-- dump date 20140619_060334 -- class Genbank::misc_feature -- table misc_feature_note -- id note 745776000001 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 745776000002 Catalytic site [active] 745776000003 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 745776000004 HsdM N-terminal domain; Region: HsdM_N; pfam12161 745776000005 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 745776000006 Methyltransferase domain; Region: Methyltransf_26; pfam13659 745776000007 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 745776000008 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 745776000009 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 745776000010 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 745776000011 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 745776000012 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 745776000013 TPR repeat; Region: TPR_11; pfam13414 745776000014 binding surface 745776000015 TPR motif; other site 745776000016 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 745776000017 TPR motif; other site 745776000018 binding surface 745776000019 TniQ; Region: TniQ; pfam06527 745776000020 Homeodomain-like domain; Region: HTH_23; pfam13384 745776000021 Winged helix-turn helix; Region: HTH_29; pfam13551 745776000022 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745776000023 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 745776000024 Walker A motif; other site 745776000025 ATP binding site [chemical binding]; other site 745776000026 Walker B motif; other site 745776000027 arginine finger; other site 745776000028 Winged helix-turn helix; Region: HTH_29; pfam13551 745776000029 Integrase core domain; Region: rve; pfam00665 745776000030 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 745776000031 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 745776000032 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 745776000033 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 745776000034 Methyltransferase domain; Region: Methyltransf_26; pfam13659 745776000035 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 745776000036 Prokaryotic Ubiquitin; Region: Prok_Ub; cl14020 745776000037 Prokaryotic E2 family D; Region: Prok-E2_D; cl14019 745776000038 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 745776000039 ATP binding site [chemical binding]; other site 745776000040 substrate interface [chemical binding]; other site 745776000041 Replication initiator protein A; Region: RPA; cl17860 745776000042 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 745776000043 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 745776000044 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 745776000045 active site 745776000046 Int/Topo IB signature motif; other site 745776000047 catalytic residues [active] 745776000048 DNA binding site [nucleotide binding] 745776000049 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 745776000050 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 745776000051 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 745776000052 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 745776000053 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 745776000054 Beta-Casp domain; Region: Beta-Casp; smart01027 745776000055 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 745776000056 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 745776000057 Zn2+ binding site [ion binding]; other site 745776000058 Mg2+ binding site [ion binding]; other site 745776000059 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; cl01017 745776000060 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 745776000061 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 745776000062 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776000063 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776000064 Walker A/P-loop; other site 745776000065 Walker A/P-loop; other site 745776000066 ATP binding site [chemical binding]; other site 745776000067 ATP binding site [chemical binding]; other site 745776000068 Q-loop/lid; other site 745776000069 Walker B; other site 745776000070 H-loop/switch region; other site 745776000071 DDE superfamily endonuclease; Region: DDE_3; pfam13358 745776000072 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 745776000073 PQQ-like domain; Region: PQQ_2; pfam13360 745776000074 PQQ-like domain; Region: PQQ_2; pfam13360 745776000075 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 745776000076 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 745776000077 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 745776000078 DDE superfamily endonuclease; Region: DDE_5; cl17874 745776000079 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 745776000080 Predicted transcriptional regulator [Transcription]; Region: COG1959 745776000081 Transcriptional regulator; Region: Rrf2; pfam02082 745776000082 Predicted oxidoreductase [General function prediction only]; Region: COG3573 745776000083 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 745776000084 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745776000085 S-adenosylmethionine binding site [chemical binding]; other site 745776000086 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 745776000087 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 745776000088 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 745776000089 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 745776000090 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 745776000091 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 745776000092 ADP-ribose binding site [chemical binding]; other site 745776000093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719 745776000094 conserved repeat domain; Region: B_ant_repeat; TIGR01451 745776000095 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 745776000096 G2 box; other site 745776000097 Switch I region; other site 745776000098 G3 box; other site 745776000099 Switch II region; other site 745776000100 GTP/Mg2+ binding site [chemical binding]; other site 745776000101 G4 box; other site 745776000102 G5 box; other site 745776000103 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 745776000104 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745776000105 non-specific DNA binding site [nucleotide binding]; other site 745776000106 salt bridge; other site 745776000107 sequence-specific DNA binding site [nucleotide binding]; other site 745776000108 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 745776000109 IHF dimer interface [polypeptide binding]; other site 745776000110 IHF - DNA interface [nucleotide binding]; other site 745776000111 Protein of unknown function DUF91; Region: DUF91; cl00709 745776000112 Fic/DOC family; Region: Fic; pfam02661 745776000113 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 745776000114 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 745776000115 dimer interface [polypeptide binding]; other site 745776000116 ssDNA binding site [nucleotide binding]; other site 745776000117 tetramer (dimer of dimers) interface [polypeptide binding]; other site 745776000118 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 745776000119 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 745776000120 dimer interface [polypeptide binding]; other site 745776000121 ssDNA binding site [nucleotide binding]; other site 745776000122 tetramer (dimer of dimers) interface [polypeptide binding]; other site 745776000123 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 745776000124 generic binding surface II; other site 745776000125 generic binding surface I; other site 745776000126 Zeta toxin; Region: Zeta_toxin; pfam06414 745776000127 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 745776000128 Domain of unknown function (DUF4326); Region: DUF4326; pfam14216 745776000129 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 745776000130 active site 745776000131 catalytic triad [active] 745776000132 dimer interface [polypeptide binding]; other site 745776000133 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 745776000134 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 745776000135 active site residue [active] 745776000136 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 745776000137 active site residue [active] 745776000138 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745776000139 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745776000140 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 745776000141 dimerization interface [polypeptide binding]; other site 745776000142 Erythromycin esterase; Region: Erythro_esteras; pfam05139 745776000143 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 745776000144 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745776000145 non-specific DNA binding site [nucleotide binding]; other site 745776000146 salt bridge; other site 745776000147 sequence-specific DNA binding site [nucleotide binding]; other site 745776000148 Chorismate mutase type II; Region: CM_2; cl00693 745776000149 DNA polymerase elongation subunit (family B) [DNA replication, recombination, and repair]; Region: PolB; COG0417 745776000150 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 745776000151 active site 745776000152 catalytic site [active] 745776000153 substrate binding site [chemical binding]; other site 745776000154 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 745776000155 active site 745776000156 metal-binding site 745776000157 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 745776000158 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 745776000159 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 745776000160 IHF dimer interface [polypeptide binding]; other site 745776000161 IHF - DNA interface [nucleotide binding]; other site 745776000162 ParB-like nuclease domain; Region: ParBc; pfam02195 745776000163 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 745776000164 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 745776000165 P-loop; other site 745776000166 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 745776000167 Magnesium ion binding site [ion binding]; other site 745776000168 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 745776000169 Magnesium ion binding site [ion binding]; other site 745776000170 ParB-like nuclease domain; Region: ParBc; pfam02195 745776000171 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 745776000172 PcfJ-like protein; Region: PcfJ; pfam14284 745776000173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 745776000174 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 745776000175 metal ion-dependent adhesion site (MIDAS); other site 745776000176 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 745776000177 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 745776000178 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 745776000179 Winged helix-turn helix; Region: HTH_33; pfam13592 745776000180 DDE superfamily endonuclease; Region: DDE_3; pfam13358 745776000181 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 745776000182 Peptidase family M23; Region: Peptidase_M23; pfam01551 745776000183 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 745776000184 dimerization interface [polypeptide binding]; other site 745776000185 Domain of unknown function (DUF305); Region: DUF305; pfam03713 745776000186 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 745776000187 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 745776000188 Soluble P-type ATPase [General function prediction only]; Region: COG4087 745776000189 Domain of unknown function (DUF305); Region: DUF305; pfam03713 745776000190 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 745776000191 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 745776000192 dimerization interface [polypeptide binding]; other site 745776000193 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745776000194 dimer interface [polypeptide binding]; other site 745776000195 phosphorylation site [posttranslational modification] 745776000196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776000197 ATP binding site [chemical binding]; other site 745776000198 Mg2+ binding site [ion binding]; other site 745776000199 G-X-G motif; other site 745776000200 Ycf48-like protein; Provisional; Region: PRK13684 745776000201 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 745776000202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776000203 active site 745776000204 phosphorylation site [posttranslational modification] 745776000205 intermolecular recognition site; other site 745776000206 dimerization interface [polypeptide binding]; other site 745776000207 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 745776000208 DNA binding site [nucleotide binding] 745776000209 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 745776000210 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 745776000211 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 745776000212 Transposase; Region: HTH_Tnp_1; pfam01527 745776000213 Integrase core domain; Region: rve_3; cl15866 745776000214 YibE/F-like protein; Region: YibE_F; cl02259 745776000215 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 745776000216 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 745776000217 active site 745776000218 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 745776000219 Domain of unknown function (DUF305); Region: DUF305; pfam03713 745776000220 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 745776000221 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 745776000222 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 745776000223 Leucine carboxyl methyltransferase; Region: LCM; cl01306 745776000224 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 745776000225 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 745776000226 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 745776000227 dimerization interface [polypeptide binding]; other site 745776000228 putative DNA binding site [nucleotide binding]; other site 745776000229 putative Zn2+ binding site [ion binding]; other site 745776000230 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 745776000231 catalytic residues [active] 745776000232 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 745776000233 metal-binding site [ion binding] 745776000234 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 745776000235 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 745776000236 metal-binding site [ion binding] 745776000237 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 745776000238 Soluble P-type ATPase [General function prediction only]; Region: COG4087 745776000239 DDE superfamily endonuclease; Region: DDE_5; cl17874 745776000240 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 745776000241 Integrase core domain; Region: rve; pfam00665 745776000242 Integrase core domain; Region: rve_3; pfam13683 745776000243 HTH-like domain; Region: HTH_21; pfam13276 745776000244 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 745776000245 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 745776000246 metal-binding site [ion binding] 745776000247 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 745776000248 Soluble P-type ATPase [General function prediction only]; Region: COG4087 745776000249 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 745776000250 catalytic residues [active] 745776000251 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 745776000252 Predicted amidohydrolase [General function prediction only]; Region: COG0388 745776000253 putative active site [active] 745776000254 catalytic triad [active] 745776000255 putative dimer interface [polypeptide binding]; other site 745776000256 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 745776000257 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 745776000258 Peptidase family M23; Region: Peptidase_M23; pfam01551 745776000259 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 745776000260 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 745776000261 Domain of unknown function (DUF305); Region: DUF305; pfam03713 745776000262 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 745776000263 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 745776000264 putative DNA binding site [nucleotide binding]; other site 745776000265 putative Zn2+ binding site [ion binding]; other site 745776000266 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 745776000267 dimerization interface [polypeptide binding]; other site 745776000268 putative DNA binding site [nucleotide binding]; other site 745776000269 putative Zn2+ binding site [ion binding]; other site 745776000270 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 745776000271 Low molecular weight phosphatase family; Region: LMWPc; cd00115 745776000272 active site 745776000273 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 745776000274 arsenical pump membrane protein; Provisional; Region: PRK15445 745776000275 transmembrane helices; other site 745776000276 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 745776000277 Low molecular weight phosphatase family; Region: LMWPc; cl00105 745776000278 active site 745776000279 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 745776000280 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 745776000281 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 745776000282 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 745776000283 Methyltransferase domain; Region: Methyltransf_26; pfam13659 745776000284 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 745776000285 nucleotide binding region [chemical binding]; other site 745776000286 ATP-binding site [chemical binding]; other site 745776000287 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 745776000288 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 745776000289 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 745776000290 active site 745776000291 catalytic residues [active] 745776000292 DNA binding site [nucleotide binding] 745776000293 Int/Topo IB signature motif; other site 745776000294 potential frameshift: common BLAST hit: gi|331699799|ref|YP_004336038.1| integrase protein 745776000295 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 745776000296 DNA binding site [nucleotide binding] 745776000297 Int/Topo IB signature motif; other site 745776000298 active site 745776000299 catalytic residues [active] 745776000300 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745776000301 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745776000302 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 745776000303 dimerization interface [polypeptide binding]; other site 745776000304 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 745776000305 gating phenylalanine in ion channel; other site 745776000306 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 745776000307 sulfite oxidase; Provisional; Region: PLN00177 745776000308 Moco binding site; other site 745776000309 metal coordination site [ion binding]; other site 745776000310 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 745776000311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 745776000312 phosphorylation site [posttranslational modification] 745776000313 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 745776000314 dimerization interface [polypeptide binding]; other site 745776000315 DNA binding residues [nucleotide binding] 745776000316 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 745776000317 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 745776000318 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 745776000319 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 745776000320 Domain of unknown function (DUF305); Region: DUF305; cl17794 745776000321 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 745776000322 Transposase; Region: HTH_Tnp_1; cl17663 745776000323 putative transposase OrfB; Reviewed; Region: PHA02517 745776000324 HTH-like domain; Region: HTH_21; pfam13276 745776000325 Integrase core domain; Region: rve; pfam00665 745776000326 Integrase core domain; Region: rve_3; pfam13683 745776000327 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 745776000328 potential frameshift: common BLAST hit: gi|325282589|ref|YP_004255130.1| transposase IS4 family protein 745776000329 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 745776000330 RNAase interaction site [polypeptide binding]; other site 745776000331 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 745776000332 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 745776000333 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 745776000334 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 745776000335 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 745776000336 Putative zinc-finger; Region: zf-HC2; pfam13490 745776000337 putative anti-sigmaE protein; Provisional; Region: PRK13920 745776000338 Anti-sigma-K factor rskA; Region: RskA; pfam10099 745776000339 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 745776000340 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 745776000341 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 745776000342 DNA binding residues [nucleotide binding] 745776000343 High-affinity nickel-transport protein; Region: NicO; cl00964 745776000344 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 745776000345 ATP-dependent DNA helicase; Q4-like; Provisional; Region: PLN03137 745776000346 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 745776000347 heme-binding site [chemical binding]; other site 745776000348 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 745776000349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 745776000350 DdrB-like protein; Region: DdrB; pfam12747 745776000351 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 745776000352 DNA topoisomerase I, bacterial; Region: topA_bact; TIGR01051 745776000353 active site 745776000354 interdomain interaction site; other site 745776000355 putative metal-binding site [ion binding]; other site 745776000356 nucleotide binding site [chemical binding]; other site 745776000357 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 745776000358 domain I; other site 745776000359 phosphate binding site [ion binding]; other site 745776000360 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 745776000361 domain II; other site 745776000362 domain III; other site 745776000363 nucleotide binding site [chemical binding]; other site 745776000364 DNA binding groove [nucleotide binding] 745776000365 catalytic site [active] 745776000366 domain IV; other site 745776000367 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 745776000368 Family description; Region: UvrD_C_2; pfam13538 745776000369 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 745776000370 DnaA N-terminal domain; Region: DnaA_N; pfam11638 745776000371 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745776000372 Walker A motif; other site 745776000373 ATP binding site [chemical binding]; other site 745776000374 Walker B motif; other site 745776000375 arginine finger; other site 745776000376 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 745776000377 DnaA box-binding interface [nucleotide binding]; other site 745776000378 DNA polymerase III subunit beta; Provisional; Region: PRK14945 745776000379 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 745776000380 putative DNA binding surface [nucleotide binding]; other site 745776000381 dimer interface [polypeptide binding]; other site 745776000382 beta-clamp/clamp loader binding surface; other site 745776000383 beta-clamp/translesion DNA polymerase binding surface; other site 745776000384 enolase; Provisional; Region: eno; PRK00077 745776000385 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 745776000386 dimer interface [polypeptide binding]; other site 745776000387 metal binding site [ion binding]; metal-binding site 745776000388 substrate binding pocket [chemical binding]; other site 745776000389 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 745776000390 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 745776000391 domain interfaces; other site 745776000392 active site 745776000393 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 745776000394 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 745776000395 Cl binding site [ion binding]; other site 745776000396 oligomer interface [polypeptide binding]; other site 745776000397 oxidoreductase; Provisional; Region: PRK06196 745776000398 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 745776000399 putative NAD(P) binding site [chemical binding]; other site 745776000400 active site 745776000401 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 745776000402 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 745776000403 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 745776000404 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 745776000405 NAD(P) binding site [chemical binding]; other site 745776000406 LDH/MDH dimer interface [polypeptide binding]; other site 745776000407 substrate binding site [chemical binding]; other site 745776000408 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 745776000409 Ligand Binding Site [chemical binding]; other site 745776000410 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 745776000411 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 745776000412 Beta-Casp domain; Region: Beta-Casp; smart01027 745776000413 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 745776000414 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 745776000415 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745776000416 membrane-bound complex binding site; other site 745776000417 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 745776000418 putative active site [active] 745776000419 oxidoreductase; Provisional; Region: PRK06128 745776000420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745776000421 NAD(P) binding site [chemical binding]; other site 745776000422 active site 745776000423 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 745776000424 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 745776000425 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 745776000426 active site 745776000427 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 745776000428 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 745776000429 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 745776000430 ligand binding site [chemical binding]; other site 745776000431 flexible hinge region; other site 745776000432 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 