-- dump date 20140619_060023 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1193807000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1193807000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1193807000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1193807000004 Walker A motif; other site 1193807000005 ATP binding site [chemical binding]; other site 1193807000006 Walker B motif; other site 1193807000007 arginine finger; other site 1193807000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1193807000009 DnaA box-binding interface [nucleotide binding]; other site 1193807000010 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1193807000011 GTP1/OBG; Region: GTP1_OBG; pfam01018 1193807000012 Obg GTPase; Region: Obg; cd01898 1193807000013 G1 box; other site 1193807000014 GTP/Mg2+ binding site [chemical binding]; other site 1193807000015 Switch I region; other site 1193807000016 G2 box; other site 1193807000017 G3 box; other site 1193807000018 Switch II region; other site 1193807000019 G4 box; other site 1193807000020 G5 box; other site 1193807000021 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1193807000022 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1193807000023 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1193807000024 active site 1193807000025 (T/H)XGH motif; other site 1193807000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1193807000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1193807000028 ATP binding site [chemical binding]; other site 1193807000029 Mg2+ binding site [ion binding]; other site 1193807000030 G-X-G motif; other site 1193807000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1193807000032 anchoring element; other site 1193807000033 dimer interface [polypeptide binding]; other site 1193807000034 ATP binding site [chemical binding]; other site 1193807000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1193807000036 active site 1193807000037 putative metal-binding site [ion binding]; other site 1193807000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1193807000039 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1193807000040 HD domain; Region: HD_4; pfam13328 1193807000041 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1193807000042 synthetase active site [active] 1193807000043 NTP binding site [chemical binding]; other site 1193807000044 metal binding site [ion binding]; metal-binding site 1193807000045 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1193807000046 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1193807000047 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1193807000048 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1193807000049 dimer interface [polypeptide binding]; other site 1193807000050 motif 1; other site 1193807000051 active site 1193807000052 motif 2; other site 1193807000053 motif 3; other site 1193807000054 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1193807000055 anticodon binding site; other site 1193807000056 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1193807000057 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1193807000058 NAD(P) binding pocket [chemical binding]; other site 1193807000059 membrane protein; Provisional; Region: PRK14416 1193807000060 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1193807000061 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1193807000062 homodimer interface [polypeptide binding]; other site 1193807000063 substrate-cofactor binding pocket; other site 1193807000064 catalytic residue [active] 1193807000065 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1193807000066 active site 1193807000067 DNA polymerase IV; Validated; Region: PRK02406 1193807000068 DNA binding site [nucleotide binding] 1193807000069 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1193807000070 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1193807000071 active site 1193807000072 dimer interface [polypeptide binding]; other site 1193807000073 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 1193807000074 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 1193807000075 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 1193807000076 SNF2 Helicase protein; Region: DUF3670; pfam12419 1193807000077 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1193807000078 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1193807000079 dimerization interface [polypeptide binding]; other site 1193807000080 putative tRNAtyr binding site [nucleotide binding]; other site 1193807000081 putative active site [active] 1193807000082 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1193807000083 metal binding site 2 [ion binding]; metal-binding site 1193807000084 putative DNA binding helix; other site 1193807000085 metal binding site 1 [ion binding]; metal-binding site 1193807000086 dimer interface [polypeptide binding]; other site 1193807000087 structural Zn2+ binding site [ion binding]; other site 1193807000088 Pleckstrin homology-like domain; Region: PH-like; cl17171 1193807000089 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1193807000090 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1193807000091 Competence protein; Region: Competence; pfam03772 1193807000092 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1193807000093 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1193807000094 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1193807000095 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1193807000096 TrkA-N domain; Region: TrkA_N; pfam02254 1193807000097 TrkA-C domain; Region: TrkA_C; pfam02080 1193807000098 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1193807000099 TrkA-N domain; Region: TrkA_N; pfam02254 1193807000100 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1193807000101 Ligand Binding Site [chemical binding]; other site 1193807000102 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1193807000103 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1193807000104 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1193807000105 TrkA-N domain; Region: TrkA_N; pfam02254 1193807000106 TrkA-C domain; Region: TrkA_C; pfam02080 1193807000107 TrkA-N domain; Region: TrkA_N; pfam02254 1193807000108 TrkA-C domain; Region: TrkA_C; pfam02080 1193807000109 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1193807000110 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1193807000111 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1193807000112 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1193807000113 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1193807000114 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1193807000115 catalytic site [active] 1193807000116 G-X2-G-X-G-K; other site 1193807000117 hypothetical protein; Provisional; Region: PRK04323 1193807000118 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 1193807000119 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 1193807000120 FAD binding pocket [chemical binding]; other site 1193807000121 FAD binding motif [chemical binding]; other site 1193807000122 phosphate binding motif [ion binding]; other site 1193807000123 beta-alpha-beta structure motif; other site 1193807000124 NAD binding pocket [chemical binding]; other site 1193807000125 Iron coordination center [ion binding]; other site 1193807000126 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 1193807000127 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1193807000128 SnoaL-like domain; Region: SnoaL_3; pfam13474 1193807000129 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1193807000130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1193807000131 S-adenosylmethionine binding site [chemical binding]; other site 1193807000132 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 1193807000133 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1193807000134 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 1193807000135 GTP-binding protein YchF; Reviewed; Region: PRK09601 1193807000136 YchF GTPase; Region: YchF; cd01900 1193807000137 G1 box; other site 1193807000138 GTP/Mg2+ binding site [chemical binding]; other site 1193807000139 Switch I region; other site 1193807000140 G2 box; other site 1193807000141 Switch II region; other site 1193807000142 G3 box; other site 1193807000143 G4 box; other site 1193807000144 G5 box; other site 1193807000145 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1193807000146 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1193807000147 DNA polymerase III, delta subunit; Region: holA; TIGR01128 1193807000148 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1193807000149 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1193807000150 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1193807000151 nucleotide binding site [chemical binding]; other site 1193807000152 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1193807000153 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1193807000154 motif 1; other site 1193807000155 active site 1193807000156 motif 2; other site 1193807000157 motif 3; other site 1193807000158 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1193807000159 FlxA-like protein; Region: FlxA; pfam14282 1193807000160 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1193807000161 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1193807000162 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1193807000163 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1193807000164 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1193807000165 active site 1193807000166 NAD binding site [chemical binding]; other site 1193807000167 metal binding site [ion binding]; metal-binding site 1193807000168 Clp protease ATP binding subunit; Region: clpC; CHL00095 1193807000169 Clp amino terminal domain; Region: Clp_N; pfam02861 1193807000170 Clp amino terminal domain; Region: Clp_N; pfam02861 1193807000171 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1193807000172 Walker A motif; other site 1193807000173 ATP binding site [chemical binding]; other site 1193807000174 Walker B motif; other site 1193807000175 arginine finger; other site 1193807000176 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1193807000177 Walker A motif; other site 1193807000178 ATP binding site [chemical binding]; other site 1193807000179 Walker B motif; other site 1193807000180 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1193807000181 DNA repair protein RadA; Provisional; Region: PRK11823 1193807000182 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1193807000183 Walker A motif/ATP binding site; other site 1193807000184 ATP binding site [chemical binding]; other site 1193807000185 Walker B motif; other site 1193807000186 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1193807000187 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1193807000188 substrate binding site; other site 1193807000189 dimer interface; other site 1193807000190 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1193807000191 homotrimer interaction site [polypeptide binding]; other site 1193807000192 zinc binding site [ion binding]; other site 1193807000193 CDP-binding sites; other site 1193807000194 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1193807000195 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1193807000196 active site 1193807000197 HIGH motif; other site 1193807000198 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1193807000199 KMSKS motif; other site 1193807000200 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1193807000201 tRNA binding surface [nucleotide binding]; other site 1193807000202 anticodon binding site; other site 1193807000203 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1193807000204 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1193807000205 catalytic residues [active] 1193807000206 catalytic nucleophile [active] 1193807000207 Recombinase; Region: Recombinase; pfam07508 1193807000208 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1193807000209 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1193807000210 non-specific DNA binding site [nucleotide binding]; other site 1193807000211 salt bridge; other site 1193807000212 sequence-specific DNA binding site [nucleotide binding]; other site 1193807000213 Helix-turn-helix domain; Region: HTH_17; pfam12728 1193807000214 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311 1193807000215 putative active site [active] 1193807000216 catalytic site [active] 1193807000217 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1193807000218 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1193807000219 ATP binding site [chemical binding]; other site 1193807000220 putative Mg++ binding site [ion binding]; other site 1193807000221 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1193807000222 nucleotide binding region [chemical binding]; other site 1193807000223 ATP-binding site [chemical binding]; other site 1193807000224 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 1193807000225 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1193807000226 DNA methylase; Region: N6_N4_Mtase; pfam01555 1193807000227 DNA methylase; Region: N6_N4_Mtase; pfam01555 1193807000228 Restriction endonuclease [Defense mechanisms]; Region: COG3587 1193807000229 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1193807000230 ATP binding site [chemical binding]; other site 1193807000231 putative Mg++ binding site [ion binding]; other site 1193807000232 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 1193807000233 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1193807000234 Walker B; other site 1193807000235 D-loop; other site 1193807000236 H-loop/switch region; other site 1193807000237 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1193807000238 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1193807000239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1193807000240 active site 1193807000241 phosphorylation site [posttranslational modification] 1193807000242 intermolecular recognition site; other site 1193807000243 dimerization interface [polypeptide binding]; other site 1193807000244 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1193807000245 DNA binding site [nucleotide binding] 1193807000246 PAS domain; Region: PAS_9; pfam13426 1193807000247 PAS domain S-box; Region: sensory_box; TIGR00229 1193807000248 PAS domain; Region: PAS; smart00091 1193807000249 putative active site [active] 1193807000250 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1193807000251 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1193807000252 phosphorylation site [posttranslational modification] 1193807000253 dimer interface [polypeptide binding]; other site 1193807000254 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1193807000255 ATP binding site [chemical binding]; other site 1193807000256 Mg2+ binding site [ion binding]; other site 1193807000257 G-X-G motif; other site 1193807000258 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 1193807000259 reductive dehalogenase; Region: RDH; TIGR02486 1193807000260 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 1193807000261 PAS domain S-box; Region: sensory_box; TIGR00229 1193807000262 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1193807000263 putative active site [active] 1193807000264 heme pocket [chemical binding]; other site 1193807000265 PAS domain S-box; Region: sensory_box; TIGR00229 1193807000266 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1193807000267 putative active site [active] 1193807000268 heme pocket [chemical binding]; other site 1193807000269 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1193807000270 dimer interface [polypeptide binding]; other site 1193807000271 phosphorylation site [posttranslational modification] 1193807000272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1193807000273 ATP binding site [chemical binding]; other site 1193807000274 Mg2+ binding site [ion binding]; other site 1193807000275 G-X-G motif; other site 1193807000276 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1193807000277 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1193807000278 active site 1193807000279 phosphorylation site [posttranslational modification] 1193807000280 intermolecular recognition site; other site 1193807000281 dimerization interface [polypeptide binding]; other site 1193807000282 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1193807000283 DNA binding site [nucleotide binding] 1193807000284 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 1193807000285 reductive dehalogenase; Region: RDH; TIGR02486 1193807000286 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 1193807000287 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 1193807000288 reductive dehalogenase; Region: RDH; TIGR02486 1193807000289 Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102 1193807000290 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1193807000291 Ligand Binding Site [chemical binding]; other site 1193807000292 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 1193807000293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1193807000294 active site 1193807000295 phosphorylation site [posttranslational modification] 1193807000296 intermolecular recognition site; other site 1193807000297 dimerization interface [polypeptide binding]; other site 1193807000298 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1193807000299 DNA binding site [nucleotide binding] 1193807000300 PAS domain S-box; Region: sensory_box; TIGR00229 1193807000301 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1193807000302 putative active site [active] 1193807000303 heme pocket [chemical binding]; other site 1193807000304 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1193807000305 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1193807000306 dimer interface [polypeptide binding]; other site 1193807000307 phosphorylation site [posttranslational modification] 1193807000308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1193807000309 ATP binding site [chemical binding]; other site 1193807000310 Mg2+ binding site [ion binding]; other site 1193807000311 G-X-G motif; other site 1193807000312 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1193807000313 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1193807000314 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 1193807000315 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1193807000316 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 1193807000317 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 1193807000318 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1193807000319 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 1193807000320 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1193807000321 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1193807000322 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1193807000323 integron integrase; Region: integrase_gron; TIGR02249 1193807000324 active site 1193807000325 DNA binding site [nucleotide binding] 1193807000326 Int/Topo IB signature motif; other site 1193807000327 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1193807000328 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1193807000329 active site 1193807000330 metal binding site [ion binding]; metal-binding site 1193807000331 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1193807000332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1193807000333 active site 1193807000334 phosphorylation site [posttranslational modification] 1193807000335 intermolecular recognition site; other site 1193807000336 dimerization interface [polypeptide binding]; other site 1193807000337 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1193807000338 DNA binding residues [nucleotide binding] 1193807000339 dimerization interface [polypeptide binding]; other site 1193807000340 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 1193807000341 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1193807000342 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1193807000343 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 1193807000344 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 1193807000345 reductive dehalogenase; Region: RDH; TIGR02486 1193807000346 PAS domain; Region: PAS_9; pfam13426 1193807000347 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1193807000348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1193807000349 ATP binding site [chemical binding]; other site 1193807000350 Mg2+ binding site [ion binding]; other site 1193807000351 G-X-G motif; other site 1193807000352 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1193807000353 integron integrase; Region: integrase_gron; TIGR02249 1193807000354 active site 1193807000355 DNA binding site [nucleotide binding] 1193807000356 Int/Topo IB signature motif; other site 1193807000357 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 1193807000358 reductive dehalogenase; Region: RDH; TIGR02486 1193807000359 PAS domain; Region: PAS_9; pfam13426 1193807000360 PAS domain S-box; Region: sensory_box; TIGR00229 1193807000361 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1193807000362 putative active site [active] 1193807000363 heme pocket [chemical binding]; other site 1193807000364 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1193807000365 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1193807000366 dimer interface [polypeptide binding]; other site 1193807000367 phosphorylation site [posttranslational modification] 1193807000368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1193807000369 ATP binding site [chemical binding]; other site 1193807000370 Mg2+ binding site [ion binding]; other site 1193807000371 G-X-G motif; other site 1193807000372 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1193807000373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1193807000374 active site 1193807000375 phosphorylation site [posttranslational modification] 1193807000376 intermolecular recognition site; other site 1193807000377 dimerization interface [polypeptide binding]; other site 1193807000378 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1193807000379 DNA binding site [nucleotide binding] 1193807000380 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1193807000381 dinuclear metal binding motif [ion binding]; other site 1193807000382 NTPase; Region: NTPase_1; cl17478 1193807000383 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1193807000384 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1193807000385 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1193807000386 GTP binding site; other site 1193807000387 tetrathionate reductase subunit A; Provisional; Region: PRK14991 1193807000388 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1193807000389 molybdopterin cofactor binding site; other site 1193807000390 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1193807000391 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 1193807000392 putative molybdopterin cofactor binding site; other site 1193807000393 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 1193807000394 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 1193807000395 4Fe-4S binding domain; Region: Fer4; cl02805 1193807000396 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1193807000397 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1193807000398 Walker A motif; other site 1193807000399 EDD domain protein, DegV family; Region: DegV; TIGR00762 1193807000400 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1193807000401 E3 Ubiquitin ligase; Region: GIDE; pfam12483 1193807000402 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1193807000403 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1193807000404 putative catalytic site [active] 1193807000405 putative metal binding site [ion binding]; other site 1193807000406 putative phosphate binding site [ion binding]; other site 1193807000407 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1193807000408 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1193807000409 putative substrate-binding site; other site 1193807000410 nickel binding site [ion binding]; other site 1193807000411 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1193807000412 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 1193807000413 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1193807000414 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 1193807000415 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1193807000416 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1193807000417 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1193807000418 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1193807000419 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1193807000420 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1193807000421 Walker A/P-loop; other site 1193807000422 ATP binding site [chemical binding]; other site 1193807000423 Q-loop/lid; other site 1193807000424 ABC transporter signature motif; other site 1193807000425 Walker B; other site 1193807000426 D-loop; other site 1193807000427 H-loop/switch region; other site 1193807000428 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1193807000429 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1193807000430 DJ-1 family protein; Region: not_thiJ; TIGR01383 1193807000431 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1193807000432 conserved cys residue [active] 1193807000433 pyruvate carboxylase subunit B; Validated; Region: PRK09282 1193807000434 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1193807000435 active site 1193807000436 catalytic residues [active] 1193807000437 metal binding site [ion binding]; metal-binding site 1193807000438 homodimer binding site [polypeptide binding]; other site 1193807000439 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1193807000440 carboxyltransferase (CT) interaction site; other site 1193807000441 biotinylation site [posttranslational modification]; other site 1193807000442 pyruvate carboxylase subunit A; Validated; Region: PRK08654 1193807000443 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1193807000444 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1193807000445 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1193807000446 2TM domain; Region: 2TM; pfam13239 1193807000447 4Fe-4S binding domain; Region: Fer4; pfam00037 1193807000448 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1193807000449 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 1193807000450 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1193807000451 4Fe-4S binding domain; Region: Fer4; pfam00037 1193807000452 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1193807000453 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 1193807000454 putative NAD(P) binding site [chemical binding]; other site 1193807000455 catalytic Zn binding site [ion binding]; other site 1193807000456 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1193807000457 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1193807000458 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1193807000459 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1193807000460 GAF domain; Region: GAF; pfam01590 1193807000461 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1193807000462 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1193807000463 putative active site [active] 1193807000464 heme pocket [chemical binding]; other site 1193807000465 PAS domain; Region: PAS; smart00091 1193807000466 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1193807000467 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1193807000468 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1193807000469 putative active site [active] 1193807000470 heme pocket [chemical binding]; other site 1193807000471 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1193807000472 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1193807000473 putative active site [active] 1193807000474 heme pocket [chemical binding]; other site 1193807000475 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1193807000476 dimer interface [polypeptide binding]; other site 1193807000477 phosphorylation site [posttranslational modification] 1193807000478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1193807000479 ATP binding site [chemical binding]; other site 1193807000480 G-X-G motif; other site 1193807000481 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1193807000482 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1193807000483 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1193807000484 catalytic triad [active] 1193807000485 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 1193807000486 Response regulator receiver domain; Region: Response_reg; pfam00072 1193807000487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1193807000488 active site 1193807000489 phosphorylation site [posttranslational modification] 1193807000490 intermolecular recognition site; other site 1193807000491 dimerization interface [polypeptide binding]; other site 1193807000492 Response regulator receiver domain; Region: Response_reg; pfam00072 1193807000493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1193807000494 active site 1193807000495 phosphorylation site [posttranslational modification] 1193807000496 intermolecular recognition site; other site 1193807000497 dimerization interface [polypeptide binding]; other site 1193807000498 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1193807000499 alanine dehydrogenase; Validated; Region: PRK06046 1193807000500 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1193807000501 DNA polymerase, archaeal type II, large subunit; Region: polC; TIGR00354 1193807000502 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1193807000503 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1193807000504 active site 1193807000505 phosphorylation site [posttranslational modification] 1193807000506 intermolecular recognition site; other site 1193807000507 dimerization interface [polypeptide binding]; other site 1193807000508 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1193807000509 DNA binding site [nucleotide binding] 1193807000510 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1193807000511 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1193807000512 dimerization interface [polypeptide binding]; other site 1193807000513 PAS domain; Region: PAS; smart00091 1193807000514 putative active site [active] 1193807000515 heme pocket [chemical binding]; other site 1193807000516 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1193807000517 dimer interface [polypeptide binding]; other site 1193807000518 phosphorylation site [posttranslational modification] 1193807000519 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1193807000520 ATP binding site [chemical binding]; other site 1193807000521 Mg2+ binding site [ion binding]; other site 1193807000522 G-X-G motif; other site 1193807000523 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1193807000524 active site 1193807000525 dimer interfaces [polypeptide binding]; other site 1193807000526 catalytic residues [active] 1193807000527 PBP superfamily domain; Region: PBP_like_2; cl17296 1193807000528 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1193807000529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1193807000530 dimer interface [polypeptide binding]; other site 1193807000531 conserved gate region; other site 1193807000532 putative PBP binding loops; other site 1193807000533 ABC-ATPase subunit interface; other site 1193807000534 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1193807000535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1193807000536 dimer interface [polypeptide binding]; other site 1193807000537 conserved gate region; other site 1193807000538 putative PBP binding loops; other site 1193807000539 ABC-ATPase subunit interface; other site 1193807000540 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14249 1193807000541 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1193807000542 Walker A/P-loop; other site 1193807000543 ATP binding site [chemical binding]; other site 1193807000544 Q-loop/lid; other site 1193807000545 ABC transporter signature motif; other site 1193807000546 Walker B; other site 1193807000547 D-loop; other site 1193807000548 H-loop/switch region; other site 1193807000549 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1193807000550 PhoU domain; Region: PhoU; pfam01895 1193807000551 PhoU domain; Region: PhoU; pfam01895 1193807000552 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1193807000553 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1193807000554 active site 1193807000555 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 1193807000556 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1193807000557 putative dimer interface [polypeptide binding]; other site 1193807000558 [2Fe-2S] cluster binding site [ion binding]; other site 1193807000559 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1193807000560 SLBB domain; Region: SLBB; pfam10531 1193807000561 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1193807000562 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1193807000563 catalytic loop [active] 1193807000564 iron binding site [ion binding]; other site 1193807000565 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1193807000566 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 1193807000567 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1193807000568 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 1193807000569 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; smart00902 1193807000570 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1193807000571 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1193807000572 Protein of unknown function DUF45; Region: DUF45; pfam01863 1193807000573 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1193807000574 EamA-like transporter family; Region: EamA; pfam00892 1193807000575 EamA-like transporter family; Region: EamA; pfam00892 1193807000576 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1193807000577 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 1193807000578 tetramer interface [polypeptide binding]; other site 1193807000579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1193807000580 catalytic residue [active] 1193807000581 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1193807000582 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1193807000583 IncA protein; Region: IncA; pfam04156 1193807000584 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1193807000585 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1193807000586 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1193807000587 active site 1193807000588 phosphorylation site [posttranslational modification] 1193807000589 intermolecular recognition site; other site 1193807000590 dimerization interface [polypeptide binding]; other site 1193807000591 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1193807000592 DNA binding site [nucleotide binding] 1193807000593 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1193807000594 dimer interface [polypeptide binding]; other site 1193807000595 phosphorylation site [posttranslational modification] 1193807000596 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1193807000597 ATP binding site [chemical binding]; other site 1193807000598 Mg2+ binding site [ion binding]; other site 1193807000599 G-X-G motif; other site 1193807000600 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 1193807000601 reductive dehalogenase; Region: RDH; TIGR02486 1193807000602 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 1193807000603 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1193807000604 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1193807000605 ATP binding site [chemical binding]; other site 1193807000606 Mg++ binding site [ion binding]; other site 1193807000607 motif III; other site 1193807000608 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1193807000609 nucleotide binding region [chemical binding]; other site 1193807000610 ATP-binding site [chemical binding]; other site 1193807000611 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1193807000612 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 1193807000613 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1193807000614 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 1193807000615 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1193807000616 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 1193807000617 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1193807000618 molybdopterin cofactor binding site; other site 1193807000619 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1193807000620 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1193807000621 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1193807000622 molybdopterin cofactor binding site; other site 1193807000623 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1193807000624 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1193807000625 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1193807000626 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1193807000627 active site 1193807000628 (T/H)XGH motif; other site 1193807000629 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1193807000630 Colicin V production protein; Region: Colicin_V; pfam02674 1193807000631 pyrroline-5-carboxylate reductase; Region: PLN02688 1193807000632 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1193807000633 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1193807000634 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1193807000635 HIGH motif; other site 1193807000636 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1193807000637 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1193807000638 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1193807000639 active site 1193807000640 KMSKS motif; other site 1193807000641 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1193807000642 tRNA binding surface [nucleotide binding]; other site 1193807000643 HI0933-like protein; Region: HI0933_like; pfam03486 1193807000644 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1193807000645 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1193807000646 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1193807000647 catalytic residues [active] 1193807000648 Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977 1193807000649 Rubredoxin [Energy production and conversion]; Region: COG1773 1193807000650 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 1193807000651 iron binding site [ion binding]; other site 1193807000652 Protein of unknown function (DUF1616); Region: DUF1616; pfam07760 1193807000653 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1193807000654 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1193807000655 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 1193807000656 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1193807000657 active site 1193807000658 motif I; other site 1193807000659 motif II; other site 1193807000660 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1193807000661 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1193807000662 Ligand binding site; other site 1193807000663 Putative Catalytic site; other site 1193807000664 DXD motif; other site 1193807000665 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1193807000666 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1193807000667 active site 1193807000668 UDP-glucose 4 epimerase, subgroup 2, extended (e) SDRs; Region: UDP_G4E_2_SDR_e; cd05234 1193807000669 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1193807000670 NAD binding site [chemical binding]; other site 1193807000671 homodimer interface [polypeptide binding]; other site 1193807000672 active site 1193807000673 putative substrate binding site [chemical binding]; other site 1193807000674 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1193807000675 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 1193807000676 Substrate binding site; other site 1193807000677 Mg++ binding site; other site 1193807000678 metal-binding site 1193807000679 Mg++ binding site; other site 1193807000680 metal-binding site 1193807000681 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 1193807000682 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1193807000683 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1193807000684 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1193807000685 dimer interface [polypeptide binding]; other site 1193807000686 active site 1193807000687 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1193807000688 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1193807000689 active site 1193807000690 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1193807000691 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1193807000692 active site 1193807000693 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1193807000694 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1193807000695 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1193807000696 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1193807000697 S-adenosylmethionine binding site [chemical binding]; other site 1193807000698 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1193807000699 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1193807000700 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 1193807000701 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 1193807000702 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1193807000703 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1193807000704 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1193807000705 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1193807000706 active site 1193807000707 catalytic tetrad [active] 1193807000708 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1193807000709 HEAT repeats; Region: HEAT_2; pfam13646 1193807000710 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 1193807000711 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1193807000712 FeS/SAM binding site; other site 1193807000713 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1193807000714 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 1193807000715 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1193807000716 Coenzyme A binding pocket [chemical binding]; other site 1193807000717 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 1193807000718 reactive center loop; other site 1193807000719 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1193807000720 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1193807000721 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1193807000722 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1193807000723 Walker A/P-loop; other site 1193807000724 ATP binding site [chemical binding]; other site 1193807000725 Q-loop/lid; other site 1193807000726 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1193807000727 ABC transporter signature motif; other site 1193807000728 Walker B; other site 1193807000729 D-loop; other site 1193807000730 ABC transporter; Region: ABC_tran_2; pfam12848 1193807000731 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1193807000732 flavoprotein, HI0933 family; Region: TIGR00275 1193807000733 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1193807000734 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1193807000735 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1193807000736 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1193807000737 TM2 domain; Region: TM2; pfam05154 1193807000738 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1193807000739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1193807000740 active site 1193807000741 phosphorylation site [posttranslational modification] 1193807000742 intermolecular recognition site; other site 1193807000743 dimerization interface [polypeptide binding]; other site 1193807000744 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1193807000745 DNA binding site [nucleotide binding] 1193807000746 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1193807000747 PAS domain; Region: PAS_9; pfam13426 1193807000748 putative active site [active] 1193807000749 heme pocket [chemical binding]; other site 1193807000750 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1193807000751 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1193807000752 dimer interface [polypeptide binding]; other site 1193807000753 phosphorylation site [posttranslational modification] 1193807000754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1193807000755 ATP binding site [chemical binding]; other site 1193807000756 Mg2+ binding site [ion binding]; other site 1193807000757 G-X-G motif; other site 1193807000758 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 1193807000759 reductive dehalogenase; Region: RDH; TIGR02486 1193807000760 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1193807000761 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1193807000762 active site 1193807000763 phosphorylation site [posttranslational modification] 1193807000764 intermolecular recognition site; other site 1193807000765 dimerization interface [polypeptide binding]; other site 1193807000766 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1193807000767 DNA binding site [nucleotide binding] 1193807000768 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1193807000769 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1193807000770 dimer interface [polypeptide binding]; other site 1193807000771 phosphorylation site [posttranslational modification] 1193807000772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1193807000773 ATP binding site [chemical binding]; other site 1193807000774 Mg2+ binding site [ion binding]; other site 1193807000775 G-X-G motif; other site 1193807000776 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 1193807000777 reductive dehalogenase; Region: RDH; TIGR02486 1193807000778 FMN-binding domain; Region: FMN_bind; pfam04205 1193807000779 Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102 1193807000780 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 1193807000781 Ligand Binding Site [chemical binding]; other site 1193807000782 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1193807000783 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1193807000784 FeS/SAM binding site; other site 1193807000785 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1193807000786 active site 1193807000787 putative homodimer interface [polypeptide binding]; other site 1193807000788 SAM binding site [chemical binding]; other site 1193807000789 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 1193807000790 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 1193807000791 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1193807000792 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 1193807000793 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1193807000794 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 1193807000795 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1193807000796 active site 1193807000797 dimer interface [polypeptide binding]; other site 1193807000798 effector binding site; other site 1193807000799 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1193807000800 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 1193807000801 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 1193807000802 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1193807000803 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1193807000804 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1193807000805 catalytic residue [active] 1193807000806 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 1193807000807 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1193807000808 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1193807000809 cobalamin binding residues [chemical binding]; other site 1193807000810 putative BtuC binding residues; other site 1193807000811 dimer interface [polypeptide binding]; other site 1193807000812 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1193807000813 active site 1193807000814 putative homodimer interface [polypeptide binding]; other site 1193807000815 SAM binding site [chemical binding]; other site 1193807000816 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1193807000817 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1193807000818 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1193807000819 ligand binding site [chemical binding]; other site 1193807000820 flexible hinge region; other site 1193807000821 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1193807000822 putative switch regulator; other site 1193807000823 non-specific DNA interactions [nucleotide binding]; other site 1193807000824 DNA binding site [nucleotide binding] 1193807000825 sequence specific DNA binding site [nucleotide binding]; other site 1193807000826 putative cAMP binding site [chemical binding]; other site 1193807000827 HNH endonuclease; Region: HNH_2; pfam13391 1193807000828 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1193807000829 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1193807000830 cofactor binding site; other site 1193807000831 DNA binding site [nucleotide binding] 1193807000832 substrate interaction site [chemical binding]; other site 1193807000833 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1193807000834 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1193807000835 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1193807000836 AIPR protein; Region: AIPR; pfam10592 1193807000837 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 1193807000838 Z1 domain; Region: Z1; pfam10593 1193807000839 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 1193807000840 ATP binding site [chemical binding]; other site 1193807000841 Mg2+ binding site [ion binding]; other site 1193807000842 G-X-G motif; other site 1193807000843 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1193807000844 non-specific DNA binding site [nucleotide binding]; other site 1193807000845 salt bridge; other site 1193807000846 sequence-specific DNA binding site [nucleotide binding]; other site 1193807000847 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1193807000848 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1193807000849 catalytic residues [active] 1193807000850 catalytic nucleophile [active] 1193807000851 Recombinase; Region: Recombinase; pfam07508 1193807000852 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1193807000853 Domain of unknown function (DUF955); Region: DUF955; cl01076 1193807000854 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1193807000855 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1193807000856 non-specific DNA binding site [nucleotide binding]; other site 1193807000857 salt bridge; other site 1193807000858 sequence-specific DNA binding site [nucleotide binding]; other site 1193807000859 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1193807000860 salt bridge; other site 1193807000861 non-specific DNA binding site [nucleotide binding]; other site 1193807000862 sequence-specific DNA binding site [nucleotide binding]; other site 1193807000863 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 1193807000864 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 1193807000865 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1193807000866 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1193807000867 HSP70 interaction site [polypeptide binding]; other site 1193807000868 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1193807000869 Walker B motif; other site 1193807000870 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1193807000871 DNA-binding site [nucleotide binding]; DNA binding site 1193807000872 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1193807000873 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 1193807000874 active site 1193807000875 catalytic triad [active] 1193807000876 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1193807000877 active site 1193807000878 DNA binding site [nucleotide binding] 1193807000879 Int/Topo IB signature motif; other site 1193807000880 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 1193807000881 Domain of unknown function (DUF955); Region: DUF955; cl01076 1193807000882 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1193807000883 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1193807000884 non-specific DNA binding site [nucleotide binding]; other site 1193807000885 salt bridge; other site 1193807000886 sequence-specific DNA binding site [nucleotide binding]; other site 1193807000887 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1193807000888 Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628 1193807000889 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 1193807000890 GIY-YIG motif/motif A; other site 1193807000891 putative active site [active] 1193807000892 putative metal binding site [ion binding]; other site 1193807000893 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 1193807000894 beta-clamp/clamp loader binding surface; other site 1193807000895 beta-clamp/translesion DNA polymerase binding surface; other site 1193807000896 DNA binding domain, excisionase family; Region: excise; TIGR01764 1193807000897 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 1193807000898 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1193807000899 DNA methylase; Region: N6_N4_Mtase; pfam01555 1193807000900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1193807000901 S-adenosylmethionine binding site [chemical binding]; other site 1193807000902 DNA methylase; Region: N6_N4_Mtase; cl17433 1193807000903 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1193807000904 PglZ domain; Region: PglZ; pfam08665 1193807000905 Predicted ATP-dependent Lon-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG4930 1193807000906 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 1193807000907 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1193807000908 transposase/IS protein; Provisional; Region: PRK09183 1193807000909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1193807000910 Walker A motif; other site 1193807000911 ATP binding site [chemical binding]; other site 1193807000912 Walker B motif; other site 1193807000913 arginine finger; other site 1193807000914 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1193807000915 Integrase core domain; Region: rve; pfam00665 1193807000916 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1193807000917 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1193807000918 CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein) [Energy production and conversion]; Region: CdhE; COG1456 1193807000919 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 1193807000920 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 1193807000921 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1193807000922 P loop; other site 1193807000923 Nucleotide binding site [chemical binding]; other site 1193807000924 DTAP/Switch II; other site 1193807000925 Switch I; other site 1193807000926 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1193807000927 P loop; other site 1193807000928 Nucleotide binding site [chemical binding]; other site 1193807000929 DTAP/Switch II; other site 1193807000930 Switch I; other site 1193807000931 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 1193807000932 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1193807000933 arsenical-resistance protein; Region: acr3; TIGR00832 1193807000934 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1193807000935 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1193807000936 active site 1193807000937 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1193807000938 dimerization interface [polypeptide binding]; other site 1193807000939 putative DNA binding site [nucleotide binding]; other site 1193807000940 putative Zn2+ binding site [ion binding]; other site 1193807000941 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1193807000942 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1193807000943 nucleophile elbow; other site 1193807000944 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1193807000945 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1193807000946 HAS barrel domain; Region: HAS-barrel; pfam09378 1193807000947 Domain of unknown function DUF87; Region: DUF87; pfam01935 1193807000948 AAA-like domain; Region: AAA_10; pfam12846 1193807000949 NurA nuclease; Region: NurA; smart00933 1193807000950 LysE type translocator; Region: LysE; pfam01810 1193807000951 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1193807000952 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 1193807000953 active site 1193807000954 Zn binding site [ion binding]; other site 1193807000955 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1193807000956 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1193807000957 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 1193807000958 Protein export membrane protein; Region: SecD_SecF; pfam02355 1193807000959 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1193807000960 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1193807000961 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1193807000962 active site 1193807000963 NTP binding site [chemical binding]; other site 1193807000964 metal binding triad [ion binding]; metal-binding site 1193807000965 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1193807000966 Zn2+ binding site [ion binding]; other site 1193807000967 Mg2+ binding site [ion binding]; other site 1193807000968 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1193807000969 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1193807000970 non-specific DNA binding site [nucleotide binding]; other site 1193807000971 salt bridge; other site 1193807000972 sequence-specific DNA binding site [nucleotide binding]; other site 1193807000973 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1193807000974 primosomal protein N' Region: priA; TIGR00595 1193807000975 ATP binding site [chemical binding]; other site 1193807000976 putative Mg++ binding site [ion binding]; other site 1193807000977 Trm112p-like protein; Region: Trm112p; cl01066 1193807000978 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 1193807000979 ATP-binding site [chemical binding]; other site 1193807000980 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1193807000981 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1193807000982 cell division protein MraZ; Reviewed; Region: PRK00326 1193807000983 MraZ protein; Region: MraZ; pfam02381 1193807000984 MraZ protein; Region: MraZ; pfam02381 1193807000985 MraW methylase family; Region: Methyltransf_5; pfam01795 1193807000986 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1193807000987 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1193807000988 Cell division protein FtsA; Region: FtsA; smart00842 1193807000989 Cell division protein FtsA; Region: FtsA; pfam14450 1193807000990 cell division protein FtsZ; Validated; Region: PRK09330 1193807000991 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1193807000992 nucleotide binding site [chemical binding]; other site 1193807000993 SulA interaction site; other site 1193807000994 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1193807000995 ATP cone domain; Region: ATP-cone; pfam03477 1193807000996 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 1193807000997 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1193807000998 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1193807000999 active site 1193807001000 dimer interface [polypeptide binding]; other site 1193807001001 effector binding site; other site 1193807001002 TSCPD domain; Region: TSCPD; pfam12637 1193807001003 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1193807001004 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1193807001005 LabA_like proteins; Region: LabA_like; cd06167 1193807001006 putative metal binding site [ion binding]; other site 1193807001007 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 1193807001008 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1193807001009 FeS/SAM binding site; other site 1193807001010 Yqey-like protein; Region: YqeY; pfam09424 1193807001011 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1193807001012 Mor transcription activator family; Region: Mor; cl02360 1193807001013 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 1193807001014 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1193807001015 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1193807001016 Terminase-like family; Region: Terminase_6; pfam03237 1193807001017 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1193807001018 Putative zinc ribbon domain; Region: DUF164; pfam02591 1193807001019 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1193807001020 active site 1193807001021 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 1193807001022 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1193807001023 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1193807001024 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1193807001025 protein binding site [polypeptide binding]; other site 1193807001026 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1193807001027 Catalytic dyad [active] 1193807001028 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1193807001029 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1193807001030 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1193807001031 dimer interface [polypeptide binding]; other site 1193807001032 motif 1; other site 1193807001033 active site 1193807001034 motif 2; other site 1193807001035 motif 3; other site 1193807001036 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1193807001037 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1193807001038 putative tRNA-binding site [nucleotide binding]; other site 1193807001039 B3/4 domain; Region: B3_4; pfam03483 1193807001040 tRNA synthetase B5 domain; Region: B5; pfam03484 1193807001041 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1193807001042 dimer interface [polypeptide binding]; other site 1193807001043 motif 1; other site 1193807001044 motif 3; other site 1193807001045 motif 2; other site 1193807001046 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1193807001047 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1193807001048 dimer interface [polypeptide binding]; other site 1193807001049 substrate binding site [chemical binding]; other site 1193807001050 metal binding sites [ion binding]; metal-binding site 1193807001051 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1193807001052 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1193807001053 dimer interface [polypeptide binding]; other site 1193807001054 motif 1; other site 1193807001055 active site 1193807001056 motif 2; other site 1193807001057 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1193807001058 putative deacylase active site [active] 1193807001059 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1193807001060 active site 1193807001061 motif 3; other site 1193807001062 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1193807001063 anticodon binding site; other site 1193807001064 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1193807001065 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1193807001066 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1193807001067 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1193807001068 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1193807001069 active site 1193807001070 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1193807001071 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1193807001072 putative substrate binding region [chemical binding]; other site 1193807001073 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1193807001074 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1193807001075 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1193807001076 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1193807001077 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1193807001078 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1193807001079 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1193807001080 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1193807001081 catalytic residue [active] 1193807001082 putative FPP diphosphate binding site; other site 1193807001083 putative FPP binding hydrophobic cleft; other site 1193807001084 dimer interface [polypeptide binding]; other site 1193807001085 putative IPP diphosphate binding site; other site 1193807001086 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1193807001087 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1193807001088 hinge region; other site 1193807001089 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1193807001090 putative nucleotide binding site [chemical binding]; other site 1193807001091 uridine monophosphate binding site [chemical binding]; other site 1193807001092 homohexameric interface [polypeptide binding]; other site 1193807001093 elongation factor Ts; Reviewed; Region: tsf; PRK12332 1193807001094 UBA/TS-N domain; Region: UBA; pfam00627 1193807001095 Elongation factor TS; Region: EF_TS; pfam00889 1193807001096 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1193807001097 rRNA interaction site [nucleotide binding]; other site 1193807001098 S8 interaction site; other site 1193807001099 putative laminin-1 binding site; other site 1193807001100 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 1193807001101 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1193807001102 putative active site [active] 1193807001103 catalytic triad [active] 1193807001104 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 1193807001105 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 1193807001106 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 1193807001107 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1193807001108 dimerization interface [polypeptide binding]; other site 1193807001109 ATP binding site [chemical binding]; other site 1193807001110 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1193807001111 dimerization interface [polypeptide binding]; other site 1193807001112 ATP binding site [chemical binding]; other site 1193807001113 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1193807001114 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1193807001115 active site 1193807001116 multimer interface [polypeptide binding]; other site 1193807001117 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1193807001118 iron-sulfur cluster [ion binding]; other site 1193807001119 [2Fe-2S] cluster binding site [ion binding]; other site 1193807001120 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1193807001121 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1193807001122 active site 1193807001123 Predicted methyltransferases [General function prediction only]; Region: COG0313 1193807001124 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1193807001125 putative SAM binding site [chemical binding]; other site 1193807001126 putative homodimer interface [polypeptide binding]; other site 1193807001127 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1193807001128 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1193807001129 active site 1193807001130 HIGH motif; other site 1193807001131 KMSKS motif; other site 1193807001132 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1193807001133 tRNA binding surface [nucleotide binding]; other site 1193807001134 anticodon binding site; other site 1193807001135 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1193807001136 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1193807001137 substrate binding pocket [chemical binding]; other site 1193807001138 chain length determination region; other site 1193807001139 substrate-Mg2+ binding site; other site 1193807001140 catalytic residues [active] 1193807001141 aspartate-rich region 1; other site 1193807001142 active site lid residues [active] 1193807001143 aspartate-rich region 2; other site 1193807001144 FtsH Extracellular; Region: FtsH_ext; pfam06480 1193807001145 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1193807001146 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1193807001147 Walker A motif; other site 1193807001148 ATP binding site [chemical binding]; other site 1193807001149 Walker B motif; other site 1193807001150 arginine finger; other site 1193807001151 Peptidase family M41; Region: Peptidase_M41; pfam01434 1193807001152 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 1193807001153 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1193807001154 AP (apurinic/apyrimidinic) site pocket; other site 1193807001155 DNA interaction; other site 1193807001156 Metal-binding active site; metal-binding site 1193807001157 Oligomerisation domain; Region: Oligomerisation; pfam02410 1193807001158 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1193807001159 active site 1193807001160 multimer interface [polypeptide binding]; other site 1193807001161 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1193807001162 Glycoprotease family; Region: Peptidase_M22; pfam00814 1193807001163 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1193807001164 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1193807001165 motif II; other site 1193807001166 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1193807001167 thiamine monophosphate kinase; Provisional; Region: PRK05731 1193807001168 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1193807001169 ATP binding site [chemical binding]; other site 1193807001170 dimerization interface [polypeptide binding]; other site 1193807001171 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1193807001172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1193807001173 S-adenosylmethionine binding site [chemical binding]; other site 1193807001174 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1193807001175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1193807001176 S-adenosylmethionine binding site [chemical binding]; other site 1193807001177 2-deoxy-scyllo-inosose synthase (DOIS) catalyzes carbocycle formation from D-glucose-6-phosphate to 2-deoxy-scyllo-inosose through a multistep reaction in the biosynthesis of aminoglycoside antibiotics; Region: DOIS; cd08197 1193807001178 active site 1193807001179 dimer interface [polypeptide binding]; other site 1193807001180 metal binding site [ion binding]; metal-binding site 1193807001181 