; Region: PRK11823 633145000177 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 633145000178 Walker A motif/ATP binding site; other site 633145000179 ATP binding site [chemical binding]; other site 633145000180 Walker B motif; other site 633145000181 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 633145000182 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 633145000183 substrate binding site; other site 633145000184 dimer interface; other site 633145000185 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 633145000186 homotrimer interaction site [polypeptide binding]; other site 633145000187 zinc binding site [ion binding]; other site 633145000188 CDP-binding sites; other site 633145000189 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 633145000190 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 633145000191 active site 633145000192 HIGH motif; other site 633145000193 KMSKS motif; other site 633145000194 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 633145000195 tRNA binding surface [nucleotide binding]; other site 633145000196 anticodon binding site; other site 633145000197 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 633145000198 Predicted ATP-dependent Lon-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG4930 633145000199 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 633145000200 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 633145000201 PglZ domain; Region: PglZ; pfam08665 633145000202 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 633145000203 DNA methylase; Region: N6_N4_Mtase; cl17433 633145000204 DNA methylase; Region: N6_N4_Mtase; cl17433 633145000205 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 633145000206 DNA binding domain, excisionase family; Region: excise; TIGR01764 633145000207 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 633145000208 beta-clamp/clamp loader binding surface; other site 633145000209 beta-clamp/translesion DNA polymerase binding surface; other site 633145000210 Mitochondria Localisation Sequence; Region: AIF-MLS; pfam14962 633145000211 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 633145000212 GIY-YIG motif/motif A; other site 633145000213 putative active site [active] 633145000214 putative metal binding site [ion binding]; other site 633145000215 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 633145000216 Domain of unknown function (DUF955); Region: DUF955; cl01076 633145000217 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 633145000218 active site 633145000219 DNA binding site [nucleotide binding] 633145000220 Int/Topo IB signature motif; other site 633145000221 hypothetical protein; Region: PHA00650 633145000222 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 633145000223 Subtilase family; Region: Peptidase_S8; pfam00082 633145000224 active site 633145000225 catalytic residues [active] 633145000226 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 633145000227 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 633145000228 DNA-binding site [nucleotide binding]; DNA binding site 633145000229 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633145000230 Walker B motif; other site 633145000231 arginine finger; other site 633145000232 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 633145000233 HSP70 interaction site [polypeptide binding]; other site 633145000234 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 633145000235 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 633145000236 active site 633145000237 metal binding site [ion binding]; metal-binding site 633145000238 interdomain interaction site; other site 633145000239 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 633145000240 sequence-specific DNA binding site [nucleotide binding]; other site 633145000241 salt bridge; other site 633145000242 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 633145000243 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 633145000244 non-specific DNA binding site [nucleotide binding]; other site 633145000245 salt bridge; other site 633145000246 sequence-specific DNA binding site [nucleotide binding]; other site 633145000247 Domain of unknown function (DUF955); Region: DUF955; cl01076 633145000248 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 633145000249 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 633145000250 catalytic residues [active] 633145000251 catalytic nucleophile [active] 633145000252 Recombinase; Region: Recombinase; pfam07508 633145000253 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 633145000254 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 633145000255 non-specific DNA binding site [nucleotide binding]; other site 633145000256 salt bridge; other site 633145000257 sequence-specific DNA binding site [nucleotide binding]; other site 633145000258 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 633145000259 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 633145000260 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 633145000261 reductive dehalogenase; Region: RDH; TIGR02486 633145000262 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 633145000263 Transposase; Region: HTH_Tnp_1; cl17663 633145000264 putative transposase OrfB; Reviewed; Region: PHA02517 633145000265 HTH-like domain; Region: HTH_21; pfam13276 633145000266 Integrase core domain; Region: rve; pfam00665 633145000267 Integrase core domain; Region: rve_3; pfam13683 633145000268 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 633145000269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633145000270 active site 633145000271 phosphorylation site [posttranslational modification] 633145000272 intermolecular recognition site; other site 633145000273 dimerization interface [polypeptide binding]; other site 633145000274 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 633145000275 DNA binding residues [nucleotide binding] 633145000276 dimerization interface [polypeptide binding]; other site 633145000277 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 633145000278 dinuclear metal binding motif [ion binding]; other site 633145000279 NTPase; Region: NTPase_1; cl17478 633145000280 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 633145000281 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 633145000282 GTP binding site; other site 633145000283 tetrathionate reductase subunit A; Provisional; Region: PRK14991 633145000284 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 633145000285 molybdopterin cofactor binding site; other site 633145000286 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 633145000287 putative molybdopterin cofactor binding site; other site 633145000288 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 633145000289 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 633145000290 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 633145000291 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 633145000292 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 633145000293 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 633145000294 Walker A motif; other site 633145000295 EDD domain protein, DegV family; Region: DegV; TIGR00762 633145000296 E3 Ubiquitin ligase; Region: GIDE; pfam12483 633145000297 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 633145000298 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 633145000299 putative catalytic site [active] 633145000300 putative metal binding site [ion binding]; other site 633145000301 putative phosphate binding site [ion binding]; other site 633145000302 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 633145000303 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 633145000304 putative substrate-binding site; other site 633145000305 nickel binding site [ion binding]; other site 633145000306 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 633145000307 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 633145000308 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 633145000309 NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720 633145000310 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 633145000311 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 633145000312 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 633145000313 ABC-2 type transporter; Region: ABC2_membrane; cl17235 633145000314 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 633145000315 Acyltransferase family; Region: Acyl_transf_3; cl19154 633145000316 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 633145000317 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633145000318 Walker A/P-loop; other site 633145000319 ATP binding site [chemical binding]; other site 633145000320 Q-loop/lid; other site 633145000321 ABC transporter signature motif; other site 633145000322 Walker B; other site 633145000323 D-loop; other site 633145000324 H-loop/switch region; other site 633145000325 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 633145000326 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 633145000327 DJ-1 family protein; Region: not_thiJ; TIGR01383 633145000328 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 633145000329 conserved cys residue [active] 633145000330 pyruvate carboxylase subunit B; Validated; Region: PRK09282 633145000331 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 633145000332 active site 633145000333 catalytic residues [active] 633145000334 metal binding site [ion binding]; metal-binding site 633145000335 homodimer binding site [polypeptide binding]; other site 633145000336 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 633145000337 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 633145000338 carboxyltransferase (CT) interaction site; other site 633145000339 biotinylation site [posttranslational modification]; other site 633145000340 pyruvate carboxylase subunit A; Validated; Region: PRK08654 633145000341 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 633145000342 ATP-grasp domain; Region: ATP-grasp_4; cl17255 633145000343 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 633145000344 2TM domain; Region: 2TM; pfam13239 633145000345 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 633145000346 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 633145000347 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 633145000348 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 633145000349 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 633145000350 4Fe-4S binding domain; Region: Fer4; pfam00037 633145000351 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 633145000352 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 633145000353 NAD(P) binding site [chemical binding]; other site 633145000354 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 633145000355 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 633145000356 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 633145000357 GAF domain; Region: GAF_2; pfam13185 633145000358 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145000359 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 633145000360 putative active site [active] 633145000361 heme pocket [chemical binding]; other site 633145000362 PAS domain; Region: PAS; smart00091 633145000363 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 633145000364 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145000365 putative active site [active] 633145000366 heme pocket [chemical binding]; other site 633145000367 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 633145000368 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145000369 putative active site [active] 633145000370 heme pocket [chemical binding]; other site 633145000371 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 633145000372 dimer interface [polypeptide binding]; other site 633145000373 phosphorylation site [posttranslational modification] 633145000374 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633145000375 ATP binding site [chemical binding]; other site 633145000376 Mg2+ binding site [ion binding]; other site 633145000377 G-X-G motif; other site 633145000378 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 633145000379 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 633145000380 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 633145000381 catalytic triad [active] 633145000382 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 633145000383 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 633145000384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633145000385 active site 633145000386 phosphorylation site [posttranslational modification] 633145000387 intermolecular recognition site; other site 633145000388 dimerization interface [polypeptide binding]; other site 633145000389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633145000390 active site 633145000391 phosphorylation site [posttranslational modification] 633145000392 intermolecular recognition site; other site 633145000393 dimerization interface [polypeptide binding]; other site 633145000394 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 633145000395 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 633145000396 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124 633145000397 DNA polymerase, archaeal type II, large subunit; Region: polC; TIGR00354 633145000398 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 633145000399 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 633145000400 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 633145000401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633145000402 active site 633145000403 phosphorylation site [posttranslational modification] 633145000404 intermolecular recognition site; other site 633145000405 dimerization interface [polypeptide binding]; other site 633145000406 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 633145000407 DNA binding site [nucleotide binding] 633145000408 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 633145000409 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 633145000410 dimerization interface [polypeptide binding]; other site 633145000411 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145000412 putative active site [active] 633145000413 heme pocket [chemical binding]; other site 633145000414 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 633145000415 dimer interface [polypeptide binding]; other site 633145000416 phosphorylation site [posttranslational modification] 633145000417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633145000418 ATP binding site [chemical binding]; other site 633145000419 Mg2+ binding site [ion binding]; other site 633145000420 G-X-G motif; other site 633145000421 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 633145000422 active site 633145000423 dimer interfaces [polypeptide binding]; other site 633145000424 catalytic residues [active] 633145000425 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 633145000426 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 633145000427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633145000428 dimer interface [polypeptide binding]; other site 633145000429 conserved gate region; other site 633145000430 putative PBP binding loops; other site 633145000431 ABC-ATPase subunit interface; other site 633145000432 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 633145000433 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633145000434 dimer interface [polypeptide binding]; other site 633145000435 conserved gate region; other site 633145000436 putative PBP binding loops; other site 633145000437 ABC-ATPase subunit interface; other site 633145000438 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14249 633145000439 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 633145000440 Walker A/P-loop; other site 633145000441 ATP binding site [chemical binding]; other site 633145000442 Q-loop/lid; other site 633145000443 ABC transporter signature motif; other site 633145000444 Walker B; other site 633145000445 D-loop; other site 633145000446 H-loop/switch region; other site 633145000447 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 633145000448 PhoU domain; Region: PhoU; pfam01895 633145000449 PhoU domain; Region: PhoU; pfam01895 633145000450 Low molecular weight phosphatase family; Region: LMWPc; cd00115 633145000451 active site 633145000452 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 633145000453 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 633145000454 putative dimer interface [polypeptide binding]; other site 633145000455 [2Fe-2S] cluster binding site [ion binding]; other site 633145000456 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 633145000457 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 633145000458 SLBB domain; Region: SLBB; pfam10531 633145000459 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 633145000460 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 633145000461 catalytic loop [active] 633145000462 iron binding site [ion binding]; other site 633145000463 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 633145000464 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 633145000465 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 633145000466 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 633145000467 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; smart00902 633145000468 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 633145000469 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 633145000470 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 633145000471 Protein of unknown function DUF45; Region: DUF45; pfam01863 633145000472 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 633145000473 EamA-like transporter family; Region: EamA; pfam00892 633145000474 EamA-like transporter family; Region: EamA; pfam00892 633145000475 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 633145000476 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 633145000477 tetramer interface [polypeptide binding]; other site 633145000478 pyridoxal 5'-phosphate binding site [chemical binding]; other site 633145000479 catalytic residue [active] 633145000480 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 633145000481 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 633145000482 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 633145000483 catalytic residues [active] 633145000484 catalytic nucleophile [active] 633145000485 Recombinase; Region: Recombinase; pfam07508 633145000486 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 633145000487 Domain of unknown function (DUF955); Region: DUF955; cl01076 633145000488 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 633145000489 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 633145000490 non-specific DNA binding site [nucleotide binding]; other site 633145000491 salt bridge; other site 633145000492 sequence-specific DNA binding site [nucleotide binding]; other site 633145000493 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 633145000494 non-specific DNA binding site [nucleotide binding]; other site 633145000495 salt bridge; other site 633145000496 sequence-specific DNA binding site [nucleotide binding]; other site 633145000497 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 633145000498 active site 633145000499 metal binding site [ion binding]; metal-binding site 633145000500 interdomain interaction site; other site 633145000501 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 633145000502 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 633145000503 HSP70 interaction site [polypeptide binding]; other site 633145000504 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633145000505 Walker B motif; other site 633145000506 arginine finger; other site 633145000507 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 633145000508 DNA-binding site [nucleotide binding]; DNA binding site 633145000509 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 633145000510 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 633145000511 Subtilase family; Region: Peptidase_S8; pfam00082 633145000512 active site 633145000513 catalytic residues [active] 633145000514 hypothetical protein; Region: PHA00650 633145000515 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 633145000516 active site 633145000517 DNA binding site [nucleotide binding] 633145000518 Int/Topo IB signature motif; other site 633145000519 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 633145000520 Domain of unknown function (DUF955); Region: DUF955; cl01076 633145000521 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 633145000522 GIY-YIG motif/motif A; other site 633145000523 putative active site [active] 633145000524 putative metal binding site [ion binding]; other site 633145000525 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 633145000526 beta-clamp/clamp loader binding surface; other site 633145000527 beta-clamp/translesion DNA polymerase binding surface; other site 633145000528 Mitochondria Localisation Sequence; Region: AIF-MLS; pfam14962 633145000529 DNA binding domain, excisionase family; Region: excise; TIGR01764 633145000530 N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178 633145000531 PLD-like domain; Region: PLDc_2; pfam13091 633145000532 putative homodimer interface [polypeptide binding]; other site 633145000533 putative active site [active] 633145000534 catalytic site [active] 633145000535 DEAD-like helicases superfamily; Region: DEXDc; smart00487 633145000536 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633145000537 ATP binding site [chemical binding]; other site 633145000538 putative Mg++ binding site [ion binding]; other site 633145000539 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633145000540 nucleotide binding region [chemical binding]; other site 633145000541 ATP-binding site [chemical binding]; other site 633145000542 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 633145000543 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 633145000544 AAA domain; Region: AAA_13; pfam13166 633145000545 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 633145000546 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 633145000547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633145000548 active site 633145000549 phosphorylation site [posttranslational modification] 633145000550 intermolecular recognition site; other site 633145000551 dimerization interface [polypeptide binding]; other site 633145000552 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 633145000553 DNA binding site [nucleotide binding] 633145000554 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 633145000555 dimer interface [polypeptide binding]; other site 633145000556 phosphorylation site [posttranslational modification] 633145000557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633145000558 ATP binding site [chemical binding]; other site 633145000559 Mg2+ binding site [ion binding]; other site 633145000560 G-X-G motif; other site 633145000561 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 633145000562 reductive dehalogenase; Region: RDH; TIGR02486 633145000563 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 633145000564 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 633145000565 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 633145000566 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 633145000567 ATP binding site [chemical binding]; other site 633145000568 Mg++ binding site [ion binding]; other site 633145000569 motif III; other site 633145000570 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633145000571 nucleotide binding region [chemical binding]; other site 633145000572 ATP-binding site [chemical binding]; other site 633145000573 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 633145000574 Protein involved in formate dehydrogenase formation; Region: FdhE; cl19312 633145000575 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 633145000576 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 633145000577 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 633145000578 [4Fe-4S] binding site [ion binding]; other site 633145000579 molybdopterin cofactor binding site; other site 633145000580 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 633145000581 molybdopterin cofactor binding site; other site 633145000582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633145000583 S-adenosylmethionine binding site [chemical binding]; other site 633145000584 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 633145000585 active site 633145000586 (T/H)XGH motif; other site 633145000587 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 633145000588 Colicin V production protein; Region: Colicin_V; pfam02674 633145000589 pyrroline-5-carboxylate reductase; Region: PLN02688 633145000590 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 633145000591 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 633145000592 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 633145000593 active site 633145000594 HIGH motif; other site 633145000595 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 633145000596 KMSKS motif; other site 633145000597 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 633145000598 tRNA binding surface [nucleotide binding]; other site 633145000599 HI0933-like protein; Region: HI0933_like; pfam03486 633145000600 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 633145000601 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 633145000602 GrpB protein; Region: GrpB; pfam04229 633145000603 Protein of unknown function (DUF2769); Region: DUF2769; pfam10967 633145000604 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 633145000605 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 633145000606 catalytic residues [active] 633145000607 Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977 633145000608 Rubredoxin [Energy production and conversion]; Region: COG1773 633145000609 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 633145000610 iron binding site [ion binding]; other site 633145000611 Protein of unknown function (DUF1616); Region: DUF1616; pfam07760 633145000612 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 633145000613 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 633145000614 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 633145000615 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 633145000616 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 633145000617 active site 633145000618 catalytic tetrad [active] 633145000619 Predicted DNA-binding proteins [General function prediction only]; Region: COG1342 633145000620 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 633145000621 DNA binding residues [nucleotide binding] 633145000622 HEAT repeats; Region: HEAT_2; pfam13646 633145000623 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 633145000624 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 633145000625 FeS/SAM binding site; other site 633145000626 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 633145000627 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 633145000628 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 633145000629 Coenzyme A binding pocket [chemical binding]; other site 633145000630 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 633145000631 reactive center loop; other site 633145000632 Haemolysin-III related; Region: HlyIII; cl03831 633145000633 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 633145000634 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 633145000635 ABC transporter; Region: ABC_tran_2; pfam12848 633145000636 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 633145000637 flavoprotein, HI0933 family; Region: TIGR00275 633145000638 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 633145000639 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 633145000640 Hydrogenase expression/synthesis hypA family; Region: HypA; cl19201 633145000641 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 633145000642 Double zinc ribbon; Region: DZR; pfam12773 633145000643 TM2 domain; Region: TM2; pfam05154 633145000644 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 633145000645 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 633145000646 active site 633145000647 nucleophile elbow; other site 633145000648 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 633145000649 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 633145000650 HerA helicase [Replication, recombination, and repair]; Region: COG0433 633145000651 HAS barrel domain; Region: HAS-barrel; pfam09378 633145000652 Domain of unknown function DUF87; Region: DUF87; pfam01935 633145000653 NurA nuclease; Region: NurA; smart00933 633145000654 LysE type translocator; Region: LysE; cl00565 633145000655 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 633145000656 active site 633145000657 Zn binding site [ion binding]; other site 633145000658 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 633145000659 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 633145000660 Protein export membrane protein; Region: SecD_SecF; pfam02355 633145000661 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 633145000662 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 633145000663 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 633145000664 metal binding triad [ion binding]; metal-binding site 633145000665 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 633145000666 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 633145000667 Zn2+ binding site [ion binding]; other site 633145000668 Mg2+ binding site [ion binding]; other site 633145000669 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 633145000670 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 633145000671 non-specific DNA binding site [nucleotide binding]; other site 633145000672 salt bridge; other site 633145000673 sequence-specific DNA binding site [nucleotide binding]; other site 633145000674 primosome assembly protein PriA; Validated; Region: PRK05580 633145000675 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633145000676 ATP binding site [chemical binding]; other site 633145000677 putative Mg++ binding site [ion binding]; other site 633145000678 Trm112p-like protein; Region: Trm112p; cl01066 633145000679 helicase superfamily c-terminal domain; Region: HELICc; smart00490 633145000680 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 633145000681 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 633145000682 cell division protein MraZ; Reviewed; Region: PRK00326 633145000683 MraZ protein; Region: MraZ; pfam02381 633145000684 MraZ protein; Region: MraZ; pfam02381 633145000685 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 633145000686 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 633145000687 Cell division protein FtsA; Region: FtsA; smart00842 633145000688 Cell division protein FtsA; Region: FtsA; pfam14450 633145000689 cell division protein FtsZ; Validated; Region: PRK09330 633145000690 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 633145000691 nucleotide binding site [chemical binding]; other site 633145000692 SulA interaction site; other site 633145000693 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 633145000694 ATP cone domain; Region: ATP-cone; pfam03477 633145000695 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 633145000696 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 633145000697 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 