-- dump date 20140619_060253 -- class Genbank::misc_feature -- table misc_feature_note -- id note 319795000001 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 319795000002 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 319795000003 P-loop; other site 319795000004 Magnesium ion binding site [ion binding]; other site 319795000005 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 319795000006 Magnesium ion binding site [ion binding]; other site 319795000007 ParB-like nuclease domain; Region: ParB; smart00470 319795000008 Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like2; cd08198 319795000009 active site 319795000010 metal binding site [ion binding]; metal-binding site 319795000011 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 319795000012 active site 319795000013 TatD related DNase; Region: TatD_DNase; pfam01026 319795000014 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 319795000015 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 319795000016 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 319795000017 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 319795000018 Predicted membrane protein [Function unknown]; Region: COG1511 319795000019 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 319795000020 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 319795000021 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 319795000022 Transglycosylase; Region: Transgly; pfam00912 319795000023 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 319795000024 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 319795000025 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 319795000026 ligand binding site [chemical binding]; other site 319795000027 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 319795000028 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 319795000029 TM-ABC transporter signature motif; other site 319795000030 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 319795000031 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 319795000032 TM-ABC transporter signature motif; other site 319795000033 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 319795000034 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 319795000035 Walker A/P-loop; other site 319795000036 ATP binding site [chemical binding]; other site 319795000037 Q-loop/lid; other site 319795000038 ABC transporter signature motif; other site 319795000039 Walker B; other site 319795000040 D-loop; other site 319795000041 H-loop/switch region; other site 319795000042 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 319795000043 Domain of unknown function (DUF718); Region: DUF718; pfam05336 319795000044 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 319795000045 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 319795000046 DNA-binding site [nucleotide binding]; DNA binding site 319795000047 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 319795000048 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 319795000049 short chain dehydrogenase; Validated; Region: PRK08324 319795000050 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 319795000051 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 319795000052 putative NAD(P) binding site [chemical binding]; other site 319795000053 active site 319795000054 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 319795000055 N- and C-terminal domain interface [polypeptide binding]; other site 319795000056 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 319795000057 active site 319795000058 putative catalytic site [active] 319795000059 metal binding site [ion binding]; metal-binding site 319795000060 ATP binding site [chemical binding]; other site 319795000061 carbohydrate binding site [chemical binding]; other site 319795000062 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 319795000063 Cysteine-rich domain; Region: CCG; pfam02754 319795000064 Cysteine-rich domain; Region: CCG; pfam02754 319795000065 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 319795000066 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 319795000067 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 319795000068 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 319795000069 DDE superfamily endonuclease; Region: DDE_4; cl17710 319795000070 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795000071 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 319795000072 Integrase core domain; Region: rve_3; pfam13683 319795000073 Iron permease FTR1 family; Region: FTR1; cl00475 319795000074 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 319795000075 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 319795000076 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 319795000077 Domain of unknown function DUF11; Region: DUF11; cl17728 319795000078 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795000079 Predicted membrane protein [Function unknown]; Region: COG4655 319795000080 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 319795000081 Domain of unknown function DUF11; Region: DUF11; cl17728 319795000082 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 319795000083 Predicted membrane protein [Function unknown]; Region: COG1470 319795000084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719 319795000085 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795000086 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 319795000087 H-loop/switch region; other site 319795000088 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 319795000089 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 319795000090 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 319795000091 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 319795000092 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 319795000093 Walker A/P-loop; other site 319795000094 ATP binding site [chemical binding]; other site 319795000095 Q-loop/lid; other site 319795000096 ABC transporter signature motif; other site 319795000097 Walker B; other site 319795000098 D-loop; other site 319795000099 H-loop/switch region; other site 319795000100 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 319795000101 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 319795000102 TM-ABC transporter signature motif; other site 319795000103 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 319795000104 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 319795000105 Walker A/P-loop; other site 319795000106 ATP binding site [chemical binding]; other site 319795000107 Q-loop/lid; other site 319795000108 ABC transporter signature motif; other site 319795000109 Walker B; other site 319795000110 D-loop; other site 319795000111 H-loop/switch region; other site 319795000112 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 319795000113 TM-ABC transporter signature motif; other site 319795000114 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 319795000115 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 319795000116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 319795000117 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 319795000118 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 319795000119 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 319795000120 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 319795000121 tetramer interface [polypeptide binding]; other site 319795000122 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 319795000123 tetramer interface [polypeptide binding]; other site 319795000124 active site 319795000125 metal binding site [ion binding]; metal-binding site 319795000126 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 319795000127 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 319795000128 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 319795000129 extended (e) SDRs; Region: SDR_e; cd08946 319795000130 NAD(P) binding site [chemical binding]; other site 319795000131 active site 319795000132 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 319795000133 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 319795000134 NAD binding site [chemical binding]; other site 319795000135 catalytic residues [active] 319795000136 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 319795000137 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 319795000138 active site 319795000139 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 319795000140 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 319795000141 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 319795000142 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 319795000143 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 319795000144 putative ligand binding site [chemical binding]; other site 319795000145 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 319795000146 FAD binding domain; Region: FAD_binding_4; pfam01565 319795000147 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 319795000148 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 319795000149 acyl-activating enzyme (AAE) consensus motif; other site 319795000150 AMP binding site [chemical binding]; other site 319795000151 active site 319795000152 CoA binding site [chemical binding]; other site 319795000153 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 319795000154 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 319795000155 cation binding site [ion binding]; other site 319795000156 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 319795000157 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 319795000158 DNA binding residues [nucleotide binding] 319795000159 dimer interface [polypeptide binding]; other site 319795000160 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 319795000161 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 319795000162 NAD(P) binding site [chemical binding]; other site 319795000163 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 319795000164 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 319795000165 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 319795000166 active site 319795000167 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 319795000168 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 319795000169 TAP-like protein; Region: Abhydrolase_4; pfam08386 319795000170 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 319795000171 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 319795000172 NAD(P) binding site [chemical binding]; other site 319795000173 active site 319795000174 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 319795000175 putative active site [active] 319795000176 putative catalytic site [active] 319795000177 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 319795000178 CoenzymeA binding site [chemical binding]; other site 319795000179 subunit interaction site [polypeptide binding]; other site 319795000180 PHB binding site; other site 319795000181 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 319795000182 Strictosidine synthase; Region: Str_synth; pfam03088 319795000183 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 319795000184 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 319795000185 FAD binding site [chemical binding]; other site 319795000186 substrate binding site [chemical binding]; other site 319795000187 catalytic base [active] 319795000188 hypothetical protein; Provisional; Region: PRK06194 319795000189 classical (c) SDRs; Region: SDR_c; cd05233 319795000190 NAD(P) binding site [chemical binding]; other site 319795000191 active site 319795000192 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 319795000193 Phosphotransferase enzyme family; Region: APH; pfam01636 319795000194 putative active site [active] 319795000195 putative substrate binding site [chemical binding]; other site 319795000196 ATP binding site [chemical binding]; other site 319795000197 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 319795000198 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974 319795000199 active site 319795000200 acyl-activating enzyme (AAE) consensus motif; other site 319795000201 putative CoA binding site [chemical binding]; other site 319795000202 AMP binding site [chemical binding]; other site 319795000203 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 319795000204 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 319795000205 putative active site cavity [active] 319795000206 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 319795000207 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 319795000208 active site 319795000209 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 319795000210 nitrite reductase subunit NirD; Provisional; Region: PRK14989 319795000211 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 319795000212 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 319795000213 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 319795000214 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 319795000215 [4Fe-4S] binding site [ion binding]; other site 319795000216 molybdopterin cofactor binding site; other site 319795000217 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 319795000218 molybdopterin cofactor binding site; other site 319795000219 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 319795000220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 319795000221 putative substrate translocation pore; other site 319795000222 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 319795000223 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 319795000224 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 319795000225 heterodimer interface [polypeptide binding]; other site 319795000226 multimer interface [polypeptide binding]; other site 319795000227 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 319795000228 active site 319795000229 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 319795000230 heterodimer interface [polypeptide binding]; other site 319795000231 active site 319795000232 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 319795000233 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 319795000234 tetramer interface [polypeptide binding]; other site 319795000235 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 319795000236 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 319795000237 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 319795000238 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 319795000239 Transcriptional regulator [Transcription]; Region: IclR; COG1414 319795000240 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 319795000241 Bacterial transcriptional regulator; Region: IclR; pfam01614 319795000242 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 319795000243 Transcriptional regulator [Transcription]; Region: IclR; COG1414 319795000244 Bacterial transcriptional regulator; Region: IclR; pfam01614 319795000245 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 319795000246 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 319795000247 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 319795000248 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 319795000249 active site 319795000250 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 319795000251 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 319795000252 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 319795000253 dimer interface [polypeptide binding]; other site 319795000254 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 319795000255 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 319795000256 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 319795000257 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 319795000258 NAD(P) binding site [chemical binding]; other site 319795000259 shikimate binding site; other site 319795000260 metabolite-proton symporter; Region: 2A0106; TIGR00883 319795000261 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 319795000262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 319795000263 putative substrate translocation pore; other site 319795000264 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 319795000265 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 319795000266 metal binding site [ion binding]; metal-binding site 319795000267 active site 319795000268 I-site; other site 319795000269 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 319795000270 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 319795000271 putative active site [active] 319795000272 putative metal binding site [ion binding]; other site 319795000273 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 319795000274 Cobalamin-5-phosphate synthase [Coenzyme metabolism]; Region: CobS; COG0368 319795000275 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 319795000276 catalytic core [active] 319795000277 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 319795000278 dimer interface [polypeptide binding]; other site 319795000279 Alkaline phosphatase homologues; Region: alkPPc; smart00098 319795000280 active site 319795000281 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 319795000282 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 319795000283 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 319795000284 putative binding site residues; other site 319795000285 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 319795000286 homodimer interface [polypeptide binding]; other site 319795000287 Walker A motif; other site 319795000288 ATP binding site [chemical binding]; other site 319795000289 hydroxycobalamin binding site [chemical binding]; other site 319795000290 Walker B motif; other site 319795000291 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 319795000292 active site 319795000293 putative homodimer interface [polypeptide binding]; other site 319795000294 SAM binding site [chemical binding]; other site 319795000295 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 319795000296 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 319795000297 putative active site [active] 319795000298 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 319795000299 putative active site [active] 319795000300 Precorrin-8X methylmutase; Region: CbiC; pfam02570 319795000301 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 319795000302 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 319795000303 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 319795000304 active site 319795000305 SAM binding site [chemical binding]; other site 319795000306 homodimer interface [polypeptide binding]; other site 319795000307 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 319795000308 active site 319795000309 SAM binding site [chemical binding]; other site 319795000310 homodimer interface [polypeptide binding]; other site 319795000311 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 319795000312 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 319795000313 cobalamin biosynthesis protein CbiG; Provisional; Region: PRK07027 319795000314 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 319795000315 active site 319795000316 SAM binding site [chemical binding]; other site 319795000317 homodimer interface [polypeptide binding]; other site 319795000318 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 319795000319 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 319795000320 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 319795000321 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 319795000322 High-affinity nickel-transport protein; Region: NicO; cl00964 319795000323 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 319795000324 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 319795000325 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 319795000326 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 319795000327 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 319795000328 S-adenosylmethionine binding site [chemical binding]; other site 319795000329 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 319795000330 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 319795000331 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 319795000332 metal ion-dependent adhesion site (MIDAS); other site 319795000333 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 319795000334 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 319795000335 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 319795000336 catalytic triad [active] 319795000337 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 319795000338 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 319795000339 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 319795000340 pyridoxal 5'-phosphate binding site [chemical binding]; other site 319795000341 homodimer interface [polypeptide binding]; other site 319795000342 catalytic residue [active] 319795000343 cobyric acid synthase; Provisional; Region: PRK00784 319795000344 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 319795000345 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 319795000346 catalytic triad [active] 319795000347 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 319795000348 homotrimer interface [polypeptide binding]; other site 319795000349 Walker A motif; other site 319795000350 GTP binding site [chemical binding]; other site 319795000351 Walker B motif; other site 319795000352 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 319795000353 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 319795000354 putative dimer interface [polypeptide binding]; other site 319795000355 active site pocket [active] 319795000356 putative cataytic base [active] 319795000357 Transcriptional regulators [Transcription]; Region: PurR; COG1609 319795000358 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 319795000359 DNA binding site [nucleotide binding] 319795000360 domain linker motif; other site 319795000361 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 319795000362 dimerization interface [polypeptide binding]; other site 319795000363 ligand binding site [chemical binding]; other site 319795000364 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 319795000365 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 319795000366 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 319795000367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795000368 dimer interface [polypeptide binding]; other site 319795000369 conserved gate region; other site 319795000370 putative PBP binding loops; other site 319795000371 ABC-ATPase subunit interface; other site 319795000372 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 319795000373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795000374 dimer interface [polypeptide binding]; other site 319795000375 conserved gate region; other site 319795000376 putative PBP binding loops; other site 319795000377 ABC-ATPase subunit interface; other site 319795000378 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 319795000379 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 319795000380 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 319795000381 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 319795000382 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 319795000383 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 319795000384 NAD(P) binding site [chemical binding]; other site 319795000385 active site 319795000386 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 319795000387 inhibitor binding site; inhibition site 319795000388 catalytic Zn binding site [ion binding]; other site 319795000389 structural Zn binding site [ion binding]; other site 319795000390 NADP binding site [chemical binding]; other site 319795000391 tetramer interface [polypeptide binding]; other site 319795000392 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 319795000393 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 319795000394 N- and C-terminal domain interface [polypeptide binding]; other site 319795000395 putative active site [active] 319795000396 MgATP binding site [chemical binding]; other site 319795000397 catalytic site [active] 319795000398 metal binding site [ion binding]; metal-binding site 319795000399 putative xylulose binding site [chemical binding]; other site 319795000400 putative homodimer interface [polypeptide binding]; other site 319795000401 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 319795000402 beta-galactosidase; Region: BGL; TIGR03356 319795000403 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 319795000404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795000405 dimer interface [polypeptide binding]; other site 319795000406 conserved gate region; other site 319795000407 putative PBP binding loops; other site 319795000408 ABC-ATPase subunit interface; other site 319795000409 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795000410 dimer interface [polypeptide binding]; other site 319795000411 conserved gate region; other site 319795000412 putative PBP binding loops; other site 319795000413 ABC-ATPase subunit interface; other site 319795000414 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 319795000415 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 319795000416 Transcriptional regulators [Transcription]; Region: PurR; COG1609 319795000417 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 319795000418 DNA binding site [nucleotide binding] 319795000419 domain linker motif; other site 319795000420 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_9; cd06290 319795000421 putative dimerization interface [polypeptide binding]; other site 319795000422 putative ligand binding site [chemical binding]; other site 319795000423 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 319795000424 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 319795000425 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 319795000426 Walker A/P-loop; other site 319795000427 ATP binding site [chemical binding]; other site 319795000428 Q-loop/lid; other site 319795000429 ABC transporter signature motif; other site 319795000430 Walker B; other site 319795000431 D-loop; other site 319795000432 H-loop/switch region; other site 319795000433 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 319795000434 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 319795000435 putative lipid kinase; Reviewed; Region: PRK13057 319795000436 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 319795000437 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 319795000438 Ligand Binding Site [chemical binding]; other site 319795000439 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 319795000440 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 319795000441 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 319795000442 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 319795000443 Soluble P-type ATPase [General function prediction only]; Region: COG4087 319795000444 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 319795000445 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 319795000446 ATP binding site [chemical binding]; other site 319795000447 Mg2+ binding site [ion binding]; other site 319795000448 G-X-G motif; other site 319795000449 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 319795000450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 319795000451 active site 319795000452 phosphorylation site [posttranslational modification] 319795000453 intermolecular recognition site; other site 319795000454 dimerization interface [polypeptide binding]; other site 319795000455 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 319795000456 DNA binding residues [nucleotide binding] 319795000457 dimerization interface [polypeptide binding]; other site 319795000458 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 319795000459 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 319795000460 dimerization interface [polypeptide binding]; other site 319795000461 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 319795000462 dimer interface [polypeptide binding]; other site 319795000463 phosphorylation site [posttranslational modification] 319795000464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 319795000465 ATP binding site [chemical binding]; other site 319795000466 Mg2+ binding site [ion binding]; other site 319795000467 G-X-G motif; other site 319795000468 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 319795000469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 319795000470 active site 319795000471 phosphorylation site [posttranslational modification] 319795000472 intermolecular recognition site; other site 319795000473 dimerization interface [polypeptide binding]; other site 319795000474 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 319795000475 DNA binding site [nucleotide binding] 319795000476 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 319795000477 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 319795000478 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 319795000479 putative active site [active] 319795000480 Transcriptional regulator [Transcription]; Region: LysR; COG0583 319795000481 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 319795000482 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 319795000483 putative dimerization interface [polypeptide binding]; other site 319795000484 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 319795000485 gating phenylalanine in ion channel; other site 319795000486 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 319795000487 sulfite oxidase; Provisional; Region: PLN00177 319795000488 Moco binding site; other site 319795000489 metal coordination site [ion binding]; other site 319795000490 Cytochrome c; Region: Cytochrom_C; cl11414 319795000491 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 319795000492 active site 319795000493 catalytic residues [active] 319795000494 Tetratricopeptide repeat; Region: TPR_12; pfam13424 319795000495 Tetratricopeptide repeat; Region: TPR_12; pfam13424 319795000496 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 319795000497 binding surface 319795000498 TPR motif; other site 319795000499 Tetratricopeptide repeat; Region: TPR_12; pfam13424 319795000500 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795000501 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 319795000502 Zn2+ binding site [ion binding]; other site 319795000503 Mg2+ binding site [ion binding]; other site 319795000504 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 319795000505 Q-loop/lid; other site 319795000506 D-loop; other site 319795000507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795000508 dimer interface [polypeptide binding]; other site 319795000509 conserved gate region; other site 319795000510 putative PBP binding loops; other site 319795000511 ABC-ATPase subunit interface; other site 319795000512 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 319795000513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795000514 dimer interface [polypeptide binding]; other site 319795000515 conserved gate region; other site 319795000516 putative PBP binding loops; other site 319795000517 ABC-ATPase subunit interface; other site 319795000518 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 319795000519 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 319795000520 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 319795000521 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 319795000522 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 319795000523 Melibiase; Region: Melibiase; pfam02065 319795000524 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 319795000525 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 319795000526 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 319795000527 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 319795000528 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311 319795000529 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 319795000530 putative ligand binding site [chemical binding]; other site 319795000531 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 319795000532 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 319795000533 TM-ABC transporter signature motif; other site 319795000534 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795000535 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 319795000536 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 319795000537 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 319795000538 putative active site [active] 319795000539 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 319795000540 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 319795000541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795000542 dimer interface [polypeptide binding]; other site 319795000543 conserved gate region; other site 319795000544 putative PBP binding loops; other site 319795000545 ABC-ATPase subunit interface; other site 319795000546 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 319795000547 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 319795000548 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 319795000549 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 319795000550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795000551 dimer interface [polypeptide binding]; other site 319795000552 conserved gate region; other site 319795000553 putative PBP binding loops; other site 319795000554 ABC-ATPase subunit interface; other site 319795000555 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 319795000556 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 319795000557 N- and C-terminal domain interface [polypeptide binding]; other site 319795000558 active site 319795000559 carbohydrate binding site [chemical binding]; other site 319795000560 ATP binding site [chemical binding]; other site 319795000561 Entner-Doudoroff aldolase; Region: eda; TIGR01182 319795000562 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 319795000563 active site 319795000564 intersubunit interface [polypeptide binding]; other site 319795000565 catalytic residue [active] 319795000566 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 319795000567 substrate binding site [chemical binding]; other site 319795000568 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 319795000569 ATP binding site [chemical binding]; other site 319795000570 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 319795000571 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 319795000572 active site 319795000573 intersubunit interface [polypeptide binding]; other site 319795000574 catalytic residue [active] 319795000575 galactonate dehydratase; Provisional; Region: PRK14017 319795000576 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 319795000577 putative active site pocket [active] 319795000578 putative metal binding site [ion binding]; other site 319795000579 Transcriptional regulator [Transcription]; Region: IclR; COG1414 319795000580 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 319795000581 Bacterial transcriptional regulator; Region: IclR; pfam01614 319795000582 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795000583 Transposase; Region: HTH_Tnp_1; pfam01527 319795000584 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 319795000585 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 319795000586 WYL domain; Region: WYL; pfam13280 319795000587 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 319795000588 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 319795000589 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 319795000590 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 319795000591 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 319795000592 active site 319795000593 catalytic residues [active] 319795000594 DDE superfamily endonuclease; Region: DDE_5; cl17874 319795000595 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795000596 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 319795000597 DDE superfamily endonuclease; Region: DDE_5; cl17874 319795000598 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795000599 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 319795000600 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 319795000601 DNA binding residues [nucleotide binding] 319795000602 dimerization interface [polypeptide binding]; other site 319795000603 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 319795000604 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 319795000605 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 319795000606 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 319795000607 NodB motif; other site 319795000608 active site 319795000609 catalytic site [active] 319795000610 metal binding site [ion binding]; metal-binding site 319795000611 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 319795000612 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 319795000613 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 319795000614 pyridoxal 5'-phosphate binding site [chemical binding]; other site 319795000615 homodimer interface [polypeptide binding]; other site 319795000616 catalytic residue [active] 319795000617 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 319795000618 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 319795000619 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 319795000620 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 319795000621 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 319795000622 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 319795000623 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 319795000624 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 319795000625 Transcriptional regulator [Transcription]; Region: IclR; COG1414 319795000626 Bacterial transcriptional regulator; Region: IclR; pfam01614 319795000627 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 319795000628 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 319795000629 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 319795000630 active site 319795000631 catalytic residues [active] 319795000632 DNA binding site [nucleotide binding] 319795000633 Int/Topo IB signature motif; other site 319795000634 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 319795000635 dimerization interface [polypeptide binding]; other site 319795000636 putative DNA binding site [nucleotide binding]; other site 319795000637 putative Zn2+ binding site [ion binding]; other site 319795000638 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 319795000639 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 319795000640 Sulfate transporter family; Region: Sulfate_transp; pfam00916 319795000641 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 319795000642 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 319795000643 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 319795000644 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 319795000645 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 319795000646 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 319795000647 active site 319795000648 metal binding site [ion binding]; metal-binding site 319795000649 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 319795000650 Low molecular weight phosphatase family; Region: LMWPc; cd00115 319795000651 active site 319795000652 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 319795000653 arsenical pump membrane protein; Provisional; Region: PRK15445 319795000654 transmembrane helices; other site 319795000655 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 319795000656 Low molecular weight phosphatase family; Region: LMWPc; cd00115 319795000657 active site 319795000658 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 319795000659 dimerization interface [polypeptide binding]; other site 319795000660 putative DNA binding site [nucleotide binding]; other site 319795000661 putative Zn2+ binding site [ion binding]; other site 319795000662 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 319795000663 catalytic site [active] 319795000664 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 319795000665 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 319795000666 active site 319795000667 substrate binding site [chemical binding]; other site 319795000668 catalytic site [active] 319795000669 DDE superfamily endonuclease; Region: DDE_5; cl17874 319795000670 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795000671 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 319795000672 Integrase core domain; Region: rve; pfam00665 319795000673 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 319795000674 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 319795000675 active site 319795000676 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 319795000677 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 319795000678 DNA-binding site [nucleotide binding]; DNA binding site 319795000679 UTRA domain; Region: UTRA; pfam07702 319795000680 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 319795000681 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 319795000682 Walker A/P-loop; other site 319795000683 ATP binding site [chemical binding]; other site 319795000684 Q-loop/lid; other site 319795000685 ABC transporter signature motif; other site 319795000686 Walker B; other site 319795000687 D-loop; other site 319795000688 H-loop/switch region; other site 319795000689 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 319795000690 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 319795000691 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 319795000692 putative PBP binding regions; other site 319795000693 ABC-ATPase subunit interface; other site 319795000694 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 319795000695 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 319795000696 siderophore binding site; other site 319795000697 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 319795000698 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 319795000699 ABC-ATPase subunit interface; other site 319795000700 dimer interface [polypeptide binding]; other site 319795000701 putative PBP binding regions; other site 319795000702 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 319795000703 putative dimer interface [polypeptide binding]; other site 319795000704 putative [2Fe-2S] cluster binding site [ion binding]; other site 319795000705 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 319795000706 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 319795000707 siderophore binding site; other site 319795000708 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 319795000709 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 319795000710 siderophore binding site; other site 319795000711 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 319795000712 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 319795000713 metal-binding site [ion binding] 319795000714 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 319795000715 Soluble P-type ATPase [General function prediction only]; Region: COG4087 319795000716 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 319795000717 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 319795000718 active site 319795000719 metal binding site [ion binding]; metal-binding site 319795000720 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 319795000721 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 319795000722 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 319795000723 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 319795000724 dimer interface [polypeptide binding]; other site 319795000725 phosphorylation site [posttranslational modification] 319795000726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 319795000727 ATP binding site [chemical binding]; other site 319795000728 Mg2+ binding site [ion binding]; other site 319795000729 G-X-G motif; other site 319795000730 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 319795000731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 319795000732 active site 319795000733 phosphorylation site [posttranslational modification] 319795000734 intermolecular recognition site; other site 319795000735 dimerization interface [polypeptide binding]; other site 319795000736 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 319795000737 DNA binding site [nucleotide binding] 319795000738 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 319795000739 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 319795000740 active site 319795000741 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 319795000742 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 319795000743 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 319795000744 4Fe-4S binding domain; Region: Fer4_6; pfam12837 319795000745 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 319795000746 [4Fe-4S] binding site [ion binding]; other site 319795000747 molybdopterin cofactor binding site; other site 319795000748 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 319795000749 molybdopterin cofactor binding site; other site 319795000750 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 319795000751 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 319795000752 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 319795000753 homodimer interface [polypeptide binding]; other site 319795000754 substrate-cofactor binding pocket; other site 319795000755 catalytic residue [active] 319795000756 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 319795000757 Ligand Binding Site [chemical binding]; other site 319795000758 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 319795000759 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 319795000760 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 319795000761 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 319795000762 dimerization interface [polypeptide binding]; other site 319795000763 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 319795000764 GAF domain; Region: GAF_3; pfam13492 319795000765 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 319795000766 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 319795000767 metal binding site [ion binding]; metal-binding site 319795000768 active site 319795000769 I-site; other site 319795000770 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 319795000771 Probable transposase; Region: OrfB_IS605; pfam01385 319795000772 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 319795000773 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 319795000774 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 319795000775 active site 319795000776 Int/Topo IB signature motif; other site 319795000777 catalytic residues [active] 319795000778 DNA binding site [nucleotide binding] 319795000779 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 319795000780 Bacterial transcriptional regulator; Region: IclR; pfam01614 319795000781 urocanate hydratase; Provisional; Region: PRK05414 319795000782 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 319795000783 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 319795000784 oligomeric interface; other site 319795000785 putative active site [active] 319795000786 homodimer interface [polypeptide binding]; other site 319795000787 agmatinase; Region: agmatinase; TIGR01230 319795000788 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 319795000789 active site 319795000790 metal binding site [ion binding]; metal-binding site 319795000791 imidazolonepropionase; Validated; Region: PRK09356 319795000792 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 319795000793 active site 319795000794 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 319795000795 active sites [active] 319795000796 tetramer interface [polypeptide binding]; other site 319795000797 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 319795000798 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 319795000799 catalytic triad [active] 319795000800 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 319795000801 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 319795000802 tetramer interface [polypeptide binding]; other site 319795000803 heme binding pocket [chemical binding]; other site 319795000804 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 319795000805 metal binding site 2 [ion binding]; metal-binding site 319795000806 putative DNA binding helix; other site 319795000807 metal binding site 1 [ion binding]; metal-binding site 319795000808 dimer interface [polypeptide binding]; other site 319795000809 structural Zn2+ binding site [ion binding]; other site 319795000810 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 319795000811 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 319795000812 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 319795000813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795000814 putative PBP binding loops; other site 319795000815 dimer interface [polypeptide binding]; other site 319795000816 ABC-ATPase subunit interface; other site 319795000817 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 319795000818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795000819 dimer interface [polypeptide binding]; other site 319795000820 conserved gate region; other site 319795000821 putative PBP binding loops; other site 319795000822 ABC-ATPase subunit interface; other site 319795000823 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 319795000824 putative substrate binding site [chemical binding]; other site 319795000825 active site 319795000826 Glycosyl hydrolase family 43; Region: GH43_bXyl_2; cd08991 319795000827 active site 319795000828 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795000829 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 319795000830 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795000831 DDE superfamily endonuclease; Region: DDE_4; pfam13359 319795000832 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 319795000833 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 319795000834 putative active site [active] 319795000835 Probable transposase; Region: OrfB_IS605; pfam01385 319795000836 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 319795000837 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14855 319795000838 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 319795000839 Transcriptional regulator [Transcription]; Region: LysR; COG0583 319795000840 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 319795000841 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 319795000842 dimerization interface [polypeptide binding]; other site 319795000843 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 319795000844 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 319795000845 NAD(P) binding site [chemical binding]; other site 319795000846 catalytic residues [active] 319795000847 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 319795000848 Walker A/P-loop; other site 319795000849 ATP binding site [chemical binding]; other site 319795000850 ABC transporter; Region: ABC_tran; pfam00005 319795000851 Q-loop/lid; other site 319795000852 ABC transporter signature motif; other site 319795000853 Walker B; other site 319795000854 D-loop; other site 319795000855 H-loop/switch region; other site 319795000856 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 319795000857 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 319795000858 Walker A/P-loop; other site 319795000859 ATP binding site [chemical binding]; other site 319795000860 Q-loop/lid; other site 319795000861 ABC transporter signature motif; other site 319795000862 Walker B; other site 319795000863 D-loop; other site 319795000864 H-loop/switch region; other site 319795000865 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 319795000866 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 319795000867 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 319795000868 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 319795000869 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 319795000870 Walker A/P-loop; other site 319795000871 ATP binding site [chemical binding]; other site 319795000872 Q-loop/lid; other site 319795000873 ABC transporter signature motif; other site 319795000874 Walker B; other site 319795000875 D-loop; other site 319795000876 H-loop/switch region; other site 319795000877 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172 319795000878 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 319795000879 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 319795000880 TM-ABC transporter signature motif; other site 319795000881 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 319795000882 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 319795000883 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 319795000884 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 319795000885 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 319795000886 Transcriptional regulators [Transcription]; Region: PurR; COG1609 319795000887 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 319795000888 DNA binding site [nucleotide binding] 319795000889 domain linker motif; other site 319795000890 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 319795000891 putative dimerization interface [polypeptide binding]; other site 319795000892 putative ligand binding site [chemical binding]; other site 319795000893 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 319795000894 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 319795000895 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795000896 dimer interface [polypeptide binding]; other site 319795000897 conserved gate region; other site 319795000898 putative PBP binding loops; other site 319795000899 ABC-ATPase subunit interface; other site 319795000900 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 319795000901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795000902 dimer interface [polypeptide binding]; other site 319795000903 conserved gate region; other site 319795000904 putative PBP binding loops; other site 319795000905 ABC-ATPase subunit interface; other site 319795000906 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 319795000907 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 319795000908 xylose isomerase; Provisional; Region: PRK12677 319795000909 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 319795000910 N- and C-terminal domain interface [polypeptide binding]; other site 319795000911 D-xylulose kinase; Region: XylB; TIGR01312 319795000912 active site 319795000913 MgATP binding site [chemical binding]; other site 319795000914 catalytic site [active] 319795000915 metal binding site [ion binding]; metal-binding site 319795000916 xylulose binding site [chemical binding]; other site 319795000917 homodimer interface [polypeptide binding]; other site 319795000918 Glycosyl hydrolase family 52; Region: Glyco_hydro_52; pfam03512 319795000919 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 319795000920 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 319795000921 catalytic tetrad [active] 319795000922 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 319795000923 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 319795000924 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 319795000925 MarR family; Region: MarR_2; pfam12802 319795000926 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 319795000927 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 319795000928 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 319795000929 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 319795000930 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 319795000931 active site residue [active] 319795000932 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 319795000933 active site residue [active] 319795000934 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 319795000935 Predicted transporter component [General function prediction only]; Region: COG2391 319795000936 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 319795000937 Predicted transporter component [General function prediction only]; Region: COG2391 319795000938 Sulphur transport; Region: Sulf_transp; pfam04143 319795000939 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 319795000940 putative homotetramer interface [polypeptide binding]; other site 319795000941 putative homodimer interface [polypeptide binding]; other site 319795000942 putative allosteric switch controlling residues; other site 319795000943 putative metal binding site [ion binding]; other site 319795000944 putative homodimer-homodimer interface [polypeptide binding]; other site 319795000945 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 319795000946 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 319795000947 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 319795000948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 319795000949 putative substrate translocation pore; other site 319795000950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 319795000951 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 319795000952 FOG: WD40 repeat [General function prediction only]; Region: COG2319 319795000953 structural tetrad; other site 319795000954 This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins; Region: NPCBM; smart00776 319795000955 This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins; Region: NPCBM; smart00776 319795000956 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 319795000957 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 319795000958 Bacterial Ig-like domain; Region: Big_5; pfam13205 319795000959 Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022 319795000960 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 319795000961 Bacterial sugar transferase; Region: Bac_transf; pfam02397 319795000962 This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins; Region: NPCBM; smart00776 319795000963 Kelch domain; Region: Kelch; smart00612 319795000964 Kelch motif; Region: Kelch_1; pfam01344 319795000965 Kelch motif; Region: Kelch_1; pfam01344 319795000966 Kelch motif; Region: Kelch_6; pfam13964 319795000967 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 319795000968 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 319795000969 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 319795000970 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 319795000971 O-Antigen ligase; Region: Wzy_C; pfam04932 319795000972 This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins; Region: NPCBM; smart00776 319795000973 This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins; Region: NPCBM; smart00776 319795000974 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 319795000975 This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins; Region: NPCBM; smart00776 319795000976 This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins; Region: NPCBM; smart00776 319795000977 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 319795000978 Kelch motif; Region: Kelch_1; pfam01344 319795000979 Kelch motif; Region: Kelch_6; pfam13964 319795000980 Kelch motif; Region: Kelch_1; pfam01344 319795000981 Kelch motif; Region: Kelch_6; pfam13964 319795000982 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 319795000983 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795000984 dimer interface [polypeptide binding]; other site 319795000985 conserved gate region; other site 319795000986 putative PBP binding loops; other site 319795000987 ABC-ATPase subunit interface; other site 319795000988 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 319795000989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795000990 ABC-ATPase subunit interface; other site 319795000991 putative PBP binding loops; other site 319795000992 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 319795000993 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 319795000994 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 319795000995 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 319795000996 active site 319795000997 catalytic site [active] 319795000998 metal binding site [ion binding]; metal-binding site 319795000999 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795001000 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 319795001001 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844 319795001002 putative ADP-binding pocket [chemical binding]; other site 319795001003 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 319795001004 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 319795001005 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 319795001006 putative ADP-binding pocket [chemical binding]; other site 319795001007 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 319795001008 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 319795001009 active site 319795001010 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 319795001011 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 319795001012 active site 319795001013 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 319795001014 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 319795001015 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 319795001016 Probable Catalytic site; other site 319795001017 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 319795001018 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 319795001019 NAD binding site [chemical binding]; other site 319795001020 putative substrate binding site 2 [chemical binding]; other site 319795001021 putative substrate binding site 1 [chemical binding]; other site 319795001022 active site 319795001023 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 319795001024 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 319795001025 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 319795001026 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 319795001027 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 319795001028 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 319795001029 NADP binding site [chemical binding]; other site 319795001030 active site 319795001031 putative substrate binding site [chemical binding]; other site 319795001032 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 319795001033 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 319795001034 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 319795001035 NAD binding site [chemical binding]; other site 319795001036 homotetramer interface [polypeptide binding]; other site 319795001037 homodimer interface [polypeptide binding]; other site 319795001038 active site 319795001039 substrate binding site [chemical binding]; other site 319795001040 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 319795001041 This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins; Region: NPCBM; smart00776 319795001042 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 319795001043 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 319795001044 substrate binding site; other site 319795001045 metal-binding site 319795001046 Oligomer interface; other site 319795001047 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 319795001048 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 319795001049 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 319795001050 G3 box; other site 319795001051 Switch II region; other site 319795001052 enterobactin exporter EntS; Provisional; Region: PRK10489 319795001053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 319795001054 putative substrate translocation pore; other site 319795001055 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 319795001056 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 319795001057 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 319795001058 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 319795001059 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 319795001060 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 319795001061 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 319795001062 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 319795001063 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 319795001064 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 319795001065 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 319795001066 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 319795001067 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 319795001068 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 319795001069 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 319795001070 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 319795001071 active site 319795001072 dimer interface [polypeptide binding]; other site 319795001073 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 319795001074 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 319795001075 active site 319795001076 FMN binding site [chemical binding]; other site 319795001077 substrate binding site [chemical binding]; other site 319795001078 3Fe-4S cluster binding site [ion binding]; other site 319795001079 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 319795001080 domain interface; other site 319795001081 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 319795001082 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 319795001083 dimer interface [polypeptide binding]; other site 319795001084 active site 319795001085 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 319795001086 dimer interface [polypeptide binding]; other site 319795001087 active site 319795001088 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 319795001089 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 319795001090 active site 319795001091 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 319795001092 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 319795001093 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 319795001094 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 319795001095 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 319795001096 dimerization domain swap beta strand [polypeptide binding]; other site 319795001097 regulatory protein interface [polypeptide binding]; other site 319795001098 active site 319795001099 regulatory phosphorylation site [posttranslational modification]; other site 319795001100 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 319795001101 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 319795001102 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 319795001103 active site turn [active] 319795001104 phosphorylation site [posttranslational modification] 319795001105 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 319795001106 HPr interaction site; other site 319795001107 glycerol kinase (GK) interaction site [polypeptide binding]; other site 319795001108 active site 319795001109 phosphorylation site [posttranslational modification] 319795001110 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 319795001111 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 319795001112 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 319795001113 putative active site [active] 319795001114 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 