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 1193807001182 UbiA prenyltransferase family; Region: UbiA; pfam01040 1193807001183 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1193807001184 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1193807001185 S-adenosylmethionine binding site [chemical binding]; other site 1193807001186 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1193807001187 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1193807001188 active site 1193807001189 metal binding site [ion binding]; metal-binding site 1193807001190 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1193807001191 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1193807001192 S-adenosylmethionine binding site [chemical binding]; other site 1193807001193 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1193807001194 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1193807001195 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1193807001196 Rubrerythrin [Energy production and conversion]; Region: COG1592 1193807001197 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 1193807001198 binuclear metal center [ion binding]; other site 1193807001199 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 1193807001200 iron binding site [ion binding]; other site 1193807001201 Ion channel; Region: Ion_trans_2; pfam07885 1193807001202 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1193807001203 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 1193807001204 active site 1193807001205 NTP binding site [chemical binding]; other site 1193807001206 metal binding triad [ion binding]; metal-binding site 1193807001207 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1193807001208 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1193807001209 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1193807001210 Walker A/P-loop; other site 1193807001211 ATP binding site [chemical binding]; other site 1193807001212 Q-loop/lid; other site 1193807001213 ABC transporter signature motif; other site 1193807001214 Walker B; other site 1193807001215 D-loop; other site 1193807001216 H-loop/switch region; other site 1193807001217 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1193807001218 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1193807001219 hypothetical protein; Provisional; Region: PRK01184 1193807001220 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1193807001221 active site 1193807001222 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1193807001223 catalytic motif [active] 1193807001224 Zn binding site [ion binding]; other site 1193807001225 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1193807001226 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1193807001227 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1193807001228 trimer interface [polypeptide binding]; other site 1193807001229 active site 1193807001230 Probable zinc-binding domain; Region: zf-trcl; pfam13451 1193807001231 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 1193807001232 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1193807001233 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1193807001234 Walker A/P-loop; other site 1193807001235 ATP binding site [chemical binding]; other site 1193807001236 Q-loop/lid; other site 1193807001237 ABC transporter signature motif; other site 1193807001238 Walker B; other site 1193807001239 D-loop; other site 1193807001240 H-loop/switch region; other site 1193807001241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1193807001242 dimer interface [polypeptide binding]; other site 1193807001243 conserved gate region; other site 1193807001244 putative PBP binding loops; other site 1193807001245 ABC-ATPase subunit interface; other site 1193807001246 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1193807001247 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1193807001248 substrate binding pocket [chemical binding]; other site 1193807001249 membrane-bound complex binding site; other site 1193807001250 hinge residues; other site 1193807001251 EDD domain protein, DegV family; Region: DegV; TIGR00762 1193807001252 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1193807001253 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1193807001254 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 1193807001255 oligomer interface [polypeptide binding]; other site 1193807001256 metal binding site [ion binding]; metal-binding site 1193807001257 metal binding site [ion binding]; metal-binding site 1193807001258 putative Cl binding site [ion binding]; other site 1193807001259 aspartate ring; other site 1193807001260 basic sphincter; other site 1193807001261 hydrophobic gate; other site 1193807001262 periplasmic entrance; other site 1193807001263 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 1193807001264 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1193807001265 Uncharacterized conserved protein [Function unknown]; Region: COG1656 1193807001266 Protein of unknown function DUF82; Region: DUF82; pfam01927 1193807001267 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 1193807001268 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1193807001269 putative substrate binding site [chemical binding]; other site 1193807001270 putative ATP binding site [chemical binding]; other site 1193807001271 pantothenate kinase; Reviewed; Region: PRK13321 1193807001272 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1193807001273 Flavoprotein; Region: Flavoprotein; pfam02441 1193807001274 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1193807001275 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1193807001276 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1193807001277 active site 1193807001278 HIGH motif; other site 1193807001279 nucleotide binding site [chemical binding]; other site 1193807001280 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1193807001281 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1193807001282 active site 1193807001283 KMSKS motif; other site 1193807001284 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1193807001285 tRNA binding surface [nucleotide binding]; other site 1193807001286 anticodon binding site; other site 1193807001287 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1193807001288 PAS domain S-box; Region: sensory_box; TIGR00229 1193807001289 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1193807001290 putative active site [active] 1193807001291 heme pocket [chemical binding]; other site 1193807001292 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1193807001293 Histidine kinase; Region: HisKA_3; pfam07730 1193807001294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1193807001295 ATP binding site [chemical binding]; other site 1193807001296 Mg2+ binding site [ion binding]; other site 1193807001297 G-X-G motif; other site 1193807001298 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1193807001299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1193807001300 active site 1193807001301 phosphorylation site [posttranslational modification] 1193807001302 intermolecular recognition site; other site 1193807001303 dimerization interface [polypeptide binding]; other site 1193807001304 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1193807001305 DNA binding residues [nucleotide binding] 1193807001306 dimerization interface [polypeptide binding]; other site 1193807001307 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1193807001308 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1193807001309 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1193807001310 nucleotide binding region [chemical binding]; other site 1193807001311 ATP-binding site [chemical binding]; other site 1193807001312 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1193807001313 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1193807001314 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1193807001315 active site 1193807001316 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1193807001317 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1193807001318 dimer interface [polypeptide binding]; other site 1193807001319 active site 1193807001320 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1193807001321 folate binding site [chemical binding]; other site 1193807001322 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1193807001323 Fe-S cluster binding site [ion binding]; other site 1193807001324 active site 1193807001325 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1193807001326 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1193807001327 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1193807001328 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1193807001329 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1193807001330 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1193807001331 excinuclease ABC subunit B; Provisional; Region: PRK05298 1193807001332 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1193807001333 ATP binding site [chemical binding]; other site 1193807001334 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1193807001335 nucleotide binding region [chemical binding]; other site 1193807001336 ATP-binding site [chemical binding]; other site 1193807001337 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1193807001338 UvrB/uvrC motif; Region: UVR; pfam02151 1193807001339 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14605 1193807001340 RuvA N terminal domain; Region: RuvA_N; pfam01330 1193807001341 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1193807001342 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1193807001343 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1193807001344 active site 1193807001345 putative DNA-binding cleft [nucleotide binding]; other site 1193807001346 dimer interface [polypeptide binding]; other site 1193807001347 hypothetical protein; Validated; Region: PRK00110 1193807001348 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1193807001349 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 1193807001350 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1193807001351 putative dimer interface [polypeptide binding]; other site 1193807001352 [2Fe-2S] cluster binding site [ion binding]; other site 1193807001353 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1193807001354 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1193807001355 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1193807001356 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 1193807001357 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1193807001358 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1193807001359 substrate binding site [chemical binding]; other site 1193807001360 ligand binding site [chemical binding]; other site 1193807001361 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 1193807001362 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1193807001363 substrate binding site [chemical binding]; other site 1193807001364 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1193807001365 isocitrate dehydrogenase; Validated; Region: PRK07362 1193807001366 malate dehydrogenase; Reviewed; Region: PRK06223 1193807001367 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1193807001368 NAD(P) binding site [chemical binding]; other site 1193807001369 dimer interface [polypeptide binding]; other site 1193807001370 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1193807001371 substrate binding site [chemical binding]; other site 1193807001372 fumarate hydratase; Provisional; Region: PRK06246 1193807001373 Fumarase C-terminus; Region: Fumerase_C; cl00795 1193807001374 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1193807001375 nucleotide binding site/active site [active] 1193807001376 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1193807001377 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1193807001378 dimer interface [polypeptide binding]; other site 1193807001379 ADP-ribose binding site [chemical binding]; other site 1193807001380 active site 1193807001381 nudix motif; other site 1193807001382 metal binding site [ion binding]; metal-binding site 1193807001383 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1193807001384 Coenzyme A binding pocket [chemical binding]; other site 1193807001385 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 1193807001386 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1193807001387 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 1193807001388 arogenate dehydrogenase; Region: PLN02256 1193807001389 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1193807001390 Chorismate mutase type II; Region: CM_2; smart00830 1193807001391 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1193807001392 Prephenate dehydratase; Region: PDT; pfam00800 1193807001393 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1193807001394 putative L-Phe binding site [chemical binding]; other site 1193807001395 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1193807001396 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1193807001397 Tetramer interface [polypeptide binding]; other site 1193807001398 active site 1193807001399 FMN-binding site [chemical binding]; other site 1193807001400 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1193807001401 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1193807001402 hinge; other site 1193807001403 active site 1193807001404 shikimate kinase; Reviewed; Region: aroK; PRK00131 1193807001405 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1193807001406 ADP binding site [chemical binding]; other site 1193807001407 magnesium binding site [ion binding]; other site 1193807001408 putative shikimate binding site; other site 1193807001409 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1193807001410 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1193807001411 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1193807001412 shikimate binding site; other site 1193807001413 NAD(P) binding site [chemical binding]; other site 1193807001414 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1193807001415 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1193807001416 active site 1193807001417 catalytic residue [active] 1193807001418 dimer interface [polypeptide binding]; other site 1193807001419 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1193807001420 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1193807001421 active site 1193807001422 dimer interface [polypeptide binding]; other site 1193807001423 metal binding site [ion binding]; metal-binding site 1193807001424 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 1193807001425 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 1193807001426 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1193807001427 S17 interaction site [polypeptide binding]; other site 1193807001428 S8 interaction site; other site 1193807001429 16S rRNA interaction site [nucleotide binding]; other site 1193807001430 streptomycin interaction site [chemical binding]; other site 1193807001431 23S rRNA interaction site [nucleotide binding]; other site 1193807001432 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1193807001433 30S ribosomal protein S7; Validated; Region: PRK05302 1193807001434 elongation factor G; Reviewed; Region: PRK12739 1193807001435 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1193807001436 G1 box; other site 1193807001437 putative GEF interaction site [polypeptide binding]; other site 1193807001438 GTP/Mg2+ binding site [chemical binding]; other site 1193807001439 Switch I region; other site 1193807001440 G2 box; other site 1193807001441 G3 box; other site 1193807001442 Switch II region; other site 1193807001443 G4 box; other site 1193807001444 G5 box; other site 1193807001445 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1193807001446 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1193807001447 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1193807001448 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1193807001449 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 1193807001450 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1193807001451 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1193807001452 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1193807001453 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1193807001454 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1193807001455 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1193807001456 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1193807001457 putative translocon binding site; other site 1193807001458 protein-rRNA interface [nucleotide binding]; other site 1193807001459 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1193807001460 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1193807001461 G-X-X-G motif; other site 1193807001462 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1193807001463 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1193807001464 23S rRNA interface [nucleotide binding]; other site 1193807001465 5S rRNA interface [nucleotide binding]; other site 1193807001466 putative antibiotic binding site [chemical binding]; other site 1193807001467 L25 interface [polypeptide binding]; other site 1193807001468 L27 interface [polypeptide binding]; other site 1193807001469 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1193807001470 23S rRNA interface [nucleotide binding]; other site 1193807001471 putative translocon interaction site; other site 1193807001472 signal recognition particle (SRP54) interaction site; other site 1193807001473 L23 interface [polypeptide binding]; other site 1193807001474 trigger factor interaction site; other site 1193807001475 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1193807001476 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1193807001477 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1193807001478 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1193807001479 RNA binding site [nucleotide binding]; other site 1193807001480 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1193807001481 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1193807001482 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1193807001483 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1193807001484 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1193807001485 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1193807001486 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1193807001487 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1193807001488 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1193807001489 5S rRNA interface [nucleotide binding]; other site 1193807001490 L27 interface [polypeptide binding]; other site 1193807001491 23S rRNA interface [nucleotide binding]; other site 1193807001492 L5 interface [polypeptide binding]; other site 1193807001493 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1193807001494 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1193807001495 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1193807001496 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1193807001497 23S rRNA binding site [nucleotide binding]; other site 1193807001498 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1193807001499 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1193807001500 SecY translocase; Region: SecY; pfam00344 1193807001501 adenylate kinase; Reviewed; Region: adk; PRK00279 1193807001502 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1193807001503 AMP-binding site [chemical binding]; other site 1193807001504 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1193807001505 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1193807001506 active site 1193807001507 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1193807001508 rRNA binding site [nucleotide binding]; other site 1193807001509 predicted 30S ribosome binding site; other site 1193807001510 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1193807001511 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1193807001512 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1193807001513 30S ribosomal protein S11; Validated; Region: PRK05309 1193807001514 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1193807001515 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1193807001516 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1193807001517 RNA binding surface [nucleotide binding]; other site 1193807001518 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1193807001519 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1193807001520 alphaNTD - beta interaction site [polypeptide binding]; other site 1193807001521 alphaNTD homodimer interface [polypeptide binding]; other site 1193807001522 alphaNTD - beta' interaction site [polypeptide binding]; other site 1193807001523 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1193807001524 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1193807001525 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1193807001526 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1193807001527 dimerization interface 3.5A [polypeptide binding]; other site 1193807001528 active site 1193807001529 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1193807001530 23S rRNA interface [nucleotide binding]; other site 1193807001531 L3 interface [polypeptide binding]; other site 1193807001532 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1193807001533 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 1193807001534 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_1; cd05017 1193807001535 dimer interface [polypeptide binding]; other site 1193807001536 active site 1193807001537 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 1193807001538 dimer interface [polypeptide binding]; other site 1193807001539 active site 1193807001540 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 1193807001541 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1193807001542 active site 1193807001543 substrate binding site [chemical binding]; other site 1193807001544 metal binding site [ion binding]; metal-binding site 1193807001545 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1193807001546 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1193807001547 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1193807001548 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1193807001549 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1193807001550 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1193807001551 homotetramer interface [polypeptide binding]; other site 1193807001552 ligand binding site [chemical binding]; other site 1193807001553 catalytic site [active] 1193807001554 NAD binding site [chemical binding]; other site 1193807001555 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1193807001556 Predicted kinase [General function prediction only]; Region: COG0645 1193807001557 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1193807001558 ATP-binding site [chemical binding]; other site 1193807001559 Gluconate-6-phosphate binding site [chemical binding]; other site 1193807001560 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 1193807001561 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1193807001562 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 1193807001563 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1193807001564 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1193807001565 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1193807001566 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1193807001567 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1193807001568 Walker A/P-loop; other site 1193807001569 ATP binding site [chemical binding]; other site 1193807001570 Q-loop/lid; other site 1193807001571 ABC transporter signature motif; other site 1193807001572 Walker B; other site 1193807001573 D-loop; other site 1193807001574 H-loop/switch region; other site 1193807001575 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 1193807001576 active site 2 [active] 1193807001577 active site 1 [active] 1193807001578 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1193807001579 active site 1193807001580 catalytic site [active] 1193807001581 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1193807001582 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1193807001583 HEAT repeats; Region: HEAT_2; pfam13646 1193807001584 HEAT repeats; Region: HEAT_2; pfam13646 1193807001585 PAC2 family; Region: PAC2; pfam09754 1193807001586 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1193807001587 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1193807001588 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 1193807001589 This archaeal PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar...; Region: PGM_like1; cd03087 1193807001590 active site 1193807001591 substrate binding site [chemical binding]; other site 1193807001592 metal binding site [ion binding]; metal-binding site 1193807001593 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: Arch_glmU; TIGR03992 1193807001594 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1193807001595 active site 1193807001596 Substrate binding site; other site 1193807001597 Mg++ binding site; other site 1193807001598 Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636 1193807001599 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: Arch_glmU; TIGR03992 1193807001600 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1193807001601 active site 1193807001602 Substrate binding site; other site 1193807001603 Mg++ binding site; other site 1193807001604 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1193807001605 putative trimer interface [polypeptide binding]; other site 1193807001606 putative CoA binding site [chemical binding]; other site 1193807001607 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1193807001608 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1193807001609 glutaminase active site [active] 1193807001610 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1193807001611 dimer interface [polypeptide binding]; other site 1193807001612 active site 1193807001613 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1193807001614 dimer interface [polypeptide binding]; other site 1193807001615 active site 1193807001616 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1193807001617 substrate binding site [chemical binding]; other site 1193807001618 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1193807001619 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1193807001620 motif II; other site 1193807001621 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1193807001622 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1193807001623 active site 1193807001624 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1193807001625 substrate binding site [chemical binding]; other site 1193807001626 catalytic residues [active] 1193807001627 dimer interface [polypeptide binding]; other site 1193807001628 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1193807001629 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 1193807001630 Walker A motif; other site 1193807001631 ATP binding site [chemical binding]; other site 1193807001632 Walker B motif; other site 1193807001633 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 1193807001634 arginine finger; other site 1193807001635 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1193807001636 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1193807001637 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1193807001638 active site 1193807001639 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1193807001640 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1193807001641 Walker A motif; other site 1193807001642 ATP binding site [chemical binding]; other site 1193807001643 Walker B motif; other site 1193807001644 arginine finger; other site 1193807001645 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1193807001646 Walker A motif; other site 1193807001647 ATP binding site [chemical binding]; other site 1193807001648 Walker B motif; other site 1193807001649 arginine finger; other site 1193807001650 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1193807001651 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1193807001652 replicative DNA helicase; Region: DnaB; TIGR00665 1193807001653 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1193807001654 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1193807001655 Walker A motif; other site 1193807001656 ATP binding site [chemical binding]; other site 1193807001657 Walker B motif; other site 1193807001658 DNA binding loops [nucleotide binding] 1193807001659 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1193807001660 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1193807001661 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1193807001662 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1193807001663 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1193807001664 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1193807001665 putative phosphate acyltransferase; Provisional; Region: PRK05331 1193807001666 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1193807001667 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1193807001668 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1193807001669 metal binding site [ion binding]; metal-binding site 1193807001670 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1193807001671 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1193807001672 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1193807001673 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1193807001674 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1193807001675 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1193807001676 non-specific DNA binding site [nucleotide binding]; other site 1193807001677 salt bridge; other site 1193807001678 sequence-specific DNA binding site [nucleotide binding]; other site 1193807001679 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1193807001680 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1193807001681 Walker A/P-loop; other site 1193807001682 ATP binding site [chemical binding]; other site 1193807001683 Q-loop/lid; other site 1193807001684 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1193807001685 ABC transporter signature motif; other site 1193807001686 Walker B; other site 1193807001687 D-loop; other site 1193807001688 H-loop/switch region; other site 1193807001689 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1193807001690 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 1193807001691 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1193807001692 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1193807001693 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1193807001694 DNA binding residues [nucleotide binding] 1193807001695 DNA primase; Validated; Region: dnaG; PRK05667 1193807001696 CHC2 zinc finger; Region: zf-CHC2; cl17510 1193807001697 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1193807001698 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1193807001699 active site 1193807001700 metal binding site [ion binding]; metal-binding site 1193807001701 interdomain interaction site; other site 1193807001702 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1193807001703 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 1193807001704 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1193807001705 Zn2+ binding site [ion binding]; other site 1193807001706 Mg2+ binding site [ion binding]; other site 1193807001707 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1193807001708 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1193807001709 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1193807001710 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1193807001711 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1193807001712 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1193807001713 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 1193807001714 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1193807001715 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1193807001716 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 1193807001717 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1193807001718 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1193807001719 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1193807001720 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 1193807001721 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1193807001722 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1193807001723 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1193807001724 beta subunit interaction interface [polypeptide binding]; other site 1193807001725 Walker A motif; other site 1193807001726 ATP binding site [chemical binding]; other site 1193807001727 Walker B motif; other site 1193807001728 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1193807001729 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1193807001730 core domain interface [polypeptide binding]; other site 1193807001731 delta subunit interface [polypeptide binding]; other site 1193807001732 epsilon subunit interface [polypeptide binding]; other site 1193807001733 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1193807001734 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1193807001735 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1193807001736 alpha subunit interaction interface [polypeptide binding]; other site 1193807001737 Walker A motif; other site 1193807001738 ATP binding site [chemical binding]; other site 1193807001739 Walker B motif; other site 1193807001740 inhibitor binding site; inhibition site 1193807001741 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1193807001742 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1193807001743 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1193807001744 gamma subunit interface [polypeptide binding]; other site 1193807001745 LBP interface [polypeptide binding]; other site 1193807001746 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1193807001747 RimM N-terminal domain; Region: RimM; pfam01782 1193807001748 PRC-barrel domain; Region: PRC; pfam05239 1193807001749 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1193807001750 KH domain; Region: KH_4; pfam13083 1193807001751 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1193807001752 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1193807001753 Active_site [active] 1193807001754 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1193807001755 PCRF domain; Region: PCRF; pfam03462 1193807001756 RF-1 domain; Region: RF-1; pfam00472 1193807001757 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1193807001758 hypothetical protein; Reviewed; Region: PRK00024 1193807001759 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1193807001760 helix-hairpin-helix signature motif; other site 1193807001761 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1193807001762 MPN+ (JAMM) motif; other site 1193807001763 substrate binding pocket [chemical binding]; other site 1193807001764 Zinc-binding site [ion binding]; other site 1193807001765 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1193807001766 