745776000433 putative switch regulator; other site 745776000434 non-specific DNA interactions [nucleotide binding]; other site 745776000435 DNA binding site [nucleotide binding] 745776000436 sequence specific DNA binding site [nucleotide binding]; other site 745776000437 putative cAMP binding site [chemical binding]; other site 745776000438 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 745776000439 Coenzyme A binding pocket [chemical binding]; other site 745776000440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3877 745776000441 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 745776000442 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 745776000443 RNB domain; Region: RNB; pfam00773 745776000444 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 745776000445 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 745776000446 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 745776000447 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 745776000448 Coenzyme A binding pocket [chemical binding]; other site 745776000449 Thioredoxin; Region: Thioredoxin_5; pfam13743 745776000450 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 745776000451 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745776000452 non-specific DNA binding site [nucleotide binding]; other site 745776000453 salt bridge; other site 745776000454 sequence-specific DNA binding site [nucleotide binding]; other site 745776000455 PBP superfamily domain; Region: PBP_like; pfam12727 745776000456 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 745776000457 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 745776000458 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 745776000459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776000460 dimer interface [polypeptide binding]; other site 745776000461 conserved gate region; other site 745776000462 putative PBP binding loops; other site 745776000463 ABC-ATPase subunit interface; other site 745776000464 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 745776000465 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 745776000466 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745776000467 catalytic residue [active] 745776000468 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 745776000469 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 745776000470 putative active site; other site 745776000471 catalytic triad [active] 745776000472 putative dimer interface [polypeptide binding]; other site 745776000473 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 745776000474 binding surface 745776000475 TPR motif; other site 745776000476 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 745776000477 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 745776000478 active site 745776000479 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 745776000480 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 745776000481 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 745776000482 FeoA domain; Region: FeoA; pfam04023 745776000483 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 745776000484 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 745776000485 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 745776000486 DNA binding residues [nucleotide binding] 745776000487 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 745776000488 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 745776000489 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 745776000490 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 745776000491 minor groove reading motif; other site 745776000492 helix-hairpin-helix signature motif; other site 745776000493 active site 745776000494 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 745776000495 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 745776000496 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 745776000497 substrate binding site [chemical binding]; other site 745776000498 putative active site [active] 745776000499 putative cosubstrate binding site; other site 745776000500 catalytic site [active] 745776000501 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 745776000502 substrate binding site [chemical binding]; other site 745776000503 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 745776000504 active site 745776000505 catalytic residues [active] 745776000506 metal binding site [ion binding]; metal-binding site 745776000507 Predicted amidohydrolase [General function prediction only]; Region: COG0388 745776000508 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 745776000509 putative active site [active] 745776000510 catalytic triad [active] 745776000511 putative dimer interface [polypeptide binding]; other site 745776000512 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 745776000513 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745776000514 Coenzyme A binding pocket [chemical binding]; other site 745776000515 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 745776000516 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 745776000517 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 745776000518 active site 745776000519 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 745776000520 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 745776000521 active site 745776000522 OstA-like protein; Region: OstA; cl00844 745776000523 OstA-like protein; Region: OstA; cl00844 745776000524 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 745776000525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745776000526 S-adenosylmethionine binding site [chemical binding]; other site 745776000527 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 745776000528 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 745776000529 substrate-cofactor binding pocket; other site 745776000530 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745776000531 catalytic residue [active] 745776000532 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 745776000533 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 745776000534 propionate/acetate kinase; Provisional; Region: PRK12379 745776000535 phosphate acetyltransferase; Reviewed; Region: PRK05632 745776000536 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 745776000537 DRTGG domain; Region: DRTGG; pfam07085 745776000538 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 745776000539 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 745776000540 putative dimer interface [polypeptide binding]; other site 745776000541 catalytic triad [active] 745776000542 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 745776000543 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 745776000544 active site 745776000545 metal binding site [ion binding]; metal-binding site 745776000546 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases [Signal transduction mechanisms]; Region: ApaH; COG0639 745776000547 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 745776000548 DNA polymerase III subunit delta'; Validated; Region: PRK08485 745776000549 Predicted permeases [General function prediction only]; Region: COG0795 745776000550 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 745776000551 Predicted permeases [General function prediction only]; Region: COG0795 745776000552 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 745776000553 fumarate hydratase; Reviewed; Region: fumC; PRK00485 745776000554 Class II fumarases; Region: Fumarase_classII; cd01362 745776000555 active site 745776000556 tetramer interface [polypeptide binding]; other site 745776000557 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 745776000558 putative DNA binding site [nucleotide binding]; other site 745776000559 putative Zn2+ binding site [ion binding]; other site 745776000560 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 745776000561 hydrophobic ligand binding site; other site 745776000562 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 745776000563 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745776000564 Major Facilitator Superfamily; Region: MFS_1; pfam07690 745776000565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745776000566 putative substrate translocation pore; other site 745776000567 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 745776000568 FMN binding site [chemical binding]; other site 745776000569 substrate binding site [chemical binding]; other site 745776000570 putative catalytic residue [active] 745776000571 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 745776000572 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 745776000573 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 745776000574 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 745776000575 VanW like protein; Region: VanW; pfam04294 745776000576 G5 domain; Region: G5; pfam07501 745776000577 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 745776000578 ParB-like nuclease domain; Region: ParB; smart00470 745776000579 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 745776000580 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 745776000581 P-loop; other site 745776000582 Magnesium ion binding site [ion binding]; other site 745776000583 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 745776000584 Magnesium ion binding site [ion binding]; other site 745776000585 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 745776000586 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 745776000587 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 745776000588 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 745776000589 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 745776000590 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 745776000591 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 745776000592 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 745776000593 TPP-binding site [chemical binding]; other site 745776000594 tetramer interface [polypeptide binding]; other site 745776000595 heterodimer interface [polypeptide binding]; other site 745776000596 phosphorylation loop region [posttranslational modification] 745776000597 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 745776000598 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 745776000599 alpha subunit interface [polypeptide binding]; other site 745776000600 TPP binding site [chemical binding]; other site 745776000601 heterodimer interface [polypeptide binding]; other site 745776000602 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 745776000603 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 745776000604 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 745776000605 E3 interaction surface; other site 745776000606 lipoyl attachment site [posttranslational modification]; other site 745776000607 e3 binding domain; Region: E3_binding; pfam02817 745776000608 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 745776000609 Membrane transport protein; Region: Mem_trans; cl09117 745776000610 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 745776000611 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 745776000612 oligomer interface [polypeptide binding]; other site 745776000613 metal binding site [ion binding]; metal-binding site 745776000614 metal binding site [ion binding]; metal-binding site 745776000615 putative Cl binding site [ion binding]; other site 745776000616 aspartate ring; other site 745776000617 basic sphincter; other site 745776000618 hydrophobic gate; other site 745776000619 periplasmic entrance; other site 745776000620 CrcB-like protein; Region: CRCB; cl09114 745776000621 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 745776000622 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 745776000623 generic binding surface II; other site 745776000624 generic binding surface I; other site 745776000625 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 745776000626 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 745776000627 active site residue [active] 745776000628 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 745776000629 active site residue [active] 745776000630 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 745776000631 Predicted periplasmic protein [Function unknown]; Region: COG3698 745776000632 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 745776000633 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 745776000634 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 745776000635 XdhC Rossmann domain; Region: XdhC_C; pfam13478 745776000636 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 745776000637 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 745776000638 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 745776000639 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 745776000640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776000641 active site 745776000642 phosphorylation site [posttranslational modification] 745776000643 intermolecular recognition site; other site 745776000644 dimerization interface [polypeptide binding]; other site 745776000645 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 745776000646 DNA binding site [nucleotide binding] 745776000647 Response regulator receiver domain; Region: Response_reg; pfam00072 745776000648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776000649 active site 745776000650 phosphorylation site [posttranslational modification] 745776000651 intermolecular recognition site; other site 745776000652 dimerization interface [polypeptide binding]; other site 745776000653 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 745776000654 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745776000655 active site 745776000656 motif I; other site 745776000657 motif II; other site 745776000658 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745776000659 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK14662 745776000660 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 745776000661 active site 745776000662 NTP binding site [chemical binding]; other site 745776000663 metal binding triad [ion binding]; metal-binding site 745776000664 antibiotic binding site [chemical binding]; other site 745776000665 Uncharacterized conserved protein [Function unknown]; Region: COG2361 745776000666 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 745776000667 active site 745776000668 catalytic tetrad [active] 745776000669 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 745776000670 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 745776000671 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 745776000672 TM-ABC transporter signature motif; other site 745776000673 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 745776000674 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 745776000675 TM-ABC transporter signature motif; other site 745776000676 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 745776000677 Domain of unknown function DUF20; Region: UPF0118; pfam01594 745776000678 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 745776000679 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 745776000680 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 745776000681 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 745776000682 putative [4Fe-4S] binding site [ion binding]; other site 745776000683 putative molybdopterin cofactor binding site [chemical binding]; other site 745776000684 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 745776000685 putative molybdopterin cofactor binding site; other site 745776000686 Bacterial sugar transferase; Region: Bac_transf; pfam02397 745776000687 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 745776000688 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 745776000689 TPP-binding site [chemical binding]; other site 745776000690 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 745776000691 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 745776000692 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 745776000693 E3 interaction surface; other site 745776000694 lipoyl attachment site [posttranslational modification]; other site 745776000695 e3 binding domain; Region: E3_binding; pfam02817 745776000696 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 745776000697 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 745776000698 nucleotide binding site [chemical binding]; other site 745776000699 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 745776000700 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776000701 Walker A/P-loop; other site 745776000702 ATP binding site [chemical binding]; other site 745776000703 Q-loop/lid; other site 745776000704 ABC transporter signature motif; other site 745776000705 Walker B; other site 745776000706 D-loop; other site 745776000707 H-loop/switch region; other site 745776000708 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 745776000709 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 745776000710 TM-ABC transporter signature motif; other site 745776000711 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 745776000712 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 745776000713 ligand binding site [chemical binding]; other site 745776000714 Transcriptional regulators [Transcription]; Region: PurR; COG1609 745776000715 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745776000716 DNA binding site [nucleotide binding] 745776000717 domain linker motif; other site 745776000718 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 745776000719 dimerization interface [polypeptide binding]; other site 745776000720 ligand binding site [chemical binding]; other site 745776000721 Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Region: RpsF; COG0360 745776000722 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 745776000723 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 745776000724 dimer interface [polypeptide binding]; other site 745776000725 ssDNA binding site [nucleotide binding]; other site 745776000726 tetramer (dimer of dimers) interface [polypeptide binding]; other site 745776000727 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 745776000728 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 745776000729 dimer interface [polypeptide binding]; other site 745776000730 ssDNA binding site [nucleotide binding]; other site 745776000731 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 745776000732 tetramer (dimer of dimers) interface [polypeptide binding]; other site 745776000733 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 745776000734 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 745776000735 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 745776000736 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 745776000737 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 745776000738 Predicted integral membrane protein [Function unknown]; Region: COG5530 745776000739 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 745776000740 CoenzymeA binding site [chemical binding]; other site 745776000741 subunit interaction site [polypeptide binding]; other site 745776000742 PHB binding site; other site 745776000743 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 745776000744 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 745776000745 active site 745776000746 metal binding site [ion binding]; metal-binding site 745776000747 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 745776000748 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 745776000749 active site 745776000750 KMSKS motif; other site 745776000751 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 745776000752 nudix motif; other site 745776000753 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 745776000754 active site 745776000755 dimer interfaces [polypeptide binding]; other site 745776000756 catalytic residues [active] 745776000757 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 745776000758 active site 745776000759 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 745776000760 homotrimer interaction site [polypeptide binding]; other site 745776000761 putative active site [active] 745776000762 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 745776000763 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 745776000764 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 745776000765 RNase E interface [polypeptide binding]; other site 745776000766 trimer interface [polypeptide binding]; other site 745776000767 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 745776000768 RNase E interface [polypeptide binding]; other site 745776000769 trimer interface [polypeptide binding]; other site 745776000770 active site 745776000771 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 745776000772 putative nucleic acid binding region [nucleotide binding]; other site 745776000773 G-X-X-G motif; other site 745776000774 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 745776000775 RNA binding site [nucleotide binding]; other site 745776000776 domain interface; other site 745776000777 DinB family; Region: DinB; cl17821 745776000778 DinB superfamily; Region: DinB_2; pfam12867 745776000779 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 745776000780 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 745776000781 FMN binding site [chemical binding]; other site 745776000782 active site 745776000783 catalytic residues [active] 745776000784 substrate binding site [chemical binding]; other site 745776000785 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 745776000786 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 745776000787 nucleotide binding site [chemical binding]; other site 745776000788 N-acetyl-L-glutamate binding site [chemical binding]; other site 745776000789 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 745776000790 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 745776000791 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 745776000792 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 745776000793 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 745776000794 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745776000795 motif II; other site 745776000796 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 745776000797 classical (c) SDRs; Region: SDR_c; cd05233 745776000798 NAD(P) binding site [chemical binding]; other site 745776000799 active site 745776000800 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 745776000801 Metallopeptidase family M24; Region: Peptidase_M24; pfam00557 745776000802 active site 745776000803 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 745776000804 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 745776000805 active site 745776000806 catalytic site [active] 745776000807 metal binding site [ion binding]; metal-binding site 745776000808 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 745776000809 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 745776000810 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 745776000811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776000812 putative PBP binding loops; other site 745776000813 ABC-ATPase subunit interface; other site 745776000814 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 745776000815 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776000816 dimer interface [polypeptide binding]; other site 745776000817 conserved gate region; other site 745776000818 putative PBP binding loops; other site 745776000819 ABC-ATPase subunit interface; other site 745776000820 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 745776000821 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 745776000822 putative active site [active] 745776000823 catalytic site [active] 745776000824 putative metal binding site [ion binding]; other site 745776000825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 745776000826 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 745776000827 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 745776000828 active site 745776000829 Zn binding site [ion binding]; other site 745776000830 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 745776000831 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 745776000832 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 745776000833 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 745776000834 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 745776000835 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 745776000836 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 745776000837 catalytic motif [active] 745776000838 Zn binding site [ion binding]; other site 745776000839 RibD C-terminal domain; Region: RibD_C; cl17279 745776000840 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 745776000841 Lumazine binding domain; Region: Lum_binding; pfam00677 745776000842 Lumazine binding domain; Region: Lum_binding; pfam00677 745776000843 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 745776000844 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 745776000845 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 745776000846 dimerization interface [polypeptide binding]; other site 745776000847 active site 745776000848 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 745776000849 homopentamer interface [polypeptide binding]; other site 745776000850 active site 745776000851 Predicted type IV restriction endonuclease [Defense mechanisms]; Region: COG2810 745776000852 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 745776000853 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 745776000854 Fe-S oxidoreductase, related to NifB/MoaA family [Energy production and conversion]; Region: COG1625 745776000855 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 745776000856 Protein of unknown function (DUF512); Region: DUF512; pfam04459 745776000857 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 745776000858 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745776000859 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 745776000860 dimerization interface [polypeptide binding]; other site 745776000861 substrate binding pocket [chemical binding]; other site 745776000862 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 745776000863 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745776000864 Coenzyme A binding pocket [chemical binding]; other site 745776000865 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 745776000866 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 745776000867 substrate binding site [chemical binding]; other site 745776000868 oxyanion hole (OAH) forming residues; other