-- dump date 20140619_060134 -- class Genbank::misc_feature -- table misc_feature_note -- id note 552811000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 552811000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 552811000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 552811000004 Walker A motif; other site 552811000005 ATP binding site [chemical binding]; other site 552811000006 Walker B motif; other site 552811000007 arginine finger; other site 552811000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 552811000009 DnaA box-binding interface [nucleotide binding]; other site 552811000010 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 552811000011 Transposase, Mutator family; Region: Transposase_mut; pfam00872 552811000012 MULE transposase domain; Region: MULE; pfam10551 552811000013 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 552811000014 active site 552811000015 dimer interface [polypeptide binding]; other site 552811000016 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 552811000017 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 552811000018 dihydropteroate synthase; Region: DHPS; TIGR01496 552811000019 substrate binding pocket [chemical binding]; other site 552811000020 dimer interface [polypeptide binding]; other site 552811000021 inhibitor binding site; inhibition site 552811000022 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 552811000023 catalytic center binding site [active] 552811000024 ATP binding site [chemical binding]; other site 552811000025 hypothetical protein; Provisional; Region: PRK10279 552811000026 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 552811000027 nucleophile elbow; other site 552811000028 DOMON domain; Region: DOMON; pfam03351 552811000029 DOMON-like domain of copper-dependent monooxygenases and related proteins; Region: DOMON_DOH; cd09631 552811000030 putative ligand binding site [chemical binding]; other site 552811000031 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 552811000032 putative active site [active] 552811000033 metal binding site [ion binding]; metal-binding site 552811000034 homodimer binding site [polypeptide binding]; other site 552811000035 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 552811000036 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 552811000037 active site 552811000038 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 552811000039 membrane protein; Provisional; Region: PRK14417 552811000040 Muconolactone delta-isomerase; Region: MIase; cl01992 552811000041 Response regulator receiver domain; Region: Response_reg; pfam00072 552811000042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552811000043 active site 552811000044 phosphorylation site [posttranslational modification] 552811000045 intermolecular recognition site; other site 552811000046 dimerization interface [polypeptide binding]; other site 552811000047 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 552811000048 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 552811000049 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 552811000050 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 552811000051 FeS/SAM binding site; other site 552811000052 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 552811000053 FeS/SAM binding site; other site 552811000054 Radical SAM superfamily; Region: Radical_SAM; pfam04055 552811000055 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 552811000056 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 552811000057 FeS/SAM binding site; other site 552811000058 Transposase, Mutator family; Region: Transposase_mut; pfam00872 552811000059 MULE transposase domain; Region: MULE; pfam10551 552811000060 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 552811000061 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 552811000062 Ligand Binding Site [chemical binding]; other site 552811000063 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 552811000064 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 552811000065 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 552811000066 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 552811000067 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 552811000068 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 552811000069 pyruvate carboxylase subunit A; Validated; Region: PRK08654 552811000070 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 552811000071 ATP-grasp domain; Region: ATP-grasp_4; cl17255 552811000072 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 552811000073 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 552811000074 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 552811000075 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 552811000076 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 552811000077 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 552811000078 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 552811000079 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 552811000080 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 552811000081 molybdopterin cofactor binding site; other site 552811000082 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 552811000083 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 552811000084 SLBB domain; Region: SLBB; pfam10531 552811000085 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 552811000086 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 552811000087 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 552811000088 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 552811000089 Competence protein; Region: Competence; pfam03772 552811000090 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 552811000091 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 552811000092 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 552811000093 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 552811000094 Methyltransferase domain; Region: Methyltransf_31; pfam13847 552811000095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 552811000096 S-adenosylmethionine binding site [chemical binding]; other site 552811000097 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 552811000098 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 552811000099 NifU-like domain; Region: NifU; pfam01106 552811000100 aspartate kinase; Reviewed; Region: PRK06635 552811000101 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 552811000102 putative catalytic residues [active] 552811000103 putative nucleotide binding site [chemical binding]; other site 552811000104 putative aspartate binding site [chemical binding]; other site 552811000105 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 552811000106 putative allosteric regulatory site; other site 552811000107 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 552811000108 putative allosteric regulatory residue; other site 552811000109 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 552811000110 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 552811000111 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 552811000112 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 552811000113 homodimer interface [polypeptide binding]; other site 552811000114 metal binding site [ion binding]; metal-binding site 552811000115 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 552811000116 homodimer interface [polypeptide binding]; other site 552811000117 active site 552811000118 putative chemical substrate binding site [chemical binding]; other site 552811000119 metal binding site [ion binding]; metal-binding site 552811000120 Winged helix-turn helix; Region: HTH_29; pfam13551 552811000121 Homeodomain-like domain; Region: HTH_32; pfam13565 552811000122 Integrase core domain; Region: rve; pfam00665 552811000123 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 552811000124 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 552811000125 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 552811000126 putative active site [active] 552811000127 heme pocket [chemical binding]; other site 552811000128 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 552811000129 dimer interface [polypeptide binding]; other site 552811000130 phosphorylation site [posttranslational modification] 552811000131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552811000132 ATP binding site [chemical binding]; other site 552811000133 Mg2+ binding site [ion binding]; other site 552811000134 G-X-G motif; other site 552811000135 Response regulator receiver domain; Region: Response_reg; pfam00072 552811000136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552811000137 active site 552811000138 phosphorylation site [posttranslational modification] 552811000139 intermolecular recognition site; other site 552811000140 dimerization interface [polypeptide binding]; other site 552811000141 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 552811000142 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 552811000143 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 552811000144 ABC transporter; Region: ABC_tran_2; pfam12848 552811000145 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 552811000146 hybrid cluster protein; Provisional; Region: PRK05290 552811000147 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 552811000148 ACS interaction site; other site 552811000149 CODH interaction site; other site 552811000150 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 552811000151 ACS interaction site; other site 552811000152 CODH interaction site; other site 552811000153 metal cluster binding site [ion binding]; other site 552811000154 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 552811000155 Ligand Binding Site [chemical binding]; other site 552811000156 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 552811000157 Ligand Binding Site [chemical binding]; other site 552811000158 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 552811000159 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 552811000160 nucleotide binding site [chemical binding]; other site 552811000161 NEF interaction site [polypeptide binding]; other site 552811000162 SBD interface [polypeptide binding]; other site 552811000163 GrpE; Region: GrpE; pfam01025 552811000164 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 552811000165 dimer interface [polypeptide binding]; other site 552811000166 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 552811000167 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 552811000168 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 552811000169 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 552811000170 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 552811000171 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 552811000172 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 552811000173 intersubunit interface [polypeptide binding]; other site 552811000174 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 552811000175 metal binding site 2 [ion binding]; metal-binding site 552811000176 putative DNA binding helix; other site 552811000177 metal binding site 1 [ion binding]; metal-binding site 552811000178 dimer interface [polypeptide binding]; other site 552811000179 structural Zn2+ binding site [ion binding]; other site 552811000180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 552811000181 Major Facilitator Superfamily; Region: MFS_1; pfam07690 552811000182 putative substrate translocation pore; other site 552811000183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 552811000184 putative substrate translocation pore; other site 552811000185 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 552811000186 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 552811000187 heterodimer interface [polypeptide binding]; other site 552811000188 active site 552811000189 FMN binding site [chemical binding]; other site 552811000190 homodimer interface [polypeptide binding]; other site 552811000191 substrate binding site [chemical binding]; other site 552811000192 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 552811000193 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 552811000194 reductive dehalogenase; Region: RDH; TIGR02486 552811000195 Transposase, Mutator family; Region: Transposase_mut; pfam00872 552811000196 MULE transposase domain; Region: MULE; pfam10551 552811000197 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 552811000198 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 552811000199 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 552811000200 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 552811000201 ABC-ATPase subunit interface; other site 552811000202 dimer interface [polypeptide binding]; other site 552811000203 putative PBP binding regions; other site 552811000204 FOG: WD40 repeat [General function prediction only]; Region: COG2319 552811000205 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 552811000206 Cytokine receptor motif; other site 552811000207 Transposase domain (DUF772); Region: DUF772; pfam05598 552811000208 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 552811000209 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 552811000210 Fic/DOC family; Region: Fic; cl00960 552811000211 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 552811000212 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 552811000213 DNA methylase; Region: N6_N4_Mtase; pfam01555 552811000214 Transposase domain (DUF772); Region: DUF772; pfam05598 552811000215 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 552811000216 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 552811000217 hypothetical protein; Provisional; Region: PRK04323 552811000218 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 552811000219 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 552811000220 catalytic site [active] 552811000221 G-X2-G-X-G-K; other site 552811000222 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 552811000223 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 552811000224 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 552811000225 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 552811000226 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 552811000227 TrkA-N domain; Region: TrkA_N; pfam02254 552811000228 TrkA-C domain; Region: TrkA_C; pfam02080 552811000229 TrkA-N domain; Region: TrkA_N; pfam02254 552811000230 TrkA-C domain; Region: TrkA_C; pfam02080 552811000231 Cation transport protein; Region: TrkH; cl17365 552811000232 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 552811000233 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 552811000234 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 552811000235 Rubrerythrin [Energy production and conversion]; Region: COG1592 552811000236 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 552811000237 binuclear metal center [ion binding]; other site 552811000238 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 552811000239 iron binding site [ion binding]; other site 552811000240 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 552811000241 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 552811000242 active site 552811000243 NTP binding site [chemical binding]; other site 552811000244 metal binding triad [ion binding]; metal-binding site 552811000245 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 552811000246 DNA polymerase I; Provisional; Region: PRK05755 552811000247 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 552811000248 active site 552811000249 metal binding site 1 [ion binding]; metal-binding site 552811000250 putative 5' ssDNA interaction site; other site 552811000251 metal binding site 3; metal-binding site 552811000252 metal binding site 2 [ion binding]; metal-binding site 552811000253 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 552811000254 putative DNA binding site [nucleotide binding]; other site 552811000255 putative metal binding site [ion binding]; other site 552811000256 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 552811000257 active site 552811000258 catalytic site [active] 552811000259 substrate binding site [chemical binding]; other site 552811000260 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 552811000261 active site 552811000262 DNA binding site [nucleotide binding] 552811000263 catalytic site [active] 552811000264 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 552811000265 active site 552811000266 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 552811000267 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 552811000268 DNA binding site [nucleotide binding] 552811000269 catalytic residue [active] 552811000270 H2TH interface [polypeptide binding]; other site 552811000271 putative catalytic residues [active] 552811000272 turnover-facilitating residue; other site 552811000273 intercalation triad [nucleotide binding]; other site 552811000274 8OG recognition residue [nucleotide binding]; other site 552811000275 putative reading head residues; other site 552811000276 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 552811000277 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 552811000278 EamA-like transporter family; Region: EamA; cl17759 552811000279 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 552811000280 Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins [General function prediction only]; Region: PflX; COG1313 552811000281 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 552811000282 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 552811000283 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 552811000284 HIGH motif; other site 552811000285 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 552811000286 active site 552811000287 KMSKS motif; other site 552811000288 RDD family; Region: RDD; pfam06271 552811000289 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 552811000290 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 552811000291 RNA binding surface [nucleotide binding]; other site 552811000292 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 552811000293 active site 552811000294 lipoprotein signal peptidase; Provisional; Region: PRK14784 552811000295 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 552811000296 ornithine carbamoyltransferase; Provisional; Region: PRK00779 552811000297 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 552811000298 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 552811000299 GTP-binding protein Der; Reviewed; Region: PRK00093 552811000300 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 552811000301 G1 box; other site 552811000302 GTP/Mg2+ binding site [chemical binding]; other site 552811000303 Switch I region; other site 552811000304 G2 box; other site 552811000305 Switch II region; other site 552811000306 G3 box; other site 552811000307 G4 box; other site 552811000308 G5 box; other site 552811000309 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 552811000310 G1 box; other site 552811000311 GTP/Mg2+ binding site [chemical binding]; other site 552811000312 Switch I region; other site 552811000313 G2 box; other site 552811000314 G3 box; other site 552811000315 Switch II region; other site 552811000316 G4 box; other site 552811000317 G5 box; other site 552811000318 membrane protein; Provisional; Region: PRK14415 552811000319 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 552811000320 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 552811000321 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 552811000322 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 552811000323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 552811000324 S-adenosylmethionine binding site [chemical binding]; other site 552811000325 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 552811000326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 552811000327 S-adenosylmethionine binding site [chemical binding]; other site 552811000328 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 552811000329 active site 552811000330 NAD binding site [chemical binding]; other site 552811000331 metal binding site [ion binding]; metal-binding site 552811000332 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 552811000333 UbiA prenyltransferase family; Region: UbiA; pfam01040 552811000334 Methyltransferase domain; Region: Methyltransf_31; pfam13847 552811000335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 552811000336 S-adenosylmethionine binding site [chemical binding]; other site 552811000337 Yqey-like protein; Region: YqeY; pfam09424 552811000338 Transcriptional regulators [Transcription]; Region: MarR; COG1846 552811000339 MarR family; Region: MarR_2; pfam12802 552811000340 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 552811000341 reductive dehalogenase; Region: RDH; TIGR02486 552811000342 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 552811000343 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 552811000344 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 552811000345 FeS/SAM binding site; other site 552811000346 Uncharacterized conserved protein [Function unknown]; Region: COG1432 552811000347 LabA_like proteins; Region: LabA_like; cd06167 552811000348 putative metal binding site [ion binding]; other site 552811000349 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 552811000350 Putative zinc ribbon domain; Region: DUF164; pfam02591 552811000351 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 552811000352 RNA/DNA hybrid binding site [nucleotide binding]; other site 552811000353 active site 552811000354 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 552811000355 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 552811000356 FeoA domain; Region: FeoA; pfam04023 552811000357 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 552811000358 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 552811000359 G1 box; other site 552811000360 GTP/Mg2+ binding site [chemical binding]; other site 552811000361 Switch I region; other site 552811000362 G2 box; other site 552811000363 G3 box; other site 552811000364 Switch II region; other site 552811000365 G4 box; other site 552811000366 G5 box; other site 552811000367 Nucleoside recognition; Region: Gate; pfam07670 552811000368 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 552811000369 Nucleoside recognition; Region: Gate; pfam07670 552811000370 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 552811000371 metal binding site 2 [ion binding]; metal-binding site 552811000372 putative DNA binding helix; other site 552811000373 metal binding site 1 [ion binding]; metal-binding site 552811000374 dimer interface [polypeptide binding]; other site 552811000375 structural Zn2+ binding site [ion binding]; other site 552811000376 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 552811000377 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 552811000378 trimer interface [polypeptide binding]; other site 552811000379 active site 552811000380 substrate binding site [chemical binding]; other site 552811000381 CoA binding site [chemical binding]; other site 552811000382 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 552811000383 Quinolinate synthetase A protein; Region: NadA; pfam02445 552811000384 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 552811000385 Methyltransferase domain; Region: Methyltransf_23; pfam13489 552811000386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 552811000387 S-adenosylmethionine binding site [chemical binding]; other site 552811000388 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 552811000389 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 552811000390 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 552811000391 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 552811000392 phosphate binding site [ion binding]; other site 552811000393 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 552811000394 PAS domain S-box; Region: sensory_box; TIGR00229 552811000395 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 552811000396 putative active site [active] 552811000397 heme pocket [chemical binding]; other site 552811000398 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 552811000399 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 552811000400 putative active site [active] 552811000401 heme pocket [chemical binding]; other site 552811000402 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 552811000403 dimer interface [polypeptide binding]; other site 552811000404 phosphorylation site [posttranslational modification] 552811000405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552811000406 ATP binding site [chemical binding]; other site 552811000407 Mg2+ binding site [ion binding]; other site 552811000408 G-X-G motif; other site 552811000409 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 552811000410 active site 552811000411 FMN binding site [chemical binding]; other site 552811000412 substrate binding site [chemical binding]; other site 552811000413 3Fe-4S cluster binding site [ion binding]; other site 552811000414 methionine sulfoxide reductase B; Provisional; Region: PRK05508 552811000415 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 552811000416 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 552811000417 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 552811000418 pyridoxal 5'-phosphate binding site [chemical binding]; other site 552811000419 homodimer interface [polypeptide binding]; other site 552811000420 catalytic residue [active] 552811000421 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 552811000422 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 552811000423 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 552811000424 nucleotide binding site/active site [active] 552811000425 HIT family signature motif; other site 552811000426 catalytic residue [active] 552811000427 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 552811000428 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 552811000429 YcfA-like protein; Region: YcfA; cl00752 552811000430 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 552811000431 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 552811000432 Beta-Casp domain; Region: Beta-Casp; smart01027 552811000433 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 552811000434 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 552811000435 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 552811000436 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 552811000437 glutamate synthase (NADPH), homotetrameric; Region: gltA; TIGR01316 552811000438 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 552811000439 4Fe-4S binding domain; Region: Fer4; pfam00037 552811000440 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 552811000441 Ligand Binding Site [chemical binding]; other site 552811000442 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 552811000443 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 552811000444 Protein of unknown function, DUF485; Region: DUF485; pfam04341 552811000445 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 552811000446 Ligand Binding Site [chemical binding]; other site 552811000447 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 552811000448 reductive dehalogenase; Region: RDH; TIGR02486 552811000449 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 552811000450 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 552811000451 GIY-YIG motif/motif A; other site 552811000452 putative active site [active] 552811000453 putative metal binding site [ion binding]; other site 552811000454 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 552811000455 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 552811000456 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 552811000457 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 552811000458 putative active site [active] 552811000459 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 552811000460 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 552811000461 PemK-like protein; Region: PemK; pfam02452 552811000462 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 552811000463 Predicted RNA binding protein (dsRBD-like fold), HicA family [General function prediction only]; Region: COG1724 552811000464 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 552811000465 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 552811000466 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 552811000467 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 552811000468 dinuclear metal binding motif [ion binding]; other site 552811000469 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 552811000470 non-specific DNA binding site [nucleotide binding]; other site 552811000471 salt bridge; other site 552811000472 sequence-specific DNA binding site [nucleotide binding]; other site 552811000473 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 552811000474 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 552811000475 DNA-binding interface [nucleotide binding]; DNA binding site 552811000476 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 552811000477 Transposase, Mutator family; Region: Transposase_mut; pfam00872 552811000478 MULE transposase domain; Region: MULE; pfam10551 552811000479 YcfA-like protein; Region: YcfA; pfam07927 552811000480 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 552811000481 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 552811000482 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 552811000483 dinuclear metal binding motif [ion binding]; other site 552811000484 prolyl-tRNA synthetase; Provisional; Region: PRK09194 552811000485 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 552811000486 dimer interface [polypeptide binding]; other site 552811000487 motif 1; other site 552811000488 active site 552811000489 motif 2; other site 552811000490 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 552811000491 putative deacylase active site [active] 552811000492 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 552811000493 active site 552811000494 motif 3; other site 552811000495 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 552811000496 anticodon binding site; other site 552811000497 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 552811000498 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 552811000499 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 552811000500 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 552811000501 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 552811000502 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 552811000503 active site 552811000504 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 552811000505 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 552811000506 putative substrate binding region [chemical binding]; other site 552811000507 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 552811000508 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 552811000509 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 552811000510 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 552811000511 Flagellin N-methylase; Region: FliB; pfam03692 552811000512 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 552811000513 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 552811000514 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 552811000515 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 552811000516 catalytic residue [active] 552811000517 putative FPP diphosphate binding site; other site 552811000518 putative FPP binding hydrophobic cleft; other site 552811000519 dimer interface [polypeptide binding]; other site 552811000520 putative IPP diphosphate binding site; other site 552811000521 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 552811000522 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 552811000523 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 552811000524 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 552811000525 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 552811000526 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 552811000527 active site 552811000528 multimer interface [polypeptide binding]; other site 552811000529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 552811000530 Major Facilitator Superfamily; Region: MFS_1; pfam07690 552811000531 putative substrate translocation pore; other site 552811000532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 552811000533 putative substrate translocation pore; other site 552811000534 hypothetical protein; Validated; Region: PRK00110 552811000535 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 552811000536 active site 552811000537 putative DNA-binding cleft [nucleotide binding]; other site 552811000538 dimer interface [polypeptide binding]; other site 552811000539 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 552811000540 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 552811000541 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 552811000542 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 552811000543 Fe-S cluster binding site [ion binding]; other site 552811000544 active site 552811000545 Transposase, Mutator family; Region: Transposase_mut; pfam00872 552811000546 MULE transposase domain; Region: MULE; pfam10551 552811000547 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 552811000548 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 552811000549 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 552811000550 prephenate dehydrogenase; Validated; Region: PRK08507 552811000551 Chorismate mutase type II; Region: CM_2; smart00830 552811000552 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 552811000553 Prephenate dehydratase; Region: PDT; pfam00800 552811000554 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 552811000555 putative L-Phe binding site [chemical binding]; other site 552811000556 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 552811000557 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 552811000558 Tetramer interface [polypeptide binding]; other site 552811000559 active site 552811000560 FMN-binding site [chemical binding]; other site 552811000561 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 552811000562 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 552811000563 hinge; other site 552811000564 active site 552811000565 shikimate kinase; Reviewed; Region: aroK; PRK00131 552811000566 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 552811000567 ADP binding site [chemical binding]; other site 552811000568 magnesium binding site [ion binding]; other site 552811000569 putative shikimate binding site; other site 552811000570 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 552811000571 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 552811000572 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 552811000573 shikimate binding site; other site 552811000574 NAD(P) binding site [chemical binding]; other site 552811000575 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 552811000576 active site 552811000577 catalytic residue [active] 552811000578 dimer interface [polypeptide binding]; other site 552811000579 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 552811000580 active site 552811000581 dimer interface [polypeptide binding]; other site 552811000582 metal binding site [ion binding]; metal-binding site 552811000583 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 552811000584 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 552811000585 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 552811000586 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 552811000587 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 552811000588 catalytic loop [active] 552811000589 iron binding site [ion binding]; other site 552811000590 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 552811000591 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 552811000592 [4Fe-4S] binding site [ion binding]; other site 552811000593 molybdopterin cofactor binding site; other site 552811000594 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 552811000595 molybdopterin cofactor binding site; other site 552811000596 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 552811000597 dimer interface [polypeptide binding]; other site 552811000598 [2Fe-2S] cluster binding site [ion binding]; other site 552811000599 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 552811000600 SLBB domain; Region: SLBB; pfam10531 552811000601 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 552811000602 4Fe-4S binding domain; Region: Fer4; pfam00037 552811000603 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 552811000604 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 552811000605 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 552811000606 putative dimer interface [polypeptide binding]; other site 552811000607 [2Fe-2S] cluster binding site [ion binding]; other site 552811000608 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 552811000609 HsdM N-terminal domain; Region: HsdM_N; pfam12161 552811000610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 552811000611 S-adenosylmethionine binding site [chemical binding]; other site 552811000612 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 552811000613 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 552811000614 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 552811000615 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 552811000616 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 552811000617 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 552811000618 ATP binding site [chemical binding]; other site 552811000619 putative Mg++ binding site [ion binding]; other site 552811000620 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 552811000621 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 552811000622 NAD(P) binding site [chemical binding]; other site 552811000623 active site 552811000624 EDD domain protein, DegV family; Region: DegV; TIGR00762 552811000625 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 552811000626 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 552811000627 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 552811000628 dimer interface [polypeptide binding]; other site 552811000629 pyridoxal 5'-phosphate binding site [chemical binding]; other site 552811000630 catalytic residue [active] 552811000631 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 552811000632 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 552811000633 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 552811000634 