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1193807001767 peptide binding site [polypeptide binding]; other site 1193807001768 transaminase; Validated; Region: PRK07324 1193807001769 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1193807001770 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1193807001771 homodimer interface [polypeptide binding]; other site 1193807001772 catalytic residue [active] 1193807001773 seryl-tRNA synthetase; Provisional; Region: PRK05431 1193807001774 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1193807001775 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1193807001776 dimer interface [polypeptide binding]; other site 1193807001777 active site 1193807001778 motif 1; other site 1193807001779 motif 2; other site 1193807001780 motif 3; other site 1193807001781 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1193807001782 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1193807001783 dimer interface [polypeptide binding]; other site 1193807001784 putative anticodon binding site; other site 1193807001785 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1193807001786 motif 1; other site 1193807001787 active site 1193807001788 motif 2; other site 1193807001789 motif 3; other site 1193807001790 Recombination protein O N terminal; Region: RecO_N; pfam11967 1193807001791 DNA repair protein RecO; Region: reco; TIGR00613 1193807001792 Recombination protein O C terminal; Region: RecO_C; pfam02565 1193807001793 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1193807001794 A new structural DNA glycosylase; Region: AlkD_like; cd06561 1193807001795 active site 1193807001796 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1193807001797 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 1193807001798 oligomer interface [polypeptide binding]; other site 1193807001799 metal binding site [ion binding]; metal-binding site 1193807001800 metal binding site [ion binding]; metal-binding site 1193807001801 Cl binding site [ion binding]; other site 1193807001802 aspartate ring; other site 1193807001803 basic sphincter; other site 1193807001804 putative hydrophobic gate; other site 1193807001805 periplasmic entrance; other site 1193807001806 recombination protein RecR; Reviewed; Region: recR; PRK00076 1193807001807 RecR protein; Region: RecR; pfam02132 1193807001808 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1193807001809 putative active site [active] 1193807001810 putative metal-binding site [ion binding]; other site 1193807001811 tetramer interface [polypeptide binding]; other site 1193807001812 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1193807001813 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 1193807001814 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1193807001815 Walker A motif; other site 1193807001816 ATP binding site [chemical binding]; other site 1193807001817 Walker B motif; other site 1193807001818 arginine finger; other site 1193807001819 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1193807001820 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 1193807001821 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 1193807001822 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1193807001823 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type2; cd02202 1193807001824 Tubulin/FtsZ family, GTPase domain; Region: Tubulin; pfam00091 1193807001825 nucleotide binding site [chemical binding]; other site 1193807001826 SulA interaction site; other site 1193807001827 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1193807001828 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1193807001829 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1193807001830 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 1193807001831 enolase; Provisional; Region: eno; PRK00077 1193807001832 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1193807001833 dimer interface [polypeptide binding]; other site 1193807001834 metal binding site [ion binding]; metal-binding site 1193807001835 substrate binding pocket [chemical binding]; other site 1193807001836 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1193807001837 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1193807001838 putative active site [active] 1193807001839 catalytic residue [active] 1193807001840 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1193807001841 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1193807001842 nucleotide binding pocket [chemical binding]; other site 1193807001843 K-X-D-G motif; other site 1193807001844 catalytic site [active] 1193807001845 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1193807001846 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1193807001847 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1193807001848 Dimer interface [polypeptide binding]; other site 1193807001849 Uncharacterized conserved protein [Function unknown]; Region: COG4198 1193807001850 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 1193807001851 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1193807001852 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 1193807001853 predicted active site [active] 1193807001854 catalytic triad [active] 1193807001855 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1193807001856 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1193807001857 ligand binding site [chemical binding]; other site 1193807001858 NAD binding site [chemical binding]; other site 1193807001859 dimerization interface [polypeptide binding]; other site 1193807001860 catalytic site [active] 1193807001861 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1193807001862 putative L-serine binding site [chemical binding]; other site 1193807001863 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 1193807001864 homodimer interface [polypeptide binding]; other site 1193807001865 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1193807001866 catalytic residue [active] 1193807001867 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1193807001868 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1193807001869 active site 1193807001870 HIGH motif; other site 1193807001871 dimer interface [polypeptide binding]; other site 1193807001872 KMSKS motif; other site 1193807001873 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1193807001874 RNA binding surface [nucleotide binding]; other site 1193807001875 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1193807001876 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1193807001877 active site 1193807001878 Riboflavin kinase; Region: Flavokinase; pfam01687 1193807001879 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1193807001880 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1193807001881 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1193807001882 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1193807001883 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 1193807001884 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1193807001885 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1193807001886 RPB10 interaction site [polypeptide binding]; other site 1193807001887 RPB11 interaction site [polypeptide binding]; other site 1193807001888 RPB3 interaction site [polypeptide binding]; other site 1193807001889 RPB12 interaction site [polypeptide binding]; other site 1193807001890 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1193807001891 RPB1 interaction site [polypeptide binding]; other site 1193807001892 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 1193807001893 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1193807001894 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1193807001895 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1193807001896 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1193807001897 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1193807001898 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1193807001899 cleft; other site 1193807001900 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1193807001901 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 1193807001902 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1193807001903 DNA binding site [nucleotide binding] 1193807001904 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1193807001905 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1193807001906 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1193807001907 Walker A motif; other site 1193807001908 ATP binding site [chemical binding]; other site 1193807001909 Walker B motif; other site 1193807001910 arginine finger; other site 1193807001911 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1193807001912 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 1193807001913 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1193807001914 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1193807001915 Coenzyme A binding pocket [chemical binding]; other site 1193807001916 Predicted permease; Region: DUF318; cl17795 1193807001917 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1193807001918 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1193807001919 S-adenosylmethionine binding site [chemical binding]; other site 1193807001920 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1193807001921 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1193807001922 FeS/SAM binding site; other site 1193807001923 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1193807001924 Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941 1193807001925 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1193807001926 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 1193807001927 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 1193807001928 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1193807001929 Endopeptidases belonging to F420-reducing hydrogenases group. These hydrogenases from methanogens are encoded by the fru, frc, or frh genes. Sequence comparison indicates that fruD and frcD gene products from Methanococcus voltae are similar to HycI...; Region: H2MP_F420-Reduc; cd06064 1193807001930 nickel binding site [ion binding]; other site 1193807001931 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1193807001932 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1193807001933 catalytic residues [active] 1193807001934 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1193807001935 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1193807001936 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1193807001937 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1193807001938 FeS/SAM binding site; other site 1193807001939 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1193807001940 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1193807001941 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 1193807001942 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1193807001943 active site 1193807001944 effector binding site; other site 1193807001945 dimer interface [polypeptide binding]; other site 1193807001946 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1193807001947 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1193807001948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1193807001949 active site 1193807001950 phosphorylation site [posttranslational modification] 1193807001951 intermolecular recognition site; other site 1193807001952 dimerization interface [polypeptide binding]; other site 1193807001953 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1193807001954 Zn2+ binding site [ion binding]; other site 1193807001955 Mg2+ binding site [ion binding]; other site 1193807001956 PAS domain; Region: PAS_9; pfam13426 1193807001957 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1193807001958 putative active site [active] 1193807001959 heme pocket [chemical binding]; other site 1193807001960 PAS domain S-box; Region: sensory_box; TIGR00229 1193807001961 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1193807001962 putative active site [active] 1193807001963 heme pocket [chemical binding]; other site 1193807001964 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1193807001965 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1193807001966 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1193807001967 putative active site [active] 1193807001968 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1193807001969 phosphorylation site [posttranslational modification] 1193807001970 dimer interface [polypeptide binding]; other site 1193807001971 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1193807001972 ATP binding site [chemical binding]; other site 1193807001973 Mg2+ binding site [ion binding]; other site 1193807001974 G-X-G motif; other site 1193807001975 Flagellin N-methylase; Region: FliB; cl00497 1193807001976 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1193807001977 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1193807001978 FeS/SAM binding site; other site 1193807001979 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1193807001980 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1193807001981 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1193807001982 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1193807001983 metal binding site 2 [ion binding]; metal-binding site 1193807001984 putative DNA binding helix; other site 1193807001985 metal binding site 1 [ion binding]; metal-binding site 1193807001986 dimer interface [polypeptide binding]; other site 1193807001987 structural Zn2+ binding site [ion binding]; other site 1193807001988 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 1193807001989 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1193807001990 putative metal binding residues [ion binding]; other site 1193807001991 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1193807001992 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1193807001993 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1193807001994 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1193807001995 ABC-ATPase subunit interface; other site 1193807001996 dimer interface [polypeptide binding]; other site 1193807001997 putative PBP binding regions; other site 1193807001998 cell division protein FtsZ; Validated; Region: PRK09330 1193807001999 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1193807002000 nucleotide binding site [chemical binding]; other site 1193807002001 SulA interaction site; other site 1193807002002 cell division protein FtsA; Region: ftsA; TIGR01174 1193807002003 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1193807002004 nucleotide binding site [chemical binding]; other site 1193807002005 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 1193807002006 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1193807002007 Cell division protein FtsA; Region: FtsA; pfam14450 1193807002008 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1193807002009 Ligand Binding Site [chemical binding]; other site 1193807002010 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1193807002011 Ligand Binding Site [chemical binding]; other site 1193807002012 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1193807002013 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1193807002014 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1193807002015 substrate binding site [chemical binding]; other site 1193807002016 hexamer interface [polypeptide binding]; other site 1193807002017 metal binding site [ion binding]; metal-binding site 1193807002018 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1193807002019 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1193807002020 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1193807002021 TPP-binding site [chemical binding]; other site 1193807002022 dimer interface [polypeptide binding]; other site 1193807002023 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1193807002024 PYR/PP interface [polypeptide binding]; other site 1193807002025 dimer interface [polypeptide binding]; other site 1193807002026 TPP binding site [chemical binding]; other site 1193807002027 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1193807002028 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1193807002029 putative FMN binding site [chemical binding]; other site 1193807002030 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1193807002031 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1193807002032 S-adenosylmethionine binding site [chemical binding]; other site 1193807002033 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1193807002034 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1193807002035 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1193807002036 cobalamin binding residues [chemical binding]; other site 1193807002037 putative BtuC binding residues; other site 1193807002038 dimer interface [polypeptide binding]; other site 1193807002039 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1193807002040 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1193807002041 ABC-ATPase subunit interface; other site 1193807002042 dimer interface [polypeptide binding]; other site 1193807002043 putative PBP binding regions; other site 1193807002044 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1193807002045 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1193807002046 Walker A/P-loop; other site 1193807002047 ATP binding site [chemical binding]; other site 1193807002048 Q-loop/lid; other site 1193807002049 ABC transporter signature motif; other site 1193807002050 Walker B; other site 1193807002051 D-loop; other site 1193807002052 H-loop/switch region; other site 1193807002053 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 1193807002054 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 1193807002055 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1193807002056 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1193807002057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1193807002058 homodimer interface [polypeptide binding]; other site 1193807002059 catalytic residue [active] 1193807002060 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1193807002061 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1193807002062 putative dimer interface [polypeptide binding]; other site 1193807002063 active site pocket [active] 1193807002064 putative cataytic base [active] 1193807002065 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1193807002066 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1193807002067 catalytic core [active] 1193807002068 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1193807002069 homotrimer interface [polypeptide binding]; other site 1193807002070 Walker A motif; other site 1193807002071 GTP binding site [chemical binding]; other site 1193807002072 Walker B motif; other site 1193807002073 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1193807002074 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1193807002075 catalytic residues [active] 1193807002076 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1193807002077 Histidine kinase; Region: HisKA_3; pfam07730 1193807002078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1193807002079 ATP binding site [chemical binding]; other site 1193807002080 Mg2+ binding site [ion binding]; other site 1193807002081 G-X-G motif; other site 1193807002082 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1193807002083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1193807002084 active site 1193807002085 phosphorylation site [posttranslational modification] 1193807002086 intermolecular recognition site; other site 1193807002087 dimerization interface [polypeptide binding]; other site 1193807002088 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1193807002089 DNA binding residues [nucleotide binding] 1193807002090 dimerization interface [polypeptide binding]; other site 1193807002091 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 1193807002092 acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional; Region: PRK04165 1193807002093 Putative Fe-S cluster; Region: FeS; pfam04060 1193807002094 bifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta; Reviewed; Region: PRK09529 1193807002095 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1193807002096 ACS interaction site; other site 1193807002097 CODH interaction site; other site 1193807002098 metal cluster binding site [ion binding]; other site 1193807002099 CO dehydrogenase/acetyl-CoA synthase complex beta subunit; Region: CdhC; pfam03598 1193807002100 acetyl-CoA decarbonylase/synthase complex subunit delta; Provisional; Region: PRK04452 1193807002101 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1193807002102 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1193807002103 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1193807002104 homodimer interface [polypeptide binding]; other site 1193807002105 NADP binding site [chemical binding]; other site 1193807002106 substrate binding site [chemical binding]; other site 1193807002107 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 1193807002108 P-loop; other site 1193807002109 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 1193807002110 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 1193807002111 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1193807002112 catalytic loop [active] 1193807002113 iron binding site [ion binding]; other site 1193807002114 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1193807002115 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1193807002116 Potassium binding sites [ion binding]; other site 1193807002117 Cesium cation binding sites [ion binding]; other site 1193807002118 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1193807002119 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1193807002120 dimer interface [polypeptide binding]; other site 1193807002121 anticodon binding site; other site 1193807002122 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1193807002123 motif 1; other site 1193807002124 dimer interface [polypeptide binding]; other site 1193807002125 active site 1193807002126 motif 2; other site 1193807002127 GAD domain; Region: GAD; pfam02938 1193807002128 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1193807002129 active site 1193807002130 motif 3; other site 1193807002131 trigger factor; Region: tig; TIGR00115 1193807002132 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1193807002133 Clp protease; Region: CLP_protease; pfam00574 1193807002134 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1193807002135 oligomer interface [polypeptide binding]; other site 1193807002136 active site residues [active] 1193807002137 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1193807002138 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1193807002139 substrate binding site [chemical binding]; other site 1193807002140 ATP binding site [chemical binding]; other site 1193807002141 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 1193807002142 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1193807002143 substrate binding site [chemical binding]; other site 1193807002144 active site 1193807002145 cosubstrate binding site; other site 1193807002146 catalytic site [active] 1193807002147 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1193807002148 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 1193807002149 active site 1193807002150 PHP-associated; Region: PHP_C; pfam13263 1193807002151 translation elongation factor P; Region: efp; TIGR00038 1193807002152 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1193807002153 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1193807002154 RNA binding site [nucleotide binding]; other site 1193807002155 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1193807002156 RNA binding site [nucleotide binding]; other site 1193807002157 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1193807002158 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1193807002159 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1193807002160 active site 1193807002161 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1193807002162 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1193807002163 active site 1193807002164 Int/Topo IB signature motif; other site 1193807002165 DNA topoisomerase I; Validated; Region: PRK05582 1193807002166 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1193807002167 active site 1193807002168 interdomain interaction site; other site 1193807002169 putative metal-binding site [ion binding]; other site 1193807002170 nucleotide binding site [chemical binding]; other site 1193807002171 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1193807002172 domain I; other site 1193807002173 DNA binding groove [nucleotide binding] 1193807002174 phosphate binding site [ion binding]; other site 1193807002175 domain II; other site 1193807002176 domain III; other site 1193807002177 nucleotide binding site [chemical binding]; other site 1193807002178 catalytic site [active] 1193807002179 domain IV; other site 1193807002180 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1193807002181 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1193807002182 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1193807002183 DNA protecting protein DprA; Region: dprA; TIGR00732 1193807002184 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1193807002185 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1193807002186 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 1193807002187 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; Region: PorC_KorC; TIGR02175 1193807002188 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1193807002189 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179 1193807002190 pyruvate ferredoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK08367 1193807002191 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1193807002192 dimer interface [polypeptide binding]; other site 1193807002193 PYR/PP interface [polypeptide binding]; other site 1193807002194 TPP binding site [chemical binding]; other site 1193807002195 substrate binding site [chemical binding]; other site 1193807002196 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1193807002197 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 1193807002198 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 1193807002199 TPP-binding site [chemical binding]; other site 1193807002200 putative dimer interface [polypeptide binding]; other site 1193807002201 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 1193807002202 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1193807002203 putative dimer interface [polypeptide binding]; other site 1193807002204 [2Fe-2S] cluster binding site [ion binding]; other site 1193807002205 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1193807002206 dimer interface [polypeptide binding]; other site 1193807002207 [2Fe-2S] cluster binding site [ion binding]; other site 1193807002208 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1193807002209 SLBB domain; Region: SLBB; pfam10531 1193807002210 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1193807002211 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1193807002212 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1193807002213 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1193807002214 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 1193807002215 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1193807002216 4Fe-4S binding domain; Region: Fer4; cl02805 1193807002217 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1193807002218 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 1193807002219 Moco binding site; other site 1193807002220 metal coordination site [ion binding]; other site 1193807002221 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1193807002222 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1193807002223 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1193807002224 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1193807002225 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 1193807002226 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1193807002227 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1193807002228 NAD(P) binding site [chemical binding]; other site 1193807002229 active site 1193807002230 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1193807002231 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1193807002232 HflX GTPase family; Region: HflX; cd01878 1193807002233 G1 box; other site 1193807002234 GTP/Mg2+ binding site [chemical binding]; other site 1193807002235 Switch I region; other site 1193807002236 G2 box; other site 1193807002237 G3 box; other site 1193807002238 Switch II region; other site 1193807002239 G4 box; other site 1193807002240 G5 box; other site 1193807002241 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 1193807002242 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1193807002243 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1193807002244 homodimer interface [polypeptide binding]; other site 1193807002245 catalytic residue [active] 1193807002246 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1193807002247 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1193807002248 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1193807002249 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1193807002250 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1193807002251 triosephosphate isomerase; Provisional; Region: PRK14565 1193807002252 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1193807002253 substrate binding site [chemical binding]; other site 1193807002254 dimer interface [polypeptide binding]; other site 1193807002255 catalytic triad [active] 1193807002256 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04135 1193807002257 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1193807002258 Phosphoglycerate kinase; Region: PGK; pfam00162 1193807002259 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1193807002260 substrate binding site [chemical binding]; other site 1193807002261 hinge regions; other site 1193807002262 ADP binding site [chemical binding]; other site 1193807002263 catalytic site [active] 1193807002264 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1193807002265 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1193807002266 TPP-binding site; other site 1193807002267 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1193807002268 PYR/PP interface [polypeptide binding]; other site 1193807002269 dimer interface [polypeptide binding]; other site 1193807002270 TPP binding site [chemical binding]; other site 1193807002271 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1193807002272 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 1193807002273 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1193807002274 GAF domain; Region: GAF; pfam01590 1193807002275 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1193807002276 active site 1193807002277 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1193807002278 23S rRNA binding site [nucleotide binding]; other site 1193807002279 L21 binding site [polypeptide binding]; other site 1193807002280 L13 binding site [polypeptide binding]; other site 1193807002281 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1193807002282 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1193807002283 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1193807002284 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1193807002285 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1193807002286 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1193807002287 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1193807002288 active site 1193807002289 dimer interface [polypeptide binding]; other site 1193807002290 motif 1; other site 1193807002291 motif 2; other site 1193807002292 motif 3; other site 1193807002293 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1193807002294 anticodon binding site; other site 1193807002295 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1193807002296 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1193807002297 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1193807002298 catalytic residue [active] 1193807002299 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1193807002300 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1193807002301 active site 1193807002302 catalytic residues [active] 1193807002303 metal binding site [ion binding]; metal-binding site 1193807002304 Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945 1193807002305 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1193807002306 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 1193807002307 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 1193807002308 Predicted membrane protein [Function unknown]; Region: COG4818 1193807002309 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 1193807002310 Peptidase family M50; Region: Peptidase_M50; pfam02163 1193807002311 active site 1193807002312 putative substrate binding region [chemical binding]; other site 1193807002313 FOG: CBS domain [General function prediction only]; Region: COG0517 1193807002314 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 1193807002315 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1193807002316 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1193807002317 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1193807002318 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1193807002319 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1193807002320 CAAX protease self-immunity; Region: Abi; pfam02517 1193807002321 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 1193807002322 Peptidase family M50; Region: Peptidase_M50; pfam02163 1193807002323 active site 1193807002324 putative substrate binding region [chemical binding]; other site 1193807002325 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1193807002326 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 1193807002327 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 1193807002328 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1193807002329 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1193807002330 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 1193807002331 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1193807002332 Walker A motif; other site 1193807002333 ATP binding site [chemical binding]; other site 1193807002334 Walker B motif; other site 1193807002335 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 1193807002336 RxxxH motif; other site 1193807002337 thymidylate kinase; Validated; Region: tmk; PRK00698 1193807002338 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1193807002339 TMP-binding site; other site 1193807002340 ATP-binding site [chemical binding]; other site 1193807002341 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1193807002342 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1193807002343 Ligand Binding Site [chemical binding]; other site 1193807002344 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1193807002345 RNA/DNA hybrid binding site [nucleotide binding]; other site 1193807002346 active site 1193807002347 hypothetical protein; Provisional; Region: PRK14688 1193807002348 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 