site 745776000869 trimer interface [polypeptide binding]; other site 745776000870 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 745776000871 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745776000872 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745776000873 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 745776000874 dimerization interface [polypeptide binding]; other site 745776000875 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 745776000876 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 745776000877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 745776000878 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 745776000879 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776000880 Walker A/P-loop; other site 745776000881 ATP binding site [chemical binding]; other site 745776000882 Q-loop/lid; other site 745776000883 ABC transporter signature motif; other site 745776000884 Walker B; other site 745776000885 D-loop; other site 745776000886 H-loop/switch region; other site 745776000887 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 745776000888 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 745776000889 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 745776000890 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 745776000891 dimerization interface [polypeptide binding]; other site 745776000892 metal binding site [ion binding]; metal-binding site 745776000893 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 745776000894 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 745776000895 Substrate-binding site [chemical binding]; other site 745776000896 Substrate specificity [chemical binding]; other site 745776000897 AAA domain; Region: AAA_33; pfam13671 745776000898 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 745776000899 Substrate-binding site [chemical binding]; other site 745776000900 Substrate specificity [chemical binding]; other site 745776000901 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 745776000902 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 745776000903 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 745776000904 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 745776000905 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 745776000906 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 745776000907 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 745776000908 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 745776000909 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 745776000910 glutaminase active site [active] 745776000911 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 745776000912 dimer interface [polypeptide binding]; other site 745776000913 active site 745776000914 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 745776000915 dimer interface [polypeptide binding]; other site 745776000916 active site 745776000917 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 745776000918 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 745776000919 active site 745776000920 dimer interface [polypeptide binding]; other site 745776000921 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 745776000922 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 745776000923 active site 745776000924 FMN binding site [chemical binding]; other site 745776000925 substrate binding site [chemical binding]; other site 745776000926 3Fe-4S cluster binding site [ion binding]; other site 745776000927 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 745776000928 domain interface; other site 745776000929 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 745776000930 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 745776000931 GAF domain; Region: GAF; cl17456 745776000932 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 745776000933 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 745776000934 Zn2+ binding site [ion binding]; other site 745776000935 Mg2+ binding site [ion binding]; other site 745776000936 Predicted integral membrane protein [Function unknown]; Region: COG5637 745776000937 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 745776000938 putative hydrophobic ligand binding site [chemical binding]; other site 745776000939 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 745776000940 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 745776000941 substrate binding site [chemical binding]; other site 745776000942 dimer interface [polypeptide binding]; other site 745776000943 NADP binding site [chemical binding]; other site 745776000944 catalytic residues [active] 745776000945 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 745776000946 substrate binding site [chemical binding]; other site 745776000947 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 745776000948 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 745776000949 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745776000950 metal binding site [ion binding]; metal-binding site 745776000951 active site 745776000952 I-site; other site 745776000953 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 745776000954 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 745776000955 catalytic core [active] 745776000956 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 745776000957 Domain of unknown function (DUF427); Region: DUF427; pfam04248 745776000958 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 745776000959 putative active site [active] 745776000960 catalytic residue [active] 745776000961 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 745776000962 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 745776000963 oligomer interface [polypeptide binding]; other site 745776000964 active site 745776000965 metal binding site [ion binding]; metal-binding site 745776000966 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 745776000967 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 745776000968 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 745776000969 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 745776000970 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 745776000971 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 745776000972 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 745776000973 FeS/SAM binding site; other site 745776000974 HemN C-terminal domain; Region: HemN_C; pfam06969 745776000975 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 745776000976 CoenzymeA binding site [chemical binding]; other site 745776000977 subunit interaction site [polypeptide binding]; other site 745776000978 PHB binding site; other site 745776000979 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 745776000980 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 745776000981 active site 745776000982 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 745776000983 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 745776000984 CMP-binding site; other site 745776000985 The sites determining sugar specificity; other site 745776000986 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 745776000987 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 745776000988 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 745776000989 generic binding surface I; other site 745776000990 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 745776000991 putative active site [active] 745776000992 putative catalytic site [active] 745776000993 putative Mg binding site IVb [ion binding]; other site 745776000994 putative phosphate binding site [ion binding]; other site 745776000995 putative DNA binding site [nucleotide binding]; other site 745776000996 putative Mg binding site IVa [ion binding]; other site 745776000997 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 745776000998 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745776000999 Coenzyme A binding pocket [chemical binding]; other site 745776001000 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 745776001001 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745776001002 Coenzyme A binding pocket [chemical binding]; other site 745776001003 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 745776001004 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 745776001005 substrate binding site [chemical binding]; other site 745776001006 activation loop (A-loop); other site 745776001007 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 745776001008 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 745776001009 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 745776001010 Transcriptional regulator [Transcription]; Region: IclR; COG1414 745776001011 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 745776001012 Bacterial transcriptional regulator; Region: IclR; pfam01614 745776001013 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 745776001014 Dynamin family; Region: Dynamin_N; pfam00350 745776001015 G1 box; other site 745776001016 GTP/Mg2+ binding site [chemical binding]; other site 745776001017 G2 box; other site 745776001018 Switch I region; other site 745776001019 G3 box; other site 745776001020 Switch II region; other site 745776001021 G4 box; other site 745776001022 G5 box; other site 745776001023 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 745776001024 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 745776001025 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 745776001026 Thymidine phosphorylase [Nucleotide transport and metabolism]; Region: DeoA; COG0213 745776001027 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 745776001028 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 745776001029 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 745776001030 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 745776001031 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 745776001032 catalytic residue [active] 745776001033 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 745776001034 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 745776001035 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 745776001036 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 745776001037 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 745776001038 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 745776001039 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04135 745776001040 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 745776001041 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 745776001042 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745776001043 DNA-binding site [nucleotide binding]; DNA binding site 745776001044 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 745776001045 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745776001046 homodimer interface [polypeptide binding]; other site 745776001047 catalytic residue [active] 745776001048 Benzoate membrane transport protein; Region: BenE; pfam03594 745776001049 benzoate transporter; Region: benE; TIGR00843 745776001050 acyl-CoA synthetase; Validated; Region: PRK08162 745776001051 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 745776001052 acyl-activating enzyme (AAE) consensus motif; other site 745776001053 putative active site [active] 745776001054 AMP binding site [chemical binding]; other site 745776001055 putative CoA binding site [chemical binding]; other site 745776001056 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 745776001057 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 745776001058 nudix motif; other site 745776001059 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 745776001060 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 745776001061 active site 745776001062 HIGH motif; other site 745776001063 nucleotide binding site [chemical binding]; other site 745776001064 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 745776001065 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 745776001066 active site 745776001067 KMSKS motif; other site 745776001068 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 745776001069 tRNA binding surface [nucleotide binding]; other site 745776001070 anticodon binding site; other site 745776001071 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 745776001072 acetyl-CoA synthetase; Provisional; Region: PRK00174 745776001073 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 745776001074 active site 745776001075 CoA binding site [chemical binding]; other site 745776001076 acyl-activating enzyme (AAE) consensus motif; other site 745776001077 AMP binding site [chemical binding]; other site 745776001078 acetate binding site [chemical binding]; other site 745776001079 Response regulator receiver domain; Region: Response_reg; pfam00072 745776001080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776001081 active site 745776001082 phosphorylation site [posttranslational modification] 745776001083 intermolecular recognition site; other site 745776001084 dimerization interface [polypeptide binding]; other site 745776001085 succinyldiaminopimelate transaminase; Validated; Region: PRK07366 745776001086 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 745776001087 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745776001088 homodimer interface [polypeptide binding]; other site 745776001089 catalytic residue [active] 745776001090 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 745776001091 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 745776001092 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 745776001093 dimerization interface [polypeptide binding]; other site 745776001094 DPS ferroxidase diiron center [ion binding]; other site 745776001095 ion pore; other site 745776001096 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 745776001097 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 745776001098 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 745776001099 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 745776001100 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 745776001101 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 745776001102 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 745776001103 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 745776001104 Walker A/P-loop; other site 745776001105 ATP binding site [chemical binding]; other site 745776001106 Q-loop/lid; other site 745776001107 ABC transporter signature motif; other site 745776001108 Walker B; other site 745776001109 D-loop; other site 745776001110 H-loop/switch region; other site 745776001111 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 745776001112 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 745776001113 Walker A/P-loop; other site 745776001114 ATP binding site [chemical binding]; other site 745776001115 Q-loop/lid; other site 745776001116 ABC transporter signature motif; other site 745776001117 Walker B; other site 745776001118 D-loop; other site 745776001119 H-loop/switch region; other site 745776001120 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 745776001121 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 745776001122 TM-ABC transporter signature motif; other site 745776001123 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 745776001124 TM-ABC transporter signature motif; other site 745776001125 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 745776001126 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_13; cd06348 745776001127 putative ligand binding site [chemical binding]; other site 745776001128 PAS fold; Region: PAS_4; pfam08448 745776001129 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 745776001130 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745776001131 metal binding site [ion binding]; metal-binding site 745776001132 active site 745776001133 I-site; other site 745776001134 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 745776001135 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 745776001136 DNA polymerase IV (family X) [DNA replication, recombination, and repair]; Region: POL4; COG1796 745776001137 metal binding triad [ion binding]; metal-binding site 745776001138 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 745776001139 Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387 745776001140 active site 745776001141 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 745776001142 active site 745776001143 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 745776001144 EamA-like transporter family; Region: EamA; pfam00892 745776001145 ornithine carbamoyltransferase; Provisional; Region: PRK00779 745776001146 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 745776001147 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 745776001148 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 745776001149 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 745776001150 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 745776001151 nudix motif; other site 745776001152 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 745776001153 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 745776001154 Archaeal/vacuolar-type H+-ATPase subunit I [Energy production and conversion]; Region: NtpI; COG1269 745776001155 ATP synthase subunit C; Region: ATP-synt_C; cl00466 745776001156 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 745776001157 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 745776001158 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 745776001159 Archaeal/vacuolar-type H+-ATPase subunit F [Energy production and conversion]; Region: NtpG; COG1436 745776001160 V-type ATP synthase subunit A; Provisional; Region: PRK04192 745776001161 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 745776001162 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 745776001163 Walker A motif/ATP binding site; other site 745776001164 Walker B motif; other site 745776001165 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 745776001166 V-type ATP synthase subunit B; Provisional; Region: PRK04196 745776001167 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 745776001168 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 745776001169 Walker A motif homologous position; other site 745776001170 Walker B motif; other site 745776001171 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 745776001172 Archaeal/vacuolar-type H+-ATPase subunit D [Energy production and conversion]; Region: NtpD; COG1394 745776001173 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 745776001174 Protease prsW family; Region: PrsW-protease; pfam13367 745776001175 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 745776001176 active site 745776001177 putative DNA-binding cleft [nucleotide binding]; other site 745776001178 dimer interface [polypeptide binding]; other site 745776001179 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 745776001180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776001181 dimer interface [polypeptide binding]; other site 745776001182 conserved gate region; other site 745776001183 putative PBP binding loops; other site 745776001184 ABC-ATPase subunit interface; other site 745776001185 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 745776001186 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776001187 dimer interface [polypeptide binding]; other site 745776001188 conserved gate region; other site 745776001189 putative PBP binding loops; other site 745776001190 ABC-ATPase subunit interface; other site 745776001191 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 745776001192 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 745776001193 peptide binding site [polypeptide binding]; other site 745776001194 dimer interface [polypeptide binding]; other site 745776001195 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 745776001196 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 745776001197 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 745776001198 heme bH binding site [chemical binding]; other site 745776001199 intrachain domain interface; other site 745776001200 heme bL binding site [chemical binding]; other site 745776001201 interchain domain interface [polypeptide binding]; other site 745776001202 Qo binding site; other site 745776001203 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 745776001204 intrachain domain interface; other site 745776001205 Qo binding site; other site 745776001206 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 745776001207 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 745776001208 iron-sulfur cluster [ion binding]; other site 745776001209 [2Fe-2S] cluster binding site [ion binding]; other site 745776001210 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 745776001211 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 745776001212 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 745776001213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776001214 active site 745776001215 phosphorylation site [posttranslational modification] 745776001216 intermolecular recognition site; other site 745776001217 dimerization interface [polypeptide binding]; other site 745776001218 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 745776001219 DNA binding residues [nucleotide binding] 745776001220 dimerization interface [polypeptide binding]; other site 745776001221 S-layer homology domain; Region: SLH; pfam00395 745776001222 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 745776001223 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 745776001224 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 745776001225 DHHA2 domain; Region: DHHA2; pfam02833 745776001226 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 745776001227 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 745776001228 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745776001229 sequence-specific DNA binding site [nucleotide binding]; other site 745776001230 salt bridge; other site 745776001231 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 745776001232 trimer interface [polypeptide binding]; other site 745776001233 dimer interface [polypeptide binding]; other site 745776001234 putative active site [active] 745776001235 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 745776001236 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 745776001237 catalytic triad [active] 745776001238 GTP-binding protein Der; Reviewed; Region: PRK00093 745776001239 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 745776001240 G1 box; other site 745776001241 GTP/Mg2+ binding site [chemical binding]; other site 745776001242 Switch I region; other site 745776001243 G2 box; other site 745776001244 Switch II region; other site 745776001245 G3 box; other site 745776001246 G4 box; other site 745776001247 G5 box; other site 745776001248 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 745776001249 G1 box; other site 745776001250 GTP/Mg2+ binding site [chemical binding]; other site 745776001251 Switch I region; other site 745776001252 G2 box; other site 745776001253 G3 box; other site 745776001254 Switch II region; other site 745776001255 G4 box; other site 745776001256 G5 box; other site 745776001257 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 745776001258 Beta-lactamase; Region: Beta-lactamase; pfam00144 745776001259 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 745776001260 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 745776001261 motif 1; other site 745776001262 active site 745776001263 motif 2; other site 745776001264 motif 3; other site 745776001265 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 745776001266 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 745776001267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776001268 active site 745776001269 phosphorylation site [posttranslational modification] 745776001270 intermolecular recognition site; other site 745776001271 dimerization interface [polypeptide binding]; other site 745776001272 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 745776001273 Amidohydrolase family; Region: Amidohydro_3; pfam07969 745776001274 active site 745776001275 hypothetical protein; Validated; Region: PRK00110 745776001276 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 745776001277 Ubiquitin-like proteins; Region: UBQ; cl00155 745776001278 charged pocket; other site 745776001279 hydrophobic patch; other site 745776001280 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 745776001281 dimerization interface [polypeptide binding]; other site 745776001282 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 745776001283 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 745776001284 substrate binding site [chemical binding]; other site 745776001285 ATP binding site [chemical binding]; other site 745776001286 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 745776001287 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 745776001288 GatB domain; Region: GatB_Yqey; smart00845 745776001289 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 745776001290 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 745776001291 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 745776001292 active site 745776001293 oligomerization interface [polypeptide binding]; other site 745776001294 metal binding site [ion binding]; metal-binding site 745776001295 Protein of unknown function (DUF420); Region: DUF420; cl00989 745776001296 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 745776001297 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 745776001298 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 745776001299 UbiA prenyltransferase family; Region: UbiA; pfam01040 745776001300 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 745776001301 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 745776001302 Cytochrome c; Region: Cytochrom_C; pfam00034 745776001303 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 745776001304 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 745776001305 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 745776001306 Subunit I/III interface [polypeptide binding]; other site 745776001307 Methyltransferase domain; Region: Methyltransf_23; pfam13489 745776001308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745776001309 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 745776001310 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 745776001311 Methyltransferase domain; Region: Methyltransf_23; pfam13489 745776001312 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745776001313 S-adenosylmethionine binding site [chemical binding]; other site 745776001314 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; cl01930 