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 552811000635 putative acyl-acceptor binding pocket; other site 552811000636 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 552811000637 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 552811000638 catalytic residues [active] 552811000639 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 552811000640 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 552811000641 catalytic residues [active] 552811000642 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 552811000643 protein binding site [polypeptide binding]; other site 552811000644 Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119 552811000645 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 552811000646 YtxH-like protein; Region: YtxH; pfam12732 552811000647 AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061 552811000648 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309 552811000649 dimerization interface [polypeptide binding]; other site 552811000650 putative ATP binding site [chemical binding]; other site 552811000651 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 552811000652 thiamine phosphate binding site [chemical binding]; other site 552811000653 active site 552811000654 pyrophosphate binding site [ion binding]; other site 552811000655 Uncharacterized conserved protein [Function unknown]; Region: COG0062 552811000656 putative carbohydrate kinase; Provisional; Region: PRK10565 552811000657 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 552811000658 putative substrate binding site [chemical binding]; other site 552811000659 putative ATP binding site [chemical binding]; other site 552811000660 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 552811000661 nucleotide binding site [chemical binding]; other site 552811000662 Type III pantothenate kinase; Region: Pan_kinase; cl17198 552811000663 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 552811000664 Flavoprotein; Region: Flavoprotein; pfam02441 552811000665 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 552811000666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552811000667 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 552811000668 active site 552811000669 phosphorylation site [posttranslational modification] 552811000670 intermolecular recognition site; other site 552811000671 dimerization interface [polypeptide binding]; other site 552811000672 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 552811000673 DNA binding residues [nucleotide binding] 552811000674 dimerization interface [polypeptide binding]; other site 552811000675 PRC-barrel domain; Region: PRC; pfam05239 552811000676 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 552811000677 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 552811000678 DAK2 domain; Region: Dak2; pfam02734 552811000679 membrane protein; Provisional; Region: PRK14417 552811000680 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 552811000681 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 552811000682 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 552811000683 Transposase, Mutator family; Region: Transposase_mut; pfam00872 552811000684 MULE transposase domain; Region: MULE; pfam10551 552811000685 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 552811000686 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 552811000687 dimerization interface [polypeptide binding]; other site 552811000688 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 552811000689 dimer interface [polypeptide binding]; other site 552811000690 phosphorylation site [posttranslational modification] 552811000691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552811000692 ATP binding site [chemical binding]; other site 552811000693 Mg2+ binding site [ion binding]; other site 552811000694 G-X-G motif; other site 552811000695 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 552811000696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552811000697 active site 552811000698 phosphorylation site [posttranslational modification] 552811000699 intermolecular recognition site; other site 552811000700 dimerization interface [polypeptide binding]; other site 552811000701 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 552811000702 DNA binding site [nucleotide binding] 552811000703 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 552811000704 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 552811000705 putative active site [active] 552811000706 heme pocket [chemical binding]; other site 552811000707 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 552811000708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552811000709 ATP binding site [chemical binding]; other site 552811000710 Mg2+ binding site [ion binding]; other site 552811000711 G-X-G motif; other site 552811000712 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 552811000713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552811000714 active site 552811000715 phosphorylation site [posttranslational modification] 552811000716 intermolecular recognition site; other site 552811000717 dimerization interface [polypeptide binding]; other site 552811000718 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 552811000719 DNA binding residues [nucleotide binding] 552811000720 dimerization interface [polypeptide binding]; other site 552811000721 Transposase; Region: HTH_Tnp_1; cl17663 552811000722 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 552811000723 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 552811000724 reductive dehalogenase; Region: RDH; TIGR02486 552811000725 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 552811000726 reductive dehalogenase; Region: RDH; TIGR02486 552811000727 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 552811000728 Transposase; Region: HTH_Tnp_1; pfam01527 552811000729 putative transposase OrfB; Reviewed; Region: PHA02517 552811000730 Integrase core domain; Region: rve; pfam00665 552811000731 Integrase core domain; Region: rve_3; pfam13683 552811000732 HTH-like domain; Region: HTH_21; pfam13276 552811000733 Transposase; Region: HTH_Tnp_1; cl17663 552811000734 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 552811000735 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 552811000736 reductive dehalogenase; Region: RDH; TIGR02486 552811000737 Transposase, Mutator family; Region: Transposase_mut; pfam00872 552811000738 MULE transposase domain; Region: MULE; pfam10551 552811000739 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 552811000740 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 552811000741 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 552811000742 Adenylate kinase; Region: ADK; pfam00406 552811000743 active site 552811000744 Probable zinc-binding domain; Region: zf-trcl; pfam13451 552811000745 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 552811000746 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 552811000747 Transposase domain (DUF772); Region: DUF772; pfam05598 552811000748 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 552811000749 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 552811000750 Helix-turn-helix domain; Region: HTH_17; pfam12728 552811000751 Response regulator receiver domain; Region: Response_reg; pfam00072 552811000752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552811000753 active site 552811000754 phosphorylation site [posttranslational modification] 552811000755 intermolecular recognition site; other site 552811000756 dimerization interface [polypeptide binding]; other site 552811000757 PAS domain S-box; Region: sensory_box; TIGR00229 552811000758 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 552811000759 putative active site [active] 552811000760 heme pocket [chemical binding]; other site 552811000761 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 552811000762 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 552811000763 putative active site [active] 552811000764 heme pocket [chemical binding]; other site 552811000765 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 552811000766 dimer interface [polypeptide binding]; other site 552811000767 phosphorylation site [posttranslational modification] 552811000768 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552811000769 ATP binding site [chemical binding]; other site 552811000770 Mg2+ binding site [ion binding]; other site 552811000771 G-X-G motif; other site 552811000772 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 552811000773 Competence-damaged protein; Region: CinA; pfam02464 552811000774 ribonuclease PH; Reviewed; Region: rph; PRK00173 552811000775 Ribonuclease PH; Region: RNase_PH_bact; cd11362 552811000776 hexamer interface [polypeptide binding]; other site 552811000777 active site 552811000778 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 552811000779 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 552811000780 putative catalytic cysteine [active] 552811000781 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 552811000782 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 552811000783 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 552811000784 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 552811000785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 552811000786 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 552811000787 NAD(P) binding site [chemical binding]; other site 552811000788 active site 552811000789 transcription antitermination factor NusB; Region: nusB; TIGR01951 552811000790 putative RNA binding site [nucleotide binding]; other site 552811000791 acyl carrier protein; Provisional; Region: acpP; PRK00982 552811000792 gamma-glutamyl kinase; Provisional; Region: PRK05429 552811000793 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 552811000794 nucleotide binding site [chemical binding]; other site 552811000795 homotetrameric interface [polypeptide binding]; other site 552811000796 putative phosphate binding site [ion binding]; other site 552811000797 putative allosteric binding site; other site 552811000798 PUA domain; Region: PUA; pfam01472 552811000799 Methyltransferase domain; Region: Methyltransf_31; pfam13847 552811000800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 552811000801 S-adenosylmethionine binding site [chemical binding]; other site 552811000802 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 552811000803 Ligand Binding Site [chemical binding]; other site 552811000804 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 552811000805 Ligand Binding Site [chemical binding]; other site 552811000806 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 552811000807 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 552811000808 Walker A motif; other site 552811000809 ATP binding site [chemical binding]; other site 552811000810 Walker B motif; other site 552811000811 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 552811000812 RNA recognition motif; Region: RRM; smart00360 552811000813 Probable zinc-binding domain; Region: zf-trcl; pfam13451 552811000814 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 552811000815 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 552811000816 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 552811000817 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 552811000818 DNA protecting protein DprA; Region: dprA; TIGR00732 552811000819 Adenosine deaminase z-alpha domain; Region: z-alpha; cl02659 552811000820 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 552811000821 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 552811000822 ATP binding site [chemical binding]; other site 552811000823 putative Mg++ binding site [ion binding]; other site 552811000824 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 552811000825 nucleotide binding region [chemical binding]; other site 552811000826 ATP-binding site [chemical binding]; other site 552811000827 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 552811000828 homotrimer interaction site [polypeptide binding]; other site 552811000829 putative active site [active] 552811000830 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 552811000831 active site 552811000832 DEAD-like helicases superfamily; Region: DEXDc; smart00487 552811000833 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 552811000834 ATP binding site [chemical binding]; other site 552811000835 putative Mg++ binding site [ion binding]; other site 552811000836 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 552811000837 Transposase domain (DUF772); Region: DUF772; pfam05598 552811000838 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 552811000839 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 552811000840 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 552811000841 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 552811000842 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 552811000843 HsdM N-terminal domain; Region: HsdM_N; pfam12161 552811000844 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 552811000845 Methyltransferase domain; Region: Methyltransf_26; pfam13659 552811000846 Domain found in IF2B/IF5; Region: eIF-5_eIF-2B; cl17014 552811000847 Protein of unknown function (DUF2769); Region: DUF2769; pfam10967 552811000848 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 552811000849 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 552811000850 Rubredoxin; Region: Rubredoxin; pfam00301 552811000851 iron binding site [ion binding]; other site 552811000852 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 552811000853 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 552811000854 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 552811000855 dimer interface [polypeptide binding]; other site 552811000856 PYR/PP interface [polypeptide binding]; other site 552811000857 TPP binding site [chemical binding]; other site 552811000858 substrate binding site [chemical binding]; other site 552811000859 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778 552811000860 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 552811000861 TPP-binding site [chemical binding]; other site 552811000862 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 552811000863 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 552811000864 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 552811000865 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 552811000866 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 552811000867 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 552811000868 putative ADP-binding pocket [chemical binding]; other site 552811000869 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 552811000870 elongation factor Tu; Reviewed; Region: PRK12735 552811000871 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 552811000872 G1 box; other site 552811000873 GEF interaction site [polypeptide binding]; other site 552811000874 GTP/Mg2+ binding site [chemical binding]; other site 552811000875 Switch I region; other site 552811000876 G2 box; other site 552811000877 G3 box; other site 552811000878 Switch II region; other site 552811000879 G4 box; other site 552811000880 G5 box; other site 552811000881 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 552811000882 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 552811000883 Antibiotic Binding Site [chemical binding]; other site 552811000884 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 552811000885 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 552811000886 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 552811000887 putative homodimer interface [polypeptide binding]; other site 552811000888 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 552811000889 heterodimer interface [polypeptide binding]; other site 552811000890 homodimer interface [polypeptide binding]; other site 552811000891 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 552811000892 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 552811000893 putative thiostrepton binding site; other site 552811000894 23S rRNA interface [nucleotide binding]; other site 552811000895 L7/L12 interface [polypeptide binding]; other site 552811000896 L25 interface [polypeptide binding]; other site 552811000897 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 552811000898 mRNA/rRNA interface [nucleotide binding]; other site 552811000899 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 552811000900 23S rRNA interface [nucleotide binding]; other site 552811000901 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 552811000902 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 552811000903 core dimer interface [polypeptide binding]; other site 552811000904 peripheral dimer interface [polypeptide binding]; other site 552811000905 L10 interface [polypeptide binding]; other site 552811000906 L11 interface [polypeptide binding]; other site 552811000907 putative EF-Tu interaction site [polypeptide binding]; other site 552811000908 putative EF-G interaction site [polypeptide binding]; other site 552811000909 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 552811000910 Ligand Binding Site [chemical binding]; other site 552811000911 Universal stress protein family; Region: Usp; pfam00582 552811000912 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 552811000913 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 552811000914 CoA-binding site [chemical binding]; other site 552811000915 ATP-binding [chemical binding]; other site 552811000916 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 552811000917 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 552811000918 putative NAD(P) binding site [chemical binding]; other site 552811000919 active site 552811000920 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 552811000921 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 552811000922 FeS/SAM binding site; other site 552811000923 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 552811000924 putative ligand binding pocket/active site [active] 552811000925 putative metal binding site [ion binding]; other site 552811000926 AMMECR1; Region: AMMECR1; pfam01871 552811000927 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 552811000928 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 552811000929 recombination factor protein RarA; Reviewed; Region: PRK13342 552811000930 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 552811000931 Walker A motif; other site 552811000932 ATP binding site [chemical binding]; other site 552811000933 Walker B motif; other site 552811000934 arginine finger; other site 552811000935 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 552811000936 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 552811000937 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 552811000938 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 552811000939 pyruvate carboxylase subunit B; Validated; Region: PRK09282 552811000940 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 552811000941 active site 552811000942 catalytic residues [active] 552811000943 metal binding site [ion binding]; metal-binding site 552811000944 homodimer binding site [polypeptide binding]; other site 552811000945 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 552811000946 carboxyltransferase (CT) interaction site; other site 552811000947 biotinylation site [posttranslational modification]; other site 552811000948 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 552811000949 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 552811000950 substrate binding site [chemical binding]; other site 552811000951 ligand binding site [chemical binding]; other site 552811000952 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 552811000953 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 552811000954 substrate binding site [chemical binding]; other site 552811000955 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 552811000956 isocitrate dehydrogenase; Validated; Region: PRK07362 552811000957 malate dehydrogenase; Reviewed; Region: PRK06223 552811000958 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 552811000959 NAD(P) binding site [chemical binding]; other site 552811000960 dimer interface [polypeptide binding]; other site 552811000961 tetramer (dimer of dimers) interface [polypeptide binding]; other site 552811000962 substrate binding site [chemical binding]; other site 552811000963 fumarate hydratase; Provisional; Region: PRK06246 552811000964 Fumarase C-terminus; Region: Fumerase_C; cl00795 552811000965 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 552811000966 nucleotide binding site/active site [active] 552811000967 HIT family signature motif; other site 552811000968 catalytic residue [active] 552811000969 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 552811000970 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 552811000971 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 552811000972 dimer interface [polypeptide binding]; other site 552811000973 ADP-ribose binding site [chemical binding]; other site 552811000974 active site 552811000975 nudix motif; other site 552811000976 metal binding site [ion binding]; metal-binding site 552811000977 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 552811000978 Coenzyme A binding pocket [chemical binding]; other site 552811000979 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 552811000980 ATP-NAD kinase; Region: NAD_kinase; pfam01513 552811000981 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 552811000982 active site 2 [active] 552811000983 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 552811000984 active site 2 [active] 552811000985 active site 1 [active] 552811000986 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 552811000987 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 552811000988 PAC2 family; Region: PAC2; cl00847 552811000989 HEAT repeats; Region: HEAT_2; pfam13646 552811000990 HEAT repeats; Region: HEAT_2; pfam13646 552811000991 HEAT repeat; Region: HEAT; pfam02985 552811000992 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 552811000993 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 552811000994 FeS/SAM binding site; other site 552811000995 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 552811000996 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 552811000997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552811000998 dimer interface [polypeptide binding]; other site 552811000999 conserved gate region; other site 552811001000 putative PBP binding loops; other site 552811001001 ABC-ATPase subunit interface; other site 552811001002 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 552811001003 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 552811001004 Walker A/P-loop; other site 552811001005 ATP binding site [chemical binding]; other site 552811001006 Q-loop/lid; other site 552811001007 ABC transporter signature motif; other site 552811001008 Walker B; other site 552811001009 D-loop; other site 552811001010 H-loop/switch region; other site 552811001011 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 552811001012 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 552811001013 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 552811001014 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 552811001015 trimerization site [polypeptide binding]; other site 552811001016 active site 552811001017 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 552811001018 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 552811001019 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 552811001020 catalytic residue [active] 552811001021 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 552811001022 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 552811001023 dimer interface [polypeptide binding]; other site 552811001024 pyridoxal 5'-phosphate binding site [chemical binding]; other site 552811001025 catalytic residue [active] 552811001026 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 552811001027 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 552811001028 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 552811001029 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 552811001030 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 552811001031 homodimer interface [polypeptide binding]; other site 552811001032 substrate-cofactor binding pocket; other site 552811001033 pyridoxal 5'-phosphate binding site [chemical binding]; other site 552811001034 catalytic residue [active] 552811001035 Predicted transcriptional regulator [Transcription]; Region: COG1959 552811001036 Transcriptional regulator; Region: Rrf2; cl17282 552811001037 Response regulator receiver domain; Region: Response_reg; pfam00072 552811001038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552811001039 active site 552811001040 phosphorylation site [posttranslational modification] 552811001041 intermolecular recognition site; other site 552811001042 dimerization interface [polypeptide binding]; other site 552811001043 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 552811001044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552811001045 ATP binding site [chemical binding]; other site 552811001046 Mg2+ binding site [ion binding]; other site 552811001047 G-X-G motif; other site 552811001048 Transposase domain (DUF772); Region: DUF772; pfam05598 552811001049 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 552811001050 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 552811001051 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 552811001052 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 552811001053 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 552811001054 putative active site [active] 552811001055 heme pocket [chemical binding]; other site 552811001056 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 552811001057 putative active site [active] 552811001058 heme pocket [chemical binding]; other site 552811001059 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 552811001060 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 552811001061 motif II; other site 552811001062 alpha-mannosidase; Provisional; Region: PRK09819 552811001063 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 552811001064 active site 552811001065 catalytic site [active] 552811001066 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 552811001067 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 552811001068 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 552811001069 FeS/SAM binding site; other site 552811001070 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 552811001071 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 552811001072 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 552811001073 Probable Catalytic site; other site 552811001074 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 552811001075 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 552811001076 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 552811001077 active site 552811001078 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 552811001079 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 552811001080 active site 552811001081 tetramer interface [polypeptide binding]; other site 552811001082 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 552811001083 active site 552811001084 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 552811001085 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 552811001086 Radical SAM superfamily; Region: Radical_SAM; pfam04055 552811001087 FeS/SAM binding site; other site 552811001088 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 552811001089 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 552811001090 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 552811001091 Walker A/P-loop; other site 552811001092 ATP binding site [chemical binding]; other site 552811001093 Q-loop/lid; other site 552811001094 ABC transporter signature motif; other site 552811001095 Walker B; other site 552811001096 D-loop; other site 552811001097 H-loop/switch region; other site 552811001098 Transposase domain (DUF772); Region: DUF772; pfam05598 552811001099 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 552811001100 DDE superfamily endonuclease; Region: DDE_4; cl17710 552811001101 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 552811001102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552811001103 dimer interface [polypeptide binding]; other site 552811001104 conserved gate region; other site 552811001105 ABC-ATPase subunit interface; other site 552811001106 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 552811001107 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 552811001108 Walker A/P-loop; other site 552811001109 ATP binding site [chemical binding]; other site 552811001110 Q-loop/lid; other site 552811001111 ABC transporter signature motif; other site 552811001112 Walker B; other site 552811001113 D-loop; other site 552811001114 H-loop/switch region; other site 552811001115 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 552811001116 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 552811001117 Probable zinc-binding domain; Region: zf-trcl; pfam13451 552811001118 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 552811001119 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 552811001120 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 552811001121 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 552811001122 FeS/SAM binding site; other site 552811001123 Repressor of nif and glnA expression [Transcription]; Region: COG1693 552811001124 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 552811001125 Domain of unknown function DUF128; Region: DUF128; pfam01995 552811001126 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 552811001127 diiron binding motif [ion binding]; other site 552811001128 Superoxide dismutase [Fe]; Provisional; Region: PTZ00078 552811001129 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 552811001130 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 552811001131 nickel binding site [ion binding]; other site 552811001132 Predicted membrane protein [Function unknown]; Region: COG3462 552811001133 Short C-terminal domain; Region: SHOCT; pfam09851 552811001134 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 552811001135 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 552811001136 GTP binding site; other site 552811001137 Domain of unknown function (DUF362); Region: DUF362; pfam04015 552811001138 Acylphosphatase; Region: Acylphosphatase; pfam00708 552811001139 ribonuclease III; Reviewed; Region: rnc; PRK00102 552811001140 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 552811001141 dimerization interface [polypeptide binding]; other site 552811001142 active site 552811001143 metal binding site [ion binding]; metal-binding site 552811001144 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 552811001145 dsRNA binding site [nucleotide binding]; other site 552811001146 Uncharacterized conserved protein [Function unknown]; Region: COG0432 552811001147 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 552811001148 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 552811001149 Walker A/P-loop; other site 552811001150 ATP binding site [chemical binding]; other site 552811001151 Q-loop/lid; other site 552811001152 ABC transporter signature motif; other site 552811001153 Walker B; other site 552811001154 D-loop; other site 552811001155 H-loop/switch region; other site 552811001156 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 552811001157 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 552811001158 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 552811001159 active site 552811001160 metal binding site [ion binding]; metal-binding site 552811001161 LexA repressor; Validated; Region: PRK00215 552811001162 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 552811001163 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 552811001164 Catalytic site [active] 552811001165 Y-family of DNA polymerases; Region: PolY; cl12025 552811001166 active site 552811001167 DNA binding site [nucleotide binding] 552811001168 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 552811001169 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 552811001170 active site 552811001171 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 552811001172 generic binding surface II; other site 552811001173 generic binding surface I; other site 552811001174 Transposase, Mutator family; Region: Transposase_mut; pfam00872 552811001175 MULE transposase domain; Region: MULE; pfam10551 552811001176 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 552811001177 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 552811001178 CcmE; Region: CcmE; cl00994 552811001179 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 552811001180 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 552811001181 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 552811001182 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 552811001183 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 552811001184 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 552811001185 Walker A/P-loop; other site 552811001186 ATP binding site [chemical binding]; other site 552811001187 Q-loop/lid; other site 552811001188 ABC transporter signature motif; other site 552811001189 Walker B; other site 552811001190 D-loop; other site 552811001191 H-loop/switch region; other site 552811001192 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386 552811001193 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 552811001194 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 552811001195 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 552811001196 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 552811001197 molybdopterin cofactor binding site; other site 552811001198 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 552811001199 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 552811001200 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 552811001201 molybdopterin cofactor binding site; other site 552811001202 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 552811001203 4Fe-4S binding domain; Region: Fer4; cl02805 552811001204 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 552811001205 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 552811001206 Ligand Binding Site [chemical binding]; other site 552811001207 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 552811001208 Transposase; Region: HTH_Tnp_1; pfam01527 552811001209 putative transposase OrfB; Reviewed; Region: PHA02517 552811001210 Integrase core domain; Region: rve; pfam00665 552811001211 Integrase core domain; Region: rve_3; pfam13683 552811001212 putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054 552811001213 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 552811001214 FeS/SAM binding site; other site 552811001215 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 552811001216 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 552811001217 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 552811001218 FeS/SAM binding site; other site 552811001219 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 552811001220 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 552811001221 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 552811001222 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 552811001223 siroheme synthase, N-terminal domain; Region: cysG_Nterm; TIGR01470 552811001224 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 552811001225 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 552811001226 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 552811001227 tRNA; other site 552811001228 putative tRNA binding site [nucleotide binding]; other site 552811001229 putative NADP binding site [chemical binding]; other site 552811001230 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 552811001231 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 552811001232 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 552811001233 domain interfaces; other site 552811001234 active site 552811001235 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 552811001236 active site 552811001237 SAM binding site [chemical binding]; other site 552811001238 homodimer interface [polypeptide binding]; other site 552811001239 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 552811001240 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 552811001241 active site 552811001242 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 552811001243 dimer interface [polypeptide binding]; other site 552811001244 active site 552811001245 Schiff base residues; other site 552811001246 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 552811001247 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 552811001248 inhibitor-cofactor binding pocket; inhibition site 552811001249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 552811001250 catalytic residue [active] 552811001251 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 552811001252 FAD binding site [chemical binding]; other site 552811001253 Recombination protein O N terminal; Region: RecO_N; pfam11967 552811001254 DNA repair protein RecO; Region: reco; TIGR00613 552811001255 Recombination protein O C terminal; Region: RecO_C; pfam02565 552811001256 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 552811001257 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 552811001258 dimer interface [polypeptide binding]; other site 552811001259 putative tRNA-binding site [nucleotide binding]; other site 552811001260 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 552811001261 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 552811001262 oligomer interface [polypeptide binding]; other site 552811001263 metal binding site [ion binding]; metal-binding site 552811001264 metal binding site [ion binding]; metal-binding site 552811001265 Cl binding site [ion binding]; other site 552811001266 aspartate ring; other site 552811001267 basic sphincter; other site 552811001268 putative hydrophobic gate; other site 552811001269 periplasmic entrance; other site 552811001270 recombination protein RecR; Reviewed; Region: recR; PRK00076 552811001271 RecR protein; Region: RecR; pfam02132 552811001272 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 552811001273 putative active site [active] 552811001274 putative metal-binding site [ion binding]; other site 552811001275 tetramer interface [polypeptide binding]; other site 552811001276 hypothetical protein; Validated; Region: PRK00153 552811001277 