319795001115 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 319795001116 active site 319795001117 motif I; other site 319795001118 motif II; other site 319795001119 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 319795001120 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 319795001121 Transcriptional regulator [Transcription]; Region: IclR; COG1414 319795001122 Bacterial transcriptional regulator; Region: IclR; pfam01614 319795001123 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 319795001124 malate synthase A; Region: malate_syn_A; TIGR01344 319795001125 active site 319795001126 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 319795001127 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 319795001128 MOFRL family; Region: MOFRL; pfam05161 319795001129 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 319795001130 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 319795001131 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 319795001132 glyoxylate carboligase; Provisional; Region: PRK11269 319795001133 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 319795001134 PYR/PP interface [polypeptide binding]; other site 319795001135 dimer interface [polypeptide binding]; other site 319795001136 TPP binding site [chemical binding]; other site 319795001137 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 319795001138 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 319795001139 TPP-binding site [chemical binding]; other site 319795001140 malate synthase; Validated; Region: PRK09255 319795001141 malate synthase A; Region: malate_syn_A; TIGR01344 319795001142 active site 319795001143 allantoate amidohydrolase; Reviewed; Region: PRK09290 319795001144 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 319795001145 active site 319795001146 metal binding site [ion binding]; metal-binding site 319795001147 dimer interface [polypeptide binding]; other site 319795001148 allantoinase; Provisional; Region: PRK06189 319795001149 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 319795001150 active site 319795001151 hypothetical protein; Provisional; Region: PRK11171 319795001152 Cupin domain; Region: Cupin_2; cl17218 319795001153 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 319795001154 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 319795001155 guanine deaminase; Provisional; Region: PRK09228 319795001156 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 319795001157 active site 319795001158 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 319795001159 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 319795001160 XdhC Rossmann domain; Region: XdhC_C; pfam13478 319795001161 Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631 319795001162 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 319795001163 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 319795001164 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630 319795001165 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 319795001166 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 319795001167 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 319795001168 active site 319795001169 homotetramer interface [polypeptide binding]; other site 319795001170 urate oxidase; Region: urate_oxi; TIGR03383 319795001171 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 319795001172 active site 319795001173 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 319795001174 xanthine permease; Region: pbuX; TIGR03173 319795001175 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 319795001176 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 319795001177 DNA binding site [nucleotide binding] 319795001178 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 319795001179 dimerization interface [polypeptide binding]; other site 319795001180 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 319795001181 dimer interface [polypeptide binding]; other site 319795001182 phosphorylation site [posttranslational modification] 319795001183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 319795001184 ATP binding site [chemical binding]; other site 319795001185 Mg2+ binding site [ion binding]; other site 319795001186 G-X-G motif; other site 319795001187 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 319795001188 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 319795001189 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 319795001190 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 319795001191 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 319795001192 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 319795001193 metal-binding site [ion binding] 319795001194 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 319795001195 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 319795001196 metal-binding site [ion binding] 319795001197 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 319795001198 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 319795001199 motif II; other site 319795001200 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 319795001201 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 319795001202 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 319795001203 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 319795001204 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 319795001205 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 319795001206 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 319795001207 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 319795001208 Transposase; Region: HTH_Tnp_1; pfam01527 319795001209 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 319795001210 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 319795001211 putative DNA binding site [nucleotide binding]; other site 319795001212 dimerization interface [polypeptide binding]; other site 319795001213 putative Zn2+ binding site [ion binding]; other site 319795001214 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 319795001215 catalytic residues [active] 319795001216 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 319795001217 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 319795001218 metal-binding site [ion binding] 319795001219 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 319795001220 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 319795001221 metal-binding site [ion binding] 319795001222 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 319795001223 Soluble P-type ATPase [General function prediction only]; Region: COG4087 319795001224 lipoprotein signal peptidase; Provisional; Region: PRK14777 319795001225 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 319795001226 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 319795001227 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 319795001228 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 319795001229 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 319795001230 motif II; other site 319795001231 BON domain; Region: BON; pfam04972 319795001232 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 319795001233 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 319795001234 active site 319795001235 SUMO-1 interface [polypeptide binding]; other site 319795001236 Domain of unknown function (DUF305); Region: DUF305; pfam03713 319795001237 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 319795001238 dimerization interface [polypeptide binding]; other site 319795001239 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 319795001240 dimerization interface [polypeptide binding]; other site 319795001241 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 319795001242 dimer interface [polypeptide binding]; other site 319795001243 phosphorylation site [posttranslational modification] 319795001244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 319795001245 ATP binding site [chemical binding]; other site 319795001246 Mg2+ binding site [ion binding]; other site 319795001247 G-X-G motif; other site 319795001248 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 319795001249 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 319795001250 active site 319795001251 phosphorylation site [posttranslational modification] 319795001252 intermolecular recognition site; other site 319795001253 dimerization interface [polypeptide binding]; other site 319795001254 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 319795001255 DNA binding site [nucleotide binding] 319795001256 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 319795001257 putative active site [active] 319795001258 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 319795001259 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 319795001260 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 319795001261 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 319795001262 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 319795001263 putative homodimer interface [polypeptide binding]; other site 319795001264 putative homotetramer interface [polypeptide binding]; other site 319795001265 allosteric switch controlling residues; other site 319795001266 putative metal binding site [ion binding]; other site 319795001267 putative homodimer-homodimer interface [polypeptide binding]; other site 319795001268 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 319795001269 putative homodimer interface [polypeptide binding]; other site 319795001270 putative homotetramer interface [polypeptide binding]; other site 319795001271 allosteric switch controlling residues; other site 319795001272 putative metal binding site [ion binding]; other site 319795001273 putative homodimer-homodimer interface [polypeptide binding]; other site 319795001274 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 319795001275 metal-binding site [ion binding] 319795001276 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 319795001277 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 319795001278 metal-binding site [ion binding] 319795001279 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 319795001280 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 319795001281 metal-binding site [ion binding] 319795001282 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 319795001283 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 319795001284 motif II; other site 319795001285 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 319795001286 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 319795001287 dimerization interface [polypeptide binding]; other site 319795001288 putative DNA binding site [nucleotide binding]; other site 319795001289 putative Zn2+ binding site [ion binding]; other site 319795001290 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 319795001291 Low molecular weight phosphatase family; Region: LMWPc; cd00115 319795001292 active site 319795001293 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 319795001294 arsenical pump membrane protein; Provisional; Region: PRK15445 319795001295 transmembrane helices; other site 319795001296 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 319795001297 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 319795001298 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 319795001299 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 319795001300 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 319795001301 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 319795001302 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 319795001303 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 319795001304 active site 319795001305 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 319795001306 Walker A/P-loop; other site 319795001307 ATP binding site [chemical binding]; other site 319795001308 ABC transporter; Region: ABC_tran; pfam00005 319795001309 Q-loop/lid; other site 319795001310 ABC transporter signature motif; other site 319795001311 Walker B; other site 319795001312 D-loop; other site 319795001313 H-loop/switch region; other site 319795001314 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 319795001315 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 319795001316 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 319795001317 DNA-binding interface [nucleotide binding]; DNA binding site 319795001318 Integrase core domain; Region: rve; pfam00665 319795001319 transposase/IS protein; Provisional; Region: PRK09183 319795001320 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 319795001321 Walker A motif; other site 319795001322 ATP binding site [chemical binding]; other site 319795001323 Walker B motif; other site 319795001324 Predicted membrane protein [Function unknown]; Region: COG2323 319795001325 Phosphoesterase family; Region: Phosphoesterase; pfam04185 319795001326 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 319795001327 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 319795001328 MarR family; Region: MarR_2; pfam12802 319795001329 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 319795001330 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 319795001331 UDP-galactopyranose mutase; Region: GLF; pfam03275 319795001332 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 319795001333 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 319795001334 putative homodimer interface [polypeptide binding]; other site 319795001335 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 319795001336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 319795001337 active site 319795001338 phosphorylation site [posttranslational modification] 319795001339 intermolecular recognition site; other site 319795001340 dimerization interface [polypeptide binding]; other site 319795001341 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 319795001342 putative active site [active] 319795001343 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 319795001344 GAF domain; Region: GAF_3; pfam13492 319795001345 GAF domain; Region: GAF_3; pfam13492 319795001346 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 319795001347 dimer interface [polypeptide binding]; other site 319795001348 phosphorylation site [posttranslational modification] 319795001349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 319795001350 ATP binding site [chemical binding]; other site 319795001351 Mg2+ binding site [ion binding]; other site 319795001352 G-X-G motif; other site 319795001353 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 319795001354 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 319795001355 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 319795001356 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 319795001357 amphipathic channel; other site 319795001358 Asn-Pro-Ala signature motifs; other site 319795001359 glycerol kinase; Provisional; Region: glpK; PRK00047 319795001360 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 319795001361 N- and C-terminal domain interface [polypeptide binding]; other site 319795001362 active site 319795001363 MgATP binding site [chemical binding]; other site 319795001364 catalytic site [active] 319795001365 metal binding site [ion binding]; metal-binding site 319795001366 glycerol binding site [chemical binding]; other site 319795001367 homotetramer interface [polypeptide binding]; other site 319795001368 homodimer interface [polypeptide binding]; other site 319795001369 FBP binding site [chemical binding]; other site 319795001370 protein IIAGlc interface [polypeptide binding]; other site 319795001371 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 319795001372 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 319795001373 Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism; Region: HOT; cd08190 319795001374 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 319795001375 putative active site [active] 319795001376 metal binding site [ion binding]; metal-binding site 319795001377 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 319795001378 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 319795001379 Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935 319795001380 acyl-activating enzyme (AAE) consensus motif; other site 319795001381 putative AMP binding site [chemical binding]; other site 319795001382 putative active site [active] 319795001383 putative CoA binding site [chemical binding]; other site 319795001384 thioredoxin 2; Provisional; Region: PRK10996 319795001385 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 319795001386 catalytic residues [active] 319795001387 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 319795001388 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 319795001389 catalytic core [active] 319795001390 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 319795001391 catalytic core [active] 319795001392 Predicted transcriptional regulator [Transcription]; Region: COG2378 319795001393 HTH domain; Region: HTH_11; pfam08279 319795001394 WYL domain; Region: WYL; pfam13280 319795001395 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 319795001396 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 319795001397 binding surface 319795001398 TPR motif; other site 319795001399 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 319795001400 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 319795001401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795001402 dimer interface [polypeptide binding]; other site 319795001403 conserved gate region; other site 319795001404 putative PBP binding loops; other site 319795001405 ABC-ATPase subunit interface; other site 319795001406 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 319795001407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795001408 dimer interface [polypeptide binding]; other site 319795001409 conserved gate region; other site 319795001410 putative PBP binding loops; other site 319795001411 ABC-ATPase subunit interface; other site 319795001412 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 319795001413 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 319795001414 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 319795001415 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 319795001416 DNA-binding site [nucleotide binding]; DNA binding site 319795001417 UTRA domain; Region: UTRA; pfam07702 319795001418 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 319795001419 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 319795001420 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 319795001421 putative active site [active] 319795001422 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 319795001423 Beta-lactamase; Region: Beta-lactamase; pfam00144 319795001424 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 319795001425 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 319795001426 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 319795001427 substrate binding site [chemical binding]; other site 319795001428 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 319795001429 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 319795001430 active site 319795001431 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 319795001432 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 319795001433 IHF - DNA interface [nucleotide binding]; other site 319795001434 IHF dimer interface [polypeptide binding]; other site 319795001435 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 319795001436 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 319795001437 NAD(P) binding site [chemical binding]; other site 319795001438 catalytic residues [active] 319795001439 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 319795001440 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 319795001441 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 319795001442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795001443 dimer interface [polypeptide binding]; other site 319795001444 conserved gate region; other site 319795001445 putative PBP binding loops; other site 319795001446 ABC-ATPase subunit interface; other site 319795001447 Replication initiator protein A; Region: RPA; cl17860 319795001448 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 319795001449 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 319795001450 P-loop; other site 319795001451 Magnesium ion binding site [ion binding]; other site 319795001452 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 319795001453 ParB-like nuclease domain; Region: ParBc; pfam02195 319795001454 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 319795001455 DinB superfamily; Region: DinB_2; pfam12867 319795001456 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 319795001457 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 319795001458 Histidine kinase; Region: HisKA_3; pfam07730 319795001459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 319795001460 ATP binding site [chemical binding]; other site 319795001461 Mg2+ binding site [ion binding]; other site 319795001462 G-X-G motif; other site 319795001463 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 319795001464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 319795001465 active site 319795001466 phosphorylation site [posttranslational modification] 319795001467 intermolecular recognition site; other site 319795001468 dimerization interface [polypeptide binding]; other site 319795001469 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 319795001470 DNA binding residues [nucleotide binding] 319795001471 dimerization interface [polypeptide binding]; other site 319795001472 Phosphotransferase enzyme family; Region: APH; pfam01636 319795001473 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 319795001474 active site 319795001475 ATP binding site [chemical binding]; other site 319795001476 substrate binding site [chemical binding]; other site 319795001477 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 319795001478 putative catalytic site [active] 319795001479 putative phosphate binding site [ion binding]; other site 319795001480 active site 319795001481 metal binding site A [ion binding]; metal-binding site 319795001482 DNA binding site [nucleotide binding] 319795001483 putative AP binding site [nucleotide binding]; other site 319795001484 putative metal binding site B [ion binding]; other site 319795001485 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 319795001486 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 319795001487 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 319795001488 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 319795001489 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 319795001490 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 319795001491 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 319795001492 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 319795001493 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 319795001494 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 319795001495 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 319795001496 nucleotide binding site/active site [active] 319795001497 HIT family signature motif; other site 319795001498 catalytic residue [active] 319795001499 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 319795001500 GAF domain; Region: GAF; pfam01590 319795001501 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 319795001502 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 319795001503 metal binding site [ion binding]; metal-binding site 319795001504 active site 319795001505 I-site; other site 319795001506 DnaA N-terminal domain; Region: DnaA_N; pfam11638 319795001507 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 319795001508 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 319795001509 Walker A motif; other site 319795001510 ATP binding site [chemical binding]; other site 319795001511 Walker B motif; other site 319795001512 arginine finger; other site 319795001513 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 319795001514 DnaA box-binding interface [nucleotide binding]; other site 319795001515 DNA polymerase III subunit beta; Provisional; Region: PRK14945 319795001516 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 319795001517 putative DNA binding surface [nucleotide binding]; other site 319795001518 dimer interface [polypeptide binding]; other site 319795001519 beta-clamp/clamp loader binding surface; other site 319795001520 beta-clamp/translesion DNA polymerase binding surface; other site 319795001521 enolase; Provisional; Region: eno; PRK00077 319795001522 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 319795001523 dimer interface [polypeptide binding]; other site 319795001524 metal binding site [ion binding]; metal-binding site 319795001525 substrate binding pocket [chemical binding]; other site 319795001526 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 319795001527 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 319795001528 domain interfaces; other site 319795001529 active site 319795001530 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 319795001531 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 319795001532 active site 319795001533 HIGH motif; other site 319795001534 dimer interface [polypeptide binding]; other site 319795001535 KMSKS motif; other site 319795001536 MOSC domain; Region: MOSC; pfam03473 319795001537 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 319795001538 Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350 319795001539 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 319795001540 Family of unknown function (DUF633); Region: DUF633; pfam04816 319795001541 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 319795001542 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 319795001543 glutaminase active site [active] 319795001544 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 319795001545 dimer interface [polypeptide binding]; other site 319795001546 active site 319795001547 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 319795001548 dimer interface [polypeptide binding]; other site 319795001549 active site 319795001550 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 319795001551 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 319795001552 homodimer interface [polypeptide binding]; other site 319795001553 substrate-cofactor binding pocket; other site 319795001554 pyridoxal 5'-phosphate binding site [chemical binding]; other site 319795001555 catalytic residue [active] 319795001556 Predicted membrane protein [Function unknown]; Region: COG2860 319795001557 UPF0126 domain; Region: UPF0126; pfam03458 319795001558 UPF0126 domain; Region: UPF0126; pfam03458 319795001559 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 319795001560 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 319795001561 Bacterial transcriptional activator domain; Region: BTAD; smart01043 319795001562 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 319795001563 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 319795001564 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 319795001565 ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660 319795001566 Putative D-pathway homolog; other site 319795001567 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 319795001568 Low-spin heme binding site [chemical binding]; other site 319795001569 Subunit I/II interface [polypeptide binding]; other site 319795001570 Putative Q-pathway; other site 319795001571 Putative alternate electron transfer pathway; other site 319795001572 Putative water exit pathway; other site 319795001573 Binuclear center (active site) [active] 319795001574 Putative K-pathway homolog; other site 319795001575 Putative proton exit pathway; other site 319795001576 Subunit I/IIa interface [polypeptide binding]; other site 319795001577 Electron transfer pathway; other site 319795001578 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 319795001579 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 319795001580 minor groove reading motif; other site 319795001581 helix-hairpin-helix signature motif; other site 319795001582 substrate binding pocket [chemical binding]; other site 319795001583 active site 319795001584 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 319795001585 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 319795001586 DNA binding and oxoG recognition site [nucleotide binding] 319795001587 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14835 319795001588 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 319795001589 catalytic residue [active] 319795001590 putative FPP diphosphate binding site; other site 319795001591 putative FPP binding hydrophobic cleft; other site 319795001592 dimer interface [polypeptide binding]; other site 319795001593 putative IPP diphosphate binding site; other site 319795001594 HRDC domain; Region: HRDC; pfam00570 319795001595 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 319795001596 dimer interface [polypeptide binding]; other site 319795001597 [2Fe-2S] cluster binding site [ion binding]; other site 319795001598 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 319795001599 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 319795001600 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 319795001601 Walker A/P-loop; other site 319795001602 ATP binding site [chemical binding]; other site 319795001603 Q-loop/lid; other site 319795001604 ABC transporter signature motif; other site 319795001605 Walker B; other site 319795001606 D-loop; other site 319795001607 H-loop/switch region; other site 319795001608 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 319795001609 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 319795001610 ABC-ATPase subunit interface; other site 319795001611 dimer interface [polypeptide binding]; other site 319795001612 putative PBP binding regions; other site 319795001613 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 319795001614 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 319795001615 putative binding site residues; other site 319795001616 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 319795001617 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 319795001618 putative acyl-acceptor binding pocket; other site 319795001619 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 319795001620 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3877 319795001621 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 319795001622 RNB domain; Region: RNB; pfam00773 319795001623 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 319795001624 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 319795001625 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 319795001626 Coenzyme A binding pocket [chemical binding]; other site 319795001627 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 319795001628 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 319795001629 putative active site; other site 319795001630 catalytic triad [active] 319795001631 putative dimer interface [polypeptide binding]; other site 319795001632 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 319795001633 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 319795001634 dimerization interface 3.5A [polypeptide binding]; other site 319795001635 active site 319795001636 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 319795001637 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 319795001638 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 319795001639 Peptidase family M23; Region: Peptidase_M23; pfam01551 319795001640 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 319795001641 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 319795001642 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 319795001643 NAD binding site [chemical binding]; other site 319795001644 catalytic Zn binding site [ion binding]; other site 319795001645 structural Zn binding site [ion binding]; other site 319795001646 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 319795001647 putative hydrophobic ligand binding site [chemical binding]; other site 319795001648 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 319795001649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 319795001650 active site 319795001651 phosphorylation site [posttranslational modification] 319795001652 intermolecular recognition site; other site 319795001653 dimerization interface [polypeptide binding]; other site 319795001654 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 319795001655 Predicted membrane protein [Function unknown]; Region: COG2862 319795001656 Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955 319795001657 NodB motif; other site 319795001658 putative active site [active] 319795001659 putative catalytic site [active] 319795001660 Predicted permeases [General function prediction only]; Region: COG0795 319795001661 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 319795001662 Predicted permeases [General function prediction only]; Region: COG0795 319795001663 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 319795001664 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 319795001665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 319795001666 S-adenosylmethionine binding site [chemical binding]; other site 319795001667 phosphate acetyltransferase; Reviewed; Region: PRK05632 319795001668 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 319795001669 DRTGG domain; Region: DRTGG; pfam07085 319795001670 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 319795001671 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 319795001672 propionate/acetate kinase; Provisional; Region: PRK12379 319795001673 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 319795001674 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 319795001675 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 319795001676 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 319795001677 substrate-cofactor binding pocket; other site 319795001678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 319795001679 catalytic residue [active] 319795001680 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 319795001681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 319795001682 S-adenosylmethionine binding site [chemical binding]; other site 319795001683 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 319795001684 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 319795001685 active site 319795001686 homotetramer interface [polypeptide binding]; other site 319795001687 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 319795001688 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 319795001689 active site 319795001690 motif I; other site 319795001691 motif II; other site 319795001692 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 319795001693 catalytic core [active] 319795001694 amidophosphoribosyltransferase; Region: purF; TIGR01134 319795001695 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 319795001696 active site 319795001697 tetramer interface [polypeptide binding]; other site 319795001698 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 319795001699 active site 319795001700 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 319795001701 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 319795001702 dimerization interface [polypeptide binding]; other site 319795001703 ATP binding site [chemical binding]; other site 319795001704 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 319795001705 dimerization interface [polypeptide binding]; other site 319795001706 ATP binding site [chemical binding]; other site 319795001707 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 319795001708 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 319795001709 putative active site [active] 319795001710 catalytic triad [active] 319795001711 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 319795001712 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 319795001713 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 319795001714 active site 319795001715 ATP binding site [chemical binding]; other site 319795001716 substrate binding site [chemical binding]; other site 319795001717 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 319795001718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 319795001719 S-adenosylmethionine binding site [chemical binding]; other site 319795001720 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 319795001721 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 319795001722 G-X-X-G motif; other site 319795001723 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 319795001724 RxxxH motif; other site 319795001725 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 319795001726 active site 319795001727 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 319795001728 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 319795001729 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 319795001730 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 319795001731 homotrimer interaction site [polypeptide binding]; other site 319795001732 zinc binding site [ion binding]; other site 319795001733 CDP-binding sites; other site 319795001734 Uncharacterized conserved protein [Function unknown]; Region: COG1739 319795001735 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 319795001736 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 319795001737 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 319795001738 dimer interface [polypeptide binding]; other site 319795001739 ADP-ribose binding site [chemical binding]; other site 319795001740 active site 319795001741 nudix motif; other site 319795001742 metal binding site [ion binding]; metal-binding site 319795001743 DinB family; Region: DinB; pfam05163 319795001744 DinB superfamily; Region: DinB_2; pfam12867 319795001745 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 319795001746 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 319795001747 FMN binding site [chemical binding]; other site 319795001748 active site 319795001749 catalytic residues [active] 319795001750 substrate binding site [chemical binding]; other site 319795001751 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 319795001752 Coenzyme A binding pocket [chemical binding]; other site 319795001753 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 319795001754 nucleotide binding site [chemical binding]; other site 319795001755 N-acetyl-L-glutamate binding site [chemical binding]; other site 319795001756 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 319795001757 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 319795001758 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 319795001759 ATP-grasp domain; Region: ATP-grasp; pfam02222 319795001760 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 319795001761 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 319795001762 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 319795001763 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 319795001764 dimerization interface [polypeptide binding]; other site 319795001765 Domain of unknown function (DUF305); Region: DUF305; pfam03713 319795001766 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 319795001767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 319795001768 active site 319795001769 phosphorylation site [posttranslational modification] 319795001770 intermolecular recognition site; other site 319795001771 dimerization interface [polypeptide binding]; other site 319795001772 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 319795001773 DNA binding site [nucleotide binding] 319795001774 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 319795001775 dimerization interface [polypeptide binding]; other site 319795001776 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 319795001777 dimer interface [polypeptide binding]; other site 319795001778 phosphorylation site [posttranslational modification] 319795001779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 319795001780 ATP binding site [chemical binding]; other site 319795001781 Mg2+ binding site [ion binding]; other site 319795001782 G-X-G motif; other site 319795001783 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 319795001784 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 319795001785 metal-binding site [ion binding] 319795001786 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 319795001787 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 319795001788 metal-binding site [ion binding] 319795001789 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 319795001790 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 319795001791 motif II; other site 319795001792 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 319795001793 metal-binding site [ion binding] 319795001794 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 319795001795 putative homodimer interface [polypeptide binding]; other site 319795001796 putative homotetramer interface [polypeptide binding]; other site 319795001797 allosteric switch controlling residues; other site 319795001798 putative metal binding site [ion binding]; other site 319795001799 putative homodimer-homodimer interface [polypeptide binding]; other site 319795001800 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 319795001801 Domain of unknown function DUF21; Region: DUF21; pfam01595 319795001802 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 319795001803 Transporter associated domain; Region: CorC_HlyC; smart01091 319795001804 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 319795001805 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 319795001806 domain interfaces; other site 319795001807 active site 319795001808 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 319795001809 active site 319795001810 homotetramer interface [polypeptide binding]; other site 319795001811 homodimer interface [polypeptide binding]; other site 319795001812 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 319795001813 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 319795001814 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 319795001815 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 319795001816 motif II; other site 319795001817 Ferritin-like domain; Region: Ferritin_2; pfam13668 319795001818 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 319795001819 classical (c) SDRs; Region: SDR_c; cd05233 319795001820 NAD(P) binding site [chemical binding]; other site 319795001821 active site 319795001822 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 319795001823 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 319795001824 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 319795001825 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 319795001826 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 319795001827 putative Zn2+ binding site [ion binding]; other site 319795001828 putative DNA binding site [nucleotide binding]; other site 319795001829 dimerization interface [polypeptide binding]; other site 319795001830 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 319795001831 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 319795001832 Substrate-binding site [chemical binding]; other site 319795001833 Substrate specificity [chemical binding]; other site 319795001834 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 319795001835 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 319795001836 Substrate-binding site [chemical binding]; other site 319795001837 Substrate specificity [chemical binding]; other site 319795001838 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 319795001839 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 319795001840 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 319795001841 protein binding site [polypeptide binding]; other site 319795001842 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 319795001843 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 319795001844 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 319795001845 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 319795001846 active site 319795001847 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 319795001848 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 319795001849 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 319795001850 ligand binding site [chemical binding]; other site 319795001851 flexible hinge region; other site 319795001852 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 319795001853 putative switch regulator; other site 319795001854 non-specific DNA interactions [nucleotide binding]; other site 319795001855 DNA binding site [nucleotide binding] 319795001856 sequence specific DNA binding site [nucleotide binding]; other site 319795001857 putative cAMP binding site [chemical binding]; other site 319795001858 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 319795001859 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 319795001860 minor groove reading motif; other site 319795001861 helix-hairpin-helix signature motif; other site 319795001862 active site 319795001863 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 319795001864 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 319795001865 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 319795001866 NAD(P) binding site [chemical binding]; other site 319795001867 active site 319795001868 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_37; cd04696 319795001869 nudix motif; other site 319795001870 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 319795001871 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 319795001872 Walker A/P-loop; other site 319795001873 ATP binding site [chemical binding]; other site 319795001874 Q-loop/lid; other site 319795001875 ABC transporter signature motif; other site 319795001876 Walker B; other site 319795001877 D-loop; other site 319795001878 H-loop/switch region; other site 319795001879 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 319795001880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795001881 dimer interface [polypeptide binding]; other site 319795001882 conserved gate region; other site 319795001883 ABC-ATPase subunit interface; other site 319795001884 EamA-like transporter family; Region: EamA; pfam00892 319795001885 EamA-like transporter family; Region: EamA; pfam00892 319795001886 Predicted integral membrane protein [Function unknown]; Region: COG5637 319795001887 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 319795001888 putative hydrophobic ligand binding site [chemical binding]; other site 319795001889 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 319795001890 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 319795001891 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 319795001892 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 319795001893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 319795001894 homodimer interface [polypeptide binding]; other site 319795001895 catalytic residue [active] 319795001896 Flagellin N-methylase; Region: FliB; cl00497 319795001897 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 319795001898 Chromate transporter; Region: Chromate_transp; pfam02417 319795001899 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 319795001900 dinuclear metal binding motif [ion binding]; other site 319795001901 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 319795001902 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 319795001903 dimer interface [polypeptide binding]; other site 319795001904 catalytic triad [active] 319795001905 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 319795001906 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 319795001907 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 319795001908 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 319795001909 ABC-ATPase subunit interface; other site 319795001910 dimer interface [polypeptide binding]; other site 319795001911 putative PBP binding regions; other site 319795001912 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 319795001913 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 319795001914 Walker A/P-loop; other site 319795001915 ATP binding site [chemical binding]; other site 319795001916 Q-loop/lid; other site 319795001917 ABC transporter signature motif; other site 319795001918 Walker B; other site 319795001919 D-loop; other site 319795001920 H-loop/switch region; other site 319795001921 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 319795001922 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 319795001923 FAD binding pocket [chemical binding]; other site 319795001924 FAD binding motif [chemical binding]; other site 319795001925 phosphate binding motif [ion binding]; other site 319795001926 NAD binding pocket [chemical binding]; other site 319795001927 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 319795001928 PhoU domain; Region: PhoU; pfam01895 319795001929 PhoU domain; Region: PhoU; pfam01895 319795001930 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 319795001931 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 319795001932 dimer interface [polypeptide binding]; other site 319795001933 phosphorylation site [posttranslational modification] 319795001934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 319795001935 ATP binding site [chemical binding]; other site 319795001936 Mg2+ binding site [ion binding]; other site 319795001937 G-X-G motif; other site 319795001938 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 319795001939 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 319795001940 active site 319795001941 phosphorylation site [posttranslational modification] 319795001942 intermolecular recognition site; other site 319795001943 dimerization interface [polypeptide binding]; other site 319795001944 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 319795001945 DNA binding site [nucleotide binding] 319795001946 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 319795001947 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 319795001948 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 319795001949 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 319795001950 Zn2+ binding site [ion binding]; other site 319795001951 Mg2+ binding site [ion binding]; other site 319795001952 YbbR-like protein; Region: YbbR; pfam07949 319795001953 Uncharacterized conserved protein [Function unknown]; Region: COG1624 319795001954 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 319795001955 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 319795001956 metal-dependent hydrolase; Provisional; Region: PRK00685 319795001957 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222 319795001958 RNA/DNA hybrid binding site [nucleotide binding]; other site 319795001959 active site 319795001960 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 319795001961 active site 319795001962 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 319795001963 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 319795001964 E3 interaction surface; other site 319795001965 lipoyl attachment site [posttranslational modification]; other site 319795001966 e3 binding domain; Region: E3_binding; pfam02817 319795001967 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 319795001968 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 319795001969 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 319795001970 TPP-binding site [chemical binding]; other site 319795001971 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 319795001972 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 319795001973 BON domain; Region: BON; pfam04972 319795001974 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 319795001975 Cytochrome P450; Region: p450; cl12078 319795001976 pyridoxamine kinase; Validated; Region: PRK05756 319795001977 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 319795001978 dimer interface [polypeptide binding]; other site 319795001979 pyridoxal binding site [chemical binding]; other site 319795001980 ATP binding site [chemical binding]; other site 319795001981 enoyl-CoA hydratase; Provisional; Region: PRK06142 319795001982 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 319795001983 substrate binding site [chemical binding]; other site 319795001984 oxyanion hole (OAH) forming residues; other site 319795001985 trimer interface [polypeptide binding]; other site 319795001986 short chain dehydrogenase; Provisional; Region: PRK07576 319795001987 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 319795001988 NAD(P) binding site [chemical binding]; other site 319795001989 substrate binding site [chemical binding]; other site 319795001990 homotetramer interface [polypeptide binding]; other site 319795001991 active site 319795001992 homodimer interface [polypeptide binding]; other site 319795001993 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 319795001994 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 319795001995 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 319795001996 generic binding surface II; other site 319795001997 generic binding surface I; other site 319795001998 Exonuclease VII, large subunit; Region: Exonuc_VII_L; pfam02601 319795001999 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 319795002000 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 319795002001 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 319795002002 oligomer interface [polypeptide binding]; other site 319795002003 metal binding site [ion binding]; metal-binding site 319795002004 metal binding site [ion binding]; metal-binding site 319795002005 putative Cl binding site [ion binding]; other site 319795002006 aspartate ring; other site 319795002007 basic sphincter; other site 319795002008 hydrophobic gate; other site 319795002009 periplasmic entrance; other site 319795002010 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 319795002011 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 319795002012 active site 319795002013 OstA-like protein; Region: OstA; cl00844 319795002014 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 319795002015 OstA-like protein; Region: OstA; cl00844 319795002016 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 319795002017 Ligand Binding Site [chemical binding]; other site 319795002018 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 319795002019 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 319795002020 Beta-Casp domain; Region: Beta-Casp; smart01027 319795002021 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 319795002022 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 319795002023 active site 319795002024 catalytic site [active] 319795002025 substrate binding site [chemical binding]; other site 319795002026 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 319795002027 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 319795002028 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 319795002029 active site residue [active] 319795002030 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 319795002031 active site residue [active] 319795002032 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 319795002033 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 319795002034 active site 319795002035 catalytic tetrad [active] 319795002036 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 319795002037 KH domain; Region: KH_1; pfam00013 319795002038 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 319795002039 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 319795002040 Zn2+ binding site [ion binding]; other site 319795002041 Mg2+ binding site [ion binding]; other site 319795002042 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 319795002043 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 319795002044 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 319795002045 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 319795002046 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 319795002047 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 319795002048 dimer interface [polypeptide binding]; other site 319795002049 ssDNA binding site [nucleotide binding]; other site 319795002050 tetramer (dimer of dimers) interface [polypeptide binding]; other site 319795002051 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 319795002052 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 319795002053 dimer interface [polypeptide binding]; other site 319795002054 ssDNA binding site [nucleotide binding]; other site 319795002055 tetramer (dimer of dimers) interface [polypeptide binding]; other site 319795002056 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 319795002057 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 319795002058 Catalytic domain of Protein Kinases; Region: PKc; cd00180 319795002059 active site 319795002060 ATP binding site [chemical binding]; other site 319795002061 substrate binding site [chemical binding]; other site 319795002062 activation loop (A-loop); other site 319795002063 peptide chain release factor 2; Validated; Region: prfB; PRK00578 319795002064 PCRF domain; Region: PCRF; pfam03462 319795002065 RF-1 domain; Region: RF-1; pfam00472 319795002066 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 319795002067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795002068 dimer interface [polypeptide binding]; other site 319795002069 conserved gate region; other site 319795002070 ABC-ATPase subunit interface; other site 319795002071 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 319795002072 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 319795002073 Walker A/P-loop; other site 319795002074 ATP binding site [chemical binding]; other site 319795002075 Q-loop/lid; other site 319795002076 ABC transporter signature motif; other site 319795002077 Walker B; other site 319795002078 D-loop; other site 319795002079 H-loop/switch region; other site 319795002080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795002081 ABC-ATPase subunit interface; other site 319795002082 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 319795002083 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 319795002084 IHF - DNA interface [nucleotide binding]; other site 319795002085 IHF dimer interface [polypeptide binding]; other site 319795002086 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 319795002087 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 319795002088 ATP binding site [chemical binding]; other site 319795002089 substrate interface [chemical binding]; other site 319795002090 membrane protein; Provisional; Region: PRK14401 319795002091 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 319795002092 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14612 319795002093 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 319795002094 substrate binding site; other site 319795002095 dimer interface; other site 319795002096 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 319795002097 Flavoprotein; Region: Flavoprotein; pfam02441 319795002098 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 319795002099 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 319795002100 active site 319795002101 phosphorylation site [posttranslational modification] 319795002102 intermolecular recognition site; other site 319795002103 dimerization interface [polypeptide binding]; other site 319795002104 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 319795002105 DNA binding residues [nucleotide binding] 319795002106 dimerization interface [polypeptide binding]; other site 319795002107 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 319795002108 Histidine kinase; Region: HisKA_3; pfam07730 319795002109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 319795002110 ATP binding site [chemical binding]; other site 319795002111 Mg2+ binding site [ion binding]; other site 319795002112 G-X-G motif; other site 319795002113 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 319795002114 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 319795002115 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 319795002116 Walker A/P-loop; other site 319795002117 ATP binding site [chemical binding]; other site 319795002118 Q-loop/lid; other site 319795002119 ABC transporter signature motif; other site 319795002120 Walker B; other site 319795002121 D-loop; other site 319795002122 H-loop/switch region; other site 319795002123 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 319795002124 Transcriptional regulator [Transcription]; Region: IclR; COG1414 319795002125 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 319795002126 Bacterial transcriptional regulator; Region: IclR; pfam01614 319795002127 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 319795002128 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 319795002129 substrate binding site; other site 319795002130 metal-binding site 319795002131 Oligomer interface; other site 319795002132 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 319795002133 N-terminal domain interface [polypeptide binding]; other site 319795002134 sulfate 1 binding site; other site 319795002135 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 319795002136 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 319795002137 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 319795002138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 319795002139 active site 319795002140 phosphorylation site [posttranslational modification] 319795002141 intermolecular recognition site; other site 319795002142 dimerization interface [polypeptide binding]; other site 319795002143 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 319795002144 DNA binding site [nucleotide binding] 319795002145 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 319795002146 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 319795002147 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 319795002148 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 319795002149 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 319795002150 CoenzymeA binding site [chemical binding]; other site 319795002151 subunit interaction site [polypeptide binding]; other site 319795002152 PHB binding site; other site 319795002153 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 319795002154 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 319795002155 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 319795002156 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 319795002157 ATP-binding site [chemical binding]; other site 319795002158 Sugar specificity; other site 319795002159 Pyrimidine base specificity; other site 319795002160 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 319795002161 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 319795002162 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 319795002163 NAD binding site [chemical binding]; other site 319795002164 Phe binding site; other site 319795002165 e3 binding domain; Region: E3_binding; pfam02817 319795002166 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 319795002167 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 319795002168 GDP-binding site [chemical binding]; other site 319795002169 ACT binding site; other site 319795002170 IMP binding site; other site 319795002171 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 319795002172 GTP cyclohydrolase I; Provisional; Region: PLN03044 319795002173 homodecamer interface [polypeptide binding]; other site 319795002174 active site 319795002175 putative catalytic site residues [active] 319795002176 zinc binding site [ion binding]; other site 319795002177 GTP-CH-I/GFRP interaction surface; other site 319795002178 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 319795002179 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 319795002180 trimerization site [polypeptide binding]; other site 319795002181 active site 319795002182 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 319795002183 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 319795002184 metal binding site [ion binding]; metal-binding site 319795002185 dimer interface [polypeptide binding]; other site 319795002186 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 319795002187 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 319795002188 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 319795002189 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 319795002190 MoxR-like ATPases [General function prediction only]; Region: COG0714 319795002191 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 319795002192 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 319795002193 putative hydrophobic ligand binding site [chemical binding]; other site 319795002194 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 319795002195 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 319795002196 Ligand binding site; other site 319795002197 metal-binding site 319795002198 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 319795002199 CHAD domain; Region: CHAD; pfam05235 319795002200 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 319795002201 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 319795002202 active site 319795002203 metal binding site [ion binding]; metal-binding site 319795002204 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 319795002205 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 319795002206 putative active site [active] 319795002207 putative metal binding site [ion binding]; other site 319795002208 GAF domain; Region: GAF; cl17456 319795002209 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 319795002210 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 319795002211 Zn2+ binding site [ion binding]; other site 319795002212 Mg2+ binding site [ion binding]; other site 319795002213 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 319795002214 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 319795002215 dimer interface [polypeptide binding]; other site 319795002216 active site 319795002217 glycine-pyridoxal phosphate binding site [chemical binding]; other site 319795002218 folate binding site [chemical binding]; other site 319795002219 potassium/proton antiporter; Reviewed; Region: PRK05326 319795002220 TrkA-C domain; Region: TrkA_C; pfam02080 319795002221 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 319795002222 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 319795002223 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 319795002224 dimer interface [polypeptide binding]; other site 319795002225 motif 1; other site 319795002226 active site 319795002227 motif 2; other site 319795002228 motif 3; other site 319795002229 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 319795002230 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 319795002231 putative tRNA-binding site [nucleotide binding]; other site 319795002232 B3/4 domain; Region: B3_4; pfam03483 319795002233 tRNA synthetase B5 domain; Region: B5; smart00874 319795002234 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 319795002235 dimer interface [polypeptide binding]; other site 319795002236 motif 1; other site 319795002237 motif 3; other site 319795002238 motif 2; other site 319795002239 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 