745776001315 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 745776001316 NMT1/THI5 like; Region: NMT1; pfam09084 745776001317 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 745776001318 Phosphotransferase enzyme family; Region: APH; pfam01636 745776001319 active site 745776001320 ATP binding site [chemical binding]; other site 745776001321 antibiotic binding site [chemical binding]; other site 745776001322 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 745776001323 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 745776001324 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 745776001325 DdrB-like protein; Region: DdrB; pfam12747 745776001326 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 745776001327 metal binding site [ion binding]; metal-binding site 745776001328 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 745776001329 DNA binding residues [nucleotide binding] 745776001330 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 745776001331 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 745776001332 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 745776001333 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 745776001334 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 745776001335 PAS domain; Region: PAS_8; pfam13188 745776001336 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776001337 ATP binding site [chemical binding]; other site 745776001338 Mg2+ binding site [ion binding]; other site 745776001339 G-X-G motif; other site 745776001340 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 745776001341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776001342 active site 745776001343 phosphorylation site [posttranslational modification] 745776001344 intermolecular recognition site; other site 745776001345 dimerization interface [polypeptide binding]; other site 745776001346 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 745776001347 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 745776001348 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 745776001349 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 745776001350 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 745776001351 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 745776001352 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 745776001353 Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718 745776001354 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 745776001355 ATP binding site [chemical binding]; other site 745776001356 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 745776001357 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 745776001358 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 745776001359 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 745776001360 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 745776001361 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 745776001362 catalytic loop [active] 745776001363 iron binding site [ion binding]; other site 745776001364 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 745776001365 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 745776001366 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 745776001367 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 745776001368 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 745776001369 active site 745776001370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745776001371 Major Facilitator Superfamily; Region: MFS_1; pfam07690 745776001372 putative substrate translocation pore; other site 745776001373 Transcriptional regulators [Transcription]; Region: MarR; COG1846 745776001374 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 745776001375 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 745776001376 putative active site [active] 745776001377 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 745776001378 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 745776001379 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 745776001380 active site 745776001381 NTP binding site [chemical binding]; other site 745776001382 metal binding triad [ion binding]; metal-binding site 745776001383 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 745776001384 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 745776001385 dimer interface [polypeptide binding]; other site 745776001386 acyl-activating enzyme (AAE) consensus motif; other site 745776001387 putative active site [active] 745776001388 AMP binding site [chemical binding]; other site 745776001389 putative CoA binding site [chemical binding]; other site 745776001390 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 745776001391 enoyl-CoA hydratase; Provisional; Region: PRK08140 745776001392 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 745776001393 substrate binding site [chemical binding]; other site 745776001394 oxyanion hole (OAH) forming residues; other site 745776001395 trimer interface [polypeptide binding]; other site 745776001396 DNA primase; Validated; Region: dnaG; PRK05667 745776001397 CHC2 zinc finger; Region: zf-CHC2; cl17510 745776001398 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 745776001399 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 745776001400 interdomain interaction site; other site 745776001401 active site 745776001402 metal binding site [ion binding]; metal-binding site 745776001403 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 745776001404 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 745776001405 catalytic residues [active] 745776001406 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 745776001407 Divergent AAA domain; Region: AAA_4; pfam04326 745776001408 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 745776001409 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 745776001410 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 745776001411 ATP-grasp domain; Region: ATP-grasp_4; cl17255 745776001412 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 745776001413 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 745776001414 ATP-grasp domain; Region: ATP-grasp_4; cl17255 745776001415 aminotransferase; Validated; Region: PRK07777 745776001416 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 745776001417 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745776001418 homodimer interface [polypeptide binding]; other site 745776001419 catalytic residue [active] 745776001420 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 745776001421 ANP binding site [chemical binding]; other site 745776001422 argininosuccinate synthase; Provisional; Region: PRK13820 745776001423 Substrate Binding Site II [chemical binding]; other site 745776001424 Substrate Binding Site I [chemical binding]; other site 745776001425 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 745776001426 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745776001427 Coenzyme A binding pocket [chemical binding]; other site 745776001428 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745776001429 Coenzyme A binding pocket [chemical binding]; other site 745776001430 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 745776001431 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745776001432 Coenzyme A binding pocket [chemical binding]; other site 745776001433 argininosuccinate lyase; Provisional; Region: PRK00855 745776001434 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 745776001435 active sites [active] 745776001436 tetramer interface [polypeptide binding]; other site 745776001437 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 745776001438 nucleotide binding site/active site [active] 745776001439 HIT family signature motif; other site 745776001440 catalytic residue [active] 745776001441 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745776001442 Coenzyme A binding pocket [chemical binding]; other site 745776001443 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745776001444 Coenzyme A binding pocket [chemical binding]; other site 745776001445 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 745776001446 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745776001447 Coenzyme A binding pocket [chemical binding]; other site 745776001448 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 745776001449 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 745776001450 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 745776001451 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 745776001452 catalytic site [active] 745776001453 subunit interface [polypeptide binding]; other site 745776001454 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 745776001455 ligand binding site [chemical binding]; other site 745776001456 active site 745776001457 UGI interface [polypeptide binding]; other site 745776001458 catalytic site [active] 745776001459 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 745776001460 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 745776001461 active site 745776001462 DNA binding site [nucleotide binding] 745776001463 Int/Topo IB signature motif; other site 745776001464 catalytic residues [active] 745776001465 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 745776001466 Nitrogen regulatory protein P-II; Region: P-II; smart00938 745776001467 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 745776001468 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 745776001469 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 745776001470 dimer interface [polypeptide binding]; other site 745776001471 putative functional site; other site 745776001472 putative MPT binding site; other site 745776001473 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 745776001474 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 745776001475 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 745776001476 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 745776001477 Catalytic domain of Protein Kinases; Region: PKc; cd00180 745776001478 active site 745776001479 ATP binding site [chemical binding]; other site 745776001480 substrate binding site [chemical binding]; other site 745776001481 activation loop (A-loop); other site 745776001482 Uncharacterized conserved protein [Function unknown]; Region: COG3391 745776001483 SdiA-regulated; Region: SdiA-regulated; cd09971 745776001484 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 745776001485 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 745776001486 active site 745776001487 multimer interface [polypeptide binding]; other site 745776001488 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745776001489 metal binding site [ion binding]; metal-binding site 745776001490 active site 745776001491 I-site; other site 745776001492 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 745776001493 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 745776001494 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 745776001495 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 745776001496 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 745776001497 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 745776001498 shikimate binding site; other site 745776001499 NAD(P) binding site [chemical binding]; other site 745776001500 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 745776001501 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 745776001502 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 745776001503 inhibitor-cofactor binding pocket; inhibition site 745776001504 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745776001505 catalytic residue [active] 745776001506 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 745776001507 Thiamine pyrophosphokinase; Region: TPK; cd07995 745776001508 active site 745776001509 dimerization interface [polypeptide binding]; other site 745776001510 thiamine binding site [chemical binding]; other site 745776001511 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 745776001512 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 745776001513 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776001514 Walker A/P-loop; other site 745776001515 ATP binding site [chemical binding]; other site 745776001516 Q-loop/lid; other site 745776001517 ABC transporter signature motif; other site 745776001518 Walker B; other site 745776001519 D-loop; other site 745776001520 H-loop/switch region; other site 745776001521 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 745776001522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 745776001523 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 745776001524 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 745776001525 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 745776001526 nudix motif; other site 745776001527 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 745776001528 epoxyqueuosine reductase; Region: TIGR00276 745776001529 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 745776001530 4Fe-4S binding domain; Region: Fer4; cl02805 745776001531 HEAT repeats; Region: HEAT_2; pfam13646 745776001532 SnoaL-like domain; Region: SnoaL_2; pfam12680 745776001533 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 745776001534 active site 745776001535 catalytic residues [active] 745776001536 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 745776001537 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 745776001538 intersubunit interface [polypeptide binding]; other site 745776001539 active site 745776001540 zinc binding site [ion binding]; other site 745776001541 Na+ binding site [ion binding]; other site 745776001542 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 745776001543 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 745776001544 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745776001545 homodimer interface [polypeptide binding]; other site 745776001546 catalytic residue [active] 745776001547 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533 745776001548 homodimer interface [polypeptide binding]; other site 745776001549 metal binding site [ion binding]; metal-binding site 745776001550 glutamate racemase; Provisional; Region: PRK00865 745776001551 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 745776001552 oligomer interface [polypeptide binding]; other site 745776001553 RNA binding site [nucleotide binding]; other site 745776001554 DinB superfamily; Region: DinB_2; pfam12867 745776001555 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 745776001556 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 745776001557 trimer interface [polypeptide binding]; other site 745776001558 active site 745776001559 substrate binding site [chemical binding]; other site 745776001560 CoA binding site [chemical binding]; other site 745776001561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745776001562 S-adenosylmethionine binding site [chemical binding]; other site 745776001563 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 745776001564 putative catalytic site [active] 745776001565 putative metal binding site [ion binding]; other site 745776001566 putative phosphate binding site [ion binding]; other site 745776001567 Exoribonuclease R [Transcription]; Region: VacB; COG0557 745776001568 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 745776001569 RNB domain; Region: RNB; pfam00773 745776001570 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 745776001571 RNA binding site [nucleotide binding]; other site 745776001572 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 745776001573 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 745776001574 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 745776001575 catalytic residue [active] 745776001576 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 745776001577 PASTA domain; Region: PASTA; smart00740 745776001578 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 745776001579 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 745776001580 active site 745776001581 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 745776001582 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 745776001583 prolyl-tRNA synthetase; Provisional; Region: PRK09194 745776001584 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 745776001585 motif 1; other site 745776001586 dimer interface [polypeptide binding]; other site 745776001587 active site 745776001588 motif 2; other site 745776001589 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 745776001590 putative deacylase active site [active] 745776001591 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 745776001592 active site 745776001593 motif 3; other site 745776001594 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 745776001595 anticodon binding site; other site 745776001596 Rhomboid family; Region: Rhomboid; pfam01694 745776001597 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 745776001598 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 745776001599 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 745776001600 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 745776001601 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 745776001602 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 745776001603 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 745776001604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745776001605 putative substrate translocation pore; other site 745776001606 Transcriptional regulators [Transcription]; Region: MarR; COG1846 745776001607 MarR family; Region: MarR_2; pfam12802 745776001608 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 745776001609 hydrophobic ligand binding site; other site 745776001610 Predicted membrane protein [Function unknown]; Region: COG2259 745776001611 MarR family; Region: MarR_2; cl17246 745776001612 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 745776001613 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 745776001614 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 745776001615 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 745776001616 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 745776001617 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 745776001618 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 745776001619 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 745776001620 dimer interface [polypeptide binding]; other site 745776001621 active site 745776001622 KMSKS motif; other site 745776001623 chaperone protein DnaJ; Provisional; Region: PRK14292 745776001624 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 745776001625 HSP70 interaction site [polypeptide binding]; other site 745776001626 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 745776001627 Zn binding sites [ion binding]; other site 745776001628 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 745776001629 dimer interface [polypeptide binding]; other site 745776001630 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 745776001631 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 745776001632 ribose-phosphate pyrophosphokinase; Region: ribP_PPkin; TIGR01251 745776001633 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 745776001634 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 745776001635 active site 745776001636 Protein of unknown function (DUF454); Region: DUF454; cl01063 745776001637 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 745776001638 4Fe-4S binding domain; Region: Fer4; pfam00037 745776001639 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 745776001640 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 745776001641 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 745776001642 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 745776001643 ligand binding site; other site 745776001644 oligomer interface; other site 745776001645 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 745776001646 dimer interface [polypeptide binding]; other site 745776001647 N-terminal domain interface [polypeptide binding]; other site 745776001648 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 745776001649 Family description; Region: UvrD_C_2; pfam13538 745776001650 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 745776001651 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 745776001652 FMN binding site [chemical binding]; other site 745776001653 active site 745776001654 catalytic residues [active] 745776001655 substrate binding site [chemical binding]; other site 745776001656 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 745776001657 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 745776001658 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 745776001659 active site 745776001660 interdomain interaction site; other site 745776001661 putative metal-binding site [ion binding]; other site 745776001662 nucleotide binding site [chemical binding]; other site 745776001663 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 745776001664 domain I; other site 745776001665 phosphate binding site [ion binding]; other site 745776001666 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 745776001667 domain II; other site 745776001668 domain III; other site 745776001669 nucleotide binding site [chemical binding]; other site 745776001670 DNA binding groove [nucleotide binding] 745776001671 catalytic site [active] 745776001672 domain IV; other site 745776001673 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 745776001674 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 745776001675 Cupin domain; Region: Cupin_2; pfam07883 745776001676 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 745776001677 intracellular protease, PfpI family; Region: PfpI; TIGR01382 745776001678 proposed catalytic triad [active] 745776001679 conserved cys residue [active] 745776001680 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745776001681 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 745776001682 NAD(P) binding site [chemical binding]; other site 745776001683 active site 745776001684 glycine dehydrogenase; Provisional; Region: PRK05367 745776001685 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 745776001686 tetramer interface [polypeptide binding]; other site 745776001687 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745776001688 catalytic residue [active] 745776001689 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 745776001690 tetramer interface [polypeptide binding]; other site 745776001691 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745776001692 catalytic residue [active] 745776001693 AAA domain; Region: AAA_18; pfam13238 745776001694 AAA domain; Region: AAA_17; pfam13207 745776001695 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 745776001696 lipoyl attachment site [posttranslational modification]; other site 745776001697 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 745776001698 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 745776001699 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 745776001700 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 745776001701 Tthb094 and related proteins, classical (c) SDRs; Region: Tthb094_like_SDR_c; cd11730 745776001702 NAD(P) binding site [chemical binding]; other site 745776001703 putative active site [active] 745776001704 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 745776001705 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 745776001706 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 745776001707 active site 745776001708 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 745776001709 nudix motif; other site 745776001710 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 745776001711 Peptidase family M1; Region: Peptidase_M1; pfam01433 745776001712 Zn binding site [ion binding]; other site 745776001713 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 745776001714 BON domain; Region: BON; pfam04972 745776001715 BON domain; Region: BON; pfam04972 745776001716 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 745776001717 Predicted transcriptional regulators [Transcription]; Region: COG1695 745776001718 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 745776001719 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 745776001720 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 745776001721 Catalytic site [active] 745776001722 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 745776001723 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 745776001724 Histidine kinase; Region: HisKA_3; pfam07730 745776001725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776001726 ATP binding site [chemical binding]; other site 745776001727 Mg2+ binding site [ion binding]; other site 745776001728 G-X-G motif; other site 745776001729 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 745776001730 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 745776001731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776001732 active site 745776001733 phosphorylation site [posttranslational modification] 745776001734 intermolecular recognition site; other site 745776001735 dimerization interface [polypeptide binding]; other site 745776001736 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 745776001737 DNA binding residues [nucleotide binding] 745776001738 dimerization interface [polypeptide binding]; other site 745776001739 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 745776001740 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 745776001741 tetramer interface [polypeptide binding]; other site 745776001742 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 745776001743 active site 745776001744 Mg2+/Mn2+ binding site [ion binding]; other site 745776001745 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 745776001746 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 745776001747 active site 745776001748 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 745776001749 catalytic tetrad [active] 745776001750 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 745776001751 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 745776001752 active site 745776001753 metal binding site [ion binding]; metal-binding site 745776001754 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 745776001755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776001756 ATP binding site [chemical binding]; other site 745776001757 Mg2+ binding site [ion binding]; other site 745776001758 G-X-G motif; other site 745776001759 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 745776001760 ATP binding site [chemical binding]; other site 745776001761 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 