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 552811001278 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 552811001279 Walker A motif; other site 552811001280 ATP binding site [chemical binding]; other site 552811001281 Walker B motif; other site 552811001282 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 552811001283 arginine finger; other site 552811001284 Transposase, Mutator family; Region: Transposase_mut; pfam00872 552811001285 MULE transposase domain; Region: MULE; pfam10551 552811001286 Dam-replacing family; Region: DRP; pfam06044 552811001287 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 552811001288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552811001289 ATP binding site [chemical binding]; other site 552811001290 Mg2+ binding site [ion binding]; other site 552811001291 G-X-G motif; other site 552811001292 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 552811001293 ATP binding site [chemical binding]; other site 552811001294 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 552811001295 Spc24 subunit of Ndc80; Region: Spc24; pfam08286 552811001296 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 552811001297 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 552811001298 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 552811001299 P loop nucleotide binding; other site 552811001300 switch II; other site 552811001301 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 552811001302 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 552811001303 P loop nucleotide binding; other site 552811001304 switch II; other site 552811001305 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 552811001306 ZIP Zinc transporter; Region: Zip; pfam02535 552811001307 Domain of unknown function DUF59; Region: DUF59; cl00941 552811001308 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 552811001309 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 552811001310 Walker A motif; other site 552811001311 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 552811001312 Transposase, Mutator family; Region: Transposase_mut; pfam00872 552811001313 MULE transposase domain; Region: MULE; pfam10551 552811001314 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 552811001315 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 552811001316 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 552811001317 dimerization interface [polypeptide binding]; other site 552811001318 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 552811001319 dimer interface [polypeptide binding]; other site 552811001320 phosphorylation site [posttranslational modification] 552811001321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552811001322 ATP binding site [chemical binding]; other site 552811001323 Mg2+ binding site [ion binding]; other site 552811001324 G-X-G motif; other site 552811001325 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 552811001326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552811001327 active site 552811001328 phosphorylation site [posttranslational modification] 552811001329 intermolecular recognition site; other site 552811001330 dimerization interface [polypeptide binding]; other site 552811001331 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 552811001332 DNA binding site [nucleotide binding] 552811001333 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 552811001334 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 552811001335 Walker A/P-loop; other site 552811001336 ATP binding site [chemical binding]; other site 552811001337 Q-loop/lid; other site 552811001338 ABC transporter signature motif; other site 552811001339 Walker B; other site 552811001340 D-loop; other site 552811001341 H-loop/switch region; other site 552811001342 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 552811001343 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 552811001344 anthranilate synthase component I; Provisional; Region: PRK13565 552811001345 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 552811001346 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 552811001347 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 552811001348 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 552811001349 glutamine binding [chemical binding]; other site 552811001350 catalytic triad [active] 552811001351 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 552811001352 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 552811001353 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 552811001354 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 552811001355 active site 552811001356 ribulose/triose binding site [chemical binding]; other site 552811001357 phosphate binding site [ion binding]; other site 552811001358 substrate (anthranilate) binding pocket [chemical binding]; other site 552811001359 product (indole) binding pocket [chemical binding]; other site 552811001360 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 552811001361 active site 552811001362 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 552811001363 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 552811001364 pyridoxal 5'-phosphate binding site [chemical binding]; other site 552811001365 catalytic residue [active] 552811001366 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 552811001367 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 552811001368 substrate binding site [chemical binding]; other site 552811001369 active site 552811001370 catalytic residues [active] 552811001371 heterodimer interface [polypeptide binding]; other site 552811001372 PAS fold; Region: PAS_4; pfam08448 552811001373 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 552811001374 putative active site [active] 552811001375 heme pocket [chemical binding]; other site 552811001376 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 552811001377 dimer interface [polypeptide binding]; other site 552811001378 phosphorylation site [posttranslational modification] 552811001379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552811001380 ATP binding site [chemical binding]; other site 552811001381 Mg2+ binding site [ion binding]; other site 552811001382 G-X-G motif; other site 552811001383 Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins; Region: SRPBCC_Aha1; cd08892 552811001384 putative hydrophobic ligand binding site [chemical binding]; other site 552811001385 putative Hsp90 binding residues [polypeptide binding]; other site 552811001386 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 552811001387 active site 552811001388 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 552811001389 active site 552811001390 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 552811001391 catalytic residues [active] 552811001392 Smr domain; Region: Smr; pfam01713 552811001393 BioY family; Region: BioY; pfam02632 552811001394 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 552811001395 homopentamer interface [polypeptide binding]; other site 552811001396 active site 552811001397 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 552811001398 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 552811001399 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 552811001400 dimerization interface [polypeptide binding]; other site 552811001401 active site 552811001402 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 552811001403 Lumazine binding domain; Region: Lum_binding; pfam00677 552811001404 Lumazine binding domain; Region: Lum_binding; pfam00677 552811001405 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 552811001406 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 552811001407 catalytic motif [active] 552811001408 Zn binding site [ion binding]; other site 552811001409 RibD C-terminal domain; Region: RibD_C; cl17279 552811001410 4Fe-4S binding domain; Region: Fer4; cl02805 552811001411 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 552811001412 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 552811001413 Transposase; Region: DDE_Tnp_ISL3; pfam01610 552811001414 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 552811001415 NusA N-terminal domain; Region: NusA_N; pfam08529 552811001416 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 552811001417 RNA binding site [nucleotide binding]; other site 552811001418 homodimer interface [polypeptide binding]; other site 552811001419 NusA-like KH domain; Region: KH_5; pfam13184 552811001420 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 552811001421 G-X-X-G motif; other site 552811001422 Protein of unknown function (DUF448); Region: DUF448; pfam04296 552811001423 putative RNA binding cleft [nucleotide binding]; other site 552811001424 translation initiation factor IF-2; Region: IF-2; TIGR00487 552811001425 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 552811001426 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 552811001427 G1 box; other site 552811001428 putative GEF interaction site [polypeptide binding]; other site 552811001429 GTP/Mg2+ binding site [chemical binding]; other site 552811001430 Switch I region; other site 552811001431 G2 box; other site 552811001432 G3 box; other site 552811001433 Switch II region; other site 552811001434 G4 box; other site 552811001435 G5 box; other site 552811001436 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 552811001437 Translation-initiation factor 2; Region: IF-2; pfam11987 552811001438 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 552811001439 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 552811001440 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 552811001441 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 552811001442 RNA binding site [nucleotide binding]; other site 552811001443 active site 552811001444 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 552811001445 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 552811001446 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 552811001447 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 552811001448 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 552811001449 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 552811001450 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 552811001451 GDP-binding site [chemical binding]; other site 552811001452 ACT binding site; other site 552811001453 IMP binding site; other site 552811001454 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 552811001455 Coenzyme A binding pocket [chemical binding]; other site 552811001456 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 552811001457 dihydrodipicolinate synthase; Region: dapA; TIGR00674 552811001458 dimer interface [polypeptide binding]; other site 552811001459 active site 552811001460 catalytic residue [active] 552811001461 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 552811001462 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 552811001463 dihydrodipicolinate reductase; Provisional; Region: PRK00048 552811001464 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 552811001465 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 552811001466 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 552811001467 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 552811001468 RNase E interface [polypeptide binding]; other site 552811001469 trimer interface [polypeptide binding]; other site 552811001470 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 552811001471 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 552811001472 RNase E interface [polypeptide binding]; other site 552811001473 trimer interface [polypeptide binding]; other site 552811001474 active site 552811001475 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 552811001476 putative nucleic acid binding region [nucleotide binding]; other site 552811001477 G-X-X-G motif; other site 552811001478 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 552811001479 RNA binding site [nucleotide binding]; other site 552811001480 domain interface; other site 552811001481 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 552811001482 16S/18S rRNA binding site [nucleotide binding]; other site 552811001483 S13e-L30e interaction site [polypeptide binding]; other site 552811001484 25S rRNA binding site [nucleotide binding]; other site 552811001485 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 552811001486 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 552811001487 active site 552811001488 catalytic site [active] 552811001489 substrate binding site [chemical binding]; other site 552811001490 PAC2 family; Region: PAC2; pfam09754 552811001491 PAC2 family; Region: PAC2; cl00847 552811001492 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 552811001493 dinuclear metal binding motif [ion binding]; other site 552811001494 Transposase, Mutator family; Region: Transposase_mut; pfam00872 552811001495 MULE transposase domain; Region: MULE; pfam10551 552811001496 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 552811001497 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 552811001498 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 552811001499 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 552811001500 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 552811001501 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 552811001502 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 552811001503 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 552811001504 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 552811001505 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 552811001506 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 552811001507 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 552811001508 beta subunit interaction interface [polypeptide binding]; other site 552811001509 Walker A motif; other site 552811001510 ATP binding site [chemical binding]; other site 552811001511 Walker B motif; other site 552811001512 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 552811001513 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 552811001514 core domain interface [polypeptide binding]; other site 552811001515 delta subunit interface [polypeptide binding]; other site 552811001516 epsilon subunit interface [polypeptide binding]; other site 552811001517 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 552811001518 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 552811001519 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 552811001520 alpha subunit interaction interface [polypeptide binding]; other site 552811001521 Walker A motif; other site 552811001522 ATP binding site [chemical binding]; other site 552811001523 Walker B motif; other site 552811001524 inhibitor binding site; inhibition site 552811001525 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 552811001526 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446 552811001527 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 552811001528 gamma subunit interface [polypeptide binding]; other site 552811001529 epsilon subunit interface [polypeptide binding]; other site 552811001530 LBP interface [polypeptide binding]; other site 552811001531 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 552811001532 KH domain; Region: KH_4; pfam13083 552811001533 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 552811001534 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 552811001535 Active_site [active] 552811001536 peptide chain release factor 2; Provisional; Region: PRK05589 552811001537 PCRF domain; Region: PCRF; pfam03462 552811001538 RF-1 domain; Region: RF-1; pfam00472 552811001539 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 552811001540 Zn binding site [ion binding]; other site 552811001541 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 552811001542 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 552811001543 peptide binding site [polypeptide binding]; other site 552811001544 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 552811001545 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 552811001546 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 552811001547 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 552811001548 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 552811001549 MOFRL family; Region: MOFRL; pfam05161 552811001550 Isochorismatase family; Region: Isochorismatase; pfam00857 552811001551 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 552811001552 catalytic triad [active] 552811001553 dimer interface [polypeptide binding]; other site 552811001554 conserved cis-peptide bond; other site 552811001555 metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921 552811001556 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 552811001557 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 552811001558 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 552811001559 Ligand Binding Site [chemical binding]; other site 552811001560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 552811001561 metabolite-proton symporter; Region: 2A0106; TIGR00883 552811001562 putative substrate translocation pore; other site 552811001563 EamA-like transporter family; Region: EamA; pfam00892 552811001564 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 552811001565 EamA-like transporter family; Region: EamA; pfam00892 552811001566 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 552811001567 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 552811001568 Walker A/P-loop; other site 552811001569 ATP binding site [chemical binding]; other site 552811001570 Q-loop/lid; other site 552811001571 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 552811001572 ABC transporter signature motif; other site 552811001573 Walker B; other site 552811001574 D-loop; other site 552811001575 H-loop/switch region; other site 552811001576 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 552811001577 putative catalytic site [active] 552811001578 putative metal binding site [ion binding]; other site 552811001579 putative phosphate binding site [ion binding]; other site 552811001580 RNase_H superfamily; Region: RNase_H_2; pfam13482 552811001581 active site 552811001582 catalytic site [active] 552811001583 substrate binding site [chemical binding]; other site 552811001584 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 552811001585 Cell division protein FtsA; Region: FtsA; smart00842 552811001586 Cell division protein FtsA; Region: FtsA; pfam14450 552811001587 cell division protein FtsZ; Validated; Region: PRK09330 552811001588 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 552811001589 nucleotide binding site [chemical binding]; other site 552811001590 SulA interaction site; other site 552811001591 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 552811001592 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 552811001593 FeS/SAM binding site; other site 552811001594 HemN C-terminal domain; Region: HemN_C; pfam06969 552811001595 GTP-binding protein LepA; Provisional; Region: PRK05433 552811001596 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 552811001597 G1 box; other site 552811001598 putative GEF interaction site [polypeptide binding]; other site 552811001599 GTP/Mg2+ binding site [chemical binding]; other site 552811001600 Switch I region; other site 552811001601 G2 box; other site 552811001602 G3 box; other site 552811001603 Switch II region; other site 552811001604 G4 box; other site 552811001605 G5 box; other site 552811001606 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 552811001607 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 552811001608 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 552811001609 Transposase domain (DUF772); Region: DUF772; pfam05598 552811001610 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 552811001611 DDE superfamily endonuclease; Region: DDE_4; cl17710 552811001612 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 552811001613 active site 552811001614 putative homodimer interface [polypeptide binding]; other site 552811001615 SAM binding site [chemical binding]; other site 552811001616 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 552811001617 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 552811001618 homodimer interface [polypeptide binding]; other site 552811001619 Walker A motif; other site 552811001620 ATP binding site [chemical binding]; other site 552811001621 hydroxycobalamin binding site [chemical binding]; other site 552811001622 Walker B motif; other site 552811001623 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 552811001624 dimer interface [polypeptide binding]; other site 552811001625 substrate binding site [chemical binding]; other site 552811001626 metal binding sites [ion binding]; metal-binding site 552811001627 Glycosyl transferase 4-like; Region: Glyco_trans_4_2; pfam13477 552811001628 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: Arch_glmU; TIGR03992 552811001629 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 552811001630 active site 552811001631 Substrate binding site; other site 552811001632 Mg++ binding site; other site 552811001633 Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636 552811001634 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: Arch_glmU; TIGR03992 552811001635 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 552811001636 active site 552811001637 Substrate binding site; other site 552811001638 Mg++ binding site; other site 552811001639 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 552811001640 putative trimer interface [polypeptide binding]; other site 552811001641 putative CoA binding site [chemical binding]; other site 552811001642 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 552811001643 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 552811001644 glutaminase active site [active] 552811001645 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 552811001646 dimer interface [polypeptide binding]; other site 552811001647 active site 552811001648 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 552811001649 dimer interface [polypeptide binding]; other site 552811001650 active site 552811001651 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 552811001652 Ligand Binding Site [chemical binding]; other site 552811001653 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 552811001654 substrate binding site [chemical binding]; other site 552811001655 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 552811001656 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 552811001657 motif II; other site 552811001658 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 552811001659 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 552811001660 Ligand Binding Site [chemical binding]; other site 552811001661 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 552811001662 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 552811001663 substrate binding site [chemical binding]; other site 552811001664 hexamer interface [polypeptide binding]; other site 552811001665 metal binding site [ion binding]; metal-binding site 552811001666 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 552811001667 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 552811001668 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 552811001669 TPP-binding site [chemical binding]; other site 552811001670 dimer interface [polypeptide binding]; other site 552811001671 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 552811001672 PYR/PP interface [polypeptide binding]; other site 552811001673 dimer interface [polypeptide binding]; other site 552811001674 TPP binding site [chemical binding]; other site 552811001675 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 552811001676 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 552811001677 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552811001678 active site 552811001679 phosphorylation site [posttranslational modification] 552811001680 intermolecular recognition site; other site 552811001681 dimerization interface [polypeptide binding]; other site 552811001682 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 552811001683 Zn2+ binding site [ion binding]; other site 552811001684 Mg2+ binding site [ion binding]; other site 552811001685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552811001686 Response regulator receiver domain; Region: Response_reg; pfam00072 552811001687 active site 552811001688 phosphorylation site [posttranslational modification] 552811001689 intermolecular recognition site; other site 552811001690 dimerization interface [polypeptide binding]; other site 552811001691 glycogen branching enzyme; Provisional; Region: PRK12313 552811001692 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 552811001693 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 552811001694 active site 552811001695 catalytic site [active] 552811001696 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 552811001697 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 552811001698 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 552811001699 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 552811001700 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 552811001701 Ligand binding site; other site 552811001702 Putative Catalytic site; other site 552811001703 DXD motif; other site 552811001704 Predicted membrane protein [Function unknown]; Region: COG2246 552811001705 GtrA-like protein; Region: GtrA; pfam04138 552811001706 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 552811001707 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 552811001708 ligand binding site [chemical binding]; other site 552811001709 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 552811001710 non-specific DNA interactions [nucleotide binding]; other site 552811001711 DNA binding site [nucleotide binding] 552811001712 sequence specific DNA binding site [nucleotide binding]; other site 552811001713 putative cAMP binding site [chemical binding]; other site 552811001714 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 552811001715 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 552811001716 Domain of unknown function DUF20; Region: UPF0118; pfam01594 552811001717 YtxH-like protein; Region: YtxH; pfam12732 552811001718 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 552811001719 active site 552811001720 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 552811001721 Tubulin/FtsZ family, GTPase domain; Region: Tubulin; pfam00091 552811001722 nucleotide binding site [chemical binding]; other site 552811001723 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 552811001724 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 552811001725 FeS/SAM binding site; other site 552811001726 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 552811001727 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 552811001728 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 552811001729 catalytic triad [active] 552811001730 pantoate--beta-alanine ligase; Region: panC; TIGR00018 552811001731 Pantoate-beta-alanine ligase; Region: PanC; cd00560 552811001732 active site 552811001733 ATP-binding site [chemical binding]; other site 552811001734 pantoate-binding site; other site 552811001735 HXXH motif; other site 552811001736 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 552811001737 oligomerization interface [polypeptide binding]; other site 552811001738 active site 552811001739 metal binding site [ion binding]; metal-binding site 552811001740 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 552811001741 tetramerization interface [polypeptide binding]; other site 552811001742 active site 552811001743 Rossmann-like domain; Region: Rossmann-like; pfam10727 552811001744 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 552811001745 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 552811001746 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 552811001747 Transposase; Region: DDE_Tnp_ISL3; pfam01610 552811001748 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 552811001749 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 552811001750 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 552811001751 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 552811001752 dimer interface [polypeptide binding]; other site 552811001753 putative anticodon binding site; other site 552811001754 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 552811001755 motif 1; other site 552811001756 active site 552811001757 motif 2; other site 552811001758 motif 3; other site 552811001759 seryl-tRNA synthetase; Provisional; Region: PRK05431 552811001760 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 552811001761 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 552811001762 dimer interface [polypeptide binding]; other site 552811001763 active site 552811001764 motif 1; other site 552811001765 motif 2; other site 552811001766 motif 3; other site 552811001767 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 552811001768 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 552811001769 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 552811001770 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 552811001771 catalytic loop [active] 552811001772 iron binding site [ion binding]; other site 552811001773 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 552811001774 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 552811001775 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 552811001776 dimer interface [polypeptide binding]; other site 552811001777 [2Fe-2S] cluster binding site [ion binding]; other site 552811001778 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 552811001779 SLBB domain; Region: SLBB; pfam10531 552811001780 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 552811001781 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 552811001782 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 552811001783 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 552811001784 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 552811001785 putative dimer interface [polypeptide binding]; other site 552811001786 [2Fe-2S] cluster binding site [ion binding]; other site 552811001787 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 552811001788 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 552811001789 TPP-binding site [chemical binding]; other site 552811001790 putative dimer interface [polypeptide binding]; other site 552811001791 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 552811001792 pyruvate ferredoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK08367 552811001793 dimer interface [polypeptide binding]; other site 552811001794 PYR/PP interface [polypeptide binding]; other site 552811001795 TPP binding site [chemical binding]; other site 552811001796 substrate binding site [chemical binding]; other site 552811001797 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 552811001798 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit [Energy production and conversion]; Region: COG1144 552811001799 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 552811001800 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 552811001801 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 552811001802 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 552811001803 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 552811001804 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 552811001805 ATP binding site [chemical binding]; other site 552811001806 putative Mg++ binding site [ion binding]; other site 552811001807 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 552811001808 nucleotide binding region [chemical binding]; other site 552811001809 ATP-binding site [chemical binding]; other site 552811001810 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 552811001811 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 552811001812 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 552811001813 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 552811001814 Walker A motif; other site 552811001815 Walker A/P-loop; other site 552811001816 ATP binding site [chemical binding]; other site 552811001817 ATP binding site [chemical binding]; other site 552811001818 Walker B motif; other site 552811001819 arginine finger; other site 552811001820 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 552811001821 Walker A motif; other site 552811001822 ATP binding site [chemical binding]; other site 552811001823 Walker B motif; other site 552811001824 arginine finger; other site 552811001825 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 552811001826 replicative DNA helicase; Region: DnaB; TIGR00665 552811001827 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 552811001828 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 552811001829 Walker A motif; other site 552811001830 ATP binding site [chemical binding]; other site 552811001831 Walker B motif; other site 552811001832 DNA binding loops [nucleotide binding] 552811001833 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 552811001834 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 552811001835 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 552811001836 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 552811001837 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 552811001838 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 552811001839 putative phosphate acyltransferase; Provisional; Region: PRK05331 552811001840 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 552811001841 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 552811001842 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 552811001843 metal binding site [ion binding]; metal-binding site 552811001844 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 552811001845 MPT binding site; other site 552811001846 trimer interface [polypeptide binding]; other site 552811001847 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 552811001848 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 552811001849 dimer interface [polypeptide binding]; other site 552811001850 putative functional site; other site 552811001851 putative MPT binding site; other site 552811001852 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 552811001853 active site 552811001854 catalytic residues [active] 552811001855 metal binding site [ion binding]; metal-binding site 552811001856 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 552811001857 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 552811001858 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 552811001859 catalytic residue [active] 552811001860 Transposase, Mutator family; Region: Transposase_mut; pfam00872 552811001861 MULE transposase domain; Region: MULE; pfam10551 552811001862 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 552811001863 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 552811001864 pyridoxal 5'-phosphate binding site [chemical binding]; other site 552811001865 catalytic residue [active] 552811001866 Uncharacterized conserved protein [Function unknown]; Region: COG4198 552811001867 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 552811001868 Transposase domain (DUF772); Region: DUF772; pfam05598 552811001869 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 552811001870 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 552811001871 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 552811001872 putative active site [active] 552811001873 catalytic residue [active] 552811001874 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 552811001875 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 552811001876 nucleotide binding pocket [chemical binding]; other site 552811001877 K-X-D-G motif; other site 552811001878 catalytic site [active] 552811001879 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 552811001880 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 552811001881 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 552811001882 helix-hairpin-helix signature motif; other site 552811001883 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 552811001884 Dimer interface [polypeptide binding]; other site 552811001885 BRCT sequence motif; other site 552811001886 histidyl-tRNA synthetase; Region: hisS; TIGR00442 552811001887 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 552811001888 dimer interface [polypeptide binding]; other site 552811001889 motif 1; other site 552811001890 active site 552811001891 motif 2; other site 552811001892 motif 3; other site 552811001893 ATP phosphoribosyltransferase; Region: HisG; cl15266 552811001894 ATP phosphoribosyltransferase; Region: HisG; cl15266 552811001895 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 552811001896 histidinol dehydrogenase; Region: hisD; TIGR00069 552811001897 NAD binding site [chemical binding]; other site 552811001898 dimerization interface [polypeptide binding]; other site 552811001899 product binding site; other site 552811001900 substrate binding site [chemical binding]; other site 552811001901 zinc binding site [ion binding]; other site 552811001902 catalytic residues [active] 552811001903 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 552811001904 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 552811001905 pyridoxal 5'-phosphate binding site [chemical binding]; other site 552811001906 homodimer interface [polypeptide binding]; other site 552811001907 catalytic residue [active] 552811001908 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 552811001909 putative active site pocket [active] 552811001910 4-fold oligomerization interface [polypeptide binding]; other site 552811001911 metal binding residues [ion binding]; metal-binding site 552811001912 3-fold/trimer interface [polypeptide binding]; other site 552811001913 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 552811001914 active site 552811001915 ATP binding site [chemical binding]; other site 552811001916 substrate binding site [chemical binding]; other site 552811001917 adenylosuccinate lyase; Provisional; Region: PRK07492 552811001918 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 552811001919 tetramer interface [polypeptide binding]; other site 552811001920 active site 552811001921 AIR carboxylase; Region: AIRC; pfam00731 552811001922 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 552811001923 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 552811001924 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 552811001925 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 552811001926 GMP synthase; Reviewed; Region: guaA; PRK00074 552811001927 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 552811001928 