319795002240 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 319795002241 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 319795002242 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 319795002243 catalytic residue [active] 319795002244 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 319795002245 catalytic triad [active] 319795002246 conserved cis-peptide bond; other site 319795002247 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 319795002248 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional proteins, also containing a Nudix hydrolase domain; Region: NMNAT_Nudix; cd02168 319795002249 active site 319795002250 (T/H)XGH motif; other site 319795002251 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 319795002252 nudix motif; other site 319795002253 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 319795002254 active site 319795002255 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 319795002256 homotrimer interaction site [polypeptide binding]; other site 319795002257 putative active site [active] 319795002258 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 319795002259 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 319795002260 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 319795002261 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 319795002262 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 319795002263 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 319795002264 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 319795002265 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 319795002266 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 319795002267 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 319795002268 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 319795002269 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 319795002270 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 319795002271 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 319795002272 active site 319795002273 dimer interfaces [polypeptide binding]; other site 319795002274 catalytic residues [active] 319795002275 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 319795002276 ROK family; Region: ROK; pfam00480 319795002277 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 319795002278 active site 319795002279 CutA1 divalent ion tolerance protein; Region: CutA1; pfam03091 319795002280 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 319795002281 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 319795002282 minor groove reading motif; other site 319795002283 helix-hairpin-helix signature motif; other site 319795002284 substrate binding pocket [chemical binding]; other site 319795002285 active site 319795002286 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 319795002287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 319795002288 putative substrate translocation pore; other site 319795002289 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 319795002290 Putative zinc ribbon domain; Region: DUF164; pfam02591 319795002291 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 319795002292 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 319795002293 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 319795002294 effector binding site; other site 319795002295 dimer interface [polypeptide binding]; other site 319795002296 active site 319795002297 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 319795002298 TSCPD domain; Region: TSCPD; pfam12637 319795002299 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 319795002300 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 319795002301 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 319795002302 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 319795002303 active site 319795002304 metal binding site [ion binding]; metal-binding site 319795002305 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 319795002306 PHP domain; Region: PHP; pfam02811 319795002307 active site 319795002308 PHP Thumb interface [polypeptide binding]; other site 319795002309 metal binding site [ion binding]; metal-binding site 319795002310 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 319795002311 DNA polymerase III subunit alpha; Reviewed; Region: PRK07373 319795002312 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 319795002313 generic binding surface II; other site 319795002314 generic binding surface I; other site 319795002315 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 319795002316 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 319795002317 Walker A motif; other site 319795002318 ATP binding site [chemical binding]; other site 319795002319 Walker B motif; other site 319795002320 DinB superfamily; Region: DinB_2; pfam12867 319795002321 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 319795002322 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 319795002323 trimer interface [polypeptide binding]; other site 319795002324 active site 319795002325 substrate binding site [chemical binding]; other site 319795002326 CoA binding site [chemical binding]; other site 319795002327 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 319795002328 catalytic triad [active] 319795002329 conserved cis-peptide bond; other site 319795002330 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 319795002331 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 319795002332 NAD binding site [chemical binding]; other site 319795002333 homotetramer interface [polypeptide binding]; other site 319795002334 homodimer interface [polypeptide binding]; other site 319795002335 substrate binding site [chemical binding]; other site 319795002336 active site 319795002337 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 319795002338 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 319795002339 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 319795002340 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 319795002341 motif II; other site 319795002342 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 319795002343 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 319795002344 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 319795002345 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 319795002346 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 319795002347 Walker A motif; other site 319795002348 ATP binding site [chemical binding]; other site 319795002349 Walker B motif; other site 319795002350 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 319795002351 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 319795002352 Walker A motif; other site 319795002353 ATP binding site [chemical binding]; other site 319795002354 Walker B motif; other site 319795002355 Domain of unknown function (DUF4403); Region: DUF4403; pfam14356 319795002356 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 319795002357 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 319795002358 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 319795002359 Uncharacterized conserved protein [Function unknown]; Region: COG0432 319795002360 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 319795002361 active site 319795002362 dimer interface [polypeptide binding]; other site 319795002363 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 319795002364 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 319795002365 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 319795002366 active site 319795002367 EamA-like transporter family; Region: EamA; pfam00892 319795002368 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 319795002369 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 319795002370 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 319795002371 active site 319795002372 metal binding site [ion binding]; metal-binding site 319795002373 hypothetical protein; Provisional; Region: PRK02395 319795002374 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 319795002375 putative active site [active] 319795002376 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 319795002377 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 319795002378 putative active site [active] 319795002379 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 319795002380 M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896 319795002381 putative metal binding site [ion binding]; other site 319795002382 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 319795002383 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 319795002384 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 319795002385 Active site serine [active] 319795002386 Amino acid permease; Region: AA_permease_2; pfam13520 319795002387 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 319795002388 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 319795002389 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 319795002390 dimerization interface [polypeptide binding]; other site 319795002391 DPS ferroxidase diiron center [ion binding]; other site 319795002392 ion pore; other site 319795002393 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 319795002394 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 319795002395 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 319795002396 GTP binding site; other site 319795002397 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 319795002398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 319795002399 S-adenosylmethionine binding site [chemical binding]; other site 319795002400 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 319795002401 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 319795002402 active site 319795002403 (T/H)XGH motif; other site 319795002404 S-adenosylmethionine synthetase; Validated; Region: PRK05250 319795002405 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 319795002406 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 319795002407 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 319795002408 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 319795002409 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 319795002410 Coenzyme A binding pocket [chemical binding]; other site 319795002411 Protein of unknown function (DUF3809); Region: DUF3809; pfam12723 319795002412 Protein of unknown function (DUF3248); Region: DUF3248; pfam11609 319795002413 Arginase family; Region: Arginase; cd09989 319795002414 agmatinase; Region: agmatinase; TIGR01230 319795002415 active site 319795002416 Mn binding site [ion binding]; other site 319795002417 oligomer interface [polypeptide binding]; other site 319795002418 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 319795002419 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 319795002420 putative active site [active] 319795002421 putative metal binding site [ion binding]; other site 319795002422 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 319795002423 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231; cd11544 319795002424 homodimer interface [polypeptide binding]; other site 319795002425 active site 319795002426 metal binding site [ion binding]; metal-binding site 319795002427 DdrB-like protein; Region: DdrB; pfam12747 319795002428 Predicted type IV restriction endonuclease [Defense mechanisms]; Region: COG2810 319795002429 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 319795002430 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 319795002431 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 319795002432 CoenzymeA binding site [chemical binding]; other site 319795002433 subunit interaction site [polypeptide binding]; other site 319795002434 PHB binding site; other site 319795002435 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 319795002436 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 319795002437 metal binding site [ion binding]; metal-binding site 319795002438 NAD-dependent deacetylase; Provisional; Region: PRK00481 319795002439 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 319795002440 NAD+ binding site [chemical binding]; other site 319795002441 substrate binding site [chemical binding]; other site 319795002442 Zn binding site [ion binding]; other site 319795002443 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 319795002444 catalytic motif [active] 319795002445 Zn binding site [ion binding]; other site 319795002446 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 319795002447 RibD C-terminal domain; Region: RibD_C; cl17279 319795002448 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 319795002449 Lumazine binding domain; Region: Lum_binding; pfam00677 319795002450 Lumazine binding domain; Region: Lum_binding; pfam00677 319795002451 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 319795002452 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 319795002453 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 319795002454 dimerization interface [polypeptide binding]; other site 319795002455 active site 319795002456 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 319795002457 homopentamer interface [polypeptide binding]; other site 319795002458 active site 319795002459 Fe-S oxidoreductase, related to NifB/MoaA family [Energy production and conversion]; Region: COG1625 319795002460 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 319795002461 Protein of unknown function (DUF512); Region: DUF512; pfam04459 319795002462 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 319795002463 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 319795002464 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 319795002465 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 319795002466 metal ion-dependent adhesion site (MIDAS); other site 319795002467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719 319795002468 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795002469 Domain of unknown function DUF11; Region: DUF11; cl17728 319795002470 Domain of unknown function DUF11; Region: DUF11; pfam01345 319795002471 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 319795002472 cell surface protein SprA; Region: surface_SprA; TIGR04189 319795002473 Domain of unknown function DUF11; Region: DUF11; pfam01345 319795002474 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 319795002475 EamA-like transporter family; Region: EamA; pfam00892 319795002476 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 319795002477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 319795002478 active site 319795002479 phosphorylation site [posttranslational modification] 319795002480 intermolecular recognition site; other site 319795002481 dimerization interface [polypeptide binding]; other site 319795002482 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 319795002483 DNA binding residues [nucleotide binding] 319795002484 dimerization interface [polypeptide binding]; other site 319795002485 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 319795002486 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 319795002487 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 319795002488 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 319795002489 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 319795002490 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 319795002491 iron-sulfur cluster [ion binding]; other site 319795002492 [2Fe-2S] cluster binding site [ion binding]; other site 319795002493 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 319795002494 intrachain domain interface; other site 319795002495 heme bL binding site [chemical binding]; other site 319795002496 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 319795002497 heme bH binding site [chemical binding]; other site 319795002498 Qo binding site; other site 319795002499 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 319795002500 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 319795002501 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 319795002502 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 319795002503 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 319795002504 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 319795002505 peptide binding site [polypeptide binding]; other site 319795002506 dimer interface [polypeptide binding]; other site 319795002507 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 319795002508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 319795002509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795002510 dimer interface [polypeptide binding]; other site 319795002511 conserved gate region; other site 319795002512 putative PBP binding loops; other site 319795002513 ABC-ATPase subunit interface; other site 319795002514 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 319795002515 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 319795002516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795002517 putative PBP binding loops; other site 319795002518 dimer interface [polypeptide binding]; other site 319795002519 ABC-ATPase subunit interface; other site 319795002520 Holliday junction resolvasome, endonuclease subunit [DNA replication, recombination, and repair]; Region: RuvC; COG0817 319795002521 active site 319795002522 putative DNA-binding cleft [nucleotide binding]; other site 319795002523 dimer interface [polypeptide binding]; other site 319795002524 Protease prsW family; Region: PrsW-protease; cl15823 319795002525 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 319795002526 MoaE interaction surface [polypeptide binding]; other site 319795002527 MoeB interaction surface [polypeptide binding]; other site 319795002528 thiocarboxylated glycine; other site 319795002529 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 319795002530 MoaE homodimer interface [polypeptide binding]; other site 319795002531 MoaD interaction [polypeptide binding]; other site 319795002532 active site residues [active] 319795002533 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 319795002534 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 319795002535 S-layer homology domain; Region: SLH; pfam00395 319795002536 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 319795002537 DHH family; Region: DHH; pfam01368 319795002538 DHHA2 domain; Region: DHHA2; pfam02833 319795002539 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 319795002540 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 319795002541 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 319795002542 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 319795002543 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 319795002544 active site 319795002545 Zn binding site [ion binding]; other site 319795002546 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 319795002547 sequence-specific DNA binding site [nucleotide binding]; other site 319795002548 salt bridge; other site 319795002549 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 319795002550 trimer interface [polypeptide binding]; other site 319795002551 dimer interface [polypeptide binding]; other site 319795002552 putative active site [active] 319795002553 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 319795002554 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 319795002555 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 319795002556 substrate binding site; other site 319795002557 metal-binding site 319795002558 Oligomer interface; other site 319795002559 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 319795002560 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 319795002561 Substrate binding site; other site 319795002562 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 319795002563 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 319795002564 Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022 319795002565 Bacterial sugar transferase; Region: Bac_transf; pfam02397 319795002566 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 319795002567 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 319795002568 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 319795002569 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 319795002570 active site 319795002571 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 319795002572 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 319795002573 serine O-acetyltransferase; Region: cysE; TIGR01172 319795002574 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 319795002575 trimer interface [polypeptide binding]; other site 319795002576 active site 319795002577 substrate binding site [chemical binding]; other site 319795002578 CoA binding site [chemical binding]; other site 319795002579 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 319795002580 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 319795002581 putative ADP-binding pocket [chemical binding]; other site 319795002582 O-Antigen ligase; Region: Wzy_C; pfam04932 319795002583 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 319795002584 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 319795002585 active site 319795002586 substrate binding site [chemical binding]; other site 319795002587 metal binding site [ion binding]; metal-binding site 319795002588 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 319795002589 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 319795002590 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 319795002591 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 319795002592 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 319795002593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 319795002594 active site 319795002595 phosphorylation site [posttranslational modification] 319795002596 intermolecular recognition site; other site 319795002597 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 319795002598 dimerization interface [polypeptide binding]; other site 319795002599 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 319795002600 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 319795002601 ATP binding site [chemical binding]; other site 319795002602 Mg2+ binding site [ion binding]; other site 319795002603 G-X-G motif; other site 319795002604 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 319795002605 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 319795002606 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 319795002607 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 319795002608 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 319795002609 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 319795002610 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 319795002611 substrate binding site [chemical binding]; other site 319795002612 ATP binding site [chemical binding]; other site 319795002613 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 319795002614 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 319795002615 putative metal binding site [ion binding]; other site 319795002616 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 319795002617 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 319795002618 ATP binding site [chemical binding]; other site 319795002619 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 319795002620 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 319795002621 oligomer interface [polypeptide binding]; other site 319795002622 metal binding site [ion binding]; metal-binding site 319795002623 metal binding site [ion binding]; metal-binding site 319795002624 putative Cl binding site [ion binding]; other site 319795002625 aspartate ring; other site 319795002626 basic sphincter; other site 319795002627 hydrophobic gate; other site 319795002628 periplasmic entrance; other site 319795002629 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 319795002630 NMT1/THI5 like; Region: NMT1; pfam09084 319795002631 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 319795002632 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 319795002633 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 319795002634 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 319795002635 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 319795002636 metal binding site [ion binding]; metal-binding site 319795002637 dimer interface [polypeptide binding]; other site 319795002638 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 319795002639 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 319795002640 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 319795002641 Coenzyme A binding pocket [chemical binding]; other site 319795002642 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 319795002643 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 319795002644 Coenzyme A binding pocket [chemical binding]; other site 319795002645 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 319795002646 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 319795002647 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 319795002648 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 319795002649 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 319795002650 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 319795002651 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 319795002652 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 319795002653 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 319795002654 Switch I; other site 319795002655 Switch II; other site 319795002656 cell division topological specificity factor MinE; Region: minE; TIGR01215 319795002657 short chain dehydrogenase; Provisional; Region: PRK08303 319795002658 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 319795002659 NAD(P) binding site [chemical binding]; other site 319795002660 active site 319795002661 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 319795002662 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 319795002663 active site 319795002664 catalytic tetrad [active] 319795002665 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 319795002666 TPR motif; other site 319795002667 binding surface 319795002668 Tetratricopeptide repeat; Region: TPR_12; pfam13424 319795002669 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 319795002670 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 319795002671 metal binding site [ion binding]; metal-binding site 319795002672 active site 319795002673 I-site; other site 319795002674 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 319795002675 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 319795002676 Walker A/P-loop; other site 319795002677 ATP binding site [chemical binding]; other site 319795002678 Q-loop/lid; other site 319795002679 ABC transporter signature motif; other site 319795002680 Walker B; other site 319795002681 D-loop; other site 319795002682 H-loop/switch region; other site 319795002683 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 319795002684 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 319795002685 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 319795002686 XdhC Rossmann domain; Region: XdhC_C; pfam13478 319795002687 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 319795002688 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 319795002689 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 319795002690 4Fe-4S binding domain; Region: Fer4; pfam00037 319795002691 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 319795002692 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 319795002693 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 319795002694 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 319795002695 dimer interface [polypeptide binding]; other site 319795002696 phosphorylation site [posttranslational modification] 319795002697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 319795002698 ATP binding site [chemical binding]; other site 319795002699 Mg2+ binding site [ion binding]; other site 319795002700 G-X-G motif; other site 319795002701 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 319795002702 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 319795002703 ATP binding site [chemical binding]; other site 319795002704 putative Mg++ binding site [ion binding]; other site 319795002705 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 319795002706 nucleotide binding region [chemical binding]; other site 319795002707 ATP-binding site [chemical binding]; other site 319795002708 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 319795002709 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 319795002710 Uncharacterized conserved protein [Function unknown]; Region: COG3375 319795002711 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 319795002712 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 319795002713 active site 319795002714 octamer interface [polypeptide binding]; other site 319795002715 Acyl CoA binding protein; Region: ACBP; pfam00887 319795002716 acyl-CoA binding pocket [chemical binding]; other site 319795002717 CoA binding site [chemical binding]; other site 319795002718 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 319795002719 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 319795002720 dihydropteroate synthase; Region: DHPS; TIGR01496 319795002721 substrate binding pocket [chemical binding]; other site 319795002722 dimer interface [polypeptide binding]; other site 319795002723 inhibitor binding site; inhibition site 319795002724 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 319795002725 active site 319795002726 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 319795002727 catalytic center binding site [active] 319795002728 ATP binding site [chemical binding]; other site 319795002729 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 319795002730 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 319795002731 RNase E interface [polypeptide binding]; other site 319795002732 trimer interface [polypeptide binding]; other site 319795002733 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 319795002734 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 319795002735 RNase E interface [polypeptide binding]; other site 319795002736 trimer interface [polypeptide binding]; other site 319795002737 active site 319795002738 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 319795002739 putative nucleic acid binding region [nucleotide binding]; other site 319795002740 G-X-X-G motif; other site 319795002741 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 319795002742 RNA binding site [nucleotide binding]; other site 319795002743 domain interface; other site 319795002744 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 319795002745 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 319795002746 putative [4Fe-4S] binding site [ion binding]; other site 319795002747 putative molybdopterin cofactor binding site [chemical binding]; other site 319795002748 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 319795002749 putative molybdopterin cofactor binding site; other site 319795002750 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 319795002751 ArsC family; Region: ArsC; pfam03960 319795002752 catalytic residue [active] 319795002753 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 319795002754 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 319795002755 Walker A motif; other site 319795002756 ATP binding site [chemical binding]; other site 319795002757 Walker B motif; other site 319795002758 arginine finger; other site 319795002759 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 319795002760 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 319795002761 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 319795002762 Cu(I) binding site [ion binding]; other site 319795002763 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 319795002764 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 319795002765 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 319795002766 Subunit I/III interface [polypeptide binding]; other site 319795002767 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 319795002768 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 319795002769 Cytochrome c; Region: Cytochrom_C; pfam00034 319795002770 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 319795002771 UbiA prenyltransferase family; Region: UbiA; pfam01040 319795002772 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 319795002773 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 319795002774 Protein of unknown function (DUF420); Region: DUF420; cl00989 319795002775 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 319795002776 oligomerization interface [polypeptide binding]; other site 319795002777 active site 319795002778 metal binding site [ion binding]; metal-binding site 319795002779 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 319795002780 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 319795002781 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 319795002782 GatB domain; Region: GatB_Yqey; smart00845 319795002783 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 319795002784 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 319795002785 substrate binding site [chemical binding]; other site 319795002786 ATP binding site [chemical binding]; other site 319795002787 YceG-like family; Region: YceG; pfam02618 319795002788 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 319795002789 dimerization interface [polypeptide binding]; other site 319795002790 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 319795002791 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 319795002792 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 319795002793 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 319795002794 active site 319795002795 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 319795002796 putative active site [active] 319795002797 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 319795002798 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 319795002799 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 319795002800 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 319795002801 dimer interface [polypeptide binding]; other site 319795002802 acyl-activating enzyme (AAE) consensus motif; other site 319795002803 putative active site [active] 319795002804 AMP binding site [chemical binding]; other site 319795002805 putative CoA binding site [chemical binding]; other site 319795002806 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 319795002807 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 319795002808 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 319795002809 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 319795002810 Walker A motif; other site 319795002811 ATP binding site [chemical binding]; other site 319795002812 Walker B motif; other site 319795002813 arginine finger; other site 319795002814 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 319795002815 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 319795002816 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 319795002817 active site 319795002818 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 319795002819 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 319795002820 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 319795002821 active site 319795002822 DNA binding site [nucleotide binding] 319795002823 Int/Topo IB signature motif; other site 319795002824 trigger factor; Region: tig; TIGR00115 319795002825 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 319795002826 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 319795002827 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 319795002828 dimer interface [polypeptide binding]; other site 319795002829 active site 319795002830 CoA binding pocket [chemical binding]; other site 319795002831 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 319795002832 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 319795002833 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 319795002834 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 319795002835 NAD(P) binding site [chemical binding]; other site 319795002836 homotetramer interface [polypeptide binding]; other site 319795002837 homodimer interface [polypeptide binding]; other site 319795002838 active site 319795002839 acyl carrier protein; Provisional; Region: acpP; PRK00982 319795002840 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 319795002841 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 319795002842 dimer interface [polypeptide binding]; other site 319795002843 active site 319795002844 polyphosphate kinase; Provisional; Region: PRK05443 319795002845 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 319795002846 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 319795002847 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 319795002848 putative domain interface [polypeptide binding]; other site 319795002849 putative active site [active] 319795002850 catalytic site [active] 319795002851 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 319795002852 putative domain interface [polypeptide binding]; other site 319795002853 putative active site [active] 319795002854 catalytic site [active] 319795002855 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 319795002856 binding surface 319795002857 TPR motif; other site 319795002858 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 319795002859 putative substrate binding pocket [chemical binding]; other site 319795002860 AC domain interface; other site 319795002861 catalytic triad [active] 319795002862 AB domain interface; other site 319795002863 interchain disulfide; other site 319795002864 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK14811 319795002865 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 319795002866 DNA binding site [nucleotide binding] 319795002867 catalytic residue [active] 319795002868 H2TH interface [polypeptide binding]; other site 319795002869 putative catalytic residues [active] 319795002870 turnover-facilitating residue; other site 319795002871 intercalation triad [nucleotide binding]; other site 319795002872 8OG recognition residue [nucleotide binding]; other site 319795002873 putative reading head residues; other site 319795002874 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 319795002875 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 319795002876 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 319795002877 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 319795002878 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 319795002879 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 319795002880 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 319795002881 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 319795002882 futalosine nucleosidase; Region: fut_nucase; TIGR03664 319795002883 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 319795002884 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 319795002885 NAD(P) binding site [chemical binding]; other site 319795002886 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 319795002887 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 319795002888 active site 319795002889 HIGH motif; other site 319795002890 dimer interface [polypeptide binding]; other site 319795002891 KMSKS motif; other site 319795002892 chaperone protein DnaJ; Provisional; Region: PRK14292 319795002893 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 319795002894 HSP70 interaction site [polypeptide binding]; other site 319795002895 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 319795002896 Zn binding sites [ion binding]; other site 319795002897 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 319795002898 dimer interface [polypeptide binding]; other site 319795002899 ribose-phosphate pyrophosphokinase; Region: ribP_PPkin; TIGR01251 319795002900 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 319795002901 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 319795002902 active site 319795002903 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 319795002904 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 319795002905 active site 319795002906 metal binding site [ion binding]; metal-binding site 319795002907 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 319795002908 active site 319795002909 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 319795002910 [2Fe-2S] cluster binding site [ion binding]; other site 319795002911 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 319795002912 active site 319795002913 catalytic residues [active] 319795002914 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 319795002915 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 319795002916 NAD(P) binding site [chemical binding]; other site 319795002917 active site 319795002918 Uncharacterized conserved protein [Function unknown]; Region: COG4850 319795002919 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 319795002920 ribonuclease R; Region: RNase_R; TIGR02063 319795002921 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 319795002922 RNB domain; Region: RNB; pfam00773 319795002923 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 319795002924 RNA binding site [nucleotide binding]; other site 319795002925 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 319795002926 putative catalytic site [active] 319795002927 putative metal binding site [ion binding]; other site 319795002928 putative phosphate binding site [ion binding]; other site 319795002929 Methyltransferase domain; Region: Methyltransf_11; pfam08241 319795002930 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795002931 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 319795002932 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 319795002933 ATP-grasp domain; Region: ATP-grasp_4; cl17255 319795002934 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 319795002935 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 319795002936 carboxyltransferase (CT) interaction site; other site 319795002937 biotinylation site [posttranslational modification]; other site 319795002938 elongation factor P; Validated; Region: PRK00529 319795002939 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 319795002940 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 319795002941 RNA binding site [nucleotide binding]; other site 319795002942 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 319795002943 RNA binding site [nucleotide binding]; other site 319795002944 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 319795002945 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 319795002946 5S rRNA interface [nucleotide binding]; other site 319795002947 CTC domain interface [polypeptide binding]; other site 319795002948 L16 interface [polypeptide binding]; other site 319795002949 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 319795002950 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 319795002951 FeS assembly protein SufD; Region: sufD; TIGR01981 319795002952 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 319795002953 FeS assembly protein SufB; Region: sufB; TIGR01980 319795002954 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 319795002955 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 319795002956 Walker A/P-loop; other site 319795002957 ATP binding site [chemical binding]; other site 319795002958 Q-loop/lid; other site 319795002959 ABC transporter signature motif; other site 319795002960 Walker B; other site 319795002961 D-loop; other site 319795002962 H-loop/switch region; other site 319795002963 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 319795002964 homodimer interface [polypeptide binding]; other site 319795002965 maltodextrin glucosidase; Provisional; Region: PRK10785 319795002966 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 319795002967 active site 319795002968 homodimer interface [polypeptide binding]; other site 319795002969 catalytic site [active] 319795002970 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 319795002971 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 319795002972 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 319795002973 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 319795002974 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 319795002975 DNA binding residues [nucleotide binding] 319795002976 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 319795002977 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 319795002978 trmE is a tRNA modification GTPase; Region: trmE; cd04164 319795002979 G1 box; other site 319795002980 GTP/Mg2+ binding site [chemical binding]; other site 319795002981 Switch I region; other site 319795002982 G2 box; other site 319795002983 Switch II region; other site 319795002984 G3 box; other site 319795002985 G4 box; other site 319795002986 G5 box; other site 319795002987 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 319795002988 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 319795002989 TPR motif; other site 319795002990 binding surface 319795002991 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 319795002992 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 319795002993 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 319795002994 Coenzyme A binding pocket [chemical binding]; other site 319795002995 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 319795002996 putative active site [active] 319795002997 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 319795002998 Glucose inhibited division protein A; Region: GIDA; pfam01134 319795002999 UDP-N-acetylmuramoylalanine--D-glutamate ligase; Region: murD; TIGR01087 319795003000 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 319795003001 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 319795003002 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 319795003003 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 319795003004 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 319795003005 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 319795003006 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 319795003007 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 319795003008 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 319795003009 active site 319795003010 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 319795003011 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 319795003012 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 319795003013 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 319795003014 NAD(P) binding site [chemical binding]; other site 319795003015 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 319795003016 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 319795003017 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 319795003018 NAD(P) binding site [chemical binding]; other site 319795003019 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 319795003020 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 319795003021 substrate binding pocket [chemical binding]; other site 319795003022 chain length determination region; other site 319795003023 substrate-Mg2+ binding site; other site 319795003024 catalytic residues [active] 319795003025 aspartate-rich region 1; other site 319795003026 active site lid residues [active] 319795003027 aspartate-rich region 2; other site 319795003028 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 319795003029 homodimer interface [polypeptide binding]; other site 319795003030 substrate-cofactor binding pocket; other site 319795003031 Aminotransferase class IV; Region: Aminotran_4; pfam01063 319795003032 pyridoxal 5'-phosphate binding site [chemical binding]; other site 319795003033 catalytic residue [active] 319795003034 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 319795003035 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 319795003036 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 319795003037 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 319795003038 Glutamine amidotransferase class-I; Region: GATase; pfam00117 319795003039 glutamine binding [chemical binding]; other site 319795003040 catalytic triad [active] 319795003041 Transcriptional regulator; Region: Rrf2; cl17282 319795003042 Rrf2 family protein; Region: rrf2_super; TIGR00738 319795003043 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 319795003044 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 319795003045 quinone interaction residues [chemical binding]; other site 319795003046 active site 319795003047 catalytic residues [active] 319795003048 FMN binding site [chemical binding]; other site 319795003049 substrate binding site [chemical binding]; other site 319795003050 dihydroorotase; Validated; Region: pyrC; PRK09357 319795003051 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 319795003052 active site 319795003053 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 319795003054 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 319795003055 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 319795003056 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 319795003057 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 319795003058 active site 319795003059 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 319795003060 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 319795003061 putative dimer interface [polypeptide binding]; other site 319795003062 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 319795003063 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 319795003064 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 319795003065 Walker A/P-loop; other site 319795003066 ATP binding site [chemical binding]; other site 319795003067 Q-loop/lid; other site 319795003068 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 319795003069 ABC transporter signature motif; other site 319795003070 Walker B; other site 319795003071 D-loop; other site 319795003072 ABC transporter; Region: ABC_tran_2; pfam12848 319795003073 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 319795003074 Family of unknown function (DUF490); Region: DUF490; pfam04357 319795003075 acylphosphatase; Provisional; Region: PRK14433 319795003076 FRG domain; Region: FRG; pfam08867 319795003077 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 319795003078 homotrimer interaction site [polypeptide binding]; other site 319795003079 putative active site [active] 319795003080 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 319795003081 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 319795003082 purine monophosphate binding site [chemical binding]; other site 319795003083 dimer interface [polypeptide binding]; other site 319795003084 putative catalytic residues [active] 319795003085 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 319795003086 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 319795003087 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 319795003088 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 319795003089 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 319795003090 homodimer interface [polypeptide binding]; other site 319795003091 NADP binding site [chemical binding]; other site 319795003092 substrate binding site [chemical binding]; other site 319795003093 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 319795003094 N-acetyl-glucosamine transferase is involved in the synthesis of Poly-beta-1,6-N-acetyl-D-glucosamine; Region: GlcNAc-1-P_transferase; cd06436 319795003095 DXD motif; other site 319795003096 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 319795003097 amphipathic channel; other site 319795003098 Asn-Pro-Ala signature motifs; other site 319795003099 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 319795003100 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 319795003101 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 319795003102 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 319795003103 homodimer interface [polypeptide binding]; other site 319795003104 substrate-cofactor binding pocket; other site 319795003105 pyridoxal 5'-phosphate binding site [chemical binding]; other site 319795003106 catalytic residue [active] 319795003107 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 319795003108 metal binding site 2 [ion binding]; metal-binding site 319795003109 putative DNA binding helix; other site 319795003110 metal binding site 1 [ion binding]; metal-binding site 319795003111 dimer interface [polypeptide binding]; other site 319795003112 structural Zn2+ binding site [ion binding]; other site 319795003113 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 319795003114 S-adenosylmethionine binding site [chemical binding]; other site 319795003115 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 319795003116 active site lid residues [active] 319795003117 substrate binding pocket [chemical binding]; other site 319795003118 catalytic residues [active] 319795003119 substrate-Mg2+ binding site; other site 319795003120 aspartate-rich region 1; other site 319795003121 aspartate-rich region 2; other site 319795003122 phytoene desaturase; Region: crtI_fam; TIGR02734 319795003123 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 319795003124 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 319795003125 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 319795003126 Predicted transcriptional regulators [Transcription]; Region: COG1733 319795003127 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 319795003128 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 319795003129 dimer interface [polypeptide binding]; other site 319795003130 FMN binding site [chemical binding]; other site 319795003131 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 319795003132 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 319795003133 NAD(P) binding site [chemical binding]; other site 319795003134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 319795003135 Major Facilitator Superfamily; Region: MFS_1; pfam07690 319795003136 putative substrate translocation pore; other site 319795003137 Uncharacterized conserved protein [Function unknown]; Region: COG5649 319795003138 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 319795003139 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 319795003140 ABC-ATPase subunit interface; other site 319795003141 dimer interface [polypeptide binding]; other site 319795003142 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 319795003143 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 319795003144 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 319795003145 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 319795003146 intersubunit interface [polypeptide binding]; other site 319795003147 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 319795003148 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 319795003149 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 319795003150 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 319795003151 trehalose synthase; Region: treS_nterm; TIGR02456 319795003152 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 319795003153 active site 319795003154 catalytic site [active] 319795003155 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 319795003156 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 319795003157 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 319795003158 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 319795003159 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 319795003160 active site 319795003161 catalytic site [active] 319795003162 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 319795003163 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 319795003164 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 319795003165 catalytic site [active] 319795003166 active site 319795003167 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 319795003168 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 319795003169 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 319795003170 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 319795003171 active site 319795003172 catalytic site [active] 319795003173 NMT1-like family; Region: NMT1_2; pfam13379 319795003174 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 319795003175 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 319795003176 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 319795003177 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 319795003178 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 319795003179 ATP binding site [chemical binding]; other site 319795003180 putative Mg++ binding site [ion binding]; other site 319795003181 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 319795003182 nucleotide binding region [chemical binding]; other site 319795003183 ATP-binding site [chemical binding]; other site 319795003184 TRCF domain; Region: TRCF; pfam03461 319795003185 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 319795003186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 319795003187 Mg2+ binding site [ion binding]; other site 319795003188 G-X-G motif; other site 319795003189 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 319795003190 anchoring element; other site 319795003191 dimer interface [polypeptide binding]; other site 319795003192 ATP binding site [chemical binding]; other site 319795003193 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 319795003194 active site 319795003195 putative metal-binding site [ion binding]; other site 319795003196 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 319795003197 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 319795003198 metal ion-dependent adhesion site (MIDAS); other site 319795003199 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 319795003200 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 319795003201 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 319795003202 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 319795003203 active site 319795003204 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 319795003205 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 319795003206 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 319795003207 Peptidase family M50; Region: Peptidase_M50; pfam02163 319795003208 active site 319795003209 putative substrate binding region [chemical binding]; other site 319795003210 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 319795003211 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 319795003212 active site 319795003213 NTP binding site [chemical binding]; other site 319795003214 metal binding triad [ion binding]; metal-binding site 319795003215 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 319795003216 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 319795003217 protein binding site [polypeptide binding]; other site 319795003218 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 319795003219 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 319795003220 dimerization interface [polypeptide binding]; other site 319795003221 domain crossover interface; other site 319795003222 redox-dependent activation switch; other site 319795003223 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 319795003224 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 319795003225 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 319795003226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 319795003227 active site 319795003228 phosphorylation site [posttranslational modification] 319795003229 intermolecular recognition site; other site 319795003230 dimerization interface [polypeptide binding]; other site 319795003231 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 319795003232 DNA binding residues [nucleotide binding] 319795003233 dimerization interface [polypeptide binding]; other site 319795003234 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 319795003235 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 319795003236 GAF domain; Region: GAF; pfam01590 319795003237 PAS domain S-box; Region: sensory_box; TIGR00229 319795003238 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 319795003239 putative active site [active] 319795003240 heme pocket [chemical binding]; other site 319795003241 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 319795003242 Histidine kinase; Region: HisKA_3; pfam07730 319795003243 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 319795003244 ATP binding site [chemical binding]; other site 319795003245 Mg2+ binding site [ion binding]; other site 319795003246 G-X-G motif; other site 319795003247 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 319795003248 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 319795003249 putative ADP-binding pocket [chemical binding]; other site 319795003250 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 319795003251 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 319795003252 active site 319795003253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 319795003254 putative substrate translocation pore; other site 319795003255 Major Facilitator Superfamily; Region: MFS_1; pfam07690 319795003256 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 319795003257 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 319795003258 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 319795003259 conserved hypothetical protein; Region: TIGR03492 319795003260 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 319795003261 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 319795003262 catalytic site [active] 319795003263 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 319795003264 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 319795003265 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 319795003266 metal binding site [ion binding]; metal-binding site 319795003267 active site 319795003268 I-site; other site 319795003269 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 319795003270 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 319795003271 HIGH motif; other site 319795003272 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 319795003273 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 319795003274 active site 319795003275 KMSKS motif; other site 319795003276 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 319795003277 tRNA binding surface [nucleotide binding]; other site 319795003278 EamA-like transporter family; Region: EamA; cl17759 319795003279 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 319795003280 prolyl-tRNA synthetase; Provisional; Region: PRK08661 319795003281 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 319795003282 dimer interface [polypeptide binding]; other site 319795003283 motif 1; other site 319795003284 active site 319795003285 motif 2; other site 319795003286 motif 3; other site 319795003287 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 319795003288 anticodon binding site; other site 319795003289 zinc-binding site [ion binding]; other site 319795003290 Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; cl01558 319795003291 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 319795003292 trehalose synthase; Region: treS_nterm; TIGR02456 319795003293 active site 319795003294 catalytic site [active] 319795003295 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 319795003296 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 319795003297 23S rRNA binding site [nucleotide binding]; other site 319795003298 L21 binding site [polypeptide binding]; other site 319795003299 L13 binding site [polypeptide binding]; other site 319795003300 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 319795003301 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 319795003302 nucleotide binding site [chemical binding]; other site 319795003303 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 319795003304 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 319795003305 active site 319795003306 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 319795003307 thymidine kinase; Provisional; Region: PRK04296 319795003308 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 319795003309 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 319795003310 metal binding site [ion binding]; metal-binding site 319795003311 active site 319795003312 I-site; other site 319795003313 Transcriptional regulators [Transcription]; Region: PurR; COG1609 319795003314 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 319795003315 DNA binding site [nucleotide binding] 319795003316 domain linker motif; other site 319795003317 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 319795003318 Protein of unknown function (DUF461); Region: DUF461; pfam04314 319795003319 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 319795003320 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 319795003321 Cu(I) binding site [ion binding]; other site 319795003322 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 319795003323 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 319795003324 histidinol dehydrogenase; Region: hisD; TIGR00069 319795003325 NAD binding site [chemical binding]; other site 319795003326 dimerization interface [polypeptide binding]; other site 319795003327 product binding site; other site 319795003328 substrate binding site [chemical binding]; other site 319795003329 zinc binding site [ion binding]; other site 319795003330 catalytic residues [active] 319795003331 phosphopentomutase; Provisional; Region: PRK05362 319795003332 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 319795003333 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 319795003334 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 319795003335 Walker A/P-loop; other site 319795003336 ATP binding site [chemical binding]; other site 319795003337 Q-loop/lid; other site 319795003338 ABC transporter signature motif; other site 319795003339 Walker B; other site 319795003340 D-loop; other site 319795003341 H-loop/switch region; other site 319795003342 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 319795003343 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 319795003344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795003345 dimer interface [polypeptide binding]; other site 319795003346 conserved gate region; other site 319795003347 putative PBP binding loops; other site 319795003348 ABC-ATPase subunit interface; other site 319795003349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795003350 dimer interface [polypeptide binding]; other site 319795003351 conserved gate region; other site 319795003352 putative PBP binding loops; other site 319795003353 ABC-ATPase subunit interface; other site 319795003354 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 319795003355 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 319795003356 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 319795003357 Divergent AAA domain; Region: AAA_4; pfam04326 319795003358 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 319795003359 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 319795003360 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 319795003361 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 319795003362 Permutation of conserved domain; other site 319795003363 active site 319795003364 