745776001762 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 745776001763 TIGR02588 family protein; Region: TIGR02588 745776001764 Putative integral membrane protein (DUF2391); Region: DUF2391; cl01935 745776001765 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 745776001766 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 745776001767 HIGH motif; other site 745776001768 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 745776001769 active site 745776001770 KMSKS motif; other site 745776001771 septum site-determining protein MinD; Region: minD_bact; TIGR01968 745776001772 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 745776001773 Switch I; other site 745776001774 Switch II; other site 745776001775 cell division topological specificity factor MinE; Region: minE; TIGR01215 745776001776 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 745776001777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776001778 active site 745776001779 phosphorylation site [posttranslational modification] 745776001780 intermolecular recognition site; other site 745776001781 dimerization interface [polypeptide binding]; other site 745776001782 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 745776001783 DNA binding residues [nucleotide binding] 745776001784 dimerization interface [polypeptide binding]; other site 745776001785 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 745776001786 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 745776001787 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745776001788 dimer interface [polypeptide binding]; other site 745776001789 phosphorylation site [posttranslational modification] 745776001790 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776001791 ATP binding site [chemical binding]; other site 745776001792 Mg2+ binding site [ion binding]; other site 745776001793 G-X-G motif; other site 745776001794 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 745776001795 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 745776001796 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 745776001797 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 745776001798 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 745776001799 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 745776001800 active site 745776001801 catalytic site [active] 745776001802 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 745776001803 Domain of unknown function (DUF427); Region: DUF427; pfam04248 745776001804 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 745776001805 aromatic arch; other site 745776001806 DCoH dimer interaction site [polypeptide binding]; other site 745776001807 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 745776001808 DCoH tetramer interaction site [polypeptide binding]; other site 745776001809 substrate binding site [chemical binding]; other site 745776001810 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 745776001811 active site 745776001812 monovalent cation/proton antiporter, MnhG/PhaG subunit; Region: CPA3_mnhG_phaG; TIGR01300 745776001813 Multisubunit Na+/H+ antiporter, MnhF subunit [Inorganic ion transport and metabolism]; Region: MnhF; COG2212 745776001814 Multisubunit Na+/H+ antiporter, MnhE subunit [Inorganic ion transport and metabolism]; Region: MnhE; COG1863 745776001815 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 745776001816 Multicomponent Na+:H+ antiporter, MnhC subunit; Region: 2a6301s03; TIGR00941 745776001817 monovalent cation:proton antiporter; Region: 2a6301s02; TIGR00943 745776001818 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 745776001819 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 745776001820 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 745776001821 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 745776001822 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 745776001823 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 745776001824 UV-endonuclease UvdE; Region: UvdE; cl10036 745776001825 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 745776001826 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 745776001827 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 745776001828 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 745776001829 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 745776001830 DNA binding residues [nucleotide binding] 745776001831 drug binding residues [chemical binding]; other site 745776001832 dimer interface [polypeptide binding]; other site 745776001833 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 745776001834 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745776001835 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 745776001836 dimerization interface [polypeptide binding]; other site 745776001837 substrate binding pocket [chemical binding]; other site 745776001838 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 745776001839 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 745776001840 dimer interface [polypeptide binding]; other site 745776001841 TPP-binding site [chemical binding]; other site 745776001842 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 745776001843 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 745776001844 E3 interaction surface; other site 745776001845 lipoyl attachment site [posttranslational modification]; other site 745776001846 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 745776001847 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 745776001848 E3 interaction surface; other site 745776001849 lipoyl attachment site [posttranslational modification]; other site 745776001850 e3 binding domain; Region: E3_binding; pfam02817 745776001851 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 745776001852 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 745776001853 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 745776001854 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 745776001855 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 745776001856 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 745776001857 active site 745776001858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745776001859 Major Facilitator Superfamily; Region: MFS_1; pfam07690 745776001860 putative substrate translocation pore; other site 745776001861 membrane protein; Provisional; Region: PRK14401 745776001862 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 745776001863 ATP binding site [chemical binding]; other site 745776001864 substrate interface [chemical binding]; other site 745776001865 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 745776001866 IHF - DNA interface [nucleotide binding]; other site 745776001867 IHF dimer interface [polypeptide binding]; other site 745776001868 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 745776001869 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 745776001870 Transcriptional regulators [Transcription]; Region: PurR; COG1609 745776001871 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745776001872 DNA binding site [nucleotide binding] 745776001873 domain linker motif; other site 745776001874 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 745776001875 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 745776001876 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 745776001877 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 745776001878 Major royal jelly protein; Region: MRJP; pfam03022 745776001879 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 745776001880 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 745776001881 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776001882 ABC transporter signature motif; other site 745776001883 Walker B; other site 745776001884 D-loop; other site 745776001885 H-loop/switch region; other site 745776001886 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 745776001887 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 745776001888 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 745776001889 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 745776001890 putative substrate binding pocket [chemical binding]; other site 745776001891 trimer interface [polypeptide binding]; other site 745776001892 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 745776001893 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 745776001894 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 745776001895 active site 745776001896 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 745776001897 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 745776001898 tetramer interface [polypeptide binding]; other site 745776001899 active site 745776001900 metal binding site [ion binding]; metal-binding site 745776001901 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 745776001902 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 745776001903 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 745776001904 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 745776001905 NAD binding site [chemical binding]; other site 745776001906 catalytic residues [active] 745776001907 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 745776001908 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 745776001909 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 745776001910 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 745776001911 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 745776001912 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 745776001913 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 745776001914 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 745776001915 dimer interface [polypeptide binding]; other site 745776001916 active site 745776001917 Cupin domain; Region: Cupin_2; pfam07883 745776001918 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 745776001919 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 745776001920 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 745776001921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776001922 dimer interface [polypeptide binding]; other site 745776001923 conserved gate region; other site 745776001924 putative PBP binding loops; other site 745776001925 ABC-ATPase subunit interface; other site 745776001926 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 745776001927 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776001928 dimer interface [polypeptide binding]; other site 745776001929 conserved gate region; other site 745776001930 putative PBP binding loops; other site 745776001931 ABC-ATPase subunit interface; other site 745776001932 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 745776001933 GAF domain; Region: GAF; pfam01590 745776001934 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 745776001935 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 745776001936 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745776001937 metal binding site [ion binding]; metal-binding site 745776001938 active site 745776001939 I-site; other site 745776001940 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 745776001941 GAF domain; Region: GAF; pfam01590 745776001942 PAS fold; Region: PAS_3; pfam08447 745776001943 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 745776001944 heme pocket [chemical binding]; other site 745776001945 putative active site [active] 745776001946 PAS fold; Region: PAS_4; pfam08448 745776001947 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 745776001948 putative active site [active] 745776001949 heme pocket [chemical binding]; other site 745776001950 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 745776001951 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745776001952 metal binding site [ion binding]; metal-binding site 745776001953 active site 745776001954 I-site; other site 745776001955 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 745776001956 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 745776001957 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 745776001958 Ca binding site [ion binding]; other site 745776001959 active site 745776001960 catalytic site [active] 745776001961 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 745776001962 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 745776001963 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 745776001964 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 745776001965 calcium binding site 2 [ion binding]; other site 745776001966 active site 745776001967 catalytic triad [active] 745776001968 calcium binding site 1 [ion binding]; other site 745776001969 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 745776001970 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 745776001971 NodB motif; other site 745776001972 active site 745776001973 catalytic site [active] 745776001974 metal binding site [ion binding]; metal-binding site 745776001975 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 745776001976 hypothetical protein; Provisional; Region: PRK06062 745776001977 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 745776001978 inhibitor-cofactor binding pocket; inhibition site 745776001979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745776001980 catalytic residue [active] 745776001981 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 745776001982 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 745776001983 tetrameric interface [polypeptide binding]; other site 745776001984 NAD binding site [chemical binding]; other site 745776001985 catalytic residues [active] 745776001986 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 745776001987 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776001988 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 745776001989 Walker A/P-loop; other site 745776001990 ATP binding site [chemical binding]; other site 745776001991 Q-loop/lid; other site 745776001992 ABC transporter signature motif; other site 745776001993 Walker B; other site 745776001994 D-loop; other site 745776001995 H-loop/switch region; other site 745776001996 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 745776001997 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 745776001998 dimer interface [polypeptide binding]; other site 745776001999 active site 745776002000 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 745776002001 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 745776002002 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 745776002003 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 745776002004 catalytic triad [active] 745776002005 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 745776002006 metal ion-dependent adhesion site (MIDAS); other site 745776002007 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745776002008 S-adenosylmethionine binding site [chemical binding]; other site 745776002009 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 745776002010 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 745776002011 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 745776002012 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 745776002013 High-affinity nickel-transport protein; Region: NicO; cl00964 745776002014 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 745776002015 metal ion-dependent adhesion site (MIDAS); other site 745776002016 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 745776002017 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 745776002018 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745776002019 Walker A motif; other site 745776002020 ATP binding site [chemical binding]; other site 745776002021 Walker B motif; other site 745776002022 arginine finger; other site 745776002023 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 745776002024 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 745776002025 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 745776002026 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 745776002027 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 745776002028 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 745776002029 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 745776002030 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 745776002031 phosphopeptide binding site; other site 745776002032 phage tail protein domain; Region: tail_TIGR02242 745776002033 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 745776002034 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 745776002035 Catalytic domain of Protein Kinases; Region: PKc; cd00180 745776002036 active site 745776002037 ATP binding site [chemical binding]; other site 745776002038 substrate binding site [chemical binding]; other site 745776002039 activation loop (A-loop); other site 745776002040 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 745776002041 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 745776002042 phosphopeptide binding site; other site 745776002043 Phage protein D [General function prediction only]; Region: COG3500 745776002044 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 745776002045 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 745776002046 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 745776002047 putative NAD(P) binding site [chemical binding]; other site 745776002048 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745776002049 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 745776002050 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 745776002051 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 745776002052 putative active site [active] 745776002053 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 745776002054 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 745776002055 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 745776002056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776002057 putative PBP binding loops; other site 745776002058 ABC-ATPase subunit interface; other site 745776002059 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 745776002060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776002061 putative PBP binding loops; other site 745776002062 ABC-ATPase subunit interface; other site 745776002063 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 745776002064 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 745776002065 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 745776002066 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 745776002067 dimer interface [polypeptide binding]; other site 745776002068 active site 745776002069 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 745776002070 dimer interface [polypeptide binding]; other site 745776002071 active site 745776002072 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 745776002073 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 745776002074 tetramerization interface [polypeptide binding]; other site 745776002075 NAD(P) binding site [chemical binding]; other site 745776002076 catalytic residues [active] 745776002077 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 745776002078 cleavage site 745776002079 active site 745776002080 substrate binding sites [chemical binding]; other site 745776002081 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 745776002082 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 745776002083 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 745776002084 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 745776002085 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 745776002086 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 745776002087 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 745776002088 catalytic loop [active] 745776002089 iron binding site [ion binding]; other site 745776002090 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 745776002091 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 745776002092 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 745776002093 P-loop; other site 745776002094 Magnesium ion binding site [ion binding]; other site 745776002095 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 745776002096 Magnesium ion binding site [ion binding]; other site 745776002097 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 745776002098 ParB-like nuclease domain; Region: ParB; smart00470 745776002099 Predicted transcriptional regulator [Transcription]; Region: COG2378 745776002100 HTH domain; Region: HTH_11; pfam08279 745776002101 WYL domain; Region: WYL; pfam13280 745776002102 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 745776002103 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 745776002104 siderophore binding site; other site 745776002105 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 745776002106 SnoaL-like domain; Region: SnoaL_2; pfam12680 745776002107 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 745776002108 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 745776002109 allantoate amidohydrolase; Reviewed; Region: PRK09290 745776002110 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 745776002111 active site 745776002112 metal binding site [ion binding]; metal-binding site 745776002113 dimer interface [polypeptide binding]; other site 745776002114 NMT1/THI5 like; Region: NMT1; pfam09084 745776002115 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 745776002116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 745776002117 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 745776002118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776002119 dimer interface [polypeptide binding]; other site 745776002120 conserved gate region; other site 745776002121 ABC-ATPase subunit interface; other site 745776002122 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 745776002123 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 745776002124 Walker A/P-loop; other site 745776002125 ATP binding site [chemical binding]; other site 745776002126 Q-loop/lid; other site 745776002127 ABC transporter signature motif; other site 745776002128 Walker B; other site 745776002129 D-loop; other site 745776002130 H-loop/switch region; other site 745776002131 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 745776002132 active site 745776002133 tetramer interface [polypeptide binding]; other site 745776002134 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 745776002135 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 745776002136 homodimer interface [polypeptide binding]; other site 745776002137 active site 745776002138 FMN binding site [chemical binding]; other site 745776002139 substrate binding site [chemical binding]; other site 745776002140 4Fe-4S binding domain; Region: Fer4; cl02805 745776002141 4Fe-4S binding domain; Region: Fer4; pfam00037 745776002142 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 745776002143 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 745776002144 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 745776002145 PAS domain S-box; Region: sensory_box; TIGR00229 745776002146 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 745776002147 putative active site [active] 745776002148 heme pocket [chemical binding]; other site 745776002149 GAF domain; Region: GAF_2; pfam13185 745776002150 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745776002151 dimer interface [polypeptide binding]; other site 745776002152 phosphorylation site [posttranslational modification] 745776002153 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776002154 ATP binding site [chemical binding]; other site 745776002155 Mg2+ binding site [ion binding]; other site 745776002156 G-X-G motif; other site 745776002157 Predicted flavoprotein [General function prediction only]; Region: COG0431 745776002158 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 745776002159 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 745776002160 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 745776002161 dimerization interface [polypeptide binding]; other site 745776002162 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 745776002163 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 745776002164 Ligand Binding Site [chemical binding]; other site 745776002165 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 745776002166 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 745776002167 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 745776002168 Soluble P-type ATPase [General function prediction only]; Region: COG4087 745776002169 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 745776002170 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 745776002171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776002172 ATP binding site [chemical binding]; other site 745776002173 Mg2+ binding site [ion binding]; other site 745776002174 G-X-G motif; other site 745776002175 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 745776002176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776002177 active site 745776002178 phosphorylation site [posttranslational modification] 745776002179 intermolecular recognition site; other site 745776002180 dimerization interface [polypeptide binding]; other site 745776002181 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 745776002182 DNA binding residues [nucleotide binding] 745776002183 dimerization interface [polypeptide binding]; other site 745776002184 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 745776002185 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 745776002186 Transcriptional regulator [Transcription]; Region: IclR; COG1414 745776002187 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 745776002188 Bacterial transcriptional regulator; Region: IclR; pfam01614 745776002189 urocanate hydratase; Provisional; Region: PRK05414 745776002190 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 745776002191 agmatinase; Region: agmatinase; TIGR01230 745776002192 active site 745776002193 metal binding site [ion binding]; metal-binding site 745776002194 imidazolonepropionase; Validated; Region: PRK09356 745776002195 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 745776002196 active site 745776002197 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 745776002198 active sites [active] 745776002199 tetramer interface [polypeptide binding]; other site 745776002200 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 745776002201 SWIM zinc finger; Region: SWIM; pfam04434 745776002202 MoxR-like ATPases [General function prediction only]; Region: COG0714 745776002203 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 745776002204 Leucine rich repeat; Region: LRR_8; pfam13855 