633145000698 active site 633145000699 dimer interface [polypeptide binding]; other site 633145000700 effector binding site; other site 633145000701 TSCPD domain; Region: TSCPD; pfam12637 633145000702 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 633145000703 Uncharacterized conserved protein [Function unknown]; Region: COG1432 633145000704 LabA_like proteins; Region: LabA_like; cd06167 633145000705 putative metal binding site [ion binding]; other site 633145000706 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 633145000707 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 633145000708 FeS/SAM binding site; other site 633145000709 Yqey-like protein; Region: YqeY; pfam09424 633145000710 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 633145000711 CARDB; Region: CARDB; pfam07705 633145000712 Uncharacterized conserved protein [Function unknown]; Region: COG5484 633145000713 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 633145000714 Putative zinc ribbon domain; Region: DUF164; pfam02591 633145000715 RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Region: RNase_HI_like; cd09279 633145000716 RNA/DNA hybrid binding site [nucleotide binding]; other site 633145000717 active site 633145000718 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 633145000719 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 633145000720 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 633145000721 protein binding site [polypeptide binding]; other site 633145000722 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 633145000723 Catalytic dyad [active] 633145000724 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 633145000725 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 633145000726 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 633145000727 dimer interface [polypeptide binding]; other site 633145000728 motif 1; other site 633145000729 active site 633145000730 motif 2; other site 633145000731 motif 3; other site 633145000732 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 633145000733 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 633145000734 putative tRNA-binding site [nucleotide binding]; other site 633145000735 B3/4 domain; Region: B3_4; pfam03483 633145000736 tRNA synthetase B5 domain; Region: B5; pfam03484 633145000737 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 633145000738 dimer interface [polypeptide binding]; other site 633145000739 motif 1; other site 633145000740 motif 3; other site 633145000741 motif 2; other site 633145000742 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 633145000743 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 633145000744 dimer interface [polypeptide binding]; other site 633145000745 substrate binding site [chemical binding]; other site 633145000746 metal binding sites [ion binding]; metal-binding site 633145000747 prolyl-tRNA synthetase; Provisional; Region: PRK09194 633145000748 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 633145000749 dimer interface [polypeptide binding]; other site 633145000750 motif 1; other site 633145000751 active site 633145000752 motif 2; other site 633145000753 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 633145000754 putative deacylase active site [active] 633145000755 motif 3; other site 633145000756 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 633145000757 anticodon binding site; other site 633145000758 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 633145000759 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 633145000760 RIP metalloprotease RseP; Region: TIGR00054 633145000761 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 633145000762 active site 633145000763 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 633145000764 protein binding site [polypeptide binding]; other site 633145000765 putative substrate binding region [chemical binding]; other site 633145000766 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 633145000767 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 633145000768 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 633145000769 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 633145000770 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 633145000771 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 633145000772 active site 633145000773 dimer interface [polypeptide binding]; other site 633145000774 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 633145000775 hinge region; other site 633145000776 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 633145000777 putative nucleotide binding site [chemical binding]; other site 633145000778 uridine monophosphate binding site [chemical binding]; other site 633145000779 homohexameric interface [polypeptide binding]; other site 633145000780 elongation factor Ts; Reviewed; Region: tsf; PRK12332 633145000781 UBA/TS-N domain; Region: UBA; pfam00627 633145000782 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 633145000783 rRNA interaction site [nucleotide binding]; other site 633145000784 S8 interaction site; other site 633145000785 putative laminin-1 binding site; other site 633145000786 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 633145000787 putative active site [active] 633145000788 catalytic triad [active] 633145000789 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 633145000790 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 633145000791 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 633145000792 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 633145000793 dimerization interface [polypeptide binding]; other site 633145000794 ATP binding site [chemical binding]; other site 633145000795 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 633145000796 dimerization interface [polypeptide binding]; other site 633145000797 ATP binding site [chemical binding]; other site 633145000798 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 633145000799 active site 633145000800 multimer interface [polypeptide binding]; other site 633145000801 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 633145000802 iron-sulfur cluster [ion binding]; other site 633145000803 [2Fe-2S] cluster binding site [ion binding]; other site 633145000804 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 633145000805 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 633145000806 active site 633145000807 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 633145000808 putative SAM binding site [chemical binding]; other site 633145000809 putative homodimer interface [polypeptide binding]; other site 633145000810 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 633145000811 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 633145000812 active site 633145000813 HIGH motif; other site 633145000814 KMSKS motif; other site 633145000815 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 633145000816 tRNA binding surface [nucleotide binding]; other site 633145000817 anticodon binding site; other site 633145000818 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 633145000819 substrate binding pocket [chemical binding]; other site 633145000820 chain length determination region; other site 633145000821 substrate-Mg2+ binding site; other site 633145000822 catalytic residues [active] 633145000823 aspartate-rich region 1; other site 633145000824 active site lid residues [active] 633145000825 aspartate-rich region 2; other site 633145000826 FtsH Extracellular; Region: FtsH_ext; pfam06480 633145000827 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 633145000828 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633145000829 Walker A motif; other site 633145000830 ATP binding site [chemical binding]; other site 633145000831 Walker B motif; other site 633145000832 arginine finger; other site 633145000833 Peptidase family M41; Region: Peptidase_M41; pfam01434 633145000834 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 633145000835 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 633145000836 Oligomerization domain; Region: Oligomerization; pfam02410 633145000837 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 633145000838 active site 633145000839 multimer interface [polypeptide binding]; other site 633145000840 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 633145000841 Glycoprotease family; Region: Peptidase_M22; pfam00814 633145000842 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 633145000843 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633145000844 motif II; other site 633145000845 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 633145000846 thiamine monophosphate kinase; Provisional; Region: PRK05731 633145000847 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 633145000848 ATP binding site [chemical binding]; other site 633145000849 dimerization interface [polypeptide binding]; other site 633145000850 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 633145000851 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633145000852 S-adenosylmethionine binding site [chemical binding]; other site 633145000853 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 633145000854 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633145000855 S-adenosylmethionine binding site [chemical binding]; other site 633145000856 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 633145000857 active site 633145000858 NAD binding site [chemical binding]; other site 633145000859 metal binding site [ion binding]; metal-binding site 633145000860 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 633145000861 putative active site [active] 633145000862 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 633145000863 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633145000864 S-adenosylmethionine binding site [chemical binding]; other site 633145000865 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 633145000866 active site 633145000867 metal binding site [ion binding]; metal-binding site 633145000868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633145000869 S-adenosylmethionine binding site [chemical binding]; other site 633145000870 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 633145000871 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 633145000872 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 633145000873 Rubrerythrin [Energy production and conversion]; Region: COG1592 633145000874 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 633145000875 binuclear metal center [ion binding]; other site 633145000876 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 633145000877 iron binding site [ion binding]; other site 633145000878 Ion transport protein; Region: Ion_trans; pfam00520 633145000879 Ion channel; Region: Ion_trans_2; pfam07885 633145000880 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 633145000881 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 633145000882 active site 633145000883 NTP binding site [chemical binding]; other site 633145000884 metal binding triad [ion binding]; metal-binding site 633145000885 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 633145000886 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 633145000887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633145000888 Walker A/P-loop; other site 633145000889 ATP binding site [chemical binding]; other site 633145000890 Q-loop/lid; other site 633145000891 ABC transporter signature motif; other site 633145000892 Walker B; other site 633145000893 D-loop; other site 633145000894 H-loop/switch region; other site 633145000895 ABC-2 type transporter; Region: ABC2_membrane; cl17235 633145000896 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 633145000897 hypothetical protein; Provisional; Region: PRK01184 633145000898 AAA domain; Region: AAA_18; pfam13238 633145000899 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 633145000900 catalytic motif [active] 633145000901 Zn binding site [ion binding]; other site 633145000902 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 633145000903 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 633145000904 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 633145000905 trimer interface [polypeptide binding]; other site 633145000906 active site 633145000907 Probable zinc-binding domain; Region: zf-trcl; pfam13451 633145000908 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 633145000909 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 633145000910 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 633145000911 Walker A/P-loop; other site 633145000912 ATP binding site [chemical binding]; other site 633145000913 Q-loop/lid; other site 633145000914 ABC transporter signature motif; other site 633145000915 Walker B; other site 633145000916 D-loop; other site 633145000917 H-loop/switch region; other site 633145000918 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 633145000919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633145000920 dimer interface [polypeptide binding]; other site 633145000921 conserved gate region; other site 633145000922 putative PBP binding loops; other site 633145000923 ABC-ATPase subunit interface; other site 633145000924 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 633145000925 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 633145000926 substrate binding pocket [chemical binding]; other site 633145000927 membrane-bound complex binding site; other site 633145000928 hinge residues; other site 633145000929 EDD domain protein, DegV family; Region: DegV; TIGR00762 633145000930 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 633145000931 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 633145000932 oligomer interface [polypeptide binding]; other site 633145000933 metal binding site [ion binding]; metal-binding site 633145000934 metal binding site [ion binding]; metal-binding site 633145000935 putative Cl binding site [ion binding]; other site 633145000936 aspartate ring; other site 633145000937 basic sphincter; other site 633145000938 hydrophobic gate; other site 633145000939 periplasmic entrance; other site 633145000940 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 633145000941 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 633145000942 Mut7-C RNAse domain; Region: Mut7-C; pfam01927 633145000943 putative carbohydrate kinase; Provisional; Region: PRK10565 633145000944 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 633145000945 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 633145000946 putative substrate binding site [chemical binding]; other site 633145000947 putative ATP binding site [chemical binding]; other site 633145000948 pantothenate kinase; Reviewed; Region: PRK13321 633145000949 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 633145000950 Flavoprotein; Region: Flavoprotein; cl19190 633145000951 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 633145000952 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 633145000953 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 633145000954 active site 633145000955 HIGH motif; other site 633145000956 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 633145000957 KMSKS motif; other site 633145000958 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 633145000959 tRNA binding surface [nucleotide binding]; other site 633145000960 anticodon binding site; other site 633145000961 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 633145000962 PAS domain S-box; Region: sensory_box; TIGR00229 633145000963 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145000964 putative active site [active] 633145000965 heme pocket [chemical binding]; other site 633145000966 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 633145000967 Histidine kinase; Region: HisKA_3; pfam07730 633145000968 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633145000969 ATP binding site [chemical binding]; other site 633145000970 Mg2+ binding site [ion binding]; other site 633145000971 G-X-G motif; other site 633145000972 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 633145000973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633145000974 active site 633145000975 phosphorylation site [posttranslational modification] 633145000976 intermolecular recognition site; other site 633145000977 dimerization interface [polypeptide binding]; other site 633145000978 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 633145000979 DNA binding residues [nucleotide binding] 633145000980 dimerization interface [polypeptide binding]; other site 633145000981 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 633145000982 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 633145000983 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633145000984 nucleotide binding region [chemical binding]; other site 633145000985 ATP-binding site [chemical binding]; other site 633145000986 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 633145000987 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 633145000988 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 633145000989 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633145000990 active site 633145000991 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 633145000992 dimer interface [polypeptide binding]; other site 633145000993 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 633145000994 active site 633145000995 glycine-pyridoxal phosphate binding site [chemical binding]; other site 633145000996 folate binding site [chemical binding]; other site 633145000997 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 633145000998 Fe-S cluster binding site [ion binding]; other site 633145000999 active site 633145001000 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 633145001001 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 633145001002 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 633145001003 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 633145001004 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 633145001005 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 633145001006 excinuclease ABC subunit B; Provisional; Region: PRK05298 633145001007 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633145001008 ATP binding site [chemical binding]; other site 633145001009 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633145001010 nucleotide binding region [chemical binding]; other site 633145001011 ATP-binding site [chemical binding]; other site 633145001012 Ultra-violet resistance protein B; Region: UvrB; pfam12344 633145001013 UvrB/uvrC motif; Region: UVR; pfam02151 633145001014 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14605 633145001015 RuvA N terminal domain; Region: RuvA_N; pfam01330 633145001016 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 633145001017 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 633145001018 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 633145001019 active site 633145001020 putative DNA-binding cleft [nucleotide binding]; other site 633145001021 dimer interface [polypeptide binding]; other site 633145001022 hypothetical protein; Validated; Region: PRK00110 633145001023 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 633145001024 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 633145001025 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 633145001026 putative dimer interface [polypeptide binding]; other site 633145001027 [2Fe-2S] cluster binding site [ion binding]; other site 633145001028 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 633145001029 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 633145001030 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 633145001031 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 633145001032 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 633145001033 substrate binding site [chemical binding]; other site 633145001034 ligand binding site [chemical binding]; other site 633145001035 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 633145001036 substrate binding site [chemical binding]; other site 633145001037 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 633145001038 malate dehydrogenase; Reviewed; Region: PRK06223 633145001039 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 633145001040 NAD(P) binding site [chemical binding]; other site 633145001041 dimer interface [polypeptide binding]; other site 633145001042 tetramer (dimer of dimers) interface [polypeptide binding]; other site 633145001043 substrate binding site [chemical binding]; other site 633145001044 fumarate hydratase; Provisional; Region: PRK06246 633145001045 Fumarase C-terminus; Region: Fumerase_C; cl00795 633145001046 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 633145001047 nucleotide binding site/active site [active] 633145001048 catalytic residue [active] 633145001049 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 633145001050 dimer interface [polypeptide binding]; other site 633145001051 ADP-ribose binding site [chemical binding]; other site 633145001052 active site 633145001053 nudix motif; other site 633145001054 metal binding site [ion binding]; metal-binding site 633145001055 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 633145001056 Coenzyme A binding pocket [chemical binding]; other site 633145001057 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 633145001058 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 633145001059 arogenate dehydrogenase; Region: PLN02256 633145001060 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 633145001061 Chorismate mutase type II; Region: CM_2; smart00830 633145001062 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 633145001063 Prephenate dehydratase; Region: PDT; pfam00800 633145001064 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 633145001065 putative L-Phe binding site [chemical binding]; other site 633145001066 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 633145001067 Tetramer interface [polypeptide binding]; other site 633145001068 active site 633145001069 FMN-binding site [chemical binding]; other site 633145001070 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 633145001071 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 633145001072 hinge; other site 633145001073 active site 633145001074 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 633145001075 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 633145001076 ADP binding site [chemical binding]; other site 633145001077 magnesium binding site [ion binding]; other site 633145001078 putative shikimate binding site; other site 633145001079 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 633145001080 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 633145001081 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 633145001082 shikimate binding site; other site 633145001083 NAD(P) binding site [chemical binding]; other site 633145001084 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 633145001085 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 633145001086 active site 633145001087 catalytic residue [active] 633145001088 dimer interface [polypeptide binding]; other site 633145001089 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 633145001090 active site 633145001091 dimer interface [polypeptide binding]; other site 633145001092 metal binding site [ion binding]; metal-binding site 633145001093 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 633145001094 DAHP synthetase I family; Region: DAHP_synth_1; cl17225 633145001095 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 633145001096 S17 interaction site [polypeptide binding]; other site 633145001097 S8 interaction site; other site 633145001098 16S rRNA interaction site [nucleotide binding]; other site 633145001099 streptomycin interaction site [chemical binding]; other site 633145001100 23S rRNA interaction site [nucleotide binding]; other site 633145001101 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 633145001102 30S ribosomal protein S7; Validated; Region: PRK05302 633145001103 elongation factor G; Reviewed; Region: PRK12739 633145001104 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 633145001105 G1 box; other site 633145001106 putative GEF interaction site [polypeptide binding]; other site 633145001107 GTP/Mg2+ binding site [chemical binding]; other site 633145001108 Switch I region; other site 633145001109 G2 box; other site 633145001110 G3 box; other site 633145001111 Switch II region; other site 633145001112 G4 box; other site 633145001113 G5 box; other site 633145001114 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 633145001115 Elongation Factor G, domain II; Region: EFG_II; pfam14492 633145001116 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 633145001117 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 633145001118 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 633145001119 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 633145001120 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 633145001121 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 633145001122 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 633145001123 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 633145001124 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 633145001125 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 633145001126 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 633145001127 putative translocon binding site; other site 633145001128 protein-rRNA interface [nucleotide binding]; other site 633145001129 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 633145001130 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 633145001131 G-X-X-G motif; other site 633145001132 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 633145001133 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 633145001134 23S rRNA interface [nucleotide binding]; other site 633145001135 5S rRNA interface [nucleotide binding]; other site 633145001136 putative antibiotic binding site [chemical binding]; other site 633145001137 L25 interface [polypeptide binding]; other site 633145001138 L27 interface [polypeptide binding]; other site 633145001139 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 633145001140 23S rRNA interface [nucleotide binding]; other site 633145001141 putative translocon interaction site; other site 633145001142 signal recognition particle (SRP54) interaction site; other site 633145001143 L23 interface [polypeptide binding]; other site 633145001144 trigger factor interaction site; other site 633145001145 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 633145001146 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 633145001147 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 633145001148 RNA binding site [nucleotide binding]; other site 633145001149 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 633145001150 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 633145001151 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 633145001152 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 633145001153 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 633145001154 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 633145001155 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 633145001156 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 633145001157 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 633145001158 5S rRNA interface [nucleotide binding]; other site 633145001159 L27 interface [polypeptide binding]; other site 633145001160 23S rRNA interface [nucleotide binding]; other site 633145001161 L5 interface [polypeptide binding]; other site 633145001162 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 633145001163 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 633145001164 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 633145001165 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 633145001166 23S rRNA binding site [nucleotide binding]; other site 633145001167 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 633145001168 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 633145001169 SecY translocase; Region: SecY; pfam00344 633145001170 adenylate kinase; Reviewed; Region: adk; PRK00279 633145001171 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 633145001172 AMP-binding site [chemical binding]; other site 633145001173 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 633145001174 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 633145001175 active site 633145001176 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 633145001177 rRNA binding site [nucleotide binding]; other site 633145001178 predicted 30S ribosome binding site; other site 633145001179 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 633145001180 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 633145001181 30S ribosomal protein S13; Region: bact_S13; TIGR03631 633145001182 30S ribosomal protein S11; Validated; Region: PRK05309 633145001183 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 633145001184 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 633145001185 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 633145001186 RNA binding surface [nucleotide binding]; other site 633145001187 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 633145001188 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 633145001189 alphaNTD - beta interaction site [polypeptide binding]; other site 633145001190 alphaNTD homodimer interface [polypeptide binding]; other site 633145001191 alphaNTD - beta' interaction site [polypeptide binding]; other site 633145001192 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 633145001193 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 633145001194 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 633145001195 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 633145001196 dimerization interface 3.5A [polypeptide binding]; other site 633145001197 active site 633145001198 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 633145001199 23S rRNA interface [nucleotide binding]; other site 633145001200 L3 interface [polypeptide binding]; other site 633145001201 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 633145001202 Domain of unknown function (DUF202); Region: DUF202; pfam02656 633145001203 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 633145001204 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_1; cd05017 633145001205 dimer interface [polypeptide binding]; other site 633145001206 active site 633145001207 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 633145001208 dimer interface [polypeptide binding]; other site 633145001209 active site 633145001210 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 633145001211 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 633145001212 active site 633145001213 substrate binding site [chemical binding]; other site 633145001214 metal binding site [ion binding]; metal-binding site 633145001215 S-adenosylmethionine synthetase; Validated; Region: PRK05250 633145001216 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 633145001217 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 633145001218 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 633145001219 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 633145001220 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 633145001221 homotetramer interface [polypeptide binding]; other site 633145001222 ligand binding site [chemical binding]; other