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 319795003365 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 319795003366 MPT binding site; other site 319795003367 trimer interface [polypeptide binding]; other site 319795003368 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 319795003369 GMP synthase; Reviewed; Region: guaA; PRK00074 319795003370 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 319795003371 AMP/PPi binding site [chemical binding]; other site 319795003372 candidate oxyanion hole; other site 319795003373 catalytic triad [active] 319795003374 potential glutamine specificity residues [chemical binding]; other site 319795003375 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 319795003376 ATP Binding subdomain [chemical binding]; other site 319795003377 Ligand Binding sites [chemical binding]; other site 319795003378 Dimerization subdomain; other site 319795003379 2-isopropylmalate synthase; Validated; Region: PRK00915 319795003380 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 319795003381 active site 319795003382 catalytic residues [active] 319795003383 metal binding site [ion binding]; metal-binding site 319795003384 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 319795003385 ketol-acid reductoisomerase; Provisional; Region: PRK05479 319795003386 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 319795003387 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 319795003388 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 319795003389 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 319795003390 putative valine binding site [chemical binding]; other site 319795003391 dimer interface [polypeptide binding]; other site 319795003392 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 319795003393 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 319795003394 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 319795003395 PYR/PP interface [polypeptide binding]; other site 319795003396 dimer interface [polypeptide binding]; other site 319795003397 TPP binding site [chemical binding]; other site 319795003398 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 319795003399 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 319795003400 TPP-binding site [chemical binding]; other site 319795003401 dimer interface [polypeptide binding]; other site 319795003402 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 319795003403 DEAD-like helicases superfamily; Region: DEXDc; smart00487 319795003404 ATP binding site [chemical binding]; other site 319795003405 Mg++ binding site [ion binding]; other site 319795003406 motif III; other site 319795003407 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 319795003408 nucleotide binding region [chemical binding]; other site 319795003409 ATP-binding site [chemical binding]; other site 319795003410 RNA-binding GUCT-like domain found in Thermus thermophilus heat resistant RNA-dependent ATPase (Hera) and similar proteins; Region: GUCT_Hera; cd12938 319795003411 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 319795003412 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 319795003413 RNA binding surface [nucleotide binding]; other site 319795003414 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 319795003415 active site 319795003416 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 319795003417 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 319795003418 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 319795003419 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 319795003420 DNA binding residues [nucleotide binding] 319795003421 putative anti-sigmaE protein; Provisional; Region: PRK13920 319795003422 Anti-sigma-K factor rskA; Region: RskA; pfam10099 319795003423 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 319795003424 nudix motif; other site 319795003425 peptide chain release factor 1; Validated; Region: prfA; PRK00591 319795003426 PCRF domain; Region: PCRF; pfam03462 319795003427 RF-1 domain; Region: RF-1; pfam00472 319795003428 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 319795003429 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 319795003430 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 319795003431 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 319795003432 active site 319795003433 homodimer interface [polypeptide binding]; other site 319795003434 catalytic site [active] 319795003435 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 319795003436 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 319795003437 metal binding triad [ion binding]; metal-binding site 319795003438 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 319795003439 Zn2+ binding site [ion binding]; other site 319795003440 Mg2+ binding site [ion binding]; other site 319795003441 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 319795003442 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 319795003443 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 319795003444 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 319795003445 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 319795003446 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 319795003447 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 319795003448 enoyl-CoA hydratase; Provisional; Region: PRK06127 319795003449 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 319795003450 substrate binding site [chemical binding]; other site 319795003451 oxyanion hole (OAH) forming residues; other site 319795003452 trimer interface [polypeptide binding]; other site 319795003453 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 319795003454 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 319795003455 dimer interface [polypeptide binding]; other site 319795003456 active site 319795003457 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 319795003458 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 319795003459 putative RNA binding site [nucleotide binding]; other site 319795003460 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 319795003461 S-adenosylmethionine binding site [chemical binding]; other site 319795003462 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 319795003463 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 319795003464 dimerization interface [polypeptide binding]; other site 319795003465 ligand binding site [chemical binding]; other site 319795003466 phosphoenolpyruvate synthase; Validated; Region: PRK06464 319795003467 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 319795003468 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 319795003469 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 319795003470 PEP synthetase regulatory protein; Provisional; Region: PRK05339 319795003471 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 319795003472 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 319795003473 Cysteine-rich domain; Region: CCG; pfam02754 319795003474 Cysteine-rich domain; Region: CCG; pfam02754 319795003475 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 319795003476 FAD binding domain; Region: FAD_binding_4; pfam01565 319795003477 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 319795003478 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 319795003479 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 319795003480 putative active site [active] 319795003481 putative substrate binding site [chemical binding]; other site 319795003482 putative FMN binding site [chemical binding]; other site 319795003483 putative catalytic residues [active] 319795003484 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 319795003485 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 319795003486 active site 319795003487 metal binding site [ion binding]; metal-binding site 319795003488 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 319795003489 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 319795003490 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 319795003491 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 319795003492 CoA binding domain; Region: CoA_binding; pfam02629 319795003493 Sporulation related domain; Region: SPOR; pfam05036 319795003494 Sporulation related domain; Region: SPOR; pfam05036 319795003495 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 319795003496 binding surface 319795003497 TPR motif; other site 319795003498 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 319795003499 TPR motif; other site 319795003500 binding surface 319795003501 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14468 319795003502 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 319795003503 FeS/SAM binding site; other site 319795003504 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 319795003505 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 319795003506 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 319795003507 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 319795003508 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 319795003509 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 319795003510 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 319795003511 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 319795003512 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 319795003513 DNA binding site [nucleotide binding] 319795003514 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 319795003515 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 319795003516 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 319795003517 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 319795003518 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 319795003519 RPB10 interaction site [polypeptide binding]; other site 319795003520 RPB1 interaction site [polypeptide binding]; other site 319795003521 RPB11 interaction site [polypeptide binding]; other site 319795003522 RPB3 interaction site [polypeptide binding]; other site 319795003523 RPB12 interaction site [polypeptide binding]; other site 319795003524 Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700 319795003525 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 319795003526 DNA-binding site [nucleotide binding]; DNA binding site 319795003527 RNA-binding motif; other site 319795003528 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 319795003529 peripheral dimer interface [polypeptide binding]; other site 319795003530 core dimer interface [polypeptide binding]; other site 319795003531 L10 interface [polypeptide binding]; other site 319795003532 L11 interface [polypeptide binding]; other site 319795003533 putative EF-Tu interaction site [polypeptide binding]; other site 319795003534 putative EF-G interaction site [polypeptide binding]; other site 319795003535 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 319795003536 23S rRNA interface [nucleotide binding]; other site 319795003537 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 319795003538 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 319795003539 mRNA/rRNA interface [nucleotide binding]; other site 319795003540 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 319795003541 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 319795003542 23S rRNA interface [nucleotide binding]; other site 319795003543 L7/L12 interface [polypeptide binding]; other site 319795003544 putative thiostrepton binding site; other site 319795003545 L25 interface [polypeptide binding]; other site 319795003546 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 319795003547 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 319795003548 putative homodimer interface [polypeptide binding]; other site 319795003549 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 319795003550 heterodimer interface [polypeptide binding]; other site 319795003551 homodimer interface [polypeptide binding]; other site 319795003552 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 319795003553 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 319795003554 elongation factor Tu; Reviewed; Region: PRK00049 319795003555 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 319795003556 G1 box; other site 319795003557 GEF interaction site [polypeptide binding]; other site 319795003558 GTP/Mg2+ binding site [chemical binding]; other site 319795003559 Switch I region; other site 319795003560 G2 box; other site 319795003561 G3 box; other site 319795003562 Switch II region; other site 319795003563 G4 box; other site 319795003564 G5 box; other site 319795003565 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 319795003566 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 319795003567 Antibiotic Binding Site [chemical binding]; other site 319795003568 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 319795003569 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 319795003570 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 319795003571 Walker A/P-loop; other site 319795003572 ATP binding site [chemical binding]; other site 319795003573 Q-loop/lid; other site 319795003574 ABC transporter signature motif; other site 319795003575 Walker B; other site 319795003576 D-loop; other site 319795003577 H-loop/switch region; other site 319795003578 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 319795003579 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 319795003580 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 319795003581 Walker A/P-loop; other site 319795003582 ATP binding site [chemical binding]; other site 319795003583 Q-loop/lid; other site 319795003584 ABC transporter signature motif; other site 319795003585 Walker B; other site 319795003586 D-loop; other site 319795003587 H-loop/switch region; other site 319795003588 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 319795003589 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 319795003590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795003591 dimer interface [polypeptide binding]; other site 319795003592 conserved gate region; other site 319795003593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 319795003594 ABC-ATPase subunit interface; other site 319795003595 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 319795003596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795003597 dimer interface [polypeptide binding]; other site 319795003598 conserved gate region; other site 319795003599 putative PBP binding loops; other site 319795003600 ABC-ATPase subunit interface; other site 319795003601 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14272 319795003602 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 319795003603 Walker A/P-loop; other site 319795003604 ATP binding site [chemical binding]; other site 319795003605 Q-loop/lid; other site 319795003606 ABC transporter signature motif; other site 319795003607 Walker B; other site 319795003608 D-loop; other site 319795003609 H-loop/switch region; other site 319795003610 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 319795003611 PhoU domain; Region: PhoU; pfam01895 319795003612 PhoU domain; Region: PhoU; pfam01895 319795003613 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 319795003614 tandem repeat interface [polypeptide binding]; other site 319795003615 oligomer interface [polypeptide binding]; other site 319795003616 active site residues [active] 319795003617 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 319795003618 tandem repeat interface [polypeptide binding]; other site 319795003619 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 319795003620 oligomer interface [polypeptide binding]; other site 319795003621 active site residues [active] 319795003622 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 319795003623 heme-binding site [chemical binding]; other site 319795003624 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 319795003625 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 319795003626 intersubunit interface [polypeptide binding]; other site 319795003627 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 319795003628 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 319795003629 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 319795003630 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 319795003631 Cl- selectivity filter; other site 319795003632 Cl- binding residues [ion binding]; other site 319795003633 pore gating glutamate residue; other site 319795003634 TrkA-C domain; Region: TrkA_C; pfam02080 319795003635 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 319795003636 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 319795003637 active site 319795003638 catalytic site [active] 319795003639 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 319795003640 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 319795003641 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 319795003642 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 319795003643 putative active site [active] 319795003644 metal binding site [ion binding]; metal-binding site 319795003645 homodimer binding site [polypeptide binding]; other site 319795003646 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 319795003647 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 319795003648 Zn2+ binding site [ion binding]; other site 319795003649 Mg2+ binding site [ion binding]; other site 319795003650 OstA-like protein; Region: OstA; cl00844 319795003651 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 319795003652 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 319795003653 active site 319795003654 metal binding site [ion binding]; metal-binding site 319795003655 ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636 319795003656 4-alpha-glucanotransferase; Provisional; Region: PRK14508 319795003657 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 319795003658 transcription elongation factor GreA; Region: greA; TIGR01462 319795003659 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 319795003660 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 319795003661 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 319795003662 Walker A motif; other site 319795003663 ATP binding site [chemical binding]; other site 319795003664 Walker B motif; other site 319795003665 Pantoate-beta-alanine ligase; Region: PanC; cd00560 319795003666 pantoate--beta-alanine ligase; Region: panC; TIGR00018 319795003667 active site 319795003668 ATP-binding site [chemical binding]; other site 319795003669 pantoate-binding site; other site 319795003670 HXXH motif; other site 319795003671 Membrane protein of unknown function; Region: DUF360; cl00850 319795003672 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331 319795003673 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 319795003674 active site 319795003675 catalytic site [active] 319795003676 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 319795003677 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 319795003678 general stress protein 13; Validated; Region: PRK08059 319795003679 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 319795003680 RNA binding site [nucleotide binding]; other site 319795003681 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 319795003682 FAD binding domain; Region: FAD_binding_2; pfam00890 319795003683 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 319795003684 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 319795003685 protein binding site [polypeptide binding]; other site 319795003686 AAK_NAGK-UC: N-Acetyl-L-glutamate kinase - uncharacterized (NAGK-UC). This domain is similar to Escherichia coli and Pseudomonas aeruginosa NAGKs which catalyze the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the...; Region: AAK_NAGK-UC; cd04251 319795003687 putative nucleotide binding site [chemical binding]; other site 319795003688 putative N-acetyl-L-glutamate binding site [chemical binding]; other site 319795003689 Major Facilitator Superfamily; Region: MFS_1; pfam07690 319795003690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 319795003691 putative substrate translocation pore; other site 319795003692 Probable transposase; Region: OrfB_IS605; pfam01385 319795003693 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 319795003694 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 319795003695 Predicted acetyltransferase [General function prediction only]; Region: COG2388 319795003696 Protein of unknown function DUF84; Region: NTPase_I-T; cl00866 319795003697 Response regulator receiver domain; Region: Response_reg; pfam00072 319795003698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 319795003699 active site 319795003700 phosphorylation site [posttranslational modification] 319795003701 intermolecular recognition site; other site 319795003702 dimerization interface [polypeptide binding]; other site 319795003703 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 319795003704 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 319795003705 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 319795003706 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 319795003707 active site 319795003708 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 319795003709 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 319795003710 adenylosuccinate lyase; Provisional; Region: PRK07492 319795003711 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 319795003712 tetramer interface [polypeptide binding]; other site 319795003713 active site 319795003714 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 319795003715 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 319795003716 motif II; other site 319795003717 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 319795003718 classical (c) SDRs; Region: SDR_c; cd05233 319795003719 NAD(P) binding site [chemical binding]; other site 319795003720 active site 319795003721 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 319795003722 Thioredoxin; Region: Thioredoxin_4; pfam13462 319795003723 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 319795003724 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 319795003725 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 319795003726 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 319795003727 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 319795003728 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 319795003729 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 319795003730 ligand binding site [chemical binding]; other site 319795003731 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 319795003732 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 319795003733 nucleotide binding pocket [chemical binding]; other site 319795003734 K-X-D-G motif; other site 319795003735 catalytic site [active] 319795003736 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 319795003737 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 319795003738 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 319795003739 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 319795003740 Dimer interface [polypeptide binding]; other site 319795003741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 319795003742 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 319795003743 putative RNA binding site [nucleotide binding]; other site 319795003744 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14173 319795003745 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 319795003746 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 319795003747 homodimer interface [polypeptide binding]; other site 319795003748 NADP binding site [chemical binding]; other site 319795003749 substrate binding site [chemical binding]; other site 319795003750 Divergent PAP2 family; Region: DUF212; pfam02681 319795003751 NADH-quinone oxidoreductase chain 15; Region: NADH_Oxid_Nqo15; pfam11497 319795003752 AAA domain; Region: AAA_17; cl17253 319795003753 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 319795003754 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 319795003755 ligand binding site [chemical binding]; other site 319795003756 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 319795003757 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 319795003758 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 319795003759 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 319795003760 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 319795003761 SxDxEG motif; other site 319795003762 active site 319795003763 metal binding site [ion binding]; metal-binding site 319795003764 homopentamer interface [polypeptide binding]; other site 319795003765 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 319795003766 CoenzymeA binding site [chemical binding]; other site 319795003767 subunit interaction site [polypeptide binding]; other site 319795003768 PHB binding site; other site 319795003769 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 319795003770 manganese transport protein MntH; Reviewed; Region: PRK00701 319795003771 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 319795003772 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 319795003773 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 319795003774 ligand binding site [chemical binding]; other site 319795003775 NAD binding site [chemical binding]; other site 319795003776 dimerization interface [polypeptide binding]; other site 319795003777 catalytic site [active] 319795003778 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 319795003779 putative L-serine binding site [chemical binding]; other site 319795003780 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 319795003781 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 319795003782 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 319795003783 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 319795003784 FOG: WD40 repeat [General function prediction only]; Region: COG2319 319795003785 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 319795003786 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 319795003787 catalytic residue [active] 319795003788 FOG: CBS domain [General function prediction only]; Region: COG0517 319795003789 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 319795003790 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 319795003791 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 319795003792 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 319795003793 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 319795003794 Ligand binding site [chemical binding]; other site 319795003795 Electron transfer flavoprotein domain; Region: ETF; pfam01012 319795003796 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 319795003797 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 319795003798 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 319795003799 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 319795003800 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 319795003801 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 319795003802 phosphate binding site [ion binding]; other site 319795003803 putative substrate binding pocket [chemical binding]; other site 319795003804 dimer interface [polypeptide binding]; other site 319795003805 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 319795003806 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 319795003807 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 319795003808 active site 319795003809 HIGH motif; other site 319795003810 KMSKS motif; other site 319795003811 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 319795003812 tRNA binding surface [nucleotide binding]; other site 319795003813 anticodon binding site; other site 319795003814 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 319795003815 dimer interface [polypeptide binding]; other site 319795003816 putative tRNA-binding site [nucleotide binding]; other site 319795003817 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 319795003818 Domain interface; other site 319795003819 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 319795003820 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 319795003821 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14603 319795003822 RuvA N terminal domain; Region: RuvA_N; pfam01330 319795003823 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 319795003824 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 319795003825 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 319795003826 active site 319795003827 ATP binding site [chemical binding]; other site 319795003828 substrate binding site [chemical binding]; other site 319795003829 activation loop (A-loop); other site 319795003830 SdiA-regulated; Region: SdiA-regulated; cd09971 319795003831 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 319795003832 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 319795003833 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 319795003834 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 319795003835 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 319795003836 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 319795003837 Walker A/P-loop; other site 319795003838 ATP binding site [chemical binding]; other site 319795003839 Q-loop/lid; other site 319795003840 ABC transporter signature motif; other site 319795003841 Walker B; other site 319795003842 D-loop; other site 319795003843 H-loop/switch region; other site 319795003844 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 319795003845 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 319795003846 Walker A/P-loop; other site 319795003847 ATP binding site [chemical binding]; other site 319795003848 Q-loop/lid; other site 319795003849 ABC transporter signature motif; other site 319795003850 Walker B; other site 319795003851 D-loop; other site 319795003852 H-loop/switch region; other site 319795003853 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 319795003854 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 319795003855 TM-ABC transporter signature motif; other site 319795003856 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 319795003857 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 319795003858 TM-ABC transporter signature motif; other site 319795003859 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 319795003860 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 319795003861 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 319795003862 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 319795003863 active site 319795003864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 319795003865 putative substrate translocation pore; other site 319795003866 FemAB family; Region: FemAB; pfam02388 319795003867 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 319795003868 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 319795003869 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 319795003870 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 319795003871 heterotetramer interface [polypeptide binding]; other site 319795003872 active site pocket [active] 319795003873 cleavage site 319795003874 Catalytic domain of Protein Kinases; Region: PKc; cd00180 319795003875 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 319795003876 active site 319795003877 ATP binding site [chemical binding]; other site 319795003878 substrate binding site [chemical binding]; other site 319795003879 activation loop (A-loop); other site 319795003880 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 319795003881 DNA polymerase III, delta subunit; Region: holA; TIGR01128 319795003882 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 319795003883 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 319795003884 catalytic residues [active] 319795003885 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 319795003886 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 319795003887 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795003888 dimer interface [polypeptide binding]; other site 319795003889 conserved gate region; other site 319795003890 putative PBP binding loops; other site 319795003891 ABC-ATPase subunit interface; other site 319795003892 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 319795003893 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795003894 putative PBP binding loops; other site 319795003895 ABC-ATPase subunit interface; other site 319795003896 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 319795003897 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 319795003898 Transcriptional regulators [Transcription]; Region: PurR; COG1609 319795003899 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 319795003900 DNA binding site [nucleotide binding] 319795003901 domain linker motif; other site 319795003902 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 319795003903 ligand binding site [chemical binding]; other site 319795003904 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 319795003905 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 319795003906 NAD(P) binding site [chemical binding]; other site 319795003907 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 319795003908 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 319795003909 substrate binding site [chemical binding]; other site 319795003910 oxyanion hole (OAH) forming residues; other site 319795003911 trimer interface [polypeptide binding]; other site 319795003912 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 319795003913 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 319795003914 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 319795003915 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 319795003916 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 319795003917 dimer interface [polypeptide binding]; other site 319795003918 active site 319795003919 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 319795003920 Low molecular weight phosphatase family; Region: LMWPc; cd00115 319795003921 active site 319795003922 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 319795003923 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 319795003924 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 319795003925 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 319795003926 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 319795003927 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 319795003928 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 319795003929 tRNA pseudouridine synthase B; Provisional; Region: PRK14122 319795003930 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 319795003931 RNA binding site [nucleotide binding]; other site 319795003932 active site 319795003933 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 319795003934 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 319795003935 RNA binding surface [nucleotide binding]; other site 319795003936 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 319795003937 active site 319795003938 Protein of unknown function (DUF423); Region: DUF423; pfam04241 319795003939 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 319795003940 MraZ protein; Region: MraZ; pfam02381 319795003941 MraZ protein; Region: MraZ; pfam02381 319795003942 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 319795003943 MraW methylase family; Region: Methyltransf_5; cl17771 319795003944 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 319795003945 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 319795003946 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 319795003947 3D domain; Region: 3D; cl01439 319795003948 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 319795003949 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 319795003950 hexamer interface [polypeptide binding]; other site 319795003951 ligand binding site [chemical binding]; other site 319795003952 putative active site [active] 319795003953 NAD(P) binding site [chemical binding]; other site 319795003954 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 319795003955 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 319795003956 putative DNA binding site [nucleotide binding]; other site 319795003957 putative Zn2+ binding site [ion binding]; other site 319795003958 AsnC family; Region: AsnC_trans_reg; pfam01037 319795003959 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 319795003960 active site 319795003961 LrgB-like family; Region: LrgB; cl00596 319795003962 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 319795003963 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 319795003964 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 319795003965 Ferredoxin [Energy production and conversion]; Region: COG1146 319795003966 4Fe-4S binding domain; Region: Fer4; cl02805 319795003967 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 319795003968 heme-binding site [chemical binding]; other site 319795003969 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 319795003970 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 319795003971 ligand binding site [chemical binding]; other site 319795003972 flexible hinge region; other site 319795003973 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 319795003974 putative switch regulator; other site 319795003975 DNA binding site [nucleotide binding] 319795003976 sequence specific DNA binding site [nucleotide binding]; other site 319795003977 putative cAMP binding site [chemical binding]; other site 319795003978 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 319795003979 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 319795003980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 319795003981 homodimer interface [polypeptide binding]; other site 319795003982 catalytic residue [active] 319795003983 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 319795003984 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 319795003985 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 319795003986 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 319795003987 dimer interface [polypeptide binding]; other site 319795003988 motif 1; other site 319795003989 active site 319795003990 motif 2; other site 319795003991 motif 3; other site 319795003992 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 319795003993 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 319795003994 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 319795003995 minor groove reading motif; other site 319795003996 helix-hairpin-helix signature motif; other site 319795003997 substrate binding pocket [chemical binding]; other site 319795003998 active site 319795003999 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 319795004000 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 319795004001 putative tRNA-binding site [nucleotide binding]; other site 319795004002 dimer interface [polypeptide binding]; other site 319795004003 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 319795004004 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 319795004005 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 319795004006 Predicted membrane protein [Function unknown]; Region: COG3431 319795004007 diaminopimelate decarboxylase; Region: lysA; TIGR01048 319795004008 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 319795004009 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 319795004010 catalytic residue [active] 319795004011 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 319795004012 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 319795004013 Ligand Binding Site [chemical binding]; other site 319795004014 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 319795004015 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 319795004016 NAD binding site [chemical binding]; other site 319795004017 ligand binding site [chemical binding]; other site 319795004018 catalytic site [active] 319795004019 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 319795004020 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 319795004021 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 319795004022 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 319795004023 active site 319795004024 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 319795004025 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 319795004026 Dimer interface [polypeptide binding]; other site 319795004027 anticodon binding site; other site 319795004028 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 319795004029 homodimer interface [polypeptide binding]; other site 319795004030 motif 1; other site 319795004031 motif 2; other site 319795004032 active site 319795004033 motif 3; other site 319795004034 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 319795004035 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 319795004036 metal binding site [ion binding]; metal-binding site 319795004037 active site 319795004038 I-site; other site 319795004039 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 319795004040 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 319795004041 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 319795004042 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 319795004043 Walker A/P-loop; other site 319795004044 ATP binding site [chemical binding]; other site 319795004045 Q-loop/lid; other site 319795004046 ABC transporter signature motif; other site 319795004047 Walker B; other site 319795004048 D-loop; other site 319795004049 H-loop/switch region; other site 319795004050 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 319795004051 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 319795004052 Walker A/P-loop; other site 319795004053 ATP binding site [chemical binding]; other site 319795004054 Q-loop/lid; other site 319795004055 ABC transporter signature motif; other site 319795004056 Walker B; other site 319795004057 D-loop; other site 319795004058 H-loop/switch region; other site 319795004059 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 319795004060 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 319795004061 TM-ABC transporter signature motif; other site 319795004062 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 319795004063 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 319795004064 TM-ABC transporter signature motif; other site 319795004065 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 319795004066 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 319795004067 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 319795004068 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 319795004069 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 319795004070 ligand binding site [chemical binding]; other site 319795004071 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 319795004072 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 319795004073 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 319795004074 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 319795004075 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 319795004076 Cytochrome c; Region: Cytochrom_C; pfam00034 319795004077 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 319795004078 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 319795004079 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 319795004080 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 319795004081 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 319795004082 active site 319795004083 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 319795004084 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 319795004085 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 319795004086 PEGA domain; Region: PEGA; pfam08308 319795004087 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 319795004088 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 319795004089 putative active site [active] 319795004090 putative CoA binding site [chemical binding]; other site 319795004091 nudix motif; other site 319795004092 metal binding site [ion binding]; metal-binding site 319795004093 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333 319795004094 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 319795004095 homodimer interface [polypeptide binding]; other site 319795004096 metal binding site [ion binding]; metal-binding site 319795004097 short chain dehydrogenase; Provisional; Region: PRK07326 319795004098 classical (c) SDR, subgroup 4; Region: SDR_c4; cd08929 319795004099 putative NAD(P) binding site [chemical binding]; other site 319795004100 homodimer interface [polypeptide binding]; other site 319795004101 active site 319795004102 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 319795004103 SmpB-tmRNA interface; other site 319795004104 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 319795004105 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 319795004106 active site 319795004107 Sporulation and spore germination; Region: Germane; pfam10646 319795004108 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 319795004109 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 319795004110 Walker A/P-loop; other site 319795004111 ATP binding site [chemical binding]; other site 319795004112 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 319795004113 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 319795004114 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 319795004115 ABC transporter signature motif; other site 319795004116 Walker B; other site 319795004117 D-loop; other site 319795004118 H-loop/switch region; other site 319795004119 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 319795004120 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 319795004121 Walker A/P-loop; other site 319795004122 ATP binding site [chemical binding]; other site 319795004123 Q-loop/lid; other site 319795004124 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 319795004125 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 319795004126 ABC transporter signature motif; other site 319795004127 Walker B; other site 319795004128 D-loop; other site 319795004129 H-loop/switch region; other site 319795004130 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 319795004131 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 319795004132 active site 319795004133 metal binding site [ion binding]; metal-binding site 319795004134 DNA binding site [nucleotide binding] 319795004135 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 319795004136 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 319795004137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 319795004138 Walker A motif; other site 319795004139 ATP binding site [chemical binding]; other site 319795004140 Walker B motif; other site 319795004141 Family description; Region: UvrD_C_2; pfam13538 319795004142 CTP synthetase; Validated; Region: pyrG; PRK05380 319795004143 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 319795004144 Catalytic site [active] 319795004145 active site 319795004146 UTP binding site [chemical binding]; other site 319795004147 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 319795004148 active site 319795004149 putative oxyanion hole; other site 319795004150 catalytic triad [active] 319795004151 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 319795004152 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 319795004153 CoA-binding site [chemical binding]; other site 319795004154 ATP-binding [chemical binding]; other site 319795004155 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 319795004156 binding surface 319795004157 TPR repeat; Region: TPR_11; pfam13414 319795004158 TPR motif; other site 319795004159 TPR repeat; Region: TPR_11; pfam13414 319795004160 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 319795004161 binding surface 319795004162 TPR motif; other site 319795004163 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 319795004164 TPR motif; other site 319795004165 TPR repeat; Region: TPR_11; pfam13414 319795004166 binding surface 319795004167 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 319795004168 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 319795004169 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 319795004170 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 319795004171 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 319795004172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 319795004173 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 319795004174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 319795004175 ATP binding site [chemical binding]; other site 319795004176 Mg2+ binding site [ion binding]; other site 319795004177 G-X-G motif; other site 319795004178 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 319795004179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 319795004180 intermolecular recognition site; other site 319795004181 active site 319795004182 dimerization interface [polypeptide binding]; other site 319795004183 Transcriptional regulator; Region: CitT; pfam12431 319795004184 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 319795004185 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 319795004186 dimer interface [polypeptide binding]; other site 319795004187 metal binding sites [ion binding]; metal-binding site 319795004188 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 319795004189 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 319795004190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 319795004191 S-adenosylmethionine binding site [chemical binding]; other site 319795004192 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 319795004193 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 319795004194 hypothetical protein; Provisional; Region: PRK10621 319795004195 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 319795004196 methionine sulfoxide reductase A; Provisional; Region: PRK14054 319795004197 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 319795004198 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795004199 DDE superfamily endonuclease; Region: DDE_4; pfam13359 319795004200 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 319795004201 MOSC domain; Region: MOSC; pfam03473 319795004202 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 319795004203 active site 319795004204 prenyltransferase; Provisional; Region: ubiA; PRK13595 319795004205 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 319795004206 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 319795004207 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 319795004208 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 319795004209 Glutamate binding site [chemical binding]; other site 319795004210 homodimer interface [polypeptide binding]; other site 319795004211 NAD binding site [chemical binding]; other site 319795004212 catalytic residues [active] 319795004213 Proline dehydrogenase; Region: Pro_dh; cl03282 319795004214 Transcriptional regulators [Transcription]; Region: GntR; COG1802 319795004215 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 319795004216 DNA-binding site [nucleotide binding]; DNA binding site 319795004217 MgtC family; Region: MgtC; pfam02308 319795004218 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 319795004219 Recombination protein O N terminal; Region: RecO_N; pfam11967 319795004220 Recombination protein O C terminal; Region: RecO_C; pfam02565 319795004221 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 319795004222 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 319795004223 substrate binding pocket [chemical binding]; other site 319795004224 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 319795004225 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 319795004226 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 319795004227 putative dimer interface [polypeptide binding]; other site 319795004228 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 319795004229 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 319795004230 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 319795004231 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 319795004232 ligand binding site; other site 319795004233 oligomer interface; other site 319795004234 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 319795004235 dimer interface [polypeptide binding]; other site 319795004236 N-terminal domain interface [polypeptide binding]; other site 319795004237 sulfate 1 binding site; other site 319795004238 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 319795004239 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 319795004240 intracellular protease, PfpI family; Region: PfpI; TIGR01382 319795004241 proposed catalytic triad [active] 319795004242 conserved cys residue [active] 319795004243 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 319795004244 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 319795004245 G1 box; other site 319795004246 putative GEF interaction site [polypeptide binding]; other site 319795004247 GTP/Mg2+ binding site [chemical binding]; other site 319795004248 Switch I region; other site 319795004249 G2 box; other site 319795004250 G3 box; other site 319795004251 Switch II region; other site 319795004252 G4 box; other site 319795004253 G5 box; other site 319795004254 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 319795004255 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 319795004256 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 319795004257 Cation efflux family; Region: Cation_efflux; pfam01545 319795004258 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 319795004259 Part of AAA domain; Region: AAA_19; pfam13245 319795004260 Family description; Region: UvrD_C_2; pfam13538 319795004261 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 319795004262 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 319795004263 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 319795004264 active site 319795004265 metal binding site [ion binding]; metal-binding site 319795004266 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864 319795004267 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 319795004268 VWA-like domain (DUF2201); Region: DUF2201; pfam09967 319795004269 MoxR-like ATPases [General function prediction only]; Region: COG0714 319795004270 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 319795004271 Walker A motif; other site 319795004272 ATP binding site [chemical binding]; other site 319795004273 Walker B motif; other site 319795004274 arginine finger; other site 319795004275 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 319795004276 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 319795004277 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 319795004278 4Fe-4S binding domain; Region: Fer4; cl02805 319795004279 Cysteine-rich domain; Region: CCG; pfam02754 319795004280 Cysteine-rich domain; Region: CCG; pfam02754 319795004281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 319795004282 TPR motif; other site 319795004283 binding surface 319795004284 TMAO/DMSO reductase; Reviewed; Region: PRK05363 319795004285 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 319795004286 Moco binding site; other site 319795004287 metal coordination site [ion binding]; other site 319795004288 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 319795004289 Protein of unknown function (DUF3208); Region: DUF3208; pfam11482 319795004290 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 319795004291 dimer interface [polypeptide binding]; other site 319795004292 active site 319795004293 Schiff base residues; other site 319795004294 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 319795004295 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 319795004296 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 319795004297 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 319795004298 catalytic loop [active] 319795004299 iron binding site [ion binding]; other site 319795004300 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 319795004301 L-aspartate oxidase; Provisional; Region: PRK06175 319795004302 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 319795004303 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 319795004304 putative Iron-sulfur protein interface [polypeptide binding]; other site 319795004305 putative proximal heme binding site [chemical binding]; other site 319795004306 putative SdhC-like subunit interface [polypeptide binding]; other site 319795004307 putative distal heme binding site [chemical binding]; other site 319795004308 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 319795004309 putative Iron-sulfur protein interface [polypeptide binding]; other site 319795004310 putative proximal heme binding site [chemical binding]; other site 319795004311 putative SdhD-like interface [polypeptide binding]; other site 319795004312 putative distal heme binding site [chemical binding]; other site 319795004313 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 319795004314 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 319795004315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 319795004316 putative substrate translocation pore; other site 319795004317 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 319795004318 putative DNA binding site [nucleotide binding]; other site 319795004319 putative Zn2+ binding site [ion binding]; other site 319795004320 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 319795004321 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 319795004322 GTP/Mg2+ binding site [chemical binding]; other site 319795004323 Switch I region; other site 319795004324 G2 box; other site 319795004325 G3 box; other site 319795004326 Switch II region; other site 319795004327 G4 box; other site 319795004328 G5 box; other site 319795004329 Nucleoside recognition; Region: Gate; pfam07670 319795004330 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 319795004331 Nucleoside recognition; Region: Gate; pfam07670 319795004332 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 319795004333 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 319795004334 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 319795004335 active site 319795004336 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 319795004337 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 319795004338 putative NAD(P) binding site [chemical binding]; other site 319795004339 active site 319795004340 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 319795004341 MutS domain III; Region: MutS_III; pfam05192 319795004342 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 319795004343 Walker A/P-loop; other site 319795004344 ATP binding site [chemical binding]; other site 319795004345 Q-loop/lid; other site 319795004346 ABC transporter signature motif; other site 319795004347 Walker B; other site 319795004348 D-loop; other site 319795004349 H-loop/switch region; other site 319795004350 Smr domain; Region: Smr; pfam01713 319795004351 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 319795004352 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 319795004353 Uncharacterized conserved protein, YhbC family [Function unknown]; Region: COG0782 319795004354 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 319795004355 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 319795004356 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 319795004357 dimer interface [polypeptide binding]; other site 319795004358 putative anticodon binding site; other site 319795004359 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 319795004360 motif 1; other site 319795004361 active site 319795004362 motif 2; other site 319795004363 motif 3; other site 319795004364 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 319795004365 putative DNA binding site [nucleotide binding]; other site 319795004366 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 319795004367 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 319795004368 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 319795004369 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 319795004370 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 319795004371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795004372 putative PBP binding loops; other site 319795004373 ABC-ATPase subunit interface; other site 319795004374 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 319795004375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795004376 dimer interface [polypeptide binding]; other site 319795004377 conserved gate region; other site 319795004378 putative PBP binding loops; other site 319795004379 ABC-ATPase subunit interface; other site 319795004380 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 319795004381 dimer interface [polypeptide binding]; other site 319795004382 phosphorylation site [posttranslational modification] 319795004383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 319795004384 ATP binding site [chemical binding]; other site 319795004385 Mg2+ binding site [ion binding]; other site 319795004386 G-X-G motif; other site 319795004387 NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; Region: NuoA; COG0838 319795004388 NADH dehydrogenase subunit B; Validated; Region: PRK06411 319795004389 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 319795004390 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 319795004391 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 319795004392 NADH dehydrogenase subunit D; Validated; Region: PRK06075 319795004393 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958 319795004394 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 319795004395 putative dimer interface [polypeptide binding]; other site 319795004396 [2Fe-2S] cluster binding site [ion binding]; other site 319795004397 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 319795004398 SLBB domain; Region: SLBB; pfam10531 319795004399 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 319795004400 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 319795004401 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 319795004402 catalytic loop [active] 319795004403 iron binding site [ion binding]; other site 319795004404 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 319795004405 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 319795004406 molybdopterin cofactor binding site; other site 319795004407 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 319795004408 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 319795004409 4Fe-4S binding domain; Region: Fer4; pfam00037 319795004410 4Fe-4S binding domain; Region: Fer4; pfam00037 319795004411 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 319795004412 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 319795004413 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 319795004414 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 319795004415 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 319795004416 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 319795004417 NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; Region: NuoN; COG1007 319795004418 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 319795004419 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 319795004420 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 319795004421 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 319795004422 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 319795004423 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795004424 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 319795004425 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 319795004426 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 319795004427 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 319795004428 Probable transposase; Region: OrfB_IS605; pfam01385 319795004429 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 319795004430 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 319795004431 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 319795004432 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 319795004433 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 319795004434 ABC transporter; Region: ABC_tran_2; pfam12848 319795004435 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 319795004436 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 319795004437 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 319795004438 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 319795004439 seryl-tRNA synthetase; Provisional; Region: PRK05431 319795004440 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 319795004441 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 319795004442 dimer interface [polypeptide binding]; other site 319795004443 active site 319795004444 motif 1; other site 319795004445 motif 2; other site 319795004446 motif 3; other site 319795004447 comF family protein; Region: comF; TIGR00201 319795004448 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 319795004449 active site 319795004450 Predicted secreted protein (DUF2259); Region: DUF2259; pfam10016 319795004451 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 319795004452 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 319795004453 Zn binding site [ion binding]; other site 319795004454 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 319795004455 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 319795004456 Zn binding site [ion binding]; other site 319795004457 Predicted esterase [General function prediction only]; Region: COG0400 319795004458 putative hydrolase; Provisional; Region: PRK11460 319795004459 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 319795004460 MarR family; Region: MarR; pfam01047 319795004461 MarR family; Region: MarR_2; cl17246 319795004462 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 319795004463 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 319795004464 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 319795004465 catalytic residue [active] 319795004466 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 319795004467 Cytochrome P450; Region: p450; cl12078 319795004468 Uncharacterized conserved protein [Function unknown]; Region: COG1432 319795004469 LabA_like proteins; Region: LabA; cd10911 319795004470 putative metal binding site [ion binding]; other site 319795004471 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 319795004472 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 319795004473 RibD C-terminal domain; Region: RibD_C; cl17279 319795004474 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 319795004475 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 319795004476 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 319795004477 active site 319795004478 Zn binding site [ion binding]; other site 319795004479 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 319795004480 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 319795004481 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 319795004482 NodB motif; other site 319795004483 active site 319795004484 catalytic site [active] 319795004485 metal binding site [ion binding]; metal-binding site 319795004486 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 319795004487 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 