745776002205 Leucine rich repeat; Region: LRR_8; pfam13855 745776002206 Leucine rich repeat; Region: LRR_8; pfam13855 745776002207 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 745776002208 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 745776002209 metal ion-dependent adhesion site (MIDAS); other site 745776002210 Predicted membrane protein [Function unknown]; Region: COG4325 745776002211 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 745776002212 GAF domain; Region: GAF; pfam01590 745776002213 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 745776002214 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 745776002215 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 745776002216 putative active site [active] 745776002217 heme pocket [chemical binding]; other site 745776002218 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745776002219 dimer interface [polypeptide binding]; other site 745776002220 phosphorylation site [posttranslational modification] 745776002221 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776002222 ATP binding site [chemical binding]; other site 745776002223 Mg2+ binding site [ion binding]; other site 745776002224 G-X-G motif; other site 745776002225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776002226 active site 745776002227 phosphorylation site [posttranslational modification] 745776002228 intermolecular recognition site; other site 745776002229 dimerization interface [polypeptide binding]; other site 745776002230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745776002231 Major Facilitator Superfamily; Region: MFS_1; pfam07690 745776002232 putative substrate translocation pore; other site 745776002233 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 745776002234 MarR family; Region: MarR; pfam01047 745776002235 NMT1/THI5 like; Region: NMT1; pfam09084 745776002236 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776002237 ABC transporter signature motif; other site 745776002238 Walker B; other site 745776002239 D-loop; other site 745776002240 H-loop/switch region; other site 745776002241 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 745776002242 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 745776002243 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 745776002244 PAAR motif; Region: PAAR_motif; pfam05488 745776002245 Response regulator receiver domain; Region: Response_reg; pfam00072 745776002246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776002247 active site 745776002248 phosphorylation site [posttranslational modification] 745776002249 intermolecular recognition site; other site 745776002250 dimerization interface [polypeptide binding]; other site 745776002251 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 745776002252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776002253 active site 745776002254 phosphorylation site [posttranslational modification] 745776002255 intermolecular recognition site; other site 745776002256 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 745776002257 active site 745776002258 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 745776002259 active site 745776002260 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 745776002261 putative substrate binding site [chemical binding]; other site 745776002262 active site 745776002263 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 745776002264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776002265 dimer interface [polypeptide binding]; other site 745776002266 conserved gate region; other site 745776002267 putative PBP binding loops; other site 745776002268 ABC-ATPase subunit interface; other site 745776002269 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776002270 putative PBP binding loops; other site 745776002271 dimer interface [polypeptide binding]; other site 745776002272 ABC-ATPase subunit interface; other site 745776002273 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 745776002274 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 745776002275 Predicted transcriptional regulator [Transcription]; Region: COG4189 745776002276 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 745776002277 putative DNA binding site [nucleotide binding]; other site 745776002278 dimerization interface [polypeptide binding]; other site 745776002279 putative Zn2+ binding site [ion binding]; other site 745776002280 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 745776002281 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 745776002282 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 745776002283 amphipathic channel; other site 745776002284 Asn-Pro-Ala signature motifs; other site 745776002285 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 745776002286 PRC-barrel domain; Region: PRC; pfam05239 745776002287 PRC-barrel domain; Region: PRC; pfam05239 745776002288 Predicted transcriptional regulator [Transcription]; Region: COG2378 745776002289 WYL domain; Region: WYL; pfam13280 745776002290 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 745776002291 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 745776002292 binding surface 745776002293 TPR motif; other site 745776002294 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 745776002295 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 745776002296 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 745776002297 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 745776002298 metal-binding site [ion binding] 745776002299 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 745776002300 Soluble P-type ATPase [General function prediction only]; Region: COG4087 745776002301 PAS domain; Region: PAS_9; pfam13426 745776002302 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745776002303 dimer interface [polypeptide binding]; other site 745776002304 phosphorylation site [posttranslational modification] 745776002305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776002306 ATP binding site [chemical binding]; other site 745776002307 Mg2+ binding site [ion binding]; other site 745776002308 G-X-G motif; other site 745776002309 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 745776002310 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 745776002311 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 745776002312 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 745776002313 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 745776002314 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 745776002315 substrate binding site [chemical binding]; other site 745776002316 ATP binding site [chemical binding]; other site 745776002317 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 745776002318 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 745776002319 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 745776002320 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 745776002321 Walker A/P-loop; other site 745776002322 ATP binding site [chemical binding]; other site 745776002323 Q-loop/lid; other site 745776002324 ABC transporter signature motif; other site 745776002325 Walker B; other site 745776002326 D-loop; other site 745776002327 H-loop/switch region; other site 745776002328 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 745776002329 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 745776002330 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 745776002331 TM-ABC transporter signature motif; other site 745776002332 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 745776002333 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 745776002334 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 745776002335 Transcriptional regulators [Transcription]; Region: PurR; COG1609 745776002336 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745776002337 DNA binding site [nucleotide binding] 745776002338 domain linker motif; other site 745776002339 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_9; cd06290 745776002340 putative dimerization interface [polypeptide binding]; other site 745776002341 putative ligand binding site [chemical binding]; other site 745776002342 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 745776002343 active site 745776002344 catalytic residues [active] 745776002345 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 745776002346 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 745776002347 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 745776002348 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 745776002349 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 745776002350 putative anti-sigmaE protein; Provisional; Region: PRK13920 745776002351 Putative zinc-finger; Region: zf-HC2; pfam13490 745776002352 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 745776002353 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 745776002354 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 745776002355 DNA binding residues [nucleotide binding] 745776002356 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 745776002357 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 745776002358 active site 745776002359 catalytic tetrad [active] 745776002360 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 745776002361 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 745776002362 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 745776002363 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 745776002364 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 745776002365 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 745776002366 Predicted ATPase [General function prediction only]; Region: COG3903 745776002367 Tetratricopeptide repeat; Region: TPR_12; pfam13424 745776002368 Tetratricopeptide repeat; Region: TPR_12; pfam13424 745776002369 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 745776002370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745776002371 NAD(P) binding site [chemical binding]; other site 745776002372 active site 745776002373 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 745776002374 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 745776002375 3-oxoacyl-acyl-carrier-protein synthase 3; Provisional; Region: fabH; CHL00203 745776002376 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 745776002377 active site 745776002378 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 745776002379 ApbE family; Region: ApbE; pfam02424 745776002380 CCC1-related family of proteins; Region: CCC1_like; cl00278 745776002381 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 745776002382 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745776002383 phosphorylation site [posttranslational modification] 745776002384 dimer interface [polypeptide binding]; other site 745776002385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776002386 ATP binding site [chemical binding]; other site 745776002387 Mg2+ binding site [ion binding]; other site 745776002388 G-X-G motif; other site 745776002389 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 745776002390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776002391 active site 745776002392 phosphorylation site [posttranslational modification] 745776002393 intermolecular recognition site; other site 745776002394 dimerization interface [polypeptide binding]; other site 745776002395 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 745776002396 DNA binding site [nucleotide binding] 745776002397 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 745776002398 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 745776002399 DPS ferroxidase diiron center [ion binding]; other site 745776002400 dimerization interface [polypeptide binding]; other site 745776002401 ion pore; other site 745776002402 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 745776002403 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 745776002404 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 745776002405 active site 745776002406 Transcriptional regulator [Transcription]; Region: IclR; COG1414 745776002407 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 745776002408 putative DNA binding site [nucleotide binding]; other site 745776002409 putative Zn2+ binding site [ion binding]; other site 745776002410 Bacterial transcriptional regulator; Region: IclR; pfam01614 745776002411 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 745776002412 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 745776002413 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 745776002414 peptide binding site [polypeptide binding]; other site 745776002415 dimer interface [polypeptide binding]; other site 745776002416 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 745776002417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776002418 dimer interface [polypeptide binding]; other site 745776002419 conserved gate region; other site 745776002420 putative PBP binding loops; other site 745776002421 ABC-ATPase subunit interface; other site 745776002422 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 745776002423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776002424 dimer interface [polypeptide binding]; other site 745776002425 conserved gate region; other site 745776002426 putative PBP binding loops; other site 745776002427 ABC-ATPase subunit interface; other site 745776002428 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 745776002429 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 745776002430 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 745776002431 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 745776002432 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 745776002433 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 745776002434 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 745776002435 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 745776002436 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 745776002437 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 745776002438 putative NAD(P) binding site [chemical binding]; other site 745776002439 putative active site [active] 745776002440 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 745776002441 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 745776002442 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 745776002443 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cl03727 745776002444 dimer interface [polypeptide binding]; other site 745776002445 catalytic residues [active] 745776002446 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 745776002447 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 745776002448 urease subunit alpha; Reviewed; Region: ureC; PRK13207 745776002449 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 745776002450 subunit interactions [polypeptide binding]; other site 745776002451 active site 745776002452 flap region; other site 745776002453 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 745776002454 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 745776002455 alpha-gamma subunit interface [polypeptide binding]; other site 745776002456 beta-gamma subunit interface [polypeptide binding]; other site 745776002457 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 745776002458 alpha-beta subunit interface [polypeptide binding]; other site 745776002459 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 745776002460 UreD urease accessory protein; Region: UreD; cl00530 745776002461 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 745776002462 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 745776002463 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 745776002464 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 745776002465 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 745776002466 substrate binding site [chemical binding]; other site 745776002467 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 745776002468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776002469 dimer interface [polypeptide binding]; other site 745776002470 conserved gate region; other site 745776002471 putative PBP binding loops; other site 745776002472 ABC-ATPase subunit interface; other site 745776002473 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 745776002474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776002475 dimer interface [polypeptide binding]; other site 745776002476 conserved gate region; other site 745776002477 putative PBP binding loops; other site 745776002478 ABC-ATPase subunit interface; other site 745776002479 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 745776002480 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745776002481 Walker A/P-loop; other site 745776002482 ATP binding site [chemical binding]; other site 745776002483 Q-loop/lid; other site 745776002484 ABC transporter signature motif; other site 745776002485 Walker B; other site 745776002486 D-loop; other site 745776002487 H-loop/switch region; other site 745776002488 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745776002489 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 745776002490 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745776002491 Walker A/P-loop; other site 745776002492 ATP binding site [chemical binding]; other site 745776002493 Q-loop/lid; other site 745776002494 ABC transporter signature motif; other site 745776002495 Walker B; other site 745776002496 D-loop; other site 745776002497 H-loop/switch region; other site 745776002498 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745776002499 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 745776002500 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 745776002501 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 745776002502 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 745776002503 2-enoyl thioester reductase (ETR) like proteins, child 2; Region: ETR_like_2; cd08292 745776002504 putative NAD(P) binding site [chemical binding]; other site 745776002505 putative dimer interface [polypeptide binding]; other site 745776002506 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 745776002507 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745776002508 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 745776002509 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 745776002510 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 745776002511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776002512 dimer interface [polypeptide binding]; other site 745776002513 conserved gate region; other site 745776002514 putative PBP binding loops; other site 745776002515 ABC-ATPase subunit interface; other site 745776002516 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 745776002517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776002518 ABC-ATPase subunit interface; other site 745776002519 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 745776002520 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745776002521 Walker A/P-loop; other site 745776002522 ATP binding site [chemical binding]; other site 745776002523 Q-loop/lid; other site 745776002524 ABC transporter signature motif; other site 745776002525 Walker B; other site 745776002526 D-loop; other site 745776002527 H-loop/switch region; other site 745776002528 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745776002529 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 745776002530 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745776002531 Walker A/P-loop; other site 745776002532 ATP binding site [chemical binding]; other site 745776002533 Q-loop/lid; other site 745776002534 ABC transporter signature motif; other site 745776002535 Walker B; other site 745776002536 D-loop; other site 745776002537 H-loop/switch region; other site 745776002538 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745776002539 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745776002540 DNA-binding site [nucleotide binding]; DNA binding site 745776002541 Creatinine amidohydrolase; Region: Creatininase; pfam02633 745776002542 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 745776002543 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 745776002544 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 745776002545 classical (c) SDRs; Region: SDR_c; cd05233 745776002546 NAD(P) binding site [chemical binding]; other site 745776002547 active site 745776002548 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 745776002549 hypothetical protein; Validated; Region: PRK09104 745776002550 metal binding site [ion binding]; metal-binding site 745776002551 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 745776002552 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 745776002553 active site 745776002554 Zn binding site [ion binding]; other site 745776002555 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 745776002556 active site 745776002557 catalytic site [active] 745776002558 Starch binding domain; Region: CBM_20; pfam00686 745776002559 starch-binding site 2 [chemical binding]; other site 745776002560 starch-binding site 1 [chemical binding]; other site 745776002561 Transcriptional regulator [Transcription]; Region: IclR; COG1414 745776002562 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 745776002563 Tetratricopeptide repeat; Region: TPR_12; pfam13424 745776002564 Tetratricopeptide repeat; Region: TPR_12; pfam13424 745776002565 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 745776002566 binding surface 745776002567 TPR motif; other site 745776002568 Tetratricopeptide repeat; Region: TPR_12; pfam13424 745776002569 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 745776002570 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 745776002571 calcium binding site 2 [ion binding]; other site 745776002572 active site 745776002573 catalytic triad [active] 745776002574 calcium binding site 1 [ion binding]; other site 745776002575 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 745776002576 multidrug efflux protein; Reviewed; Region: PRK01766 745776002577 cation binding site [ion binding]; other site 745776002578 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 745776002579 putative active site [active] 745776002580 heme pocket [chemical binding]; other site 745776002581 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 745776002582 PAS fold; Region: PAS_3; pfam08447 745776002583 putative active site [active] 745776002584 heme pocket [chemical binding]; other site 745776002585 PAS domain S-box; Region: sensory_box; TIGR00229 745776002586 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 745776002587 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745776002588 dimer interface [polypeptide binding]; other site 745776002589 phosphorylation site [posttranslational modification] 745776002590 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776002591 ATP binding site [chemical binding]; other site 745776002592 Mg2+ binding site [ion binding]; other site 745776002593 G-X-G motif; other site 745776002594 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 745776002595 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745776002596 Coenzyme A binding pocket [chemical binding]; other site 745776002597 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 745776002598 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745776002599 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 745776002600 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 745776002601 dimerization interface [polypeptide binding]; other site 745776002602 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 745776002603 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745776002604 phosphorylation site [posttranslational modification] 745776002605 dimer interface [polypeptide binding]; other site 745776002606 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776002607 ATP binding site [chemical binding]; other site 745776002608 Mg2+ binding site [ion binding]; other site 745776002609 G-X-G motif; other site 745776002610 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 745776002611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776002612 active site 745776002613 phosphorylation site [posttranslational modification] 745776002614 intermolecular recognition site; other site 745776002615 dimerization interface [polypeptide binding]; other site 745776002616 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 745776002617 DNA binding site [nucleotide binding] 745776002618 YceI-like domain; Region: YceI; smart00867 745776002619 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 745776002620 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 745776002621 Tellurium resistance protein; Region: Tellurium_res; pfam10138 745776002622 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 745776002623 putative metal binding site [ion binding]; other site 745776002624 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 745776002625 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 745776002626 putative metal binding site [ion binding]; other site 745776002627 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 745776002628 metal ion-dependent adhesion site (MIDAS); other site 745776002629 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 745776002630 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 745776002631 putative metal binding site [ion binding]; other site 745776002632 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 745776002633 active site 745776002634 putative homodimer interface [polypeptide binding]; other site 745776002635 SAM binding site [chemical binding]; other site 745776002636 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 745776002637 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 745776002638 putative active site [active] 745776002639 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 745776002640 putative active site [active] 745776002641 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 745776002642 Precorrin-8X methylmutase; Region: CbiC; pfam02570 745776002643 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 745776002644 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 745776002645 homodimer interface [polypeptide binding]; other site 745776002646 active site 745776002647 SAM binding site [chemical binding]; other site 745776002648 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 745776002649 active site 745776002650 SAM binding site [chemical binding]; other site 745776002651 homodimer interface [polypeptide binding]; other site 745776002652 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 745776002653 cobalamin