1193807002349 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1193807002350 thiamine phosphate binding site [chemical binding]; other site 1193807002351 active site 1193807002352 pyrophosphate binding site [ion binding]; other site 1193807002353 haloacid dehalogenase superfamily protein; Provisional; Region: PRK14562 1193807002354 Translin family; Region: Translin; cl00957 1193807002355 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 1193807002356 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 1193807002357 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1193807002358 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1193807002359 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1193807002360 dimer interface [polypeptide binding]; other site 1193807002361 motif 1; other site 1193807002362 active site 1193807002363 motif 2; other site 1193807002364 motif 3; other site 1193807002365 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1193807002366 anticodon binding site; other site 1193807002367 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1193807002368 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1193807002369 active site 1193807002370 metal binding site [ion binding]; metal-binding site 1193807002371 DNA binding site [nucleotide binding] 1193807002372 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1193807002373 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1193807002374 RNA binding surface [nucleotide binding]; other site 1193807002375 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1193807002376 active site 1193807002377 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1193807002378 active site 1193807002379 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1193807002380 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1193807002381 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1193807002382 active site 1193807002383 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1193807002384 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1193807002385 active site 1193807002386 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1193807002387 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1193807002388 Walker A/P-loop; other site 1193807002389 ATP binding site [chemical binding]; other site 1193807002390 Q-loop/lid; other site 1193807002391 ABC transporter signature motif; other site 1193807002392 Walker B; other site 1193807002393 D-loop; other site 1193807002394 H-loop/switch region; other site 1193807002395 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1193807002396 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1193807002397 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1193807002398 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1193807002399 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1193807002400 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1193807002401 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 1193807002402 Uncharacterized conserved protein [Function unknown]; Region: COG5495 1193807002403 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1193807002404 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1193807002405 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1193807002406 tetramerization interface [polypeptide binding]; other site 1193807002407 active site 1193807002408 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1193807002409 oligomerization interface [polypeptide binding]; other site 1193807002410 active site 1193807002411 metal binding site [ion binding]; metal-binding site 1193807002412 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1193807002413 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1193807002414 active site 1193807002415 ATP-binding site [chemical binding]; other site 1193807002416 pantoate-binding site; other site 1193807002417 HXXH motif; other site 1193807002418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1193807002419 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1193807002420 putative substrate translocation pore; other site 1193807002421 Predicted transcriptional regulators [Transcription]; Region: COG1695 1193807002422 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1193807002423 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1193807002424 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1193807002425 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1193807002426 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1193807002427 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1193807002428 Walker A/P-loop; other site 1193807002429 ATP binding site [chemical binding]; other site 1193807002430 Q-loop/lid; other site 1193807002431 ABC transporter signature motif; other site 1193807002432 Walker B; other site 1193807002433 D-loop; other site 1193807002434 H-loop/switch region; other site 1193807002435 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1193807002436 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1193807002437 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1193807002438 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1193807002439 Walker A/P-loop; other site 1193807002440 ATP binding site [chemical binding]; other site 1193807002441 Q-loop/lid; other site 1193807002442 ABC transporter signature motif; other site 1193807002443 Walker B; other site 1193807002444 D-loop; other site 1193807002445 H-loop/switch region; other site 1193807002446 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1193807002447 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1193807002448 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1193807002449 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1193807002450 Walker A/P-loop; other site 1193807002451 ATP binding site [chemical binding]; other site 1193807002452 Q-loop/lid; other site 1193807002453 ABC transporter signature motif; other site 1193807002454 Walker B; other site 1193807002455 D-loop; other site 1193807002456 H-loop/switch region; other site 1193807002457 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1193807002458 dimerization interface [polypeptide binding]; other site 1193807002459 active site 1193807002460 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 1193807002461 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1193807002462 hypothetical protein; Reviewed; Region: PRK09588 1193807002463 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1193807002464 putative FMN binding site [chemical binding]; other site 1193807002465 NADPH bind site [chemical binding]; other site 1193807002466 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 1193807002467 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 1193807002468 active site 1193807002469 catalytic residues [active] 1193807002470 metal binding site [ion binding]; metal-binding site 1193807002471 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1193807002472 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1193807002473 tartrate dehydrogenase; Region: TTC; TIGR02089 1193807002474 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 1193807002475 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1193807002476 substrate binding site [chemical binding]; other site 1193807002477 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1193807002478 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1193807002479 substrate binding site [chemical binding]; other site 1193807002480 ligand binding site [chemical binding]; other site 1193807002481 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1193807002482 MgtC family; Region: MgtC; pfam02308 1193807002483 2-isopropylmalate synthase; Validated; Region: PRK00915 1193807002484 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1193807002485 active site 1193807002486 catalytic residues [active] 1193807002487 metal binding site [ion binding]; metal-binding site 1193807002488 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1193807002489 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1193807002490 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1193807002491 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1193807002492 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1193807002493 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1193807002494 putative valine binding site [chemical binding]; other site 1193807002495 dimer interface [polypeptide binding]; other site 1193807002496 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1193807002497 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 1193807002498 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1193807002499 PYR/PP interface [polypeptide binding]; other site 1193807002500 dimer interface [polypeptide binding]; other site 1193807002501 TPP binding site [chemical binding]; other site 1193807002502 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1193807002503 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1193807002504 TPP-binding site [chemical binding]; other site 1193807002505 dimer interface [polypeptide binding]; other site 1193807002506 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1193807002507 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1193807002508 GMP synthase; Reviewed; Region: guaA; PRK00074 1193807002509 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1193807002510 AMP/PPi binding site [chemical binding]; other site 1193807002511 candidate oxyanion hole; other site 1193807002512 catalytic triad [active] 1193807002513 potential glutamine specificity residues [chemical binding]; other site 1193807002514 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1193807002515 ATP Binding subdomain [chemical binding]; other site 1193807002516 Ligand Binding sites [chemical binding]; other site 1193807002517 Dimerization subdomain; other site 1193807002518 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 1193807002519 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1193807002520 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1193807002521 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1193807002522 AIR carboxylase; Region: AIRC; pfam00731 1193807002523 adenylosuccinate lyase; Provisional; Region: PRK07492 1193807002524 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1193807002525 tetramer interface [polypeptide binding]; other site 1193807002526 active site 1193807002527 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1193807002528 active site 1193807002529 ATP binding site [chemical binding]; other site 1193807002530 substrate binding site [chemical binding]; other site 1193807002531 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1193807002532 putative active site pocket [active] 1193807002533 4-fold oligomerization interface [polypeptide binding]; other site 1193807002534 metal binding residues [ion binding]; metal-binding site 1193807002535 3-fold/trimer interface [polypeptide binding]; other site 1193807002536 histidinol-phosphate aminotransferase; Provisional; Region: PLN03026 1193807002537 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1193807002538 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1193807002539 homodimer interface [polypeptide binding]; other site 1193807002540 catalytic residue [active] 1193807002541 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1193807002542 histidinol dehydrogenase; Region: hisD; TIGR00069 1193807002543 NAD binding site [chemical binding]; other site 1193807002544 dimerization interface [polypeptide binding]; other site 1193807002545 product binding site; other site 1193807002546 substrate binding site [chemical binding]; other site 1193807002547 zinc binding site [ion binding]; other site 1193807002548 catalytic residues [active] 1193807002549 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1193807002550 ATP phosphoribosyltransferase; Region: HisG; cl15266 1193807002551 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 1193807002552 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1193807002553 dimer interface [polypeptide binding]; other site 1193807002554 motif 1; other site 1193807002555 active site 1193807002556 motif 2; other site 1193807002557 motif 3; other site 1193807002558 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 1193807002559 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1193807002560 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1193807002561 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1193807002562 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1193807002563 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1193807002564 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 1193807002565 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1193807002566 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 1193807002567 Walker A/P-loop; other site 1193807002568 ATP binding site [chemical binding]; other site 1193807002569 Q-loop/lid; other site 1193807002570 ABC transporter signature motif; other site 1193807002571 Walker B; other site 1193807002572 D-loop; other site 1193807002573 H-loop/switch region; other site 1193807002574 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1193807002575 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1193807002576 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1193807002577 threonine dehydratase; Reviewed; Region: PRK09224 1193807002578 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1193807002579 FtsX-like permease family; Region: FtsX; pfam02687 1193807002580 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1193807002581 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1193807002582 Walker A/P-loop; other site 1193807002583 ATP binding site [chemical binding]; other site 1193807002584 Q-loop/lid; other site 1193807002585 ABC transporter signature motif; other site 1193807002586 Walker B; other site 1193807002587 D-loop; other site 1193807002588 H-loop/switch region; other site 1193807002589 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 1193807002590 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1193807002591 FeS/SAM binding site; other site 1193807002592 HemN C-terminal domain; Region: HemN_C; pfam06969 1193807002593 GTP-binding protein LepA; Provisional; Region: PRK05433 1193807002594 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1193807002595 G1 box; other site 1193807002596 putative GEF interaction site [polypeptide binding]; other site 1193807002597 GTP/Mg2+ binding site [chemical binding]; other site 1193807002598 Switch I region; other site 1193807002599 G2 box; other site 1193807002600 G3 box; other site 1193807002601 Switch II region; other site 1193807002602 G4 box; other site 1193807002603 G5 box; other site 1193807002604 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1193807002605 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1193807002606 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1193807002607 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651 1193807002608 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1193807002609 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1193807002610 NADH dehydrogenase; Region: NADHdh; cl00469 1193807002611 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1193807002612 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 1193807002613 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1193807002614 putative dimer interface [polypeptide binding]; other site 1193807002615 [2Fe-2S] cluster binding site [ion binding]; other site 1193807002616 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1193807002617 dimer interface [polypeptide binding]; other site 1193807002618 [2Fe-2S] cluster binding site [ion binding]; other site 1193807002619 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1193807002620 SLBB domain; Region: SLBB; pfam10531 1193807002621 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1193807002622 4Fe-4S binding domain; Region: Fer4; pfam00037 1193807002623 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1193807002624 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1193807002625 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1193807002626 catalytic loop [active] 1193807002627 iron binding site [ion binding]; other site 1193807002628 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1193807002629 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1193807002630 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1193807002631 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1193807002632 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1193807002633 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1193807002634 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1193807002635 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1193807002636 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 1193807002637 motif 1; other site 1193807002638 dimer interface [polypeptide binding]; other site 1193807002639 active site 1193807002640 motif 2; other site 1193807002641 motif 3; other site 1193807002642 elongation factor P; Validated; Region: PRK00529 1193807002643 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1193807002644 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1193807002645 RNA binding site [nucleotide binding]; other site 1193807002646 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1193807002647 RNA binding site [nucleotide binding]; other site 1193807002648 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1193807002649 MarR family; Region: MarR; pfam01047 1193807002650 Transport protein; Region: actII; TIGR00833 1193807002651 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1193807002652 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1193807002653 non-specific DNA binding site [nucleotide binding]; other site 1193807002654 salt bridge; other site 1193807002655 sequence-specific DNA binding site [nucleotide binding]; other site 1193807002656 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 1193807002657 Catalytic site [active] 1193807002658 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1193807002659 putative Zn2+ binding site [ion binding]; other site 1193807002660 putative DNA binding site [nucleotide binding]; other site 1193807002661 arsenical pump membrane protein; Provisional; Region: PRK15445 1193807002662 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1193807002663 transmembrane helices; other site 1193807002664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1193807002665 putative substrate translocation pore; other site 1193807002666 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1193807002667 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1193807002668 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1193807002669 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1193807002670 active site 1193807002671 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 1193807002672 diiron binding motif [ion binding]; other site 1193807002673 PAC2 family; Region: PAC2; pfam09754 1193807002674 PAC2 family; Region: PAC2; pfam09754 1193807002675 ATP-dependent DNA ligase; Provisional; Region: PRK01109 1193807002676 hypothetical protein; Provisional; Region: PRK04334 1193807002677 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1193807002678 4Fe-4S binding domain; Region: Fer4; cl02805 1193807002679 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1193807002680 Domain of unknown function DUF39; Region: DUF39; pfam01837 1193807002681 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1193807002682 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1193807002683 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1193807002684 Walker A motif; other site 1193807002685 Walker A/P-loop; other site 1193807002686 ATP binding site [chemical binding]; other site 1193807002687 ATP binding site [chemical binding]; other site 1193807002688 Walker B motif; other site 1193807002689 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 1193807002690 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1193807002691 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 1193807002692 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1193807002693 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1193807002694 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1193807002695 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1193807002696 4Fe-4S binding domain; Region: Fer4; pfam00037 1193807002697 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1193807002698 4Fe-4S binding domain; Region: Fer4; pfam00037 1193807002699 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1193807002700 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1193807002701 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1193807002702 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1193807002703 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1193807002704 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1193807002705 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1193807002706 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1193807002707 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1193807002708 NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00144 1193807002709 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1193807002710 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1193807002711 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1193807002712 active site 1193807002713 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1193807002714 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1193807002715 minor groove reading motif; other site 1193807002716 helix-hairpin-helix signature motif; other site 1193807002717 substrate binding pocket [chemical binding]; other site 1193807002718 active site 1193807002719 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1193807002720 cobyric acid synthase; Provisional; Region: PRK00784 1193807002721 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1193807002722 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1193807002723 catalytic triad [active] 1193807002724 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1193807002725 CoenzymeA binding site [chemical binding]; other site 1193807002726 subunit interaction site [polypeptide binding]; other site 1193807002727 PHB binding site; other site 1193807002728 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1193807002729 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1193807002730 Walker A/P-loop; other site 1193807002731 ATP binding site [chemical binding]; other site 1193807002732 Q-loop/lid; other site 1193807002733 ABC transporter signature motif; other site 1193807002734 Walker B; other site 1193807002735 D-loop; other site 1193807002736 H-loop/switch region; other site 1193807002737 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1193807002738 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1193807002739 acyl-activating enzyme (AAE) consensus motif; other site 1193807002740 active site 1193807002741 AMP binding site [chemical binding]; other site 1193807002742 CoA binding site [chemical binding]; other site 1193807002743 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1193807002744 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1193807002745 Walker A/P-loop; other site 1193807002746 ATP binding site [chemical binding]; other site 1193807002747 Q-loop/lid; other site 1193807002748 ABC transporter signature motif; other site 1193807002749 Walker B; other site 1193807002750 D-loop; other site 1193807002751 H-loop/switch region; other site 1193807002752 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1193807002753 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1193807002754 ligand binding site [chemical binding]; other site 1193807002755 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1193807002756 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1193807002757 ligand binding site [chemical binding]; other site 1193807002758 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1193807002759 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1193807002760 TM-ABC transporter signature motif; other site 1193807002761 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1193807002762 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1193807002763 TM-ABC transporter signature motif; other site 1193807002764 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1193807002765 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1193807002766 putative AMP binding site [chemical binding]; other site 1193807002767 putative active site [active] 1193807002768 putative CoA binding site [chemical binding]; other site 1193807002769 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 1193807002770 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1193807002771 dimer interface [polypeptide binding]; other site 1193807002772 PYR/PP interface [polypeptide binding]; other site 1193807002773 TPP binding site [chemical binding]; other site 1193807002774 substrate binding site [chemical binding]; other site 1193807002775 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 1193807002776 TPP-binding site; other site 1193807002777 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 1193807002778 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1193807002779 DNA polymerase II large subunit; Validated; Region: PRK04023 1193807002780 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1193807002781 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1193807002782 trimerization site [polypeptide binding]; other site 1193807002783 active site 1193807002784 Predicted membrane protein [Function unknown]; Region: COG3462 1193807002785 Short C-terminal domain; Region: SHOCT; pfam09851 1193807002786 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1193807002787 metal-binding site [ion binding] 1193807002788 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1193807002789 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1193807002790 metal-binding site [ion binding] 1193807002791 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1193807002792 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1193807002793 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1193807002794 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1193807002795 putative dimer interface [polypeptide binding]; other site 1193807002796 Ferritin-like domain; Region: Ferritin; pfam00210 1193807002797 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1193807002798 dinuclear metal binding motif [ion binding]; other site 1193807002799 Ferritin-like domain; Region: Ferritin; pfam00210 1193807002800 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1193807002801 dinuclear metal binding motif [ion binding]; other site 1193807002802 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1193807002803 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1193807002804 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1193807002805 The Death Domain Superfamily of protein-protein interaction domains; Region: DD_superfamily; cl14633 1193807002806 Smr domain; Region: Smr; pfam01713 1193807002807 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1193807002808 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1193807002809 substrate binding site [chemical binding]; other site 1193807002810 glutamase interaction surface [polypeptide binding]; other site 1193807002811 Repressor of nif and glnA expression [Transcription]; Region: COG1693 1193807002812 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 1193807002813 Domain of unknown function DUF128; Region: DUF128; pfam01995 1193807002814 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1193807002815 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 1193807002816 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1193807002817 FeS/SAM binding site; other site 1193807002818 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1193807002819 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1193807002820 dimer interface [polypeptide binding]; other site 1193807002821 active site 1193807002822 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1193807002823 DHH family; Region: DHH; pfam01368 1193807002824 DHHA1 domain; Region: DHHA1; pfam02272 1193807002825 membrane protein; Provisional; Region: PRK14414 1193807002826 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1193807002827 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1193807002828 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1193807002829 ATP binding site [chemical binding]; other site 1193807002830 putative Mg++ binding site [ion binding]; other site 1193807002831 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1193807002832 nucleotide binding region [chemical binding]; other site 1193807002833 ATP-binding site [chemical binding]; other site 1193807002834 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1193807002835 Protein of unknown function (DUF503); Region: DUF503; pfam04456 1193807002836 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1193807002837 16S/18S rRNA binding site [nucleotide binding]; other site 1193807002838 S13e-L30e interaction site [polypeptide binding]; other site 1193807002839 25S rRNA binding site [nucleotide binding]; other site 1193807002840 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1193807002841 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1193807002842 RNase E interface [polypeptide binding]; other site 1193807002843 trimer interface [polypeptide binding]; other site 1193807002844 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1193807002845 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1193807002846 RNase E interface [polypeptide binding]; other site 1193807002847 trimer interface [polypeptide binding]; other site 1193807002848 active site 1193807002849 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1193807002850 putative nucleic acid binding region [nucleotide binding]; other site 1193807002851 G-X-X-G motif; other site 1193807002852 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1193807002853 RNA binding site [nucleotide binding]; other site 1193807002854 domain interface; other site 1193807002855 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1193807002856 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1193807002857 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1193807002858 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1193807002859 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1193807002860 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1193807002861 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1193807002862 dimer interface [polypeptide binding]; other site 1193807002863 active site 1193807002864 catalytic residue [active] 1193807002865 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1193807002866 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1193807002867 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1193807002868 Coenzyme A binding pocket [chemical binding]; other site 1193807002869 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1193807002870 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1193807002871 GDP-binding site [chemical binding]; other site 1193807002872 ACT binding site; other site 1193807002873 IMP binding site; other site 1193807002874 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1193807002875 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1193807002876 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1193807002877 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1193807002878 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1193807002879 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 1193807002880 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1193807002881 RNA binding site [nucleotide binding]; other site 1193807002882 active site 1193807002883 Ribosome-binding factor A; Region: RBFA; pfam02033 1193807002884 translation initiation factor IF-2; Region: IF-2; TIGR00487 1193807002885 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1193807002886 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1193807002887 G1 box; other site 1193807002888 putative GEF interaction site [polypeptide binding]; other site 1193807002889 GTP/Mg2+ binding site [chemical binding]; other site 1193807002890 Switch I region; other site 1193807002891 G2 box; other site 1193807002892 G3 box; other site 1193807002893 Switch II region; other site 1193807002894 G4 box; other site 1193807002895 G5 box; other site 1193807002896 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1193807002897 Translation-initiation factor 2; Region: IF-2; pfam11987 1193807002898 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1193807002899 Protein of unknown function (DUF448); Region: DUF448; pfam04296 1193807002900 putative RNA binding cleft [nucleotide binding]; other site 1193807002901 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1193807002902 NusA N-terminal domain; Region: NusA_N; pfam08529 1193807002903 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1193807002904 RNA binding site [nucleotide binding]; other site 1193807002905 homodimer interface [polypeptide binding]; other site 1193807002906 NusA-like KH domain; Region: KH_5; pfam13184 1193807002907 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1193807002908 G-X-X-G motif; other site 1193807002909 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1193807002910 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1193807002911 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1193807002912 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1193807002913 Walker A motif; other site 1193807002914 ATP binding site [chemical binding]; other site 1193807002915 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1193807002916 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1193807002917 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1193807002918 Coenzyme A binding pocket [chemical binding]; other site 1193807002919 Uncharacterized conserved protein [Function unknown]; Region: COG2928 1193807002920 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1193807002921 core dimer interface [polypeptide binding]; other site 1193807002922 peripheral dimer interface [polypeptide binding]; other site 1193807002923 L10 interface [polypeptide binding]; other site 1193807002924 L11 interface [polypeptide binding]; other site 1193807002925 putative EF-Tu interaction site [polypeptide binding]; other site 1193807002926 putative EF-G interaction site [polypeptide binding]; other site 1193807002927 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1193807002928 23S rRNA interface [nucleotide binding]; other site 1193807002929 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1193807002930 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1193807002931 mRNA/rRNA interface [nucleotide binding]; other site 1193807002932 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1193807002933 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1193807002934 23S rRNA interface [nucleotide binding]; other site 1193807002935 L7/L12 interface [polypeptide binding]; other site 1193807002936 putative thiostrepton binding site; other site 1193807002937 L25 interface [polypeptide binding]; other site 1193807002938 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1193807002939 