319795004488 NAD(P) binding site [chemical binding]; other site 319795004489 active site 319795004490 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 319795004491 Beta-lactamase; Region: Beta-lactamase; pfam00144 319795004492 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 319795004493 Chromate transporter; Region: Chromate_transp; pfam02417 319795004494 Chromate transporter; Region: Chromate_transp; pfam02417 319795004495 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09742 319795004496 CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455 319795004497 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732 319795004498 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 319795004499 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 319795004500 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749 319795004501 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 319795004502 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 319795004503 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cd09748 319795004504 CRISPR-associated protein; Region: DUF3692; pfam12469 319795004505 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 319795004506 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 319795004507 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 319795004508 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 319795004509 active site 319795004510 FMN binding site [chemical binding]; other site 319795004511 substrate binding site [chemical binding]; other site 319795004512 homotetramer interface [polypeptide binding]; other site 319795004513 catalytic residue [active] 319795004514 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 319795004515 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 319795004516 Walker A/P-loop; other site 319795004517 ATP binding site [chemical binding]; other site 319795004518 Q-loop/lid; other site 319795004519 ABC transporter signature motif; other site 319795004520 Walker B; other site 319795004521 D-loop; other site 319795004522 H-loop/switch region; other site 319795004523 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 319795004524 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 319795004525 ligand binding site [chemical binding]; other site 319795004526 flexible hinge region; other site 319795004527 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 319795004528 PUA domain; Region: PUA; cl00607 319795004529 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 319795004530 putative RNA binding site [nucleotide binding]; other site 319795004531 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 319795004532 S-adenosylmethionine binding site [chemical binding]; other site 319795004533 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 319795004534 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 319795004535 NAD(P) binding site [chemical binding]; other site 319795004536 active site 319795004537 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 319795004538 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 319795004539 generic binding surface I; other site 319795004540 generic binding surface II; other site 319795004541 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 319795004542 putative active site [active] 319795004543 putative catalytic site [active] 319795004544 putative Mg binding site IVb [ion binding]; other site 319795004545 putative phosphate binding site [ion binding]; other site 319795004546 putative DNA binding site [nucleotide binding]; other site 319795004547 putative Mg binding site IVa [ion binding]; other site 319795004548 Lamin Tail Domain; Region: LTD; pfam00932 319795004549 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 319795004550 dimer interface [polypeptide binding]; other site 319795004551 short chain dehydrogenase; Provisional; Region: PRK08219 319795004552 classical (c) SDRs; Region: SDR_c; cd05233 319795004553 NAD(P) binding site [chemical binding]; other site 319795004554 active site 319795004555 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 319795004556 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 319795004557 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 319795004558 ATP binding site [chemical binding]; other site 319795004559 putative Mg++ binding site [ion binding]; other site 319795004560 nucleotide binding region [chemical binding]; other site 319795004561 helicase superfamily c-terminal domain; Region: HELICc; smart00490 319795004562 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 319795004563 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 319795004564 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 319795004565 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 319795004566 calcium binding site 2 [ion binding]; other site 319795004567 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 319795004568 active site 319795004569 catalytic triad [active] 319795004570 calcium binding site 1 [ion binding]; other site 319795004571 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 319795004572 putative active site pocket [active] 319795004573 4-fold oligomerization interface [polypeptide binding]; other site 319795004574 metal binding residues [ion binding]; metal-binding site 319795004575 3-fold/trimer interface [polypeptide binding]; other site 319795004576 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 319795004577 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 319795004578 putative active site [active] 319795004579 oxyanion strand; other site 319795004580 catalytic triad [active] 319795004581 glycogen branching enzyme; Provisional; Region: PRK14706 319795004582 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 319795004583 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 319795004584 active site 319795004585 catalytic site [active] 319795004586 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 319795004587 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 319795004588 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 319795004589 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 319795004590 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 319795004591 four helix bundle protein; Region: TIGR02436 319795004592 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 319795004593 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 319795004594 glutamine binding [chemical binding]; other site 319795004595 catalytic triad [active] 319795004596 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 319795004597 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 319795004598 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 319795004599 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 319795004600 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 319795004601 putative DNA binding site [nucleotide binding]; other site 319795004602 putative Zn2+ binding site [ion binding]; other site 319795004603 AsnC family; Region: AsnC_trans_reg; pfam01037 319795004604 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 319795004605 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 319795004606 FeS/SAM binding site; other site 319795004607 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 319795004608 4-aminobutyrate aminotransferase; Provisional; Region: PRK05769 319795004609 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 319795004610 inhibitor-cofactor binding pocket; inhibition site 319795004611 pyridoxal 5'-phosphate binding site [chemical binding]; other site 319795004612 catalytic residue [active] 319795004613 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 319795004614 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 319795004615 catalytic triad [active] 319795004616 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 319795004617 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 319795004618 TilS substrate C-terminal domain; Region: TilS_C; smart00977 319795004619 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 319795004620 nucleoside/Zn binding site; other site 319795004621 dimer interface [polypeptide binding]; other site 319795004622 catalytic motif [active] 319795004623 gamma-glutamyl kinase; Provisional; Region: PRK05429 319795004624 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 319795004625 nucleotide binding site [chemical binding]; other site 319795004626 homotetrameric interface [polypeptide binding]; other site 319795004627 putative phosphate binding site [ion binding]; other site 319795004628 putative allosteric binding site; other site 319795004629 PUA domain; Region: PUA; pfam01472 319795004630 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 319795004631 putative catalytic cysteine [active] 319795004632 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 319795004633 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 319795004634 TPP-binding site; other site 319795004635 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 319795004636 PYR/PP interface [polypeptide binding]; other site 319795004637 dimer interface [polypeptide binding]; other site 319795004638 TPP binding site [chemical binding]; other site 319795004639 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 319795004640 PspA/IM30 family; Region: PspA_IM30; pfam04012 319795004641 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 319795004642 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 319795004643 putative active site [active] 319795004644 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 319795004645 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 319795004646 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 319795004647 hinge; other site 319795004648 active site 319795004649 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 319795004650 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 319795004651 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 319795004652 dimer interface [polypeptide binding]; other site 319795004653 FMN binding site [chemical binding]; other site 319795004654 NADPH bind site [chemical binding]; other site 319795004655 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 319795004656 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 319795004657 homodimer interface [polypeptide binding]; other site 319795004658 substrate-cofactor binding pocket; other site 319795004659 pyridoxal 5'-phosphate binding site [chemical binding]; other site 319795004660 catalytic residue [active] 319795004661 Protein of unknown function DUF99; Region: DUF99; pfam01949 319795004662 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 319795004663 DNA-binding site [nucleotide binding]; DNA binding site 319795004664 RNA-binding motif; other site 319795004665 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 319795004666 active site 319795004667 Ap6A binding site [chemical binding]; other site 319795004668 nudix motif; other site 319795004669 metal binding site [ion binding]; metal-binding site 319795004670 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 319795004671 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 319795004672 trimer interface [polypeptide binding]; other site 319795004673 putative metal binding site [ion binding]; other site 319795004674 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 319795004675 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 319795004676 Catalytic domain, repeat 1, of phospholipase D from Streptomyces Sp. Strain PMF and similar proteins; Region: PLDc_PMFPLD_like_1; cd09108 319795004677 domain interface [polypeptide binding]; other site 319795004678 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 319795004679 putative active site [active] 319795004680 catalytic site [active] 319795004681 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 319795004682 putative active site [active] 319795004683 catalytic site [active] 319795004684 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 319795004685 Predicted dehydrogenase [General function prediction only]; Region: COG5322 319795004686 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 319795004687 NAD(P) binding pocket [chemical binding]; other site 319795004688 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 319795004689 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 319795004690 ferredoxin-NADP+ reductase; Region: PLN02852 319795004691 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 319795004692 CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918 319795004693 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 319795004694 ligand binding site [chemical binding]; other site 319795004695 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 319795004696 putative switch regulator; other site 319795004697 non-specific DNA interactions [nucleotide binding]; other site 319795004698 DNA binding site [nucleotide binding] 319795004699 sequence specific DNA binding site [nucleotide binding]; other site 319795004700 putative cAMP binding site [chemical binding]; other site 319795004701 DNA gyrase subunit A; Validated; Region: PRK05560 319795004702 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 319795004703 CAP-like domain; other site 319795004704 active site 319795004705 primary dimer interface [polypeptide binding]; other site 319795004706 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 319795004707 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 319795004708 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 319795004709 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 319795004710 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 319795004711 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 319795004712 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 319795004713 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 319795004714 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 319795004715 active site 319795004716 HIGH motif; other site 319795004717 nucleotide binding site [chemical binding]; other site 319795004718 active site 319795004719 KMSKS motif; other site 319795004720 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 319795004721 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 319795004722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 319795004723 catalytic residue [active] 319795004724 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 319795004725 substrate binding site [chemical binding]; other site 319795004726 active site 319795004727 catalytic residues [active] 319795004728 heterodimer interface [polypeptide binding]; other site 319795004729 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 319795004730 dimerization interface [polypeptide binding]; other site 319795004731 metal binding site [ion binding]; metal-binding site 319795004732 sugar efflux transporter; Region: 2A0120; TIGR00899 319795004733 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 319795004734 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 319795004735 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 319795004736 substrate binding site [chemical binding]; other site 319795004737 ligand binding site [chemical binding]; other site 319795004738 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 319795004739 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 319795004740 substrate binding site [chemical binding]; other site 319795004741 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 319795004742 tartrate dehydrogenase; Region: TTC; TIGR02089 319795004743 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 319795004744 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 319795004745 active site 319795004746 metal binding site [ion binding]; metal-binding site 319795004747 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 319795004748 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 319795004749 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 319795004750 active site 319795004751 HIGH motif; other site 319795004752 KMSK motif region; other site 319795004753 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 319795004754 tRNA binding surface [nucleotide binding]; other site 319795004755 anticodon binding site; other site 319795004756 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 319795004757 Acyltransferase family; Region: Acyl_transf_3; pfam01757 319795004758 prephenate dehydrogenase; Validated; Region: PRK08507 319795004759 prephenate dehydrogenase; Validated; Region: PRK06545 319795004760 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 319795004761 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 319795004762 Ligand binding site; other site 319795004763 Putative Catalytic site; other site 319795004764 DXD motif; other site 319795004765 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 319795004766 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795004767 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 319795004768 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 319795004769 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 319795004770 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 319795004771 active site 319795004772 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 319795004773 protein binding site [polypeptide binding]; other site 319795004774 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 319795004775 putative substrate binding region [chemical binding]; other site 319795004776 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 319795004777 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 319795004778 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 319795004779 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 319795004780 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 319795004781 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 319795004782 ribosome recycling factor; Reviewed; Region: frr; PRK00083 319795004783 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 319795004784 hinge region; other site 319795004785 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 319795004786 putative nucleotide binding site [chemical binding]; other site 319795004787 uridine monophosphate binding site [chemical binding]; other site 319795004788 homohexameric interface [polypeptide binding]; other site 319795004789 elongation factor Ts; Provisional; Region: tsf; PRK09377 319795004790 UBA/TS-N domain; Region: UBA; pfam00627 319795004791 Elongation factor TS; Region: EF_TS; pfam00889 319795004792 Elongation factor TS; Region: EF_TS; pfam00889 319795004793 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 319795004794 rRNA interaction site [nucleotide binding]; other site 319795004795 S8 interaction site; other site 319795004796 putative laminin-1 binding site; other site 319795004797 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 319795004798 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 319795004799 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 319795004800 active site 319795004801 barstar interaction site; other site 319795004802 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 319795004803 putative RNAase interaction site [polypeptide binding]; other site 319795004804 UGMP family protein; Validated; Region: PRK09604 319795004805 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 319795004806 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 319795004807 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 319795004808 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 319795004809 nucleotide binding region [chemical binding]; other site 319795004810 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 319795004811 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 319795004812 Walker A/P-loop; other site 319795004813 ATP binding site [chemical binding]; other site 319795004814 Q-loop/lid; other site 319795004815 ABC transporter signature motif; other site 319795004816 Walker B; other site 319795004817 D-loop; other site 319795004818 H-loop/switch region; other site 319795004819 TOBE domain; Region: TOBE; pfam03459 319795004820 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 319795004821 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 319795004822 substrate binding pocket [chemical binding]; other site 319795004823 membrane-bound complex binding site; other site 319795004824 hinge residues; other site 319795004825 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 319795004826 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795004827 dimer interface [polypeptide binding]; other site 319795004828 conserved gate region; other site 319795004829 putative PBP binding loops; other site 319795004830 ABC-ATPase subunit interface; other site 319795004831 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 319795004832 DctM-like transporters; Region: DctM; pfam06808 319795004833 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 319795004834 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 319795004835 membrane-bound complex binding site; other site 319795004836 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 319795004837 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 319795004838 Walker A/P-loop; other site 319795004839 ATP binding site [chemical binding]; other site 319795004840 Q-loop/lid; other site 319795004841 ABC transporter signature motif; other site 319795004842 Walker B; other site 319795004843 D-loop; other site 319795004844 H-loop/switch region; other site 319795004845 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 319795004846 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 319795004847 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 319795004848 Transglycosylase; Region: Transgly; pfam00912 319795004849 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 319795004850 Response regulator receiver domain; Region: Response_reg; pfam00072 319795004851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 319795004852 active site 319795004853 phosphorylation site [posttranslational modification] 319795004854 intermolecular recognition site; other site 319795004855 dimerization interface [polypeptide binding]; other site 319795004856 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 319795004857 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 319795004858 acyl-activating enzyme (AAE) consensus motif; other site 319795004859 putative AMP binding site [chemical binding]; other site 319795004860 putative active site [active] 319795004861 putative CoA binding site [chemical binding]; other site 319795004862 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 319795004863 nucleoside/Zn binding site; other site 319795004864 dimer interface [polypeptide binding]; other site 319795004865 catalytic motif [active] 319795004866 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 319795004867 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 319795004868 substrate binding site [chemical binding]; other site 319795004869 dimer interface [polypeptide binding]; other site 319795004870 ATP binding site [chemical binding]; other site 319795004871 Protein of unknown function (DUF1999); Region: DUF1999; pfam09390 319795004872 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 319795004873 Protein of unknown function (DUF503); Region: DUF503; cl00669 319795004874 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 319795004875 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 319795004876 Catalytic site [active] 319795004877 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 319795004878 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 319795004879 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 319795004880 nucleophile elbow; other site 319795004881 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 319795004882 Catalytic domain of Protein Kinases; Region: PKc; cd00180 319795004883 active site 319795004884 ATP binding site [chemical binding]; other site 319795004885 substrate binding site [chemical binding]; other site 319795004886 activation loop (A-loop); other site 319795004887 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 319795004888 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 319795004889 EDD domain protein, DegV family; Region: DegV; TIGR00762 319795004890 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 319795004891 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 319795004892 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 319795004893 Membrane transport protein; Region: Mem_trans; cl09117 319795004894 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 319795004895 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 319795004896 oligoendopeptidase F; Region: pepF; TIGR00181 319795004897 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 319795004898 active site 319795004899 Zn binding site [ion binding]; other site 319795004900 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 319795004901 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 319795004902 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 319795004903 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 319795004904 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 319795004905 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 319795004906 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 319795004907 active site 319795004908 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 319795004909 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 319795004910 CoA-ligase; Region: Ligase_CoA; pfam00549 319795004911 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 319795004912 CoA binding domain; Region: CoA_binding; smart00881 319795004913 CoA-ligase; Region: Ligase_CoA; pfam00549 319795004914 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795004915 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 319795004916 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 319795004917 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 319795004918 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 319795004919 DNA binding site [nucleotide binding] 319795004920 active site 319795004921 Int/Topo IB signature motif; other site 319795004922 catalytic residues [active] 319795004923 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 319795004924 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 319795004925 EDD domain protein, DegV family; Region: DegV; TIGR00762 319795004926 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 319795004927 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 319795004928 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 319795004929 active site 319795004930 HIGH motif; other site 319795004931 nucleotide binding site [chemical binding]; other site 319795004932 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 319795004933 active site 319795004934 KMSKS motif; other site 319795004935 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 319795004936 tRNA binding surface [nucleotide binding]; other site 319795004937 anticodon binding site; other site 319795004938 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 319795004939 active site 319795004940 intersubunit interactions; other site 319795004941 catalytic residue [active] 319795004942 transcription termination factor Rho; Provisional; Region: rho; PRK09376 319795004943 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 319795004944 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 319795004945 RNA binding site [nucleotide binding]; other site 319795004946 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 319795004947 multimer interface [polypeptide binding]; other site 319795004948 Walker A motif; other site 319795004949 ATP binding site [chemical binding]; other site 319795004950 Walker B motif; other site 319795004951 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 319795004952 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 319795004953 Peptidase family M23; Region: Peptidase_M23; pfam01551 319795004954 Response regulator receiver domain; Region: Response_reg; pfam00072 319795004955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 319795004956 active site 319795004957 phosphorylation site [posttranslational modification] 319795004958 intermolecular recognition site; other site 319795004959 dimerization interface [polypeptide binding]; other site 319795004960 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 319795004961 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 319795004962 active site 319795004963 multimer interface [polypeptide binding]; other site 319795004964 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 319795004965 predicted active site [active] 319795004966 catalytic triad [active] 319795004967 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 319795004968 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 319795004969 nucleophilic elbow; other site 319795004970 catalytic triad; other site 319795004971 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 319795004972 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 319795004973 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 319795004974 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 319795004975 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 319795004976 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 319795004977 Bacterial SH3 domain; Region: SH3_4; pfam06347 319795004978 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 319795004979 NlpC/P60 family; Region: NLPC_P60; pfam00877 319795004980 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 319795004981 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 319795004982 active site 319795004983 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 319795004984 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 319795004985 motif II; other site 319795004986 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 319795004987 homodimer interface [polypeptide binding]; other site 319795004988 pyridoxal 5'-phosphate binding site [chemical binding]; other site 319795004989 catalytic residue [active] 319795004990 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 319795004991 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 319795004992 putative active site [active] 319795004993 catalytic triad [active] 319795004994 putative dimer interface [polypeptide binding]; other site 319795004995 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 319795004996 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 319795004997 active site 319795004998 DNA binding site [nucleotide binding] 319795004999 Int/Topo IB signature motif; other site 319795005000 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 319795005001 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 319795005002 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 319795005003 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 319795005004 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 319795005005 NAD(P) binding site [chemical binding]; other site 319795005006 catalytic residues [active] 319795005007 histidyl-tRNA synthetase; Region: hisS; TIGR00442 319795005008 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 319795005009 dimer interface [polypeptide binding]; other site 319795005010 motif 1; other site 319795005011 active site 319795005012 motif 2; other site 319795005013 motif 3; other site 319795005014 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 319795005015 anticodon binding site; other site 319795005016 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 319795005017 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 319795005018 dimer interface [polypeptide binding]; other site 319795005019 anticodon binding site; other site 319795005020 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 319795005021 homodimer interface [polypeptide binding]; other site 319795005022 motif 1; other site 319795005023 active site 319795005024 motif 2; other site 319795005025 GAD domain; Region: GAD; pfam02938 319795005026 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 319795005027 active site 319795005028 motif 3; other site 319795005029 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 319795005030 catalytic core [active] 319795005031 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 319795005032 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 319795005033 GIY-YIG motif/motif A; other site 319795005034 active site 319795005035 catalytic site [active] 319795005036 putative DNA binding site [nucleotide binding]; other site 319795005037 metal binding site [ion binding]; metal-binding site 319795005038 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 319795005039 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 319795005040 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 319795005041 active site 319795005042 aspartate kinase; Provisional; Region: PRK06291 319795005043 AAK_AK-LysC-like: Amino Acid Kinase Superfamily (AAK), AK-LysC-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive AK isoenzyme found in higher plants. The lysine-sensitive AK isoenzyme is a monofunctional...; Region: AAK_AK-LysC-like; cd04244 319795005044 putative catalytic residues [active] 319795005045 putative nucleotide binding site [chemical binding]; other site 319795005046 aspartate binding site [chemical binding]; other site 319795005047 dimer interface [polypeptide binding]; other site 319795005048 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 319795005049 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 319795005050 CopC domain; Region: CopC; pfam04234 319795005051 Domain of unkown function (DUF1775); Region: DUF1775; pfam07987 319795005052 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 319795005053 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 319795005054 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 319795005055 Phosphoglycerate kinase; Region: PGK; pfam00162 319795005056 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 319795005057 substrate binding site [chemical binding]; other site 319795005058 hinge regions; other site 319795005059 ADP binding site [chemical binding]; other site 319795005060 catalytic site [active] 319795005061 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 319795005062 triosephosphate isomerase; Provisional; Region: PRK14565 319795005063 substrate binding site [chemical binding]; other site 319795005064 dimer interface [polypeptide binding]; other site 319795005065 catalytic triad [active] 319795005066 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 319795005067 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 319795005068 putative dimer interface [polypeptide binding]; other site 319795005069 putative anticodon binding site; other site 319795005070 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 319795005071 homodimer interface [polypeptide binding]; other site 319795005072 motif 1; other site 319795005073 motif 2; other site 319795005074 active site 319795005075 motif 3; other site 319795005076 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 319795005077 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 319795005078 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 319795005079 active site 319795005080 motif I; other site 319795005081 motif II; other site 319795005082 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 319795005083 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 319795005084 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 319795005085 generic binding surface II; other site 319795005086 ssDNA binding site; other site 319795005087 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 319795005088 ATP binding site [chemical binding]; other site 319795005089 putative Mg++ binding site [ion binding]; other site 319795005090 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 319795005091 nucleotide binding region [chemical binding]; other site 319795005092 ATP-binding site [chemical binding]; other site 319795005093 short chain dehydrogenase; Provisional; Region: PRK06197 319795005094 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 319795005095 putative NAD(P) binding site [chemical binding]; other site 319795005096 active site 319795005097 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 319795005098 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 319795005099 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 319795005100 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 319795005101 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 319795005102 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 319795005103 TPR repeat; Region: TPR_11; pfam13414 319795005104 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 319795005105 binding surface 319795005106 TPR motif; other site 319795005107 TPR repeat; Region: TPR_11; pfam13414 319795005108 Uncharacterized conserved protein [Function unknown]; Region: COG0062 319795005109 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 319795005110 putative substrate binding site [chemical binding]; other site 319795005111 putative ATP binding site [chemical binding]; other site 319795005112 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 319795005113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 319795005114 Major Facilitator Superfamily; Region: MFS_1; pfam07690 319795005115 putative substrate translocation pore; other site 319795005116 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 319795005117 MarR family; Region: MarR_2; pfam12802 319795005118 Cytochrome c; Region: Cytochrom_C; pfam00034 319795005119 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 319795005120 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 319795005121 Trp docking motif [polypeptide binding]; other site 319795005122 active site 319795005123 Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144 319795005124 ATP-grasp domain; Region: ATP-grasp_4; cl17255 319795005125 lysine biosynthesis protein LysW; Region: lysW; TIGR01206 319795005126 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 319795005127 homoaconitate hydratase small subunit; Provisional; Region: PRK14023 319795005128 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 319795005129 substrate binding site [chemical binding]; other site 319795005130 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 319795005131 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 319795005132 substrate binding site [chemical binding]; other site 319795005133 ligand binding site [chemical binding]; other site 319795005134 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 319795005135 TrkA-C domain; Region: TrkA_C; pfam02080 319795005136 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 319795005137 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 319795005138 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 319795005139 B12 binding site [chemical binding]; other site 319795005140 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 319795005141 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 319795005142 FeS/SAM binding site; other site 319795005143 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 319795005144 L-aspartate oxidase; Provisional; Region: PRK06175 319795005145 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 319795005146 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 319795005147 dimerization interface [polypeptide binding]; other site 319795005148 active site 319795005149 Quinolinate synthetase A protein; Region: NadA; pfam02445 319795005150 isocitrate dehydrogenase; Validated; Region: PRK07362 319795005151 isocitrate dehydrogenase; Reviewed; Region: PRK07006 319795005152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795005153 dimer interface [polypeptide binding]; other site 319795005154 conserved gate region; other site 319795005155 putative PBP binding loops; other site 319795005156 ABC-ATPase subunit interface; other site 319795005157 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 319795005158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795005159 dimer interface [polypeptide binding]; other site 319795005160 conserved gate region; other site 319795005161 putative PBP binding loops; other site 319795005162 ABC-ATPase subunit interface; other site 319795005163 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 319795005164 Class II histocompatibility antigen, beta domain; Region: MHC_II_beta; cl03042 319795005165 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 319795005166 Protein of unknown function (DUF4127); Region: DUF4127; pfam13552 319795005167 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 319795005168 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 319795005169 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 319795005170 Glutamate binding site [chemical binding]; other site 319795005171 homodimer interface [polypeptide binding]; other site 319795005172 NAD binding site [chemical binding]; other site 319795005173 catalytic residues [active] 319795005174 Protein of unknown function (DUF664); Region: DUF664; pfam04978 319795005175 DinB superfamily; Region: DinB_2; pfam12867 319795005176 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 319795005177 active site 319795005178 ATP binding site [chemical binding]; other site 319795005179 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 319795005180 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 319795005181 inhibitor-cofactor binding pocket; inhibition site 319795005182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 319795005183 catalytic residue [active] 319795005184 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 319795005185 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 319795005186 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 319795005187 active site 319795005188 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 319795005189 Predicted permeases [General function prediction only]; Region: COG0795 319795005190 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 319795005191 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 319795005192 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 319795005193 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 319795005194 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 319795005195 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 319795005196 NodB motif; other site 319795005197 putative active site [active] 319795005198 putative catalytic site [active] 319795005199 putative Zn binding site [ion binding]; other site 319795005200 Methyltransferase domain; Region: Methyltransf_23; pfam13489 319795005201 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 319795005202 S-adenosylmethionine binding site [chemical binding]; other site 319795005203 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 319795005204 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 319795005205 active site 319795005206 catalytic residues [active] 319795005207 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 319795005208 catalytic residues [active] 319795005209 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 319795005210 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 319795005211 peptide binding site [polypeptide binding]; other site 319795005212 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 319795005213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795005214 dimer interface [polypeptide binding]; other site 319795005215 conserved gate region; other site 319795005216 putative PBP binding loops; other site 319795005217 ABC-ATPase subunit interface; other site 319795005218 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 319795005219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795005220 dimer interface [polypeptide binding]; other site 319795005221 conserved gate region; other site 319795005222 putative PBP binding loops; other site 319795005223 ABC-ATPase subunit interface; other site 319795005224 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 319795005225 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 319795005226 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 319795005227 Walker A/P-loop; other site 319795005228 ATP binding site [chemical binding]; other site 319795005229 Q-loop/lid; other site 319795005230 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 319795005231 ABC transporter signature motif; other site 319795005232 Walker B; other site 319795005233 D-loop; other site 319795005234 H-loop/switch region; other site 319795005235 PrcB C-terminal; Region: PrcB_C; pfam14343 319795005236 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 319795005237 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 319795005238 active site 319795005239 substrate-binding site [chemical binding]; other site 319795005240 metal-binding site [ion binding] 319795005241 ATP binding site [chemical binding]; other site 319795005242 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 319795005243 EamA-like transporter family; Region: EamA; pfam00892 319795005244 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 319795005245 putative homodimer interface [polypeptide binding]; other site 319795005246 putative active site pocket [active] 319795005247 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 319795005248 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 319795005249 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 319795005250 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 319795005251 DHHA1 domain; Region: DHHA1; pfam02272 319795005252 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 319795005253 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 319795005254 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 319795005255 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 319795005256 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 319795005257 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 319795005258 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 319795005259 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 319795005260 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 319795005261 dimerization interface [polypeptide binding]; other site 319795005262 ligand binding site [chemical binding]; other site 319795005263 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 319795005264 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 319795005265 TM-ABC transporter signature motif; other site 319795005266 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 319795005267 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 319795005268 TM-ABC transporter signature motif; other site 319795005269 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 319795005270 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 319795005271 Walker A/P-loop; other site 319795005272 ATP binding site [chemical binding]; other site 319795005273 Q-loop/lid; other site 319795005274 ABC transporter signature motif; other site 319795005275 Walker B; other site 319795005276 D-loop; other site 319795005277 H-loop/switch region; other site 319795005278 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 319795005279 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 319795005280 Walker A/P-loop; other site 319795005281 ATP binding site [chemical binding]; other site 319795005282 Q-loop/lid; other site 319795005283 ABC transporter signature motif; other site 319795005284 Walker B; other site 319795005285 D-loop; other site 319795005286 H-loop/switch region; other site 319795005287 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 319795005288 Clp amino terminal domain; Region: Clp_N; pfam02861 319795005289 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 319795005290 Walker A motif; other site 319795005291 ATP binding site [chemical binding]; other site 319795005292 Walker B motif; other site 319795005293 arginine finger; other site 319795005294 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 319795005295 Walker A motif; other site 319795005296 ATP binding site [chemical binding]; other site 319795005297 Walker B motif; other site 319795005298 arginine finger; other site 319795005299 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 319795005300 DNA repair protein RadA; Provisional; Region: PRK11823 319795005301 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 319795005302 Walker A motif/ATP binding site; other site 319795005303 ATP binding site [chemical binding]; other site 319795005304 Walker B motif; other site 319795005305 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 319795005306 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 319795005307 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 319795005308 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 319795005309 Clp amino terminal domain; Region: Clp_N; pfam02861 319795005310 Clp amino terminal domain; Region: Clp_N; pfam02861 319795005311 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 319795005312 Walker A motif; other site 319795005313 ATP binding site [chemical binding]; other site 319795005314 Walker B motif; other site 319795005315 arginine finger; other site 319795005316 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 319795005317 Walker A motif; other site 319795005318 ATP binding site [chemical binding]; other site 319795005319 Walker B motif; other site 319795005320 arginine finger; other site 319795005321 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 319795005322 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 319795005323 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 319795005324 Active site serine [active] 319795005325 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 319795005326 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 319795005327 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 319795005328 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 319795005329 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 319795005330 nudix motif; other site 319795005331 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 319795005332 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 319795005333 inhibitor-cofactor binding pocket; inhibition site 319795005334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 319795005335 catalytic residue [active] 319795005336 acyl-coenzyme A oxidase; Region: PLN02526 319795005337 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 319795005338 active site 319795005339 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 319795005340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 319795005341 putative substrate translocation pore; other site 319795005342 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 319795005343 NADH(P)-binding; Region: NAD_binding_10; pfam13460 319795005344 NAD binding site [chemical binding]; other site 319795005345 substrate binding site [chemical binding]; other site 319795005346 putative active site [active] 319795005347 Rrf2 family protein; Region: rrf2_super; TIGR00738 319795005348 Transcriptional regulator; Region: Rrf2; pfam02082 319795005349 Transcriptional regulator; Region: Rrf2; cl17282 319795005350 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 319795005351 nucleotide binding region [chemical binding]; other site 319795005352 ATP-binding site [chemical binding]; other site 319795005353 HRDC domain; Region: HRDC; pfam00570 319795005354 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 319795005355 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 319795005356 NADP binding site [chemical binding]; other site 319795005357 dimer interface [polypeptide binding]; other site 319795005358 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 319795005359 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 319795005360 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 319795005361 Transcriptional regulator [Transcription]; Region: LytR; COG1316 319795005362 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 319795005363 hypothetical protein; Provisional; Region: PRK14645 319795005364 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 319795005365 Sm1 motif; other site 319795005366 hexamer interface [polypeptide binding]; other site 319795005367 RNA binding site [nucleotide binding]; other site 319795005368 transcription termination factor NusA; Region: NusA; TIGR01953 319795005369 NusA N-terminal domain; Region: NusA_N; pfam08529 319795005370 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 319795005371 RNA binding site [nucleotide binding]; other site 319795005372 homodimer interface [polypeptide binding]; other site 319795005373 NusA-like KH domain; Region: KH_5; pfam13184 319795005374 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 319795005375 G-X-X-G motif; other site 319795005376 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 319795005377 putative RNA binding cleft [nucleotide binding]; other site 319795005378 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 319795005379 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 319795005380 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 319795005381 G1 box; other site 319795005382 putative GEF interaction site [polypeptide binding]; other site 319795005383 GTP/Mg2+ binding site [chemical binding]; other site 319795005384 Switch I region; other site 319795005385 G2 box; other site 319795005386 G3 box; other site 319795005387 Switch II region; other site 319795005388 G4 box; other site 319795005389 G5 box; other site 319795005390 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 319795005391 Translation-initiation factor 2; Region: IF-2; pfam11987 319795005392 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 319795005393 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 319795005394 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 319795005395 Protein export membrane protein; Region: SecD_SecF; pfam02355 319795005396 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 319795005397 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 319795005398 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 319795005399 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 319795005400 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 319795005401 Walker A/P-loop; other site 319795005402 ATP binding site [chemical binding]; other site 319795005403 Q-loop/lid; other site 319795005404 ABC transporter signature motif; other site 319795005405 Walker B; other site 319795005406 D-loop; other site 319795005407 H-loop/switch region; other site 319795005408 CcmB protein; Region: CcmB; cl17444 319795005409 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 319795005410 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 319795005411 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 319795005412 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 319795005413 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 319795005414 catalytic residues [active] 319795005415 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 319795005416 TPR repeat; Region: TPR_11; pfam13414 319795005417 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 319795005418 TPR motif; other site 319795005419 binding surface 319795005420 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 319795005421 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 319795005422 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 319795005423 iron-sulfur cluster [ion binding]; other site 319795005424 [2Fe-2S] cluster binding site [ion binding]; other site 319795005425 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 319795005426 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 319795005427 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 319795005428 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 319795005429 putative active site [active] 319795005430 putative catalytic site [active] 319795005431 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 319795005432 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 319795005433 active site 319795005434 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 319795005435 catalytic tetrad [active] 319795005436 Saccharomyces cerevisiae homocitrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_HCS; cd07948 319795005437 homocitrate synthase; Region: LysS_fung_arch; TIGR02146 319795005438 active site 319795005439 catalytic residues [active] 319795005440 metal binding site [ion binding]; metal-binding site 319795005441 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 319795005442 benzoate transporter; Region: benE; TIGR00843 319795005443 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 319795005444 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 319795005445 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 319795005446 catalytic residue [active] 319795005447 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 319795005448 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 319795005449 catalytic residues [active] 319795005450 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 319795005451 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 319795005452 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 319795005453 tetramer (dimer of dimers) interface [polypeptide binding]; other site 319795005454 active site 319795005455 dimer interface [polypeptide binding]; other site 319795005456 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 319795005457 intersubunit interface [polypeptide binding]; other site 319795005458 active site 319795005459 catalytic residue [active] 319795005460 Maf-like protein; Provisional; Region: PRK14361 319795005461 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 319795005462 active site 319795005463 dimer interface [polypeptide binding]; other site 319795005464 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 319795005465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 319795005466 active site 319795005467 phosphorylation site [posttranslational modification] 319795005468 intermolecular recognition site; other site 319795005469 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 319795005470 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 319795005471 dimer interface [polypeptide binding]; other site 319795005472 phosphorylation site [posttranslational modification] 319795005473 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 319795005474 ATP binding site [chemical binding]; other site 319795005475 Mg2+ binding site [ion binding]; other site 319795005476 G-X-G motif; other site 319795005477 CHASE domain; Region: CHASE; pfam03924 319795005478 PAS domain S-box; Region: sensory_box; TIGR00229 319795005479 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 319795005480 putative active site [active] 319795005481 heme pocket [chemical binding]; other site 319795005482 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 319795005483 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 319795005484 putative active site [active] 319795005485 heme pocket [chemical binding]; other site 319795005486 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 319795005487 putative active site [active] 319795005488 heme pocket [chemical binding]; other site 319795005489 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 319795005490 dimer interface [polypeptide binding]; other site 319795005491 phosphorylation site [posttranslational modification] 319795005492 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 319795005493 ATP binding site [chemical binding]; other site 319795005494 Mg2+ binding site [ion binding]; other site 319795005495 G-X-G motif; other site 319795005496 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 319795005497 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 319795005498 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 319795005499 NAD(P) binding site [chemical binding]; other site 319795005500 shikimate binding site; other site 319795005501 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 319795005502 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245 319795005503 PhoH-like protein; Region: PhoH; pfam02562 319795005504 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 319795005505 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 319795005506 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 319795005507 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 319795005508 ligand binding site [chemical binding]; other site 319795005509 flexible hinge region; other site 319795005510 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 319795005511 non-specific DNA interactions [nucleotide binding]; other site 319795005512 DNA binding site [nucleotide binding] 319795005513 sequence specific DNA binding site [nucleotide binding]; other site 319795005514 putative cAMP binding site [chemical binding]; other site 319795005515 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 319795005516 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 319795005517 Protein of unknown function (DUF402); Region: DUF402; cl00979 319795005518 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 319795005519 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 319795005520 Peptidase family U32; Region: Peptidase_U32; pfam01136 319795005521 Collagenase; Region: DUF3656; pfam12392 319795005522 Quinolinate phosphoribosyl transferase, C-terminal domain; Region: QRPTase_C; pfam01729 319795005523 Peptidase family U32; Region: Peptidase_U32; cl03113 319795005524 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 319795005525 Ligand Binding Site [chemical binding]; other site 319795005526 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 319795005527 active site residue [active] 319795005528 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 319795005529 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 319795005530 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 319795005531 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 319795005532 active site 319795005533 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 319795005534 Domain of unknown function DUF21; Region: DUF21; pfam01595 319795005535 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 319795005536 Transporter associated domain; Region: CorC_HlyC; smart01091 319795005537 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 319795005538 active site 319795005539 catalytic motif [active] 319795005540 Zn binding site [ion binding]; other site 319795005541 isocitrate lyase; Provisional; Region: PRK15063 319795005542 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 319795005543 tetramer interface [polypeptide binding]; other site 319795005544 active site 319795005545 Mg2+/Mn2+ binding site [ion binding]; other site 319795005546 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 319795005547 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 319795005548 motif II; other site 319795005549 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 319795005550 DHH family; Region: DHH; pfam01368 319795005551 DHHA1 domain; Region: DHHA1; pfam02272 319795005552 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 319795005553 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 319795005554 EDD domain protein, DegV family; Region: DegV; TIGR00762 319795005555 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 319795005556 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 319795005557 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 319795005558 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 319795005559 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 319795005560 active site 319795005561 homodimer interface [polypeptide binding]; other site 319795005562 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 319795005563 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 319795005564 Mg++ binding site [ion binding]; other site 319795005565 putative catalytic motif [active] 319795005566 substrate binding site [chemical binding]; other site 319795005567 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 319795005568 active site 319795005569 Phosphotransferase enzyme family; Region: APH; pfam01636 319795005570 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 319795005571 active site 319795005572 substrate binding site [chemical binding]; other site 319795005573 ATP binding site [chemical binding]; other site 319795005574 GAF domain; Region: GAF_3; pfam13492 319795005575 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 319795005576 Zn2+ binding site [ion binding]; other site 319795005577 Mg2+ binding site [ion binding]; other site 319795005578 Flagellin N-methylase; Region: FliB; cl00497 319795005579 DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626 319795005580 putative ligand binding site [chemical binding]; other site 319795005581 EamA-like transporter family; Region: EamA; pfam00892 319795005582 EamA-like transporter family; Region: EamA; pfam00892 319795005583 DDE superfamily endonuclease; Region: DDE_5; pfam13546 319795005584 Protein of unknown function (DUF4127); Region: DUF4127; pfam13552 319795005585 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 319795005586 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 319795005587 active site 319795005588 dimer interface [polypeptide binding]; other site 319795005589 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 319795005590 dimer interface [polypeptide binding]; other site 319795005591 active site 319795005592 putative acyltransferase; Provisional; Region: PRK05790 319795005593 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 319795005594 dimer interface [polypeptide binding]; other site 319795005595 active site 319795005596 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 319795005597 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 319795005598 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 319795005599 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 319795005600 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 319795005601 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 319795005602 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 319795005603 Zn2+ binding site [ion binding]; other site 319795005604 Mg2+ binding site [ion binding]; other site 319795005605 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 319795005606 synthetase active site [active] 319795005607 NTP binding site [chemical binding]; other site 319795005608 metal binding site [ion binding]; metal-binding site 319795005609 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 319795005610 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 319795005611 Ion channel; Region: Ion_trans_2; pfam07885 319795005612 Helix-turn-helix domain; Region: HTH_17; pfam12728 319795005613 Protein of unknown function (DUF554); Region: DUF554; cl00784 319795005614 SdpI/YhfL protein family; Region: SdpI; pfam13630 319795005615 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 319795005616 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 319795005617 dimerization interface [polypeptide binding]; other site 319795005618 putative DNA binding site [nucleotide binding]; other site 319795005619 putative Zn2+ binding site [ion binding]; other site 319795005620 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 319795005621 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 319795005622 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 319795005623 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 