biosynthesis protein CbiG; Provisional; Region: PRK07027 745776002654 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 745776002655 homodimer interface [polypeptide binding]; other site 745776002656 active site 745776002657 SAM binding site [chemical binding]; other site 745776002658 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 745776002659 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 745776002660 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 745776002661 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 745776002662 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 745776002663 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 745776002664 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 745776002665 Domain of unknown function (DUF336); Region: DUF336; pfam03928 745776002666 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 745776002667 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776002668 active site 745776002669 phosphorylation site [posttranslational modification] 745776002670 intermolecular recognition site; other site 745776002671 dimerization interface [polypeptide binding]; other site 745776002672 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 745776002673 DNA binding residues [nucleotide binding] 745776002674 dimerization interface [polypeptide binding]; other site 745776002675 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 745776002676 PAS domain; Region: PAS_9; pfam13426 745776002677 heme pocket [chemical binding]; other site 745776002678 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745776002679 dimer interface [polypeptide binding]; other site 745776002680 phosphorylation site [posttranslational modification] 745776002681 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776002682 ATP binding site [chemical binding]; other site 745776002683 Mg2+ binding site [ion binding]; other site 745776002684 G-X-G motif; other site 745776002685 Uncharacterized conserved protein [Function unknown]; Region: COG3375 745776002686 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 745776002687 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 745776002688 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 745776002689 ATP binding site [chemical binding]; other site 745776002690 putative Mg++ binding site [ion binding]; other site 745776002691 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 745776002692 nucleotide binding region [chemical binding]; other site 745776002693 ATP-binding site [chemical binding]; other site 745776002694 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 745776002695 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 745776002696 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 745776002697 FeS/SAM binding site; other site 745776002698 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 745776002699 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 745776002700 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 745776002701 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 745776002702 Predicted methyltransferases [General function prediction only]; Region: COG0313 745776002703 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 745776002704 putative SAM binding site [chemical binding]; other site 745776002705 putative homodimer interface [polypeptide binding]; other site 745776002706 6-phosphofructokinase; Provisional; Region: PRK03202 745776002707 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 745776002708 active site 745776002709 ADP/pyrophosphate binding site [chemical binding]; other site 745776002710 dimerization interface [polypeptide binding]; other site 745776002711 allosteric effector site; other site 745776002712 fructose-1,6-bisphosphate binding site; other site 745776002713 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 745776002714 putative catalytic site [active] 745776002715 putative metal binding site [ion binding]; other site 745776002716 putative phosphate binding site [ion binding]; other site 745776002717 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 745776002718 VanW like protein; Region: VanW; pfam04294 745776002719 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 745776002720 Fasciclin domain; Region: Fasciclin; pfam02469 745776002721 cell division protein FtsZ; Validated; Region: PRK09330 745776002722 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 745776002723 nucleotide binding site [chemical binding]; other site 745776002724 SulA interaction site; other site 745776002725 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 745776002726 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 745776002727 nucleotide binding site [chemical binding]; other site 745776002728 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 745776002729 Cell division protein FtsA; Region: FtsA; pfam14450 745776002730 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 745776002731 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 745776002732 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14651 745776002733 FAD binding domain; Region: FAD_binding_4; pfam01565 745776002734 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 745776002735 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 745776002736 UDP-N-acetylmuramate--alanine ligase; Region: murC; TIGR01082 745776002737 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 745776002738 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 745776002739 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 745776002740 active site 745776002741 homodimer interface [polypeptide binding]; other site 745776002742 Uncharacterized conserved protein [Function unknown]; Region: COG2013 745776002743 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 745776002744 putative FMN binding site [chemical binding]; other site 745776002745 aspartate aminotransferase; Provisional; Region: PRK05764 745776002746 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 745776002747 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745776002748 homodimer interface [polypeptide binding]; other site 745776002749 catalytic residue [active] 745776002750 hypothetical protein; Reviewed; Region: PRK12497 745776002751 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 745776002752 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745776002753 motif II; other site 745776002754 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 745776002755 dsRNA binding site [nucleotide binding]; other site 745776002756 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 745776002757 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 745776002758 NAD binding site [chemical binding]; other site 745776002759 catalytic Zn binding site [ion binding]; other site 745776002760 structural Zn binding site [ion binding]; other site 745776002761 excinuclease ABC subunit B; Provisional; Region: PRK05298 745776002762 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 745776002763 ATP binding site [chemical binding]; other site 745776002764 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 745776002765 nucleotide binding region [chemical binding]; other site 745776002766 ATP-binding site [chemical binding]; other site 745776002767 Ultra-violet resistance protein B; Region: UvrB; pfam12344 745776002768 UvrB/uvrC motif; Region: UVR; pfam02151 745776002769 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745776002770 S-adenosylmethionine binding site [chemical binding]; other site 745776002771 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 745776002772 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 745776002773 active site 745776002774 catalytic site [active] 745776002775 substrate binding site [chemical binding]; other site 745776002776 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 745776002777 GTPase Era; Reviewed; Region: era; PRK00089 745776002778 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 745776002779 G1 box; other site 745776002780 GTP/Mg2+ binding site [chemical binding]; other site 745776002781 Switch I region; other site 745776002782 G2 box; other site 745776002783 Switch II region; other site 745776002784 G3 box; other site 745776002785 G4 box; other site 745776002786 G5 box; other site 745776002787 KH domain; Region: KH_2; pfam07650 745776002788 Cation transport protein; Region: TrkH; cl17365 745776002789 Arginase family; Region: Arginase; cd09989 745776002790 active site 745776002791 Mn binding site [ion binding]; other site 745776002792 oligomer interface [polypeptide binding]; other site 745776002793 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 745776002794 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 745776002795 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 745776002796 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 745776002797 active site 745776002798 metal binding site [ion binding]; metal-binding site 745776002799 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 745776002800 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 745776002801 Serine hydrolase; Region: Ser_hydrolase; pfam06821 745776002802 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 745776002803 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 745776002804 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 745776002805 catalytic residues [active] 745776002806 LabA_like proteins; Region: LabA_like/DUF88; cl10034 745776002807 Uncharacterized conserved protein [Function unknown]; Region: COG1432 745776002808 putative metal binding site [ion binding]; other site 745776002809 putative phosphate acyltransferase; Provisional; Region: PRK05331 745776002810 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 745776002811 Mechanosensitive ion channel; Region: MS_channel; pfam00924 745776002812 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 745776002813 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 745776002814 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 745776002815 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 745776002816 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 745776002817 Uncharacterized conserved protein [Function unknown]; Region: COG2308 745776002818 Protein of unknown function (DUF1517); Region: DUF1517; cl01807 745776002819 Putative cyclase; Region: Cyclase; cl00814 745776002820 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 745776002821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776002822 ATP binding site [chemical binding]; other site 745776002823 Mg2+ binding site [ion binding]; other site 745776002824 G-X-G motif; other site 745776002825 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 745776002826 anchoring element; other site 745776002827 dimer interface [polypeptide binding]; other site 745776002828 ATP binding site [chemical binding]; other site 745776002829 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 745776002830 active site 745776002831 putative metal-binding site [ion binding]; other site 745776002832 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 745776002833 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 745776002834 metal ion-dependent adhesion site (MIDAS); other site 745776002835 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 745776002836 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 745776002837 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 745776002838 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 745776002839 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 745776002840 Ribosome-binding factor A; Region: RBFA; pfam02033 745776002841 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 745776002842 active site 745776002843 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 745776002844 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 745776002845 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745776002846 dimer interface [polypeptide binding]; other site 745776002847 phosphorylation site [posttranslational modification] 745776002848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776002849 ATP binding site [chemical binding]; other site 745776002850 Mg2+ binding site [ion binding]; other site 745776002851 G-X-G motif; other site 745776002852 phytoene desaturase; Region: crtI_fam; TIGR02734 745776002853 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 745776002854 active site lid residues [active] 745776002855 substrate binding pocket [chemical binding]; other site 745776002856 catalytic residues [active] 745776002857 substrate-Mg2+ binding site; other site 745776002858 aspartate-rich region 1; other site 745776002859 aspartate-rich region 2; other site 745776002860 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745776002861 S-adenosylmethionine binding site [chemical binding]; other site 745776002862 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 745776002863 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 745776002864 metal binding site 2 [ion binding]; metal-binding site 745776002865 putative DNA binding helix; other site 745776002866 metal binding site 1 [ion binding]; metal-binding site 745776002867 dimer interface [polypeptide binding]; other site 745776002868 structural Zn2+ binding site [ion binding]; other site 745776002869 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 745776002870 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 745776002871 active site 745776002872 catalytic site [active] 745776002873 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745776002874 Coenzyme A binding pocket [chemical binding]; other site 745776002875 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 745776002876 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 745776002877 23S rRNA binding site [nucleotide binding]; other site 745776002878 L21 binding site [polypeptide binding]; other site 745776002879 L13 binding site [polypeptide binding]; other site 745776002880 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 745776002881 putative substrate binding pocket [chemical binding]; other site 745776002882 AC domain interface; other site 745776002883 catalytic triad [active] 745776002884 AB domain interface; other site 745776002885 interchain disulfide; other site 745776002886 Uncharacterized conserved protein [Function unknown]; Region: COG1359 745776002887 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK14811 745776002888 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 745776002889 DNA binding site [nucleotide binding] 745776002890 catalytic residue [active] 745776002891 H2TH interface [polypeptide binding]; other site 745776002892 putative catalytic residues [active] 745776002893 turnover-facilitating residue; other site 745776002894 intercalation triad [nucleotide binding]; other site 745776002895 8OG recognition residue [nucleotide binding]; other site 745776002896 putative reading head residues; other site 745776002897 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 745776002898 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 745776002899 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 745776002900 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 745776002901 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 745776002902 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 745776002903 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 745776002904 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 745776002905 2-phosphoglycerate kinase; Provisional; Region: PRK12337 745776002906 ATP cone domain; Region: ATP-cone; pfam03477 745776002907 AAA domain; Region: AAA_17; pfam13207 745776002908 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 745776002909 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745776002910 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 745776002911 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 745776002912 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 745776002913 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 745776002914 Competence protein; Region: Competence; pfam03772 745776002915 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 745776002916 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 745776002917 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 745776002918 homotrimer interaction site [polypeptide binding]; other site 745776002919 putative active site [active] 745776002920 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 745776002921 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 745776002922 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 745776002923 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 745776002924 active site 745776002925 catalytic tetrad [active] 745776002926 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 745776002927 DHH family; Region: DHH; pfam01368 745776002928 DHHA1 domain; Region: DHHA1; pfam02272 745776002929 S-layer homology domain; Region: SLH; pfam00395 745776002930 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 745776002931 substrate binding site [chemical binding]; other site 745776002932 oxyanion hole (OAH) forming residues; other site 745776002933 trimer interface [polypeptide binding]; other site 745776002934 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 745776002935 HD supefamily hydrolase [General function prediction only]; Region: COG3294 745776002936 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 745776002937 VanW like protein; Region: VanW; pfam04294 745776002938 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 745776002939 active site 745776002940 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 745776002941 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 745776002942 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 745776002943 methionine sulfoxide reductase B; Provisional; Region: PRK00222 745776002944 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 745776002945 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 745776002946 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 745776002947 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 745776002948 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 745776002949 Walker A/P-loop; other site 745776002950 ATP binding site [chemical binding]; other site 745776002951 Q-loop/lid; other site 745776002952 ABC transporter signature motif; other site 745776002953 Walker B; other site 745776002954 D-loop; other site 745776002955 H-loop/switch region; other site 745776002956 M20 Peptidase acetylornithine deacetylase/acetyl-lysine deacetylase; Region: M20_ArgE_LysK; cd05653 745776002957 acetyl-lysine deacetylase; Provisional; Region: PRK04443 745776002958 metal binding site [ion binding]; metal-binding site 745776002959 putative dimer interface [polypeptide binding]; other site 745776002960 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 745776002961 transmembrane helices; other site 745776002962 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 745776002963 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 745776002964 TrkA-C domain; Region: TrkA_C; pfam02080 745776002965 TrkA-C domain; Region: TrkA_C; pfam02080 745776002966 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 745776002967 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 745776002968 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 745776002969 active site 745776002970 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 745776002971 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 745776002972 S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501 745776002973 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 745776002974 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 745776002975 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 745776002976 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 745776002977 Walker A/P-loop; other site 745776002978 ATP binding site [chemical binding]; other site 745776002979 Q-loop/lid; other site 745776002980 ABC transporter signature motif; other site 745776002981 Walker B; other site 745776002982 D-loop; other site 745776002983 H-loop/switch region; other site 745776002984 phosphopentomutase; Provisional; Region: PRK05362 745776002985 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 745776002986 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 745776002987 Peptidase family M48; Region: Peptidase_M48; cl12018 745776002988 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 745776002989 histidinol dehydrogenase; Region: hisD; TIGR00069 745776002990 NAD binding site [chemical binding]; other site 745776002991 dimerization interface [polypeptide binding]; other site 745776002992 product binding site; other site 745776002993 substrate binding site [chemical binding]; other site 745776002994 zinc binding site [ion binding]; other site 745776002995 catalytic residues [active] 745776002996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 745776002997 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 745776002998 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 745776002999 Walker A/P-loop; other site 745776003000 ATP binding site [chemical binding]; other site 745776003001 Q-loop/lid; other site 745776003002 ABC transporter signature motif; other site 745776003003 Walker B; other site 745776003004 D-loop; other site 745776003005 H-loop/switch region; other site 745776003006 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 745776003007 synthetase active site [active] 745776003008 NTP binding site [chemical binding]; other site 745776003009 metal binding site [ion binding]; metal-binding site 745776003010 glycyl-tRNA synthetase; Provisional; Region: PRK04173 745776003011 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 745776003012 motif 1; other site 745776003013 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 745776003014 active site 745776003015 motif 2; other site 745776003016 motif 3; other site 745776003017 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 745776003018 anticodon binding site; other site 745776003019 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 745776003020 META domain; Region: META; pfam03724 745776003021 META domain; Region: META; pfam03724 745776003022 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 745776003023 B12 binding site [chemical binding]; other site 745776003024 cobalt ligand [ion binding]; other site 745776003025 Protein of unknown function (DUF402); Region: DUF402; cl00979 745776003026 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 745776003027 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 745776003028 S-adenosylmethionine synthetase; Validated; Region: PRK05250 745776003029 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 745776003030 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 745776003031 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 745776003032 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 745776003033 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 745776003034 active site 745776003035 (T/H)XGH motif; other site 745776003036 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 745776003037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745776003038 S-adenosylmethionine binding site [chemical binding]; other site 745776003039 Molybdopterin-guanine dinucleotide biosynthesis protein A [Coenzyme metabolism]; Region: MobA; COG0746 745776003040 hypothetical protein; Provisional; Region: PRK08201 745776003041 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 745776003042 metal binding site [ion binding]; metal-binding site 745776003043 putative dimer interface [polypeptide binding]; other site 745776003044 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 745776003045 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 745776003046 active site 745776003047 substrate binding site [chemical binding]; other site 745776003048 cosubstrate binding site; other site 745776003049 catalytic site [active] 745776003050 Protein of unknown function (DUF3809); Region: DUF3809; pfam12723 745776003051 Protein of unknown function (DUF3248); Region: DUF3248; pfam11609 745776003052 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 745776003053 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 745776003054 active site 745776003055 metal binding site [ion binding]; metal-binding site 745776003056 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 745776003057 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 745776003058 FAD binding domain; Region: FAD_binding_4; pfam01565 745776003059 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 745776003060 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 745776003061 Cysteine-rich domain; Region: CCG; pfam02754 745776003062 Cysteine-rich domain; Region: CCG; pfam02754 745776003063 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 745776003064 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 745776003065 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 745776003066 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 745776003067 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 745776003068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776003069 putative PBP binding loops; other site 745776003070 ABC-ATPase subunit interface; other site 745776003071 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 745776003072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776003073 dimer interface [polypeptide binding]; other site 745776003074 conserved gate region; other site 745776003075 putative PBP binding loops; other site 745776003076 ABC-ATPase subunit interface; other site 745776003077 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 745776003078 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 745776003079 Ligand Binding Site [chemical binding]; other site 745776003080 TIGR00269 family protein; Region: TIGR00269 745776003081 Transglycosylase; Region: Transgly; pfam00912 745776003082 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 745776003083 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 745776003084 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 745776003085 RNA/DNA hybrid binding site [nucleotide binding]; other site 745776003086 active site 745776003087 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 745776003088 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 745776003089 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 745776003090 ATP binding site [chemical binding]; other site 745776003091 putative Mg++ binding site [ion binding]; other site 745776003092 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 745776003093 nucleotide binding