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1193807002940 putative homodimer interface [polypeptide binding]; other site 1193807002941 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1193807002942 heterodimer interface [polypeptide binding]; other site 1193807002943 homodimer interface [polypeptide binding]; other site 1193807002944 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1193807002945 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1193807002946 elongation factor Tu; Reviewed; Region: PRK12735 1193807002947 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1193807002948 G1 box; other site 1193807002949 GEF interaction site [polypeptide binding]; other site 1193807002950 GTP/Mg2+ binding site [chemical binding]; other site 1193807002951 Switch I region; other site 1193807002952 G2 box; other site 1193807002953 G3 box; other site 1193807002954 Switch II region; other site 1193807002955 G4 box; other site 1193807002956 G5 box; other site 1193807002957 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1193807002958 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1193807002959 Antibiotic Binding Site [chemical binding]; other site 1193807002960 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1193807002961 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1193807002962 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1193807002963 putative ADP-binding pocket [chemical binding]; other site 1193807002964 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1193807002965 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1193807002966 dimerization interface [polypeptide binding]; other site 1193807002967 putative DNA binding site [nucleotide binding]; other site 1193807002968 putative Zn2+ binding site [ion binding]; other site 1193807002969 Predicted permease; Region: DUF318; cl17795 1193807002970 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 1193807002971 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1193807002972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1193807002973 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1193807002974 putative substrate translocation pore; other site 1193807002975 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1193807002976 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1193807002977 HPP family; Region: HPP; pfam04982 1193807002978 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 1193807002979 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1193807002980 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1193807002981 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1193807002982 acyl-activating enzyme (AAE) consensus motif; other site 1193807002983 AMP binding site [chemical binding]; other site 1193807002984 active site 1193807002985 CoA binding site [chemical binding]; other site 1193807002986 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1193807002987 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1193807002988 putative active site [active] 1193807002989 heme pocket [chemical binding]; other site 1193807002990 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1193807002991 putative active site [active] 1193807002992 heme pocket [chemical binding]; other site 1193807002993 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1193807002994 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1193807002995 putative active site [active] 1193807002996 heme pocket [chemical binding]; other site 1193807002997 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1193807002998 putative active site [active] 1193807002999 heme pocket [chemical binding]; other site 1193807003000 PAS domain S-box; Region: sensory_box; TIGR00229 1193807003001 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1193807003002 putative active site [active] 1193807003003 heme pocket [chemical binding]; other site 1193807003004 PAS domain S-box; Region: sensory_box; TIGR00229 1193807003005 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1193807003006 putative active site [active] 1193807003007 heme pocket [chemical binding]; other site 1193807003008 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1193807003009 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1193807003010 putative active site [active] 1193807003011 heme pocket [chemical binding]; other site 1193807003012 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1193807003013 dimer interface [polypeptide binding]; other site 1193807003014 phosphorylation site [posttranslational modification] 1193807003015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1193807003016 ATP binding site [chemical binding]; other site 1193807003017 Mg2+ binding site [ion binding]; other site 1193807003018 G-X-G motif; other site 1193807003019 Response regulator receiver domain; Region: Response_reg; pfam00072 1193807003020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1193807003021 active site 1193807003022 phosphorylation site [posttranslational modification] 1193807003023 intermolecular recognition site; other site 1193807003024 dimerization interface [polypeptide binding]; other site 1193807003025 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 1193807003026 ribonuclease III; Reviewed; Region: rnc; PRK00102 1193807003027 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1193807003028 dimerization interface [polypeptide binding]; other site 1193807003029 active site 1193807003030 metal binding site [ion binding]; metal-binding site 1193807003031 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1193807003032 dsRNA binding site [nucleotide binding]; other site 1193807003033 acylphosphatase; Provisional; Region: PRK14450 1193807003034 Domain of unknown function (DUF362); Region: DUF362; pfam04015 1193807003035 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1193807003036 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1193807003037 interface (dimer of trimers) [polypeptide binding]; other site 1193807003038 Substrate-binding/catalytic site; other site 1193807003039 Zn-binding sites [ion binding]; other site 1193807003040 AAA domain; Region: AAA_33; pfam13671 1193807003041 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1193807003042 active site 1193807003043 EDD domain protein, DegV family; Region: DegV; TIGR00762 1193807003044 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1193807003045 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1193807003046 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1193807003047 acyl-activating enzyme (AAE) consensus motif; other site 1193807003048 active site 1193807003049 AMP binding site [chemical binding]; other site 1193807003050 CoA binding site [chemical binding]; other site 1193807003051 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1193807003052 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1193807003053 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1193807003054 catalytic residue [active] 1193807003055 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1193807003056 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1193807003057 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1193807003058 protein binding site [polypeptide binding]; other site 1193807003059 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1193807003060 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1193807003061 HIGH motif; other site 1193807003062 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1193807003063 active site 1193807003064 KMSKS motif; other site 1193807003065 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1193807003066 tRNA binding surface [nucleotide binding]; other site 1193807003067 anticodon binding site; other site 1193807003068 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1193807003069 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1193807003070 G-X-X-G motif; other site 1193807003071 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1193807003072 RxxxH motif; other site 1193807003073 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1193807003074 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1193807003075 PQQ-like domain; Region: PQQ_2; pfam13360 1193807003076 Trp docking motif [polypeptide binding]; other site 1193807003077 PQQ-like domain; Region: PQQ_2; pfam13360 1193807003078 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1193807003079 Trp docking motif [polypeptide binding]; other site 1193807003080 active site 1193807003081 Haemolytic domain; Region: Haemolytic; pfam01809 1193807003082 Ribonuclease P; Region: Ribonuclease_P; pfam00825 1193807003083 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1193807003084 30S ribosomal protein S18; Provisional; Region: PRK13400 1193807003085 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1193807003086 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1193807003087 dimer interface [polypeptide binding]; other site 1193807003088 ssDNA binding site [nucleotide binding]; other site 1193807003089 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1193807003090 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 1193807003091 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1193807003092 homotrimer interaction site [polypeptide binding]; other site 1193807003093 putative active site [active] 1193807003094 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1193807003095 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 1193807003096 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 1193807003097 nucleotide binding site [chemical binding]; other site 1193807003098 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1193807003099 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1193807003100 Walker A/P-loop; other site 1193807003101 ATP binding site [chemical binding]; other site 1193807003102 Q-loop/lid; other site 1193807003103 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1193807003104 Q-loop/lid; other site 1193807003105 ABC transporter signature motif; other site 1193807003106 Walker B; other site 1193807003107 D-loop; other site 1193807003108 H-loop/switch region; other site 1193807003109 EamA-like transporter family; Region: EamA; pfam00892 1193807003110 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1193807003111 EamA-like transporter family; Region: EamA; pfam00892 1193807003112 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1193807003113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1193807003114 active site 1193807003115 phosphorylation site [posttranslational modification] 1193807003116 intermolecular recognition site; other site 1193807003117 dimerization interface [polypeptide binding]; other site 1193807003118 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1193807003119 DNA binding site [nucleotide binding] 1193807003120 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1193807003121 dimerization interface [polypeptide binding]; other site 1193807003122 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1193807003123 dimer interface [polypeptide binding]; other site 1193807003124 phosphorylation site [posttranslational modification] 1193807003125 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1193807003126 ATP binding site [chemical binding]; other site 1193807003127 Mg2+ binding site [ion binding]; other site 1193807003128 G-X-G motif; other site 1193807003129 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1193807003130 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1193807003131 Walker A/P-loop; other site 1193807003132 ATP binding site [chemical binding]; other site 1193807003133 Q-loop/lid; other site 1193807003134 ABC transporter signature motif; other site 1193807003135 Walker B; other site 1193807003136 D-loop; other site 1193807003137 H-loop/switch region; other site 1193807003138 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1193807003139 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1193807003140 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1193807003141 Walker A/P-loop; other site 1193807003142 ATP binding site [chemical binding]; other site 1193807003143 Q-loop/lid; other site 1193807003144 ABC transporter signature motif; other site 1193807003145 Walker B; other site 1193807003146 D-loop; other site 1193807003147 H-loop/switch region; other site 1193807003148 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1193807003149 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1193807003150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1193807003151 dimer interface [polypeptide binding]; other site 1193807003152 conserved gate region; other site 1193807003153 putative PBP binding loops; other site 1193807003154 ABC-ATPase subunit interface; other site 1193807003155 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1193807003156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1193807003157 dimer interface [polypeptide binding]; other site 1193807003158 conserved gate region; other site 1193807003159 putative PBP binding loops; other site 1193807003160 ABC-ATPase subunit interface; other site 1193807003161 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1193807003162 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1193807003163 peptide binding site [polypeptide binding]; other site 1193807003164 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1193807003165 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1193807003166 Beta-Casp domain; Region: Beta-Casp; smart01027 1193807003167 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1193807003168 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1193807003169 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1193807003170 active site 1193807003171 phosphorylation site [posttranslational modification] 1193807003172 intermolecular recognition site; other site 1193807003173 dimerization interface [polypeptide binding]; other site 1193807003174 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1193807003175 DNA binding residues [nucleotide binding] 1193807003176 dimerization interface [polypeptide binding]; other site 1193807003177 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1193807003178 PAS domain; Region: PAS_9; pfam13426 1193807003179 putative active site [active] 1193807003180 heme pocket [chemical binding]; other site 1193807003181 PAS fold; Region: PAS_4; pfam08448 1193807003182 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1193807003183 putative active site [active] 1193807003184 heme pocket [chemical binding]; other site 1193807003185 GAF domain; Region: GAF_3; pfam13492 1193807003186 GAF domain; Region: GAF_2; pfam13185 1193807003187 PAS domain S-box; Region: sensory_box; TIGR00229 1193807003188 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1193807003189 putative active site [active] 1193807003190 heme pocket [chemical binding]; other site 1193807003191 PAS domain; Region: PAS; smart00091 1193807003192 PAS domain; Region: PAS_9; pfam13426 1193807003193 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1193807003194 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1193807003195 putative active site [active] 1193807003196 heme pocket [chemical binding]; other site 1193807003197 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1193807003198 putative active site [active] 1193807003199 heme pocket [chemical binding]; other site 1193807003200 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1193807003201 Histidine kinase; Region: HisKA_3; pfam07730 1193807003202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1193807003203 ATP binding site [chemical binding]; other site 1193807003204 Mg2+ binding site [ion binding]; other site 1193807003205 G-X-G motif; other site 1193807003206 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1193807003207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1193807003208 S-adenosylmethionine binding site [chemical binding]; other site 1193807003209 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1193807003210 active site clefts [active] 1193807003211 zinc binding site [ion binding]; other site 1193807003212 Maf-like protein; Region: Maf; pfam02545 1193807003213 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1193807003214 active site 1193807003215 dimer interface [polypeptide binding]; other site 1193807003216 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 1193807003217 NAD synthetase; Provisional; Region: PRK13981 1193807003218 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1193807003219 multimer interface [polypeptide binding]; other site 1193807003220 active site 1193807003221 catalytic triad [active] 1193807003222 protein interface 1 [polypeptide binding]; other site 1193807003223 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1193807003224 homodimer interface [polypeptide binding]; other site 1193807003225 NAD binding pocket [chemical binding]; other site 1193807003226 ATP binding pocket [chemical binding]; other site 1193807003227 Mg binding site [ion binding]; other site 1193807003228 active-site loop [active] 1193807003229 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1193807003230 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1193807003231 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1193807003232 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1193807003233 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1193807003234 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1193807003235 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1193807003236 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1193807003237 DNA binding site [nucleotide binding] 1193807003238 Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981 1193807003239 putative subunit interface; other site 1193807003240 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1193807003241 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1193807003242 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1193807003243 active site 1193807003244 FMN binding site [chemical binding]; other site 1193807003245 substrate binding site [chemical binding]; other site 1193807003246 3Fe-4S cluster binding site [ion binding]; other site 1193807003247 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1193807003248 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1193807003249 substrate binding site [chemical binding]; other site 1193807003250 glutamase interaction surface [polypeptide binding]; other site 1193807003251 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 1193807003252 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1193807003253 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1193807003254 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 1193807003255 putative active site [active] 1193807003256 active site 1193807003257 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1193807003258 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1193807003259 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1193807003260 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1193807003261 putative active site [active] 1193807003262 oxyanion strand; other site 1193807003263 catalytic triad [active] 1193807003264 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 1193807003265 Predicted membrane protein [Function unknown]; Region: COG1971 1193807003266 Domain of unknown function DUF; Region: DUF204; pfam02659 1193807003267 Domain of unknown function DUF; Region: DUF204; pfam02659 1193807003268 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1193807003269 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1193807003270 dimer interface [polypeptide binding]; other site 1193807003271 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1193807003272 catalytic residue [active] 1193807003273 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1193807003274 FeS/SAM binding site; other site 1193807003275 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1193807003276 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 1193807003277 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1193807003278 Walker A motif; other site 1193807003279 homodimer interface [polypeptide binding]; other site 1193807003280 ATP binding site [chemical binding]; other site 1193807003281 hydroxycobalamin binding site [chemical binding]; other site 1193807003282 Walker B motif; other site 1193807003283 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1193807003284 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1193807003285 active site 1193807003286 catalytic triad [active] 1193807003287 dimer interface [polypeptide binding]; other site 1193807003288 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 1193807003289 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1193807003290 DXD motif; other site 1193807003291 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1193807003292 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1193807003293 NodB motif; other site 1193807003294 active site 1193807003295 catalytic site [active] 1193807003296 metal binding site [ion binding]; metal-binding site 1193807003297 Baculoviral E56 protein, specific to ODV envelope; Region: Baculo_E56; pfam04639 1193807003298 Protease prsW family; Region: PrsW-protease; pfam13367 1193807003299 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1193807003300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1193807003301 active site 1193807003302 phosphorylation site [posttranslational modification] 1193807003303 intermolecular recognition site; other site 1193807003304 dimerization interface [polypeptide binding]; other site 1193807003305 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1193807003306 DNA binding residues [nucleotide binding] 1193807003307 dimerization interface [polypeptide binding]; other site 1193807003308 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1193807003309 CoA binding domain; Region: CoA_binding_2; pfam13380 1193807003310 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1193807003311 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1193807003312 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1193807003313 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1193807003314 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1193807003315 metal binding site 2 [ion binding]; metal-binding site 1193807003316 putative DNA binding helix; other site 1193807003317 metal binding site 1 [ion binding]; metal-binding site 1193807003318 dimer interface [polypeptide binding]; other site 1193807003319 structural Zn2+ binding site [ion binding]; other site 1193807003320 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1193807003321 Predicted transcriptional regulators [Transcription]; Region: COG1695 1193807003322 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1193807003323 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1193807003324 MarR family; Region: MarR; pfam01047 1193807003325 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1193807003326 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1193807003327 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1193807003328 Walker A/P-loop; other site 1193807003329 ATP binding site [chemical binding]; other site 1193807003330 Q-loop/lid; other site 1193807003331 ABC transporter signature motif; other site 1193807003332 Walker B; other site 1193807003333 D-loop; other site 1193807003334 H-loop/switch region; other site 1193807003335 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1193807003336 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1193807003337 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1193807003338 Walker A/P-loop; other site 1193807003339 ATP binding site [chemical binding]; other site 1193807003340 Q-loop/lid; other site 1193807003341 ABC transporter signature motif; other site 1193807003342 Walker B; other site 1193807003343 D-loop; other site 1193807003344 H-loop/switch region; other site 1193807003345 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1193807003346 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1193807003347 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1193807003348 MarR family; Region: MarR_2; pfam12802 1193807003349 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 1193807003350 reductive dehalogenase; Region: RDH; TIGR02486 1193807003351 4Fe-4S binding domain; Region: Fer4; pfam00037 1193807003352 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 1193807003353 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1193807003354 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 1193807003355 BioY family; Region: BioY; pfam02632 1193807003356 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cd01342 1193807003357 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1193807003358 homopentamer interface [polypeptide binding]; other site 1193807003359 active site 1193807003360 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1193807003361 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1193807003362 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1193807003363 dimerization interface [polypeptide binding]; other site 1193807003364 active site 1193807003365 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1193807003366 Lumazine binding domain; Region: Lum_binding; pfam00677 1193807003367 Lumazine binding domain; Region: Lum_binding; pfam00677 1193807003368 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1193807003369 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1193807003370 catalytic motif [active] 1193807003371 Zn binding site [ion binding]; other site 1193807003372 RibD C-terminal domain; Region: RibD_C; cl17279 1193807003373 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1193807003374 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1193807003375 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1193807003376 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1193807003377 Catalytic site [active] 1193807003378 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1193807003379 active site 1193807003380 Endonuclease related to archaeal Holliday junction resolvase; Region: Endonuc_Holl; pfam10107 1193807003381 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1193807003382 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1193807003383 ATP binding site [chemical binding]; other site 1193807003384 Mg2+ binding site [ion binding]; other site 1193807003385 G-X-G motif; other site 1193807003386 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1193807003387 ATP binding site [chemical binding]; other site 1193807003388 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1193807003389 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1193807003390 Part of AAA domain; Region: AAA_19; pfam13245 1193807003391 AAA domain; Region: AAA_12; pfam13087 1193807003392 Family description; Region: UvrD_C_2; pfam13538 1193807003393 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1193807003394 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1193807003395 active site 1193807003396 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1193807003397 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1193807003398 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1193807003399 dihydroorotase; Validated; Region: pyrC; PRK09357 1193807003400 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1193807003401 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1193807003402 active site 1193807003403 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1193807003404 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1193807003405 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1193807003406 catalytic site [active] 1193807003407 subunit interface [polypeptide binding]; other site 1193807003408 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1193807003409 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1193807003410 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1193807003411 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1193807003412 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1193807003413 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1193807003414 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1193807003415 IMP binding site; other site 1193807003416 dimer interface [polypeptide binding]; other site 1193807003417 interdomain contacts; other site 1193807003418 partial ornithine binding site; other site 1193807003419 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1193807003420 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1193807003421 FAD binding pocket [chemical binding]; other site 1193807003422 FAD binding motif [chemical binding]; other site 1193807003423 phosphate binding motif [ion binding]; other site 1193807003424 beta-alpha-beta structure motif; other site 1193807003425 NAD binding pocket [chemical binding]; other site 1193807003426 Iron coordination center [ion binding]; other site 1193807003427 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1193807003428 homodecamer interface [polypeptide binding]; other site 1193807003429 GTP cyclohydrolase I; Provisional; Region: PLN03044 1193807003430 active site 1193807003431 putative catalytic site residues [active] 1193807003432 zinc binding site [ion binding]; other site 1193807003433 GTP-CH-I/GFRP interaction surface; other site 1193807003434 threonine synthase; Reviewed; Region: PRK06721 1193807003435 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1193807003436 homodimer interface [polypeptide binding]; other site 1193807003437 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1193807003438 catalytic residue [active] 1193807003439 homoserine dehydrogenase; Provisional; Region: PRK06349 1193807003440 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1193807003441 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1193807003442 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1193807003443 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1193807003444 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1193807003445 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1193807003446 active site 1193807003447 Substrate binding site; other site 1193807003448 Mg++ binding site; other site 1193807003449 putative trimer interface [polypeptide binding]; other site 1193807003450 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 1193807003451 putative CoA binding site [chemical binding]; other site 1193807003452 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 1193807003453 acetyl-CoA synthetase; Provisional; Region: PRK00174 1193807003454 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1193807003455 active site 1193807003456 CoA binding site [chemical binding]; other site 1193807003457 acyl-activating enzyme (AAE) consensus motif; other site 1193807003458 AMP binding site [chemical binding]; other site 1193807003459 acetate binding site [chemical binding]; other site 1193807003460 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1193807003461 PCRF domain; Region: PCRF; pfam03462 1193807003462 RF-1 domain; Region: RF-1; pfam00472 1193807003463 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1193807003464 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1193807003465 S-adenosylmethionine binding site [chemical binding]; other site 1193807003466 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1193807003467 elongation factor G; Reviewed; Region: PRK12740 1193807003468 G1 box; other site 1193807003469 putative GEF interaction site [polypeptide binding]; other site 1193807003470 GTP/Mg2+ binding site [chemical binding]; other site 1193807003471 Switch I region; other site 1193807003472 G2 box; other site 1193807003473 G3 box; other site 1193807003474 Switch II region; other site 1193807003475 G4 box; other site 1193807003476 G5 box; other site 1193807003477 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1193807003478 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1193807003479 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1193807003480 Integral membrane protein DUF95; Region: DUF95; pfam01944 1193807003481 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1193807003482 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1193807003483 active site 1193807003484 Int/Topo IB signature motif; other site 1193807003485 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1193807003486 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1193807003487 GIY-YIG motif/motif A; other site 1193807003488 active site 1193807003489 catalytic site [active] 1193807003490 putative DNA binding site [nucleotide binding]; other site 1193807003491 metal binding site [ion binding]; metal-binding site 1193807003492 UvrB/uvrC motif; Region: UVR; pfam02151 1193807003493 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1193807003494 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1193807003495 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1193807003496 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1193807003497 active site 1193807003498 motif I; other site 1193807003499 motif II; other site 1193807003500 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1193807003501 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1193807003502 MutS domain I; Region: MutS_I; pfam01624 1193807003503 MutS domain II; Region: MutS_II; pfam05188 1193807003504 MutS domain III; Region: MutS_III; pfam05192 1193807003505 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1193807003506 Walker A/P-loop; other site 1193807003507 ATP binding site [chemical binding]; other site 1193807003508 Q-loop/lid; other site 1193807003509 ABC transporter signature motif; other site 1193807003510 Walker B; other site 1193807003511 D-loop; other site 1193807003512 H-loop/switch region; other site 1193807003513 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1193807003514 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1193807003515 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1193807003516 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1193807003517 homodimer interface [polypeptide binding]; other site 1193807003518 Walker A motif; other site 1193807003519 ATP binding site [chemical binding]; other site 1193807003520 hydroxycobalamin binding site [chemical binding]; other site 1193807003521 Walker B motif; other site 1193807003522 Fructose-1,6-bisphosphatase; Region: FBPase_3; pfam01950 1193807003523 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1193807003524 active site 1193807003525 dimerization interface [polypeptide binding]; other site 1193807003526 DNA polymerase III subunit beta; Validated; Region: PRK05643 1193807003527 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1193807003528 putative DNA binding surface [nucleotide binding]; other site 1193807003529 dimer interface [polypeptide binding]; other site 1193807003530 beta-clamp/clamp loader binding surface; other site 1193807003531 beta-clamp/translesion DNA polymerase binding surface; other site 1193807003532 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1193807003533 Domain of unknown function (DU1801); Region: DUF1801; cl17490 1193807003534 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1193807003535 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1193807003536 Smr domain; Region: Smr; pfam01713 1193807003537 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1193807003538 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1193807003539 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1193807003540 putative