319795005624 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 319795005625 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 319795005626 dimer interface [polypeptide binding]; other site 319795005627 active site 319795005628 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 319795005629 catalytic residues [active] 319795005630 substrate binding site [chemical binding]; other site 319795005631 2-phosphosulfolactate phosphatase; Provisional; Region: PRK14100 319795005632 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 319795005633 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 319795005634 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 319795005635 substrate binding site [chemical binding]; other site 319795005636 hexamer interface [polypeptide binding]; other site 319795005637 metal binding site [ion binding]; metal-binding site 319795005638 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 319795005639 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 319795005640 active site 319795005641 substrate binding site [chemical binding]; other site 319795005642 coenzyme B12 binding site [chemical binding]; other site 319795005643 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 319795005644 B12 binding site [chemical binding]; other site 319795005645 cobalt ligand [ion binding]; other site 319795005646 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 319795005647 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 319795005648 Walker A; other site 319795005649 Ferritin-like domain; Region: Ferritin_2; pfam13668 319795005650 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 319795005651 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 319795005652 active site 319795005653 nucleotide binding site [chemical binding]; other site 319795005654 HIGH motif; other site 319795005655 KMSKS motif; other site 319795005656 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 319795005657 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 319795005658 active site 319795005659 benzoate transport; Region: 2A0115; TIGR00895 319795005660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 319795005661 putative substrate translocation pore; other site 319795005662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 319795005663 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 319795005664 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 319795005665 homodimer interface [polypeptide binding]; other site 319795005666 NAD binding pocket [chemical binding]; other site 319795005667 ATP binding pocket [chemical binding]; other site 319795005668 Mg binding site [ion binding]; other site 319795005669 active-site loop [active] 319795005670 short chain dehydrogenase; Provisional; Region: PRK05872 319795005671 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 319795005672 NAD(P) binding site [chemical binding]; other site 319795005673 active site 319795005674 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 319795005675 nucleotide binding site/active site [active] 319795005676 HIT family signature motif; other site 319795005677 catalytic residue [active] 319795005678 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 319795005679 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 319795005680 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 319795005681 motif II; other site 319795005682 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 319795005683 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 319795005684 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 319795005685 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 319795005686 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 319795005687 putative L-serine binding site [chemical binding]; other site 319795005688 amidase; Provisional; Region: PRK06828 319795005689 Amidase; Region: Amidase; cl11426 319795005690 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 319795005691 Prephenate dehydratase; Region: PDT; pfam00800 319795005692 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 319795005693 putative L-Phe binding site [chemical binding]; other site 319795005694 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 319795005695 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 319795005696 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 319795005697 substrate binding pocket [chemical binding]; other site 319795005698 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 319795005699 B12 binding site [chemical binding]; other site 319795005700 cobalt ligand [ion binding]; other site 319795005701 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 319795005702 5,10-methylenetetrahydrofolate reductase [Amino acid transport and metabolism]; Region: MetF; COG0685 319795005703 FAD binding site [chemical binding]; other site 319795005704 Uncharacterized conserved protein [Function unknown]; Region: COG5316 319795005705 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 319795005706 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 319795005707 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 319795005708 Walker A/P-loop; other site 319795005709 ATP binding site [chemical binding]; other site 319795005710 Q-loop/lid; other site 319795005711 ABC transporter signature motif; other site 319795005712 Walker B; other site 319795005713 D-loop; other site 319795005714 H-loop/switch region; other site 319795005715 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 319795005716 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 319795005717 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 319795005718 Walker A/P-loop; other site 319795005719 ATP binding site [chemical binding]; other site 319795005720 Q-loop/lid; other site 319795005721 ABC transporter signature motif; other site 319795005722 Walker B; other site 319795005723 D-loop; other site 319795005724 H-loop/switch region; other site 319795005725 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 319795005726 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 319795005727 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 319795005728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795005729 dimer interface [polypeptide binding]; other site 319795005730 conserved gate region; other site 319795005731 putative PBP binding loops; other site 319795005732 ABC-ATPase subunit interface; other site 319795005733 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 319795005734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795005735 dimer interface [polypeptide binding]; other site 319795005736 conserved gate region; other site 319795005737 ABC-ATPase subunit interface; other site 319795005738 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 319795005739 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 319795005740 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 319795005741 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 319795005742 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 319795005743 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 319795005744 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 319795005745 DNA binding residues [nucleotide binding] 319795005746 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 319795005747 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 319795005748 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 319795005749 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 319795005750 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 319795005751 RNHCP domain; Region: RNHCP; pfam12647 319795005752 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 319795005753 Amidase; Region: Amidase; cl11426 319795005754 Protein of unknown function (DUF3680); Region: DUF3680; pfam12441 319795005755 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 319795005756 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 319795005757 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 319795005758 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 319795005759 non-specific DNA binding site [nucleotide binding]; other site 319795005760 salt bridge; other site 319795005761 sequence-specific DNA binding site [nucleotide binding]; other site 319795005762 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 319795005763 Catalytic site [active] 319795005764 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 319795005765 catalytic residues [active] 319795005766 catalytic nucleophile [active] 319795005767 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 319795005768 Recombinase; Region: Recombinase; pfam07508 319795005769 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 319795005770 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14334 319795005771 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 319795005772 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 319795005773 FeS/SAM binding site; other site 319795005774 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 319795005775 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 319795005776 intersubunit interface [polypeptide binding]; other site 319795005777 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 319795005778 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 319795005779 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 319795005780 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 319795005781 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 319795005782 Walker A/P-loop; other site 319795005783 ATP binding site [chemical binding]; other site 319795005784 Q-loop/lid; other site 319795005785 ABC transporter signature motif; other site 319795005786 Walker B; other site 319795005787 D-loop; other site 319795005788 H-loop/switch region; other site 319795005789 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 319795005790 PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393 319795005791 active site 319795005792 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 319795005793 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 319795005794 FtsX-like permease family; Region: FtsX; pfam02687 319795005795 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 319795005796 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 319795005797 Walker A/P-loop; other site 319795005798 ATP binding site [chemical binding]; other site 319795005799 Q-loop/lid; other site 319795005800 ABC transporter signature motif; other site 319795005801 Walker B; other site 319795005802 D-loop; other site 319795005803 H-loop/switch region; other site 319795005804 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 319795005805 alanine racemase; Region: alr; TIGR00492 319795005806 active site 319795005807 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 319795005808 dimer interface [polypeptide binding]; other site 319795005809 substrate binding site [chemical binding]; other site 319795005810 catalytic residues [active] 319795005811 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 319795005812 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 319795005813 homotetramer interface [polypeptide binding]; other site 319795005814 FMN binding site [chemical binding]; other site 319795005815 homodimer contacts [polypeptide binding]; other site 319795005816 putative active site [active] 319795005817 putative substrate binding site [chemical binding]; other site 319795005818 butyrate kinase; Provisional; Region: PRK03011 319795005819 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 319795005820 30S subunit binding site; other site 319795005821 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 319795005822 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 319795005823 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 319795005824 Walker A/P-loop; other site 319795005825 ATP binding site [chemical binding]; other site 319795005826 Q-loop/lid; other site 319795005827 ABC transporter signature motif; other site 319795005828 Walker B; other site 319795005829 D-loop; other site 319795005830 H-loop/switch region; other site 319795005831 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 319795005832 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 319795005833 hinge; other site 319795005834 active site 319795005835 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 319795005836 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 319795005837 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 319795005838 NlpC/P60 family; Region: NLPC_P60; pfam00877 319795005839 H+ Antiporter protein; Region: 2A0121; TIGR00900 319795005840 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 319795005841 putative substrate translocation pore; other site 319795005842 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 319795005843 transmembrane helices; other site 319795005844 TrkA-C domain; Region: TrkA_C; pfam02080 319795005845 TrkA-C domain; Region: TrkA_C; pfam02080 319795005846 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 319795005847 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 319795005848 acetyl-lysine deacetylase; Provisional; Region: PRK04443 319795005849 M20 Peptidase acetylornithine deacetylase/acetyl-lysine deacetylase; Region: M20_ArgE_LysK; cd05653 319795005850 metal binding site [ion binding]; metal-binding site 319795005851 putative dimer interface [polypeptide binding]; other site 319795005852 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 319795005853 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 319795005854 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 319795005855 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 319795005856 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 319795005857 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 319795005858 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 319795005859 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 319795005860 Catalytic domain of Protein Kinases; Region: PKc; cd00180 319795005861 active site 319795005862 ATP binding site [chemical binding]; other site 319795005863 substrate binding site [chemical binding]; other site 319795005864 activation loop (A-loop); other site 319795005865 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 319795005866 Trp docking motif [polypeptide binding]; other site 319795005867 FOG: WD40-like repeat [Function unknown]; Region: COG1520 319795005868 active site 319795005869 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 319795005870 Trp docking motif [polypeptide binding]; other site 319795005871 active site 319795005872 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 319795005873 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 319795005874 recombination factor protein RarA; Reviewed; Region: PRK13342 319795005875 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 319795005876 Walker A motif; other site 319795005877 ATP binding site [chemical binding]; other site 319795005878 Walker B motif; other site 319795005879 arginine finger; other site 319795005880 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 319795005881 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 319795005882 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 319795005883 active site 319795005884 catalytic tetrad [active] 319795005885 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 319795005886 active site 319795005887 dimer interface [polypeptide binding]; other site 319795005888 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 319795005889 Rrf2 family protein; Region: rrf2_super; TIGR00738 319795005890 Transcriptional regulator; Region: Rrf2; pfam02082 319795005891 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 319795005892 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 319795005893 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 319795005894 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 319795005895 ligand-binding site [chemical binding]; other site 319795005896 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 319795005897 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 319795005898 Active Sites [active] 319795005899 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 319795005900 ATP-sulfurylase; Region: ATPS; cd00517 319795005901 active site 319795005902 HXXH motif; other site 319795005903 flexible loop; other site 319795005904 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 319795005905 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 319795005906 substrate binding pocket [chemical binding]; other site 319795005907 membrane-bound complex binding site; other site 319795005908 hinge residues; other site 319795005909 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 319795005910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795005911 dimer interface [polypeptide binding]; other site 319795005912 conserved gate region; other site 319795005913 putative PBP binding loops; other site 319795005914 ABC-ATPase subunit interface; other site 319795005915 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 319795005916 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 319795005917 Walker A/P-loop; other site 319795005918 ATP binding site [chemical binding]; other site 319795005919 Q-loop/lid; other site 319795005920 ABC transporter signature motif; other site 319795005921 Walker B; other site 319795005922 D-loop; other site 319795005923 H-loop/switch region; other site 319795005924 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 319795005925 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 319795005926 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 319795005927 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 319795005928 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 319795005929 acetylornithine aminotransferase; Provisional; Region: PRK02627 319795005930 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 319795005931 inhibitor-cofactor binding pocket; inhibition site 319795005932 pyridoxal 5'-phosphate binding site [chemical binding]; other site 319795005933 catalytic residue [active] 319795005934 HerA helicase [Replication, recombination, and repair]; Region: COG0433 319795005935 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2380 319795005936 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 319795005937 CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918 319795005938 ligand binding site [chemical binding]; other site 319795005939 flexible hinge region; other site 319795005940 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 319795005941 non-specific DNA interactions [nucleotide binding]; other site 319795005942 DNA binding site [nucleotide binding] 319795005943 sequence specific DNA binding site [nucleotide binding]; other site 319795005944 putative cAMP binding site [chemical binding]; other site 319795005945 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 319795005946 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 319795005947 putative active site [active] 319795005948 Zn binding site [ion binding]; other site 319795005949 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 319795005950 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 319795005951 putative substrate binding site [chemical binding]; other site 319795005952 putative ATP binding site [chemical binding]; other site 319795005953 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 319795005954 tetramerization interface [polypeptide binding]; other site 319795005955 active site 319795005956 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 319795005957 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 319795005958 Domain of unknown function (DUF814); Region: DUF814; pfam05670 319795005959 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 319795005960 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 319795005961 DNA binding residues [nucleotide binding] 319795005962 drug binding residues [chemical binding]; other site 319795005963 dimer interface [polypeptide binding]; other site 319795005964 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 319795005965 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 319795005966 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 319795005967 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 319795005968 Surface antigen; Region: Bac_surface_Ag; pfam01103 319795005969 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 319795005970 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 319795005971 catalytic residue [active] 319795005972 DivIVA protein; Region: DivIVA; pfam05103 319795005973 DivIVA domain; Region: DivI1A_domain; TIGR03544 319795005974 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 319795005975 synthetase active site [active] 319795005976 NTP binding site [chemical binding]; other site 319795005977 metal binding site [ion binding]; metal-binding site 319795005978 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 319795005979 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 319795005980 DNA-binding site [nucleotide binding]; DNA binding site 319795005981 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 319795005982 pyridoxal 5'-phosphate binding site [chemical binding]; other site 319795005983 homodimer interface [polypeptide binding]; other site 319795005984 catalytic residue [active] 319795005985 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 319795005986 recombination regulator RecX; Provisional; Region: recX; PRK14137 319795005987 RecX family; Region: RecX; pfam02631 319795005988 Predicted phosphohydrolase [General function prediction only]; Region: COG1768 319795005989 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 319795005990 CCC1-related family of proteins; Region: CCC1_like; cl00278 319795005991 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 319795005992 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 319795005993 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 319795005994 HlyD family secretion protein; Region: HlyD_3; pfam13437 319795005995 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 319795005996 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 319795005997 signal recognition particle protein; Provisional; Region: PRK10867 319795005998 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 319795005999 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 319795006000 P loop; other site 319795006001 GTP binding site [chemical binding]; other site 319795006002 Signal peptide binding domain; Region: SRP_SPB; pfam02978 319795006003 putative acyltransferase; Provisional; Region: PRK05790 319795006004 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 319795006005 dimer interface [polypeptide binding]; other site 319795006006 active site 319795006007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 319795006008 hypothetical protein; Provisional; Region: PRK07758 319795006009 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 319795006010 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 319795006011 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 319795006012 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 319795006013 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 319795006014 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 319795006015 CAAX protease self-immunity; Region: Abi; pfam02517 319795006016 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 319795006017 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 319795006018 tetramer interface [polypeptide binding]; other site 319795006019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 319795006020 catalytic residue [active] 319795006021 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 319795006022 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 319795006023 elongation factor G; Reviewed; Region: PRK12740 319795006024 G1 box; other site 319795006025 putative GEF interaction site [polypeptide binding]; other site 319795006026 GTP/Mg2+ binding site [chemical binding]; other site 319795006027 Switch I region; other site 319795006028 G2 box; other site 319795006029 G3 box; other site 319795006030 Switch II region; other site 319795006031 G4 box; other site 319795006032 G5 box; other site 319795006033 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 319795006034 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 319795006035 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 319795006036 PRC-barrel domain; Region: PRC; pfam05239 319795006037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 319795006038 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 319795006039 Uncharacterized conserved protein [Function unknown]; Region: COG4121 319795006040 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 319795006041 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 319795006042 tartrate dehydrogenase; Region: TTC; TIGR02089 319795006043 Predicted membrane protein [Function unknown]; Region: COG2323 319795006044 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK14655 319795006045 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 319795006046 Mg++ binding site [ion binding]; other site 319795006047 putative catalytic motif [active] 319795006048 putative substrate binding site [chemical binding]; other site 319795006049 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 319795006050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 319795006051 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 319795006052 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 319795006053 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 319795006054 dimerization interface [polypeptide binding]; other site 319795006055 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 319795006056 Cytochrome c553 [Energy production and conversion]; Region: COG2863 319795006057 Cytochrome c; Region: Cytochrom_C; cl11414 319795006058 Protein of unknown function (DUF968); Region: DUF968; pfam06147 319795006059 Protein of unknown function (DUF1517); Region: DUF1517; cl01807 319795006060 Uncharacterized conserved protein [Function unknown]; Region: COG2127 319795006061 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 319795006062 Clp amino terminal domain; Region: Clp_N; pfam02861 319795006063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 319795006064 Walker A motif; other site 319795006065 ATP binding site [chemical binding]; other site 319795006066 Walker B motif; other site 319795006067 arginine finger; other site 319795006068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 319795006069 Walker A motif; other site 319795006070 ATP binding site [chemical binding]; other site 319795006071 Walker B motif; other site 319795006072 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 319795006073 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 319795006074 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 319795006075 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 319795006076 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 319795006077 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 319795006078 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 319795006079 C-terminal peptidase (prc); Region: prc; TIGR00225 319795006080 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 319795006081 Catalytic dyad [active] 319795006082 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 319795006083 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 319795006084 Walker A/P-loop; other site 319795006085 ATP binding site [chemical binding]; other site 319795006086 Q-loop/lid; other site 319795006087 ABC transporter signature motif; other site 319795006088 Walker B; other site 319795006089 D-loop; other site 319795006090 H-loop/switch region; other site 319795006091 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 319795006092 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 319795006093 Peptidase family M23; Region: Peptidase_M23; pfam01551 319795006094 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 319795006095 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 319795006096 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 319795006097 G-X-X-G motif; other site 319795006098 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13829 319795006099 RimM N-terminal domain; Region: RimM; pfam01782 319795006100 PRC-barrel domain; Region: PRC; pfam05239 319795006101 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 319795006102 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 319795006103 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 319795006104 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 319795006105 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 319795006106 putative active site [active] 319795006107 putative substrate binding site [chemical binding]; other site 319795006108 putative cosubstrate binding site; other site 319795006109 catalytic site [active] 319795006110 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 319795006111 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 319795006112 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 319795006113 putative active site [active] 319795006114 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 319795006115 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 319795006116 ATP binding site [chemical binding]; other site 319795006117 putative Mg++ binding site [ion binding]; other site 319795006118 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 319795006119 nucleotide binding region [chemical binding]; other site 319795006120 ATP-binding site [chemical binding]; other site 319795006121 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 319795006122 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 319795006123 G1 box; other site 319795006124 putative GEF interaction site [polypeptide binding]; other site 319795006125 GTP/Mg2+ binding site [chemical binding]; other site 319795006126 Switch I region; other site 319795006127 G2 box; other site 319795006128 G3 box; other site 319795006129 Switch II region; other site 319795006130 G4 box; other site 319795006131 G5 box; other site 319795006132 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 319795006133 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 319795006134 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 319795006135 phosphate binding site [ion binding]; other site 319795006136 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 319795006137 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 319795006138 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 319795006139 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 319795006140 DNA binding residues [nucleotide binding] 319795006141 dimerization interface [polypeptide binding]; other site 319795006142 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 319795006143 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 319795006144 putative RNA binding site [nucleotide binding]; other site 319795006145 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 319795006146 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 319795006147 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 319795006148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 319795006149 putative substrate translocation pore; other site 319795006150 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 319795006151 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 319795006152 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 319795006153 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795006154 dimer interface [polypeptide binding]; other site 319795006155 conserved gate region; other site 319795006156 putative PBP binding loops; other site 319795006157 ABC-ATPase subunit interface; other site 319795006158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 319795006159 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 319795006160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795006161 dimer interface [polypeptide binding]; other site 319795006162 conserved gate region; other site 319795006163 putative PBP binding loops; other site 319795006164 ABC-ATPase subunit interface; other site 319795006165 Protein of unknown function (DUF524); Region: DUF524; pfam04411 319795006166 AAA domain; Region: AAA_25; pfam13481 319795006167 Domain of unknown function DUF11; Region: DUF11; pfam01345 319795006168 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 319795006169 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 319795006170 putative active site [active] 319795006171 catalytic site [active] 319795006172 putative metal binding site [ion binding]; other site 319795006173 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 319795006174 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 319795006175 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 319795006176 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 319795006177 active site 319795006178 dimer interface [polypeptide binding]; other site 319795006179 motif 1; other site 319795006180 motif 2; other site 319795006181 motif 3; other site 319795006182 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 319795006183 anticodon binding site; other site 319795006184 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 319795006185 catalytic residues [active] 319795006186 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 319795006187 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 319795006188 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 319795006189 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 319795006190 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 319795006191 hypothetical protein; Validated; Region: PRK00153 319795006192 recombination protein RecR; Reviewed; Region: recR; PRK00076 319795006193 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 319795006194 RecR protein; Region: RecR; pfam02132 319795006195 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 319795006196 putative active site [active] 319795006197 putative metal-binding site [ion binding]; other site 319795006198 tetramer interface [polypeptide binding]; other site 319795006199 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 319795006200 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 319795006201 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 319795006202 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 319795006203 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 319795006204 Peptidase family M23; Region: Peptidase_M23; pfam01551 319795006205 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 319795006206 putative active site [active] 319795006207 dimerization interface [polypeptide binding]; other site 319795006208 putative tRNAtyr binding site [nucleotide binding]; other site 319795006209 Domain of unknown function (DUF1844); Region: DUF1844; pfam08899 319795006210 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 319795006211 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 319795006212 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 319795006213 DNA binding residues [nucleotide binding] 319795006214 FUN14 family; Region: FUN14; pfam04930 319795006215 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 319795006216 dimerization interface [polypeptide binding]; other site 319795006217 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 319795006218 dimer interface [polypeptide binding]; other site 319795006219 phosphorylation site [posttranslational modification] 319795006220 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 319795006221 ATP binding site [chemical binding]; other site 319795006222 Mg2+ binding site [ion binding]; other site 319795006223 G-X-G motif; other site 319795006224 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 319795006225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 319795006226 active site 319795006227 phosphorylation site [posttranslational modification] 319795006228 intermolecular recognition site; other site 319795006229 dimerization interface [polypeptide binding]; other site 319795006230 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 319795006231 DNA binding site [nucleotide binding] 319795006232 Outer membrane efflux protein; Region: OEP; pfam02321 319795006233 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 319795006234 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 319795006235 Glycoprotease family; Region: Peptidase_M22; pfam00814 319795006236 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 319795006237 dimer interface [polypeptide binding]; other site 319795006238 Citrate synthase; Region: Citrate_synt; pfam00285 319795006239 active site 319795006240 coenzyme A binding site [chemical binding]; other site 319795006241 citrylCoA binding site [chemical binding]; other site 319795006242 oxalacetate/citrate binding site [chemical binding]; other site 319795006243 catalytic triad [active] 319795006244 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 319795006245 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 319795006246 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 319795006247 active site 319795006248 metal binding site [ion binding]; metal-binding site 319795006249 homotetramer interface [polypeptide binding]; other site 319795006250 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 319795006251 Trp docking motif [polypeptide binding]; other site 319795006252 PQQ-like domain; Region: PQQ_2; pfam13360 319795006253 active site 319795006254 Putative cyclase; Region: Cyclase; cl00814 319795006255 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 319795006256 kynureninase; Region: kynureninase; TIGR01814 319795006257 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 319795006258 catalytic residue [active] 319795006259 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 319795006260 active site 319795006261 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 319795006262 aromatic arch; other site 319795006263 DCoH dimer interaction site [polypeptide binding]; other site 319795006264 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 319795006265 DCoH tetramer interaction site [polypeptide binding]; other site 319795006266 substrate binding site [chemical binding]; other site 319795006267 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 319795006268 MutS domain I; Region: MutS_I; pfam01624 319795006269 MutS domain II; Region: MutS_II; pfam05188 319795006270 MutS domain III; Region: MutS_III; pfam05192 319795006271 MutS domain V; Region: MutS_V; pfam00488 319795006272 Walker A/P-loop; other site 319795006273 ATP binding site [chemical binding]; other site 319795006274 Q-loop/lid; other site 319795006275 ABC transporter signature motif; other site 319795006276 Walker B; other site 319795006277 D-loop; other site 319795006278 H-loop/switch region; other site 319795006279 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 319795006280 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 319795006281 ATP binding site [chemical binding]; other site 319795006282 Mg2+ binding site [ion binding]; other site 319795006283 G-X-G motif; other site 319795006284 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 319795006285 ATP binding site [chemical binding]; other site 319795006286 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 319795006287 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 319795006288 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 319795006289 HIGH motif; other site 319795006290 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 319795006291 active site 319795006292 KMSKS motif; other site 319795006293 FOG: WD40 repeat [General function prediction only]; Region: COG2319 319795006294 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 319795006295 structural tetrad; other site 319795006296 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 319795006297 B12 binding site [chemical binding]; other site 319795006298 cobalt ligand [ion binding]; other site 319795006299 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 319795006300 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 319795006301 ATP binding site [chemical binding]; other site 319795006302 putative Mg++ binding site [ion binding]; other site 319795006303 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 319795006304 ATP-binding site [chemical binding]; other site 319795006305 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 319795006306 iron binding site [ion binding]; other site 319795006307 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 319795006308 DEAD-like helicases superfamily; Region: DEXDc; smart00487 319795006309 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 319795006310 ATP binding site [chemical binding]; other site 319795006311 putative Mg++ binding site [ion binding]; other site 319795006312 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 319795006313 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 319795006314 nucleotide binding region [chemical binding]; other site 319795006315 ATP-binding site [chemical binding]; other site 319795006316 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 319795006317 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 319795006318 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 319795006319 active site 319795006320 substrate binding site [chemical binding]; other site 319795006321 cosubstrate binding site; other site 319795006322 catalytic site [active] 319795006323 hypothetical protein; Provisional; Region: PRK08201 319795006324 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 319795006325 metal binding site [ion binding]; metal-binding site 319795006326 putative dimer interface [polypeptide binding]; other site 319795006327 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 319795006328 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 319795006329 DNA binding residues [nucleotide binding] 319795006330 putative dimer interface [polypeptide binding]; other site 319795006331 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 319795006332 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 319795006333 DNA binding residues [nucleotide binding] 319795006334 putative dimer interface [polypeptide binding]; other site 319795006335 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 319795006336 active site 319795006337 metal binding site [ion binding]; metal-binding site 319795006338 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 319795006339 active site 319795006340 Late embryogenesis abundant protein; Region: LEA_2; cl12118 319795006341 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 319795006342 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 319795006343 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 319795006344 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 319795006345 NlpC/P60 family; Region: NLPC_P60; pfam00877 319795006346 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 319795006347 Fe-S cluster binding site [ion binding]; other site 319795006348 active site 319795006349 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 319795006350 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 319795006351 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 319795006352 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 319795006353 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 319795006354 phosphorylation site [posttranslational modification] 319795006355 dimer interface [polypeptide binding]; other site 319795006356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 319795006357 ATP binding site [chemical binding]; other site 319795006358 Mg2+ binding site [ion binding]; other site 319795006359 G-X-G motif; other site 319795006360 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 319795006361 Moco binding site; other site 319795006362 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 319795006363 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 319795006364 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 319795006365 tetramer interface [polypeptide binding]; other site 319795006366 TPP-binding site [chemical binding]; other site 319795006367 heterodimer interface [polypeptide binding]; other site 319795006368 phosphorylation loop region [posttranslational modification] 319795006369 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 319795006370 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 319795006371 alpha subunit interface [polypeptide binding]; other site 319795006372 TPP binding site [chemical binding]; other site 319795006373 heterodimer interface [polypeptide binding]; other site 319795006374 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 319795006375 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14855 319795006376 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 319795006377 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 319795006378 hypothetical protein; Provisional; Region: PRK14383 319795006379 RNase P protein component [Translation, ribosomal structure and biogenesis]; Region: RnpA; COG0594 319795006380 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 319795006381 antiporter inner membrane protein; Provisional; Region: PRK11670 319795006382 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 319795006383 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 319795006384 Predicted transcriptional regulator [Transcription]; Region: COG2345 319795006385 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 319795006386 putative DNA binding site [nucleotide binding]; other site 319795006387 putative Zn2+ binding site [ion binding]; other site 319795006388 Transcriptional regulator PadR-like family; Region: PadR; cl17335 319795006389 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 319795006390 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 319795006391 Chorismate mutase type II; Region: CM_2; cl00693 319795006392 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 319795006393 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 319795006394 apolar tunnel; other site 319795006395 heme binding site [chemical binding]; other site 319795006396 dimerization interface [polypeptide binding]; other site 319795006397 GTP-binding protein YchF; Reviewed; Region: PRK09601 319795006398 YchF GTPase; Region: YchF; cd01900 319795006399 G1 box; other site 319795006400 GTP/Mg2+ binding site [chemical binding]; other site 319795006401 Switch I region; other site 319795006402 G2 box; other site 319795006403 Switch II region; other site 319795006404 G3 box; other site 319795006405 G4 box; other site 319795006406 G5 box; other site 319795006407 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 319795006408 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 319795006409 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 319795006410 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 319795006411 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 319795006412 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 319795006413 RNA binding site [nucleotide binding]; other site 319795006414 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 319795006415 RNA binding site [nucleotide binding]; other site 319795006416 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 319795006417 RNA binding site [nucleotide binding]; other site 319795006418 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 319795006419 RNA binding site [nucleotide binding]; other site 319795006420 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 319795006421 RNA binding site [nucleotide binding]; other site 319795006422 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 319795006423 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 319795006424 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 319795006425 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 319795006426 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 319795006427 Competence protein; Region: Competence; pfam03772 319795006428 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 319795006429 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 319795006430 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 319795006431 EamA-like transporter family; Region: EamA; pfam00892 319795006432 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 319795006433 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 319795006434 S-adenosylmethionine binding site [chemical binding]; other site 319795006435 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 319795006436 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 319795006437 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 319795006438 TrkA-N domain; Region: TrkA_N; pfam02254 319795006439 TrkA-C domain; Region: TrkA_C; pfam02080 319795006440 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 319795006441 putative hydrolase; Provisional; Region: PRK02113 319795006442 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 319795006443 active site 319795006444 ribulose/triose binding site [chemical binding]; other site 319795006445 phosphate binding site [ion binding]; other site 319795006446 substrate (anthranilate) binding pocket [chemical binding]; other site 319795006447 product (indole) binding pocket [chemical binding]; other site 319795006448 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 319795006449 active site 319795006450 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 319795006451 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 319795006452 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 319795006453 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 319795006454 VanW like protein; Region: VanW; pfam04294 319795006455 HD supefamily hydrolase [General function prediction only]; Region: COG3294 319795006456 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 319795006457 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 319795006458 substrate binding site [chemical binding]; other site 319795006459 oxyanion hole (OAH) forming residues; other site 319795006460 trimer interface [polypeptide binding]; other site 319795006461 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 319795006462 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 319795006463 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 319795006464 S-layer homology domain; Region: SLH; pfam00395 319795006465 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 319795006466 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 319795006467 DHH family; Region: DHH; pfam01368 319795006468 DHHA1 domain; Region: DHHA1; pfam02272 319795006469 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 319795006470 dimer interface [polypeptide binding]; other site 319795006471 active site 319795006472 SurA N-terminal domain; Region: SurA_N_3; cl07813 319795006473 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 319795006474 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 319795006475 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 319795006476 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 319795006477 active site 319795006478 HIGH motif; other site 319795006479 dimer interface [polypeptide binding]; other site 319795006480 KMSKS motif; other site 319795006481 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 319795006482 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 319795006483 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 319795006484 ornithine carbamoyltransferase; Provisional; Region: PRK00779 319795006485 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 319795006486 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 319795006487 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 319795006488 EamA-like transporter family; Region: EamA; pfam00892 319795006489 ribonuclease Z; Provisional; Region: PRK02126 319795006490 histidinol-phosphatase; Provisional; Region: PRK07328 319795006491 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 319795006492 active site 319795006493 dimer interface [polypeptide binding]; other site 319795006494 hypothetical protein; Provisional; Region: PRK08609 319795006495 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 319795006496 metal binding triad [ion binding]; metal-binding site 319795006497 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 319795006498 active site 319795006499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 319795006500 Major Facilitator Superfamily; Region: MFS_1; pfam07690 319795006501 putative substrate translocation pore; other site 319795006502 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 319795006503 Phospholipid methyltransferase; Region: PEMT; cl17370 319795006504 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 319795006505 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 319795006506 Walker A; other site 319795006507 PAS fold; Region: PAS; pfam00989 319795006508 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 319795006509 putative active site [active] 319795006510 heme pocket [chemical binding]; other site 319795006511 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 319795006512 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 319795006513 metal binding site [ion binding]; metal-binding site 319795006514 active site 319795006515 I-site; other site 319795006516 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 319795006517 catalytic core [active] 319795006518 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 319795006519 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 319795006520 dimerization interface [polypeptide binding]; other site 319795006521 putative ATP binding site [chemical binding]; other site 319795006522 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 319795006523 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 319795006524 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 319795006525 substrate binding pocket [chemical binding]; other site 319795006526 chain length determination region; other site 319795006527 substrate-Mg2+ binding site; other site 319795006528 catalytic residues [active] 319795006529 aspartate-rich region 1; other site 319795006530 active site lid residues [active] 319795006531 aspartate-rich region 2; other site 319795006532 N-formylglutamate amidohydrolase; Region: FGase; cl01522 319795006533 recombination protein F; Provisional; Region: recF; PRK14079 319795006534 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 319795006535 Walker A/P-loop; other site 319795006536 ATP binding site [chemical binding]; other site 319795006537 Q-loop/lid; other site 319795006538 Protein of unknown function (DUF721); Region: DUF721; pfam05258 319795006539 Protein of unknown function (DUF721); Region: DUF721; cl02324 319795006540 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 319795006541 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 319795006542 S-adenosylmethionine binding site [chemical binding]; other site 319795006543 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 319795006544 RNA/DNA hybrid binding site [nucleotide binding]; other site 319795006545 active site 319795006546 GTP-binding protein LepA; Provisional; Region: PRK05433 319795006547 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 319795006548 G1 box; other site 319795006549 putative GEF interaction site [polypeptide binding]; other site 319795006550 GTP/Mg2+ binding site [chemical binding]; other site 319795006551 Switch I region; other site 319795006552 G2 box; other site 319795006553 G3 box; other site 319795006554 Switch II region; other site 319795006555 G4 box; other site 319795006556 G5 box; other site 319795006557 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 319795006558 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 319795006559 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 319795006560 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 319795006561 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 319795006562 dimer interface [polypeptide binding]; other site 319795006563 phosphorylation site [posttranslational modification] 319795006564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 319795006565 ATP binding site [chemical binding]; other site 319795006566 Mg2+ binding site [ion binding]; other site 319795006567 G-X-G motif; other site 319795006568 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 319795006569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 319795006570 active site 319795006571 phosphorylation site [posttranslational modification] 319795006572 intermolecular recognition site; other site 319795006573 dimerization interface [polypeptide binding]; other site 319795006574 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 319795006575 DNA binding residues [nucleotide binding] 319795006576 dimerization interface [polypeptide binding]; other site 319795006577 aspartate aminotransferase; Provisional; Region: PRK05764 319795006578 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 319795006579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 319795006580 homodimer interface [polypeptide binding]; other site 319795006581 catalytic residue [active] 319795006582 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 319795006583 putative FMN binding site [chemical binding]; other site 319795006584 Uncharacterized conserved protein [Function unknown]; Region: COG2013 319795006585 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 319795006586 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 319795006587 active site 319795006588 homodimer interface [polypeptide binding]; other site 319795006589 UDP-N-acetylmuramate--alanine ligase; Region: murC; TIGR01082 319795006590 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 319795006591 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 319795006592 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 319795006593 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14651 319795006594 FAD binding domain; Region: FAD_binding_4; pfam01565 319795006595 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 319795006596 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 319795006597 Cell division protein FtsQ; Region: FtsQ; pfam03799 319795006598 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 319795006599 Cell division protein FtsA; Region: FtsA; smart00842 319795006600 Cell division protein FtsA; Region: FtsA; pfam14450 319795006601 cell division protein FtsZ; Validated; Region: PRK09330 319795006602 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 319795006603 nucleotide binding site [chemical binding]; other site 319795006604 SulA interaction site; other site 319795006605 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 319795006606 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 319795006607 dimerization interface [polypeptide binding]; other site 319795006608 ligand binding site [chemical binding]; other site 319795006609 6-phosphofructokinase; Provisional; Region: PRK03202 319795006610 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 319795006611 active site 319795006612 ADP/pyrophosphate binding site [chemical binding]; other site 319795006613 dimerization interface [polypeptide binding]; other site 319795006614 allosteric effector site; other site 319795006615 fructose-1,6-bisphosphate binding site; other site 319795006616 Predicted methyltransferases [General function prediction only]; Region: COG0313 319795006617 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 319795006618 putative SAM binding site [chemical binding]; other site 319795006619 putative homodimer interface [polypeptide binding]; other site 319795006620 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 319795006621 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 319795006622 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 319795006623 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 319795006624 Peptidase M16C associated; Region: M16C_assoc; pfam08367 319795006625 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 319795006626 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 319795006627 RNA binding surface [nucleotide binding]; other site 319795006628 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 319795006629 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 319795006630 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 319795006631 Catalytic site [active] 319795006632 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 319795006633 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 319795006634 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 319795006635 active site 319795006636 tetramer interface [polypeptide binding]; other site 319795006637 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 319795006638 MPN+ (JAMM) motif; other site 319795006639 Zinc-binding site [ion binding]; other site 319795006640 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 319795006641 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 319795006642 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 319795006643 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 319795006644 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 319795006645 Fasciclin domain; Region: Fasciclin; pfam02469 319795006646 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 319795006647 Fasciclin domain; Region: Fasciclin; pfam02469 319795006648 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 319795006649 Fasciclin domain; Region: Fasciclin; pfam02469 319795006650 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 319795006651 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 319795006652 active site 319795006653 metal binding site [ion binding]; metal-binding site 319795006654 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 319795006655 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 319795006656 dimer interface [polypeptide binding]; other site 319795006657 pyridoxal 5'-phosphate binding site [chemical binding]; other site 319795006658 catalytic residue [active] 319795006659 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 319795006660 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 319795006661 Putative catalytic NodB homology domain of uncharacterized prokaryotic polysaccharide deacetylases which consist of a 6-stranded beta/alpha barrel; Region: CE4_DAC_u1_6s; cd10970 319795006662 putative active site [active] 319795006663 putative metal binding site [ion binding]; other site 319795006664 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 319795006665 active site 319795006666 DNA binding site [nucleotide binding] 319795006667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 319795006668 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 319795006669 Protein of unknown function (DUF1679); Region: DUF1679; pfam07914 319795006670 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14323 319795006671 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 319795006672 active site 319795006673 substrate binding site [chemical binding]; other site 319795006674 metal binding site [ion binding]; metal-binding site 319795006675 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 319795006676 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 319795006677 Leishmanolysin; Region: Peptidase_M8; pfam01457 319795006678 5'-3' exonuclease; Region: 53EXOc; smart00475 319795006679 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 319795006680 active site 319795006681 metal binding site 1 [ion binding]; metal-binding site 319795006682 putative 5' ssDNA interaction site; other site 319795006683 metal binding site 3; metal-binding site 319795006684 metal binding site 2 [ion binding]; metal-binding site 319795006685 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 319795006686 putative DNA binding site [nucleotide binding]; other site 319795006687 putative metal binding site [ion binding]; other site 319795006688 Taq polymerase, exonuclease; Region: Taq-exonuc; pfam09281 319795006689 DNA polymerase I; Provisional; Region: PRK05755 319795006690 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 319795006691 active site 319795006692 DNA binding site [nucleotide binding] 319795006693 catalytic site [active] 319795006694 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 319795006695 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 319795006696 FOG: WD40 repeat [General function prediction only]; Region: COG2319 319795006697 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 319795006698 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 319795006699 Protein of unknown function (DUF970); Region: DUF970; pfam06153 319795006700 PAS fold; Region: PAS_4; pfam08448 319795006701 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 319795006702 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 319795006703 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 319795006704 metal binding site [ion binding]; metal-binding site 319795006705 active site 319795006706 I-site; other site 319795006707 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 319795006708 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 319795006709 Walker A/P-loop; other site 319795006710 ATP binding site [chemical binding]; other site 319795006711 Q-loop/lid; other site 319795006712 ABC transporter signature motif; other site 319795006713 Walker B; other site 319795006714 D-loop; other site 319795006715 H-loop/switch region; other site 319795006716 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 319795006717 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 319795006718 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 319795006719 PRC-barrel domain; Region: PRC; pfam05239 319795006720 PRC-barrel domain; Region: PRC; pfam05239 319795006721 AAA domain; Region: AAA_18; pfam13238 319795006722 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 319795006723 Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and residues that can...; Region: MLE_like; cd03315 319795006724 active site 319795006725 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 319795006726 active site 319795006727 catalytic residues [active] 319795006728 aconitate hydratase; Validated; Region: PRK09277 319795006729 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 319795006730 substrate binding site [chemical binding]; other site 319795006731 ligand binding site [chemical binding]; other site 319795006732 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 319795006733 substrate binding site [chemical binding]; other site 319795006734 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 319795006735 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 319795006736 malonyl-CoA binding site [chemical binding]; other site 319795006737 dimer interface [polypeptide binding]; other site 319795006738 active site 319795006739 product binding site; other site 319795006740 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 319795006741 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 319795006742 active site 319795006743 catalytic tetrad [active] 319795006744 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 319795006745 FMN binding site [chemical binding]; other site 319795006746 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 319795006747 dimer interface [polypeptide binding]; other site 319795006748 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 319795006749 active