site 633145001223 catalytic site [active] 633145001224 NAD binding site [chemical binding]; other site 633145001225 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 633145001226 Predicted kinase [General function prediction only]; Region: COG0645 633145001227 AAA domain; Region: AAA_33; pfam13671 633145001228 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 633145001229 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 633145001230 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 633145001231 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 633145001232 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 633145001233 ABC-2 type transporter; Region: ABC2_membrane; cl17235 633145001234 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633145001235 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 633145001236 Walker A/P-loop; other site 633145001237 ATP binding site [chemical binding]; other site 633145001238 Q-loop/lid; other site 633145001239 ABC transporter signature motif; other site 633145001240 Walker B; other site 633145001241 D-loop; other site 633145001242 H-loop/switch region; other site 633145001243 N-terminal half of MaoC dehydratase; Region: MaoC_dehydrat_N; pfam13452 633145001244 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 633145001245 active site 633145001246 catalytic site [active] 633145001247 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 633145001248 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 633145001249 HEAT repeats; Region: HEAT_2; pfam13646 633145001250 HEAT repeats; Region: HEAT_2; pfam13646 633145001251 HEAT repeats; Region: HEAT_2; pfam13646 633145001252 PAC2 family; Region: PAC2; pfam09754 633145001253 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 633145001254 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 633145001255 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 633145001256 This archaeal PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar...; Region: PGM_like1; cd03087 633145001257 active site 633145001258 substrate binding site [chemical binding]; other site 633145001259 metal binding site [ion binding]; metal-binding site 633145001260 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: Arch_glmU; TIGR03992 633145001261 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 633145001262 active site 633145001263 Substrate binding site; other site 633145001264 Mg++ binding site; other site 633145001265 Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636 633145001266 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: Arch_glmU; TIGR03992 633145001267 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 633145001268 active site 633145001269 Substrate binding site; other site 633145001270 Mg++ binding site; other site 633145001271 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 633145001272 putative trimer interface [polypeptide binding]; other site 633145001273 putative CoA binding site [chemical binding]; other site 633145001274 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 633145001275 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 633145001276 glutaminase active site [active] 633145001277 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 633145001278 dimer interface [polypeptide binding]; other site 633145001279 active site 633145001280 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 633145001281 dimer interface [polypeptide binding]; other site 633145001282 active site 633145001283 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 633145001284 substrate binding site [chemical binding]; other site 633145001285 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 633145001286 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633145001287 motif II; other site 633145001288 diaminopimelate decarboxylase; Region: lysA; TIGR01048 633145001289 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 633145001290 active site 633145001291 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 633145001292 substrate binding site [chemical binding]; other site 633145001293 catalytic residues [active] 633145001294 dimer interface [polypeptide binding]; other site 633145001295 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633145001296 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 633145001297 Walker A motif; other site 633145001298 ATP binding site [chemical binding]; other site 633145001299 Walker B motif; other site 633145001300 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 633145001301 arginine finger; other site 633145001302 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 633145001303 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 633145001304 active site 633145001305 hypothetical protein; Provisional; Region: PRK06921 633145001306 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633145001307 Walker A motif; other site 633145001308 ATP binding site [chemical binding]; other site 633145001309 Walker B motif; other site 633145001310 arginine finger; other site 633145001311 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633145001312 Walker A motif; other site 633145001313 ATP binding site [chemical binding]; other site 633145001314 Walker B motif; other site 633145001315 arginine finger; other site 633145001316 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 633145001317 replicative DNA helicase; Region: DnaB; TIGR00665 633145001318 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 633145001319 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 633145001320 Walker A motif; other site 633145001321 ATP binding site [chemical binding]; other site 633145001322 Walker B motif; other site 633145001323 DNA binding loops [nucleotide binding] 633145001324 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 633145001325 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 633145001326 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 633145001327 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 633145001328 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 633145001329 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 633145001330 putative phosphate acyltransferase; Provisional; Region: PRK05331 633145001331 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 633145001332 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 633145001333 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 633145001334 metal binding site [ion binding]; metal-binding site 633145001335 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 633145001336 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 633145001337 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 633145001338 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 633145001339 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 633145001340 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 633145001341 non-specific DNA binding site [nucleotide binding]; other site 633145001342 salt bridge; other site 633145001343 sequence-specific DNA binding site [nucleotide binding]; other site 633145001344 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 633145001345 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 633145001346 Walker A/P-loop; other site 633145001347 ATP binding site [chemical binding]; other site 633145001348 Q-loop/lid; other site 633145001349 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 633145001350 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 633145001351 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 633145001352 ABC transporter signature motif; other site 633145001353 Walker B; other site 633145001354 D-loop; other site 633145001355 H-loop/switch region; other site 633145001356 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 633145001357 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 633145001358 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 633145001359 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 633145001360 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 633145001361 DNA binding residues [nucleotide binding] 633145001362 DNA primase; Validated; Region: dnaG; PRK05667 633145001363 CHC2 zinc finger; Region: zf-CHC2; cl17510 633145001364 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 633145001365 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 633145001366 active site 633145001367 metal binding site [ion binding]; metal-binding site 633145001368 interdomain interaction site; other site 633145001369 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 633145001370 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 633145001371 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 633145001372 Zn2+ binding site [ion binding]; other site 633145001373 Mg2+ binding site [ion binding]; other site 633145001374 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 633145001375 phosphoenolpyruvate synthase; Validated; Region: PRK06464 633145001376 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 633145001377 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 633145001378 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 633145001379 Bifunctional nuclease; Region: DNase-RNase; pfam02577 633145001380 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 633145001381 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 633145001382 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 633145001383 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 633145001384 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 633145001385 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 633145001386 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 633145001387 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 633145001388 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 633145001389 beta subunit interaction interface [polypeptide binding]; other site 633145001390 Walker A motif; other site 633145001391 ATP binding site [chemical binding]; other site 633145001392 Walker B motif; other site 633145001393 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 633145001394 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 633145001395 core domain interface [polypeptide binding]; other site 633145001396 delta subunit interface [polypeptide binding]; other site 633145001397 epsilon subunit interface [polypeptide binding]; other site 633145001398 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 633145001399 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 633145001400 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 633145001401 alpha subunit interaction interface [polypeptide binding]; other site 633145001402 Walker A motif; other site 633145001403 ATP binding site [chemical binding]; other site 633145001404 Walker B motif; other site 633145001405 inhibitor binding site; inhibition site 633145001406 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 633145001407 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 633145001408 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 633145001409 gamma subunit interface [polypeptide binding]; other site 633145001410 epsilon subunit interface [polypeptide binding]; other site 633145001411 LBP interface [polypeptide binding]; other site 633145001412 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 633145001413 RimM N-terminal domain; Region: RimM; pfam01782 633145001414 PRC-barrel domain; Region: PRC; pfam05239 633145001415 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 633145001416 KH domain; Region: KH_4; pfam13083 633145001417 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 633145001418 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 633145001419 Active_site [active] 633145001420 peptide chain release factor 2; Validated; Region: prfB; PRK00578 633145001421 PCRF domain; Region: PCRF; pfam03462 633145001422 RF-1 domain; Region: RF-1; pfam00472 633145001423 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 633145001424 Zn binding site [ion binding]; other site 633145001425 hypothetical protein; Reviewed; Region: PRK00024 633145001426 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 633145001427 helix-hairpin-helix signature motif; other site 633145001428 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 633145001429 MPN+ (JAMM) motif; other site 633145001430 substrate binding pocket [chemical binding]; other site 633145001431 Zinc-binding site [ion binding]; other site 633145001432 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 633145001433 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 633145001434 peptide binding site [polypeptide binding]; other site 633145001435 capreomycidine synthase; Region: viomycin_VioD; TIGR03947 633145001436 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 633145001437 pyridoxal 5'-phosphate binding site [chemical binding]; other site 633145001438 homodimer interface [polypeptide binding]; other site 633145001439 catalytic residue [active] 633145001440 seryl-tRNA synthetase; Provisional; Region: PRK05431 633145001441 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 633145001442 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 633145001443 dimer interface [polypeptide binding]; other site 633145001444 active site 633145001445 motif 1; other site 633145001446 motif 2; other site 633145001447 motif 3; other site 633145001448 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 633145001449 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 633145001450 dimer interface [polypeptide binding]; other site 633145001451 putative anticodon binding site; other site 633145001452 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 633145001453 motif 1; other site 633145001454 active site 633145001455 motif 2; other site 633145001456 motif 3; other site 633145001457 Recombination protein O N terminal; Region: RecO_N; pfam11967 633145001458 DNA repair protein RecO; Region: reco; TIGR00613 633145001459 Recombination protein O C terminal; Region: RecO_C; pfam02565 633145001460 A new structural DNA glycosylase; Region: AlkD_like; cd06561 633145001461 active site 633145001462 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 633145001463 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 633145001464 oligomer interface [polypeptide binding]; other site 633145001465 metal binding site [ion binding]; metal-binding site 633145001466 metal binding site [ion binding]; metal-binding site 633145001467 Cl binding site [ion binding]; other site 633145001468 aspartate ring; other site 633145001469 basic sphincter; other site 633145001470 putative hydrophobic gate; other site 633145001471 periplasmic entrance; other site 633145001472 recombination protein RecR; Reviewed; Region: recR; PRK00076 633145001473 RecR protein; Region: RecR; pfam02132 633145001474 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 633145001475 putative active site [active] 633145001476 putative metal-binding site [ion binding]; other site 633145001477 tetramer interface [polypeptide binding]; other site 633145001478 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 633145001479 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 633145001480 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633145001481 Walker A motif; other site 633145001482 ATP binding site [chemical binding]; other site 633145001483 Walker B motif; other site 633145001484 arginine finger; other site 633145001485 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 633145001486 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 633145001487 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 633145001488 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type2; cd02202 633145001489 Tubulin/FtsZ family, GTPase domain; Region: Tubulin; pfam00091 633145001490 nucleotide binding site [chemical binding]; other site 633145001491 SulA interaction site; other site 633145001492 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 633145001493 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 633145001494 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 633145001495 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 633145001496 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 633145001497 enolase; Provisional; Region: eno; PRK00077 633145001498 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 633145001499 dimer interface [polypeptide binding]; other site 633145001500 metal binding site [ion binding]; metal-binding site 633145001501 substrate binding pocket [chemical binding]; other site 633145001502 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 633145001503 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 633145001504 putative active site [active] 633145001505 catalytic residue [active] 633145001506 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 633145001507 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 633145001508 nucleotide binding pocket [chemical binding]; other site 633145001509 K-X-D-G motif; other site 633145001510 catalytic site [active] 633145001511 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 633145001512 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 633145001513 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 633145001514 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 633145001515 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 633145001516 Dimer interface [polypeptide binding]; other site 633145001517 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 633145001518 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 633145001519 predicted active site [active] 633145001520 catalytic triad [active] 633145001521 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 633145001522 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 633145001523 ligand binding site [chemical binding]; other site 633145001524 NAD binding site [chemical binding]; other site 633145001525 dimerization interface [polypeptide binding]; other site 633145001526 catalytic site [active] 633145001527 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 633145001528 putative L-serine binding site [chemical binding]; other site 633145001529 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 633145001530 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 633145001531 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 633145001532 catalytic residue [active] 633145001533 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 633145001534 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 633145001535 active site 633145001536 HIGH motif; other site 633145001537 dimer interface [polypeptide binding]; other site 633145001538 KMSKS motif; other site 633145001539 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 633145001540 RNA binding surface [nucleotide binding]; other site 633145001541 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 633145001542 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 633145001543 active site 633145001544 Riboflavin kinase; Region: Flavokinase; pfam01687 633145001545 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 633145001546 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 633145001547 RPB12 interaction site [polypeptide binding]; other site 633145001548 RPB1 interaction site [polypeptide binding]; other site 633145001549 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 633145001550 RPB10 interaction site [polypeptide binding]; other site 633145001551 RPB11 interaction site [polypeptide binding]; other site 633145001552 RPB3 interaction site [polypeptide binding]; other site 633145001553 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 633145001554 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 633145001555 beta and beta' interface [polypeptide binding]; other site 633145001556 beta' and sigma factor interface [polypeptide binding]; other site 633145001557 Zn-binding [ion binding]; other site 633145001558 active site region [active] 633145001559 catalytic site [active] 633145001560 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 633145001561 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 633145001562 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 633145001563 G-loop; other site 633145001564 DNA binding site [nucleotide binding] 633145001565 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 633145001566 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 633145001567 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633145001568 Walker A motif; other site 633145001569 ATP binding site [chemical binding]; other site 633145001570 Walker B motif; other site 633145001571 arginine finger; other site 633145001572 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 633145001573 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 633145001574 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 633145001575 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 633145001576 Coenzyme A binding pocket [chemical binding]; other site 633145001577 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 633145001578 Predicted permease; Region: DUF318; cl17795 633145001579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633145001580 S-adenosylmethionine binding site [chemical binding]; other site 633145001581 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 633145001582 FeS/SAM binding site; other site 633145001583 Radical SAM superfamily; Region: Radical_SAM; pfam04055 633145001584 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 633145001585 Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941 633145001586 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 633145001587 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 633145001588 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 633145001589 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 633145001590 Endopeptidases belonging to F420-reducing hydrogenases group. These hydrogenases from methanogens are encoded by the fru, frc, or frh genes. Sequence comparison indicates that fruD and frcD gene products from Methanococcus voltae are similar to HycI...; Region: H2MP_F420-Reduc; cd06064 633145001591 nickel binding site [ion binding]; other site 633145001592 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 633145001593 catalytic residues [active] 633145001594 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 633145001595 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 633145001596 Putative small multi-drug export protein; Region: Sm_multidrug_ex; cl01024 633145001597 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 633145001598 FeS/SAM binding site; other site 633145001599 Radical SAM superfamily; Region: Radical_SAM; pfam04055 633145001600 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 633145001601 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 633145001602 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 633145001603 active site 633145001604 effector binding site; other site 633145001605 dimer interface [polypeptide binding]; other site 633145001606 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 633145001607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633145001608 active site 633145001609 phosphorylation site [posttranslational modification] 633145001610 intermolecular recognition site; other site 633145001611 dimerization interface [polypeptide binding]; other site 633145001612 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 633145001613 Zn2+ binding site [ion binding]; other site 633145001614 Mg2+ binding site [ion binding]; other site 633145001615 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 633145001616 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145001617 putative active site [active] 633145001618 heme pocket [chemical binding]; other site 633145001619 PAS domain; Region: PAS; smart00091 633145001620 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 633145001621 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 633145001622 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145001623 putative active site [active] 633145001624 heme pocket [chemical binding]; other site 633145001625 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 633145001626 dimer interface [polypeptide binding]; other site 633145001627 phosphorylation site [posttranslational modification] 633145001628 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633145001629 ATP binding site [chemical binding]; other site 633145001630 Mg2+ binding site [ion binding]; other site 633145001631 G-X-G motif; other site 633145001632 Putative zinc- or iron-chelating domain; Region: CxxCxxCC; pfam03692 633145001633 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 633145001634 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 633145001635 FeS/SAM binding site; other site 633145001636 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 633145001637 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 633145001638 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 633145001639 ATP-grasp domain; Region: ATP-grasp_4; cl17255 633145001640 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 633145001641 metal binding site 2 [ion binding]; metal-binding site 633145001642 putative DNA binding helix; other site 633145001643 metal binding site 1 [ion binding]; metal-binding site 633145001644 dimer interface [polypeptide binding]; other site 633145001645 structural Zn2+ binding site [ion binding]; other site 633145001646 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 633145001647 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 633145001648 intersubunit interface [polypeptide binding]; other site 633145001649 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 633145001650 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 633145001651 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 633145001652 ABC-ATPase subunit interface; other site 633145001653 dimer interface [polypeptide binding]; other site 633145001654 putative PBP binding regions; other site 633145001655 cell division protein FtsZ; Validated; Region: PRK09330 633145001656 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 633145001657 nucleotide binding site [chemical binding]; other site 633145001658 SulA interaction site; other site 633145001659 cell division protein FtsA; Region: ftsA; TIGR01174 633145001660 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 633145001661 nucleotide binding site [chemical binding]; other site 633145001662 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 633145001663 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 633145001664 Cell division protein FtsA; Region: FtsA; pfam14450 633145001665 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 633145001666 Ligand Binding Site [chemical binding]; other site 633145001667 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 633145001668 Ligand Binding Site [chemical binding]; other site 633145001669 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 633145001670 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 633145001671 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 633145001672 substrate binding site [chemical binding]; other site 633145001673 hexamer interface [polypeptide binding]; other site 633145001674 metal binding site [ion binding]; metal-binding site 633145001675 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 633145001676 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 633145001677 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 633145001678 TPP-binding site [chemical binding]; other site 633145001679 dimer interface [polypeptide binding]; other site 633145001680 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 633145001681 PYR/PP interface [polypeptide binding]; other site 633145001682 dimer interface [polypeptide binding]; other site 633145001683 TPP binding site [chemical binding]; other site 633145001684 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 633145001685 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 633145001686 putative FMN binding site [chemical binding]; other site 633145001687 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 633145001688 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633145001689 S-adenosylmethionine binding site [chemical binding]; other site 633145001690 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 633145001691 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 633145001692 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 633145001693 cobalamin binding residues [chemical binding]; other site 633145001694 putative BtuC binding residues; other site 633145001695 dimer interface [polypeptide binding]; other site 633145001696 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 633145001697 ABC-ATPase subunit interface; other site 633145001698 dimer interface [polypeptide binding]; other site 633145001699 putative PBP binding regions; other site 633145001700 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 633145001701 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 633145001702 Walker A/P-loop; other site 633145001703 ATP binding site [chemical binding]; other site 633145001704 Q-loop/lid; other site 633145001705 ABC transporter signature motif; other site 633145001706 Walker B; other site 633145001707 D-loop; other site 633145001708 H-loop/switch region; other site 633145001709 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 633145001710 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 633145001711 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 633145001712 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 633145001713 pyridoxal 5'-phosphate binding site [chemical binding]; other site 633145001714 homodimer interface [polypeptide binding]; other site 633145001715 catalytic residue [active] 633145001716 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 633145001717 putative dimer interface [polypeptide binding]; other site 633145001718 active site pocket [active] 633145001719 putative cataytic base [active] 633145001720 cobalamin synthase; Reviewed; Region: cobS; PRK00235 633145001721 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 633145001722 catalytic core [active] 633145001723 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; pfam02283 633145001724 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 633145001725 catalytic residues [active] 633145001726 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 633145001727 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 633145001728 Histidine kinase; Region: HisKA_3; pfam07730 633145001729 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633145001730 ATP binding site [chemical binding]; other site 633145001731 Mg2+ binding site [ion binding]; other site 633145001732 G-X-G motif; other site 633145001733 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 633145001734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633145001735 active site 633145001736 phosphorylation site [posttranslational modification] 633145001737 intermolecular recognition site; other site 633145001738 dimerization interface [polypeptide binding]; other site 633145001739 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 633145001740 DNA binding residues [nucleotide binding] 633145001741 dimerization interface [polypeptide binding]; other site 633145001742 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 633145001743 acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional; Region: PRK04165 633145001744 Putative Fe-S cluster; Region: FeS; pfam04060 633145001745 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 633145001746 bifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta; Reviewed; Region: PRK09529 633145001747 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 633145001748 ACS interaction site; other site 633145001749 CODH interaction site; other site 633145001750 metal cluster binding site [ion binding]; other site 633145001751 CO dehydrogenase/acetyl-CoA synthase complex beta subunit; Region: CdhC; pfam03598 633145001752 acetyl-CoA decarbonylase/synthase complex subunit delta; Provisional; Region: PRK04452 633145001753 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 633145001754 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 633145001755 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 633145001756 homodimer interface [polypeptide binding]; other site 633145001757 NADP binding site [chemical binding]; other site 633145001758 substrate binding site [chemical binding]; other site 633145001759 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 633145001760 P-loop; other site 633145001761 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 633145001762 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 633145001763 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 633145001764 catalytic loop [active] 633145001765 iron binding site [ion binding]; other site 633145001766 Domain of unknown function (DUF4445); Region: DUF4445; pfam14574 633145001767 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 633145001768 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 633145001769 Potassium binding sites [ion binding]; other site 633145001770 Cesium cation binding sites [ion binding]; other site 633145001771 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 633145001772 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 633145001773 dimer interface [polypeptide binding]; other site 633145001774 anticodon binding site; other site 633145001775 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 633145001776 homodimer interface [polypeptide binding]; other site 633145001777 motif 1; other site 633145001778 active site 633145001779 motif 2; other site 633145001780 GAD domain; Region: GAD; pfam02938 633145001781 motif 3; other site 633145001782 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 633145001783 trigger factor; Region: tig; TIGR00115 633145001784 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 633145001785 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 633145001786 oligomer interface [polypeptide binding]; other site 633145001787 active site residues [active] 633145001788 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 633145001789 substrate binding site [chemical binding]; other site 633145001790 ATP binding site [chemical binding]; other site 633145001791 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 633145001792 substrate binding site [chemical binding]; other site 633145001793 active site 633145001794 cosubstrate binding site; other site 633145001795 catalytic site [active] 633145001796 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 633145001797 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 633145001798 active site 633145001799 PHP-associated; Region: PHP_C; pfam13263 633145001800 translation elongation factor P; Region: efp; TIGR00038 633145001801 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 633145001802 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 633145001803 RNA binding site [nucleotide binding]; other site 633145001804 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 633145001805 RNA binding site [nucleotide binding]; other site 633145001806 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 633145001807 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 633145001808 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 633145001809 active site 633145001810 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 633145001811 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 633145001812 active site 633145001813 Int/Topo IB signature motif; other site 633145001814 DNA topoisomerase I; Validated; Region: PRK05582 633145001815 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 633145001816 active site 633145001817 interdomain interaction site; other site 633145001818 putative metal-binding site [ion binding]; other site 633145001819 nucleotide binding site [chemical binding]; other site 633145001820 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 633145001821 domain I; other site 633145001822 DNA binding groove [nucleotide binding] 633145001823 phosphate binding site [ion binding]; other site 633145001824 domain II; other site 633145001825 domain III; other site 633145001826 nucleotide binding site [chemical binding]; other site 633145001827 catalytic site [active] 633145001828 domain IV; other site 633145001829 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 633145001830 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 633145001831 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 633145001832 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 633145001833 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 633145001834 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 633145001835 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; Region: PorC_KorC; TIGR02175 633145001836 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 633145001837 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179 633145001838 pyruvate ferredoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK08367 633145001839 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 633145001840 dimer interface [polypeptide binding]; other site 633145001841 PYR/PP interface [polypeptide binding]; other site 633145001842 TPP binding site [chemical binding]; other site 633145001843 substrate binding site [chemical binding]; other site 633145001844 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 633145001845 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 633145001846 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 633145001847 TPP-binding site [chemical binding]; other site 633145001848 putative dimer interface [polypeptide binding]; other site 633145001849 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 633145001850 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 633145001851 putative dimer interface [polypeptide binding]; other site 633145001852 [2Fe-2S] cluster binding site [ion binding]; other site 633145001853 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 633145001854 dimer interface [polypeptide binding]; other site 633145001855 [2Fe-2S] cluster binding site [ion binding]; other site 633145001856 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 633145001857 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 633145001858 SLBB domain; Region: SLBB; pfam10531 633145001859 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 633145001860 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 633145001861 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 633145001862 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 633145001863 catalytic loop [active] 633145001864 iron binding site [ion binding]; other site 633145001865 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 633145001866 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 633145001867 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 633145001868 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 633145001869 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 633145001870 Moco binding site; other site 633145001871 metal coordination site [ion binding]; other site 633145001872 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 633145001873 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 633145001874 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 633145001875 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 633145001876 Zinc ribbon domain; Region: Zn-ribbon_8; pfam09723 633145001877 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 633145001878 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633145001879 NAD(P) binding site [chemical binding]; other site 633145001880 active site 633145001881 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 633145001882 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 633145001883 HflX GTPase family; Region: HflX; cd01878 633145001884 G1 box; other site 633145001885 GTP/Mg2+ binding site [chemical binding]; other site 633145001886 Switch I region; other site 633145001887 G2 box; other site 633145001888 G3 box; other site 633145001889 Switch II region; other site 633145001890 G4 box; other site 633145001891 G5 box; other site 633145001892 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 633145001893 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 633145001894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 633145001895 homodimer interface [polypeptide binding]; other site 633145001896 catalytic residue [active] 633145001897 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 633145001898 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 633145001899 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 633145001900 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 633145001901 triosephosphate isomerase; Provisional; Region: PRK14565 633145001902 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 633145001903 substrate binding site [chemical binding]; other site 633145001904 dimer interface [polypeptide binding]; other site 633145001905 catalytic triad [active] 633145001906 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04135 633145001907 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 633145001908 substrate binding site [chemical binding]; other site 633145001909 hinge regions; other site 633145001910 ADP binding site [chemical binding]; other site 633145001911 catalytic site [active] 633145001912 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 633145001913 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 633145001914 TPP-binding site; other site 633145001915 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 633145001916 PYR/PP interface [polypeptide binding]; other site 633145001917 dimer interface [polypeptide binding]; other site 633145001918 TPP binding site [chemical binding]; other site 633145001919 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 633145001920 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 633145001921 GAF domain; Region: GAF_2; pfam13185 633145001922 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633145001923 active site 633145001924 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 633145001925 23S rRNA binding site [nucleotide binding]; other site 633145001926 L21 binding site [polypeptide binding]; other site 633145001927 L13 binding site [polypeptide binding]; other site 633145001928 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 633145001929 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 633145001930 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 633145001931 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 633145001932 active site 633145001933 dimer interface [polypeptide binding]; other site 633145001934 motif 1; other site 633145001935 motif 2; other site 633145001936 motif 3; other site 633145001937 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 633145001938 anticodon binding site; other site 633145001939 MAEBL; Provisional; Region: PTZ00121 633145001940 MAEBL; Provisional; Region: PTZ00121 633145001941 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 633145001942 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 633145001943 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 633145001944 catalytic residue [active] 633145001945 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 633145001946 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 633145001947 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 633145001948 active site 633145001949 catalytic residues [active] 633145001950 metal binding site [ion binding]; metal-binding site 633145001951 Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945 633145001952 Putative lysophospholipase; Region: Hydrolase_4; cl19140 633145001953 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 633145001954 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 633145001955 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 633145001956 Predicted membrane protein [Function unknown]; Region: COG4818 633145001957 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 633145001958 Peptidase family M50; Region: Peptidase_M50; pfam02163 633145001959 active site 633145001960 putative substrate binding region [chemical binding]; other site 633145001961 FOG: CBS domain [General function prediction only]; Region: COG0517 633145001962 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 633145001963 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 633145001964 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 633145001965 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 633145001966 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 633145001967 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 633145001968 CAAX protease self-immunity; Region: Abi; pfam02517 633145001969 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 633145001970 Peptidase family M50; Region: Peptidase_M50; pfam02163 633145001971 active site 633145001972 putative substrate binding region [chemical binding]; other site 633145001973 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 633145001974 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 633145001975 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 633145001976 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 633145001977 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633145001978 Walker A motif; other site 633145001979 ATP binding site [chemical binding]; other site 633145001980 Walker B motif; other site 633145001981 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 633145001982 RxxxH motif; other site 633145001983 thymidylate kinase; Validated; Region: tmk; PRK00698 633145001984 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 633145001985 TMP-binding site; other site 633145001986 ATP-binding site [chemical binding]; other site 633145001987 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 633145001988 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 633145001989 Ligand Binding Site [chemical binding]; other site 633145001990 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 633145001991 RNA/DNA hybrid binding site [nucleotide binding]; other site 633145001992 active site 633145001993 hypothetical protein; Provisional; Region: PRK14688 633145001994 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 633145001995 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 633145001996 thiamine phosphate binding site [chemical binding]; other site 633145001997 active site 633145001998 pyrophosphate binding site [ion binding]; other site 633145001999 haloacid dehalogenase superfamily protein; Provisional; Region: PRK14562 633145002000 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 633145002001 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 633145002002 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 633145002003 glycyl-tRNA synthetase; Provisional; Region: PRK04173 633145002004 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 633145002005 dimer interface [polypeptide binding]; other site 633145002006 motif 1; other site 633145002007 active site 633145002008 motif 2; other site 633145002009 motif 3; other site 633145002010 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 633145002011 anticodon binding site; other site 633145002012 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 633145002013 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 633145002014 active site 633145002015 metal binding site [ion binding]; metal-binding site 633145002016 DNA binding site [nucleotide binding] 633145002017 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 633145002018 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 633145002019 RNA binding surface [nucleotide binding]; other site 633145002020 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 633145002021 active site 633145002022 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633145002023 active site 633145002024 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 633145002025 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 633145002026 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 633145002027 active site 633145002028 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633145002029 active site 633145002030 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 633145002031 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 633145002032 Walker A/P-loop; other site 633145002033 ATP binding site [chemical binding]; other site 633145002034 Q-loop/lid; other site 633145002035 ABC transporter signature motif; other site 633145002036 Walker B; other site 633145002037 D-loop; other site 633145002038 H-loop/switch region; other site 633145002039 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 633145002040 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 633145002041 ABC-2 type transporter; Region: ABC2_membrane; cl17235 633145002042 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 633145002043 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 633145002044 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 633145002045 Uncharacterized conserved protein [Function unknown]; Region: COG5495 633145002046 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 633145002047 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 633145002048 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 633145002049 tetramerization interface [polypeptide binding]; other site 633145002050 active site 633145002051 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 633145002052 oligomerization interface [polypeptide binding]; other site 633145002053 active site 633145002054 metal binding site [ion binding]; metal-binding site 633145002055 Pantoate-beta-alanine ligase; Region: PanC; cd00560 633145002056 active site 633145002057 ATP-binding site [chemical binding]; other site 633145002058 pantoate-binding site; other site 633145002059 HXXH motif; other site 633145002060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633145002061 Major Facilitator Superfamily; Region: MFS_1; pfam07690 633145002062 putative substrate translocation pore; other site 633145002063 Transcriptional regulators [Transcription]; Region: MarR; COG1846 633145002064 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 633145002065 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 633145002066 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 633145002067 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 633145002068 Predicted membrane protein (DUF2070); Region: DUF2070; cl19221 633145002069 PAP2 superfamily; Region: PAP2; pfam01569 633145002070 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 633145002071 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633145002072 Walker A/P-loop; other site 633145002073 ATP binding site [chemical binding]; other site 633145002074 Q-loop/lid; other site 633145002075 ABC transporter signature motif; other site 633145002076 Walker B; other site 633145002077 D-loop; other site 633145002078 H-loop/switch region; other site 633145002079 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 633145002080 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 633145002081 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 633145002082 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 633145002083 Walker A/P-loop; other site 633145002084 ATP binding site [chemical binding]; other site 633145002085 Q-loop/lid; other site 633145002086 ABC transporter signature motif; other site 633145002087 Walker B; other site 633145002088 D-loop; other site 633145002089 H-loop/switch region; other site 633145002090 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 633145002091 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 633145002092 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 633145002093 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 633145002094 Walker A/P-loop; other site 633145002095 ATP binding site [chemical binding]; other site 633145002096 Q-loop/lid; other site 633145002097 ABC transporter signature motif; other site 633145002098 Walker B; other site 633145002099 D-loop; other site 633145002100 H-loop/switch region; other site 633145002101 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 633145002102 dimerization interface [polypeptide binding]; other site 633145002103 active site 633145002104 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 633145002105 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 633145002106 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 633145002107 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 633145002108 putative FMN binding site [chemical binding]; other site 633145002109 NADPH bind site [chemical binding]; other site 633145002110 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 633145002111 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 633145002112 active site 633145002113 catalytic residues [active] 633145002114 metal binding site [ion binding]; metal-binding site 633145002115 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 633145002116 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 633145002117 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 633145002118 substrate binding site [chemical binding]; other site 633145002119 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 633145002120 substrate binding site [chemical binding]; other site 633145002121 ligand binding site [chemical binding]; other site 633145002122 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 633145002123 MgtC family; Region: MgtC; pfam02308 633145002124 2-isopropylmalate synthase; Validated; Region: PRK00915 633145002125 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 633145002126 active site 633145002127 catalytic residues [active] 633145002128 metal binding site [ion binding]; metal-binding site 633145002129 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 633145002130 ketol-acid reductoisomerase; Provisional; Region: PRK05479 633145002131 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 633145002132 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 633145002133 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 633145002134 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 633145002135 putative valine binding site [chemical binding]; other site 633145002136 dimer interface [polypeptide binding]; other site 633145002137 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 633145002138 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 633145002139 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 633145002140 PYR/PP interface [polypeptide binding]; other site 633145002141 dimer interface [polypeptide binding]; other site 633145002142 TPP binding site [chemical binding]; other site 633145002143 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 633145002144 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 633145002145 TPP-binding site [chemical binding]; other site 633145002146 dimer interface [polypeptide binding]; other site 633145002147 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 633145002148 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 633145002149 GMP synthase; Reviewed; Region: guaA; PRK00074 633145002150 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 633145002151 AMP/PPi binding site [chemical binding]; other site 633145002152 candidate oxyanion hole; other site 633145002153 catalytic triad [active] 633145002154 potential glutamine specificity residues [chemical binding]; other site 633145002155 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 633145002156 ATP Binding subdomain [chemical binding]; other site 633145002157 Ligand Binding sites [chemical binding]; other site 633145002158 Dimerization subdomain; other site 633145002159 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 633145002160 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 633145002161 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 633145002162 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 633145002163 AIR carboxylase; Region: AIRC; pfam00731 633145002164 adenylosuccinate lyase; Provisional; Region: PRK07492 633145002165 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 633145002166 tetramer interface [polypeptide binding]; other site 633145002167 active site 633145002168 phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional; Region: PRK13959 633145002169 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 633145002170 active site 633145002171 ATP binding site [chemical binding]; other site 633145002172 substrate binding site [chemical binding]; other site 633145002173 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 633145002174 putative active site pocket [active] 633145002175 4-fold oligomerization interface [polypeptide binding]; other site 633145002176 metal binding residues [ion binding]; metal-binding site 633145002177 3-fold/trimer interface [polypeptide binding]; other site 633145002178 histidinol-phosphate aminotransferase; Provisional; Region: PLN03026 633145002179 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 633145002180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 633145002181 homodimer interface [polypeptide binding]; other site 633145002182 catalytic residue [active] 633145002183 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 633145002184 histidinol dehydrogenase; Region: hisD; TIGR00069 633145002185 NAD binding site [chemical binding]; other site 633145002186 dimerization interface [polypeptide binding]; other site 633145002187 product binding site; other site 633145002188 substrate binding site [chemical binding]; other site 633145002189 zinc binding site [ion binding]; other site 633145002190 catalytic residues [active] 633145002191 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 633145002192 ATP phosphoribosyltransferase; Region: HisG; cl15266 633145002193 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 633145002194 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 633145002195 dimer interface [polypeptide binding]; other site 633145002196 motif 1; other site 633145002197 active site 633145002198 motif 2; other site 633145002199 motif 3; other site 633145002200 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 633145002201 prohibitin homologues; Region: PHB; smart00244 633145002202 Uncharacterized prokaryotic subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_eoslipins_u1; cd08826 633145002203 trimer interface [polypeptide binding]; other site 633145002204 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 633145002205 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 633145002206 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 633145002207 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 633145002208 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 633145002209 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 633145002210 Walker A/P-loop; other site 633145002211 ATP binding site [chemical binding]; other site 633145002212 Q-loop/lid; other site 633145002213 ABC transporter signature motif; other site 633145002214 Walker B; other site 633145002215 D-loop; other site 633145002216 H-loop/switch region; other site 633145002217 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 633145002218 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 633145002219 Acyltransferase family; Region: Acyl_transf_3; cl19154 633145002220 threonine dehydratase; Reviewed; Region: PRK09224 633145002221 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 633145002222 FtsX-like permease family; Region: FtsX; pfam02687 633145002223 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 633145002224 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 633145002225 Walker A/P-loop; other site 633145002226 ATP binding site [chemical binding]; other site 633145002227 Q-loop/lid; other site 633145002228 ABC transporter signature motif; other site 633145002229 Walker B; other site 633145002230 D-loop; other site 633145002231 H-loop/switch region; other site 633145002232 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 633145002233 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 633145002234 FeS/SAM binding site; other site 633145002235 HemN C-terminal domain; Region: HemN_C; pfam06969 633145002236 GTP-binding protein LepA; Provisional; Region: PRK05433 633145002237 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 633145002238 G1 box; other site 633145002239 putative GEF interaction site [polypeptide binding]; other site 633145002240 GTP/Mg2+ binding site [chemical binding]; other site 633145002241 Switch I region; other site 633145002242 G2 box; other site 633145002243 G3 box; other site 633145002244 Switch II region; other site 633145002245 G4 box; other site 633145002246 G5 box; other site 633145002247 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 633145002248 Elongation Factor G, domain II; Region: EFG_II; pfam14492 633145002249 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 633145002250 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 633145002251 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651 633145002252 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 633145002253 NADH dehydrogenase; Region: NADHdh; cl00469 633145002254 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 633145002255 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 633145002256 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 633145002257 putative dimer interface [polypeptide binding]; other site 633145002258 [2Fe-2S] cluster binding site [ion binding]; other site 633145002259 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 633145002260 dimer interface [polypeptide binding]; other site 633145002261 [2Fe-2S] cluster binding site [ion binding]; other site 633145002262 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 633145002263 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 633145002264 SLBB domain; Region: SLBB; pfam10531 633145002265 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 633145002266 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 633145002267 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 633145002268 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 633145002269 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 633145002270 catalytic loop [active] 633145002271 iron binding site [ion binding]; other site 633145002272 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 633145002273 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 633145002274 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl19197 633145002275 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 633145002276 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 633145002277 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 633145002278 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 633145002279 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 633145002280 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 633145002281 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 633145002282 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 