active site [active] 1193807003541 putative substrate binding site [chemical binding]; other site 1193807003542 putative cosubstrate binding site; other site 1193807003543 catalytic site [active] 1193807003544 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1193807003545 active site 1193807003546 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1193807003547 arsenical-resistance protein; Region: acr3; TIGR00832 1193807003548 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1193807003549 methionine sulfoxide reductase B; Provisional; Region: PRK05508 1193807003550 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 1193807003551 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1193807003552 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1193807003553 TfoX N-terminal domain; Region: TfoX_N; pfam04993 1193807003554 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1193807003555 dimerization interface [polypeptide binding]; other site 1193807003556 putative DNA binding site [nucleotide binding]; other site 1193807003557 putative Zn2+ binding site [ion binding]; other site 1193807003558 Predicted integral membrane protein [Function unknown]; Region: COG5658 1193807003559 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1193807003560 SdpI/YhfL protein family; Region: SdpI; pfam13630 1193807003561 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1193807003562 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1193807003563 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1193807003564 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1193807003565 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1193807003566 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1193807003567 Walker A motif; other site 1193807003568 Walker A/P-loop; other site 1193807003569 ATP binding site [chemical binding]; other site 1193807003570 ATP binding site [chemical binding]; other site 1193807003571 Walker B motif; other site 1193807003572 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1193807003573 heterotetramer interface [polypeptide binding]; other site 1193807003574 active site pocket [active] 1193807003575 cleavage site 1193807003576 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1193807003577 nucleotide binding site [chemical binding]; other site 1193807003578 N-acetyl-L-glutamate binding site [chemical binding]; other site 1193807003579 acetylornithine aminotransferase; Provisional; Region: PRK02627 1193807003580 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1193807003581 inhibitor-cofactor binding pocket; inhibition site 1193807003582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1193807003583 catalytic residue [active] 1193807003584 argininosuccinate synthase; Provisional; Region: PRK13820 1193807003585 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1193807003586 ANP binding site [chemical binding]; other site 1193807003587 Substrate Binding Site II [chemical binding]; other site 1193807003588 Substrate Binding Site I [chemical binding]; other site 1193807003589 argininosuccinate lyase; Provisional; Region: PRK00855 1193807003590 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1193807003591 active sites [active] 1193807003592 tetramer interface [polypeptide binding]; other site 1193807003593 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1193807003594 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1193807003595 DAK2 domain; Region: Dak2; pfam02734 1193807003596 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1193807003597 EDD domain protein, DegV family; Region: DegV; TIGR00762 1193807003598 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1193807003599 EDD domain protein, DegV family; Region: DegV; TIGR00762 1193807003600 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1193807003601 EDD domain protein, DegV family; Region: DegV; TIGR00762 1193807003602 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1193807003603 EDD domain protein, DegV family; Region: DegV; TIGR00762 1193807003604 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1193807003605 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1193807003606 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1193807003607 generic binding surface II; other site 1193807003608 ssDNA binding site; other site 1193807003609 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1193807003610 ATP binding site [chemical binding]; other site 1193807003611 putative Mg++ binding site [ion binding]; other site 1193807003612 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1193807003613 nucleotide binding region [chemical binding]; other site 1193807003614 ATP-binding site [chemical binding]; other site 1193807003615 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 1193807003616 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1193807003617 Zn2+ binding site [ion binding]; other site 1193807003618 Mg2+ binding site [ion binding]; other site 1193807003619 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1193807003620 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1193807003621 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1193807003622 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1193807003623 active site 1193807003624 HIGH motif; other site 1193807003625 KMSK motif region; other site 1193807003626 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1193807003627 tRNA binding surface [nucleotide binding]; other site 1193807003628 anticodon binding site; other site 1193807003629 AsnC family; Region: AsnC_trans_reg; pfam01037 1193807003630 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1193807003631 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 1193807003632 NAD binding site [chemical binding]; other site 1193807003633 homotetramer interface [polypeptide binding]; other site 1193807003634 homodimer interface [polypeptide binding]; other site 1193807003635 substrate binding site [chemical binding]; other site 1193807003636 active site 1193807003637 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1193807003638 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1193807003639 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1193807003640 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1193807003641 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1193807003642 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1193807003643 NAD(P) binding site [chemical binding]; other site 1193807003644 homotetramer interface [polypeptide binding]; other site 1193807003645 homodimer interface [polypeptide binding]; other site 1193807003646 active site 1193807003647 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1193807003648 putative RNA binding site [nucleotide binding]; other site 1193807003649 acyl carrier protein; Provisional; Region: acpP; PRK00982 1193807003650 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1193807003651 B12 binding site [chemical binding]; other site 1193807003652 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1193807003653 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1193807003654 FeS/SAM binding site; other site 1193807003655 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 1193807003656 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1193807003657 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1193807003658 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1193807003659 ATP binding site [chemical binding]; other site 1193807003660 putative Mg++ binding site [ion binding]; other site 1193807003661 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1193807003662 nucleotide binding region [chemical binding]; other site 1193807003663 ATP-binding site [chemical binding]; other site 1193807003664 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1193807003665 gamma-glutamyl kinase; Provisional; Region: PRK05429 1193807003666 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1193807003667 nucleotide binding site [chemical binding]; other site 1193807003668 homotetrameric interface [polypeptide binding]; other site 1193807003669 putative phosphate binding site [ion binding]; other site 1193807003670 putative allosteric binding site; other site 1193807003671 PUA domain; Region: PUA; pfam01472 1193807003672 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1193807003673 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1193807003674 protein binding site [polypeptide binding]; other site 1193807003675 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1193807003676 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1193807003677 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1193807003678 DNA binding residues [nucleotide binding] 1193807003679 dimer interface [polypeptide binding]; other site 1193807003680 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1193807003681 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1193807003682 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1193807003683 putative catalytic cysteine [active] 1193807003684 ribonuclease PH; Reviewed; Region: rph; PRK00173 1193807003685 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1193807003686 hexamer interface [polypeptide binding]; other site 1193807003687 active site 1193807003688 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1193807003689 nudix motif; other site 1193807003690 Competence-damaged protein; Region: CinA; pfam02464 1193807003691 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 1193807003692 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1193807003693 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1193807003694 dimer interface [polypeptide binding]; other site 1193807003695 phosphorylation site [posttranslational modification] 1193807003696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1193807003697 ATP binding site [chemical binding]; other site 1193807003698 Mg2+ binding site [ion binding]; other site 1193807003699 G-X-G motif; other site 1193807003700 Helix-turn-helix domain; Region: HTH_17; pfam12728 1193807003701 Response regulator receiver domain; Region: Response_reg; pfam00072 1193807003702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1193807003703 active site 1193807003704 phosphorylation site [posttranslational modification] 1193807003705 intermolecular recognition site; other site 1193807003706 dimerization interface [polypeptide binding]; other site 1193807003707 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1193807003708 Probable zinc-binding domain; Region: zf-trcl; pfam13451 1193807003709 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 1193807003710 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1193807003711 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1193807003712 G1 box; other site 1193807003713 putative GEF interaction site [polypeptide binding]; other site 1193807003714 GTP/Mg2+ binding site [chemical binding]; other site 1193807003715 Switch I region; other site 1193807003716 G2 box; other site 1193807003717 G3 box; other site 1193807003718 Switch II region; other site 1193807003719 G4 box; other site 1193807003720 G5 box; other site 1193807003721 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1193807003722 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1193807003723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1193807003724 metabolite-proton symporter; Region: 2A0106; TIGR00883 1193807003725 putative substrate translocation pore; other site 1193807003726 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1193807003727 Ligand Binding Site [chemical binding]; other site 1193807003728 Uncharacterized conserved protein [Function unknown]; Region: COG2928 1193807003729 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1193807003730 Fasciclin domain; Region: Fasciclin; pfam02469 1193807003731 Glycosyl transferase 4-like; Region: Glyco_trans_4_2; pfam13477 1193807003732 Uncharacterized conserved protein [Function unknown]; Region: COG3422 1193807003733 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1193807003734 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1193807003735 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1193807003736 recombination factor protein RarA; Reviewed; Region: PRK13342 1193807003737 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1193807003738 Walker A motif; other site 1193807003739 ATP binding site [chemical binding]; other site 1193807003740 Walker B motif; other site 1193807003741 arginine finger; other site 1193807003742 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1193807003743 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 1193807003744 putative ligand binding pocket/active site [active] 1193807003745 putative metal binding site [ion binding]; other site 1193807003746 AMMECR1; Region: AMMECR1; pfam01871 1193807003747 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 1193807003748 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 1193807003749 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1193807003750 FeS/SAM binding site; other site 1193807003751 EamA-like transporter family; Region: EamA; pfam00892 1193807003752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1193807003753 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1193807003754 YcxB-like protein; Region: YcxB; pfam14317 1193807003755 Predicted ATPase [General function prediction only]; Region: COG3910 1193807003756 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1193807003757 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1193807003758 Walker A/P-loop; other site 1193807003759 Walker A/P-loop; other site 1193807003760 ATP binding site [chemical binding]; other site 1193807003761 ATP binding site [chemical binding]; other site 1193807003762 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1193807003763 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1193807003764 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1193807003765 Coenzyme A binding pocket [chemical binding]; other site 1193807003766 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1193807003767 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1193807003768 CoA-binding site [chemical binding]; other site 1193807003769 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1193807003770 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 1193807003771 putative NAD(P) binding site [chemical binding]; other site 1193807003772 active site 1193807003773 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1193807003774 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1193807003775 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1193807003776 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1193807003777 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 1193807003778 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1193807003779 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1193807003780 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1193807003781 Coenzyme A binding pocket [chemical binding]; other site 1193807003782 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1193807003783 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1193807003784 catalytic residues [active] 1193807003785 Protein of unknown function (DUF2769); Region: DUF2769; pfam10967 1193807003786 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 1193807003787 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1193807003788 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1193807003789 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1193807003790 Predicted membrane protein (DUF2178); Region: DUF2178; pfam09946 1193807003791 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1193807003792 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1193807003793 non-specific DNA binding site [nucleotide binding]; other site 1193807003794 salt bridge; other site 1193807003795 sequence-specific DNA binding site [nucleotide binding]; other site 1193807003796 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1193807003797 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1193807003798 Walker A/P-loop; other site 1193807003799 ATP binding site [chemical binding]; other site 1193807003800 Q-loop/lid; other site 1193807003801 ABC transporter signature motif; other site 1193807003802 Walker B; other site 1193807003803 D-loop; other site 1193807003804 H-loop/switch region; other site 1193807003805 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1193807003806 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1193807003807 AsnC family; Region: AsnC_trans_reg; pfam01037 1193807003808 hypothetical protein; Validated; Region: PRK07682 1193807003809 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1193807003810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1193807003811 homodimer interface [polypeptide binding]; other site 1193807003812 catalytic residue [active] 1193807003813 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1193807003814 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1193807003815 active site 1193807003816 HIGH motif; other site 1193807003817 dimer interface [polypeptide binding]; other site 1193807003818 KMSKS motif; other site 1193807003819 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1193807003820 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 1193807003821 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12858 1193807003822 catalytic residue [active] 1193807003823 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1193807003824 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1193807003825 putative substrate binding site [chemical binding]; other site 1193807003826 putative ATP binding site [chemical binding]; other site 1193807003827 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 1193807003828 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1193807003829 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1193807003830 DNA binding residues [nucleotide binding] 1193807003831 Helix-turn-helix domain; Region: HTH_17; pfam12728 1193807003832 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1193807003833 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1193807003834 active site 1193807003835 phosphorylation site [posttranslational modification] 1193807003836 intermolecular recognition site; other site 1193807003837 dimerization interface [polypeptide binding]; other site 1193807003838 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1193807003839 DNA binding residues [nucleotide binding] 1193807003840 dimerization interface [polypeptide binding]; other site 1193807003841 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1193807003842 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1193807003843 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1193807003844 Walker A motif; other site 1193807003845 ATP binding site [chemical binding]; other site 1193807003846 Walker B motif; other site 1193807003847 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1193807003848 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1193807003849 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1193807003850 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1193807003851 PilX N-terminal; Region: PilX_N; pfam14341 1193807003852 Competence protein A; Region: Competence_A; pfam11104 1193807003853 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1193807003854 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1193807003855 Walker A motif; other site 1193807003856 ATP binding site [chemical binding]; other site 1193807003857 Walker B motif; other site 1193807003858 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1193807003859 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1193807003860 bifunctional mannosyl-3-phosphoglycerate synthase/mannosyl-3 phosphoglycerate phosphatase; Provisional; Region: PRK14502 1193807003861 mannosyl-3-phosphoglycerate synthase; Provisional; Region: PRK14503; cl12225 1193807003862 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1193807003863 active site 1193807003864 motif I; other site 1193807003865 motif II; other site 1193807003866 RDD family; Region: RDD; pfam06271 1193807003867 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1193807003868 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1193807003869 HIGH motif; other site 1193807003870 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1193807003871 active site 1193807003872 KMSKS motif; other site 1193807003873 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 1193807003874 Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins [General function prediction only]; Region: PflX; COG1313 1193807003875 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1193807003876 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 1193807003877 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1193807003878 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1193807003879 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1193807003880 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1193807003881 heterodimer interface [polypeptide binding]; other site 1193807003882 active site 1193807003883 FMN binding site [chemical binding]; other site 1193807003884 homodimer interface [polypeptide binding]; other site 1193807003885 substrate binding site [chemical binding]; other site 1193807003886 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1193807003887 lipoprotein signal peptidase; Provisional; Region: PRK14784 1193807003888 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1193807003889 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1193807003890 RNA binding surface [nucleotide binding]; other site 1193807003891 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1193807003892 active site 1193807003893 Predicted transcriptional regulator [Transcription]; Region: COG3432 1193807003894 Phospholipid methyltransferase; Region: PEMT; cl17370 1193807003895 GH3 auxin-responsive promoter; Region: GH3; pfam03321 1193807003896 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1193807003897 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1193807003898 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1193807003899 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1193807003900 metal binding site [ion binding]; metal-binding site 1193807003901 active site 1193807003902 I-site; other site 1193807003903 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1193807003904 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1193807003905 Zn2+ binding site [ion binding]; other site 1193807003906 Mg2+ binding site [ion binding]; other site 1193807003907 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 1193807003908 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1193807003909 dimerization interface [polypeptide binding]; other site 1193807003910 active site 1193807003911 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 1193807003912 L-aspartate oxidase; Provisional; Region: PRK06175 1193807003913 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1193807003914 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1193807003915 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14336 1193807003916 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1193807003917 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1193807003918 FeS/SAM binding site; other site 1193807003919 TRAM domain; Region: TRAM; pfam01938 1193807003920 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1193807003921 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 1193807003922 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 1193807003923 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1193807003924 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1193807003925 DNA binding site [nucleotide binding] 1193807003926 catalytic residue [active] 1193807003927 H2TH interface [polypeptide binding]; other site 1193807003928 putative catalytic residues [active] 1193807003929 turnover-facilitating residue; other site 1193807003930 intercalation triad [nucleotide binding]; other site 1193807003931 8OG recognition residue [nucleotide binding]; other site 1193807003932 putative reading head residues; other site 1193807003933 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1193807003934 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1193807003935 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1193807003936 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1193807003937 active site 1193807003938 DNA polymerase I; Provisional; Region: PRK05755 1193807003939 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1193807003940 active site 1193807003941 metal binding site 1 [ion binding]; metal-binding site 1193807003942 putative 5' ssDNA interaction site; other site 1193807003943 metal binding site 3; metal-binding site 1193807003944 metal binding site 2 [ion binding]; metal-binding site 1193807003945 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1193807003946 putative DNA binding site [nucleotide binding]; other site 1193807003947 putative metal binding site [ion binding]; other site 1193807003948 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1193807003949 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1193807003950 active site 1193807003951 DNA binding site [nucleotide binding] 1193807003952 catalytic site [active] 1193807003953 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1193807003954 active site residue [active] 1193807003955 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1193807003956 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1193807003957 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1193807003958 GTP-binding protein Der; Reviewed; Region: PRK00093 1193807003959 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1193807003960 G1 box; other site 1193807003961 GTP/Mg2+ binding site [chemical binding]; other site 1193807003962 Switch I region; other site 1193807003963 G2 box; other site 1193807003964 Switch II region; other site 1193807003965 G3 box; other site 1193807003966 G4 box; other site 1193807003967 G5 box; other site 1193807003968 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1193807003969 G1 box; other site 1193807003970 GTP/Mg2+ binding site [chemical binding]; other site 1193807003971 Switch I region; other site 1193807003972 G2 box; other site 1193807003973 G3 box; other site 1193807003974 Switch II region; other site 1193807003975 G4 box; other site 1193807003976 G5 box; other site 1193807003977 membrane protein; Provisional; Region: PRK14415 1193807003978 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1193807003979 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1193807003980 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1193807003981 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 1193807003982 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1193807003983 HSP70 interaction site [polypeptide binding]; other site 1193807003984 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1193807003985 substrate binding site [polypeptide binding]; other site 1193807003986 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1193807003987 Zn binding sites [ion binding]; other site 1193807003988 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1193807003989 dimer interface [polypeptide binding]; other site 1193807003990 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1193807003991 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1193807003992 nucleotide binding site [chemical binding]; other site 1193807003993 NEF interaction site [polypeptide binding]; other site 1193807003994 SBD interface [polypeptide binding]; other site 1193807003995 GrpE; Region: GrpE; pfam01025 1193807003996 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1193807003997 dimer interface [polypeptide binding]; other site 1193807003998 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1193807003999 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 1193807004000 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1193807004001 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 1193807004002 Caspase domain; Region: Peptidase_C14; pfam00656 1193807004003 RNase_H superfamily; Region: RNase_H_2; pfam13482 1193807004004 active site 1193807004005 catalytic site [active] 1193807004006 substrate binding site [chemical binding]; other site 1193807004007 active site 1193807004008 substrate binding site [chemical binding]; other site 1193807004009 catalytic site [active] 1193807004010 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1193807004011 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1193807004012 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1193807004013 RNA binding site [nucleotide binding]; other site 1193807004014 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1193807004015 Walker A motif; other site 1193807004016 ATP binding site [chemical binding]; other site 1193807004017 Walker B motif; other site 1193807004018 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1193807004019 active site 1193807004020 intersubunit interactions; other site 1193807004021 catalytic residue [active] 1193807004022 CTP synthetase; Validated; Region: pyrG; PRK05380 1193807004023 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1193807004024 active site 1193807004025 UTP binding site [chemical binding]; other site 1193807004026 Catalytic site [active] 1193807004027 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1193807004028 active site 1193807004029 putative oxyanion hole; other site 1193807004030 catalytic triad [active] 1193807004031 chaperone protein DnaJ; Provisional; Region: PRK10767 1193807004032 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1193807004033 HSP70 interaction site [polypeptide binding]; other site 1193807004034 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1193807004035 substrate binding site [polypeptide binding]; other site 1193807004036 dimer interface [polypeptide binding]; other site 1193807004037 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1193807004038 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1193807004039 DNA binding residues [nucleotide binding] 1193807004040 putative dimer interface [polypeptide binding]; other site 1193807004041 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1193807004042 Clp amino terminal domain; Region: Clp_N; pfam02861 1193807004043 Clp amino terminal domain; Region: Clp_N; pfam02861 1193807004044 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1193807004045 Walker A motif; other site 1193807004046 ATP binding site [chemical binding]; other site 1193807004047 Walker B motif; other site 1193807004048 arginine finger; other site 1193807004049 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1193807004050 Walker A motif; other site 1193807004051 ATP binding site [chemical binding]; other site 1193807004052 Walker B motif; other site 1193807004053 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1193807004054 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1193807004055 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 1193807004056 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1193807004057 active site 1193807004058 tetramer interface [polypeptide binding]; other site 1193807004059 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1193807004060 active site 1193807004061 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1193807004062 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1193807004063 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1193807004064 dimerization interface [polypeptide binding]; other site 1193807004065 putative ATP binding site [chemical binding]; other site 1193807004066 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1193807004067 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1193807004068 S-adenosylmethionine binding site [chemical binding]; other site 1193807004069 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1193807004070 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1193807004071 purine monophosphate binding site [chemical binding]; other site 1193807004072 dimer interface [polypeptide binding]; other site 1193807004073 putative catalytic residues [active] 1193807004074 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1193807004075 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1193807004076 nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662 1193807004077 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 1193807004078 active site 1193807004079 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1193807004080 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1193807004081 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1193807004082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1193807004083 S-adenosylmethionine binding site [chemical binding]; other site 1193807004084 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1193807004085 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1193807004086 Ligand Binding Site [chemical binding]; other site 1193807004087 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1193807004088 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1193807004089 catalytic core [active] 1193807004090 Peptidase family M48; Region: Peptidase_M48; cl12018 1193807004091 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 1193807004092 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 1193807004093 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1193807004094 Domain of unknown function DUF21; Region: DUF21; pfam01595 1193807004095 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1193807004096 Transporter associated domain; Region: CorC_HlyC; smart01091 1193807004097 UGMP family protein; Validated; Region: PRK09604 1193807004098 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1193807004099 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1193807004100 oligomerisation interface [polypeptide binding]; other site 1193807004101 mobile loop; other site 1193807004102 roof hairpin; other site 1193807004103 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1193807004104 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1193807004105 ring oligomerisation interface [polypeptide binding]; other site 1193807004106 ATP/Mg binding site [chemical binding]; other site 1193807004107 stacking interactions; other site 1193807004108 hinge regions; other site 1193807004109 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1193807004110 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1193807004111 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1193807004112 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1193807004113 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 1193807004114 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1193807004115 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1193807004116 Acylphosphatase; Region: Acylphosphatase; pfam00708 1193807004117 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1193807004118 HypF finger; Region: zf-HYPF; pfam07503 1193807004119 HypF finger; Region: zf-HYPF; pfam07503 1193807004120 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1193807004121 HupF/HypC family; Region: HupF_HypC; pfam01455 1193807004122 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1193807004123 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1193807004124 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1193807004125 