site 319795006750 multimer interface [polypeptide binding]; other site 319795006751 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 319795006752 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 319795006753 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 319795006754 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 319795006755 TM-ABC transporter signature motif; other site 319795006756 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 319795006757 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 319795006758 TM-ABC transporter signature motif; other site 319795006759 Transcriptional regulator [Transcription]; Region: LysR; COG0583 319795006760 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 319795006761 dimerization interface [polypeptide binding]; other site 319795006762 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 319795006763 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 319795006764 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 319795006765 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 319795006766 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 319795006767 Ribosome-binding factor A [Translation, ribosomal structure and biogenesis]; Region: RbfA; COG0858 319795006768 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 319795006769 active site 319795006770 NUDIX domain; Region: NUDIX; pfam00293 319795006771 nudix motif; other site 319795006772 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 319795006773 Zn binding site [ion binding]; other site 319795006774 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 319795006775 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795006776 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 319795006777 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 319795006778 DDE superfamily endonuclease; Region: DDE_5; cl17874 319795006779 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795006780 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 319795006781 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 319795006782 active site 319795006783 DNA binding site [nucleotide binding] 319795006784 Int/Topo IB signature motif; other site 319795006785 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 319795006786 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 319795006787 Putative sensor; Region: Sensor; pfam13796 319795006788 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 319795006789 Histidine kinase; Region: HisKA_3; pfam07730 319795006790 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 319795006791 ATP binding site [chemical binding]; other site 319795006792 Mg2+ binding site [ion binding]; other site 319795006793 G-X-G motif; other site 319795006794 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 319795006795 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 319795006796 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 319795006797 active site 319795006798 phosphorylation site [posttranslational modification] 319795006799 intermolecular recognition site; other site 319795006800 dimerization interface [polypeptide binding]; other site 319795006801 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 319795006802 DNA binding residues [nucleotide binding] 319795006803 dimerization interface [polypeptide binding]; other site 319795006804 Cupin domain; Region: Cupin_2; pfam07883 319795006805 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 319795006806 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 319795006807 active site 319795006808 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 319795006809 catalytic tetrad [active] 319795006810 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 319795006811 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 319795006812 active site 319795006813 metal binding site [ion binding]; metal-binding site 319795006814 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 319795006815 Domain of unknown function DUF20; Region: UPF0118; pfam01594 319795006816 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 319795006817 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 319795006818 active site 319795006819 HIGH motif; other site 319795006820 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 319795006821 KMSKS motif; other site 319795006822 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 319795006823 tRNA binding surface [nucleotide binding]; other site 319795006824 anticodon binding site; other site 319795006825 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 319795006826 glycyl-tRNA synthetase; Provisional; Region: PRK04173 319795006827 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 319795006828 motif 1; other site 319795006829 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 319795006830 active site 319795006831 motif 2; other site 319795006832 motif 3; other site 319795006833 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 319795006834 anticodon binding site; other site 319795006835 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 319795006836 active site 319795006837 SUMO-1 interface [polypeptide binding]; other site 319795006838 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 319795006839 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 319795006840 Moco binding site; other site 319795006841 metal coordination site [ion binding]; other site 319795006842 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 319795006843 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 319795006844 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 319795006845 DAK2 domain; Region: Dak2; pfam02734 319795006846 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 319795006847 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 319795006848 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 319795006849 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 319795006850 Cell division protein FtsA; Region: FtsA; pfam14450 319795006851 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 319795006852 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 319795006853 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 319795006854 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 319795006855 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 319795006856 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 319795006857 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 319795006858 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 319795006859 Tetramer interface [polypeptide binding]; other site 319795006860 active site 319795006861 FMN-binding site [chemical binding]; other site 319795006862 shikimate kinase; Provisional; Region: PRK13948 319795006863 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 319795006864 ADP binding site [chemical binding]; other site 319795006865 magnesium binding site [ion binding]; other site 319795006866 putative shikimate binding site; other site 319795006867 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 319795006868 active site 319795006869 dimer interface [polypeptide binding]; other site 319795006870 metal binding site [ion binding]; metal-binding site 319795006871 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 319795006872 Dehydroquinase class II; Region: DHquinase_II; pfam01220 319795006873 active site 319795006874 trimer interface [polypeptide binding]; other site 319795006875 dimer interface [polypeptide binding]; other site 319795006876 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 319795006877 23S rRNA interface [nucleotide binding]; other site 319795006878 L3 interface [polypeptide binding]; other site 319795006879 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 319795006880 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 319795006881 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 319795006882 Walker A/P-loop; other site 319795006883 ATP binding site [chemical binding]; other site 319795006884 Q-loop/lid; other site 319795006885 ABC transporter signature motif; other site 319795006886 Walker B; other site 319795006887 D-loop; other site 319795006888 H-loop/switch region; other site 319795006889 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 319795006890 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 319795006891 Walker A/P-loop; other site 319795006892 ATP binding site [chemical binding]; other site 319795006893 ABC transporter signature motif; other site 319795006894 Walker B; other site 319795006895 D-loop; other site 319795006896 H-loop/switch region; other site 319795006897 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 319795006898 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 319795006899 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 319795006900 Predicted acetyltransferase [General function prediction only]; Region: COG3981 319795006901 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 319795006902 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 319795006903 lipoyl synthase; Provisional; Region: PRK05481 319795006904 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 319795006905 FeS/SAM binding site; other site 319795006906 short chain dehydrogenase; Provisional; Region: PRK08309 319795006907 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 319795006908 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 319795006909 metal binding site [ion binding]; metal-binding site 319795006910 active site 319795006911 I-site; other site 319795006912 Domain of unknown function (DUF427); Region: DUF427; pfam04248 319795006913 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 319795006914 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 319795006915 active site 319795006916 catalytic site [active] 319795006917 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 319795006918 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 319795006919 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 319795006920 pantothenate kinase; Reviewed; Region: PRK13318 319795006921 acetyl-CoA synthetase; Provisional; Region: PRK00174 319795006922 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 319795006923 acyl-activating enzyme (AAE) consensus motif; other site 319795006924 AMP binding site [chemical binding]; other site 319795006925 active site 319795006926 CoA binding site [chemical binding]; other site 319795006927 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 319795006928 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 319795006929 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 319795006930 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 319795006931 active site 319795006932 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 319795006933 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 319795006934 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 319795006935 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 319795006936 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 319795006937 NodB motif; other site 319795006938 putative active site [active] 319795006939 putative catalytic site [active] 319795006940 putative Zn binding site [ion binding]; other site 319795006941 succinyldiaminopimelate transaminase; Validated; Region: PRK07366 319795006942 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 319795006943 pyridoxal 5'-phosphate binding site [chemical binding]; other site 319795006944 homodimer interface [polypeptide binding]; other site 319795006945 catalytic residue [active] 319795006946 acetyl-CoA synthetase; Provisional; Region: PRK00174 319795006947 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 319795006948 active site 319795006949 CoA binding site [chemical binding]; other site 319795006950 acyl-activating enzyme (AAE) consensus motif; other site 319795006951 AMP binding site [chemical binding]; other site 319795006952 acetate binding site [chemical binding]; other site 319795006953 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 319795006954 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 319795006955 Na binding site [ion binding]; other site 319795006956 Protein of unknown function, DUF485; Region: DUF485; cl01231 319795006957 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 319795006958 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 319795006959 FeS/SAM binding site; other site 319795006960 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 319795006961 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 319795006962 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 319795006963 DNA-binding site [nucleotide binding]; DNA binding site 319795006964 UTRA domain; Region: UTRA; pfam07702 319795006965 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 319795006966 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 319795006967 2-phosphoglycerate kinase; Provisional; Region: PRK12337 319795006968 ATP cone domain; Region: ATP-cone; pfam03477 319795006969 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 319795006970 Stage II sporulation protein; Region: SpoIID; pfam08486 319795006971 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 319795006972 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 319795006973 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 319795006974 Beta-lactamase; Region: Beta-lactamase; pfam00144 319795006975 arginine decarboxylase; Provisional; Region: PRK05354 319795006976 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 319795006977 dimer interface [polypeptide binding]; other site 319795006978 active site 319795006979 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 319795006980 catalytic residues [active] 319795006981 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 319795006982 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 319795006983 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 319795006984 ribonucleoside-diphosphate reductase, class 1b, alpha subunit; Region: RNR_1b_NrdE; TIGR04170 319795006985 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 319795006986 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 319795006987 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 319795006988 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 319795006989 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 319795006990 dimer interface [polypeptide binding]; other site 319795006991 putative radical transfer pathway; other site 319795006992 diiron center [ion binding]; other site 319795006993 tyrosyl radical; other site 319795006994 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 319795006995 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 319795006996 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 319795006997 S-adenosylmethionine binding site [chemical binding]; other site 319795006998 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 319795006999 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 319795007000 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 319795007001 Rhomboid family; Region: Rhomboid; cl11446 319795007002 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 319795007003 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 319795007004 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795007005 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 319795007006 membrane protein; Provisional; Region: PRK14402 319795007007 GAF domain; Region: GAF; pfam01590 319795007008 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 319795007009 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 319795007010 active site 319795007011 I-site; other site 319795007012 metal binding site [ion binding]; metal-binding site 319795007013 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 319795007014 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 319795007015 dimer interface [polypeptide binding]; other site 319795007016 substrate binding site [chemical binding]; other site 319795007017 metal binding site [ion binding]; metal-binding site 319795007018 Predicted integral membrane protein [Function unknown]; Region: COG5652 319795007019 MoxR-like ATPases [General function prediction only]; Region: COG0714 319795007020 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 319795007021 Walker A motif; other site 319795007022 ATP binding site [chemical binding]; other site 319795007023 Walker B motif; other site 319795007024 arginine finger; other site 319795007025 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 319795007026 Protein of unknown function DUF58; Region: DUF58; pfam01882 319795007027 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 319795007028 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 319795007029 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 319795007030 threonine dehydratase; Reviewed; Region: PRK09224 319795007031 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 319795007032 tetramer interface [polypeptide binding]; other site 319795007033 pyridoxal 5'-phosphate binding site [chemical binding]; other site 319795007034 catalytic residue [active] 319795007035 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 319795007036 putative Ile/Val binding site [chemical binding]; other site 319795007037 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 319795007038 putative Ile/Val binding site [chemical binding]; other site 319795007039 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 319795007040 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 319795007041 Peptidase family M23; Region: Peptidase_M23; pfam01551 319795007042 enoyl-CoA hydratase; Provisional; Region: PRK08140 319795007043 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 319795007044 substrate binding site [chemical binding]; other site 319795007045 oxyanion hole (OAH) forming residues; other site 319795007046 trimer interface [polypeptide binding]; other site 319795007047 YtxH-like protein; Region: YtxH; cl02079 319795007048 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 319795007049 Asn-Pro-Ala signature motifs; other site 319795007050 Predicted amidohydrolase [General function prediction only]; Region: COG0388 319795007051 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 319795007052 active site 319795007053 catalytic triad [active] 319795007054 dimer interface [polypeptide binding]; other site 319795007055 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 319795007056 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 319795007057 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 319795007058 uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_1; cd10801 319795007059 putative active site [active] 319795007060 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 319795007061 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 319795007062 Zn2+ binding site [ion binding]; other site 319795007063 Mg2+ binding site [ion binding]; other site 319795007064 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 319795007065 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 319795007066 ABC-2 type transporter; Region: ABC2_membrane; cl17235 319795007067 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 319795007068 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 319795007069 Walker A/P-loop; other site 319795007070 ATP binding site [chemical binding]; other site 319795007071 Q-loop/lid; other site 319795007072 ABC transporter signature motif; other site 319795007073 Walker B; other site 319795007074 D-loop; other site 319795007075 H-loop/switch region; other site 319795007076 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795007077 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 319795007078 dimer interface [polypeptide binding]; other site 319795007079 ADP-ribose binding site [chemical binding]; other site 319795007080 active site 319795007081 nudix motif; other site 319795007082 metal binding site [ion binding]; metal-binding site 319795007083 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 319795007084 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 319795007085 active site 319795007086 Riboflavin kinase; Region: Flavokinase; pfam01687 319795007087 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 319795007088 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 319795007089 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 319795007090 Walker A/P-loop; other site 319795007091 ATP binding site [chemical binding]; other site 319795007092 Q-loop/lid; other site 319795007093 ABC transporter signature motif; other site 319795007094 Walker B; other site 319795007095 D-loop; other site 319795007096 H-loop/switch region; other site 319795007097 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 319795007098 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 319795007099 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 319795007100 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 319795007101 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 319795007102 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 319795007103 G1 box; other site 319795007104 GTP/Mg2+ binding site [chemical binding]; other site 319795007105 G2 box; other site 319795007106 Switch I region; other site 319795007107 G3 box; other site 319795007108 Switch II region; other site 319795007109 G4 box; other site 319795007110 G5 box; other site 319795007111 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 319795007112 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 319795007113 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 319795007114 active site 319795007115 catalytic site [active] 319795007116 substrate binding site [chemical binding]; other site 319795007117 UV-endonuclease UvdE; Region: UvdE; cl10036 319795007118 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 319795007119 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 319795007120 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 319795007121 Yip1 domain; Region: Yip1; cl17815 319795007122 GTPase Era; Reviewed; Region: era; PRK00089 319795007123 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 319795007124 G1 box; other site 319795007125 GTP/Mg2+ binding site [chemical binding]; other site 319795007126 Switch I region; other site 319795007127 G2 box; other site 319795007128 Switch II region; other site 319795007129 G3 box; other site 319795007130 G4 box; other site 319795007131 G5 box; other site 319795007132 KH domain; Region: KH_2; pfam07650 319795007133 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 319795007134 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 319795007135 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 319795007136 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 319795007137 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 319795007138 nudix motif; other site 319795007139 metal-dependent hydrolase; Provisional; Region: PRK13291 319795007140 DinB superfamily; Region: DinB_2; pfam12867 319795007141 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 319795007142 homodimer interface [polypeptide binding]; other site 319795007143 metal binding site [ion binding]; metal-binding site 319795007144 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 319795007145 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 319795007146 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 319795007147 Walker A motif; other site 319795007148 ATP binding site [chemical binding]; other site 319795007149 Walker B motif; other site 319795007150 arginine finger; other site 319795007151 Peptidase family M41; Region: Peptidase_M41; pfam01434 319795007152 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 319795007153 Mechanosensitive ion channel; Region: MS_channel; pfam00924 319795007154 putative phosphate acyltransferase; Provisional; Region: PRK05331 319795007155 Uncharacterized conserved protein [Function unknown]; Region: COG1432 319795007156 LabA_like proteins; Region: LabA; cd10911 319795007157 putative metal binding site [ion binding]; other site 319795007158 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 319795007159 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 319795007160 catalytic residues [active] 319795007161 Serine hydrolase; Region: Ser_hydrolase; pfam06821 319795007162 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 319795007163 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 319795007164 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 319795007165 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 319795007166 alphaNTD - beta interaction site [polypeptide binding]; other site 319795007167 alphaNTD homodimer interface [polypeptide binding]; other site 319795007168 alphaNTD - beta' interaction site [polypeptide binding]; other site 319795007169 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 319795007170 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 319795007171 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 319795007172 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 319795007173 RNA binding surface [nucleotide binding]; other site 319795007174 30S ribosomal protein S11; Validated; Region: PRK05309 319795007175 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 319795007176 30S ribosomal protein S13; Region: bact_S13; TIGR03631 319795007177 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 319795007178 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 319795007179 rRNA binding site [nucleotide binding]; other site 319795007180 predicted 30S ribosome binding site; other site 319795007181 adenylate kinase; Provisional; Region: PRK14527 319795007182 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 319795007183 AMP-binding site [chemical binding]; other site 319795007184 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 319795007185 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 319795007186 SecY translocase; Region: SecY; pfam00344 319795007187 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 319795007188 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 319795007189 23S rRNA binding site [nucleotide binding]; other site 319795007190 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 319795007191 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 319795007192 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 319795007193 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 319795007194 5S rRNA interface [nucleotide binding]; other site 319795007195 23S rRNA interface [nucleotide binding]; other site 319795007196 L5 interface [polypeptide binding]; other site 319795007197 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 319795007198 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 319795007199 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 319795007200 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 319795007201 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 319795007202 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 319795007203 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 319795007204 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 319795007205 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 319795007206 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 319795007207 RNA binding site [nucleotide binding]; other site 319795007208 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 319795007209 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 319795007210 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 319795007211 23S rRNA interface [nucleotide binding]; other site 319795007212 putative translocon interaction site; other site 319795007213 signal recognition particle (SRP54) interaction site; other site 319795007214 L23 interface [polypeptide binding]; other site 319795007215 trigger factor interaction site; other site 319795007216 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 319795007217 23S rRNA interface [nucleotide binding]; other site 319795007218 5S rRNA interface [nucleotide binding]; other site 319795007219 putative antibiotic binding site [chemical binding]; other site 319795007220 L25 interface [polypeptide binding]; other site 319795007221 L27 interface [polypeptide binding]; other site 319795007222 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 319795007223 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 319795007224 G-X-X-G motif; other site 319795007225 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 319795007226 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 319795007227 putative translocon binding site; other site 319795007228 protein-rRNA interface [nucleotide binding]; other site 319795007229 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 319795007230 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 319795007231 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 319795007232 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 319795007233 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 319795007234 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 319795007235 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 319795007236 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 319795007237 elongation factor Tu; Reviewed; Region: PRK00049 319795007238 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 319795007239 G1 box; other site 319795007240 GEF interaction site [polypeptide binding]; other site 319795007241 GTP/Mg2+ binding site [chemical binding]; other site 319795007242 Switch I region; other site 319795007243 G2 box; other site 319795007244 G3 box; other site 319795007245 Switch II region; other site 319795007246 G4 box; other site 319795007247 G5 box; other site 319795007248 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 319795007249 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 319795007250 Antibiotic Binding Site [chemical binding]; other site 319795007251 elongation factor G; Reviewed; Region: PRK00007 319795007252 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 319795007253 G1 box; other site 319795007254 putative GEF interaction site [polypeptide binding]; other site 319795007255 GTP/Mg2+ binding site [chemical binding]; other site 319795007256 Switch I region; other site 319795007257 G2 box; other site 319795007258 G3 box; other site 319795007259 Switch II region; other site 319795007260 G4 box; other site 319795007261 G5 box; other site 319795007262 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 319795007263 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 319795007264 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 319795007265 30S ribosomal protein S7; Validated; Region: PRK05302 319795007266 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 319795007267 S17 interaction site [polypeptide binding]; other site 319795007268 S8 interaction site; other site 319795007269 16S rRNA interaction site [nucleotide binding]; other site 319795007270 streptomycin interaction site [chemical binding]; other site 319795007271 23S rRNA interaction site [nucleotide binding]; other site 319795007272 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 319795007273 phosphoglucomutase; Validated; Region: PRK07564 319795007274 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 319795007275 active site 319795007276 substrate binding site [chemical binding]; other site 319795007277 metal binding site [ion binding]; metal-binding site 319795007278 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 319795007279 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 319795007280 putative active site [active] 319795007281 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 319795007282 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 319795007283 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 319795007284 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 319795007285 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 319795007286 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 319795007287 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 319795007288 active site 319795007289 metal binding site [ion binding]; metal-binding site 319795007290 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 319795007291 trimer interface [polypeptide binding]; other site 319795007292 active site 319795007293 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 319795007294 active site 319795007295 putative acyltransferase; Provisional; Region: PRK05790 319795007296 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 319795007297 dimer interface [polypeptide binding]; other site 319795007298 active site 319795007299 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 319795007300 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 319795007301 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 319795007302 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 319795007303 Gammaherpesvirus latent membrane protein (LMP2) protein; Region: Herpes_LMP2; pfam07415 319795007304 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 319795007305 E3 interaction surface; other site 319795007306 lipoyl attachment site [posttranslational modification]; other site 319795007307 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 319795007308 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 319795007309 E3 interaction surface; other site 319795007310 lipoyl attachment site [posttranslational modification]; other site 319795007311 e3 binding domain; Region: E3_binding; pfam02817 319795007312 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 319795007313 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 319795007314 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 319795007315 dimer interface [polypeptide binding]; other site 319795007316 TPP-binding site [chemical binding]; other site 319795007317 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 319795007318 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 319795007319 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 319795007320 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 319795007321 dimerization interface [polypeptide binding]; other site 319795007322 substrate binding pocket [chemical binding]; other site 319795007323 AAA domain; Region: AAA_17; pfam13207 319795007324 AAA domain; Region: AAA_33; pfam13671 319795007325 excinuclease ABC subunit B; Provisional; Region: PRK05298 319795007326 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 319795007327 ATP binding site [chemical binding]; other site 319795007328 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 319795007329 nucleotide binding region [chemical binding]; other site 319795007330 ATP-binding site [chemical binding]; other site 319795007331 Ultra-violet resistance protein B; Region: UvrB; pfam12344 319795007332 UvrB/uvrC motif; Region: UVR; pfam02151 319795007333 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 319795007334 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 319795007335 dsRNA binding site [nucleotide binding]; other site 319795007336 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 319795007337 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 319795007338 motif II; other site 319795007339 hypothetical protein; Reviewed; Region: PRK12497 319795007340 Transglycosylase; Region: Transgly; pfam00912 319795007341 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 319795007342 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 319795007343 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 319795007344 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 319795007345 Ligand Binding Site [chemical binding]; other site 319795007346 TIGR00269 family protein; Region: TIGR00269 319795007347 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 319795007348 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 319795007349 Uncharacterized conserved protein [Function unknown]; Region: COG1801 319795007350 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 319795007351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 319795007352 active site 319795007353 phosphorylation site [posttranslational modification] 319795007354 intermolecular recognition site; other site 319795007355 dimerization interface [polypeptide binding]; other site 319795007356 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 319795007357 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 319795007358 substrate binding site [chemical binding]; other site 319795007359 glutamase interaction surface [polypeptide binding]; other site 319795007360 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 319795007361 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 319795007362 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 319795007363 metal binding site [ion binding]; metal-binding site 319795007364 Tthb094 and related proteins, classical (c) SDRs; Region: Tthb094_like_SDR_c; cd11730 319795007365 NAD(P) binding site [chemical binding]; other site 319795007366 putative active site [active] 319795007367 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 319795007368 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 319795007369 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 319795007370 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 319795007371 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 319795007372 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 319795007373 lipoyl attachment site [posttranslational modification]; other site 319795007374 glycine dehydrogenase; Provisional; Region: PRK05367 319795007375 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 319795007376 tetramer interface [polypeptide binding]; other site 319795007377 pyridoxal 5'-phosphate binding site [chemical binding]; other site 319795007378 catalytic residue [active] 319795007379 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 319795007380 tetramer interface [polypeptide binding]; other site 319795007381 pyridoxal 5'-phosphate binding site [chemical binding]; other site 319795007382 catalytic residue [active] 319795007383 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 319795007384 non-specific DNA binding site [nucleotide binding]; other site 319795007385 salt bridge; other site 319795007386 sequence-specific DNA binding site [nucleotide binding]; other site 319795007387 Domain of unknown function (DUF955); Region: DUF955; cl01076 319795007388 DNA primase; Validated; Region: dnaG; PRK05667 319795007389 CHC2 zinc finger; Region: zf-CHC2; pfam01807 319795007390 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 319795007391 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 319795007392 active site 319795007393 metal binding site [ion binding]; metal-binding site 319795007394 interdomain interaction site; other site 319795007395 Predicted periplasmic protein [Function unknown]; Region: COG3698 319795007396 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 319795007397 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 319795007398 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 319795007399 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 319795007400 substrate binding site [chemical binding]; other site 319795007401 dimer interface [polypeptide binding]; other site 319795007402 NADP binding site [chemical binding]; other site 319795007403 catalytic residues [active] 319795007404 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 319795007405 substrate binding site [chemical binding]; other site 319795007406 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 319795007407 active site 319795007408 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 319795007409 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 319795007410 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 319795007411 Phenylacetic acid degradation B; Region: PaaB; cl01371 319795007412 Phenylacetic acid degradation B; Region: PaaB; cl01371 319795007413 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 319795007414 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 319795007415 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 319795007416 dimer interface [polypeptide binding]; other site 319795007417 substrate binding site [chemical binding]; other site 319795007418 ATP binding site [chemical binding]; other site 319795007419 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 319795007420 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 319795007421 ThiS interaction site; other site 319795007422 putative active site [active] 319795007423 tetramer interface [polypeptide binding]; other site 319795007424 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 319795007425 thiS-thiF/thiG interaction site; other site 319795007426 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 319795007427 thiamine phosphate binding site [chemical binding]; other site 319795007428 active site 319795007429 pyrophosphate binding site [ion binding]; other site 319795007430 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 319795007431 ThiC-associated domain; Region: ThiC-associated; pfam13667 319795007432 ThiC family; Region: ThiC; pfam01964 319795007433 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 319795007434 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 319795007435 active site 319795007436 catalytic tetrad [active] 319795007437 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 319795007438 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK14662 319795007439 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 319795007440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 319795007441 putative substrate translocation pore; other site 319795007442 Transcriptional regulators [Transcription]; Region: MarR; COG1846 319795007443 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 319795007444 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 319795007445 nudix motif; other site 319795007446 cyanate transporter; Region: CynX; TIGR00896 319795007447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 319795007448 putative substrate translocation pore; other site 319795007449 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 319795007450 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 319795007451 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 319795007452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795007453 dimer interface [polypeptide binding]; other site 319795007454 conserved gate region; other site 319795007455 putative PBP binding loops; other site 319795007456 ABC-ATPase subunit interface; other site 319795007457 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 319795007458 PemK-like protein; Region: PemK; cl00995 319795007459 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 319795007460 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 319795007461 Walker A/P-loop; other site 319795007462 ATP binding site [chemical binding]; other site 319795007463 Q-loop/lid; other site 319795007464 ABC transporter signature motif; other site 319795007465 Walker B; other site 319795007466 D-loop; other site 319795007467 H-loop/switch region; other site 319795007468 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 319795007469 Thiamine pyrophosphokinase; Region: TPK; cd07995 319795007470 active site 319795007471 dimerization interface [polypeptide binding]; other site 319795007472 thiamine binding site [chemical binding]; other site 319795007473 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 319795007474 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 319795007475 inhibitor-cofactor binding pocket; inhibition site 319795007476 pyridoxal 5'-phosphate binding site [chemical binding]; other site 319795007477 catalytic residue [active] 319795007478 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 319795007479 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 319795007480 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 319795007481 dimer interface [polypeptide binding]; other site 319795007482 putative functional site; other site 319795007483 putative MPT binding site; other site 319795007484 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 319795007485 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 319795007486 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 319795007487 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 319795007488 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 319795007489 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 319795007490 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 319795007491 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 319795007492 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 319795007493 catalytic loop [active] 319795007494 iron binding site [ion binding]; other site 319795007495 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 319795007496 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 319795007497 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 319795007498 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 319795007499 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 319795007500 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 319795007501 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 319795007502 HIGH motif; other site 319795007503 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 319795007504 active site 319795007505 KMSKS motif; other site 319795007506 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 319795007507 tRNA binding surface [nucleotide binding]; other site 319795007508 anticodon binding site; other site 319795007509 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 319795007510 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 319795007511 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 319795007512 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 319795007513 catalytic residue [active] 319795007514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 319795007515 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 319795007516 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 319795007517 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 319795007518 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 319795007519 AzlC protein; Region: AzlC; cl00570 319795007520 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 319795007521 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 319795007522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795007523 dimer interface [polypeptide binding]; other site 319795007524 conserved gate region; other site 319795007525 putative PBP binding loops; other site 319795007526 ABC-ATPase subunit interface; other site 319795007527 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 319795007528 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 319795007529 substrate binding pocket [chemical binding]; other site 319795007530 membrane-bound complex binding site; other site 319795007531 hinge residues; other site 319795007532 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 319795007533 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 319795007534 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 319795007535 putative NAD(P) binding site [chemical binding]; other site 319795007536 putative active site [active] 319795007537 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 319795007538 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 319795007539 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 319795007540 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14358 319795007541 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 319795007542 Substrate binding site; other site 319795007543 Mg++ binding site; other site 319795007544 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 319795007545 active site 319795007546 substrate binding site [chemical binding]; other site 319795007547 CoA binding site [chemical binding]; other site 319795007548 H+ Antiporter protein; Region: 2A0121; TIGR00900 319795007549 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 319795007550 RNA/DNA hybrid binding site [nucleotide binding]; other site 319795007551 active site 319795007552 Tic20-like protein; Region: Tic20; pfam09685 319795007553 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 319795007554 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 319795007555 hydrophobic ligand binding site; other site 319795007556 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 319795007557 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 319795007558 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 319795007559 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 319795007560 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 319795007561 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 319795007562 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 319795007563 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 319795007564 putative active site [active] 319795007565 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 319795007566 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 319795007567 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 319795007568 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 319795007569 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 319795007570 epoxyqueuosine reductase; Region: TIGR00276 319795007571 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 319795007572 4Fe-4S binding domain; Region: Fer4_6; pfam12837 319795007573 HEAT repeat; Region: HEAT; pfam02985 319795007574 SnoaL-like domain; Region: SnoaL_2; pfam12680 319795007575 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 319795007576 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 319795007577 dimer interface [polypeptide binding]; other site 319795007578 putative metal binding site [ion binding]; other site 319795007579 Uncharacterized conserved protein [Function unknown]; Region: COG0327 319795007580 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 319795007581 thymidylate kinase; Validated; Region: tmk; PRK00698 319795007582 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 319795007583 TMP-binding site; other site 319795007584 ATP-binding site [chemical binding]; other site 319795007585 Predicted transcriptional regulators [Transcription]; Region: COG1378 319795007586 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 319795007587 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 319795007588 putative active site [active] 319795007589 catalytic site [active] 319795007590 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 319795007591 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 319795007592 substrate binding pocket [chemical binding]; other site 319795007593 membrane-bound complex binding site; other site 319795007594 hinge residues; other site 319795007595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795007596 dimer interface [polypeptide binding]; other site 319795007597 conserved gate region; other site 319795007598 putative PBP binding loops; other site 319795007599 ABC-ATPase subunit interface; other site 319795007600 glycogen synthase; Provisional; Region: glgA; PRK00654 319795007601 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 319795007602 ADP-binding pocket [chemical binding]; other site 319795007603 homodimer interface [polypeptide binding]; other site 319795007604 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 319795007605 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 319795007606 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 319795007607 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 319795007608 GAF domain; Region: GAF_3; pfam13492 319795007609 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 319795007610 Histidine kinase; Region: HisKA_3; pfam07730 319795007611 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 319795007612 ATP binding site [chemical binding]; other site 319795007613 Mg2+ binding site [ion binding]; other site 319795007614 G-X-G motif; other site 319795007615 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 319795007616 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 319795007617 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 319795007618 oligomer interface [polypeptide binding]; other site 319795007619 active site 319795007620 metal binding site [ion binding]; metal-binding site 319795007621 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 319795007622 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 319795007623 FMN binding site [chemical binding]; other site 319795007624 active site 319795007625 catalytic residues [active] 319795007626 substrate binding site [chemical binding]; other site 319795007627 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 319795007628 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 319795007629 FeS/SAM binding site; other site 319795007630 PAS fold; Region: PAS_3; pfam08447 319795007631 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 319795007632 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 319795007633 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 319795007634 Zn2+ binding site [ion binding]; other site 319795007635 Mg2+ binding site [ion binding]; other site 319795007636 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 319795007637 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 319795007638 active site 319795007639 interdomain interaction site; other site 319795007640 putative metal-binding site [ion binding]; other site 319795007641 nucleotide binding site [chemical binding]; other site 319795007642 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 319795007643 domain I; other site 319795007644 phosphate binding site [ion binding]; other site 319795007645 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 319795007646 domain II; other site 319795007647 domain III; other site 319795007648 nucleotide binding site [chemical binding]; other site 319795007649 DNA binding groove [nucleotide binding] 319795007650 catalytic site [active] 319795007651 domain IV; other site 319795007652 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 319795007653 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 319795007654 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 319795007655 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 319795007656 integral membrane protein MviN; Region: mviN; TIGR01695 319795007657 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 319795007658 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 319795007659 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 319795007660 HflX GTPase family; Region: HflX; cd01878 319795007661 G1 box; other site 319795007662 GTP/Mg2+ binding site [chemical binding]; other site 319795007663 Switch I region; other site 319795007664 G2 box; other site 319795007665 G3 box; other site 319795007666 Switch II region; other site 319795007667 G4 box; other site 319795007668 G5 box; other site 319795007669 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 319795007670 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795007671 DDE superfamily endonuclease; Region: DDE_4; pfam13359 319795007672 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 319795007673 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 319795007674 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 319795007675 NADP binding site [chemical binding]; other site 319795007676 active site 319795007677 putative substrate binding site [chemical binding]; other site 319795007678 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 319795007679 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 319795007680 PHP domain; Region: PHP; pfam02811 319795007681 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 319795007682 active site 319795007683 PHP-associated; Region: PHP_C; pfam13263 319795007684 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 319795007685 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 319795007686 Coenzyme A binding pocket [chemical binding]; other site 319795007687 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 319795007688 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 319795007689 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 319795007690 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 319795007691 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 319795007692 ATP binding site [chemical binding]; other site 319795007693 putative Mg++ binding site [ion binding]; other site 319795007694 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 319795007695 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 319795007696 Fic/DOC family; Region: Fic; pfam02661 319795007697 Protein of unknown function DUF262; Region: DUF262; pfam03235 319795007698 Uncharacterized conserved protein [Function unknown]; Region: COG1479 319795007699 Uncharacterized conserved protein [Function unknown]; Region: COG3472 319795007700 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 319795007701 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 319795007702 HsdM N-terminal domain; Region: HsdM_N; pfam12161 319795007703 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 319795007704 Methyltransferase domain; Region: Methyltransf_26; pfam13659 319795007705 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 319795007706 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 319795007707 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 319795007708 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 319795007709 Protein of unknown function (DUF3197); Region: DUF3197; pfam11432 319795007710 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 319795007711 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 319795007712 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 319795007713 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 319795007714 active site 319795007715 catalytic residues [active] 319795007716 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 319795007717 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 319795007718 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 319795007719 Uncharacterized conserved protein [Function unknown]; Region: COG2947 319795007720 Thymidylate synthase complementing protein; Region: Thy1; pfam02511 319795007721 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 319795007722 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 319795007723 Walker A/P-loop; other site 319795007724 ATP binding site [chemical binding]; other site 319795007725 Q-loop/lid; other site 319795007726 ABC transporter signature motif; other site 319795007727 Walker B; other site 319795007728 D-loop; other site 319795007729 H-loop/switch region; other site 319795007730 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 319795007731 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 319795007732 Walker A/P-loop; other site 319795007733 ATP binding site [chemical binding]; other site 319795007734 Q-loop/lid; other site 319795007735 ABC transporter signature motif; other site 319795007736 Walker B; other site 319795007737 D-loop; other site 319795007738 H-loop/switch region; other site 319795007739 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 319795007740 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 319795007741 putative ligand binding site [chemical binding]; other site 319795007742 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 319795007743 TM-ABC transporter signature motif; other site 319795007744 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 319795007745 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 319795007746 TM-ABC transporter signature motif; other site 319795007747 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 319795007748 ATP cone domain; Region: ATP-cone; pfam03477 319795007749 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 319795007750 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 319795007751 NAD(P) binding site [chemical binding]; other site 319795007752 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 319795007753 nudix motif; other site 319795007754 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 319795007755 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 319795007756 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 319795007757 Walker A motif; other site 319795007758 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 319795007759 protein-splicing catalytic site; other site 319795007760 thioester formation/cholesterol transfer; other site 319795007761 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 319795007762 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 319795007763 protein-splicing catalytic site; other site 319795007764 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 319795007765 ATP binding site [chemical binding]; other site 319795007766 Walker B motif; other site 319795007767 DNA binding loops [nucleotide binding] 319795007768 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 319795007769 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; cl01930 319795007770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 319795007771 S-adenosylmethionine binding site [chemical binding]; other site 319795007772 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14618 319795007773 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 319795007774 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 319795007775 Archaeal/vacuolar-type H+-ATPase subunit D [Energy production and conversion]; Region: NtpD; COG1394 319795007776 V-type ATP synthase subunit B; Provisional; Region: PRK04196 319795007777 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 319795007778 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 319795007779 Walker A motif homologous position; other site 319795007780 Walker B motif; other site 319795007781 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 319795007782 V-type ATP synthase subunit A; Provisional; Region: PRK04192 319795007783 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 319795007784 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 319795007785 Walker A motif/ATP binding site; other site 319795007786 Walker B motif; other site 319795007787 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 319795007788 Archaeal/vacuolar-type H+-ATPase subunit F [Energy production and conversion]; Region: NtpG; COG1436 319795007789 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 319795007790 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 319795007791 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 319795007792 V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074 319795007793 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 319795007794 Archaeal/vacuolar-type H+-ATPase subunit I [Energy production and conversion]; Region: NtpI; COG1269 319795007795 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 319795007796 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 319795007797 Nitrogen regulatory protein P-II; Region: P-II; smart00938 319795007798 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 319795007799 putative active site [active] 319795007800 catalytic residue [active] 319795007801 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 319795007802 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 319795007803 active site 319795007804 substrate binding site [chemical binding]; other site 319795007805 FMN binding site [chemical binding]; other site 319795007806 putative catalytic residues [active] 319795007807 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 319795007808 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 319795007809 active site 319795007810 DNA binding site [nucleotide binding] 319795007811 Int/Topo IB signature motif; other site 319795007812 catalytic residues [active] 319795007813 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 319795007814 ligand binding site [chemical binding]; other site 319795007815 active site 319795007816 UGI interface [polypeptide binding]; other site 319795007817 catalytic site [active] 319795007818 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 319795007819 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 319795007820 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 319795007821 catalytic site [active] 319795007822 subunit interface [polypeptide binding]; other site 319795007823 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 319795007824 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 319795007825 Coenzyme A binding pocket [chemical binding]; other site 319795007826 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 319795007827 Coenzyme A binding pocket [chemical binding]; other site 319795007828 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 319795007829 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 319795007830 Coenzyme A binding pocket [chemical binding]; other site 319795007831 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 319795007832 nucleotide binding site/active site [active] 319795007833 HIT family signature motif; other site 319795007834 catalytic residue [active] 319795007835 argininosuccinate lyase; Provisional; Region: PRK00855 319795007836 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 319795007837 active sites [active] 319795007838 tetramer interface [polypeptide binding]; other site 319795007839 putative acetyltransferase; Provisional; Region: PRK03624 319795007840 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 319795007841 Coenzyme A binding pocket [chemical binding]; other site 319795007842 argininosuccinate synthase; Provisional; Region: PRK13820 319795007843 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 319795007844 ANP binding site [chemical binding]; other site 319795007845 Substrate Binding Site II [chemical binding]; other site 319795007846 Substrate Binding Site I [chemical binding]; other site 319795007847 aminotransferase; Validated; Region: PRK07777 319795007848 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 319795007849 pyridoxal 5'-phosphate binding site [chemical binding]; other site 319795007850 homodimer interface [polypeptide binding]; other site 319795007851 catalytic residue [active] 319795007852 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 319795007853 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 319795007854 ATP-grasp domain; Region: ATP-grasp_4; cl17255 319795007855 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 319795007856 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 319795007857 ATP-grasp domain; Region: ATP-grasp_4; cl17255 319795007858 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 319795007859 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 319795007860 methionine sulfoxide reductase B; Provisional; Region: PRK00222 319795007861 SelR domain; Region: SelR; pfam01641 319795007862 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 319795007863 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 319795007864 catalytic residues [active] 319795007865 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 319795007866 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 319795007867 substrate binding pocket [chemical binding]; other site 319795007868 catalytic triad [active] 319795007869 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 319795007870 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 319795007871 Walker A motif; other site 319795007872 ATP binding site [chemical