633145002283 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 633145002284 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 633145002285 motif 1; other site 633145002286 dimer interface [polypeptide binding]; other site 633145002287 active site 633145002288 motif 2; other site 633145002289 motif 3; other site 633145002290 elongation factor P; Validated; Region: PRK00529 633145002291 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 633145002292 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 633145002293 RNA binding site [nucleotide binding]; other site 633145002294 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 633145002295 RNA binding site [nucleotide binding]; other site 633145002296 Transcriptional regulators [Transcription]; Region: MarR; COG1846 633145002297 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 633145002298 Transport protein; Region: actII; TIGR00833 633145002299 MMPL family; Region: MMPL; cl14618 633145002300 MMPL family; Region: MMPL; cl14618 633145002301 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 633145002302 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 633145002303 non-specific DNA binding site [nucleotide binding]; other site 633145002304 salt bridge; other site 633145002305 sequence-specific DNA binding site [nucleotide binding]; other site 633145002306 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 633145002307 Catalytic site [active] 633145002308 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 633145002309 putative Zn2+ binding site [ion binding]; other site 633145002310 putative DNA binding site [nucleotide binding]; other site 633145002311 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 633145002312 Citrate transporter; Region: CitMHS; pfam03600 633145002313 transmembrane helices; other site 633145002314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633145002315 putative substrate translocation pore; other site 633145002316 Major Facilitator Superfamily; Region: MFS_1; pfam07690 633145002317 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 633145002318 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633145002319 active site 633145002320 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 633145002321 diiron binding motif [ion binding]; other site 633145002322 PAC2 family; Region: PAC2; pfam09754 633145002323 PAC2 family; Region: PAC2; pfam09754 633145002324 ATP-dependent DNA ligase; Provisional; Region: PRK01109 633145002325 hypothetical protein; Provisional; Region: PRK04334 633145002326 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 633145002327 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 633145002328 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 633145002329 Domain of unknown function DUF39; Region: DUF39; pfam01837 633145002330 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 633145002331 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633145002332 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 633145002333 Walker A motif; other site 633145002334 Walker A/P-loop; other site 633145002335 ATP binding site [chemical binding]; other site 633145002336 ATP binding site [chemical binding]; other site 633145002337 Walker B motif; other site 633145002338 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 633145002339 NADH dehydrogenase subunit B; Validated; Region: PRK06411 633145002340 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl19197 633145002341 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 633145002342 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 633145002343 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 633145002344 Ferredoxin [Energy production and conversion]; Region: COG1146 633145002345 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 633145002346 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 633145002347 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 633145002348 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 633145002349 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 633145002350 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 633145002351 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 633145002352 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 633145002353 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 633145002354 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 633145002355 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 633145002356 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 633145002357 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 633145002358 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 633145002359 active site 633145002360 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 633145002361 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 633145002362 minor groove reading motif; other site 633145002363 helix-hairpin-helix signature motif; other site 633145002364 substrate binding pocket [chemical binding]; other site 633145002365 active site 633145002366 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 633145002367 cobyric acid synthase; Provisional; Region: PRK00784 633145002368 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 633145002369 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 633145002370 catalytic triad [active] 633145002371 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 633145002372 CoenzymeA binding site [chemical binding]; other site 633145002373 subunit interaction site [polypeptide binding]; other site 633145002374 PHB binding site; other site 633145002375 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 633145002376 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 633145002377 Walker A/P-loop; other site 633145002378 ATP binding site [chemical binding]; other site 633145002379 Q-loop/lid; other site 633145002380 ABC transporter signature motif; other site 633145002381 Walker B; other site 633145002382 D-loop; other site 633145002383 H-loop/switch region; other site 633145002384 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 633145002385 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 633145002386 acyl-activating enzyme (AAE) consensus motif; other site 633145002387 active site 633145002388 AMP binding site [chemical binding]; other site 633145002389 CoA binding site [chemical binding]; other site 633145002390 AMP-binding enzyme C-terminal domain; Region: AMP-binding_C; cl17063 633145002391 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 633145002392 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 633145002393 Walker A/P-loop; other site 633145002394 ATP binding site [chemical binding]; other site 633145002395 Q-loop/lid; other site 633145002396 ABC transporter signature motif; other site 633145002397 Walker B; other site 633145002398 D-loop; other site 633145002399 H-loop/switch region; other site 633145002400 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 633145002401 ligand binding site [chemical binding]; other site 633145002402 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 633145002403 ligand binding site [chemical binding]; other site 633145002404 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 633145002405 TM-ABC transporter signature motif; other site 633145002406 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 633145002407 TM-ABC transporter signature motif; other site 633145002408 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 633145002409 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 633145002410 acyl-activating enzyme (AAE) consensus motif; other site 633145002411 putative AMP binding site [chemical binding]; other site 633145002412 putative active site [active] 633145002413 putative CoA binding site [chemical binding]; other site 633145002414 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 633145002415 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 633145002416 dimer interface [polypeptide binding]; other site 633145002417 PYR/PP interface [polypeptide binding]; other site 633145002418 TPP binding site [chemical binding]; other site 633145002419 substrate binding site [chemical binding]; other site 633145002420 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 633145002421 TPP-binding site; other site 633145002422 Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cl02553 633145002423 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 633145002424 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 633145002425 DNA polymerase II large subunit; Validated; Region: PRK04023 633145002426 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 633145002427 trimerization site [polypeptide binding]; other site 633145002428 active site 633145002429 Predicted membrane protein [Function unknown]; Region: COG3462 633145002430 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 633145002431 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 633145002432 metal-binding site [ion binding] 633145002433 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 633145002434 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 633145002435 metal-binding site [ion binding] 633145002436 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 633145002437 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633145002438 motif II; other site 633145002439 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 633145002440 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 633145002441 putative dimer interface [polypeptide binding]; other site 633145002442 Ferritin-like domain; Region: Ferritin; pfam00210 633145002443 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 633145002444 dinuclear metal binding motif [ion binding]; other site 633145002445 Ferritin-like domain; Region: Ferritin; pfam00210 633145002446 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 633145002447 dinuclear metal binding motif [ion binding]; other site 633145002448 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 633145002449 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 633145002450 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 633145002451 Smr domain; Region: Smr; pfam01713 633145002452 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 633145002453 substrate binding site [chemical binding]; other site 633145002454 glutamase interaction surface [polypeptide binding]; other site 633145002455 Repressor of nif and glnA expression [Transcription]; Region: COG1693 633145002456 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 633145002457 Domain of unknown function DUF128; Region: DUF128; pfam01995 633145002458 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 633145002459 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 633145002460 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 633145002461 FeS/SAM binding site; other site 633145002462 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 633145002463 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 633145002464 dimer interface [polypeptide binding]; other site 633145002465 active site 633145002466 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 633145002467 DHH family; Region: DHH; pfam01368 633145002468 DHHA1 domain; Region: DHHA1; pfam02272 633145002469 membrane protein; Provisional; Region: PRK14414 633145002470 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 633145002471 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 633145002472 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633145002473 ATP binding site [chemical binding]; other site 633145002474 putative Mg++ binding site [ion binding]; other site 633145002475 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633145002476 nucleotide binding region [chemical binding]; other site 633145002477 ATP-binding site [chemical binding]; other site 633145002478 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 633145002479 Protein of unknown function (DUF503); Region: DUF503; pfam04456 633145002480 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 633145002481 16S/18S rRNA binding site [nucleotide binding]; other site 633145002482 S13e-L30e interaction site [polypeptide binding]; other site 633145002483 25S rRNA binding site [nucleotide binding]; other site 633145002484 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 633145002485 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 633145002486 RNase E interface [polypeptide binding]; other site 633145002487 trimer interface [polypeptide binding]; other site 633145002488 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 633145002489 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 633145002490 RNase E interface [polypeptide binding]; other site 633145002491 trimer interface [polypeptide binding]; other site 633145002492 active site 633145002493 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 633145002494 putative nucleic acid binding region [nucleotide binding]; other site 633145002495 G-X-X-G motif; other site 633145002496 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 633145002497 RNA binding site [nucleotide binding]; other site 633145002498 domain interface; other site 633145002499 dihydrodipicolinate reductase; Provisional; Region: PRK00048 633145002500 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 633145002501 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 633145002502 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 633145002503 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 633145002504 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 633145002505 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 633145002506 dihydrodipicolinate synthase; Region: dapA; TIGR00674 633145002507 dimer interface [polypeptide binding]; other site 633145002508 active site 633145002509 catalytic residue [active] 633145002510 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 633145002511 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 633145002512 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 633145002513 Coenzyme A binding pocket [chemical binding]; other site 633145002514 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 633145002515 GDP-binding site [chemical binding]; other site 633145002516 ACT binding site; other site 633145002517 IMP binding site; other site 633145002518 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 633145002519 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 633145002520 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 633145002521 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 633145002522 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 633145002523 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 633145002524 RNA binding site [nucleotide binding]; other site 633145002525 active site 633145002526 Ribosome-binding factor A; Region: RBFA; pfam02033 633145002527 translation initiation factor IF-2; Region: IF-2; TIGR00487 633145002528 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 633145002529 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 633145002530 G1 box; other site 633145002531 putative GEF interaction site [polypeptide binding]; other site 633145002532 GTP/Mg2+ binding site [chemical binding]; other site 633145002533 Switch I region; other site 633145002534 G2 box; other site 633145002535 G3 box; other site 633145002536 Switch II region; other site 633145002537 G4 box; other site 633145002538 G5 box; other site 633145002539 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 633145002540 Translation-initiation factor 2; Region: IF-2; pfam11987 633145002541 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 633145002542 Protein of unknown function (DUF448); Region: DUF448; pfam04296 633145002543 putative RNA binding cleft [nucleotide binding]; other site 633145002544 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 633145002545 NusA N-terminal domain; Region: NusA_N; pfam08529 633145002546 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 633145002547 RNA binding site [nucleotide binding]; other site 633145002548 homodimer interface [polypeptide binding]; other site 633145002549 NusA-like KH domain; Region: KH_5; pfam13184 633145002550 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 633145002551 G-X-X-G motif; other site 633145002552 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 633145002553 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 633145002554 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633145002555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 633145002556 Walker A motif; other site 633145002557 ATP binding site [chemical binding]; other site 633145002558 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 633145002559 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 633145002560 Protein of unknown function (DUF502); Region: DUF502; cl01107 633145002561 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 633145002562 core dimer interface [polypeptide binding]; other site 633145002563 peripheral dimer interface [polypeptide binding]; other site 633145002564 L10 interface [polypeptide binding]; other site 633145002565 L11 interface [polypeptide binding]; other site 633145002566 putative EF-Tu interaction site [polypeptide binding]; other site 633145002567 putative EF-G interaction site [polypeptide binding]; other site 633145002568 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 633145002569 23S rRNA interface [nucleotide binding]; other site 633145002570 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 633145002571 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 633145002572 mRNA/rRNA interface [nucleotide binding]; other site 633145002573 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 633145002574 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 633145002575 23S rRNA interface [nucleotide binding]; other site 633145002576 L7/L12 interface [polypeptide binding]; other site 633145002577 putative thiostrepton binding site; other site 633145002578 L25 interface [polypeptide binding]; other site 633145002579 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 633145002580 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 633145002581 putative homodimer interface [polypeptide binding]; other site 633145002582 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 633145002583 heterodimer interface [polypeptide binding]; other site 633145002584 homodimer interface [polypeptide binding]; other site 633145002585 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 633145002586 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 633145002587 elongation factor Tu; Reviewed; Region: PRK00049 633145002588 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 633145002589 G1 box; other site 633145002590 GEF interaction site [polypeptide binding]; other site 633145002591 GTP/Mg2+ binding site [chemical binding]; other site 633145002592 Switch I region; other site 633145002593 G2 box; other site 633145002594 G3 box; other site 633145002595 Switch II region; other site 633145002596 G4 box; other site 633145002597 G5 box; other site 633145002598 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 633145002599 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 633145002600 Antibiotic Binding Site [chemical binding]; other site 633145002601 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 633145002602 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 633145002603 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 633145002604 putative ADP-binding pocket [chemical binding]; other site 633145002605 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 633145002606 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 633145002607 dimerization interface [polypeptide binding]; other site 633145002608 putative DNA binding site [nucleotide binding]; other site 633145002609 putative Zn2+ binding site [ion binding]; other site 633145002610 Predicted permease; Region: DUF318; cl17795 633145002611 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 633145002612 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 633145002613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633145002614 Major Facilitator Superfamily; Region: MFS_1; pfam07690 633145002615 putative substrate translocation pore; other site 633145002616 HPP family; Region: HPP; pfam04982 633145002617 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 633145002618 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 633145002619 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 633145002620 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 633145002621 acyl-activating enzyme (AAE) consensus motif; other site 633145002622 AMP binding site [chemical binding]; other site 633145002623 active site 633145002624 CoA binding site [chemical binding]; other site 633145002625 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145002626 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 633145002627 putative active site [active] 633145002628 heme pocket [chemical binding]; other site 633145002629 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145002630 putative active site [active] 633145002631 heme pocket [chemical binding]; other site 633145002632 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145002633 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 633145002634 putative active site [active] 633145002635 heme pocket [chemical binding]; other site 633145002636 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145002637 putative active site [active] 633145002638 heme pocket [chemical binding]; other site 633145002639 PAS domain S-box; Region: sensory_box; TIGR00229 633145002640 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145002641 putative active site [active] 633145002642 heme pocket [chemical binding]; other site 633145002643 PAS domain S-box; Region: sensory_box; TIGR00229 633145002644 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145002645 putative active site [active] 633145002646 heme pocket [chemical binding]; other site 633145002647 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 633145002648 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145002649 putative active site [active] 633145002650 heme pocket [chemical binding]; other site 633145002651 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 633145002652 dimer interface [polypeptide binding]; other site 633145002653 phosphorylation site [posttranslational modification] 633145002654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633145002655 ATP binding site [chemical binding]; other site 633145002656 Mg2+ binding site [ion binding]; other site 633145002657 G-X-G motif; other site 633145002658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633145002659 active site 633145002660 phosphorylation site [posttranslational modification] 633145002661 intermolecular recognition site; other site 633145002662 dimerization interface [polypeptide binding]; other site 633145002663 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 633145002664 ribonuclease III; Reviewed; Region: rnc; PRK00102 633145002665 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 633145002666 dimerization interface [polypeptide binding]; other site 633145002667 active site 633145002668 metal binding site [ion binding]; metal-binding site 633145002669 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 633145002670 dsRNA binding site [nucleotide binding]; other site 633145002671 acylphosphatase; Provisional; Region: PRK14450 633145002672 Domain of unknown function (DUF362); Region: DUF362; pfam04015 633145002673 multifunctional aminopeptidase A; Provisional; Region: PRK00913 633145002674 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 633145002675 interface (dimer of trimers) [polypeptide binding]; other site 633145002676 Substrate-binding/catalytic site; other site 633145002677 Zn-binding sites [ion binding]; other site 633145002678 AAA domain; Region: AAA_33; pfam13671 633145002679 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 633145002680 active site 633145002681 EDD domain protein, DegV family; Region: DegV; TIGR00762 633145002682 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 633145002683 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 633145002684 acyl-activating enzyme (AAE) consensus motif; other site 633145002685 active site 633145002686 AMP binding site [chemical binding]; other site 633145002687 CoA binding site [chemical binding]; other site 633145002688 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 633145002689 pyridoxal 5'-phosphate binding site [chemical binding]; other site 633145002690 catalytic residue [active] 633145002691 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 633145002692 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 633145002693 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 633145002694 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 633145002695 protein binding site [polypeptide binding]; other site 633145002696 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 633145002697 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 633145002698 active site 633145002699 HIGH motif; other site 633145002700 nucleotide binding site [chemical binding]; other site 633145002701 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 633145002702 active site 633145002703 KMSKS motif; other site 633145002704 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 633145002705 tRNA binding surface [nucleotide binding]; other site 633145002706 anticodon binding site; other site 633145002707 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 633145002708 Jag N-terminus; Region: Jag_N; pfam14804 633145002709 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 633145002710 G-X-X-G motif; other site 633145002711 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 633145002712 RxxxH motif; other site 633145002713 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 633145002714 PQQ-like domain; Region: PQQ_2; pfam13360 633145002715 beta-propeller repeat; Region: PQQ; smart00564 633145002716 PQQ-like domain; Region: PQQ_2; pfam13360 633145002717 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 633145002718 active site 633145002719 Trp docking motif [polypeptide binding]; other site 633145002720 Haemolytic domain; Region: Haemolytic; pfam01809 633145002721 Ribonuclease P; Region: Ribonuclease_P; pfam00825 633145002722 Ribosomal protein L34; Region: Ribosomal_L34; pfam00468 633145002723 30S ribosomal protein S18; Provisional; Region: PRK13400 633145002724 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 633145002725 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 633145002726 dimer interface [polypeptide binding]; other site 633145002727 ssDNA binding site [nucleotide binding]; other site 633145002728 tetramer (dimer of dimers) interface [polypeptide binding]; other site 633145002729 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 633145002730 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 633145002731 homotrimer interaction site [polypeptide binding]; other site 633145002732 putative active site [active] 633145002733 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 633145002734 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 633145002735 nucleotide binding site [chemical binding]; other site 633145002736 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 633145002737 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 633145002738 Walker A/P-loop; other site 633145002739 ATP binding site [chemical binding]; other site 633145002740 Q-loop/lid; other site 633145002741 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 633145002742 Q-loop/lid; other site 633145002743 ABC transporter signature motif; other site 633145002744 Walker B; other site 633145002745 D-loop; other site 633145002746 H-loop/switch region; other site 633145002747 EamA-like transporter family; Region: EamA; pfam00892 633145002748 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 633145002749 EamA-like transporter family; Region: EamA; pfam00892 633145002750 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 633145002751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633145002752 active site 633145002753 phosphorylation site [posttranslational modification] 633145002754 intermolecular recognition site; other site 633145002755 dimerization interface [polypeptide binding]; other site 633145002756 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 633145002757 DNA binding site [nucleotide binding] 633145002758 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 633145002759 dimerization interface [polypeptide binding]; other site 633145002760 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 633145002761 dimer interface [polypeptide binding]; other site 633145002762 phosphorylation site [posttranslational modification] 633145002763 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633145002764 ATP binding site [chemical binding]; other site 633145002765 Mg2+ binding site [ion binding]; other site 633145002766 G-X-G motif; other site 633145002767 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 633145002768 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 633145002769 Walker A/P-loop; other site 633145002770 ATP binding site [chemical binding]; other site 633145002771 Q-loop/lid; other site 633145002772 ABC transporter signature motif; other site 633145002773 Walker B; other site 633145002774 D-loop; other site 633145002775 H-loop/switch region; other site 633145002776 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 633145002777 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 633145002778 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 633145002779 Walker A/P-loop; other site 633145002780 ATP binding site [chemical binding]; other site 633145002781 Q-loop/lid; other site 633145002782 ABC transporter signature motif; other site 633145002783 Walker B; other site 633145002784 D-loop; other site 633145002785 H-loop/switch region; other site 633145002786 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 633145002787 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 633145002788 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 633145002789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633145002790 dimer interface [polypeptide binding]; other site 633145002791 conserved gate region; other site 633145002792 putative PBP binding loops; other site 633145002793 ABC-ATPase subunit interface; other site 633145002794 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 633145002795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633145002796 dimer interface [polypeptide binding]; other site 633145002797 conserved gate region; other site 633145002798 putative PBP binding loops; other site 633145002799 ABC-ATPase subunit interface; other site 633145002800 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 633145002801 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 633145002802 peptide binding site [polypeptide binding]; other site 633145002803 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 633145002804 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 633145002805 Beta-Casp domain; Region: Beta-Casp; smart01027 633145002806 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 633145002807 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 633145002808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633145002809 active site 633145002810 phosphorylation site [posttranslational modification] 633145002811 intermolecular recognition site; other site 633145002812 dimerization