dimerization interface [polypeptide binding]; other site 1193807004126 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1193807004127 ATP binding site [chemical binding]; other site 1193807004128 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1193807004129 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1193807004130 glyceraldehyde-3-phosphate dehydrogenase B; Region: PLN02237 1193807004131 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1193807004132 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1193807004133 DNA binding residues [nucleotide binding] 1193807004134 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 1193807004135 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824 1193807004136 putative hydrophobic ligand binding site [chemical binding]; other site 1193807004137 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1193807004138 putative active site pocket [active] 1193807004139 dimerization interface [polypeptide binding]; other site 1193807004140 putative catalytic residue [active] 1193807004141 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1193807004142 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1193807004143 5S rRNA interface [nucleotide binding]; other site 1193807004144 CTC domain interface [polypeptide binding]; other site 1193807004145 L16 interface [polypeptide binding]; other site 1193807004146 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1193807004147 Amidohydrolase; Region: Amidohydro_2; pfam04909 1193807004148 active site 1193807004149 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1193807004150 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1193807004151 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1193807004152 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1193807004153 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1193807004154 active site 1193807004155 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1193807004156 30S subunit binding site; other site 1193807004157 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1193807004158 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1193807004159 DNA binding site [nucleotide binding] 1193807004160 active site 1193807004161 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 1193807004162 hypothetical protein; Reviewed; Region: PRK00024 1193807004163 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1193807004164 helix-hairpin-helix signature motif; other site 1193807004165 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1193807004166 MPN+ (JAMM) motif; other site 1193807004167 Zinc-binding site [ion binding]; other site 1193807004168 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 1193807004169 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 1193807004170 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1193807004171 active site 1193807004172 PHP Thumb interface [polypeptide binding]; other site 1193807004173 metal binding site [ion binding]; metal-binding site 1193807004174 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1193807004175 generic binding surface II; other site 1193807004176 generic binding surface I; other site 1193807004177 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 1193807004178 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 1193807004179 anthranilate synthase component I; Provisional; Region: PRK13565 1193807004180 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1193807004181 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1193807004182 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1193807004183 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1193807004184 glutamine binding [chemical binding]; other site 1193807004185 catalytic triad [active] 1193807004186 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1193807004187 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1193807004188 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1193807004189 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1193807004190 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1193807004191 active site 1193807004192 ribulose/triose binding site [chemical binding]; other site 1193807004193 phosphate binding site [ion binding]; other site 1193807004194 substrate (anthranilate) binding pocket [chemical binding]; other site 1193807004195 product (indole) binding pocket [chemical binding]; other site 1193807004196 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1193807004197 active site 1193807004198 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 1193807004199 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1193807004200 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1193807004201 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1193807004202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1193807004203 catalytic residue [active] 1193807004204 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1193807004205 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1193807004206 substrate binding site [chemical binding]; other site 1193807004207 active site 1193807004208 catalytic residues [active] 1193807004209 heterodimer interface [polypeptide binding]; other site 1193807004210 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 1193807004211 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 1193807004212 reductive dehalogenase; Region: RDH; TIGR02486 1193807004213 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 1193807004214 reductive dehalogenase; Region: RDH; TIGR02486 1193807004215 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1193807004216 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1193807004217 Thymidylate synthase complementing protein; Region: Thy1; pfam02511 1193807004218 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1193807004219 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1193807004220 Walker A/P-loop; other site 1193807004221 ATP binding site [chemical binding]; other site 1193807004222 Q-loop/lid; other site 1193807004223 ABC transporter signature motif; other site 1193807004224 Walker B; other site 1193807004225 D-loop; other site 1193807004226 H-loop/switch region; other site 1193807004227 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1193807004228 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1193807004229 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1193807004230 Walker A/P-loop; other site 1193807004231 ATP binding site [chemical binding]; other site 1193807004232 Q-loop/lid; other site 1193807004233 ABC transporter signature motif; other site 1193807004234 Walker B; other site 1193807004235 D-loop; other site 1193807004236 H-loop/switch region; other site 1193807004237 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1193807004238 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1193807004239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1193807004240 dimer interface [polypeptide binding]; other site 1193807004241 conserved gate region; other site 1193807004242 putative PBP binding loops; other site 1193807004243 ABC-ATPase subunit interface; other site 1193807004244 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1193807004245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1193807004246 dimer interface [polypeptide binding]; other site 1193807004247 conserved gate region; other site 1193807004248 putative PBP binding loops; other site 1193807004249 ABC-ATPase subunit interface; other site 1193807004250 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1193807004251 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1193807004252 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1193807004253 S-adenosylmethionine binding site [chemical binding]; other site 1193807004254 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1193807004255 MarR family; Region: MarR_2; pfam12802 1193807004256 camphor resistance protein CrcB; Provisional; Region: PRK14212 1193807004257 Predicted transcriptional regulator [Transcription]; Region: COG1497 1193807004258 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1193807004259 non-specific DNA interactions [nucleotide binding]; other site 1193807004260 DNA binding site [nucleotide binding] 1193807004261 sequence specific DNA binding site [nucleotide binding]; other site 1193807004262 putative cAMP binding site [chemical binding]; other site 1193807004263 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1193807004264 Flavodoxins [Energy production and conversion]; Region: FldA; COG0716 1193807004265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1193807004266 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1193807004267 putative substrate translocation pore; other site 1193807004268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1193807004269 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1193807004270 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1193807004271 G1 box; other site 1193807004272 GTP/Mg2+ binding site [chemical binding]; other site 1193807004273 Switch I region; other site 1193807004274 G2 box; other site 1193807004275 G3 box; other site 1193807004276 Switch II region; other site 1193807004277 G4 box; other site 1193807004278 G5 box; other site 1193807004279 Nucleoside recognition; Region: Gate; pfam07670 1193807004280 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1193807004281 Nucleoside recognition; Region: Gate; pfam07670 1193807004282 FeoA domain; Region: FeoA; pfam04023 1193807004283 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1193807004284 metal binding site 2 [ion binding]; metal-binding site 1193807004285 putative DNA binding helix; other site 1193807004286 metal binding site 1 [ion binding]; metal-binding site 1193807004287 dimer interface [polypeptide binding]; other site 1193807004288 structural Zn2+ binding site [ion binding]; other site 1193807004289 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1193807004290 SmpB-tmRNA interface; other site 1193807004291 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 1193807004292 reductive dehalogenase; Region: RDH; TIGR02486 1193807004293 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1193807004294 putative DNA binding site [nucleotide binding]; other site 1193807004295 dimerization interface [polypeptide binding]; other site 1193807004296 putative Zn2+ binding site [ion binding]; other site 1193807004297 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 1193807004298 reductive dehalogenase; Region: RDH; TIGR02486 1193807004299 4Fe-4S binding domain; Region: Fer4; pfam00037 1193807004300 PAS domain S-box; Region: sensory_box; TIGR00229 1193807004301 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1193807004302 putative active site [active] 1193807004303 heme pocket [chemical binding]; other site 1193807004304 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1193807004305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1193807004306 ATP binding site [chemical binding]; other site 1193807004307 Mg2+ binding site [ion binding]; other site 1193807004308 G-X-G motif; other site 1193807004309 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1193807004310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1193807004311 active site 1193807004312 phosphorylation site [posttranslational modification] 1193807004313 intermolecular recognition site; other site 1193807004314 dimerization interface [polypeptide binding]; other site 1193807004315 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1193807004316 DNA binding site [nucleotide binding] 1193807004317 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 1193807004318 reductive dehalogenase; Region: RDH; TIGR02486 1193807004319 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1193807004320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1193807004321 active site 1193807004322 phosphorylation site [posttranslational modification] 1193807004323 intermolecular recognition site; other site 1193807004324 dimerization interface [polypeptide binding]; other site 1193807004325 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1193807004326 DNA binding site [nucleotide binding] 1193807004327 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1193807004328 PAS domain; Region: PAS_9; pfam13426 1193807004329 putative active site [active] 1193807004330 heme pocket [chemical binding]; other site 1193807004331 PAS domain S-box; Region: sensory_box; TIGR00229 1193807004332 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1193807004333 putative active site [active] 1193807004334 heme pocket [chemical binding]; other site 1193807004335 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1193807004336 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1193807004337 dimer interface [polypeptide binding]; other site 1193807004338 phosphorylation site [posttranslational modification] 1193807004339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1193807004340 ATP binding site [chemical binding]; other site 1193807004341 Mg2+ binding site [ion binding]; other site 1193807004342 G-X-G motif; other site 1193807004343 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 1193807004344 Flagellin N-methylase; Region: FliB; cl00497 1193807004345 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 1193807004346 reductive dehalogenase; Region: RDH; TIGR02486 1193807004347 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1193807004348 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1193807004349 putative active site [active] 1193807004350 heme pocket [chemical binding]; other site 1193807004351 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1193807004352 dimer interface [polypeptide binding]; other site 1193807004353 phosphorylation site [posttranslational modification] 1193807004354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1193807004355 ATP binding site [chemical binding]; other site 1193807004356 Mg2+ binding site [ion binding]; other site 1193807004357 G-X-G motif; other site 1193807004358 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1193807004359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1193807004360 active site 1193807004361 phosphorylation site [posttranslational modification] 1193807004362 intermolecular recognition site; other site 1193807004363 dimerization interface [polypeptide binding]; other site 1193807004364 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1193807004365 DNA binding site [nucleotide binding] 1193807004366 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1193807004367 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1193807004368 FeS/SAM binding site; other site 1193807004369 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1193807004370 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 1193807004371 reductive dehalogenase; Region: RDH; TIGR02486 1193807004372 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 1193807004373 reductive dehalogenase; Region: RDH; TIGR02486 1193807004374 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1193807004375 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1193807004376 active site 1193807004377 phosphorylation site [posttranslational modification] 1193807004378 intermolecular recognition site; other site 1193807004379 dimerization interface [polypeptide binding]; other site 1193807004380 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1193807004381 DNA binding site [nucleotide binding] 1193807004382 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 1193807004383 PAS domain; Region: PAS_9; pfam13426 1193807004384 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1193807004385 putative active site [active] 1193807004386 heme pocket [chemical binding]; other site 1193807004387 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1193807004388 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1193807004389 dimer interface [polypeptide binding]; other site 1193807004390 phosphorylation site [posttranslational modification] 1193807004391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1193807004392 ATP binding site [chemical binding]; other site 1193807004393 Mg2+ binding site [ion binding]; other site 1193807004394 G-X-G motif; other site 1193807004395 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1193807004396 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1193807004397 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1193807004398 DNA binding residues [nucleotide binding] 1193807004399 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1193807004400 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1193807004401 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1193807004402 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1193807004403 ParB-like nuclease domain; Region: ParB; smart00470 1193807004404 DDE superfamily endonuclease; Region: DDE_5; cl17874 1193807004405 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1193807004406 generic binding surface II; other site 1193807004407 generic binding surface I; other site 1193807004408 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cl08187 1193807004409 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 1193807004410 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 1193807004411 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1193807004412 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 1193807004413 CT1975-like protein; Region: Cas_CT1975; pfam09344 1193807004414 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 1193807004415 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 1193807004416 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1193807004417 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 1193807004418 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1193807004419 Double zinc ribbon; Region: DZR; pfam12773 1193807004420 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1193807004421 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 1193807004422 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG4342 1193807004423 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1193807004424 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 1193807004425 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1193807004426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1193807004427 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1193807004428 Walker A motif; other site 1193807004429 ATP binding site [chemical binding]; other site 1193807004430 Walker B motif; other site 1193807004431 arginine finger; other site 1193807004432 Predicted transcriptional regulator [Transcription]; Region: COG2378 1193807004433 HTH domain; Region: HTH_11; pfam08279 1193807004434 WYL domain; Region: WYL; pfam13280 1193807004435 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1193807004436 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1193807004437 ATP binding site [chemical binding]; other site 1193807004438 putative Mg++ binding site [ion binding]; other site 1193807004439 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 1193807004440 PAS domain; Region: PAS_9; pfam13426 1193807004441 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1193807004442 putative active site [active] 1193807004443 heme pocket [chemical binding]; other site 1193807004444 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1193807004445 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1193807004446 dimer interface [polypeptide binding]; other site 1193807004447 phosphorylation site [posttranslational modification] 1193807004448 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1193807004449 ATP binding site [chemical binding]; other site 1193807004450 Mg2+ binding site [ion binding]; other site 1193807004451 G-X-G motif; other site 1193807004452 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1193807004453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1193807004454 active site 1193807004455 phosphorylation site [posttranslational modification] 1193807004456 intermolecular recognition site; other site 1193807004457 dimerization interface [polypeptide binding]; other site 1193807004458 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1193807004459 DNA binding site [nucleotide binding] 1193807004460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1193807004461 G-X-G motif; other site 1193807004462 reductive dehalogenase; Region: RDH; TIGR02486 1193807004463 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 1193807004464 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 1193807004465 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1193807004466 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 1193807004467 DNA binding residues [nucleotide binding] 1193807004468 putative dimer interface [polypeptide binding]; other site 1193807004469 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 1193807004470 reductive dehalogenase; Region: RDH; TIGR02486 1193807004471 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 1193807004472 reductive dehalogenase; Region: RDH; TIGR02486 1193807004473 4Fe-4S binding domain; Region: Fer4; pfam00037 1193807004474 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 1193807004475 reductive dehalogenase; Region: RDH; TIGR02486 1193807004476 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1193807004477 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1193807004478 putative active site [active] 1193807004479 heme pocket [chemical binding]; other site 1193807004480 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1193807004481 dimer interface [polypeptide binding]; other site 1193807004482 phosphorylation site [posttranslational modification] 1193807004483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1193807004484 ATP binding site [chemical binding]; other site 1193807004485 Mg2+ binding site [ion binding]; other site 1193807004486 G-X-G motif; other site 1193807004487 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1193807004488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1193807004489 active site 1193807004490 phosphorylation site [posttranslational modification] 1193807004491 intermolecular recognition site; other site 1193807004492 dimerization interface [polypeptide binding]; other site 1193807004493 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1193807004494 DNA binding site [nucleotide binding] 1193807004495 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1193807004496 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 1193807004497 reductive dehalogenase; Region: RDH; TIGR02486 1193807004498 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1193807004499 Prephenate dehydratase; Region: PDT; pfam00800 1193807004500 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1193807004501 putative L-Phe binding site [chemical binding]; other site 1193807004502 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 1193807004503 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1193807004504 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1193807004505 GatB domain; Region: GatB_Yqey; smart00845 1193807004506 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1193807004507 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1193807004508 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1193807004509 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1193807004510 DNA binding residues [nucleotide binding] 1193807004511 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 1193807004512 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1193807004513 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1193807004514 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1193807004515 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1193807004516 hydrogenase membrane subunit; Validated; Region: PRK08676 1193807004517 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1193807004518 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 1193807004519 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1193807004520 NADH dehydrogenase; Region: NADHdh; cl00469 1193807004521 hydrogenase membrane subunit; Validated; Region: PRK08667 1193807004522 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1193807004523 methylglyoxal synthase; Validated; Region: mgsA; PRK05234 1193807004524 substrate binding site [chemical binding]; other site 1193807004525 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 1193807004526 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1193807004527 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1193807004528 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1193807004529 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1193807004530 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1193807004531 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 1193807004532 putative NADP binding site [chemical binding]; other site 1193807004533 putative substrate binding site [chemical binding]; other site 1193807004534 active site 1193807004535 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1193807004536 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1193807004537 NAD(P) binding site [chemical binding]; other site 1193807004538 active site 1193807004539 peroxiredoxin; Provisional; Region: PRK13189 1193807004540 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 1193807004541 dimer interface [polypeptide binding]; other site 1193807004542 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1193807004543 catalytic triad [active] 1193807004544 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 1193807004545 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 1193807004546 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1193807004547 Peptidase family M48; Region: Peptidase_M48; cl12018 1193807004548 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1193807004549 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1193807004550 trimer interface [polypeptide binding]; other site 1193807004551 active site 1193807004552 substrate binding site [chemical binding]; other site 1193807004553 CoA binding site [chemical binding]; other site 1193807004554 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 1193807004555 Quinolinate synthetase A protein; Region: NadA; pfam02445 1193807004556 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1193807004557 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1193807004558 S-adenosylmethionine binding site [chemical binding]; other site 1193807004559 AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061 1193807004560 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309 1193807004561 dimerization interface [polypeptide binding]; other site 1193807004562 putative ATP binding site [chemical binding]; other site 1193807004563 Predicted transcriptional regulator [Transcription]; Region: COG1959 1193807004564 Transcriptional regulator; Region: Rrf2; cl17282 1193807004565 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1193807004566 ApbE family; Region: ApbE; pfam02424 1193807004567 FMN-binding domain; Region: FMN_bind; pfam04205 1193807004568 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1193807004569 FMN-binding domain; Region: FMN_bind; pfam04205 1193807004570 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 1193807004571 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1193807004572 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1193807004573 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 1193807004574 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1193807004575 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1193807004576 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1193807004577 dihydropteroate synthase; Region: DHPS; TIGR01496 1193807004578 substrate binding pocket [chemical binding]; other site 1193807004579 dimer interface [polypeptide binding]; other site 1193807004580 inhibitor binding site; inhibition site 1193807004581 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1193807004582 catalytic center binding site [active] 1193807004583 ATP binding site [chemical binding]; other site 1193807004584 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1193807004585 active site 1193807004586 recombinase A; Provisional; Region: recA; PRK09354 1193807004587 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1193807004588 hexamer interface [polypeptide binding]; other site 1193807004589 Walker A motif; other site 1193807004590 ATP binding site [chemical binding]; other site 1193807004591 Walker B motif; other site 1193807004592 RecX family; Region: RecX; cl00936 1193807004593 ribonuclease Y; Region: RNase_Y; TIGR03319 1193807004594 KH domain; Region: KH_1; pfam00013 1193807004595 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1193807004596 Zn2+ binding site [ion binding]; other site 1193807004597 Mg2+ binding site [ion binding]; other site 1193807004598 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1193807004599 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1193807004600 putative active site [active] 1193807004601 metal binding site [ion binding]; metal-binding site 1193807004602 homodimer binding site [polypeptide binding]; other site 1193807004603 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1193807004604 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1193807004605 active site 1193807004606 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1193807004607 membrane protein; Provisional; Region: PRK14417 1193807004608 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 1193807004609 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1193807004610 minor groove reading motif; other site 1193807004611 helix-hairpin-helix signature motif; other site 1193807004612 substrate binding pocket [chemical binding]; other site 1193807004613 active site 1193807004614 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1193807004615 homodimer interaction site [polypeptide binding]; other site 1193807004616 cofactor binding site; other site 1193807004617 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 1193807004618 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1193807004619 active site 1193807004620 catalytic residues [active] 1193807004621 metal binding site [ion binding]; metal-binding site 1193807004622 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1193807004623 nucleotide binding site/active site [active] 1193807004624 HIT family signature motif; other site 1193807004625 catalytic residue [active] 1193807004626 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1193807004627 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1193807004628 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1193807004629 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1193807004630 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1193807004631 Walker A/P-loop; other site 1193807004632 ATP binding site [chemical binding]; other site 1193807004633 Q-loop/lid; other site 1193807004634 ABC transporter signature motif; other site 1193807004635 Walker B; other site 1193807004636 D-loop; other site 1193807004637 H-loop/switch region; other site 1193807004638 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1193807004639 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1193807004640 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1193807004641 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 1193807004642 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 1193807004643 trimer interface [polypeptide binding]; other site 1193807004644 putative Zn binding site [ion binding]; other site 1193807004645 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 1193807004646 non-heme iron binding site [ion binding]; other site 1193807004647 dimer interface [polypeptide binding]; other site 1193807004648 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1193807004649 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1193807004650 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1193807004651 TrkA-N domain; Region: TrkA_N; pfam02254 1193807004652 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1193807004653 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 1193807004654 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1193807004655 FeS/SAM binding site; other site 1193807004656 DNA gyrase subunit A; Validated; Region: PRK05560 1193807004657 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1193807004658 CAP-like domain; other site 1193807004659 active site 1193807004660 primary dimer interface [polypeptide binding]; other site 1193807004661 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1193807004662 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1193807004663 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1193807004664 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1193807004665 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1193807004666 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1193807004667 binding surface 1193807004668 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1193807004669 TPR motif; other site 1193807004670 NifU-like domain; Region: NifU; cl00484 1193807004671 aspartate kinase; Reviewed; Region: PRK06635 1193807004672 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 1193807004673 putative catalytic residues [active] 1193807004674 putative nucleotide binding site [chemical binding]; other site 1193807004675 putative aspartate binding site [chemical binding]; other site 1193807004676 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1193807004677 putative allosteric regulatory site; other site 1193807004678 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1193807004679 putative allosteric regulatory residue; other site 1193807004680 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 1193807004681 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 1193807004682 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1193807004683 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1193807004684 homodimer interface [polypeptide binding]; other site 1193807004685 metal binding site [ion binding]; metal-binding site 1193807004686 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1193807004687 homodimer interface [polypeptide binding]; other site 1193807004688 active site 1193807004689 putative chemical substrate binding site [chemical binding]; other site 1193807004690 metal binding site [ion binding]; metal-binding site 1193807004691 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 1193807004692 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1193807004693 LexA repressor; Validated; Region: PRK00215 1193807004694 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1193807004695 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1193807004696 Catalytic site [active] 1193807004697 L-fuculose phosphate aldolase; Provisional; Region: PRK08660 1193807004698 intersubunit interface [polypeptide binding]; other site 1193807004699 active site 1193807004700 Zn2+ binding site [ion binding]; other site 1193807004701 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1193807004702 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1193807004703 putative active site [active] 1193807004704 substrate binding site [chemical binding]; other site 1193807004705 putative cosubstrate binding site; other site 1193807004706 catalytic site [active] 1193807004707 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1193807004708 substrate binding site [chemical binding]; other site