AMP/PPi binding site [chemical binding]; other site 552811001929 candidate oxyanion hole; other site 552811001930 catalytic triad [active] 552811001931 potential glutamine specificity residues [chemical binding]; other site 552811001932 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 552811001933 ATP Binding subdomain [chemical binding]; other site 552811001934 Ligand Binding sites [chemical binding]; other site 552811001935 Dimerization subdomain; other site 552811001936 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 552811001937 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 552811001938 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 552811001939 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 552811001940 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 552811001941 PYR/PP interface [polypeptide binding]; other site 552811001942 dimer interface [polypeptide binding]; other site 552811001943 TPP binding site [chemical binding]; other site 552811001944 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 552811001945 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 552811001946 TPP-binding site [chemical binding]; other site 552811001947 dimer interface [polypeptide binding]; other site 552811001948 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 552811001949 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 552811001950 putative valine binding site [chemical binding]; other site 552811001951 dimer interface [polypeptide binding]; other site 552811001952 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 552811001953 ketol-acid reductoisomerase; Provisional; Region: PRK05479 552811001954 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 552811001955 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 552811001956 2-isopropylmalate synthase; Validated; Region: PRK00915 552811001957 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 552811001958 active site 552811001959 catalytic residues [active] 552811001960 metal binding site [ion binding]; metal-binding site 552811001961 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 552811001962 MgtC family; Region: MgtC; pfam02308 552811001963 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 552811001964 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 552811001965 substrate binding site [chemical binding]; other site 552811001966 ligand binding site [chemical binding]; other site 552811001967 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 552811001968 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 552811001969 substrate binding site [chemical binding]; other site 552811001970 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 552811001971 tartrate dehydrogenase; Region: TTC; TIGR02089 552811001972 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 552811001973 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 552811001974 active site 552811001975 catalytic residues [active] 552811001976 metal binding site [ion binding]; metal-binding site 552811001977 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 552811001978 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 552811001979 dimerization interface [polypeptide binding]; other site 552811001980 active site 552811001981 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 552811001982 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 552811001983 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 552811001984 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 552811001985 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 552811001986 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 552811001987 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 552811001988 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 552811001989 Walker A/P-loop; other site 552811001990 ATP binding site [chemical binding]; other site 552811001991 Q-loop/lid; other site 552811001992 ABC transporter signature motif; other site 552811001993 Walker B; other site 552811001994 D-loop; other site 552811001995 H-loop/switch region; other site 552811001996 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 552811001997 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 552811001998 dimer interface [polypeptide binding]; other site 552811001999 anticodon binding site; other site 552811002000 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 552811002001 homodimer interface [polypeptide binding]; other site 552811002002 motif 1; other site 552811002003 active site 552811002004 motif 2; other site 552811002005 GAD domain; Region: GAD; pfam02938 552811002006 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 552811002007 active site 552811002008 motif 3; other site 552811002009 trigger factor; Region: tig; TIGR00115 552811002010 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 552811002011 Clp protease; Region: CLP_protease; pfam00574 552811002012 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 552811002013 oligomer interface [polypeptide binding]; other site 552811002014 active site residues [active] 552811002015 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 552811002016 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 552811002017 substrate binding site [chemical binding]; other site 552811002018 ATP binding site [chemical binding]; other site 552811002019 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 552811002020 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 552811002021 active site 552811002022 substrate binding site [chemical binding]; other site 552811002023 cosubstrate binding site; other site 552811002024 catalytic site [active] 552811002025 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 552811002026 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 552811002027 active site 552811002028 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 552811002029 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 552811002030 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 552811002031 active site 552811002032 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 552811002033 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 552811002034 active site 552811002035 Int/Topo IB signature motif; other site 552811002036 DNA topoisomerase I; Validated; Region: PRK05582 552811002037 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 552811002038 active site 552811002039 interdomain interaction site; other site 552811002040 putative metal-binding site [ion binding]; other site 552811002041 nucleotide binding site [chemical binding]; other site 552811002042 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 552811002043 domain I; other site 552811002044 DNA binding groove [nucleotide binding] 552811002045 phosphate binding site [ion binding]; other site 552811002046 domain II; other site 552811002047 domain III; other site 552811002048 nucleotide binding site [chemical binding]; other site 552811002049 catalytic site [active] 552811002050 domain IV; other site 552811002051 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 552811002052 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 552811002053 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 552811002054 DNA protecting protein DprA; Region: dprA; TIGR00732 552811002055 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 552811002056 putative DNA binding site [nucleotide binding]; other site 552811002057 putative Zn2+ binding site [ion binding]; other site 552811002058 diaminopimelate decarboxylase; Region: lysA; TIGR01048 552811002059 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 552811002060 active site 552811002061 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 552811002062 substrate binding site [chemical binding]; other site 552811002063 catalytic residues [active] 552811002064 dimer interface [polypeptide binding]; other site 552811002065 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 552811002066 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 552811002067 PSP1 C-terminal conserved region; Region: PSP1; cl00770 552811002068 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 552811002069 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 552811002070 HflX GTPase family; Region: HflX; cd01878 552811002071 G1 box; other site 552811002072 GTP/Mg2+ binding site [chemical binding]; other site 552811002073 Switch I region; other site 552811002074 G2 box; other site 552811002075 G3 box; other site 552811002076 Switch II region; other site 552811002077 G4 box; other site 552811002078 G5 box; other site 552811002079 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 552811002080 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 552811002081 pyridoxal 5'-phosphate binding site [chemical binding]; other site 552811002082 homodimer interface [polypeptide binding]; other site 552811002083 catalytic residue [active] 552811002084 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 552811002085 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 552811002086 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 552811002087 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 552811002088 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 552811002089 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 552811002090 triosephosphate isomerase; Provisional; Region: PRK14565 552811002091 substrate binding site [chemical binding]; other site 552811002092 dimer interface [polypeptide binding]; other site 552811002093 catalytic triad [active] 552811002094 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04135 552811002095 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 552811002096 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 552811002097 Phosphoglycerate kinase; Region: PGK; pfam00162 552811002098 substrate binding site [chemical binding]; other site 552811002099 hinge regions; other site 552811002100 ADP binding site [chemical binding]; other site 552811002101 catalytic site [active] 552811002102 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 552811002103 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 552811002104 TPP-binding site; other site 552811002105 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 552811002106 PYR/PP interface [polypeptide binding]; other site 552811002107 dimer interface [polypeptide binding]; other site 552811002108 TPP binding site [chemical binding]; other site 552811002109 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 552811002110 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 552811002111 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 552811002112 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552811002113 active site 552811002114 phosphorylation site [posttranslational modification] 552811002115 intermolecular recognition site; other site 552811002116 dimerization interface [polypeptide binding]; other site 552811002117 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 552811002118 DNA binding residues [nucleotide binding] 552811002119 dimerization interface [polypeptide binding]; other site 552811002120 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 552811002121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552811002122 ATP binding site [chemical binding]; other site 552811002123 Mg2+ binding site [ion binding]; other site 552811002124 G-X-G motif; other site 552811002125 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 552811002126 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 552811002127 Cysteine-rich domain; Region: CCG; pfam02754 552811002128 Cysteine-rich domain; Region: CCG; pfam02754 552811002129 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 552811002130 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 552811002131 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 552811002132 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 552811002133 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 552811002134 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 552811002135 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 552811002136 catalytic residues [active] 552811002137 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 552811002138 homotrimer interface [polypeptide binding]; other site 552811002139 Walker A motif; other site 552811002140 GTP binding site [chemical binding]; other site 552811002141 Walker B motif; other site 552811002142 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 552811002143 catalytic core [active] 552811002144 cobalamin synthase; Reviewed; Region: cobS; PRK00235 552811002145 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 552811002146 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 552811002147 putative dimer interface [polypeptide binding]; other site 552811002148 active site pocket [active] 552811002149 putative cataytic base [active] 552811002150 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 552811002151 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 552811002152 pyridoxal 5'-phosphate binding site [chemical binding]; other site 552811002153 homodimer interface [polypeptide binding]; other site 552811002154 catalytic residue [active] 552811002155 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 552811002156 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 552811002157 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 552811002158 Walker A/P-loop; other site 552811002159 ATP binding site [chemical binding]; other site 552811002160 Q-loop/lid; other site 552811002161 ABC transporter signature motif; other site 552811002162 Walker B; other site 552811002163 D-loop; other site 552811002164 H-loop/switch region; other site 552811002165 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 552811002166 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 552811002167 ABC-ATPase subunit interface; other site 552811002168 dimer interface [polypeptide binding]; other site 552811002169 putative PBP binding regions; other site 552811002170 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 552811002171 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 552811002172 cobalamin binding residues [chemical binding]; other site 552811002173 putative BtuC binding residues; other site 552811002174 dimer interface [polypeptide binding]; other site 552811002175 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 552811002176 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 552811002177 cobalamin binding residues [chemical binding]; other site 552811002178 putative BtuC binding residues; other site 552811002179 dimer interface [polypeptide binding]; other site 552811002180 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 552811002181 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 552811002182 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 552811002183 active site 552811002184 effector binding site; other site 552811002185 dimer interface [polypeptide binding]; other site 552811002186 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 552811002187 FeS/SAM binding site; other site 552811002188 Radical SAM superfamily; Region: Radical_SAM; pfam04055 552811002189 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 552811002190 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 552811002191 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 552811002192 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 552811002193 catalytic residues [active] 552811002194 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 552811002195 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 552811002196 nickel binding site [ion binding]; other site 552811002197 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 552811002198 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 552811002199 Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941 552811002200 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 552811002201 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 552811002202 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 552811002203 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 552811002204 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 552811002205 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 552811002206 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 552811002207 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 552811002208 Cysteine-rich domain; Region: CCG; pfam02754 552811002209 Cysteine-rich domain; Region: CCG; pfam02754 552811002210 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 552811002211 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 552811002212 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 552811002213 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 552811002214 FeS/SAM binding site; other site 552811002215 Methyltransferase domain; Region: Methyltransf_23; pfam13489 552811002216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 552811002217 S-adenosylmethionine binding site [chemical binding]; other site 552811002218 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 552811002219 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 552811002220 Coenzyme A binding pocket [chemical binding]; other site 552811002221 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 552811002222 Ligand Binding Site [chemical binding]; other site 552811002223 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 552811002224 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 552811002225 Walker A motif; other site 552811002226 ATP binding site [chemical binding]; other site 552811002227 Walker B motif; other site 552811002228 arginine finger; other site 552811002229 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 552811002230 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 552811002231 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 552811002232 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 552811002233 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 552811002234 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 552811002235 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 552811002236 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 552811002237 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 552811002238 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 552811002239 DNA binding site [nucleotide binding] 552811002240 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 552811002241 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 552811002242 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 552811002243 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 552811002244 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 552811002245 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 552811002246 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 552811002247 RPB10 interaction site [polypeptide binding]; other site 552811002248 RPB11 interaction site [polypeptide binding]; other site 552811002249 RPB3 interaction site [polypeptide binding]; other site 552811002250 RPB12 interaction site [polypeptide binding]; other site 552811002251 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 552811002252 RPB1 interaction site [polypeptide binding]; other site 552811002253 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 552811002254 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 552811002255 active site 552811002256 Riboflavin kinase; Region: Flavokinase; pfam01687 552811002257 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 552811002258 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 552811002259 active site 552811002260 HIGH motif; other site 552811002261 dimer interface [polypeptide binding]; other site 552811002262 KMSKS motif; other site 552811002263 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 552811002264 RNA binding surface [nucleotide binding]; other site 552811002265 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 552811002266 homodimer interface [polypeptide binding]; other site 552811002267 pyridoxal 5'-phosphate binding site [chemical binding]; other site 552811002268 catalytic residue [active] 552811002269 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 552811002270 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 552811002271 ligand binding site [chemical binding]; other site 552811002272 NAD binding site [chemical binding]; other site 552811002273 dimerization interface [polypeptide binding]; other site 552811002274 catalytic site [active] 552811002275 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 552811002276 putative L-serine binding site [chemical binding]; other site 552811002277 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 552811002278 predicted active site [active] 552811002279 catalytic triad [active] 552811002280 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 552811002281 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 552811002282 HIGH motif; other site 552811002283 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 552811002284 active site 552811002285 KMSKS motif; other site 552811002286 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 552811002287 tRNA binding surface [nucleotide binding]; other site 552811002288 anticodon binding site; other site 552811002289 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 552811002290 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 552811002291 G-X-X-G motif; other site 552811002292 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 552811002293 RxxxH motif; other site 552811002294 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 552811002295 active site 552811002296 PQQ-like domain; Region: PQQ_2; pfam13360 552811002297 Trp docking motif [polypeptide binding]; other site 552811002298 PQQ-like domain; Region: PQQ_2; pfam13360 552811002299 Haemolytic domain; Region: Haemolytic; pfam01809 552811002300 Ribonuclease P; Region: Ribonuclease_P; cl00457 552811002301 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 552811002302 30S ribosomal protein S18; Provisional; Region: PRK13400 552811002303 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 552811002304 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 552811002305 dimer interface [polypeptide binding]; other site 552811002306 ssDNA binding site [nucleotide binding]; other site 552811002307 tetramer (dimer of dimers) interface [polypeptide binding]; other site 552811002308 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 552811002309 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 552811002310 MutS domain III; Region: MutS_III; pfam05192 552811002311 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 552811002312 Walker A/P-loop; other site 552811002313 ATP binding site [chemical binding]; other site 552811002314 Q-loop/lid; other site 552811002315 ABC transporter signature motif; other site 552811002316 Walker B; other site 552811002317 D-loop; other site 552811002318 H-loop/switch region; other site 552811002319 Smr domain; Region: Smr; pfam01713 552811002320 PAS fold; Region: PAS_4; pfam08448 552811002321 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 552811002322 putative active site [active] 552811002323 heme pocket [chemical binding]; other site 552811002324 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 552811002325 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 552811002326 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 552811002327 putative active site [active] 552811002328 heme pocket [chemical binding]; other site 552811002329 PAS domain S-box; Region: sensory_box; TIGR00229 552811002330 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 552811002331 putative active site [active] 552811002332 heme pocket [chemical binding]; other site 552811002333 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 552811002334 Histidine kinase; Region: HisKA_2; pfam07568 552811002335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552811002336 ATP binding site [chemical binding]; other site 552811002337 Mg2+ binding site [ion binding]; other site 552811002338 G-X-G motif; other site 552811002339 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 552811002340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552811002341 active site 552811002342 phosphorylation site [posttranslational modification] 552811002343 intermolecular recognition site; other site 552811002344 dimerization interface [polypeptide binding]; other site 552811002345 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 552811002346 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 552811002347 G1 box; other site 552811002348 putative GEF interaction site [polypeptide binding]; other site 552811002349 GTP/Mg2+ binding site [chemical binding]; other site 552811002350 Switch I region; other site 552811002351 G2 box; other site 552811002352 G3 box; other site 552811002353 Switch II region; other site 552811002354 G4 box; other site 552811002355 G5 box; other site 552811002356 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 552811002357 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 552811002358 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 552811002359 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 552811002360 S-adenosylmethionine binding site [chemical binding]; other site 552811002361 Maf-like protein; Region: Maf; pfam02545 552811002362 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 552811002363 active site 552811002364 dimer interface [polypeptide binding]; other site 552811002365 NAD synthetase; Provisional; Region: PRK13981 552811002366 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 552811002367 multimer interface [polypeptide binding]; other site 552811002368 active site 552811002369 catalytic triad [active] 552811002370 protein interface 1 [polypeptide binding]; other site 552811002371 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 552811002372 homodimer interface [polypeptide binding]; other site 552811002373 NAD binding pocket [chemical binding]; other site 552811002374 ATP binding pocket [chemical binding]; other site 552811002375 Mg binding site [ion binding]; other site 552811002376 active-site loop [active] 552811002377 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 552811002378 RNA/DNA hybrid binding site [nucleotide binding]; other site 552811002379 active site 552811002380 hypothetical protein; Reviewed; Region: PRK12497 552811002381 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 552811002382 Thiamine monophosphate synthase/TENI; Region: TMP-TENI; cl17228 552811002383 haloacid dehalogenase superfamily protein; Provisional; Region: PRK14562 552811002384 Translin family; Region: Translin; cl00957 552811002385 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 552811002386 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 552811002387 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 552811002388 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 552811002389 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 552811002390 TrkA-N domain; Region: TrkA_N; pfam02254 552811002391 glycyl-tRNA synthetase; Provisional; Region: PRK04173 552811002392 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 552811002393 dimer interface [polypeptide binding]; other site 552811002394 motif 1; other site 552811002395 active site 552811002396 motif 2; other site 552811002397 motif 3; other site 552811002398 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 552811002399 anticodon binding site; other site 552811002400 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 552811002401 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 552811002402 active site 552811002403 metal binding site [ion binding]; metal-binding site 552811002404 DNA binding site [nucleotide binding] 552811002405 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 552811002406 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 552811002407 RNA binding surface [nucleotide binding]; other site 552811002408 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 552811002409 active site 552811002410 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 552811002411 active site 552811002412 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 552811002413 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 552811002414 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 552811002415 active site 552811002416 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 552811002417 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 552811002418 active site 552811002419 Double zinc ribbon; Region: DZR; pfam12773 552811002420 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 552811002421 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; cl02325 552811002422 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 552811002423 Transposase; Region: HTH_Tnp_1; cl17663 552811002424 putative transposase OrfB; Reviewed; Region: PHA02517 552811002425 Integrase core domain; Region: rve; pfam00665 552811002426 Integrase core domain; Region: rve_3; pfam13683 552811002427 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 552811002428 Transposase; Region: HTH_Tnp_1; pfam01527 552811002429 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 552811002430 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 552811002431 DNA binding residues [nucleotide binding] 552811002432 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 552811002433 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 552811002434 Walker A motif; other site 552811002435 ATP binding site [chemical binding]; other site 552811002436 Walker B motif; other site 552811002437 Bifunctional nuclease; Region: DNase-RNase; pfam02577 552811002438 phosphoenolpyruvate synthase; Validated; Region: PRK06464 552811002439 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 552811002440 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 552811002441 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 552811002442 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 552811002443 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 552811002444 Zn2+ binding site [ion binding]; other site 552811002445 Mg2+ binding site [ion binding]; other site 552811002446 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 552811002447 DNA primase; Validated; Region: dnaG; PRK05667 552811002448 CHC2 zinc finger; Region: zf-CHC2; pfam01807 552811002449 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 552811002450 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 552811002451 active site 552811002452 metal binding site [ion binding]; metal-binding site 552811002453 interdomain interaction site; other site 552811002454 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 552811002455 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 552811002456 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 552811002457 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 552811002458 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 552811002459 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 552811002460 DNA binding residues [nucleotide binding] 552811002461 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 552811002462 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 552811002463 Walker A/P-loop; other site 552811002464 ATP binding site [chemical binding]; other site 552811002465 Q-loop/lid; other site 552811002466 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 552811002467 ABC transporter signature motif; other site 552811002468 Walker B; other site 552811002469 D-loop; other site 552811002470 H-loop/switch region; other site 552811002471 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 552811002472 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 552811002473 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 552811002474 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 552811002475 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 552811002476 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 552811002477 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 552811002478 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 552811002479 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 552811002480 acyl-activating enzyme (AAE) consensus motif; other site 552811002481 active site 552811002482 AMP binding site [chemical binding]; other site 552811002483 CoA binding site [chemical binding]; other site 552811002484 AAA domain; Region: AAA_33; pfam13671 552811002485 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 552811002486 active site 552811002487 multifunctional aminopeptidase A; Provisional; Region: PRK00913 552811002488 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 552811002489 interface (dimer of trimers) [polypeptide binding]; other site 552811002490 Substrate-binding/catalytic site; other site 552811002491 Zn-binding sites [ion binding]; other site 552811002492 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 552811002493 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 552811002494 FeS/SAM binding site; other site 552811002495 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 552811002496 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 552811002497 trimer interface [polypeptide binding]; other site 552811002498 dimer interface [polypeptide binding]; other site 552811002499 putative active site [active] 552811002500 MOSC domain; Region: MOSC; pfam03473 552811002501 glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PRK04207 552811002502 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 552811002503 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 552811002504 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 552811002505 active site 552811002506 Protein of unknown function DUF262; Region: DUF262; pfam03235 552811002507 Uncharacterized conserved protein [Function unknown]; Region: COG1479 552811002508 CHAT domain; Region: CHAT; cl17868 552811002509 Predicted transcriptional regulator [Transcription]; Region: COG1497 552811002510 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 552811002511 putative DNA binding site [nucleotide binding]; other site 552811002512 putative Zn2+ binding site [ion binding]; other site 552811002513 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 552811002514 Formyltetrahydrofolate synthetase [Nucleotide transport and metabolism]; Region: MIS1; COG2759 552811002515 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 552811002516 Potassium binding sites [ion binding]; other site 552811002517 Cesium cation binding sites [ion binding]; other site 552811002518 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 552811002519 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 552811002520 catalytic loop [active] 552811002521 iron binding site [ion binding]; other site 552811002522 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 552811002523 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 552811002524 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 552811002525 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 552811002526 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 552811002527 homodimer interface [polypeptide binding]; other site 552811002528 NADP binding site [chemical binding]; other site 552811002529 substrate binding site [chemical binding]; other site 552811002530 acetyl-CoA decarbonylase/synthase complex subunit delta; Provisional; Region: PRK04452 552811002531 bifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta; Reviewed; Region: PRK09529 552811002532 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 552811002533 metal cluster binding site [ion binding]; other site 552811002534 CO dehydrogenase/acetyl-CoA synthase complex beta subunit; Region: CdhC; pfam03598 552811002535 acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional; Region: PRK04165 552811002536 Putative Fe-S cluster; Region: FeS; pfam04060 552811002537 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 552811002538 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 552811002539 substrate binding pocket [chemical binding]; other site 552811002540 dimer interface [polypeptide binding]; other site 552811002541 inhibitor binding site; inhibition site 552811002542 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 552811002543 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 552811002544 23S rRNA binding site [nucleotide binding]; other site 552811002545 L21 binding site [polypeptide binding]; other site 552811002546 L13 binding site [polypeptide binding]; other site 552811002547 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 552811002548 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 552811002549 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 552811002550 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 552811002551 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 552811002552 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 552811002553 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 552811002554 active site 552811002555 dimer interface [polypeptide binding]; other site 552811002556 motif 1; other site 552811002557 motif 2; other site 552811002558 motif 3; other site 552811002559 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 552811002560 anticodon binding site; other site 552811002561 MAEBL; Provisional; Region: PTZ00121 552811002562 Ferredoxin [Energy production and conversion]; Region: COG1146 552811002563 4Fe-4S binding domain; Region: Fer4_6; pfam12837 552811002564 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 552811002565 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 552811002566 ligand binding site [chemical binding]; other site 552811002567 flexible hinge region; other site 552811002568 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 552811002569 putative switch regulator; other site 552811002570 non-specific DNA interactions [nucleotide binding]; other site 552811002571 DNA binding site [nucleotide binding] 552811002572 sequence specific DNA binding site [nucleotide binding]; other site 552811002573 putative cAMP binding site [chemical binding]; other site 552811002574 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 552811002575 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 552811002576 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 552811002577 nucleotide binding site [chemical binding]; other site 552811002578 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 552811002579 NADH dehydrogenase subunit B; Validated; Region: PRK06411 552811002580 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 552811002581 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 552811002582 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 552811002583 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 