interface [polypeptide binding]; other site 633145002813 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 633145002814 DNA binding residues [nucleotide binding] 633145002815 dimerization interface [polypeptide binding]; other site 633145002816 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145002817 PAS domain; Region: PAS_9; pfam13426 633145002818 putative active site [active] 633145002819 heme pocket [chemical binding]; other site 633145002820 PAS fold; Region: PAS_4; pfam08448 633145002821 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145002822 putative active site [active] 633145002823 heme pocket [chemical binding]; other site 633145002824 GAF domain; Region: GAF_2; pfam13185 633145002825 PAS domain S-box; Region: sensory_box; TIGR00229 633145002826 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145002827 putative active site [active] 633145002828 heme pocket [chemical binding]; other site 633145002829 PAS domain; Region: PAS; smart00091 633145002830 PAS domain; Region: PAS_9; pfam13426 633145002831 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 633145002832 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145002833 putative active site [active] 633145002834 heme pocket [chemical binding]; other site 633145002835 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145002836 putative active site [active] 633145002837 heme pocket [chemical binding]; other site 633145002838 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 633145002839 Histidine kinase; Region: HisKA_3; pfam07730 633145002840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633145002841 ATP binding site [chemical binding]; other site 633145002842 Mg2+ binding site [ion binding]; other site 633145002843 G-X-G motif; other site 633145002844 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 633145002845 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633145002846 S-adenosylmethionine binding site [chemical binding]; other site 633145002847 Carbonic anhydrase; Region: Pro_CA; smart00947 633145002848 active site clefts [active] 633145002849 zinc binding site [ion binding]; other site 633145002850 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 633145002851 active site 633145002852 dimer interface [polypeptide binding]; other site 633145002853 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 633145002854 NAD synthetase; Provisional; Region: PRK13981 633145002855 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 633145002856 multimer interface [polypeptide binding]; other site 633145002857 active site 633145002858 catalytic triad [active] 633145002859 protein interface 1 [polypeptide binding]; other site 633145002860 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 633145002861 homodimer interface [polypeptide binding]; other site 633145002862 NAD binding pocket [chemical binding]; other site 633145002863 ATP binding pocket [chemical binding]; other site 633145002864 Mg binding site [ion binding]; other site 633145002865 active-site loop [active] 633145002866 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 633145002867 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 633145002868 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 633145002869 Nitrogen regulatory protein P-II; Region: P-II; smart00938 633145002870 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 633145002871 transcriptional regulator PhoB; Provisional; Region: PRK10161 633145002872 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 633145002873 DNA binding site [nucleotide binding] 633145002874 Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981 633145002875 putative subunit interface; other site 633145002876 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 633145002877 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 633145002878 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 633145002879 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 633145002880 active site 633145002881 FMN binding site [chemical binding]; other site 633145002882 substrate binding site [chemical binding]; other site 633145002883 3Fe-4S cluster binding site [ion binding]; other site 633145002884 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 633145002885 substrate binding site [chemical binding]; other site 633145002886 glutamase interaction surface [polypeptide binding]; other site 633145002887 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 633145002888 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 633145002889 putative active site [active] 633145002890 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 633145002891 active site 633145002892 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 633145002893 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 633145002894 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 633145002895 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 633145002896 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 633145002897 putative active site [active] 633145002898 oxyanion strand; other site 633145002899 catalytic triad [active] 633145002900 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 633145002901 Predicted membrane protein [Function unknown]; Region: COG1971 633145002902 Domain of unknown function DUF; Region: DUF204; pfam02659 633145002903 Domain of unknown function DUF; Region: DUF204; pfam02659 633145002904 cysteine synthase; Region: PLN02565 633145002905 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 633145002906 dimer interface [polypeptide binding]; other site 633145002907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 633145002908 catalytic residue [active] 633145002909 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 633145002910 FeS/SAM binding site; other site 633145002911 Radical SAM superfamily; Region: Radical_SAM; pfam04055 633145002912 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 633145002913 Transposase; Region: HTH_Tnp_1; cl17663 633145002914 putative transposase OrfB; Reviewed; Region: PHA02517 633145002915 HTH-like domain; Region: HTH_21; pfam13276 633145002916 Integrase core domain; Region: rve; pfam00665 633145002917 Integrase core domain; Region: rve_3; pfam13683 633145002918 BioY family; Region: BioY; pfam02632 633145002919 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cd01342 633145002920 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 633145002921 homopentamer interface [polypeptide binding]; other site 633145002922 active site 633145002923 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 633145002924 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 633145002925 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 633145002926 dimerization interface [polypeptide binding]; other site 633145002927 active site 633145002928 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 633145002929 Lumazine binding domain; Region: Lum_binding; pfam00677 633145002930 Lumazine binding domain; Region: Lum_binding; pfam00677 633145002931 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 633145002932 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 633145002933 catalytic motif [active] 633145002934 Zn binding site [ion binding]; other site 633145002935 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 633145002936 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 633145002937 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 633145002938 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 633145002939 Catalytic site [active] 633145002940 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633145002941 active site 633145002942 Endonuclease related to archaeal Holliday junction resolvase; Region: Endonuc_Holl; pfam10107 633145002943 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 633145002944 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633145002945 ATP binding site [chemical binding]; other site 633145002946 Mg2+ binding site [ion binding]; other site 633145002947 G-X-G motif; other site 633145002948 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 633145002949 ATP binding site [chemical binding]; other site 633145002950 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 633145002951 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 633145002952 Part of AAA domain; Region: AAA_19; pfam13245 633145002953 AAA domain; Region: AAA_12; pfam13087 633145002954 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 633145002955 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 633145002956 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633145002957 active site 633145002958 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 633145002959 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 633145002960 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 633145002961 dihydroorotase; Validated; Region: pyrC; PRK09357 633145002962 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 633145002963 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 633145002964 active site 633145002965 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 633145002966 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 633145002967 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 633145002968 catalytic site [active] 633145002969 subunit interface [polypeptide binding]; other site 633145002970 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 633145002971 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 633145002972 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 633145002973 Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787 633145002974 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 633145002975 ATP-grasp domain; Region: ATP-grasp_4; cl17255 633145002976 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 633145002977 IMP binding site; other site 633145002978 dimer interface [polypeptide binding]; other site 633145002979 interdomain contacts; other site 633145002980 partial ornithine binding site; other site 633145002981 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 633145002982 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 633145002983 FAD binding pocket [chemical binding]; other site 633145002984 FAD binding motif [chemical binding]; other site 633145002985 phosphate binding motif [ion binding]; other site 633145002986 beta-alpha-beta structure motif; other site 633145002987 NAD binding pocket [chemical binding]; other site 633145002988 Iron coordination center [ion binding]; other site 633145002989 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 633145002990 active site 633145002991 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 633145002992 homodimer interface [polypeptide binding]; other site 633145002993 pyridoxal 5'-phosphate binding site [chemical binding]; other site 633145002994 catalytic residue [active] 633145002995 homoserine dehydrogenase; Provisional; Region: PRK06349 633145002996 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 633145002997 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 633145002998 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 633145002999 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 633145003000 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 633145003001 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 633145003002 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 633145003003 active site 633145003004 Substrate binding site; other site 633145003005 Mg++ binding site; other site 633145003006 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 633145003007 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 633145003008 acetyl-CoA synthetase; Provisional; Region: PRK00174 633145003009 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 633145003010 active site 633145003011 CoA binding site [chemical binding]; other site 633145003012 acyl-activating enzyme (AAE) consensus motif; other site 633145003013 AMP binding site [chemical binding]; other site 633145003014 acetate binding site [chemical binding]; other site 633145003015 peptide chain release factor 1; Validated; Region: prfA; PRK00591 633145003016 PCRF domain; Region: PCRF; pfam03462 633145003017 RF-1 domain; Region: RF-1; pfam00472 633145003018 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 633145003019 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633145003020 S-adenosylmethionine binding site [chemical binding]; other site 633145003021 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 633145003022 elongation factor G; Reviewed; Region: PRK12740 633145003023 G1 box; other site 633145003024 putative GEF interaction site [polypeptide binding]; other site 633145003025 GTP/Mg2+ binding site [chemical binding]; other site 633145003026 Switch I region; other site 633145003027 G2 box; other site 633145003028 G3 box; other site 633145003029 Switch II region; other site 633145003030 G4 box; other site 633145003031 G5 box; other site 633145003032 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 633145003033 Elongation Factor G, domain II; Region: EFG_II; pfam14492 633145003034 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 633145003035 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 633145003036 Integral membrane protein DUF95; Region: DUF95; pfam01944 633145003037 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 633145003038 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 633145003039 active site 633145003040 Int/Topo IB signature motif; other site 633145003041 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 633145003042 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 633145003043 GIY-YIG motif/motif A; other site 633145003044 active site 633145003045 catalytic site [active] 633145003046 putative DNA binding site [nucleotide binding]; other site 633145003047 metal binding site [ion binding]; metal-binding site 633145003048 UvrB/uvrC motif; Region: UVR; pfam02151 633145003049 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 633145003050 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 633145003051 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 633145003052 Coenzyme A binding pocket [chemical binding]; other site 633145003053 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633145003054 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 633145003055 active site 633145003056 motif I; other site 633145003057 motif II; other site 633145003058 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 633145003059 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 633145003060 MutS domain I; Region: MutS_I; pfam01624 633145003061 MutS domain II; Region: MutS_II; pfam05188 633145003062 MutS domain III; Region: MutS_III; pfam05192 633145003063 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 633145003064 Walker A/P-loop; other site 633145003065 ATP binding site [chemical binding]; other site 633145003066 Q-loop/lid; other site 633145003067 ABC transporter signature motif; other site 633145003068 Walker B; other site 633145003069 D-loop; other site 633145003070 H-loop/switch region; other site 633145003071 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 633145003072 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 633145003073 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 633145003074 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 633145003075 Fructose-1,6-bisphosphatase; Region: FBPase_3; pfam01950 633145003076 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 633145003077 active site 633145003078 dimerization interface [polypeptide binding]; other site 633145003079 DNA polymerase III subunit beta; Validated; Region: PRK05643 633145003080 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 633145003081 putative DNA binding surface [nucleotide binding]; other site 633145003082 dimer interface [polypeptide binding]; other site 633145003083 beta-clamp/clamp loader binding surface; other site 633145003084 beta-clamp/translesion DNA polymerase binding surface; other site 633145003085 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 633145003086 Domain of unknown function (DU1801); Region: DUF1801; cl17490 633145003087 Putative lysophospholipase; Region: Hydrolase_4; cl19140 633145003088 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 633145003089 Smr domain; Region: Smr; pfam01713 633145003090 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 633145003091 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 633145003092 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 633145003093 putative active site [active] 633145003094 putative substrate binding site [chemical binding]; other site 633145003095 putative cosubstrate binding site; other site 633145003096 catalytic site [active] 633145003097 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 633145003098 active site 633145003099 arsenical-resistance protein; Region: acr3; TIGR00832 633145003100 methionine sulfoxide reductase A; Provisional; Region: PRK14054 633145003101 methionine sulfoxide reductase B; Provisional; Region: PRK05508 633145003102 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 633145003103 TfoX N-terminal domain; Region: TfoX_N; pfam04993 633145003104 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 633145003105 dimerization interface [polypeptide binding]; other site 633145003106 putative DNA binding site [nucleotide binding]; other site 633145003107 putative Zn2+ binding site [ion binding]; other site 633145003108 Predicted integral membrane protein [Function unknown]; Region: COG5658 633145003109 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 633145003110 SdpI/YhfL protein family; Region: SdpI; pfam13630 633145003111 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 633145003112 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 633145003113 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 633145003114 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 633145003115 Walker A motif; other site 633145003116 ATP binding site [chemical binding]; other site 633145003117 Walker B motif; other site 633145003118 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 633145003119 heterotetramer interface [polypeptide binding]; other site 633145003120 active site pocket [active] 633145003121 cleavage site 633145003122 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 633145003123 nucleotide binding site [chemical binding]; other site 633145003124 N-acetyl-L-glutamate binding site [chemical binding]; other site 633145003125 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 633145003126 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 633145003127 inhibitor-cofactor binding pocket; inhibition site 633145003128 pyridoxal 5'-phosphate binding site [chemical binding]; other site 633145003129 catalytic residue [active] 633145003130 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 633145003131 ANP binding site [chemical binding]; other site 633145003132 Substrate Binding Site II [chemical binding]; other site 633145003133 Substrate Binding Site I [chemical binding]; other site 633145003134 argininosuccinate lyase; Provisional; Region: PRK00855 633145003135 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 633145003136 active sites [active] 633145003137 tetramer interface [polypeptide binding]; other site 633145003138 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 633145003139 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 633145003140 DAK2 domain; Region: Dak2; pfam02734 633145003141 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 633145003142 EDD domain protein, DegV family; Region: DegV; TIGR00762 633145003143 EDD domain protein, DegV family; Region: DegV; TIGR00762 633145003144 EDD domain protein, DegV family; Region: DegV; TIGR00762 633145003145 EDD domain protein, DegV family; Region: DegV; TIGR00762 633145003146 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 633145003147 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 633145003148 generic binding surface II; other site 633145003149 ssDNA binding site; other site 633145003150 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633145003151 ATP binding site [chemical binding]; other site 633145003152 putative Mg++ binding site [ion binding]; other site 633145003153 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633145003154 nucleotide binding region [chemical binding]; other site 633145003155 ATP-binding site [chemical binding]; other site 633145003156 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 633145003157 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 633145003158 Zn2+ binding site [ion binding]; other site 633145003159 Mg2+ binding site [ion binding]; other site 633145003160 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 633145003161 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 633145003162 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 633145003163 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 633145003164 active site 633145003165 HIGH motif; other site 633145003166 KMSK motif region; other site 633145003167 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 633145003168 tRNA binding surface [nucleotide binding]; other site 633145003169 anticodon binding site; other site 633145003170 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 633145003171 AsnC family; Region: AsnC_trans_reg; pfam01037 633145003172 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 633145003173 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 633145003174 NAD binding site [chemical binding]; other site 633145003175 homotetramer interface [polypeptide binding]; other site 633145003176 homodimer interface [polypeptide binding]; other site 633145003177 substrate binding site [chemical binding]; other site 633145003178 active site 633145003179 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 633145003180 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 633145003181 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 633145003182 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 633145003183 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 633145003184 NAD(P) binding site [chemical binding]; other site 633145003185 homotetramer interface [polypeptide binding]; other site 633145003186 homodimer interface [polypeptide binding]; other site 633145003187 active site 633145003188 transcription antitermination factor NusB; Region: nusB; TIGR01951 633145003189 putative RNA binding site [nucleotide binding]; other site 633145003190 acyl carrier protein; Provisional; Region: acpP; PRK00982 633145003191 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 633145003192 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 633145003193 B12 binding site [chemical binding]; other site 633145003194 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 633145003195 FeS/SAM binding site; other site 633145003196 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 633145003197 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 633145003198 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 633145003199 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 633145003200 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633145003201 ATP binding site [chemical binding]; other site 633145003202 putative Mg++ binding site [ion binding]; other site 633145003203 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633145003204 nucleotide binding region [chemical binding]; other site 633145003205 ATP-binding site [chemical binding]; other site 633145003206 TRCF domain; Region: TRCF; pfam03461 633145003207 gamma-glutamyl kinase; Provisional; Region: PRK05429 633145003208 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 633145003209 nucleotide binding site [chemical binding]; other site 633145003210 homotetrameric interface [polypeptide binding]; other site 633145003211 putative phosphate binding site [ion binding]; other site 633145003212 putative allosteric binding site; other site 633145003213 PUA domain; Region: PUA; pfam01472 633145003214 FlxA-like protein; Region: FlxA; pfam14282 633145003215 Trypsin; Region: Trypsin; pfam00089 633145003216 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 633145003217 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 633145003218 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 633145003219 DNA binding residues [nucleotide binding] 633145003220 dimer interface [polypeptide binding]; other site 633145003221 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 633145003222 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 633145003223 putative catalytic cysteine [active] 633145003224 ribonuclease PH; Reviewed; Region: rph; PRK00173 633145003225 Ribonuclease PH; Region: RNase_PH_bact; cd11362 633145003226 hexamer interface [polypeptide binding]; other site 633145003227 active site 633145003228 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 633145003229 nudix motif; other site 633145003230 Competence-damaged protein; Region: CinA; pfam02464 633145003231 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 633145003232 PAS domain S-box; Region: sensory_box; TIGR00229 633145003233 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 633145003234 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 633145003235 dimer interface [polypeptide binding]; other site 633145003236 phosphorylation site [posttranslational modification] 633145003237 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633145003238 ATP binding site [chemical binding]; other site 633145003239 Mg2+ binding site [ion binding]; other site 633145003240 G-X-G motif; other site 633145003241 Helix-turn-helix domain; Region: HTH_17; pfam12728 633145003242 Response regulator receiver domain; Region: Response_reg; pfam00072 633145003243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633145003244 active site 633145003245 phosphorylation site [posttranslational modification] 633145003246 intermolecular recognition site; other site 633145003247 dimerization interface [polypeptide binding]; other site 633145003248 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 633145003249 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 633145003250 Probable zinc-binding domain; Region: zf-trcl; pfam13451 633145003251 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 633145003252 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 633145003253 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 633145003254 G1 box; other site 633145003255 putative GEF interaction site [polypeptide binding]; other site 633145003256 GTP/Mg2+ binding site [chemical binding]; other site 633145003257 Switch I region; other site 633145003258 G2 box; other site 633145003259 G3 box; other site 633145003260 Switch II region; other site 633145003261 G4 box; other site 633145003262 G5 box; other site 633145003263 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 633145003264 Elongation Factor G, domain II; Region: EFG_II; pfam14492 633145003265 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 633145003266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633145003267 metabolite-proton symporter; Region: 2A0106; TIGR00883 633145003268 putative substrate translocation pore; other site 633145003269 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 633145003270 Ligand Binding Site [chemical binding]; other site 633145003271 Protein of unknown function (DUF502); Region: DUF502; cl01107 633145003272 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 633145003273 Fasciclin domain; Region: Fasciclin; pfam02469 633145003274 Glycosyl transferase 4-like; Region: Glyco_trans_4_2; pfam13477 633145003275 Uncharacterized conserved protein [Function unknown]; Region: COG3422 633145003276 Putative lysophospholipase; Region: Hydrolase_4; cl19140 633145003277 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 633145003278 Putative lysophospholipase; Region: Hydrolase_4; cl19140 633145003279 recombination factor protein RarA; Reviewed; Region: PRK13342 633145003280 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633145003281 Walker A motif; other site 633145003282 ATP binding site [chemical binding]; other site 633145003283 Walker B motif; other site 633145003284 arginine finger; other site 633145003285 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 633145003286 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 633145003287 putative ligand binding pocket/active site [active] 633145003288 putative metal binding site [ion binding]; other site 633145003289 AMMECR1; Region: AMMECR1; pfam01871 633145003290 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 633145003291 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 633145003292 FeS/SAM binding site; other site 633145003293 EamA-like transporter family; Region: EamA; pfam00892 633145003294 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 633145003295 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 633145003296 Renin receptor-like protein; Region: Renin_r; pfam07850 633145003297 YcxB-like protein; Region: YcxB; pfam14317 633145003298 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633145003299 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 633145003300 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 633145003301 Walker A/P-loop; other site 633145003302 Walker A/P-loop; other site 633145003303 ATP binding site [chemical binding]; other site 633145003304 ATP binding site [chemical binding]; other site 633145003305 Q-loop/lid; other site 633145003306 ABC transporter signature motif; other site 633145003307 Walker B; other site 633145003308 D-loop; other site 633145003309 H-loop/switch region; other site 633145003310 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 633145003311 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 633145003312 Coenzyme A binding pocket [chemical binding]; other site 633145003313 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 633145003314 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 633145003315 CoA-binding site [chemical binding]; other site 633145003316 ATP-binding [chemical binding]; other site 633145003317 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 633145003318 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633145003319 NAD(P) binding site [chemical binding]; other site 633145003320 active site 633145003321 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 633145003322 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 633145003323 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 633145003324 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 633145003325 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 633145003326 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 633145003327 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 633145003328 Coenzyme A binding pocket [chemical binding]; other site 633145003329 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 633145003330 catalytic residues [active] 633145003331 Protein of unknown function (DUF2769); Region: DUF2769; pfam10967 633145003332 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 633145003333 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 633145003334 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 633145003335 Predicted membrane protein (DUF2178); Region: DUF2178; pfam09946 633145003336 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 633145003337 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 633145003338 non-specific DNA binding site [nucleotide binding]; other site 633145003339 salt bridge; other site 633145003340 sequence-specific DNA binding site [nucleotide