binding]; other site 319795007873 Walker B motif; other site 319795007874 arginine finger; other site 319795007875 Peptidase family M41; Region: Peptidase_M41; pfam01434 319795007876 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 319795007877 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 319795007878 nucleotide binding site [chemical binding]; other site 319795007879 NEF interaction site [polypeptide binding]; other site 319795007880 SBD interface [polypeptide binding]; other site 319795007881 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 319795007882 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 319795007883 dimer interface [polypeptide binding]; other site 319795007884 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 319795007885 chaperone protein DnaJ; Provisional; Region: PRK14299 319795007886 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 319795007887 HSP70 interaction site [polypeptide binding]; other site 319795007888 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 319795007889 substrate binding site [polypeptide binding]; other site 319795007890 dimer interface [polypeptide binding]; other site 319795007891 FOG: CBS domain [General function prediction only]; Region: COG0517 319795007892 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 319795007893 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 319795007894 active site 319795007895 catalytic residues [active] 319795007896 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 319795007897 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 319795007898 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 319795007899 intersubunit interface [polypeptide binding]; other site 319795007900 active site 319795007901 zinc binding site [ion binding]; other site 319795007902 Na+ binding site [ion binding]; other site 319795007903 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 319795007904 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 319795007905 pyridoxal 5'-phosphate binding site [chemical binding]; other site 319795007906 homodimer interface [polypeptide binding]; other site 319795007907 catalytic residue [active] 319795007908 glutamate racemase; Provisional; Region: PRK00865 319795007909 ribonuclease PH; Reviewed; Region: rph; PRK00173 319795007910 Ribonuclease PH; Region: RNase_PH_bact; cd11362 319795007911 hexamer interface [polypeptide binding]; other site 319795007912 active site 319795007913 Predicted membrane protein [Function unknown]; Region: COG2259 319795007914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 319795007915 S-adenosylmethionine binding site [chemical binding]; other site 319795007916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 319795007917 S-adenosylmethionine binding site [chemical binding]; other site 319795007918 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 319795007919 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 319795007920 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 319795007921 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 319795007922 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 319795007923 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 319795007924 Coenzyme A binding pocket [chemical binding]; other site 319795007925 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 319795007926 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 319795007927 active site 319795007928 phosphorylation site [posttranslational modification] 319795007929 intermolecular recognition site; other site 319795007930 dimerization interface [polypeptide binding]; other site 319795007931 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 319795007932 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 319795007933 dimer interface [polypeptide binding]; other site 319795007934 phosphorylation site [posttranslational modification] 319795007935 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 319795007936 ATP binding site [chemical binding]; other site 319795007937 Mg2+ binding site [ion binding]; other site 319795007938 G-X-G motif; other site 319795007939 Response regulator receiver domain; Region: Response_reg; pfam00072 319795007940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 319795007941 active site 319795007942 phosphorylation site [posttranslational modification] 319795007943 intermolecular recognition site; other site 319795007944 dimerization interface [polypeptide binding]; other site 319795007945 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 319795007946 PAS fold; Region: PAS_3; pfam08447 319795007947 putative active site [active] 319795007948 heme pocket [chemical binding]; other site 319795007949 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 319795007950 dimer interface [polypeptide binding]; other site 319795007951 phosphorylation site [posttranslational modification] 319795007952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 319795007953 ATP binding site [chemical binding]; other site 319795007954 Mg2+ binding site [ion binding]; other site 319795007955 G-X-G motif; other site 319795007956 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 319795007957 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 319795007958 FeS/SAM binding site; other site 319795007959 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 319795007960 DinB family; Region: DinB; cl17821 319795007961 DinB superfamily; Region: DinB_2; pfam12867 319795007962 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 319795007963 DNA binding site [nucleotide binding] 319795007964 active site 319795007965 Cytochrome c; Region: Cytochrom_C; pfam00034 319795007966 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 319795007967 GTP-binding protein Der; Reviewed; Region: PRK00093 319795007968 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 319795007969 G1 box; other site 319795007970 GTP/Mg2+ binding site [chemical binding]; other site 319795007971 Switch I region; other site 319795007972 G2 box; other site 319795007973 Switch II region; other site 319795007974 G3 box; other site 319795007975 G4 box; other site 319795007976 G5 box; other site 319795007977 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 319795007978 G1 box; other site 319795007979 GTP/Mg2+ binding site [chemical binding]; other site 319795007980 Switch I region; other site 319795007981 G2 box; other site 319795007982 G3 box; other site 319795007983 Switch II region; other site 319795007984 G4 box; other site 319795007985 G5 box; other site 319795007986 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 319795007987 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 319795007988 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 319795007989 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 319795007990 Dynamin family; Region: Dynamin_N; pfam00350 319795007991 G1 box; other site 319795007992 GTP/Mg2+ binding site [chemical binding]; other site 319795007993 G2 box; other site 319795007994 Switch I region; other site 319795007995 G3 box; other site 319795007996 Switch II region; other site 319795007997 G4 box; other site 319795007998 G5 box; other site 319795007999 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795008000 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 319795008001 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 319795008002 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 319795008003 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 319795008004 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 319795008005 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 319795008006 Protein of unknown function DUF45; Region: DUF45; cl00636 319795008007 Predicted metalloprotease [General function prediction only]; Region: COG2321 319795008008 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 319795008009 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 319795008010 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 319795008011 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 319795008012 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 319795008013 HlyD family secretion protein; Region: HlyD_3; pfam13437 319795008014 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 319795008015 Outer membrane efflux protein; Region: OEP; pfam02321 319795008016 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 319795008017 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 319795008018 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 319795008019 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 319795008020 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 319795008021 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 319795008022 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 319795008023 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 319795008024 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795008025 dimer interface [polypeptide binding]; other site 319795008026 conserved gate region; other site 319795008027 putative PBP binding loops; other site 319795008028 ABC-ATPase subunit interface; other site 319795008029 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 319795008030 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 319795008031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795008032 dimer interface [polypeptide binding]; other site 319795008033 conserved gate region; other site 319795008034 putative PBP binding loops; other site 319795008035 ABC-ATPase subunit interface; other site 319795008036 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 319795008037 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 319795008038 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 319795008039 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 319795008040 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 319795008041 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 319795008042 tRNA; other site 319795008043 putative tRNA binding site [nucleotide binding]; other site 319795008044 putative NADP binding site [chemical binding]; other site 319795008045 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 319795008046 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 319795008047 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 319795008048 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 319795008049 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 319795008050 active site 319795008051 SAM binding site [chemical binding]; other site 319795008052 homodimer interface [polypeptide binding]; other site 319795008053 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 319795008054 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 319795008055 active site 319795008056 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 319795008057 putative active site pocket [active] 319795008058 cleavage site 319795008059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 319795008060 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 319795008061 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14963 319795008062 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 319795008063 Walker A motif; other site 319795008064 ATP binding site [chemical binding]; other site 319795008065 Walker B motif; other site 319795008066 DNA polymerase III subunit delta'; Validated; Region: PRK08485 319795008067 arginine finger; other site 319795008068 competence damage-inducible protein A; Provisional; Region: PRK00549 319795008069 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 319795008070 putative MPT binding site; other site 319795008071 Competence-damaged protein; Region: CinA; cl00666 319795008072 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 319795008073 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 319795008074 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 319795008075 recombinase A; Provisional; Region: recA; PRK09354 319795008076 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 319795008077 hexamer interface [polypeptide binding]; other site 319795008078 Walker A motif; other site 319795008079 ATP binding site [chemical binding]; other site 319795008080 Walker B motif; other site 319795008081 BioY family; Region: BioY; pfam02632 319795008082 HTH domain; Region: HTH_11; cl17392 319795008083 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 319795008084 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 319795008085 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 319795008086 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 319795008087 metal binding site 2 [ion binding]; metal-binding site 319795008088 putative DNA binding helix; other site 319795008089 metal binding site 1 [ion binding]; metal-binding site 319795008090 dimer interface [polypeptide binding]; other site 319795008091 structural Zn2+ binding site [ion binding]; other site 319795008092 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 319795008093 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 319795008094 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 319795008095 active site 319795008096 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 319795008097 Response regulator receiver domain; Region: Response_reg; pfam00072 319795008098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 319795008099 active site 319795008100 phosphorylation site [posttranslational modification] 319795008101 intermolecular recognition site; other site 319795008102 dimerization interface [polypeptide binding]; other site 319795008103 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 319795008104 putative active site [active] 319795008105 PAS fold; Region: PAS_3; pfam08447 319795008106 heme pocket [chemical binding]; other site 319795008107 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 319795008108 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 319795008109 putative active site [active] 319795008110 heme pocket [chemical binding]; other site 319795008111 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 319795008112 dimer interface [polypeptide binding]; other site 319795008113 phosphorylation site [posttranslational modification] 319795008114 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 319795008115 ATP binding site [chemical binding]; other site 319795008116 Mg2+ binding site [ion binding]; other site 319795008117 G-X-G motif; other site 319795008118 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 319795008119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 319795008120 active site 319795008121 phosphorylation site [posttranslational modification] 319795008122 intermolecular recognition site; other site 319795008123 dimerization interface [polypeptide binding]; other site 319795008124 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 319795008125 DNA binding site [nucleotide binding] 319795008126 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 319795008127 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 319795008128 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 319795008129 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 319795008130 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 319795008131 oligomer interface [polypeptide binding]; other site 319795008132 active site residues [active] 319795008133 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 319795008134 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 319795008135 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 319795008136 Walker A motif; other site 319795008137 ATP binding site [chemical binding]; other site 319795008138 Walker B motif; other site 319795008139 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 319795008140 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 319795008141 Found in ATP-dependent protease La (LON); Region: LON; smart00464 319795008142 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 319795008143 Walker A motif; other site 319795008144 ATP binding site [chemical binding]; other site 319795008145 Walker B motif; other site 319795008146 arginine finger; other site 319795008147 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 319795008148 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 319795008149 malate dehydrogenase; Provisional; Region: PRK13529 319795008150 Malic enzyme, N-terminal domain; Region: malic; pfam00390 319795008151 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 319795008152 NAD(P) binding site [chemical binding]; other site 319795008153 malate dehydrogenase; Provisional; Region: PRK13529 319795008154 Malic enzyme, N-terminal domain; Region: malic; pfam00390 319795008155 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 319795008156 NAD(P) binding site [chemical binding]; other site 319795008157 Predicted thioesterase [General function prediction only]; Region: COG5496 319795008158 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 319795008159 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 319795008160 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 319795008161 catalytic residues [active] 319795008162 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 319795008163 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 319795008164 DNA binding residues [nucleotide binding] 319795008165 drug binding residues [chemical binding]; other site 319795008166 dimer interface [polypeptide binding]; other site 319795008167 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 319795008168 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 319795008169 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 319795008170 putative ADP-binding pocket [chemical binding]; other site 319795008171 malate dehydrogenase; Provisional; Region: PRK05442 319795008172 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 319795008173 NAD(P) binding site [chemical binding]; other site 319795008174 dimer interface [polypeptide binding]; other site 319795008175 malate binding site [chemical binding]; other site 319795008176 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 319795008177 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 319795008178 substrate binding site [chemical binding]; other site 319795008179 oxyanion hole (OAH) forming residues; other site 319795008180 trimer interface [polypeptide binding]; other site 319795008181 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 319795008182 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 319795008183 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 319795008184 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336 319795008185 putative ligand binding site [chemical binding]; other site 319795008186 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 319795008187 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 319795008188 TM-ABC transporter signature motif; other site 319795008189 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 319795008190 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 319795008191 TM-ABC transporter signature motif; other site 319795008192 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 319795008193 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 319795008194 Walker A/P-loop; other site 319795008195 ATP binding site [chemical binding]; other site 319795008196 Q-loop/lid; other site 319795008197 ABC transporter signature motif; other site 319795008198 Walker B; other site 319795008199 D-loop; other site 319795008200 H-loop/switch region; other site 319795008201 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 319795008202 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 319795008203 Walker A/P-loop; other site 319795008204 ATP binding site [chemical binding]; other site 319795008205 Q-loop/lid; other site 319795008206 ABC transporter signature motif; other site 319795008207 Walker B; other site 319795008208 D-loop; other site 319795008209 H-loop/switch region; other site 319795008210 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 319795008211 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 319795008212 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 319795008213 active site 319795008214 catalytic tetrad [active] 319795008215 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 319795008216 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 319795008217 putative DNA binding site [nucleotide binding]; other site 319795008218 putative Zn2+ binding site [ion binding]; other site 319795008219 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 319795008220 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 319795008221 active site 319795008222 phosphorylation site [posttranslational modification] 319795008223 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 319795008224 dimerization domain swap beta strand [polypeptide binding]; other site 319795008225 regulatory protein interface [polypeptide binding]; other site 319795008226 active site 319795008227 regulatory phosphorylation site [posttranslational modification]; other site 319795008228 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 319795008229 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 319795008230 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 319795008231 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 319795008232 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 319795008233 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 319795008234 putative substrate binding site [chemical binding]; other site 319795008235 putative ATP binding site [chemical binding]; other site 319795008236 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 319795008237 active site 319795008238 P-loop; other site 319795008239 phosphorylation site [posttranslational modification] 319795008240 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 319795008241 active site 319795008242 P-loop; other site 319795008243 phosphorylation site [posttranslational modification] 319795008244 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 319795008245 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; pfam03255 319795008246 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 319795008247 acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Region: accD; TIGR00515 319795008248 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 319795008249 PAS domain; Region: PAS_9; pfam13426 319795008250 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 319795008251 putative active site [active] 319795008252 heme pocket [chemical binding]; other site 319795008253 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 319795008254 GAF domain; Region: GAF; pfam01590 319795008255 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 319795008256 GAF domain; Region: GAF; pfam01590 319795008257 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 319795008258 dimer interface [polypeptide binding]; other site 319795008259 phosphorylation site [posttranslational modification] 319795008260 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 319795008261 ATP binding site [chemical binding]; other site 319795008262 Mg2+ binding site [ion binding]; other site 319795008263 G-X-G motif; other site 319795008264 Thymidine phosphorylase [Nucleotide transport and metabolism]; Region: DeoA; COG0213 319795008265 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 319795008266 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 319795008267 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 319795008268 Low affinity iron permease; Region: Iron_permease; cl12096 319795008269 FtsH Extracellular; Region: FtsH_ext; pfam06480 319795008270 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 319795008271 Preprotein translocase subunit; Region: YajC; cl00806 319795008272 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 319795008273 Walker A motif; other site 319795008274 ATP binding site [chemical binding]; other site 319795008275 Walker B motif; other site 319795008276 arginine finger; other site 319795008277 Peptidase family M41; Region: Peptidase_M41; pfam01434 319795008278 Tetratricopeptide repeat; Region: TPR_12; pfam13424 319795008279 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 319795008280 binding surface 319795008281 TPR motif; other site 319795008282 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 319795008283 putative active site pocket [active] 319795008284 dimerization interface [polypeptide binding]; other site 319795008285 putative catalytic residue [active] 319795008286 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 319795008287 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 319795008288 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 319795008289 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 319795008290 Coenzyme A binding pocket [chemical binding]; other site 319795008291 RAP domain; Region: RAP; cl17746 319795008292 glutaminyl-tRNA synthetase/YqeY domain fusion protein; Provisional; Region: PRK14703 319795008293 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 319795008294 active site 319795008295 HIGH motif; other site 319795008296 nucleotide binding site [chemical binding]; other site 319795008297 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 319795008298 KMSKS motif; other site 319795008299 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 319795008300 GatB domain; Region: GatB_Yqey; smart00845 319795008301 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 319795008302 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 319795008303 substrate binding pocket [chemical binding]; other site 319795008304 membrane-bound complex binding site; other site 319795008305 hinge residues; other site 319795008306 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 319795008307 16S/18S rRNA binding site [nucleotide binding]; other site 319795008308 S13e-L30e interaction site [polypeptide binding]; other site 319795008309 25S rRNA binding site [nucleotide binding]; other site 319795008310 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 319795008311 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795008312 DDE superfamily endonuclease; Region: DDE_4; pfam13359 319795008313 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 319795008314 active site clefts [active] 319795008315 zinc binding site [ion binding]; other site 319795008316 dimer interface [polypeptide binding]; other site 319795008317 hypothetical protein; Validated; Region: PRK00110 319795008318 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 319795008319 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 319795008320 putative hemin binding site; other site 319795008321 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 319795008322 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 319795008323 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795008324 DDE superfamily endonuclease; Region: DDE_4; pfam13359 319795008325 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 319795008326 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 319795008327 active site 319795008328 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 319795008329 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 319795008330 active site 319795008331 phosphorylation site [posttranslational modification] 319795008332 intermolecular recognition site; other site 319795008333 dimerization interface [polypeptide binding]; other site 319795008334 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 319795008335 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 319795008336 motif 1; other site 319795008337 active site 319795008338 motif 2; other site 319795008339 motif 3; other site 319795008340 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 319795008341 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 319795008342 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 319795008343 DNA binding residues [nucleotide binding] 319795008344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 319795008345 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795008346 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 319795008347 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 319795008348 active site residue [active] 319795008349 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 319795008350 active site residue [active] 319795008351 Fe-S metabolism associated domain; Region: SufE; cl00951 319795008352 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 319795008353 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795008354 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 319795008355 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 319795008356 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 319795008357 active site 319795008358 dimerization interface [polypeptide binding]; other site 319795008359 Protein of unknown function (DUF1045); Region: DUF1045; cl15435 319795008360 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 319795008361 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 319795008362 Cl binding site [ion binding]; other site 319795008363 oligomer interface [polypeptide binding]; other site 319795008364 Ferredoxin [Energy production and conversion]; Region: COG1146 319795008365 4Fe-4S binding domain; Region: Fer4; cl02805 319795008366 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 319795008367 active site 319795008368 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 319795008369 HAMP domain; Region: HAMP; pfam00672 319795008370 dimerization interface [polypeptide binding]; other site 319795008371 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 319795008372 dimer interface [polypeptide binding]; other site 319795008373 phosphorylation site [posttranslational modification] 319795008374 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 319795008375 ATP binding site [chemical binding]; other site 319795008376 Mg2+ binding site [ion binding]; other site 319795008377 G-X-G motif; other site 319795008378 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 319795008379 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 319795008380 active site 319795008381 phosphorylation site [posttranslational modification] 319795008382 intermolecular recognition site; other site 319795008383 dimerization interface [polypeptide binding]; other site 319795008384 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 319795008385 DNA binding site [nucleotide binding] 319795008386 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 319795008387 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 319795008388 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 319795008389 GTPase CgtA; Reviewed; Region: obgE; PRK12297 319795008390 GTP1/OBG; Region: GTP1_OBG; pfam01018 319795008391 Obg GTPase; Region: Obg; cd01898 319795008392 G1 box; other site 319795008393 GTP/Mg2+ binding site [chemical binding]; other site 319795008394 Switch I region; other site 319795008395 G2 box; other site 319795008396 G3 box; other site 319795008397 Switch II region; other site 319795008398 G4 box; other site 319795008399 G5 box; other site 319795008400 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 319795008401 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 319795008402 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 319795008403 active site 319795008404 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 319795008405 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 319795008406 CMP-binding site; other site 319795008407 The sites determining sugar specificity; other site 319795008408 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 319795008409 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 319795008410 putative acyl-acceptor binding pocket; other site 319795008411 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 319795008412 Peptidase S8 family domain, uncharacterized subfamily 5; Region: Peptidases_S8_5; cd07489 319795008413 active site 319795008414 catalytic triad [active] 319795008415 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 319795008416 putative integrin binding motif; other site 319795008417 PA/protease domain interface [polypeptide binding]; other site 319795008418 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 319795008419 catalytic residues [active] 319795008420 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 319795008421 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 319795008422 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 319795008423 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 319795008424 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 319795008425 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 319795008426 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 319795008427 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 319795008428 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 319795008429 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 319795008430 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 319795008431 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 319795008432 active site 319795008433 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 319795008434 Peptidase family M23; Region: Peptidase_M23; pfam01551 319795008435 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 319795008436 catalytic core [active] 319795008437 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 319795008438 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 319795008439 metal binding site [ion binding]; metal-binding site 319795008440 active site 319795008441 I-site; other site 319795008442 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 319795008443 oligomerisation interface [polypeptide binding]; other site 319795008444 mobile loop; other site 319795008445 roof hairpin; other site 319795008446 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 319795008447 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 319795008448 ring oligomerisation interface [polypeptide binding]; other site 319795008449 ATP/Mg binding site [chemical binding]; other site 319795008450 stacking interactions; other site 319795008451 hinge regions; other site 319795008452 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04135 319795008453 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 319795008454 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 319795008455 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 319795008456 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 319795008457 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 319795008458 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 319795008459 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 319795008460 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 319795008461 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 319795008462 classical (c) SDRs; Region: SDR_c; cd05233 319795008463 NAD(P) binding site [chemical binding]; other site 319795008464 active site 319795008465 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 319795008466 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 319795008467 active site 319795008468 catalytic tetrad [active] 319795008469 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 319795008470 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 319795008471 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 319795008472 Metallopeptidase family M24; Region: Peptidase_M24; pfam00557 319795008473 active site 319795008474 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 319795008475 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 319795008476 NAD binding site [chemical binding]; other site 319795008477 homodimer interface [polypeptide binding]; other site 319795008478 active site 319795008479 substrate binding site [chemical binding]; other site 319795008480 Transcriptional regulators [Transcription]; Region: PurR; COG1609 319795008481 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 319795008482 DNA binding site [nucleotide binding] 319795008483 domain linker motif; other site 319795008484 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 319795008485 putative dimerization interface [polypeptide binding]; other site 319795008486 putative ligand binding site [chemical binding]; other site 319795008487 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 319795008488 Helix-turn-helix domain; Region: HTH_17; pfam12728 319795008489 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 319795008490 active site 319795008491 coenzyme A binding site [chemical binding]; other site 319795008492 citrylCoA binding site [chemical binding]; other site 319795008493 dimer interface [polypeptide binding]; other site 319795008494 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 319795008495 oxalacetate/citrate binding site [chemical binding]; other site 319795008496 catalytic triad [active] 319795008497 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 319795008498 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 319795008499 active site 319795008500 catalytic residues [active] 319795008501 metal binding site [ion binding]; metal-binding site 319795008502 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 319795008503 S-ribosylhomocysteinase; Provisional; Region: PRK02260 319795008504 lipoprotein signal peptidase; Provisional; Region: PRK14777 319795008505 lipoprotein signal peptidase; Provisional; Region: PRK14787 319795008506 ribosomal protein L28; Region: L28; TIGR00009 319795008507 Predicted membrane protein [Function unknown]; Region: COG2261 319795008508 threonine synthase; Reviewed; Region: PRK06721 319795008509 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 319795008510 homodimer interface [polypeptide binding]; other site 319795008511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 319795008512 catalytic residue [active] 319795008513 homoserine kinase; Provisional; Region: PRK01212 319795008514 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 319795008515 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 319795008516 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 319795008517 Phosphotransferase enzyme family; Region: APH; pfam01636 319795008518 active site 319795008519 ATP binding site [chemical binding]; other site 319795008520 antibiotic binding site [chemical binding]; other site 319795008521 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 319795008522 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 319795008523 Predicted integral membrane protein [Function unknown]; Region: COG5530 319795008524 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 319795008525 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 319795008526 DNA polymerase III subunit delta'; Validated; Region: PRK08485 319795008527 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 319795008528 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 319795008529 active site 319795008530 metal binding site [ion binding]; metal-binding site 319795008531 Predicted amidohydrolase [General function prediction only]; Region: COG0388 319795008532 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 319795008533 putative active site [active] 319795008534 catalytic triad [active] 319795008535 putative dimer interface [polypeptide binding]; other site 319795008536 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 319795008537 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 319795008538 active site 319795008539 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 319795008540 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 319795008541 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 319795008542 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 319795008543 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 319795008544 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 319795008545 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 319795008546 DNA binding residues [nucleotide binding] 319795008547 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 319795008548 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 319795008549 Probable transposase; Region: OrfB_IS605; pfam01385 319795008550 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 319795008551 Transposase IS200 like; Region: Y1_Tnp; pfam01797 319795008552 HD domain; Region: HD_3; cl17350 319795008553 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 319795008554 synthetase active site [active] 319795008555 NTP binding site [chemical binding]; other site 319795008556 metal binding site [ion binding]; metal-binding site 319795008557 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 319795008558 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795008559 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 319795008560 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 319795008561 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 319795008562 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 319795008563 DNA binding site [nucleotide binding] 319795008564 Int/Topo IB signature motif; other site 319795008565 active site 319795008566 catalytic residues [active] 319795008567 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 319795008568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 319795008569 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 319795008570 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 319795008571 TPP-binding site [chemical binding]; other site 319795008572 dimer interface [polypeptide binding]; other site 319795008573 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 319795008574 PYR/PP interface [polypeptide binding]; other site 319795008575 dimer interface [polypeptide binding]; other site 319795008576 TPP binding site [chemical binding]; other site 319795008577 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 319795008578 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 319795008579 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 319795008580 catalytic site [active] 319795008581 G-X2-G-X-G-K; other site 319795008582 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 319795008583 AsnC family; Region: AsnC_trans_reg; pfam01037 319795008584 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 319795008585 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 319795008586 short chain dehydrogenase; Provisional; Region: PRK06701 319795008587 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 319795008588 NAD binding site [chemical binding]; other site 319795008589 metal binding site [ion binding]; metal-binding site 319795008590 active site 319795008591 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 319795008592 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 319795008593 minor groove reading motif; other site 319795008594 helix-hairpin-helix signature motif; other site 319795008595 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 319795008596 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 319795008597 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 319795008598 putative active site [active] 319795008599 substrate binding site [chemical binding]; other site 319795008600 putative cosubstrate binding site; other site 319795008601 catalytic site [active] 319795008602 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 319795008603 substrate binding site [chemical binding]; other site 319795008604 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 319795008605 active site 319795008606 catalytic residues [active] 319795008607 metal binding site [ion binding]; metal-binding site 319795008608 TPR repeat; Region: TPR_11; pfam13414 319795008609 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 319795008610 TPR motif; other site 319795008611 binding surface 319795008612 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 319795008613 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 319795008614 NAD binding site [chemical binding]; other site 319795008615 catalytic Zn binding site [ion binding]; other site 319795008616 structural Zn binding site [ion binding]; other site 319795008617 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 319795008618 dimerization interface [polypeptide binding]; other site 319795008619 metal binding site [ion binding]; metal-binding site 319795008620 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 319795008621 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 319795008622 DDE superfamily endonuclease; Region: DDE_5; cl17874 319795008623 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 319795008624 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 319795008625 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 319795008626 active site 319795008627 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 319795008628 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 319795008629 putative acyl-acceptor binding pocket; other site 319795008630 Protein of unknown function (DUF422); Region: DUF422; pfam04240 319795008631 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 319795008632 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 319795008633 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 319795008634 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 319795008635 Coenzyme A binding pocket [chemical binding]; other site 319795008636 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 319795008637 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 319795008638 active site 319795008639 Zn binding site [ion binding]; other site 319795008640 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 319795008641 Flavoprotein; Region: Flavoprotein; pfam02441 319795008642 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 319795008643 Arginine repressor [Transcription]; Region: ArgR; COG1438 319795008644 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 319795008645 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 319795008646 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 319795008647 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 319795008648 dimerization interface [polypeptide binding]; other site 319795008649 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 319795008650 dimer interface [polypeptide binding]; other site 319795008651 phosphorylation site [posttranslational modification] 319795008652 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 319795008653 ATP binding site [chemical binding]; other site 319795008654 Mg2+ binding site [ion binding]; other site 319795008655 G-X-G motif; other site 319795008656 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 319795008657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 319795008658 active site 319795008659 phosphorylation site [posttranslational modification] 319795008660 intermolecular recognition site; other site 319795008661 dimerization interface [polypeptide binding]; other site 319795008662 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 319795008663 DNA binding site [nucleotide binding] 319795008664 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 319795008665 cyclase homology domain; Region: CHD; cd07302 319795008666 nucleotidyl binding site; other site 319795008667 metal binding site [ion binding]; metal-binding site 319795008668 dimer interface [polypeptide binding]; other site 319795008669 putative 4-hydroxybenzoate polyprenyltransferase; Region: ubiA_other; TIGR01475 319795008670 UbiA prenyltransferase family; Region: UbiA; pfam01040 319795008671 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 319795008672 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 319795008673 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 319795008674 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 319795008675 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 319795008676 FeS/SAM binding site; other site 319795008677 HemN C-terminal domain; Region: HemN_C; pfam06969 319795008678 Uncharacterized conserved protein [Function unknown]; Region: COG2013 319795008679 Predicted membrane protein [Function unknown]; Region: COG2311 319795008680 Protein of unknown function (DUF418); Region: DUF418; pfam04235 319795008681 fumarate hydratase; Reviewed; Region: fumC; PRK00485 319795008682 Class II fumarases; Region: Fumarase_classII; cd01362 319795008683 active site 319795008684 tetramer interface [polypeptide binding]; other site 319795008685 Helix-turn-helix domain; Region: HTH_18; pfam12833 319795008686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 319795008687 Major Facilitator Superfamily; Region: MFS_1; pfam07690 319795008688 putative substrate translocation pore; other site 319795008689 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 319795008690 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 319795008691 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 319795008692 VanW like protein; Region: VanW; pfam04294 319795008693 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 319795008694 ParB-like nuclease domain; Region: ParB; smart00470 319795008695 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 319795008696 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 319795008697 P-loop; other site 319795008698 Magnesium ion binding site [ion binding]; other site 319795008699 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 319795008700 Magnesium ion binding site [ion binding]; other site 319795008701 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 319795008702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 319795008703 S-adenosylmethionine binding site [chemical binding]; other site 319795008704 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 319795008705 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 319795008706 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 319795008707 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 319795008708 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 319795008709 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 319795008710 TPP-binding site [chemical binding]; other site 319795008711 tetramer interface [polypeptide binding]; other site 319795008712 heterodimer interface [polypeptide binding]; other site 319795008713 phosphorylation loop region [posttranslational modification] 319795008714 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 319795008715 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 319795008716 alpha subunit interface [polypeptide binding]; other site 319795008717 TPP binding site [chemical binding]; other site 319795008718 heterodimer interface [polypeptide binding]; other site 319795008719 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 319795008720 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 319795008721 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 319795008722 E3 interaction surface; other site 319795008723 lipoyl attachment site [posttranslational modification]; other site 319795008724 e3 binding domain; Region: E3_binding; pfam02817 319795008725 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 319795008726 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 319795008727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 319795008728 active site 319795008729 phosphorylation site [posttranslational modification] 319795008730 intermolecular recognition site; other site 319795008731 dimerization interface [polypeptide binding]; other site 319795008732 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 319795008733 DNA binding site [nucleotide binding] 319795008734 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 319795008735 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 319795008736 ATP binding site [chemical binding]; other site 319795008737 G-X-G motif; other site 319795008738 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 319795008739 DNA protecting protein DprA; Region: dprA; TIGR00732 319795008740 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 319795008741 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795008742 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 319795008743 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795008744 DDE domain; Region: DDE_Tnp_IS240; pfam13610 319795008745 Integrase core domain; Region: rve; pfam00665 319795008746 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 319795008747 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 319795008748 active site 319795008749 homodimer interface [polypeptide binding]; other site 319795008750 catalytic site [active] 319795008751 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 319795008752 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 319795008753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795008754 dimer interface [polypeptide binding]; other site 319795008755 conserved gate region; other site 319795008756 putative PBP binding loops; other site 319795008757 ABC-ATPase subunit interface; other site 319795008758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795008759 dimer interface [polypeptide binding]; other site 319795008760 conserved gate region; other site 319795008761 putative PBP binding loops; other site 319795008762 ABC-ATPase subunit interface; other site 319795008763 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 319795008764 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 319795008765 Transcriptional regulators [Transcription]; Region: PurR; COG1609 319795008766 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 319795008767 DNA binding site [nucleotide binding] 319795008768 domain linker motif; other site 319795008769 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 319795008770 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 319795008771 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 319795008772 tetramer interface [polypeptide binding]; other site 319795008773 pyridoxal 5'-phosphate binding site [chemical binding]; other site 319795008774 catalytic residue [active] 319795008775 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 319795008776 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 319795008777 RNA/DNA hybrid binding site [nucleotide binding]; other site 319795008778 active site 319795008779 Divergent AAA domain; Region: AAA_4; pfam04326 319795008780 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 319795008781 AAA domain; Region: AAA_12; pfam13087 319795008782 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795008783 murein transglycosylase A; Provisional; Region: mltA; PRK11162 319795008784 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 319795008785 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 319795008786 SIR2-like domain; Region: SIR2_2; pfam13289 319795008787 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 319795008788 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 319795008789 Coenzyme A binding pocket [chemical binding]; other site 319795008790 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 319795008791 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 319795008792 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 319795008793 Catalytic domain of Protein Kinases; Region: PKc; cd00180 319795008794 active site 319795008795 ATP binding site [chemical binding]; other site 319795008796 substrate binding site [chemical binding]; other site 319795008797 activation loop (A-loop); other site 319795008798 AAA domain; Region: AAA_11; pfam13086 319795008799 Part of AAA domain; Region: AAA_19; pfam13245 319795008800 DDE domain; Region: DDE_Tnp_IS240; pfam13610 319795008801 Integrase core domain; Region: rve; pfam00665 319795008802 AAA-like domain; Region: AAA_10; pfam12846 319795008803 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 319795008804 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 319795008805 NADH dehydrogenase subunit E; Provisional; Region: PRK12373 319795008806 T-complex protein 10 C-terminus; Region: Tcp10_C; pfam07202 319795008807 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 319795008808 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 319795008809 N-acetyl-D-glucosamine binding site [chemical binding]; other site 319795008810 catalytic residue [active] 319795008811 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 319795008812 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 319795008813 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 319795008814 dimer interface [polypeptide binding]; other site 319795008815 ssDNA binding site [nucleotide binding]; other site 319795008816 tetramer (dimer of dimers) interface [polypeptide binding]; other site 319795008817 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 319795008818 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 319795008819 dimer interface [polypeptide binding]; other site 319795008820 ssDNA binding site [nucleotide binding]; other site 319795008821 tetramer (dimer of dimers) interface [polypeptide binding]; other site 319795008822 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 319795008823 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 319795008824 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 319795008825 dimer interface [polypeptide binding]; other site 319795008826 ssDNA binding site [nucleotide binding]; other site 319795008827 tetramer (dimer of dimers) interface [polypeptide binding]; other site 319795008828 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 319795008829 generic binding surface I; other site 319795008830 generic binding surface II; other site 319795008831 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 319795008832 Transcriptional regulator PadR-like family; Region: PadR; cl17335 319795008833 RES domain; Region: RES; pfam08808 319795008834 ParB-like nuclease domain; Region: ParB; smart00470 319795008835 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 319795008836 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 319795008837 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 319795008838 P-loop; other site 319795008839 Magnesium ion binding site [ion binding]; other site 319795008840 EamA-like transporter family; Region: EamA; pfam00892 319795008841 EamA-like transporter family; Region: EamA; pfam00892 319795008842 DdrB-like protein; Region: DdrB; pfam12747 319795008843 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 319795008844 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795008845 Transposase; Region: HTH_Tnp_1; pfam01527 319795008846 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 319795008847 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 319795008848 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 319795008849 DDE domain; Region: DDE_Tnp_IS240; pfam13610 319795008850 Integrase core domain; Region: rve; pfam00665 319795008851 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 319795008852 dimer interface [polypeptide binding]; other site 319795008853 Alkaline phosphatase homologues; Region: alkPPc; smart00098 319795008854 active site 319795008855 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 319795008856 ApbE family; Region: ApbE; pfam02424 319795008857 CCC1; Region: CCC1; cd02435 319795008858 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 319795008859 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 319795008860 dimerization interface [polypeptide binding]; other site 319795008861 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 319795008862 dimer interface [polypeptide binding]; other site 319795008863 phosphorylation site [posttranslational modification] 319795008864 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 319795008865 ATP binding site [chemical binding]; other site 319795008866 G-X-G motif; other site 319795008867 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 319795008868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 319795008869 active site 319795008870 phosphorylation site [posttranslational modification] 319795008871 intermolecular recognition site; other site 319795008872 dimerization interface [polypeptide binding]; other site 319795008873 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 319795008874 DNA binding site [nucleotide binding] 319795008875 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 319795008876 Helix-hairpin-helix motif; Region: HHH; pfam00633 319795008877 DDE domain; Region: DDE_Tnp_IS240; pfam13610 319795008878 Integrase core domain; Region: rve; pfam00665 319795008879 Phage portal protein; Region: Phage_portal; pfam04860 319795008880 DDE domain; Region: DDE_Tnp_IS240; pfam13610 319795008881 Integrase core domain; Region: rve; pfam00665 319795008882 Phage tail repeat like; Region: PTR; pfam12789 319795008883 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 319795008884 FOG: PKD repeat [General function prediction only]; Region: COG3291 319795008885 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 319795008886 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 319795008887 Baseplate J-like protein; Region: Baseplate_J; cl01294 319795008888 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 319795008889 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 319795008890 Peptidase family M23; Region: Peptidase_M23; pfam01551 319795008891 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 319795008892 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 319795008893 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 319795008894 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 319795008895 Probable transposase; Region: OrfB_IS605; pfam01385 319795008896 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 319795008897 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 319795008898 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 319795008899 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 319795008900 active site 319795008901 catalytic residues [active] 319795008902 DNA binding site [nucleotide binding] 319795008903 Int/Topo IB signature motif; other site 319795008904 HD domain; Region: HD_3; cl17350 319795008905 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 319795008906 group I intron endonuclease; Region: grpIintron_endo; TIGR01453 319795008907 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 319795008908 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 319795008909 DNA polymerase III subunit beta; Provisional; Region: PRK14945 319795008910 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 319795008911 putative DNA binding surface [nucleotide binding]; other site 319795008912 dimer interface [polypeptide binding]; other site 319795008913 beta-clamp/translesion DNA polymerase binding surface; other site 319795008914 beta-clamp/clamp loader binding surface; other site 319795008915 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 319795008916 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 319795008917 P-loop; other site 319795008918 Magnesium ion binding site [ion binding]; other site 319795008919 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 319795008920 Magnesium ion binding site [ion binding]; other site 319795008921 DDE domain; Region: DDE_Tnp_IS240; pfam13610 319795008922 Integrase core domain; Region: rve; pfam00665 319795008923 Methyltransferase domain; Region: Methyltransf_26; pfam13659 319795008924 DEAD-like helicases superfamily; Region: DEXDc; smart00487 319795008925 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 319795008926 DEAD-like helicases superfamily; Region: DEXDc; smart00487 319795008927 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 319795008928 ATP binding site [chemical binding]; other site 319795008929 putative Mg++ binding site [ion binding]; other site 319795008930 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 319795008931 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 319795008932 nucleotide binding region [chemical binding]; other site 319795008933 ATP-binding site [chemical binding]; other site 319795008934 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 319795008935 DDE domain; Region: DDE_Tnp_IS240; pfam13610 319795008936 Integrase core domain; Region: rve; pfam00665 319795008937 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 319795008938 generic binding surface II; other site 319795008939 generic binding surface I; other site 319795008940 DDE superfamily endonuclease; Region: DDE_5; cl17874 319795008941 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 319795008942 Replication initiator protein A; Region: RPA; cl17860 319795008943 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 319795008944 DNA-binding residues [nucleotide binding]; DNA binding site 319795008945 nucleotide binding site [chemical binding]; other site 319795008946 polymerase nucleotide-binding site; other site 319795008947 primase nucleotide-binding site [nucleotide binding]; other site 319795008948 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 319795008949 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 319795008950 AAA domain; Region: AAA_22; pfam13401 319795008951 Tetratricopeptide repeat; Region: TPR_12; pfam13424 319795008952 Transcriptional regulators [Transcription]; Region: PurR; COG1609 319795008953 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 319795008954 DNA binding site [nucleotide binding] 319795008955 domain linker motif; other site 319795008956 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 319795008957 dimerization interface [polypeptide binding]; other site 319795008958 ligand binding site [chemical binding]; other site 319795008959 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 319795008960 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 319795008961 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 319795008962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795008963 dimer interface [polypeptide binding]; other site 319795008964 conserved gate region; other site 319795008965 putative PBP binding loops; other site 319795008966 ABC-ATPase subunit interface; other site 319795008967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 319795008968 dimer interface [polypeptide binding]; other site 319795008969 conserved gate region; other site 319795008970 putative PBP binding loops; other site 319795008971 ABC-ATPase subunit interface; other site 319795008972 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 319795008973 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 319795008974 DDE superfamily endonuclease; Region: DDE_5; cl17874 319795008975 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 319795008976 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 319795008977 non-specific DNA binding site [nucleotide binding]; other site 319795008978 salt bridge; other site 319795008979 sequence-specific DNA binding site [nucleotide binding]; other site 319795008980 HsdM N-terminal domain; Region: HsdM_N; pfam12161 319795008981 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 319795008982 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 319795008983 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 319795008984 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 319795008985 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 319795008986 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 319795008987 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 319795008988 ATP binding site [chemical binding]; other site 319795008989 putative Mg++ binding site [ion binding]; other site 319795008990 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 319795008991 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609