552811002584 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 552811002585 4Fe-4S binding domain; Region: Fer4; pfam00037 552811002586 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 552811002587 4Fe-4S binding domain; Region: Fer4; pfam00037 552811002588 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 552811002589 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 552811002590 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 552811002591 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 552811002592 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 552811002593 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 552811002594 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 552811002595 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 552811002596 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 552811002597 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 552811002598 active site 552811002599 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 552811002600 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 552811002601 minor groove reading motif; other site 552811002602 helix-hairpin-helix signature motif; other site 552811002603 substrate binding pocket [chemical binding]; other site 552811002604 active site 552811002605 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 552811002606 cobyric acid synthase; Provisional; Region: PRK00784 552811002607 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 552811002608 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 552811002609 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 552811002610 catalytic triad [active] 552811002611 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 552811002612 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 552811002613 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 552811002614 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 552811002615 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 552811002616 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 552811002617 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 552811002618 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 552811002619 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 552811002620 reductive dehalogenase; Region: RDH; TIGR02486 552811002621 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 552811002622 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 552811002623 twin arginine translocase protein A; Provisional; Region: tatA; PRK00191 552811002624 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 552811002625 methionine sulfoxide reductase A; Provisional; Region: PRK14054 552811002626 Domain of unknown function (DUF427); Region: DUF427; pfam04248 552811002627 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 552811002628 active site 552811002629 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 552811002630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552811002631 active site 552811002632 phosphorylation site [posttranslational modification] 552811002633 intermolecular recognition site; other site 552811002634 dimerization interface [polypeptide binding]; other site 552811002635 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 552811002636 DNA binding residues [nucleotide binding] 552811002637 dimerization interface [polypeptide binding]; other site 552811002638 EamA-like transporter family; Region: EamA; pfam00892 552811002639 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 552811002640 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 552811002641 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 552811002642 enolase; Provisional; Region: eno; PRK00077 552811002643 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 552811002644 dimer interface [polypeptide binding]; other site 552811002645 metal binding site [ion binding]; metal-binding site 552811002646 substrate binding pocket [chemical binding]; other site 552811002647 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 552811002648 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 552811002649 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 552811002650 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 552811002651 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 552811002652 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 552811002653 Tubulin/FtsZ family, GTPase domain; Region: Tubulin; pfam00091 552811002654 nucleotide binding site [chemical binding]; other site 552811002655 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 552811002656 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 552811002657 dimer interface [polypeptide binding]; other site 552811002658 phosphorylation site [posttranslational modification] 552811002659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552811002660 ATP binding site [chemical binding]; other site 552811002661 Mg2+ binding site [ion binding]; other site 552811002662 G-X-G motif; other site 552811002663 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 552811002664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552811002665 active site 552811002666 phosphorylation site [posttranslational modification] 552811002667 intermolecular recognition site; other site 552811002668 dimerization interface [polypeptide binding]; other site 552811002669 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 552811002670 DNA binding site [nucleotide binding] 552811002671 Sm and related proteins; Region: Sm_like; cl00259 552811002672 heptamer interface [polypeptide binding]; other site 552811002673 Sm2 motif; other site 552811002674 hexamer interface [polypeptide binding]; other site 552811002675 RNA binding site [nucleotide binding]; other site 552811002676 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 552811002677 Peptidase family M50; Region: Peptidase_M50; pfam02163 552811002678 active site 552811002679 putative substrate binding region [chemical binding]; other site 552811002680 FOG: CBS domain [General function prediction only]; Region: COG0517 552811002681 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 552811002682 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 552811002683 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 552811002684 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 552811002685 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 552811002686 Peptidase family M50; Region: Peptidase_M50; pfam02163 552811002687 active site 552811002688 putative substrate binding region [chemical binding]; other site 552811002689 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 552811002690 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 552811002691 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 552811002692 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 552811002693 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 552811002694 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 552811002695 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 552811002696 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 552811002697 Walker A motif; other site 552811002698 Walker A/P-loop; other site 552811002699 ATP binding site [chemical binding]; other site 552811002700 ATP binding site [chemical binding]; other site 552811002701 Walker B motif; other site 552811002702 R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich...; Region: R3H; cl00297 552811002703 RxxxH motif; other site 552811002704 thymidylate kinase; Validated; Region: tmk; PRK00698 552811002705 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 552811002706 TMP-binding site; other site 552811002707 ATP-binding site [chemical binding]; other site 552811002708 Bacterial Ig-like domain; Region: Big_5; pfam13205 552811002709 Family description; Region: VCBS; pfam13517 552811002710 Family description; Region: VCBS; pfam13517 552811002711 Family description; Region: VCBS; pfam13517 552811002712 Family description; Region: VCBS; pfam13517 552811002713 Family description; Region: VCBS; pfam13517 552811002714 Family description; Region: VCBS; pfam13517 552811002715 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 552811002716 Immunoglobulin I-set domain; Region: I-set; pfam07679 552811002717 Immunoglobulin domain; Region: Ig; cl11960 552811002718 Immunoglobulin domain; Region: Ig; cl11960 552811002719 Immunoglobulin I-set domain; Region: I-set; pfam07679 552811002720 bifunctional mannosyl-3-phosphoglycerate synthase/mannosyl-3 phosphoglycerate phosphatase; Provisional; Region: PRK14502 552811002721 mannosyl-3-phosphoglycerate synthase; Provisional; Region: PRK14503; cl12225 552811002722 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 552811002723 active site 552811002724 motif I; other site 552811002725 motif II; other site 552811002726 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 552811002727 Nitrogen regulatory protein P-II; Region: P-II; smart00938 552811002728 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 552811002729 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 552811002730 elongation factor P; Validated; Region: PRK00529 552811002731 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 552811002732 RNA binding site [nucleotide binding]; other site 552811002733 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 552811002734 RNA binding site [nucleotide binding]; other site 552811002735 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 552811002736 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 552811002737 motif 1; other site 552811002738 dimer interface [polypeptide binding]; other site 552811002739 active site 552811002740 motif 2; other site 552811002741 motif 3; other site 552811002742 Predicted amidohydrolase [General function prediction only]; Region: COG0388 552811002743 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 552811002744 active site 552811002745 catalytic triad [active] 552811002746 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 552811002747 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 552811002748 FMN binding site [chemical binding]; other site 552811002749 substrate binding site [chemical binding]; other site 552811002750 putative catalytic residue [active] 552811002751 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 552811002752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552811002753 active site 552811002754 phosphorylation site [posttranslational modification] 552811002755 intermolecular recognition site; other site 552811002756 dimerization interface [polypeptide binding]; other site 552811002757 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 552811002758 DNA binding site [nucleotide binding] 552811002759 PAS domain S-box; Region: sensory_box; TIGR00229 552811002760 PAS domain S-box; Region: sensory_box; TIGR00229 552811002761 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 552811002762 putative active site [active] 552811002763 heme pocket [chemical binding]; other site 552811002764 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 552811002765 PAS domain; Region: PAS; smart00091 552811002766 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 552811002767 dimer interface [polypeptide binding]; other site 552811002768 phosphorylation site [posttranslational modification] 552811002769 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552811002770 ATP binding site [chemical binding]; other site 552811002771 Mg2+ binding site [ion binding]; other site 552811002772 G-X-G motif; other site 552811002773 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 552811002774 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 552811002775 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 552811002776 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 552811002777 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 552811002778 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 552811002779 FAD binding pocket [chemical binding]; other site 552811002780 conserved FAD binding motif [chemical binding]; other site 552811002781 phosphate binding motif [ion binding]; other site 552811002782 beta-alpha-beta structure motif; other site 552811002783 NAD binding pocket [chemical binding]; other site 552811002784 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 552811002785 Domain interface; other site 552811002786 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 552811002787 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 552811002788 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 552811002789 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 552811002790 Glucose dehydrogenase; Region: glucose_DH; cd08230 552811002791 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 552811002792 NADP binding site [chemical binding]; other site 552811002793 catalytic Zn binding site [ion binding]; other site 552811002794 structural Zn binding site [ion binding]; other site 552811002795 dimer interface [polypeptide binding]; other site 552811002796 Endonuclease related to archaeal Holliday junction resolvase; Region: Endonuc_Holl; pfam10107 552811002797 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 552811002798 active site 552811002799 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 552811002800 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 552811002801 Catalytic site [active] 552811002802 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 552811002803 Double zinc ribbon; Region: DZR; pfam12773 552811002804 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 552811002805 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 552811002806 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 552811002807 protein binding site [polypeptide binding]; other site 552811002808 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 552811002809 GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441 552811002810 GIY-YIG motif/motif A; other site 552811002811 putative active site [active] 552811002812 putative metal binding site [ion binding]; other site 552811002813 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 552811002814 Uncharacterized conserved protein [Function unknown]; Region: COG2968 552811002815 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 552811002816 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 552811002817 Part of AAA domain; Region: AAA_19; pfam13245 552811002818 Family description; Region: UvrD_C_2; pfam13538 552811002819 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 552811002820 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 552811002821 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 552811002822 FeS/SAM binding site; other site 552811002823 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 552811002824 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 552811002825 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 552811002826 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 552811002827 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 552811002828 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 552811002829 Walker A motif; other site 552811002830 ATP binding site [chemical binding]; other site 552811002831 Walker B motif; other site 552811002832 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 552811002833 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 552811002834 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 552811002835 Walker A/P-loop; other site 552811002836 ATP binding site [chemical binding]; other site 552811002837 Q-loop/lid; other site 552811002838 ABC transporter signature motif; other site 552811002839 Walker B; other site 552811002840 D-loop; other site 552811002841 H-loop/switch region; other site 552811002842 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 552811002843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552811002844 dimer interface [polypeptide binding]; other site 552811002845 conserved gate region; other site 552811002846 ABC-ATPase subunit interface; other site 552811002847 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 552811002848 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 552811002849 reductive dehalogenase; Region: RDH; TIGR02486 552811002850 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 552811002851 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 552811002852 active site 552811002853 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 552811002854 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 552811002855 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 552811002856 dihydroorotase; Validated; Region: pyrC; PRK09357 552811002857 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 552811002858 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 552811002859 active site 552811002860 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 552811002861 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 552811002862 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 552811002863 catalytic site [active] 552811002864 subunit interface [polypeptide binding]; other site 552811002865 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 552811002866 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 552811002867 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 552811002868 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 552811002869 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 552811002870 ATP-grasp domain; Region: ATP-grasp_4; cl17255 552811002871 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 552811002872 IMP binding site; other site 552811002873 dimer interface [polypeptide binding]; other site 552811002874 interdomain contacts; other site 552811002875 partial ornithine binding site; other site 552811002876 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 552811002877 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 552811002878 FAD binding pocket [chemical binding]; other site 552811002879 FAD binding motif [chemical binding]; other site 552811002880 phosphate binding motif [ion binding]; other site 552811002881 beta-alpha-beta structure motif; other site 552811002882 NAD binding pocket [chemical binding]; other site 552811002883 Iron coordination center [ion binding]; other site 552811002884 flavoprotein, HI0933 family; Region: TIGR00275 552811002885 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 552811002886 6-phosphofructokinase; Provisional; Region: PRK03202 552811002887 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 552811002888 active site 552811002889 ADP/pyrophosphate binding site [chemical binding]; other site 552811002890 dimerization interface [polypeptide binding]; other site 552811002891 allosteric effector site; other site 552811002892 fructose-1,6-bisphosphate binding site; other site 552811002893 alanine dehydrogenase; Validated; Region: PRK06046 552811002894 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 552811002895 PAS domain S-box; Region: sensory_box; TIGR00229 552811002896 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 552811002897 putative active site [active] 552811002898 heme pocket [chemical binding]; other site 552811002899 PAS domain S-box; Region: sensory_box; TIGR00229 552811002900 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 552811002901 putative active site [active] 552811002902 heme pocket [chemical binding]; other site 552811002903 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 552811002904 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 552811002905 dimer interface [polypeptide binding]; other site 552811002906 phosphorylation site [posttranslational modification] 552811002907 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552811002908 ATP binding site [chemical binding]; other site 552811002909 Mg2+ binding site [ion binding]; other site 552811002910 G-X-G motif; other site 552811002911 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 552811002912 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552811002913 active site 552811002914 phosphorylation site [posttranslational modification] 552811002915 intermolecular recognition site; other site 552811002916 dimerization interface [polypeptide binding]; other site 552811002917 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 552811002918 DNA binding site [nucleotide binding] 552811002919 GAF domain; Region: GAF; cl17456 552811002920 PAS fold; Region: PAS_4; pfam08448 552811002921 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 552811002922 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 552811002923 putative active site [active] 552811002924 heme pocket [chemical binding]; other site 552811002925 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 552811002926 dimer interface [polypeptide binding]; other site 552811002927 phosphorylation site [posttranslational modification] 552811002928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552811002929 ATP binding site [chemical binding]; other site 552811002930 Mg2+ binding site [ion binding]; other site 552811002931 G-X-G motif; other site 552811002932 acetylornithine aminotransferase; Provisional; Region: PRK02627 552811002933 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 552811002934 inhibitor-cofactor binding pocket; inhibition site 552811002935 pyridoxal 5'-phosphate binding site [chemical binding]; other site 552811002936 catalytic residue [active] 552811002937 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 552811002938 nucleotide binding site [chemical binding]; other site 552811002939 N-acetyl-L-glutamate binding site [chemical binding]; other site 552811002940 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 552811002941 heterotetramer interface [polypeptide binding]; other site 552811002942 active site pocket [active] 552811002943 cleavage site 552811002944 Response regulator receiver domain; Region: Response_reg; pfam00072 552811002945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552811002946 active site 552811002947 phosphorylation site [posttranslational modification] 552811002948 intermolecular recognition site; other site 552811002949 dimerization interface [polypeptide binding]; other site 552811002950 sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910 552811002951 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 552811002952 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 552811002953 FAD binding pocket [chemical binding]; other site 552811002954 FAD binding motif [chemical binding]; other site 552811002955 phosphate binding motif [ion binding]; other site 552811002956 beta-alpha-beta structure motif; other site 552811002957 NAD binding pocket [chemical binding]; other site 552811002958 Iron coordination center [ion binding]; other site 552811002959 Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941 552811002960 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 552811002961 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 552811002962 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 552811002963 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 552811002964 Ligand Binding Site [chemical binding]; other site 552811002965 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 552811002966 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 552811002967 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 552811002968 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 552811002969 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 552811002970 motif II; other site 552811002971 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 552811002972 argininosuccinate synthase; Provisional; Region: PRK13820 552811002973 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 552811002974 ANP binding site [chemical binding]; other site 552811002975 Substrate Binding Site II [chemical binding]; other site 552811002976 Substrate Binding Site I [chemical binding]; other site 552811002977 argininosuccinate lyase; Provisional; Region: PRK00855 552811002978 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 552811002979 active sites [active] 552811002980 tetramer interface [polypeptide binding]; other site 552811002981 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 552811002982 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 552811002983 DAK2 domain; Region: Dak2; pfam02734 552811002984 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 552811002985 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 552811002986 generic binding surface II; other site 552811002987 ssDNA binding site; other site 552811002988 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 552811002989 ATP binding site [chemical binding]; other site 552811002990 putative Mg++ binding site [ion binding]; other site 552811002991 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 552811002992 nucleotide binding region [chemical binding]; other site 552811002993 ATP-binding site [chemical binding]; other site 552811002994 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 552811002995 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 552811002996 GIY-YIG motif/motif A; other site 552811002997 active site 552811002998 catalytic site [active] 552811002999 putative DNA binding site [nucleotide binding]; other site 552811003000 metal binding site [ion binding]; metal-binding site 552811003001 UvrB/uvrC motif; Region: UVR; pfam02151 552811003002 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 552811003003 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 552811003004 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 552811003005 active site 552811003006 motif I; other site 552811003007 motif II; other site 552811003008 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 552811003009 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 552811003010 MutS domain I; Region: MutS_I; pfam01624 552811003011 MutS domain II; Region: MutS_II; pfam05188 552811003012 MutS domain III; Region: MutS_III; pfam05192 552811003013 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 552811003014 Walker A/P-loop; other site 552811003015 ATP binding site [chemical binding]; other site 552811003016 Q-loop/lid; other site 552811003017 ABC transporter signature motif; other site 552811003018 Walker B; other site 552811003019 D-loop; other site 552811003020 H-loop/switch region; other site 552811003021 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 552811003022 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 552811003023 FtsX-like permease family; Region: FtsX; pfam02687 552811003024 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 552811003025 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 552811003026 Walker A/P-loop; other site 552811003027 ATP binding site [chemical binding]; other site 552811003028 Q-loop/lid; other site 552811003029 ABC transporter signature motif; other site 552811003030 Walker B; other site 552811003031 D-loop; other site 552811003032 H-loop/switch region; other site 552811003033 ABC-2 type transporter; Region: ABC2_membrane; cl17235 552811003034 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 552811003035 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 552811003036 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 552811003037 Walker A/P-loop; other site 552811003038 ATP binding site [chemical binding]; other site 552811003039 Q-loop/lid; other site 552811003040 ABC transporter signature motif; other site 552811003041 Walker B; other site 552811003042 D-loop; other site 552811003043 H-loop/switch region; other site 552811003044 Predicted transcriptional regulators [Transcription]; Region: COG1695 552811003045 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 552811003046 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 552811003047 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 552811003048 domain interfaces; other site 552811003049 active site 552811003050 DNA polymerase III subunit beta; Validated; Region: PRK05643 552811003051 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 552811003052 putative DNA binding surface [nucleotide binding]; other site 552811003053 dimer interface [polypeptide binding]; other site 552811003054 beta-clamp/clamp loader binding surface; other site 552811003055 beta-clamp/translesion DNA polymerase binding surface; other site 552811003056 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 552811003057 Uncharacterized protein domain (DUF2202); Region: DUF2202; pfam09968 552811003058 dinuclear metal binding motif [ion binding]; other site 552811003059 AAA domain; Region: AAA_30; pfam13604 552811003060 PIF1-like helicase; Region: PIF1; pfam05970 552811003061 Family description; Region: UvrD_C_2; pfam13538 552811003062 Uncharacterized conserved protein [Function unknown]; Region: COG1633 552811003063 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 552811003064 diiron binding motif [ion binding]; other site 552811003065 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 552811003066 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 552811003067 nucleophile elbow; other site 552811003068 glycogen synthase; Provisional; Region: glgA; PRK00654 552811003069 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 552811003070 ADP-binding pocket [chemical binding]; other site 552811003071 homodimer interface [polypeptide binding]; other site 552811003072 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 552811003073 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 552811003074 ligand binding site; other site 552811003075 oligomer interface; other site 552811003076 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 552811003077 dimer interface [polypeptide binding]; other site 552811003078 N-terminal domain interface [polypeptide binding]; other site 552811003079 sulfate 1 binding site; other site 552811003080 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 552811003081 putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing protein protein; Provisional; Region: PRK14494 552811003082 Walker A motif; other site 552811003083 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 552811003084 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 552811003085 homoserine dehydrogenase; Provisional; Region: PRK06349 552811003086 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 552811003087 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 552811003088 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 552811003089 threonine synthase; Reviewed; Region: PRK06721 552811003090 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 552811003091 homodimer interface [polypeptide binding]; other site 552811003092 pyridoxal 5'-phosphate binding site [chemical binding]; other site 552811003093 catalytic residue [active] 552811003094 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 552811003095 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 552811003096 homodecamer interface [polypeptide binding]; other site 552811003097 GTP cyclohydrolase I; Provisional; Region: PLN03044 552811003098 active site 552811003099 putative catalytic site residues [active] 552811003100 zinc binding site [ion binding]; other site 552811003101 GTP-CH-I/GFRP interaction surface; other site 552811003102 peptide chain release factor 1; Validated; Region: prfA; PRK00591 552811003103 This domain is found in peptide chain release factors; Region: PCRF; smart00937 552811003104 RF-1 domain; Region: RF-1; pfam00472 552811003105 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 552811003106 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 552811003107 S-adenosylmethionine binding site [chemical binding]; other site 552811003108 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 552811003109 Ligand binding site [chemical binding]; other site 552811003110 Electron transfer flavoprotein domain; Region: ETF; pfam01012 552811003111 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 552811003112 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 552811003113 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 552811003114 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 552811003115 PBP superfamily domain; Region: PBP_like_2; pfam12849 552811003116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552811003117 dimer interface [polypeptide binding]; other site 552811003118 conserved gate region; other site 552811003119 putative PBP binding loops; other site 552811003120 ABC-ATPase subunit interface; other site 552811003121 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 552811003122 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 552811003123 Walker A/P-loop; other site 552811003124 ATP binding site [chemical binding]; other site 552811003125 Q-loop/lid; other site 552811003126 ABC transporter signature motif; other site 552811003127 Walker B; other site 552811003128 D-loop; other site 552811003129 H-loop/switch region; other site 552811003130 TOBE domain; Region: TOBE; pfam03459 552811003131 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 552811003132 elongation factor G; Reviewed; Region: PRK12740 552811003133 G1 box; other site 552811003134 putative GEF interaction site [polypeptide binding]; other site 552811003135 GTP/Mg2+ binding site [chemical binding]; other site 552811003136 Switch I region; other site 552811003137 G2 box; other site 552811003138 G3 box; other site 552811003139 Switch II region; other site 552811003140 G4 box; other site 552811003141 G5 box; other site 552811003142 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 552811003143 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 552811003144 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 552811003145 Integral membrane protein DUF95; Region: DUF95; pfam01944 552811003146 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 552811003147 FMN binding site [chemical binding]; other site 552811003148 dimer interface [polypeptide binding]; other site 552811003149 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 552811003150 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 552811003151 active site 552811003152 Int/Topo IB signature motif; other site 552811003153 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 552811003154 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 552811003155 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 552811003156 putative active site [active] 552811003157 heme pocket [chemical binding]; other site 552811003158 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 552811003159 dimer interface [polypeptide binding]; other site 552811003160 phosphorylation site [posttranslational modification] 552811003161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552811003162 ATP binding site [chemical binding]; other site 552811003163 Mg2+ binding site [ion binding]; other site 552811003164 G-X-G motif; other site 552811003165 Response regulator receiver domain; Region: Response_reg; pfam00072 552811003166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552811003167 active site 552811003168 phosphorylation site [posttranslational modification] 552811003169 intermolecular recognition site; other site 552811003170 dimerization interface [polypeptide binding]; other site 552811003171 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 552811003172 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 552811003173 dimer interface [polypeptide binding]; other site 552811003174 active site 552811003175 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 552811003176 DHH family; Region: DHH; pfam01368 552811003177 DHHA1 domain; Region: DHHA1; pfam02272 552811003178 membrane protein; Provisional; Region: PRK14414 552811003179 Bacteriophage phi-29 early protein GP16.7; Region: Phi-29_GP16_7; pfam06720 552811003180 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 552811003181 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 552811003182 ATP binding site [chemical binding]; other site 552811003183 putative Mg++ binding site [ion binding]; other site 552811003184 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 552811003185 nucleotide binding region [chemical binding]; other site 552811003186 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 552811003187 Protein of unknown function (DUF503); Region: DUF503; pfam04456 552811003188 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 552811003189 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 552811003190 DNA binding site [nucleotide binding] 552811003191 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 552811003192 domain_subunit interface; other site 552811003193 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 552811003194 4Fe-4S binding domain; Region: Fer4; pfam00037 552811003195 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 552811003196 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 552811003197 active site 552811003198 FMN binding site [chemical binding]; other site 552811003199 substrate binding site [chemical binding]; other site 552811003200 3Fe-4S cluster binding site [ion binding]; other site 552811003201 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 552811003202 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 552811003203 substrate binding site [chemical binding]; other site 552811003204 glutamase interaction surface [polypeptide binding]; other site 552811003205 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 552811003206 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 552811003207 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 552811003208 putative active site [active] 552811003209 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 552811003210 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 552811003211 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 552811003212 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 552811003213 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 552811003214 putative active site [active] 552811003215 oxyanion strand; other site 552811003216 catalytic triad [active] 552811003217 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 552811003218 Predicted membrane protein [Function unknown]; Region: COG1971 552811003219 Domain of unknown function DUF; Region: DUF204; pfam02659 552811003220 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 552811003221 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 552811003222 FeS/SAM binding site; other site 552811003223 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 552811003224 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 552811003225 ATP-grasp domain; Region: ATP-grasp_4; cl17255 552811003226 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 552811003227 ATP-grasp domain; Region: ATP-grasp_4; cl17255 552811003228 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 552811003229 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 