binding]; other site 633145003341 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 633145003342 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633145003343 Walker A/P-loop; other site 633145003344 ATP binding site [chemical binding]; other site 633145003345 Q-loop/lid; other site 633145003346 ABC transporter signature motif; other site 633145003347 Walker B; other site 633145003348 D-loop; other site 633145003349 H-loop/switch region; other site 633145003350 Acyltransferase family; Region: Acyl_transf_3; cl19154 633145003351 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 633145003352 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 633145003353 aspartate aminotransferase; Provisional; Region: PRK05764 633145003354 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 633145003355 pyridoxal 5'-phosphate binding site [chemical binding]; other site 633145003356 homodimer interface [polypeptide binding]; other site 633145003357 catalytic residue [active] 633145003358 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 633145003359 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 633145003360 active site 633145003361 HIGH motif; other site 633145003362 dimer interface [polypeptide binding]; other site 633145003363 KMSKS motif; other site 633145003364 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 633145003365 Fe-S cluster binding site [ion binding]; other site 633145003366 substrate binding site [chemical binding]; other site 633145003367 catalytic site [active] 633145003368 Class I aldolases; Region: Aldolase_Class_I; cl17187 633145003369 RDD family; Region: RDD; pfam06271 633145003370 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 633145003371 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 633145003372 active site 633145003373 HIGH motif; other site 633145003374 KMSKS motif; other site 633145003375 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 633145003376 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 633145003377 FeS/SAM binding site; other site 633145003378 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 633145003379 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 633145003380 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 633145003381 heterodimer interface [polypeptide binding]; other site 633145003382 active site 633145003383 FMN binding site [chemical binding]; other site 633145003384 homodimer interface [polypeptide binding]; other site 633145003385 substrate binding site [chemical binding]; other site 633145003386 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 633145003387 lipoprotein signal peptidase; Provisional; Region: PRK14784 633145003388 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 633145003389 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 633145003390 RNA binding surface [nucleotide binding]; other site 633145003391 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 633145003392 active site 633145003393 Winged helix-turn-helix; Region: HTH_45; pfam14947 633145003394 Phospholipid methyltransferase; Region: PEMT; cl17370 633145003395 GH3 auxin-responsive promoter; Region: GH3; pfam03321 633145003396 indole-3-acetic acid-amido synthetase; Region: PLN02249 633145003397 GAF domain; Region: GAF_2; pfam13185 633145003398 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 633145003399 metal binding site [ion binding]; metal-binding site 633145003400 active site 633145003401 I-site; other site 633145003402 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 633145003403 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 633145003404 Zn2+ binding site [ion binding]; other site 633145003405 Mg2+ binding site [ion binding]; other site 633145003406 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 633145003407 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 633145003408 dimerization interface [polypeptide binding]; other site 633145003409 active site 633145003410 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 633145003411 L-aspartate oxidase; Provisional; Region: PRK06175 633145003412 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 633145003413 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 633145003414 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14336 633145003415 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 633145003416 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 633145003417 FeS/SAM binding site; other site 633145003418 TRAM domain; Region: TRAM; pfam01938 633145003419 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 633145003420 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 633145003421 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 633145003422 DNA binding site [nucleotide binding] 633145003423 catalytic residue [active] 633145003424 H2TH interface [polypeptide binding]; other site 633145003425 putative catalytic residues [active] 633145003426 turnover-facilitating residue; other site 633145003427 intercalation triad [nucleotide binding]; other site 633145003428 8OG recognition residue [nucleotide binding]; other site 633145003429 putative reading head residues; other site 633145003430 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 633145003431 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 633145003432 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 633145003433 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 633145003434 active site 633145003435 DNA polymerase I; Provisional; Region: PRK05755 633145003436 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 633145003437 active site 633145003438 metal binding site 1 [ion binding]; metal-binding site 633145003439 putative 5' ssDNA interaction site; other site 633145003440 metal binding site 3; metal-binding site 633145003441 metal binding site 2 [ion binding]; metal-binding site 633145003442 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 633145003443 putative DNA binding site [nucleotide binding]; other site 633145003444 putative metal binding site [ion binding]; other site 633145003445 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 633145003446 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 633145003447 active site 633145003448 DNA binding site [nucleotide binding] 633145003449 catalytic site [active] 633145003450 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 633145003451 active site residue [active] 633145003452 ornithine carbamoyltransferase; Provisional; Region: PRK00779 633145003453 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 633145003454 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 633145003455 GTP-binding protein Der; Reviewed; Region: PRK00093 633145003456 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 633145003457 G1 box; other site 633145003458 GTP/Mg2+ binding site [chemical binding]; other site 633145003459 Switch I region; other site 633145003460 G2 box; other site 633145003461 Switch II region; other site 633145003462 G3 box; other site 633145003463 G4 box; other site 633145003464 G5 box; other site 633145003465 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 633145003466 G1 box; other site 633145003467 GTP/Mg2+ binding site [chemical binding]; other site 633145003468 Switch I region; other site 633145003469 G2 box; other site 633145003470 G3 box; other site 633145003471 Switch II region; other site 633145003472 G4 box; other site 633145003473 G5 box; other site 633145003474 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 633145003475 membrane protein; Provisional; Region: PRK14415 633145003476 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 633145003477 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 633145003478 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 633145003479 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 633145003480 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 633145003481 HSP70 interaction site [polypeptide binding]; other site 633145003482 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 633145003483 substrate binding site [polypeptide binding]; other site 633145003484 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 633145003485 Zn binding sites [ion binding]; other site 633145003486 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 633145003487 dimer interface [polypeptide binding]; other site 633145003488 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 633145003489 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 633145003490 nucleotide binding site [chemical binding]; other site 633145003491 NEF interaction site [polypeptide binding]; other site 633145003492 SBD interface [polypeptide binding]; other site 633145003493 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 633145003494 dimer interface [polypeptide binding]; other site 633145003495 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 633145003496 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 633145003497 HrcA protein C terminal domain; Region: HrcA; pfam01628 633145003498 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 633145003499 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 633145003500 Caspase domain; Region: Peptidase_C14; pfam00656 633145003501 Peptidase C13 family; Region: Peptidase_C13; cl02159 633145003502 RNase_H superfamily; Region: RNase_H_2; pfam13482 633145003503 active site 633145003504 catalytic site [active] 633145003505 substrate binding site [chemical binding]; other site 633145003506 active site 633145003507 substrate binding site [chemical binding]; other site 633145003508 catalytic site [active] 633145003509 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 633145003510 transcription termination factor Rho; Provisional; Region: rho; PRK09376 633145003511 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 633145003512 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 633145003513 RNA binding site [nucleotide binding]; other site 633145003514 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 633145003515 Walker A motif; other site 633145003516 ATP binding site [chemical binding]; other site 633145003517 Walker B motif; other site 633145003518 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 633145003519 active site 633145003520 intersubunit interactions; other site 633145003521 catalytic residue [active] 633145003522 CTP synthetase; Validated; Region: pyrG; PRK05380 633145003523 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 633145003524 Catalytic site [active] 633145003525 active site 633145003526 UTP binding site [chemical binding]; other site 633145003527 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 633145003528 active site 633145003529 putative oxyanion hole; other site 633145003530 catalytic triad [active] 633145003531 chaperone protein DnaJ; Provisional; Region: PRK10767 633145003532 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 633145003533 HSP70 interaction site [polypeptide binding]; other site 633145003534 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 633145003535 substrate binding site [polypeptide binding]; other site 633145003536 dimer interface [polypeptide binding]; other site 633145003537 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 633145003538 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 633145003539 DNA binding residues [nucleotide binding] 633145003540 putative dimer interface [polypeptide binding]; other site 633145003541 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 633145003542 Clp amino terminal domain; Region: Clp_N; pfam02861 633145003543 Clp amino terminal domain; Region: Clp_N; pfam02861 633145003544 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633145003545 Walker A motif; other site 633145003546 ATP binding site [chemical binding]; other site 633145003547 Walker B motif; other site 633145003548 arginine finger; other site 633145003549 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633145003550 Walker A motif; other site 633145003551 ATP binding site [chemical binding]; other site 633145003552 Walker B motif; other site 633145003553 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 633145003554 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 633145003555 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 633145003556 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 633145003557 active site 633145003558 tetramer interface [polypeptide binding]; other site 633145003559 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633145003560 active site 633145003561 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 633145003562 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 633145003563 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 633145003564 dimerization interface [polypeptide binding]; other site 633145003565 putative ATP binding site [chemical binding]; other site 633145003566 Methyltransferase domain; Region: Methyltransf_31; pfam13847 633145003567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633145003568 S-adenosylmethionine binding site [chemical binding]; other site 633145003569 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 633145003570 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 633145003571 purine monophosphate binding site [chemical binding]; other site 633145003572 dimer interface [polypeptide binding]; other site 633145003573 putative catalytic residues [active] 633145003574 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 633145003575 nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662 633145003576 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 633145003577 active site 633145003578 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 633145003579 arsenite S-adenosylmethyltransferase; Reviewed; Region: arsM; PRK11873 633145003580 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633145003581 S-adenosylmethionine binding site [chemical binding]; other site 633145003582 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 633145003583 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 633145003584 Ligand Binding Site [chemical binding]; other site 633145003585 TilS substrate C-terminal domain; Region: TilS_C; smart00977 633145003586 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 633145003587 catalytic core [active] 633145003588 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 633145003589 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 633145003590 Domain of unknown function DUF21; Region: DUF21; pfam01595 633145003591 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 633145003592 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 633145003593 Transporter associated domain; Region: CorC_HlyC; pfam03471 633145003594 UGMP family protein; Validated; Region: PRK09604 633145003595 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 633145003596 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 633145003597 oligomerisation interface [polypeptide binding]; other site 633145003598 mobile loop; other site 633145003599 roof hairpin; other site 633145003600 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 633145003601 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 633145003602 ring oligomerisation interface [polypeptide binding]; other site 633145003603 ATP/Mg binding site [chemical binding]; other site 633145003604 stacking interactions; other site 633145003605 hinge regions; other site 633145003606 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 633145003607 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 633145003608 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 633145003609 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 633145003610 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 633145003611 Acylphosphatase; Region: Acylphosphatase; pfam00708 633145003612 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 633145003613 HypF finger; Region: zf-HYPF; pfam07503 633145003614 HypF finger; Region: zf-HYPF; pfam07503 633145003615 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 633145003616 HupF/HypC family; Region: HupF_HypC; pfam01455 633145003617 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 633145003618 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 633145003619 dimerization interface [polypeptide binding]; other site 633145003620 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 633145003621 ATP binding site [chemical binding]; other site 633145003622 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 633145003623 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 633145003624 glyceraldehyde-3-phosphate dehydrogenase B; Region: PLN02237 633145003625 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 633145003626 DNA binding residues [nucleotide binding] 633145003627 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 633145003628 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824 633145003629 putative hydrophobic ligand binding site [chemical binding]; other site 633145003630 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 633145003631 putative active site pocket [active] 633145003632 dimerization interface [polypeptide binding]; other site 633145003633 putative catalytic residue [active] 633145003634 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 633145003635 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 633145003636 5S rRNA interface [nucleotide binding]; other site 633145003637 CTC domain interface [polypeptide binding]; other site 633145003638 L16 interface [polypeptide binding]; other site 633145003639 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 633145003640 Amidohydrolase; Region: Amidohydro_2; pfam04909 633145003641 active site 633145003642 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 633145003643 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 633145003644 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 633145003645 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 633145003646 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633145003647 active site 633145003648 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 633145003649 30S subunit binding site; other site 633145003650 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 633145003651 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 633145003652 DNA binding site [nucleotide binding] 633145003653 active site 633145003654 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 633145003655 hypothetical protein; Reviewed; Region: PRK00024 633145003656 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 633145003657 helix-hairpin-helix signature motif; other site 633145003658 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 633145003659 MPN+ (JAMM) motif; other site 633145003660 Zinc-binding site [ion binding]; other site 633145003661 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 633145003662 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 633145003663 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 633145003664 active site 633145003665 PHP Thumb interface [polypeptide binding]; other site 633145003666 metal binding site [ion binding]; metal-binding site 633145003667 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 633145003668 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 633145003669 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 633145003670 generic binding surface II; other site 633145003671 generic binding surface I; other site 633145003672 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 633145003673 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 633145003674 anthranilate synthase component I; Provisional; Region: PRK13565 633145003675 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 633145003676 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 633145003677 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 633145003678 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 633145003679 glutamine binding [chemical binding]; other site 633145003680 catalytic triad [active] 633145003681 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 633145003682 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 633145003683 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 633145003684 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 633145003685 active site 633145003686 ribulose/triose binding site [chemical binding]; other site 633145003687 phosphate binding site [ion binding]; other site 633145003688 substrate (anthranilate) binding pocket [chemical binding]; other site 633145003689 product (indole) binding pocket [chemical binding]; other site 633145003690 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 633145003691 active site 633145003692 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 633145003693 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 633145003694 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 633145003695 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 633145003696 pyridoxal 5'-phosphate binding site [chemical binding]; other site 633145003697 catalytic residue [active] 633145003698 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 633145003699 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 633145003700 substrate binding site [chemical binding]; other site 633145003701 active site 633145003702 catalytic residues [active] 633145003703 heterodimer interface [polypeptide binding]; other site 633145003704 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 633145003705 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 633145003706 reductive dehalogenase; Region: RDH; TIGR02486 633145003707 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 633145003708 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 633145003709 reductive dehalogenase; Region: RDH; TIGR02486 633145003710 Transcriptional regulators [Transcription]; Region: MarR; COG1846 633145003711 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 633145003712 Thymidylate synthase complementing protein; Region: Thy1; pfam02511 633145003713 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 633145003714 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 633145003715 Walker A/P-loop; other site 633145003716 ATP binding site [chemical binding]; other site 633145003717 Q-loop/lid; other site 633145003718 ABC transporter signature motif; other site 633145003719 Walker B; other site 633145003720 D-loop; other site 633145003721 H-loop/switch region; other site 633145003722 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 633145003723 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 633145003724 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 633145003725 Walker A/P-loop; other site 633145003726 ATP binding site [chemical binding]; other site 633145003727 Q-loop/lid; other site 633145003728 ABC transporter signature motif; other site 633145003729 Walker B; other site 633145003730 D-loop; other site 633145003731 H-loop/switch region; other site 633145003732 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 633145003733 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 633145003734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633145003735 dimer interface [polypeptide binding]; other site 633145003736 conserved gate region; other site 633145003737 putative PBP binding loops; other site 633145003738 ABC-ATPase subunit interface; other site 633145003739 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 633145003740 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633145003741 dimer interface [polypeptide binding]; other site 633145003742 conserved gate region; other site 633145003743 putative PBP binding loops; other site 633145003744 ABC-ATPase subunit interface; other site 633145003745 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 633145003746 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 633145003747 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 633145003748 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633145003749 S-adenosylmethionine binding site [chemical binding]; other site 633145003750 Transcriptional regulators [Transcription]; Region: MarR; COG1846 633145003751 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 633145003752 dimerization interface [polypeptide binding]; other site 633145003753 putative Zn2+ binding site [ion binding]; other site 633145003754 putative DNA binding site [nucleotide binding]; other site 633145003755 camphor resistance protein CrcB; Provisional; Region: PRK14212 633145003756 Predicted transcriptional regulator [Transcription]; Region: COG1497 633145003757 MarR family; Region: MarR_2; pfam12802 633145003758 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 633145003759 Flavodoxins [Energy production and conversion]; Region: FldA; COG0716 633145003760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633145003761 Major Facilitator Superfamily; Region: MFS_1; pfam07690 633145003762 putative substrate translocation pore; other site 633145003763 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 633145003764 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 633145003765 G1 box; other site 633145003766 GTP/Mg2+ binding site [chemical binding]; other site 633145003767 Switch I region; other site 633145003768 G2 box; other site 633145003769 G3 box; other site 633145003770 Switch II region; other site 633145003771 G4 box; other site 633145003772 G5 box; other site 633145003773 Nucleoside recognition; Region: Gate; pfam07670 633145003774 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 633145003775 Nucleoside recognition; Region: Gate; pfam07670 633145003776 FeoA domain; Region: FeoA; pfam04023 633145003777 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 633145003778 metal binding site 2 [ion binding]; metal-binding site 633145003779 putative DNA binding helix; other site 633145003780 metal binding site 1 [ion binding]; metal-binding site 633145003781 dimer interface [polypeptide binding]; other site 633145003782 structural Zn2+ binding site [ion binding]; other site 633145003783 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 633145003784 SmpB-tmRNA interface; other site 633145003785 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 633145003786 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 633145003787 catalytic residues [active] 633145003788 catalytic nucleophile [active] 633145003789 Recombinase; Region: Recombinase; pfam07508 633145003790 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 633145003791 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 633145003792 Resolvase, N terminal domain; Region: Resolvase; smart00857 633145003793 catalytic residues [active] 633145003794 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 633145003795 ParB-like nuclease domain; Region: ParB; smart00470 633145003796 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 633145003797 active site 633145003798 metal binding site [ion binding]; metal-binding site 633145003799 interdomain interaction site; other site 633145003800 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 633145003801 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 633145003802 Active Sites [active] 633145003803 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 633145003804 DNA methylase; Region: N6_N4_Mtase; cl17433 633145003805 Methyltransferase domain; Region: Methyltransf_26; pfam13659 633145003806 MvaI/BcnI restriction endonuclease family; Region: MvaI_BcnI; pfam15515 633145003807 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 633145003808 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 633145003809 catalytic residues [active] 633145003810 catalytic nucleophile [active] 633145003811 Recombinase; Region: Recombinase; pfam07508 633145003812 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 633145003813 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 633145003814 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 633145003815 catalytic residues [active] 633145003816 NTPase; Region: NTPase_1; cl17478 633145003817 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 633145003818 ParB-like nuclease domain; Region: ParB; smart00470 633145003819 CHC2 zinc finger; Region: zf-CHC2; cl17510 633145003820 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 633145003821 active site 633145003822 metal binding site [ion binding]; metal-binding site 633145003823 interdomain interaction site; other site 633145003824 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 633145003825 Winged helix-turn helix; Region: HTH_29; pfam13551 633145003826 Rubredoxin [Energy production and conversion]; Region: COG1773 633145003827 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 633145003828 iron binding site [ion binding]; other site 633145003829 FMN-binding domain; Region: FMN_bind; pfam04205 633145003830 4Fe-4S binding domain; Region: Fer4_5; pfam12801 633145003831 4Fe-4S binding domain; Region: Fer4_5; pfam12801 633145003832 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 633145003833 reductive dehalogenase; Region: RDH; TIGR02486 633145003834 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 633145003835 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 633145003836 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 633145003837 catalytic residues [active] 633145003838 catalytic nucleophile [active] 633145003839 Recombinase; Region: Recombinase; pfam07508 633145003840 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 633145003841 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 633145003842 Resolvase, N terminal domain; Region: Resolvase; smart00857 633145003843 catalytic residues [active] 633145003844 catalytic nucleophile [active] 633145003845 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 633145003846 ParB-like nuclease domain; Region: ParB; smart00470 633145003847 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 633145003848 active site 633145003849 metal binding site [ion binding]; metal-binding site 633145003850 interdomain interaction site; other site 633145003851 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 633145003852 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 633145003853 CRISPR-associated protein (Cas_Cas2CT1978); Region: Cas_Cas2CT1978; pfam09707 633145003854 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 633145003855 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 633145003856 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 633145003857 CT1975-like protein; Region: Cas_CT1975; pfam09344 633145003858 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 633145003859 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 633145003860 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 633145003861 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 633145003862 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 633145003863 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 633145003864 Double zinc ribbon; Region: DZR; pfam12773 633145003865 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 633145003866 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 633145003867 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 633145003868 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 633145003869 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633145003870 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 633145003871 Walker A motif; other site 633145003872 ATP binding site [chemical binding]; other site 633145003873 Walker B motif; other site 633145003874 arginine finger; other site 633145003875 Predicted transcriptional regulator [Transcription]; Region: COG2378 633145003876 HTH domain; Region: HTH_11; cl17392 633145003877 WYL domain; Region: WYL; pfam13280 633145003878 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 633145003879 putative DNA binding site [nucleotide binding]; other site 633145003880 dimerization interface [polypeptide binding]; other site 633145003881 putative Zn2+ binding site [ion binding]; other site 633145003882 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 633145003883 active site 633145003884 NTP binding site [chemical binding]; other site 633145003885 metal binding triad [ion binding]; metal-binding site 633145003886 antibiotic binding site [chemical binding]; other site 633145003887 Transcriptional regulators [Transcription]; Region: MarR; COG1846 633145003888 MarR family; Region: MarR_2; pfam12802 633145003889 Penicillinase repressor; Region: Penicillinase_R; cl17580 633145003890 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 633145003891 reductive dehalogenase; Region: RDH; TIGR02486 633145003892 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 633145003893 Flagellin N-methylase; Region: FliB; pfam03692 633145003894 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 633145003895 Ligand Binding Site [chemical binding]; other site 633145003896 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 633145003897 reductive dehalogenase; Region: RDH; TIGR02486 633145003898 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 633145003899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633145003900 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 633145003901 intermolecular recognition site; other site 633145003902 active site 633145003903 dimerization interface [polypeptide binding]; other site 633145003904 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 633145003905 DNA binding site [nucleotide binding] 633145003906 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 633145003907 Transcriptional regulators [Transcription]; Region: MarR; COG1846 633145003908 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 633145003909 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 633145003910 Radical SAM superfamily; Region: Radical_SAM; pfam04055 633145003911 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 633145003912 FeS/SAM binding site; other site 633145003913 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 633145003914 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 633145003915 reductive dehalogenase; Region: RDH; TIGR02486 633145003916 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 633145003917 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 633145003918 reductive dehalogenase; Region: RDH; TIGR02486 633145003919 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 633145003920 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 633145003921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633145003922 active site 633145003923 phosphorylation site [posttranslational modification] 633145003924 intermolecular recognition site; other site 633145003925 dimerization interface [polypeptide binding]; other site 633145003926 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 633145003927 DNA binding site [nucleotide binding] 633145003928 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 633145003929 PAS domain; Region: PAS_9; pfam13426 633145003930 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145003931 putative active site [active] 633145003932 heme pocket [chemical binding]; other site 633145003933 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 633145003934 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 633145003935 dimer interface [polypeptide binding]; other site 633145003936 phosphorylation site [posttranslational modification] 633145003937 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633145003938 ATP binding site [chemical binding]; other site 633145003939 Mg2+ binding site [ion binding]; other site 633145003940 G-X-G motif; other site 633145003941 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 633145003942 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 633145003943 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 633145003944 DNA binding residues [nucleotide binding] 633145003945 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 633145003946 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 633145003947 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 633145003948 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 633145003949 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 633145003950 reductive dehalogenase; Region: RDH; TIGR02486 633145003951 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 633145003952 Transcriptional regulators [Transcription]; Region: MarR; COG1846 633145003953 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 633145003954 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 633145003955 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 633145003956 reductive dehalogenase; Region: RDH; TIGR02486 633145003957 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 633145003958 Transcriptional regulators [Transcription]; Region: MarR; COG1846 633145003959 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 633145003960 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 633145003961 reductive dehalogenase; Region: RDH; TIGR02486 633145003962 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 633145003963 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 633145003964 Ligand Binding Site [chemical binding]; other site 633145003965 Flagellin N-methylase; Region: FliB; pfam03692 633145003966 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 633145003967 reductive dehalogenase; Region: RDH; TIGR02486 633145003968 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 633145003969 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 633145003970 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 633145003971 Putative zinc- or iron-chelating domain; Region: CxxCxxCC; cl00497 633145003972 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 633145003973 reductive dehalogenase; Region: RDH; TIGR02486 633145003974 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 633145003975 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 633145003976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633145003977 active site 633145003978 phosphorylation site [posttranslational modification] 633145003979 intermolecular recognition site; other site 633145003980 dimerization interface [polypeptide binding]; other site 633145003981 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 633145003982 DNA binding site [nucleotide binding] 633145003983 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145003984 PAS domain; Region: PAS_9; pfam13426 633145003985 putative active site [active] 633145003986 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145003987 putative active site [active] 633145003988 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 633145003989 heme pocket [chemical binding]; other site 633145003990 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 633145003991 dimer interface [polypeptide binding]; other site 633145003992 phosphorylation site [posttranslational modification] 633145003993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633145003994 ATP binding site [chemical binding]; other site 633145003995 Mg2+ binding site [ion binding]; other site 633145003996 G-X-G motif; other site 633145003997 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 633145003998 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145003999 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 633145004000 putative active site [active] 633145004001 heme pocket [chemical binding]; other site 633145004002 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145004003 putative active site [active] 633145004004 heme pocket [chemical binding]; other site 633145004005 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145004006 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 633145004007 putative active site [active] 633145004008 heme pocket [chemical binding]; other site 633145004009 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145004010 histidine kinase; Provisional; Region: PRK13557 633145004011 putative active site [active] 633145004012 heme pocket [chemical binding]; other site 633145004013 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 633145004014 dimer interface [polypeptide binding]; other site 633145004015 phosphorylation site [posttranslational modification] 633145004016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633145004017 ATP binding site [chemical binding]; other site 633145004018 Mg2+ binding site [ion binding]; other site 633145004019 G-X-G motif; other site 633145004020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633145004021 active site 633145004022 phosphorylation site [posttranslational modification] 633145004023 intermolecular recognition site; other site 633145004024 dimerization interface [polypeptide binding]; other site 633145004025 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 633145004026 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 633145004027 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 633145004028 reductive dehalogenase; Region: RDH; TIGR02486 633145004029 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 633145004030 Transcriptional regulators [Transcription]; Region: MarR; COG1846 633145004031 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 633145004032 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 633145004033 reductive dehalogenase; Region: RDH; TIGR02486 633145004034 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 633145004035 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 633145004036 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 633145004037 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145004038 PAS fold; Region: PAS_4; pfam08448 633145004039 putative active site [active] 633145004040 heme pocket [chemical binding]; other site 633145004041 PAS domain S-box; Region: sensory_box; TIGR00229 633145004042 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145004043 putative active site [active] 633145004044 heme pocket [chemical binding]; other site 633145004045 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 633145004046 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145004047 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 633145004048 putative active site [active] 633145004049 heme pocket [chemical binding]; other site 633145004050 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145004051 putative active site [active] 633145004052 heme pocket [chemical binding]; other site 633145004053 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 633145004054 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145004055 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 633145004056 putative active site [active] 633145004057 heme pocket [chemical binding]; other site 633145004058 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145004059 putative active site [active] 633145004060 heme pocket [chemical binding]; other site 633145004061 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 633145004062 dimer interface [polypeptide binding]; other site 633145004063 phosphorylation site [posttranslational modification] 633145004064 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633145004065 ATP binding site [chemical binding]; other site 633145004066 Mg2+ binding site [ion binding]; other site 633145004067 G-X-G motif; other site 633145004068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633145004069 active site 633145004070 phosphorylation site [posttranslational modification] 633145004071 intermolecular recognition site; other site 633145004072 dimerization interface [polypeptide binding]; other site 633145004073 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 633145004074 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633145004075 active site 633145004076 phosphorylation site [posttranslational modification] 633145004077 intermolecular recognition site; other site 633145004078 dimerization interface [polypeptide binding]; other site 633145004079 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 633145004080 Zn2+ binding site [ion binding]; other site 633145004081 Mg2+ binding site [ion binding]; other site 633145004082 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 633145004083 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 633145004084 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 633145004085 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145004086 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 633145004087 putative active site [active] 633145004088 heme pocket [chemical binding]; other site 633145004089 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145004090 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 633145004091 putative active site [active] 633145004092 heme pocket [chemical binding]; other site 633145004093 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 633145004094 dimer interface [polypeptide binding]; other site 633145004095 phosphorylation site [posttranslational modification] 633145004096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633145004097 ATP binding site [chemical binding]; other site 633145004098 Mg2+ binding site [ion binding]; other site 633145004099 G-X-G motif; other site 633145004100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633145004101 active site 633145004102 phosphorylation site [posttranslational modification] 633145004103 intermolecular recognition site; other site 633145004104 dimerization interface [polypeptide binding]; other site 633145004105 DOMON-like domain of copper-dependent monooxygenases and related proteins; Region: DOMON_DOH; cd09631 633145004106 putative ligand binding site [chemical binding]; other site 633145004107 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 633145004108 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 633145004109 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 633145004110 DNA binding residues [nucleotide binding] 633145004111 dimer interface [polypeptide binding]; other site 633145004112 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633145004113 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633145004114 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633145004115 Walker A/P-loop; other site 633145004116 ATP binding site [chemical binding]; other site 633145004117 Q-loop/lid; other site 633145004118 ABC transporter signature motif; other site 633145004119 Walker B; other site 633145004120 D-loop; other site 633145004121 H-loop/switch region; other site 633145004122 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 633145004123 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 633145004124 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 633145004125 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 633145004126 Protein export membrane protein; Region: SecD_SecF; cl14618 633145004127 Transcriptional regulators [Transcription]; Region: MarR; COG1846 633145004128 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 633145004129 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 633145004130 reductive dehalogenase; Region: RDH; TIGR02486 633145004131 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 633145004132 Transcriptional regulators [Transcription]; Region: MarR; COG1846 633145004133 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 633145004134 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 633145004135 B12 binding site [chemical binding]; other site 633145004136 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 633145004137 Radical SAM superfamily; Region: Radical_SAM; pfam04055 633145004138 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 633145004139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633145004140 Major Facilitator Superfamily; Region: MFS_1; pfam07690 633145004141 putative substrate translocation pore; other site 633145004142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633145004143 Transcriptional regulators [Transcription]; Region: MarR; COG1846 633145004144 putative DNA binding site [nucleotide binding]; other site 633145004145 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 633145004146 putative Zn2+ binding site [ion binding]; other site 633145004147 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 633145004148 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 633145004149 reductive dehalogenase; Region: RDH; TIGR02486 633145004150 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 633145004151 Transcriptional regulators [Transcription]; Region: MarR; COG1846 633145004152 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 633145004153 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 633145004154 reductive dehalogenase; Region: RDH; TIGR02486 633145004155 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 633145004156 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 633145004157 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 633145004158 putative active site [active] 633145004159 heme pocket [chemical binding]; other site 633145004160 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 633145004161 dimer interface [polypeptide binding]; other site 633145004162 phosphorylation site [posttranslational modification] 633145004163 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633145004164 ATP binding site [chemical binding]; other site 633145004165 Mg2+ binding site [ion binding]; other site 633145004166 G-X-G motif; other site 633145004167 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 633145004168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633145004169 active site 633145004170 phosphorylation site [posttranslational modification] 633145004171 intermolecular recognition site; other site 633145004172 dimerization interface [polypeptide binding]; other site 633145004173 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 633145004174 DNA binding site [nucleotide binding] 633145004175 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 633145004176 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 633145004177 reductive dehalogenase; Region: RDH; TIGR02486 633145004178 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 633145004179 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 633145004180 Prephenate dehydratase; Region: PDT; pfam00800 633145004181 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 633145004182 putative L-Phe binding site [chemical binding]; other site 633145004183 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 633145004184 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 633145004185 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 633145004186 GatB domain; Region: GatB_Yqey; smart00845 633145004187 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 633145004188 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 633145004189 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 633145004190 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 633145004191 DNA binding residues [nucleotide binding] 633145004192 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 633145004193 Pectic acid lyase; Region: Pec_lyase; cl19904 633145004194 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 633145004195 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl19197 633145004196 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 633145004197 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl19174 633145004198 hydrogenase membrane subunit; Validated; Region: PRK08676 633145004199 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 633145004200 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 633145004201 NADH dehydrogenase; Region: NADHdh; cl00469 633145004202 hydrogenase membrane subunit; Validated; Region: PRK08667 633145004203 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 633145004204 methylglyoxal synthase; Validated; Region: mgsA; PRK05234 633145004205 substrate binding site [chemical binding]; other site 633145004206 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 633145004207 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 633145004208 Mechanosensitive ion channel; Region: MS_channel; pfam00924 633145004209 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 633145004210 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 633145004211 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 633145004212 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 633145004213 putative NADP binding site [chemical binding]; other site 633145004214 putative substrate binding site [chemical binding]; other site 633145004215 active site 633145004216 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 633145004217 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633145004218 NAD(P) binding site [chemical binding]; other site 633145004219 active site 633145004220 peroxiredoxin; Provisional; Region: PRK13189 633145004221 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 633145004222 dimer interface [polypeptide binding]; other site 633145004223 decamer (pentamer of dimers) interface [polypeptide binding]; other site 633145004224 catalytic triad [active] 633145004225 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 633145004226 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 633145004227 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 633145004228 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 633145004229 Peptidase family M48; Region: Peptidase_M48; cl12018 633145004230 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 633145004231 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 633145004232 trimer interface [polypeptide binding]; other site 633145004233 active site 633145004234 substrate binding site [chemical binding]; other site 633145004235 CoA binding site [chemical binding]; other site 633145004236 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 633145004237 Quinolinate synthetase A protein; Region: NadA; pfam02445 633145004238 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 633145004239 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633145004240 S-adenosylmethionine binding site [chemical binding]; other site 633145004241 AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061 633145004242 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309 633145004243 dimerization interface [polypeptide binding]; other site 633145004244 putative ATP binding site [chemical binding]; other site 633145004245 Predicted transcriptional regulator [Transcription]; Region: COG1959 633145004246 Rrf2 family protein; Region: rrf2_super; TIGR00738 633145004247 ApbE family; Region: ApbE; pfam02424 633145004248 FMN-binding domain; Region: FMN_bind; pfam04205 633145004249 4Fe-4S binding domain; Region: Fer4_5; pfam12801 633145004250 FMN-binding domain; Region: FMN_bind; pfam04205 633145004251 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 633145004252 4Fe-4S binding domain; Region: Fer4_5; pfam12801 633145004253 4Fe-4S binding domain; Region: Fer4_5; pfam12801 633145004254 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 633145004255 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 633145004256 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 633145004257 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 633145004258 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 633145004259 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 633145004260 substrate binding pocket [chemical binding]; other site 633145004261 dimer interface [polypeptide binding]; other site 633145004262 inhibitor binding site; inhibition site 633145004263 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 633145004264 catalytic center binding site [active] 633145004265 ATP binding site [chemical binding]; other site 633145004266 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 633145004267 active site 633145004268 recombinase A; Provisional; Region: recA; PRK09354 633145004269 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 633145004270 hexamer interface [polypeptide binding]; other site 633145004271 Walker A motif; other site 633145004272 ATP binding site [chemical binding]; other site 633145004273 Walker B motif; other site 633145004274 recombination regulator RecX; Reviewed; Region: recX; PRK00117 633145004275 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 633145004276 ribonuclease Y; Region: RNase_Y; TIGR03319 633145004277 KH domain; Region: KH_1; pfam00013 633145004278 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 633145004279 Zn2+ binding site [ion binding]; other site 633145004280 Mg2+ binding site [ion binding]; other site 633145004281 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 633145004282 putative active site [active] 633145004283 metal binding site [ion binding]; metal-binding site 633145004284 homodimer binding site [polypeptide binding]; other site 633145004285 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 633145004286 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 633145004287 active site 633145004288 membrane protein; Provisional; Region: PRK14417 633145004289 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 633145004290 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 633145004291 minor groove reading motif; other site 633145004292 helix-hairpin-helix signature motif; other site 633145004293 substrate binding pocket [chemical binding]; other site 633145004294 active site 633145004295 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 633145004296 homodimer interaction site [polypeptide binding]; other site 633145004297 cofactor binding site; other site 633145004298 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 633145004299 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 633145004300 active site 633145004301 catalytic residues [active] 633145004302 metal binding site [ion binding]; metal-binding site 633145004303 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 633145004304 nucleotide binding site/active site [active] 633145004305 HIT family signature motif; other site 633145004306 catalytic residue [active] 633145004307 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 633145004308 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 633145004309 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 633145004310 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 633145004311 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 633145004312 Walker A/P-loop; other site 633145004313 ATP binding site [chemical binding]; other site 633145004314 Q-loop/lid; other site 633145004315 ABC transporter signature motif; other site 633145004316 Walker B; other site 633145004317 D-loop; other site 633145004318 H-loop/switch region; other site 633145004319 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 633145004320 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 633145004321 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 633145004322 Bacterial PH domain; Region: bPH_2; cl01348 633145004323 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 633145004324 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 633145004325 trimer interface [polypeptide binding]; other site 633145004326 putative Zn binding site [ion binding]; other site 633145004327 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 633145004328 non-heme iron binding site [ion binding]; other site 633145004329 dimer interface [polypeptide binding]; other site 633145004330 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 633145004331 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 633145004332 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935 633145004333 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 633145004334 putative cation:proton antiport protein; Provisional; Region: PRK10669 633145004335 TrkA-N domain; Region: TrkA_N; pfam02254 633145004336 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 633145004337 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 633145004338 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 633145004339 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 633145004340 FeS/SAM binding site; other site 633145004341 DNA gyrase subunit A; Validated; Region: PRK05560 633145004342 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 633145004343 CAP-like domain; other site 633145004344 active site 633145004345 primary dimer interface [polypeptide binding]; other site 633145004346 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 633145004347 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 633145004348 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 633145004349 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 633145004350 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 633145004351 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 633145004352 binding surface 633145004353 Tetratricopeptide repeat; Region: TPR_16; pfam13432 633145004354 TPR motif; other site 633145004355 NifU-like domain; Region: NifU; cl00484 633145004356 aspartate kinase; Reviewed; Region: PRK06635 633145004357 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 633145004358 putative nucleotide binding site [chemical binding]; other site 633145004359 putative catalytic residues [active] 633145004360 putative Mg ion binding site [ion binding]; other site 633145004361 putative aspartate binding site [chemical binding]; other site 633145004362 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 633145004363 putative allosteric regulatory site; other site 633145004364 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 633145004365 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 633145004366 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 633145004367 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 633145004368 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 633145004369 homodimer interface [polypeptide binding]; other site 633145004370 metal binding site [ion binding]; metal-binding site 633145004371 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 633145004372 homodimer interface [polypeptide binding]; other site 633145004373 active site 633145004374 putative chemical substrate binding site [chemical binding]; other site 633145004375 metal binding site [ion binding]; metal-binding site 633145004376 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 633145004377 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 633145004378 LexA repressor; Validated; Region: PRK00215 633145004379 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 633145004380 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 633145004381 Catalytic site [active] 633145004382 L-fuculose phosphate aldolase; Provisional; Region: PRK08660 633145004383 intersubunit interface [polypeptide binding]; other site 633145004384 active site 633145004385 Zn2+ binding site [ion binding]; other site 633145004386 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 633145004387 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 633145004388 putative active site [active] 633145004389 substrate binding site [chemical binding]; other site 633145004390 putative cosubstrate binding site; other site 633145004391 catalytic site [active] 633145004392 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 633145004393 substrate binding site [chemical binding]; other site