552811003230 Coenzyme A binding pocket [chemical binding]; other site 552811003231 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 552811003232 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 552811003233 dimer interface [polypeptide binding]; other site 552811003234 phosphorylation site [posttranslational modification] 552811003235 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552811003236 ATP binding site [chemical binding]; other site 552811003237 Mg2+ binding site [ion binding]; other site 552811003238 G-X-G motif; other site 552811003239 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 552811003240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552811003241 active site 552811003242 phosphorylation site [posttranslational modification] 552811003243 intermolecular recognition site; other site 552811003244 dimerization interface [polypeptide binding]; other site 552811003245 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 552811003246 DNA binding site [nucleotide binding] 552811003247 Predicted amidohydrolase [General function prediction only]; Region: COG0388 552811003248 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 552811003249 active site 552811003250 catalytic triad [active] 552811003251 dimer interface [polypeptide binding]; other site 552811003252 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 552811003253 active site residue [active] 552811003254 acetyl-CoA synthetase; Provisional; Region: PRK00174 552811003255 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 552811003256 active site 552811003257 CoA binding site [chemical binding]; other site 552811003258 acyl-activating enzyme (AAE) consensus motif; other site 552811003259 AMP binding site [chemical binding]; other site 552811003260 acetate binding site [chemical binding]; other site 552811003261 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 552811003262 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 552811003263 active site 552811003264 Substrate binding site; other site 552811003265 Mg++ binding site; other site 552811003266 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 552811003267 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 552811003268 active site 552811003269 dimerization interface [polypeptide binding]; other site 552811003270 Fructose-1,6-bisphosphatase; Region: FBPase_3; pfam01950 552811003271 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 552811003272 homodimer interface [polypeptide binding]; other site 552811003273 Walker A motif; other site 552811003274 ATP binding site [chemical binding]; other site 552811003275 hydroxycobalamin binding site [chemical binding]; other site 552811003276 Walker B motif; other site 552811003277 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 552811003278 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 552811003279 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 552811003280 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 552811003281 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 552811003282 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 552811003283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 552811003284 Walker A motif; other site 552811003285 ATP binding site [chemical binding]; other site 552811003286 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 552811003287 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 552811003288 Na2 binding site [ion binding]; other site 552811003289 putative substrate binding site 1 [chemical binding]; other site 552811003290 Na binding site 1 [ion binding]; other site 552811003291 putative substrate binding site 2 [chemical binding]; other site 552811003292 Uncharacterized conserved protein [Function unknown]; Region: COG2928 552811003293 Transposase, Mutator family; Region: Transposase_mut; pfam00872 552811003294 MULE transposase domain; Region: MULE; pfam10551 552811003295 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 552811003296 rRNA interaction site [nucleotide binding]; other site 552811003297 S8 interaction site; other site 552811003298 putative laminin-1 binding site; other site 552811003299 elongation factor Ts; Reviewed; Region: tsf; PRK12332 552811003300 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 552811003301 Elongation factor TS; Region: EF_TS; pfam00889 552811003302 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 552811003303 putative nucleotide binding site [chemical binding]; other site 552811003304 uridine monophosphate binding site [chemical binding]; other site 552811003305 homohexameric interface [polypeptide binding]; other site 552811003306 ribosome recycling factor; Reviewed; Region: frr; PRK00083 552811003307 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 552811003308 hinge region; other site 552811003309 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 552811003310 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 552811003311 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 552811003312 active site 552811003313 HIGH motif; other site 552811003314 KMSK motif region; other site 552811003315 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 552811003316 tRNA binding surface [nucleotide binding]; other site 552811003317 anticodon binding site; other site 552811003318 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 552811003319 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 552811003320 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 552811003321 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 552811003322 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 552811003323 DNA binding residues [nucleotide binding] 552811003324 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 552811003325 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 552811003326 active site 552811003327 HIGH motif; other site 552811003328 dimer interface [polypeptide binding]; other site 552811003329 KMSKS motif; other site 552811003330 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 552811003331 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 552811003332 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 552811003333 putative active site [active] 552811003334 putative substrate binding site [chemical binding]; other site 552811003335 putative cosubstrate binding site; other site 552811003336 catalytic site [active] 552811003337 hypothetical protein; Validated; Region: PRK07682 552811003338 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 552811003339 pyridoxal 5'-phosphate binding site [chemical binding]; other site 552811003340 homodimer interface [polypeptide binding]; other site 552811003341 catalytic residue [active] 552811003342 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 552811003343 AsnC family; Region: AsnC_trans_reg; pfam01037 552811003344 Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977 552811003345 Rubrerythrin [Energy production and conversion]; Region: COG1592 552811003346 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 552811003347 iron binding site [ion binding]; other site 552811003348 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 552811003349 catalytic residues [active] 552811003350 Thymidylate synthase complementing protein; Region: Thy1; pfam02511 552811003351 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 552811003352 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 552811003353 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 552811003354 active site 552811003355 HIGH motif; other site 552811003356 nucleotide binding site [chemical binding]; other site 552811003357 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 552811003358 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 552811003359 active site 552811003360 KMSKS motif; other site 552811003361 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 552811003362 tRNA binding surface [nucleotide binding]; other site 552811003363 anticodon binding site; other site 552811003364 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 552811003365 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 552811003366 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 552811003367 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 552811003368 Transposase; Region: DEDD_Tnp_IS110; pfam01548 552811003369 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 552811003370 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 552811003371 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 552811003372 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 552811003373 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 552811003374 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 552811003375 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 552811003376 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 552811003377 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 552811003378 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 552811003379 CPxP motif; other site 552811003380 DsrE/DsrF-like family; Region: DrsE; pfam02635 552811003381 Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350 552811003382 Uncharacterized conserved protein [Function unknown]; Region: COG2361 552811003383 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 552811003384 putative Zn2+ binding site [ion binding]; other site 552811003385 putative DNA binding site [nucleotide binding]; other site 552811003386 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 552811003387 active site 552811003388 NTP binding site [chemical binding]; other site 552811003389 metal binding triad [ion binding]; metal-binding site 552811003390 antibiotic binding site [chemical binding]; other site 552811003391 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 552811003392 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 552811003393 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 552811003394 oligomer interface [polypeptide binding]; other site 552811003395 metal binding site [ion binding]; metal-binding site 552811003396 metal binding site [ion binding]; metal-binding site 552811003397 putative Cl binding site [ion binding]; other site 552811003398 aspartate ring; other site 552811003399 hydrophobic gate; other site 552811003400 periplasmic entrance; other site 552811003401 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 552811003402 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 552811003403 excinuclease ABC subunit B; Provisional; Region: PRK05298 552811003404 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 552811003405 ATP binding site [chemical binding]; other site 552811003406 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 552811003407 nucleotide binding region [chemical binding]; other site 552811003408 ATP-binding site [chemical binding]; other site 552811003409 Ultra-violet resistance protein B; Region: UvrB; pfam12344 552811003410 UvrB/uvrC motif; Region: UVR; pfam02151 552811003411 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 552811003412 reductive dehalogenase; Region: RDH; TIGR02486 552811003413 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 552811003414 S-adenosylmethionine binding site [chemical binding]; other site 552811003415 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 552811003416 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 552811003417 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 552811003418 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 552811003419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 552811003420 Predicted kinase [General function prediction only]; Region: COG0645 552811003421 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 552811003422 active site 552811003423 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 552811003424 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 552811003425 homotetramer interface [polypeptide binding]; other site 552811003426 ligand binding site [chemical binding]; other site 552811003427 catalytic site [active] 552811003428 NAD binding site [chemical binding]; other site 552811003429 S-adenosylmethionine synthetase; Validated; Region: PRK05250 552811003430 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 552811003431 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 552811003432 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 552811003433 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 552811003434 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 552811003435 active site 552811003436 substrate binding site [chemical binding]; other site 552811003437 metal binding site [ion binding]; metal-binding site 552811003438 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 552811003439 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_1; cd05017 552811003440 dimer interface [polypeptide binding]; other site 552811003441 active site 552811003442 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 552811003443 dimer interface [polypeptide binding]; other site 552811003444 active site 552811003445 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 552811003446 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 552811003447 23S rRNA interface [nucleotide binding]; other site 552811003448 L3 interface [polypeptide binding]; other site 552811003449 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 552811003450 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 552811003451 dimerization interface 3.5A [polypeptide binding]; other site 552811003452 active site 552811003453 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 552811003454 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 552811003455 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 552811003456 alphaNTD homodimer interface [polypeptide binding]; other site 552811003457 alphaNTD - beta interaction site [polypeptide binding]; other site 552811003458 alphaNTD - beta' interaction site [polypeptide binding]; other site 552811003459 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 552811003460 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 552811003461 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 552811003462 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 552811003463 RNA binding surface [nucleotide binding]; other site 552811003464 30S ribosomal protein S11; Validated; Region: PRK05309 552811003465 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 552811003466 30S ribosomal protein S13; Region: bact_S13; TIGR03631 552811003467 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 552811003468 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 552811003469 rRNA binding site [nucleotide binding]; other site 552811003470 predicted 30S ribosome binding site; other site 552811003471 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 552811003472 active site 552811003473 adenylate kinase; Reviewed; Region: adk; PRK00279 552811003474 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 552811003475 AMP-binding site [chemical binding]; other site 552811003476 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 552811003477 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 552811003478 SecY translocase; Region: SecY; pfam00344 552811003479 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 552811003480 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 552811003481 23S rRNA binding site [nucleotide binding]; other site 552811003482 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 552811003483 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 552811003484 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 552811003485 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 552811003486 5S rRNA interface [nucleotide binding]; other site 552811003487 23S rRNA interface [nucleotide binding]; other site 552811003488 L5 interface [polypeptide binding]; other site 552811003489 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 552811003490 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 552811003491 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 552811003492 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 552811003493 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 552811003494 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 552811003495 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 552811003496 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 552811003497 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 552811003498 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 552811003499 RNA binding site [nucleotide binding]; other site 552811003500 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 552811003501 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 552811003502 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 552811003503 putative translocon interaction site; other site 552811003504 23S rRNA interface [nucleotide binding]; other site 552811003505 signal recognition particle (SRP54) interaction site; other site 552811003506 L23 interface [polypeptide binding]; other site 552811003507 trigger factor interaction site; other site 552811003508 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 552811003509 23S rRNA interface [nucleotide binding]; other site 552811003510 5S rRNA interface [nucleotide binding]; other site 552811003511 putative antibiotic binding site [chemical binding]; other site 552811003512 L25 interface [polypeptide binding]; other site 552811003513 L27 interface [polypeptide binding]; other site 552811003514 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 552811003515 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 552811003516 G-X-X-G motif; other site 552811003517 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 552811003518 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 552811003519 putative translocon binding site; other site 552811003520 protein-rRNA interface [nucleotide binding]; other site 552811003521 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 552811003522 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 552811003523 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 552811003524 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 552811003525 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 552811003526 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 552811003527 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 552811003528 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 552811003529 elongation factor G; Reviewed; Region: PRK12739 552811003530 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 552811003531 G1 box; other site 552811003532 putative GEF interaction site [polypeptide binding]; other site 552811003533 GTP/Mg2+ binding site [chemical binding]; other site 552811003534 Switch I region; other site 552811003535 G2 box; other site 552811003536 G3 box; other site 552811003537 Switch II region; other site 552811003538 G4 box; other site 552811003539 G5 box; other site 552811003540 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 552811003541 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 552811003542 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 552811003543 30S ribosomal protein S7; Validated; Region: PRK05302 552811003544 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 552811003545 S17 interaction site [polypeptide binding]; other site 552811003546 S8 interaction site; other site 552811003547 16S rRNA interaction site [nucleotide binding]; other site 552811003548 streptomycin interaction site [chemical binding]; other site 552811003549 23S rRNA interaction site [nucleotide binding]; other site 552811003550 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 552811003551 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 552811003552 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 552811003553 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 552811003554 DNA binding residues [nucleotide binding] 552811003555 GH3 auxin-responsive promoter; Region: GH3; pfam03321 552811003556 GH3 auxin-responsive promoter; Region: GH3; pfam03321 552811003557 Phospholipid methyltransferase; Region: PEMT; cl17370 552811003558 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 552811003559 Predicted transcriptional regulator [Transcription]; Region: COG3432 552811003560 Transposase, Mutator family; Region: Transposase_mut; pfam00872 552811003561 MULE transposase domain; Region: MULE; pfam10551 552811003562 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 552811003563 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 552811003564 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 552811003565 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 552811003566 metal binding site [ion binding]; metal-binding site 552811003567 active site 552811003568 I-site; other site 552811003569 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 552811003570 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 552811003571 Zn2+ binding site [ion binding]; other site 552811003572 Mg2+ binding site [ion binding]; other site 552811003573 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 552811003574 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 552811003575 dimerization interface [polypeptide binding]; other site 552811003576 active site 552811003577 L-aspartate oxidase; Provisional; Region: PRK06175 552811003578 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 552811003579 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 552811003580 Preprotein translocase subunit; Region: YajC; pfam02699 552811003581 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14336 552811003582 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 552811003583 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 552811003584 FeS/SAM binding site; other site 552811003585 TRAM domain; Region: TRAM; pfam01938 552811003586 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 552811003587 putative cation:proton antiport protein; Provisional; Region: PRK10669 552811003588 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 552811003589 TrkA-N domain; Region: TrkA_N; pfam02254 552811003590 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 552811003591 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 552811003592 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 552811003593 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 552811003594 Walker A motif; other site 552811003595 ATP binding site [chemical binding]; other site 552811003596 Walker B motif; other site 552811003597 arginine finger; other site 552811003598 Peptidase family M41; Region: Peptidase_M41; pfam01434 552811003599 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 552811003600 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 552811003601 AP (apurinic/apyrimidinic) site pocket; other site 552811003602 DNA interaction; other site 552811003603 Metal-binding active site; metal-binding site 552811003604 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 552811003605 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 552811003606 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 552811003607 active site 552811003608 multimer interface [polypeptide binding]; other site 552811003609 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 552811003610 Glycoprotease family; Region: Peptidase_M22; pfam00814 552811003611 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 552811003612 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 552811003613 motif II; other site 552811003614 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 552811003615 thiamine monophosphate kinase; Provisional; Region: PRK05731 552811003616 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 552811003617 ATP binding site [chemical binding]; other site 552811003618 dimerization interface [polypeptide binding]; other site 552811003619 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 552811003620 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 552811003621 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 552811003622 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 552811003623 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 552811003624 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 552811003625 dimer interface [polypeptide binding]; other site 552811003626 active site 552811003627 glycine-pyridoxal phosphate binding site [chemical binding]; other site 552811003628 folate binding site [chemical binding]; other site 552811003629 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 552811003630 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 552811003631 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 552811003632 active site 552811003633 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 552811003634 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 552811003635 B12 binding site [chemical binding]; other site 552811003636 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 552811003637 PAS domain; Region: PAS_9; pfam13426 552811003638 putative active site [active] 552811003639 heme pocket [chemical binding]; other site 552811003640 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 552811003641 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 552811003642 metal binding site [ion binding]; metal-binding site 552811003643 active site 552811003644 I-site; other site 552811003645 PAS domain S-box; Region: sensory_box; TIGR00229 552811003646 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 552811003647 putative active site [active] 552811003648 heme pocket [chemical binding]; other site 552811003649 PAS domain S-box; Region: sensory_box; TIGR00229 552811003650 PAS domain; Region: PAS; smart00091 552811003651 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 552811003652 putative active site [active] 552811003653 heme pocket [chemical binding]; other site 552811003654 PAS domain S-box; Region: sensory_box; TIGR00229 552811003655 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 552811003656 putative active site [active] 552811003657 heme pocket [chemical binding]; other site 552811003658 PAS fold; Region: PAS_4; pfam08448 552811003659 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 552811003660 putative active site [active] 552811003661 heme pocket [chemical binding]; other site 552811003662 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 552811003663 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 552811003664 putative active site [active] 552811003665 heme pocket [chemical binding]; other site 552811003666 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 552811003667 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 552811003668 putative active site [active] 552811003669 heme pocket [chemical binding]; other site 552811003670 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 552811003671 dimer interface [polypeptide binding]; other site 552811003672 phosphorylation site [posttranslational modification] 552811003673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552811003674 ATP binding site [chemical binding]; other site 552811003675 Mg2+ binding site [ion binding]; other site 552811003676 G-X-G motif; other site 552811003677 Response regulator receiver domain; Region: Response_reg; pfam00072 552811003678 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552811003679 active site 552811003680 phosphorylation site [posttranslational modification] 552811003681 intermolecular recognition site; other site 552811003682 dimerization interface [polypeptide binding]; other site 552811003683 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 552811003684 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 552811003685 catalytic residues [active] 552811003686 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 552811003687 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 552811003688 Histidine kinase; Region: HisKA_3; pfam07730 552811003689 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552811003690 ATP binding site [chemical binding]; other site 552811003691 Mg2+ binding site [ion binding]; other site 552811003692 G-X-G motif; other site 552811003693 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 552811003694 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552811003695 active site 552811003696 phosphorylation site [posttranslational modification] 552811003697 intermolecular recognition site; other site 552811003698 dimerization interface [polypeptide binding]; other site 552811003699 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 552811003700 DNA binding residues [nucleotide binding] 552811003701 dimerization interface [polypeptide binding]; other site 552811003702 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14605 552811003703 RuvA N terminal domain; Region: RuvA_N; pfam01330 552811003704 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 552811003705 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 552811003706 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 552811003707 HIGH motif; other site 552811003708 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 552811003709 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 552811003710 active site 552811003711 KMSKS motif; other site 552811003712 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 552811003713 tRNA binding surface [nucleotide binding]; other site 552811003714 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 552811003715 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 552811003716 Flagellin N-methylase; Region: FliB; pfam03692 552811003717 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 552811003718 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 552811003719 active site 552811003720 (T/H)XGH motif; other site 552811003721 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 552811003722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 552811003723 S-adenosylmethionine binding site [chemical binding]; other site 552811003724 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 552811003725 reductive dehalogenase; Region: RDH; TIGR02486 552811003726 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 552811003727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552811003728 active site 552811003729 phosphorylation site [posttranslational modification] 552811003730 intermolecular recognition site; other site 552811003731 dimerization interface [polypeptide binding]; other site 552811003732 DNA binding site [nucleotide binding] 552811003733 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 552811003734 PAS domain S-box; Region: sensory_box; TIGR00229 552811003735 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 552811003736 putative active site [active] 552811003737 heme pocket [chemical binding]; other site 552811003738 PAS domain S-box; Region: sensory_box; TIGR00229 552811003739 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 552811003740 putative active site [active] 552811003741 heme pocket [chemical binding]; other site 552811003742 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 552811003743 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 552811003744 dimer interface [polypeptide binding]; other site 552811003745 phosphorylation site [posttranslational modification] 552811003746 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552811003747 ATP binding site [chemical binding]; other site 552811003748 Mg2+ binding site [ion binding]; other site 552811003749 G-X-G motif; other site 552811003750 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 552811003751 reductive dehalogenase; Region: RDH; TIGR02486 552811003752 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 552811003753 HicB family; Region: HicB; pfam05534 552811003754 Transposase domain (DUF772); Region: DUF772; pfam05598 552811003755 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 552811003756 DDE superfamily endonuclease; Region: DDE_4; cl17710 552811003757 Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651 552811003758 Protein of unknown function DUF262; Region: DUF262; pfam03235 552811003759 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 552811003760 active site 552811003761 DNA repair protein RadA; Provisional; Region: PRK11823 552811003762 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 552811003763 Walker A motif/ATP binding site; other site 552811003764 ATP binding site [chemical binding]; other site 552811003765 Walker B motif; other site 552811003766 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 552811003767 Methyltransferase domain; Region: Methyltransf_31; pfam13847 552811003768 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 552811003769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 552811003770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 552811003771 putative substrate translocation pore; other site 552811003772 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 552811003773 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 552811003774 MarR family; Region: MarR; pfam01047 552811003775 EDD domain protein, DegV family; Region: DegV; TIGR00762 552811003776 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 552811003777 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 552811003778 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 552811003779 ATP binding site [chemical binding]; other site 552811003780 Mg++ binding site [ion binding]; other site 552811003781 motif III; other site 552811003782 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 552811003783 nucleotide binding region [chemical binding]; other site 552811003784 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 552811003785 Domain of unknown function (DUF955); Region: DUF955; cl01076 552811003786 Peptidase family M48; Region: Peptidase_M48; cl12018 552811003787 Double zinc ribbon; Region: DZR; pfam12773 552811003788 LSD1 zinc finger; Region: zf-LSD1; pfam06943 552811003789 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 552811003790 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 552811003791 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 552811003792 Colicin V production protein; Region: Colicin_V; pfam02674 552811003793 4Fe-4S binding domain; Region: Fer4; cl02805 552811003794 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 552811003795 non-specific DNA binding site [nucleotide binding]; other site 552811003796 salt bridge; other site 552811003797 sequence-specific DNA binding site [nucleotide binding]; other site 552811003798 HerA helicase [Replication, recombination, and repair]; Region: COG0433 552811003799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 552811003800 ATP binding site [chemical binding]; other site 552811003801 G-X-G motif; other site 552811003802 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 552811003803 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 552811003804 beta-clamp/clamp loader binding surface; other site 552811003805 beta-clamp/translesion DNA polymerase binding surface; other site 552811003806 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 552811003807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552811003808 active site 552811003809 phosphorylation site [posttranslational modification] 552811003810 intermolecular recognition site; other site 552811003811 dimerization interface [polypeptide binding]; other site 552811003812 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 552811003813 DNA binding site [nucleotide binding] 552811003814 two-component sensor protein; Provisional; Region: cpxA; PRK09470 552811003815 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 552811003816 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 552811003817 dimerization interface [polypeptide binding]; other site 552811003818 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 552811003819 putative active site [active] 552811003820 heme pocket [chemical binding]; other site 552811003821 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 552811003822 dimer interface [polypeptide binding]; other site 552811003823 phosphorylation site [posttranslational modification] 552811003824 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552811003825 ATP binding site [chemical binding]; other site 552811003826 Mg2+ binding site [ion binding]; other site 552811003827 G-X-G motif; other site 552811003828 Transposase, Mutator family; Region: Transposase_mut; pfam00872 552811003829 MULE transposase domain; Region: MULE; pfam10551 552811003830 Rubrerythrin [Energy production and conversion]; Region: COG1592 552811003831 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 552811003832 binuclear metal center [ion binding]; other site 552811003833 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 552811003834 iron binding site [ion binding]; other site 552811003835 Transposase, Mutator family; Region: Transposase_mut; pfam00872 552811003836 MULE transposase domain; Region: MULE; pfam10551 552811003837 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 552811003838 serpin-like protein; Provisional; Region: PHA02660 552811003839 reactive center loop; other site 552811003840 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 552811003841 Clp protease ATP binding subunit; Region: clpC; CHL00095 552811003842 Clp amino terminal domain; Region: Clp_N; pfam02861 552811003843 Clp amino terminal domain; Region: Clp_N; pfam02861 552811003844 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 552811003845 Walker A motif; other site 552811003846 ATP binding site [chemical binding]; other site 552811003847 Walker B motif; other site 552811003848 arginine finger; other site 552811003849 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 552811003850 Walker A motif; other site 552811003851 ATP binding site [chemical binding]; other site 552811003852 Walker B motif; other site 552811003853 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 552811003854 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 552811003855 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 552811003856 putative active site [active] 552811003857 catalytic triad [active] 552811003858 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 552811003859 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 552811003860 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 552811003861 dimerization interface [polypeptide binding]; other site 552811003862 ATP binding site [chemical binding]; other site 552811003863 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 552811003864 dimerization interface [polypeptide binding]; other site 552811003865 ATP binding site [chemical binding]; other site 552811003866 Methyltransferase domain; Region: Methyltransf_23; pfam13489 552811003867 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 552811003868 S-adenosylmethionine binding site [chemical binding]; other site 552811003869 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 552811003870 putative homodimer interface [polypeptide binding]; other site 552811003871 putative homotetramer interface [polypeptide binding]; other site 552811003872 putative allosteric switch controlling residues; other site 552811003873 putative metal binding site [ion binding]; other site 552811003874 putative homodimer-homodimer interface [polypeptide binding]; other site 552811003875 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 552811003876 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 552811003877 metal-binding site [ion binding] 552811003878 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 552811003879 metal-binding site [ion binding] 552811003880 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 552811003881 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 552811003882 metal-binding site [ion binding] 552811003883 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 552811003884 Soluble P-type ATPase [General function prediction only]; Region: COG4087 552811003885 putative oxidoreductase; Provisional; Region: PRK12831 552811003886 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 552811003887 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 552811003888 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 552811003889 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 552811003890 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 552811003891 FAD binding pocket [chemical binding]; other site 552811003892 FAD binding motif [chemical binding]; other site 552811003893 phosphate binding motif [ion binding]; other site 552811003894 beta-alpha-beta structure motif; other site 552811003895 NAD binding pocket [chemical binding]; other site 552811003896 Iron coordination center [ion binding]; other site 552811003897 SnoaL-like domain; Region: SnoaL_4; cl17707 552811003898 SnoaL-like domain; Region: SnoaL_3; pfam13474 552811003899 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 552811003900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 552811003901 MFS/sugar transport protein; Region: MFS_2; pfam13347 552811003902 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 552811003903 trimer interface [polypeptide binding]; other site 552811003904 active site 552811003905 Smr domain; Region: Smr; pfam01713 552811003906 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12858 552811003907 catalytic residue [active] 552811003908 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 552811003909 DNA binding residues [nucleotide binding] 552811003910 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 552811003911 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552811003912 active site 552811003913 phosphorylation site [posttranslational modification] 552811003914 intermolecular recognition site; other site 552811003915 dimerization interface [polypeptide binding]; other site 552811003916 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 552811003917 DNA binding residues [nucleotide binding] 552811003918 dimerization interface [polypeptide binding]; other site 552811003919 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 552811003920 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 552811003921 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 552811003922 Walker A motif; other site 552811003923 ATP binding site [chemical binding]; other site 552811003924 Walker B motif; other site 552811003925 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 552811003926 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 552811003927 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 552811003928 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 552811003929 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 552811003930 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 552811003931 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 552811003932 Walker A motif; other site 552811003933 ATP binding site [chemical binding]; other site 552811003934 Walker B motif; other site 552811003935 hypothetical protein; Provisional; Region: PRK01184 552811003936 hypothetical protein; Provisional; Region: PRK08356 552811003937 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 552811003938 catalytic motif [active] 552811003939 Zn binding site [ion binding]; other site 552811003940 cell division protein MraZ; Reviewed; Region: PRK00326 552811003941 MraZ protein; Region: MraZ; pfam02381 552811003942 MraZ protein; Region: MraZ; pfam02381 552811003943 MraW methylase family; Region: Methyltransf_5; cl17771 552811003944 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 552811003945 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 552811003946 Cell division protein FtsA; Region: FtsA; smart00842 552811003947 Cell division protein FtsA; Region: FtsA; pfam14450 552811003948 cell division protein FtsZ; Validated; Region: PRK09330 552811003949 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 552811003950 nucleotide binding site [chemical binding]; other site 552811003951 SulA interaction site; other site 552811003952 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 552811003953 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 552811003954 putative tRNA-binding site [nucleotide binding]; other site 552811003955 B3/4 domain; Region: B3_4; pfam03483 552811003956 tRNA synthetase B5 domain; Region: B5; pfam03484 552811003957 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 552811003958 dimer interface [polypeptide binding]; other site 552811003959 motif 1; other site 552811003960 motif 3; other site 552811003961 motif 2; other site 552811003962 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 552811003963 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 552811003964 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 552811003965 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 552811003966 dimer interface [polypeptide binding]; other site 552811003967 motif 1; other site 552811003968 active site 552811003969 motif 2; other site 552811003970 motif 3; other site 552811003971 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 552811003972 C-terminal peptidase (prc); Region: prc; TIGR00225 552811003973 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 552811003974 protein binding site [polypeptide binding]; other site 552811003975 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 552811003976 Catalytic dyad [active] 552811003977 EDD domain protein, DegV family; Region: DegV; TIGR00762 552811003978 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 552811003979 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 552811003980 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 552811003981 Walker A/P-loop; other site 552811003982 ATP binding site [chemical binding]; other site 552811003983 Q-loop/lid; other site 552811003984 ABC transporter signature motif; other site 552811003985 Walker B; other site 552811003986 D-loop; other site 552811003987 H-loop/switch region; other site 552811003988 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 552811003989 cobalt transport protein CbiM; Validated; Region: PRK06265 552811003990 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 552811003991 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 552811003992 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 552811003993 putative DNA binding site [nucleotide binding]; other site 552811003994 dimerization interface [polypeptide binding]; other site 552811003995 putative Zn2+ binding site [ion binding]; other site 552811003996 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 552811003997 active site 552811003998 NTP binding site [chemical binding]; other site 552811003999 metal binding triad [ion binding]; metal-binding site 552811004000 antibiotic binding site [chemical binding]; other site 552811004001 Predicted transcriptional regulator [Transcription]; Region: COG2378 552811004002 HTH domain; Region: HTH_11; cl17392 552811004003 WYL domain; Region: WYL; pfam13280 552811004004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 552811004005 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 552811004006 Walker A motif; other site 552811004007 ATP binding site [chemical binding]; other site 552811004008 Walker B motif; other site 552811004009 arginine finger; other site 552811004010 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 552811004011 N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178 552811004012 PLD-like domain; Region: PLDc_2; pfam13091 552811004013 putative homodimer interface [polypeptide binding]; other site 552811004014 putative active site [active] 552811004015 catalytic site [active] 552811004016 DEAD-like helicases superfamily; Region: DEXDc; smart00487 552811004017 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 552811004018 putative Mg++ binding site [ion binding]; other site 552811004019 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 552811004020 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 552811004021 nucleotide binding region [chemical binding]; other site 552811004022 ATP-binding site [chemical binding]; other site 552811004023 Tropomyosin like; Region: Tropomyosin_1; pfam12718 552811004024 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 552811004025 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 552811004026 Transposase domain (DUF772); Region: DUF772; pfam05598 552811004027 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 552811004028 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 552811004029 putative transposase OrfB; Reviewed; Region: PHA02517 552811004030 Integrase core domain; Region: rve; pfam00665 552811004031 Integrase core domain; Region: rve_3; pfam13683 552811004032 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 552811004033 Transposase; Region: HTH_Tnp_1; pfam01527 552811004034 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 552811004035 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 552811004036 DNA binding residues [nucleotide binding] 552811004037 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 552811004038 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 552811004039 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 552811004040 iron-sulfur cluster [ion binding]; other site 552811004041 [2Fe-2S] cluster binding site [ion binding]; other site 552811004042 Predicted methyltransferases [General function prediction only]; Region: COG0313 552811004043 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 552811004044 putative SAM binding site [chemical binding]; other site 552811004045 putative homodimer interface [polypeptide binding]; other site 552811004046 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 552811004047 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 552811004048 active site 552811004049 HIGH motif; other site 552811004050 KMSKS motif; other site 552811004051 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 552811004052 tRNA binding surface [nucleotide binding]; other site 552811004053 anticodon binding site; other site 552811004054 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 552811004055 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 552811004056 substrate binding pocket [chemical binding]; other site 552811004057 chain length determination region; other site 552811004058 substrate-Mg2+ binding site; other site 552811004059 catalytic residues [active] 552811004060 aspartate-rich region 1; other site 552811004061 active site lid residues [active] 552811004062 aspartate-rich region 2; other site 552811004063 Terminase-like family; Region: Terminase_6; pfam03237 552811004064 Short C-terminal domain; Region: SHOCT; pfam09851 552811004065 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 552811004066 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 552811004067 Moco binding site; other site 552811004068 metal coordination site [ion binding]; other site 552811004069 Cytochrome c; Region: Cytochrom_C; pfam00034 552811004070 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 552811004071 GIY-YIG motif/motif A; other site 552811004072 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 552811004073 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 552811004074 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 552811004075 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 552811004076 putative dimer interface [polypeptide binding]; other site 552811004077 sec-independent translocase; Provisional; Region: PRK00708 552811004078 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 552811004079 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 552811004080 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 552811004081 active site 552811004082 dimer interface [polypeptide binding]; other site 552811004083 effector binding site; other site 552811004084 TSCPD domain; Region: TSCPD; pfam12637 552811004085 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 552811004086 ATP cone domain; Region: ATP-cone; pfam03477 552811004087 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 552811004088 Cytochrome c; Region: Cytochrom_C; pfam00034 552811004089 Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941 552811004090 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 552811004091 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 552811004092 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 552811004093 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 552811004094 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 552811004095 putative substrate-binding site; other site 552811004096 nickel binding site [ion binding]; other site 552811004097 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 552811004098 classical (c) SDRs; Region: SDR_c; cd05233 552811004099 NAD(P) binding site [chemical binding]; other site 552811004100 active site 552811004101 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 552811004102 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 552811004103 Walker A/P-loop; other site 552811004104 ATP binding site [chemical binding]; other site 552811004105 Q-loop/lid; other site 552811004106 ABC transporter signature motif; other site 552811004107 Walker B; other site 552811004108 D-loop; other site 552811004109 H-loop/switch region; other site 552811004110 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 552811004111 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 552811004112 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 552811004113 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 552811004114 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 552811004115 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 552811004116 Walker A/P-loop; other site 552811004117 ATP binding site [chemical binding]; other site 552811004118 Q-loop/lid; other site 552811004119 ABC transporter signature motif; other site 552811004120 Walker B; other site 552811004121 D-loop; other site 552811004122 H-loop/switch region; other site 552811004123 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 552811004124 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 552811004125 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 552811004126 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 552811004127 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 552811004128 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 552811004129 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 552811004130 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 552811004131 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 552811004132 HSP70 interaction site [polypeptide binding]; other site 552811004133 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 552811004134 Zn binding sites [ion binding]; other site 552811004135 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 552811004136 dimer interface [polypeptide binding]; other site 552811004137 putative transposase OrfB; Reviewed; Region: PHA02517 552811004138 Integrase core domain; Region: rve; pfam00665 552811004139 Integrase core domain; Region: rve_3; pfam13683 552811004140 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 552811004141 Transposase; Region: HTH_Tnp_1; pfam01527 552811004142 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 552811004143 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 552811004144 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 552811004145 Coenzyme A binding pocket [chemical binding]; other site 552811004146 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 552811004147 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 552811004148 inhibitor-cofactor binding pocket; inhibition site 552811004149 pyridoxal 5'-phosphate binding site [chemical binding]; other site 552811004150 catalytic residue [active] 552811004151 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 552811004152 Response regulator receiver domain; Region: Response_reg; pfam00072 552811004153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552811004154 active site 552811004155 phosphorylation site [posttranslational modification] 552811004156 intermolecular recognition site; other site 552811004157 Rhomboid family; Region: Rhomboid; cl11446 552811004158 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 552811004159 Clp amino terminal domain; Region: Clp_N; pfam02861 552811004160 Clp amino terminal domain; Region: Clp_N; pfam02861 552811004161 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 552811004162 Walker A motif; other site 552811004163 ATP binding site [chemical binding]; other site 552811004164 Walker B motif; other site 552811004165 arginine finger; other site 552811004166 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 552811004167 Walker A motif; other site 552811004168 ATP binding site [chemical binding]; other site 552811004169 Walker B motif; other site 552811004170 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 552811004171 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 552811004172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552811004173 active site 552811004174 phosphorylation site [posttranslational modification] 552811004175 intermolecular recognition site; other site 552811004176 dimerization interface [polypeptide binding]; other site 552811004177 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 552811004178 DNA binding site [nucleotide binding] 552811004179 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 552811004180 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 552811004181 putative active site [active] 552811004182 heme pocket [chemical binding]; other site 552811004183 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 552811004184 dimer interface [polypeptide binding]; other site 552811004185 phosphorylation site [posttranslational modification] 552811004186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552811004187 ATP binding site [chemical binding]; other site 552811004188 Mg2+ binding site [ion binding]; other site 552811004189 G-X-G motif; other site 552811004190 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 552811004191 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 552811004192 tetramer interface [polypeptide binding]; other site 552811004193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 552811004194 catalytic residue [active] 552811004195 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 552811004196 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 552811004197 dimer interface [polypeptide binding]; other site 552811004198 active site 552811004199 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 552811004200 active site 552811004201 dimer interfaces [polypeptide binding]; other site 552811004202 catalytic residues [active] 552811004203 PBP superfamily domain; Region: PBP_like_2; cl17296 552811004204 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 552811004205 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 552811004206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552811004207 dimer interface [polypeptide binding]; other site 552811004208 conserved gate region; other site 552811004209 putative PBP binding loops; other site 552811004210 ABC-ATPase subunit interface; other site 552811004211 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 552811004212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552811004213 dimer interface [polypeptide binding]; other site 552811004214 conserved gate region; other site 552811004215 putative PBP binding loops; other site 552811004216 ABC-ATPase subunit interface; other site 552811004217 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 552811004218 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 552811004219 Walker A/P-loop; other site 552811004220 ATP binding site [chemical binding]; other site 552811004221 Q-loop/lid; other site 552811004222 ABC transporter signature motif; other site 552811004223 Walker B; other site 552811004224 D-loop; other site 552811004225 H-loop/switch region; other site 552811004226 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 552811004227 PhoU domain; Region: PhoU; pfam01895 552811004228 PhoU domain; Region: PhoU; pfam01895 552811004229 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 552811004230 Low molecular weight phosphatase family; Region: LMWPc; cl00105 552811004231 active site 552811004232 Uncharacterized conserved protein [Function unknown]; Region: COG3339 552811004233 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 552811004234 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 552811004235 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 552811004236 putative active site [active] 552811004237 dimerization interface [polypeptide binding]; other site 552811004238 putative tRNAtyr binding site [nucleotide binding]; other site 552811004239 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 552811004240 reductive dehalogenase; Region: RDH; TIGR02486 552811004241 flavoprotein, HI0933 family; Region: TIGR00275 552811004242 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 552811004243 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 552811004244 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 552811004245 active site 552811004246 catalytic residues [active] 552811004247 metal binding site [ion binding]; metal-binding site 552811004248 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 552811004249 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 552811004250 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 552811004251 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 552811004252 FeS/SAM binding site; other site 552811004253 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 552811004254 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 552811004255 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 552811004256 ligand binding site [chemical binding]; other site 552811004257 flexible hinge region; other site 552811004258 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 552811004259 non-specific DNA interactions [nucleotide binding]; other site 552811004260 DNA binding site [nucleotide binding] 552811004261 sequence specific DNA binding site [nucleotide binding]; other site 552811004262 putative cAMP binding site [chemical binding]; other site 552811004263 Domain of unknown function, E. rectale Gene description (DUF3879); Region: DUF3879; pfam12995 552811004264 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 552811004265 GTPase CgtA; Reviewed; Region: obgE; PRK12297 552811004266 GTP1/OBG; Region: GTP1_OBG; pfam01018 552811004267 Obg GTPase; Region: Obg; cd01898 552811004268 G1 box; other site 552811004269 GTP/Mg2+ binding site [chemical binding]; other site 552811004270 Switch I region; other site 552811004271 G2 box; other site 552811004272 G3 box; other site 552811004273 Switch II region; other site 552811004274 G4 box; other site 552811004275 G5 box; other site 552811004276 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 552811004277 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 552811004278 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 552811004279 active site 552811004280 (T/H)XGH motif; other site 552811004281 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 552811004282 putative FMN binding site [chemical binding]; other site 552811004283 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 552811004284 metal binding site 2 [ion binding]; metal-binding site 552811004285 putative DNA binding helix; other site 552811004286 metal binding site 1 [ion binding]; metal-binding site 552811004287 dimer interface [polypeptide binding]; other site 552811004288 structural Zn2+ binding site [ion binding]; other site 552811004289 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 552811004290 phosphodiesterase; Provisional; Region: PRK12704 552811004291 Spore germination protein GerPC; Region: GerPC; pfam10737 552811004292 KH domain; Region: KH_1; pfam00013 552811004293 nucleic acid binding region [nucleotide binding]; other site 552811004294 G-X-X-G motif; other site 552811004295 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 552811004296 Zn2+ binding site [ion binding]; other site 552811004297 Mg2+ binding site [ion binding]; other site 552811004298 RecX family; Region: RecX; pfam02631 552811004299 recombinase A; Provisional; Region: recA; PRK09354 552811004300 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 552811004301 hexamer interface [polypeptide binding]; other site 552811004302 Walker A motif; other site 552811004303 ATP binding site [chemical binding]; other site 552811004304 Walker B motif; other site 552811004305 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 552811004306 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 552811004307 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 552811004308 FMN-binding domain; Region: FMN_bind; cl01081 552811004309 FMN-binding domain; Region: FMN_bind; pfam04205 552811004310 Transposase, Mutator family; Region: Transposase_mut; pfam00872 552811004311 MULE transposase domain; Region: MULE; pfam10551 552811004312 putative transposase OrfB; Reviewed; Region: PHA02517 552811004313 Integrase core domain; Region: rve; pfam00665 552811004314 Integrase core domain; Region: rve_3; pfam13683 552811004315 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 552811004316 Transposase; Region: HTH_Tnp_1; pfam01527 552811004317 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 552811004318 reductive dehalogenase; Region: RDH; TIGR02486 552811004319 FMN-binding domain; Region: FMN_bind; pfam04205 552811004320 4Fe-4S binding domain; Region: Fer4_5; pfam12801 552811004321 4Fe-4S binding domain; Region: Fer4; pfam00037 552811004322 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 552811004323 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 552811004324 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 552811004325 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 552811004326 ApbE family; Region: ApbE; pfam02424 552811004327 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 552811004328 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 552811004329 Zn2+ binding site [ion binding]; other site 552811004330 Mg2+ binding site [ion binding]; other site 552811004331 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 552811004332 synthetase active site [active] 552811004333 NTP binding site [chemical binding]; other site 552811004334 metal binding site [ion binding]; metal-binding site 552811004335 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 552811004336 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 552811004337 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 552811004338 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552811004339 ATP binding site [chemical binding]; other site 552811004340 Mg2+ binding site [ion binding]; other site 552811004341 G-X-G motif; other site 552811004342 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 552811004343 anchoring element; other site 552811004344 dimer interface [polypeptide binding]; other site 552811004345 ATP binding site [chemical binding]; other site 552811004346 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 552811004347 active site 552811004348 putative metal-binding site [ion binding]; other site 552811004349 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 552811004350 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 552811004351 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 552811004352 active site 552811004353 NAD binding site [chemical binding]; other site 552811004354 metal binding site [ion binding]; metal-binding site 552811004355 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 552811004356 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 552811004357 nucleotide binding site [chemical binding]; other site 552811004358 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 552811004359 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 552811004360 active site 552811004361 tetramer interface; other site 552811004362 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 552811004363 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 552811004364 motif 1; other site 552811004365 active site 552811004366 motif 2; other site 552811004367 motif 3; other site 552811004368 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 552811004369 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 552811004370 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 552811004371 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 552811004372 GTP-binding protein YchF; Reviewed; Region: PRK09601 552811004373 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 552811004374 G1 box; other site 552811004375 GTP/Mg2+ binding site [chemical binding]; other site 552811004376 Switch I region; other site 552811004377 G3 box; other site 552811004378 Switch II region; other site 552811004379 G4 box; other site 552811004380 G5 box; other site 552811004381 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 552811004382 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 552811004383 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 552811004384 dimer interface [polypeptide binding]; other site 552811004385 motif 1; other site 552811004386 active site 552811004387 motif 2; other site 552811004388 motif 3; other site 552811004389 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 552811004390 anticodon binding site; other site 552811004391 Tetratricopeptide repeat; Region: TPR_16; pfam13432 552811004392 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 552811004393 binding surface 552811004394 TPR motif; other site 552811004395 DNA gyrase subunit A; Validated; Region: PRK05560 552811004396 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 552811004397 CAP-like domain; other site 552811004398 active site 552811004399 primary dimer interface [polypeptide binding]; other site 552811004400 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 552811004401 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 552811004402 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 552811004403 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 552811004404 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 552811004405 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 552811004406 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 552811004407 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 552811004408 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 552811004409 Catalytic site [active] 552811004410 L-fuculose phosphate aldolase; Provisional; Region: PRK08660 552811004411 intersubunit interface [polypeptide binding]; other site 552811004412 active site 552811004413 Zn2+ binding site [ion binding]; other site 552811004414 Predicted membrane protein [Function unknown]; Region: COG4818 552811004415 Transposase, Mutator family; Region: Transposase_mut; pfam00872 552811004416 MULE transposase domain; Region: MULE; pfam10551 552811004417 Fic family protein [Function unknown]; Region: COG3177 552811004418 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 552811004419 Fic/DOC family; Region: Fic; pfam02661 552811004420 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 552811004421 HNH endonuclease; Region: HNH_2; pfam13391 552811004422 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 552811004423 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 552811004424 homodimer interface [polypeptide binding]; other site 552811004425 substrate-cofactor binding pocket; other site 552811004426 catalytic residue [active] 552811004427 membrane protein; Provisional; Region: PRK14416 552811004428 LysE type translocator; Region: LysE; pfam01810 552811004429 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 552811004430 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 552811004431 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 552811004432 Walker A/P-loop; other site 552811004433 ATP binding site [chemical binding]; other site 552811004434 Q-loop/lid; other site 552811004435 ABC transporter signature motif; other site 552811004436 Walker B; other site 552811004437 D-loop; other site 552811004438 H-loop/switch region; other site 552811004439 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 552811004440 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 552811004441 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 552811004442 5S rRNA interface [nucleotide binding]; other site 552811004443 CTC domain interface [polypeptide binding]; other site 552811004444 L16 interface [polypeptide binding]; other site 552811004445 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 552811004446 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 552811004447 Walker A/P-loop; other site 552811004448 ATP binding site [chemical binding]; other site 552811004449 Q-loop/lid; other site 552811004450 ABC transporter signature motif; other site 552811004451 Walker B; other site 552811004452 D-loop; other site 552811004453 H-loop/switch region; other site 552811004454 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 552811004455 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 552811004456 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 552811004457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 552811004458 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 552811004459 Coenzyme A binding pocket [chemical binding]; other site 552811004460 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 552811004461 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 552811004462 Helix-turn-helix domain; Region: HTH_17; pfam12728 552811004463 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 552811004464 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 552811004465 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 552811004466 putative active site pocket [active] 552811004467 dimerization interface [polypeptide binding]; other site 552811004468 putative catalytic residue [active] 552811004469 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 552811004470 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 552811004471 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 552811004472 UGMP family protein; Validated; Region: PRK09604 552811004473 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 552811004474 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 552811004475 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 552811004476 oligomerisation interface [polypeptide binding]; other site 552811004477 mobile loop; other site 552811004478 roof hairpin; other site 552811004479 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 552811004480 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 552811004481 ring oligomerisation interface [polypeptide binding]; other site 552811004482 ATP/Mg binding site [chemical binding]; other site 552811004483 stacking interactions; other site 552811004484 hinge regions; other site 552811004485 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 552811004486 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 552811004487 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 552811004488 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 552811004489 Acylphosphatase; Region: Acylphosphatase; pfam00708 552811004490 HypF finger; Region: zf-HYPF; pfam07503 552811004491 HypF finger; Region: zf-HYPF; pfam07503 552811004492 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 552811004493 HupF/HypC family; Region: HupF_HypC; pfam01455 552811004494 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 552811004495 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 552811004496 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 552811004497 dimerization interface [polypeptide binding]; other site 552811004498 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 552811004499 ATP binding site [chemical binding]; other site 552811004500 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 552811004501 Domain of unknown function DUF21; Region: DUF21; pfam01595 552811004502 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 552811004503 Transporter associated domain; Region: CorC_HlyC; smart01091 552811004504 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 552811004505 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 552811004506 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 552811004507 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 552811004508 YcfA-like protein; Region: YcfA; pfam07927 552811004509 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 552811004510 catalytic core [active] 552811004511 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 552811004512 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 552811004513 TilS substrate C-terminal domain; Region: TilS_C; smart00977 552811004514 Methyltransferase domain; Region: Methyltransf_31; pfam13847 552811004515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 552811004516 S-adenosylmethionine binding site [chemical binding]; other site 552811004517 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 552811004518 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 552811004519 nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662 552811004520 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 552811004521 active site 552811004522 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 552811004523 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 552811004524 purine monophosphate binding site [chemical binding]; other site 552811004525 dimer interface [polypeptide binding]; other site 552811004526 putative catalytic residues [active] 552811004527 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 552811004528 Transposase domain (DUF772); Region: DUF772; pfam05598 552811004529 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 552811004530 DDE superfamily endonuclease; Region: DDE_4; cl17710 552811004531 chaperone protein DnaJ; Provisional; Region: PRK14299 552811004532 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 552811004533 HSP70 interaction site [polypeptide binding]; other site 552811004534 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 552811004535 substrate binding site [polypeptide binding]; other site 552811004536 dimer interface [polypeptide binding]; other site 552811004537 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 552811004538 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 552811004539 DNA binding residues [nucleotide binding] 552811004540 putative dimer interface [polypeptide binding]; other site 552811004541 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 552811004542 Clp amino terminal domain; Region: Clp_N; pfam02861 552811004543 Clp amino terminal domain; Region: Clp_N; pfam02861 552811004544 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 552811004545 Walker A motif; other site 552811004546 ATP binding site [chemical binding]; other site 552811004547 Walker B motif; other site 552811004548 arginine finger; other site 552811004549 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 552811004550 Walker A motif; other site 552811004551 ATP binding site [chemical binding]; other site 552811004552 Walker B motif; other site 552811004553 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 552811004554 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 552811004555 CTP synthetase; Validated; Region: pyrG; PRK05380 552811004556 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 552811004557 Catalytic site [active] 552811004558 active site 552811004559 UTP binding site [chemical binding]; other site 552811004560 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 552811004561 active site 552811004562 putative oxyanion hole; other site 552811004563 catalytic triad [active] 552811004564 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 552811004565 active site 552811004566 intersubunit interactions; other site 552811004567 catalytic residue [active] 552811004568 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 552811004569 four helix bundle protein; Region: TIGR02436 552811004570 transcription termination factor Rho; Provisional; Region: rho; PRK09376 552811004571 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 552811004572 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 552811004573 RNA binding site [nucleotide binding]; other site 552811004574 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 552811004575 Walker A motif; other site 552811004576 ATP binding site [chemical binding]; other site 552811004577 Walker B motif; other site 552811004578 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 552811004579 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 552811004580 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 552811004581 YcfA-like protein; Region: YcfA; pfam07927 552811004582 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 552811004583 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 552811004584 YcfA-like protein; Region: YcfA; pfam07927 552811004585 LabA_like proteins; Region: LabA_like; cd06167 552811004586 putative metal binding site [ion binding]; other site 552811004587 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 552811004588 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 552811004589 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 552811004590 HicB family; Region: HicB; pfam05534 552811004591 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 552811004592 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 552811004593 TM-ABC transporter signature motif; other site 552811004594 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 552811004595 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 552811004596 TM-ABC transporter signature motif; other site 552811004597 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 552811004598 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 552811004599 Walker A/P-loop; other site 552811004600 ATP binding site [chemical binding]; other site 552811004601 Q-loop/lid; other site 552811004602 ABC transporter signature motif; other site 552811004603 Walker B; other site 552811004604 D-loop; other site 552811004605 H-loop/switch region; other site 552811004606 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 552811004607 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 552811004608 Walker A/P-loop; other site 552811004609 ATP binding site [chemical binding]; other site 552811004610 Q-loop/lid; other site 552811004611 ABC transporter signature motif; other site 552811004612 Walker B; other site 552811004613 D-loop; other site 552811004614 H-loop/switch region; other site 552811004615 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 552811004616 active site 552811004617 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 552811004618 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 552811004619 HerA helicase [Replication, recombination, and repair]; Region: COG0433 552811004620 HAS barrel domain; Region: HAS-barrel; pfam09378 552811004621 Domain of unknown function DUF87; Region: DUF87; pfam01935 552811004622 pyruvate kinase; Provisional; Region: PRK09206 552811004623 NurA nuclease; Region: NurA; smart00933 552811004624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 552811004625 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 552811004626 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 552811004627 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 552811004628 active site 552811004629 Zn binding site [ion binding]; other site 552811004630 ABC1 family; Region: ABC1; cl17513 552811004631 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 552811004632 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 552811004633 P loop; other site 552811004634 Nucleotide binding site [chemical binding]; other site 552811004635 DTAP/Switch II; other site 552811004636 Switch I; other site 552811004637 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 552811004638 Protein export membrane protein; Region: SecD_SecF; cl14618 552811004639 protein-export membrane protein SecD; Region: secD; TIGR01129 552811004640 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 552811004641 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 552811004642 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 552811004643 metal binding triad [ion binding]; metal-binding site 552811004644 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 552811004645 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 552811004646 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 552811004647 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 552811004648 non-specific DNA binding site [nucleotide binding]; other site 552811004649 salt bridge; other site 552811004650 sequence-specific DNA binding site [nucleotide binding]; other site 552811004651 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 552811004652 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 552811004653 ATP binding site [chemical binding]; other site 552811004654 putative Mg++ binding site [ion binding]; other site 552811004655 helicase superfamily c-terminal domain; Region: HELICc; smart00490 552811004656 ATP-binding site [chemical binding]; other site 552811004657 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 552811004658 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 552811004659 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 552811004660 Preprotein translocase SecG subunit; Region: SecG; cl09123 552811004661 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 552811004662 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 552811004663 GatB domain; Region: GatB_Yqey; smart00845 552811004664 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 552811004665 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 552811004666 catalytic residues [active] 552811004667 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 552811004668 SmpB-tmRNA interface; other site 552811004669 Hemerythrin-like domain; Region: Hr-like; cd12108 552811004670 Fe binding site [ion binding]; other site 552811004671 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 552811004672 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 552811004673 DNA binding residues [nucleotide binding] 552811004674 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 552811004675 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 552811004676 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 552811004677 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 552811004678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 552811004679 putative substrate translocation pore; other site 552811004680 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 552811004681 Prephenate dehydratase; Region: PDT; pfam00800 552811004682 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 552811004683 putative L-Phe binding site [chemical binding]; other site 552811004684 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 552811004685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552811004686 active site 552811004687 phosphorylation site [posttranslational modification] 552811004688 intermolecular recognition site; other site 552811004689 dimerization interface [polypeptide binding]; other site 552811004690 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 552811004691 DNA binding residues [nucleotide binding] 552811004692 dimerization interface [polypeptide binding]; other site 552811004693 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 552811004694 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 552811004695 Histidine kinase; Region: HisKA_3; pfam07730 552811004696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552811004697 ATP binding site [chemical binding]; other site 552811004698 Mg2+ binding site [ion binding]; other site 552811004699 G-X-G motif; other site 552811004700 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 552811004701 dimerization interface [polypeptide binding]; other site 552811004702 putative ATP binding site [chemical binding]; other site 552811004703 selenocysteine synthase; Provisional; Region: PRK04311 552811004704 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 552811004705 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 552811004706 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 552811004707 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 552811004708 G1 box; other site 552811004709 putative GEF interaction site [polypeptide binding]; other site 552811004710 GTP/Mg2+ binding site [chemical binding]; other site 552811004711 Switch I region; other site 552811004712 G2 box; other site 552811004713 G3 box; other site 552811004714 Switch II region; other site 552811004715 G4 box; other site 552811004716 G5 box; other site 552811004717 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 552811004718 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 552811004719 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 552811004720 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 552811004721 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 552811004722 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 552811004723 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 552811004724 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 552811004725 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 552811004726 TrkA-N domain; Region: TrkA_N; pfam02254 552811004727 TrkA-C domain; Region: TrkA_C; pfam02080 552811004728 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 552811004729 TrkA-N domain; Region: TrkA_N; pfam02254 552811004730 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 552811004731 Ligand Binding Site [chemical binding]; other site 552811004732 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 552811004733 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 552811004734 G1 box; other site 552811004735 putative GEF interaction site [polypeptide binding]; other site 552811004736 GTP/Mg2+ binding site [chemical binding]; other site 552811004737 Switch I region; other site 552811004738 G2 box; other site 552811004739 G3 box; other site 552811004740 Switch II region; other site 552811004741 G4 box; other site 552811004742 G5 box; other site 552811004743 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 552811004744 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 552811004745 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 552811004746 active site 552811004747 metal binding site [ion binding]; metal-binding site 552811004748 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 552811004749 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 552811004750 S-adenosylmethionine binding site [chemical binding]; other site 552811004751 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 552811004752 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 552811004753 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 552811004754 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 552811004755 reductive dehalogenase; Region: RDH; TIGR02486 552811004756 4Fe-4S binding domain; Region: Fer4; pfam00037 552811004757 Transposase, Mutator family; Region: Transposase_mut; pfam00872 552811004758 MULE transposase domain; Region: MULE; pfam10551 552811004759 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 552811004760 AAA ATPase domain; Region: AAA_16; pfam13191 552811004761 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 552811004762 DNA binding residues [nucleotide binding] 552811004763 dimerization interface [polypeptide binding]; other site 552811004764 Beta propeller domain; Region: Beta_propel; pfam09826 552811004765 Cytochrome c; Region: Cytochrom_C; pfam00034 552811004766 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 552811004767 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 552811004768 non-specific DNA binding site [nucleotide binding]; other site 552811004769 salt bridge; other site 552811004770 sequence-specific DNA binding site [nucleotide binding]; other site 552811004771 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 552811004772 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 552811004773 Transposase; Region: HTH_Tnp_1; pfam01527 552811004774 putative transposase OrfB; Reviewed; Region: PHA02517 552811004775 Integrase core domain; Region: rve; pfam00665 552811004776 Integrase core domain; Region: rve_3; pfam13683 552811004777 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 552811004778 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 552811004779 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 552811004780 reductive dehalogenase; Region: RDH; TIGR02486 552811004781 4Fe-4S binding domain; Region: Fer4; pfam00037 552811004782 putative transposase OrfB; Reviewed; Region: PHA02517 552811004783 Integrase core domain; Region: rve; pfam00665 552811004784 Integrase core domain; Region: rve_3; pfam13683 552811004785 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 552811004786 Transposase; Region: HTH_Tnp_1; pfam01527 552811004787 Transposase, Mutator family; Region: Transposase_mut; pfam00872 552811004788 MULE transposase domain; Region: MULE; pfam10551 552811004789 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 552811004790 reductive dehalogenase; Region: RDH; TIGR02486 552811004791 Response regulator receiver domain; Region: Response_reg; pfam00072 552811004792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552811004793 active site 552811004794 phosphorylation site [posttranslational modification] 552811004795 intermolecular recognition site; other site 552811004796 dimerization interface [polypeptide binding]; other site 552811004797 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 552811004798 DNA binding residues [nucleotide binding] 552811004799 GAF domain; Region: GAF; pfam01590 552811004800 GAF domain; Region: GAF_2; pfam13185 552811004801 PAS domain S-box; Region: sensory_box; TIGR00229 552811004802 PAS domain; Region: PAS; smart00091 552811004803 putative active site [active] 552811004804 heme pocket [chemical binding]; other site 552811004805 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 552811004806 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552811004807 ATP binding site [chemical binding]; other site 552811004808 Mg2+ binding site [ion binding]; other site 552811004809 G-X-G motif; other site 552811004810 Transposase; Region: DEDD_Tnp_IS110; pfam01548 552811004811 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 552811004812 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 552811004813 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 552811004814 Mechanosensitive ion channel; Region: MS_channel; pfam00924 552811004815 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 552811004816 EDD domain protein, DegV family; Region: DegV; TIGR00762 552811004817 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 552811004818 Protein of unknown function DUF45; Region: DUF45; pfam01863 552811004819 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 552811004820 reductive dehalogenase; Region: RDH; TIGR02486 552811004821 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 552811004822 Transposase; Region: HTH_Tnp_1; pfam01527 552811004823 putative transposase OrfB; Reviewed; Region: PHA02517 552811004824 Integrase core domain; Region: rve; pfam00665 552811004825 Integrase core domain; Region: rve_3; pfam13683 552811004826 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 552811004827 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 552811004828 dimerization interface [polypeptide binding]; other site 552811004829 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 552811004830 dimer interface [polypeptide binding]; other site 552811004831 phosphorylation site [posttranslational modification] 552811004832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552811004833 ATP binding site [chemical binding]; other site 552811004834 Mg2+ binding site [ion binding]; other site 552811004835 G-X-G motif; other site 552811004836 DDE domain; Region: DDE_Tnp_IS240; pfam13610 552811004837 Integrase core domain; Region: rve; pfam00665 552811004838 Integrase core domain; Region: rve_3; pfam13683 552811004839 Beta/Gamma crystallin; Region: Crystall; cl02528 552811004840 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 552811004841 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 552811004842 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 552811004843 dimerization interface [polypeptide binding]; other site 552811004844 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 552811004845 dimer interface [polypeptide binding]; other site 552811004846 phosphorylation site [posttranslational modification] 552811004847 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 552811004848 ATP binding site [chemical binding]; other site 552811004849 Mg2+ binding site [ion binding]; other site 552811004850 G-X-G motif; other site 552811004851 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 552811004852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552811004853 active site 552811004854 phosphorylation site [posttranslational modification] 552811004855 intermolecular recognition site; other site 552811004856 dimerization interface [polypeptide binding]; other site 552811004857 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 552811004858 DNA binding site [nucleotide binding] 552811004859 Beta/Gamma crystallin; Region: Crystall; cl02528 552811004860 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 552811004861 Transposase; Region: HTH_Tnp_1; pfam01527 552811004862 putative transposase OrfB; Reviewed; Region: PHA02517 552811004863 Integrase core domain; Region: rve; pfam00665 552811004864 Integrase core domain; Region: rve_3; pfam13683 552811004865 Transposase, Mutator family; Region: Transposase_mut; pfam00872 552811004866 MULE transposase domain; Region: MULE; pfam10551 552811004867 Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336 552811004868 PemK-like protein; Region: PemK; cl00995 552811004869 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 552811004870 oligomeric interface; other site 552811004871 putative active site [active] 552811004872 homodimer interface [polypeptide binding]; other site 552811004873 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 552811004874 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 552811004875 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 552811004876 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 552811004877 Walker A/P-loop; other site 552811004878 ATP binding site [chemical binding]; other site 552811004879 Q-loop/lid; other site 552811004880 ABC transporter signature motif; other site 552811004881 Walker B; other site 552811004882 D-loop; other site 552811004883 H-loop/switch region; other site 552811004884 Uncharacterized conserved protein [Function unknown]; Region: COG3391 552811004885 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 552811004886 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 552811004887 active site 552811004888 PHP Thumb interface [polypeptide binding]; other site 552811004889 metal binding site [ion binding]; metal-binding site 552811004890 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 552811004891 generic binding surface II; other site 552811004892 generic binding surface I; other site 552811004893 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 552811004894 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 552811004895 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 552811004896 active site clefts [active] 552811004897 zinc binding site [ion binding]; other site 552811004898 dimer interface [polypeptide binding]; other site 552811004899 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 552811004900 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 552811004901 reductive dehalogenase; Region: RDH; TIGR02486 552811004902 Transposase, Mutator family; Region: Transposase_mut; pfam00872 552811004903 MULE transposase domain; Region: MULE; pfam10551 552811004904 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 552811004905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 552811004906 active site 552811004907 phosphorylation site [posttranslational modification] 552811004908 intermolecular recognition site; other site 552811004909 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 552811004910 DNA binding residues [nucleotide binding] 552811004911 dimerization interface [polypeptide binding]; other site 552811004912 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 552811004913 Transposase domain (DUF772); Region: DUF772; pfam05598 552811004914 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 552811004915 DDE superfamily endonuclease; Region: DDE_4; cl17710 552811004916 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 552811004917 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 552811004918 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 552811004919 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 552811004920 active site 552811004921 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 552811004922 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 552811004923 minor groove reading motif; other site 552811004924 helix-hairpin-helix signature motif; other site 552811004925 substrate binding pocket [chemical binding]; other site 552811004926 active site 552811004927 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 552811004928 homodimer interaction site [polypeptide binding]; other site 552811004929 cofactor binding site; other site 552811004930 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 552811004931 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 552811004932 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 552811004933 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 552811004934 4Fe-4S binding domain; Region: Fer4; pfam00037 552811004935 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 552811004936 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 552811004937 substrate binding pocket [chemical binding]; other site 552811004938 membrane-bound complex binding site; other site 552811004939 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 552811004940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 552811004941 dimer interface [polypeptide binding]; other site 552811004942 conserved gate region; other site 552811004943 putative PBP binding loops; other site 552811004944 ABC-ATPase subunit interface; other site 552811004945 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 552811004946 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 552811004947 Walker A/P-loop; other site 552811004948 ATP binding site [chemical binding]; other site 552811004949 Q-loop/lid; other site 552811004950 ABC transporter signature motif; other site 552811004951 Walker B; other site 552811004952 D-loop; other site 552811004953 H-loop/switch region; other site 552811004954 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 552811004955 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 552811004956 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 552811004957 dimer interface [polypeptide binding]; other site 552811004958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 552811004959 catalytic residue [active] 552811004960 SirA-like protein; Region: SirA; pfam01206 552811004961 CPxP motif; other site 552811004962 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 552811004963 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 552811004964 Predicted permease; Region: DUF318; cl17795 552811004965 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 552811004966 arsenical-resistance protein; Region: acr3; TIGR00832 552811004967 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 552811004968 dimerization interface [polypeptide binding]; other site 552811004969 putative DNA binding site [nucleotide binding]; other site 552811004970 putative Zn2+ binding site [ion binding]; other site 552811004971 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 552811004972 Protein export membrane protein; Region: SecD_SecF; cl14618 552811004973 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 552811004974 MarR family; Region: MarR; pfam01047 552811004975 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 552811004976 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 552811004977 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 552811004978 RmuC family; Region: RmuC; pfam02646 552811004979 Restriction endonuclease [Defense mechanisms]; Region: COG3587 552811004980 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 552811004981 ATP binding site [chemical binding]; other site 552811004982 putative Mg++ binding site [ion binding]; other site 552811004983 Virulence protein [General function prediction only]; Region: COG3943 552811004984 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 552811004985 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 552811004986 DNA methylase; Region: N6_N4_Mtase; cl17433 552811004987 DNA methylase; Region: N6_N4_Mtase; pfam01555 552811004988 DNA methylase; Region: N6_N4_Mtase; cl17433 552811004989 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 552811004990 ATP binding site [chemical binding]; other site 552811004991 putative Mg++ binding site [ion binding]; other site 552811004992 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 552811004993 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 552811004994 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 552811004995 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 552811004996 Transposase, Mutator family; Region: Transposase_mut; pfam00872 552811004997 MULE transposase domain; Region: MULE; pfam10551 552811004998 Transposase, Mutator family; Region: Transposase_mut; pfam00872 552811004999 MULE transposase domain; Region: MULE; pfam10551 552811005000 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 552811005001 ATP binding site [chemical binding]; other site 552811005002 putative Mg++ binding site [ion binding]; other site 552811005003 nucleotide binding region [chemical binding]; other site 552811005004 helicase superfamily c-terminal domain; Region: HELICc; smart00490 552811005005 ATP-binding site [chemical binding]; other site 552811005006 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 552811005007 DNA protecting protein DprA; Region: dprA; TIGR00732 552811005008 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 552811005009 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 552811005010 active site 552811005011 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 552811005012 MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown; Region: MIT_C; cd02685 552811005013 TIGR02687 family protein; Region: TIGR02687 552811005014 PglZ domain; Region: PglZ; pfam08665 552811005015 Methyltransferase domain; Region: Methyltransf_26; pfam13659 552811005016 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 552811005017 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 552811005018 DNA binding domain, excisionase family; Region: excise; TIGR01764 552811005019 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 552811005020 putative active site pocket [active] 552811005021 dimerization interface [polypeptide binding]; other site 552811005022 putative catalytic residue [active] 552811005023 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cd00352 552811005024 active site 552811005025 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 552811005026 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 552811005027 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 552811005028 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 552811005029 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 552811005030 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 552811005031 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 552811005032 PAAR motif; Region: PAAR_motif; pfam05488 552811005033 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 552811005034 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 552811005035 Peptidase M15; Region: Peptidase_M15_3; cl01194 552811005036 Phage protein D [General function prediction only]; Region: COG3500 552811005037 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 552811005038 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 552811005039 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 552811005040 Phage-related protein [Function unknown]; Region: COG5412 552811005041 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 552811005042 tail sheath protein; Provisional; Region: 18; PHA02539 552811005043 tail sheath protein; Provisional; Region: 18; PHA02539 552811005044 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 552811005045 Transposase; Region: HTH_Tnp_1; pfam01527 552811005046 putative transposase OrfB; Reviewed; Region: PHA02517 552811005047 Integrase core domain; Region: rve; pfam00665 552811005048 Integrase core domain; Region: rve_3; pfam13683 552811005049 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 552811005050 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 552811005051 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 552811005052 ligand binding site [chemical binding]; other site 552811005053 flexible hinge region; other site 552811005054 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 552811005055 putative switch regulator; other site 552811005056 non-specific DNA interactions [nucleotide binding]; other site 552811005057 DNA binding site [nucleotide binding] 552811005058 sequence specific DNA binding site [nucleotide binding]; other site 552811005059 putative cAMP binding site [chemical binding]; other site 552811005060 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 552811005061 DsrE/DsrF-like family; Region: DrsE; cl00672 552811005062 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 552811005063 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 552811005064 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 552811005065 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 552811005066 putative catalytic residues [active] 552811005067 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 552811005068 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 552811005069 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 552811005070 SprA-related family; Region: SprA-related; pfam12118 552811005071 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 552811005072 Helix-turn-helix domain; Region: HTH_17; pfam12728 552811005073 Part of AAA domain; Region: AAA_19; pfam13245 552811005074 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 552811005075 AAA domain; Region: AAA_12; pfam13087 552811005076 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 552811005077 putative active site [active] 552811005078 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 552811005079 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 552811005080 Phage portal protein; Region: Phage_portal; pfam04860 552811005081 Terminase-like family; Region: Terminase_6; pfam03237 552811005082 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 552811005083 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 552811005084 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 552811005085 active site 552811005086 DNA binding site [nucleotide binding] 552811005087 Int/Topo IB signature motif; other site 552811005088 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 552811005089 DNA primase, catalytic core; Region: dnaG; TIGR01391 552811005090 CHC2 zinc finger; Region: zf-CHC2; cl17510 552811005091 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 552811005092 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 552811005093 active site 552811005094 metal binding site [ion binding]; metal-binding site 552811005095 interdomain interaction site; other site 552811005096 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 552811005097 AAA domain; Region: AAA_30; pfam13604 552811005098 Family description; Region: UvrD_C_2; pfam13538 552811005099 ERCC4 domain; Region: ERCC4; smart00891 552811005100 Protein of unknown function (DUF669); Region: DUF669; pfam05037 552811005101 AAA domain; Region: AAA_24; pfam13479 552811005102 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 552811005103 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 552811005104 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 552811005105 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 552811005106 LexA repressor; Validated; Region: PRK00215 552811005107 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 552811005108 Catalytic site [active] 552811005109 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 552811005110 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 552811005111 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 552811005112 catalytic residues [active] 552811005113 catalytic nucleophile [active] 552811005114 Presynaptic Site I dimer interface [polypeptide binding]; other site 552811005115 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 552811005116 Synaptic Flat tetramer interface [polypeptide binding]; other site 552811005117 Synaptic Site I dimer interface [polypeptide binding]; other site 552811005118 DNA binding site [nucleotide binding] 552811005119 Recombinase; Region: Recombinase; pfam07508 552811005120 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 552811005121 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 552811005122 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 552811005123 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 552811005124 Predicted integral membrane protein [Function unknown]; Region: COG5658 552811005125 SdpI/YhfL protein family; Region: SdpI; pfam13630 552811005126 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 552811005127 dimerization interface [polypeptide binding]; other site 552811005128 putative DNA binding site [nucleotide binding]; other site 552811005129 putative Zn2+ binding site [ion binding]; other site 552811005130 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 552811005131 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 552811005132 active site 552811005133 HIGH motif; other site 552811005134 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 552811005135 KMSKS motif; other site 552811005136 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 552811005137 tRNA binding surface [nucleotide binding]; other site 552811005138 anticodon binding site; other site 552811005139 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 552811005140 homotrimer interaction site [polypeptide binding]; other site 552811005141 zinc binding site [ion binding]; other site 552811005142 CDP-binding sites; other site 552811005143 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 552811005144 substrate binding site; other site 552811005145 dimer interface; other site 552811005146 hypothetical protein; Reviewed; Region: PRK00024 552811005147 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 552811005148 MPN+ (JAMM) motif; other site 552811005149 Zinc-binding site [ion binding]; other site 552811005150 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 552811005151 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 552811005152 DNA binding site [nucleotide binding] 552811005153 active site 552811005154 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 552811005155 30S subunit binding site; other site 552811005156 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 552811005157 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 552811005158 active site 552811005159 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 552811005160 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 552811005161 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 552811005162 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 552811005163 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 552811005164 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 552811005165 putative active site [active] 552811005166 substrate binding site [chemical binding]; other site 552811005167 putative cosubstrate binding site; other site 552811005168 catalytic site [active] 552811005169 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 552811005170 substrate binding site [chemical binding]; other site