region [chemical binding]; other site 745776003094 ATP-binding site [chemical binding]; other site 745776003095 TRCF domain; Region: TRCF; pfam03461 745776003096 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 745776003097 Phosphotransferase enzyme family; Region: APH; pfam01636 745776003098 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 745776003099 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 745776003100 active site 745776003101 barstar interaction site; other site 745776003102 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 745776003103 putative RNAase interaction site [polypeptide binding]; other site 745776003104 UGMP family protein; Validated; Region: PRK09604 745776003105 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 745776003106 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 745776003107 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 745776003108 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 745776003109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776003110 ATP binding site [chemical binding]; other site 745776003111 Mg2+ binding site [ion binding]; other site 745776003112 G-X-G motif; other site 745776003113 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 745776003114 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 745776003115 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 745776003116 DNA binding residues [nucleotide binding] 745776003117 FUN14 family; Region: FUN14; cl01015 745776003118 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 745776003119 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 745776003120 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 745776003121 CHAD domain; Region: CHAD; pfam05235 745776003122 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 745776003123 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 745776003124 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 745776003125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776003126 dimer interface [polypeptide binding]; other site 745776003127 conserved gate region; other site 745776003128 putative PBP binding loops; other site 745776003129 ABC-ATPase subunit interface; other site 745776003130 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776003131 dimer interface [polypeptide binding]; other site 745776003132 conserved gate region; other site 745776003133 putative PBP binding loops; other site 745776003134 ABC-ATPase subunit interface; other site 745776003135 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 745776003136 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776003137 Walker A/P-loop; other site 745776003138 ATP binding site [chemical binding]; other site 745776003139 Q-loop/lid; other site 745776003140 ABC transporter signature motif; other site 745776003141 Walker B; other site 745776003142 D-loop; other site 745776003143 H-loop/switch region; other site 745776003144 TOBE domain; Region: TOBE_2; pfam08402 745776003145 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 745776003146 Cytochrome P450; Region: p450; cl12078 745776003147 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 745776003148 Predicted membrane protein [Function unknown]; Region: COG4270 745776003149 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 745776003150 active site 745776003151 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 745776003152 Peptidase family U32; Region: Peptidase_U32; pfam01136 745776003153 Collagenase; Region: DUF3656; pfam12392 745776003154 Peptidase family U32; Region: Peptidase_U32; cl03113 745776003155 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 745776003156 tetramerization interface [polypeptide binding]; other site 745776003157 active site 745776003158 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 745776003159 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 745776003160 Zn2+ binding site [ion binding]; other site 745776003161 Mg2+ binding site [ion binding]; other site 745776003162 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 745776003163 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 745776003164 putative substrate binding site [chemical binding]; other site 745776003165 putative ATP binding site [chemical binding]; other site 745776003166 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 745776003167 classical (c) SDRs; Region: SDR_c; cd05233 745776003168 NAD(P) binding site [chemical binding]; other site 745776003169 active site 745776003170 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 745776003171 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 745776003172 Thioredoxin; Region: Thioredoxin_4; pfam13462 745776003173 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 745776003174 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 745776003175 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 745776003176 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 745776003177 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 745776003178 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 745776003179 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 745776003180 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 745776003181 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 745776003182 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 745776003183 Zn2+ binding site [ion binding]; other site 745776003184 Mg2+ binding site [ion binding]; other site 745776003185 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 745776003186 synthetase active site [active] 745776003187 NTP binding site [chemical binding]; other site 745776003188 metal binding site [ion binding]; metal-binding site 745776003189 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 745776003190 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 745776003191 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 745776003192 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 745776003193 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 745776003194 dimerization interface [polypeptide binding]; other site 745776003195 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 745776003196 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 745776003197 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745776003198 S-adenosylmethionine binding site [chemical binding]; other site 745776003199 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745776003200 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 745776003201 substrate binding pocket [chemical binding]; other site 745776003202 membrane-bound complex binding site; other site 745776003203 hinge residues; other site 745776003204 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK14655 745776003205 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 745776003206 Mg++ binding site [ion binding]; other site 745776003207 putative catalytic motif [active] 745776003208 signal recognition particle protein; Provisional; Region: PRK10867 745776003209 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 745776003210 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 745776003211 P loop; other site 745776003212 GTP binding site [chemical binding]; other site 745776003213 Signal peptide binding domain; Region: SRP_SPB; pfam02978 745776003214 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 745776003215 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 745776003216 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 745776003217 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 745776003218 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 745776003219 Predicted transcriptional regulator [Transcription]; Region: COG2345 745776003220 Transcriptional regulator PadR-like family; Region: PadR; cl17335 745776003221 antiporter inner membrane protein; Provisional; Region: PRK11670 745776003222 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 745776003223 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 745776003224 GMP synthase; Reviewed; Region: guaA; PRK00074 745776003225 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 745776003226 AMP/PPi binding site [chemical binding]; other site 745776003227 candidate oxyanion hole; other site 745776003228 catalytic triad [active] 745776003229 potential glutamine specificity residues [chemical binding]; other site 745776003230 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 745776003231 ATP Binding subdomain [chemical binding]; other site 745776003232 Ligand Binding sites [chemical binding]; other site 745776003233 Dimerization subdomain; other site 745776003234 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 745776003235 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 745776003236 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 745776003237 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 745776003238 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 745776003239 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 745776003240 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 745776003241 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 745776003242 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 745776003243 ferredoxin-NADP+ reductase; Region: PLN02852 745776003244 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 745776003245 CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918 745776003246 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 745776003247 ligand binding site [chemical binding]; other site 745776003248 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 745776003249 putative switch regulator; other site 745776003250 non-specific DNA interactions [nucleotide binding]; other site 745776003251 DNA binding site [nucleotide binding] 745776003252 sequence specific DNA binding site [nucleotide binding]; other site 745776003253 putative cAMP binding site [chemical binding]; other site 745776003254 DNA gyrase subunit A; Validated; Region: PRK05560 745776003255 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 745776003256 CAP-like domain; other site 745776003257 active site 745776003258 primary dimer interface [polypeptide binding]; other site 745776003259 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 745776003260 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 745776003261 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 745776003262 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 745776003263 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 745776003264 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 745776003265 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 745776003266 PQQ-like domain; Region: PQQ_2; pfam13360 745776003267 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 745776003268 Trp docking motif [polypeptide binding]; other site 745776003269 active site 745776003270 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 745776003271 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 745776003272 Zn2+ binding site [ion binding]; other site 745776003273 Mg2+ binding site [ion binding]; other site 745776003274 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 745776003275 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 745776003276 active site 745776003277 homodimer interface [polypeptide binding]; other site 745776003278 catalytic site [active] 745776003279 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 745776003280 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 745776003281 Stage II sporulation protein; Region: SpoIID; pfam08486 745776003282 Beta-lactamase; Region: Beta-lactamase; cl17358 745776003283 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 745776003284 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 745776003285 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 745776003286 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 745776003287 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 745776003288 active site 745776003289 catalytic tetrad [active] 745776003290 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 745776003291 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 745776003292 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 745776003293 dimerization interface [polypeptide binding]; other site 745776003294 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745776003295 dimer interface [polypeptide binding]; other site 745776003296 phosphorylation site [posttranslational modification] 745776003297 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776003298 G-X-G motif; other site 745776003299 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 745776003300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776003301 active site 745776003302 phosphorylation site [posttranslational modification] 745776003303 intermolecular recognition site; other site 745776003304 dimerization interface [polypeptide binding]; other site 745776003305 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 745776003306 DNA binding site [nucleotide binding] 745776003307 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 745776003308 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 745776003309 P-loop; other site 745776003310 Magnesium ion binding site [ion binding]; other site 745776003311 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 745776003312 active site 745776003313 HIGH motif; other site 745776003314 nucleotide binding site [chemical binding]; other site 745776003315 active site 745776003316 KMSKS motif; other site 745776003317 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 745776003318 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 745776003319 kynureninase; Region: kynureninase; TIGR01814 745776003320 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 745776003321 catalytic residue [active] 745776003322 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 745776003323 catalytic core [active] 745776003324 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 745776003325 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 745776003326 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745776003327 catalytic residue [active] 745776003328 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 745776003329 substrate binding site [chemical binding]; other site 745776003330 active site 745776003331 catalytic residues [active] 745776003332 heterodimer interface [polypeptide binding]; other site 745776003333 sugar efflux transporter B; Provisional; Region: PRK15011 745776003334 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 745776003335 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 745776003336 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 745776003337 substrate binding site [chemical binding]; other site 745776003338 ligand binding site [chemical binding]; other site 745776003339 LysE type translocator; Region: LysE; cl00565 745776003340 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 745776003341 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 745776003342 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 745776003343 substrate binding site [chemical binding]; other site 745776003344 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 745776003345 tartrate dehydrogenase; Region: TTC; TIGR02089 745776003346 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 745776003347 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745776003348 DNA-binding site [nucleotide binding]; DNA binding site 745776003349 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 745776003350 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745776003351 homodimer interface [polypeptide binding]; other site 745776003352 catalytic residue [active] 745776003353 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 745776003354 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 745776003355 RNA binding surface [nucleotide binding]; other site 745776003356 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 745776003357 active site 745776003358 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 745776003359 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 745776003360 nudix motif; other site 745776003361 peptide chain release factor 1; Validated; Region: prfA; PRK00591 745776003362 PCRF domain; Region: PCRF; pfam03462 745776003363 RF-1 domain; Region: RF-1; pfam00472 745776003364 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 745776003365 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 745776003366 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 745776003367 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 745776003368 active site 745776003369 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 745776003370 catalytic tetrad [active] 745776003371 Methyltransferase domain; Region: Methyltransf_23; pfam13489 745776003372 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745776003373 S-adenosylmethionine binding site [chemical binding]; other site 745776003374 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 745776003375 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 745776003376 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 745776003377 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 745776003378 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 745776003379 DNA binding residues [nucleotide binding] 745776003380 MoxR-like ATPases [General function prediction only]; Region: COG0714 745776003381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745776003382 Walker A motif; other site 745776003383 ATP binding site [chemical binding]; other site 745776003384 Walker B motif; other site 745776003385 arginine finger; other site 745776003386 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 745776003387 Protein of unknown function DUF58; Region: DUF58; pfam01882 745776003388 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 745776003389 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 745776003390 trmE is a tRNA modification GTPase; Region: trmE; cd04164 745776003391 G1 box; other site 745776003392 GTP/Mg2+ binding site [chemical binding]; other site 745776003393 Switch I region; other site 745776003394 G2 box; other site 745776003395 Switch II region; other site 745776003396 G3 box; other site 745776003397 G4 box; other site 745776003398 G5 box; other site 745776003399 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 745776003400 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 745776003401 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 745776003402 ABC transporter; Region: ABC_tran; pfam00005 745776003403 Q-loop/lid; other site 745776003404 ABC transporter signature motif; other site 745776003405 Walker B; other site 745776003406 D-loop; other site 745776003407 H-loop/switch region; other site 745776003408 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 745776003409 E-class dimer interface [polypeptide binding]; other site 745776003410 P-class dimer interface [polypeptide binding]; other site 745776003411 active site 745776003412 Cu2+ binding site [ion binding]; other site 745776003413 Zn2+ binding site [ion binding]; other site 745776003414 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 745776003415 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 745776003416 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 745776003417 active site 745776003418 Riboflavin kinase; Region: Flavokinase; pfam01687 745776003419 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 745776003420 dimer interface [polypeptide binding]; other site 745776003421 ADP-ribose binding site [chemical binding]; other site 745776003422 active site 745776003423 nudix motif; other site 745776003424 metal binding site [ion binding]; metal-binding site 745776003425 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 745776003426 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 745776003427 Zn2+ binding site [ion binding]; other site 745776003428 Mg2+ binding site [ion binding]; other site 745776003429 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 745776003430 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 745776003431 DAK2 domain; Region: Dak2; pfam02734 745776003432 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 745776003433 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 745776003434 interface (dimer of trimers) [polypeptide binding]; other site 745776003435 Substrate-binding/catalytic site; other site 745776003436 Zn-binding sites [ion binding]; other site 745776003437 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 745776003438 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745776003439 metal binding site [ion binding]; metal-binding site 745776003440 active site 745776003441 I-site; other site 745776003442 GAF domain; Region: GAF; cl17456 745776003443 GAF domain; Region: GAF_2; pfam13185 745776003444 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 745776003445 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 745776003446 Zn2+ binding site [ion binding]; other site 745776003447 Mg2+ binding site [ion binding]; other site 745776003448 ParB-like nuclease domain; Region: ParBc; cl02129 745776003449 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 745776003450 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 745776003451 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 745776003452 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 745776003453 Moco binding site; other site 745776003454 metal coordination site [ion binding]; other site 745776003455 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 745776003456 active site 745776003457 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 745776003458 H+ Antiporter protein; Region: 2A0121; TIGR00900 745776003459 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 745776003460 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 745776003461 active site 745776003462 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 745776003463 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 745776003464 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 745776003465 metal binding site [ion binding]; metal-binding site 745776003466 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 745776003467 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 745776003468 substrate binding site [chemical binding]; other site 745776003469 glutamase interaction surface [polypeptide binding]; other site 745776003470 Response regulator receiver domain; Region: Response_reg; pfam00072 745776003471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776003472 active site 745776003473 phosphorylation site [posttranslational modification] 745776003474 intermolecular recognition site; other site 745776003475 dimerization interface [polypeptide binding]; other site 745776003476 Uncharacterized conserved protein [Function unknown]; Region: COG1801 745776003477 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 745776003478 tartrate dehydrogenase; Region: TTC; TIGR02089 745776003479 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 745776003480 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 745776003481 PRC-barrel domain; Region: PRC; pfam05239 745776003482 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 745776003483 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 745776003484 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 745776003485 tetramer interface [polypeptide binding]; other site 745776003486 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745776003487 catalytic residue [active] 745776003488 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 745776003489 Ubiquitin-like proteins; Region: UBQ; cl00155 745776003490 CAAX protease self-immunity; Region: Abi; pfam02517 745776003491 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 745776003492 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 745776003493 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 745776003494 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 745776003495 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 745776003496 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 745776003497 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 745776003498 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 745776003499 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 745776003500 DNA binding site [nucleotide binding] 745776003501 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 745776003502 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 745776003503 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 745776003504 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 745776003505 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 745776003506 RPB10 interaction site [polypeptide binding]; other site 745776003507 RPB1 interaction site [polypeptide binding]; other site 745776003508 RPB11 interaction site [polypeptide binding]; other site 745776003509 RPB3 interaction site [polypeptide binding]; other site 745776003510 RPB12 interaction site [polypeptide binding]; other site 745776003511 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 745776003512 DNA-binding site [nucleotide binding]; DNA binding site 745776003513 RNA-binding motif; other site 745776003514 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 745776003515 peripheral dimer interface [polypeptide binding]; other site 745776003516 core dimer interface [polypeptide binding]; other site 745776003517 L10 interface [polypeptide binding]; other site 745776003518 L11 interface [polypeptide binding]; other site 745776003519 putative EF-Tu interaction site [polypeptide binding]; other site 745776003520 putative EF-G interaction site [polypeptide binding]; other site 745776003521 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 745776003522 23S rRNA interface [nucleotide binding]; other site 745776003523 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 745776003524 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 745776003525 mRNA/rRNA interface [nucleotide binding]; other site 745776003526 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 745776003527 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 745776003528 23S rRNA interface [nucleotide binding]; other site 745776003529 L7/L12 interface [polypeptide binding]; other site 745776003530 putative thiostrepton binding site; other site 745776003531 L25 interface [polypeptide binding]; other site 745776003532 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 745776003533 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 745776003534 putative homodimer interface [polypeptide binding]; other site 745776003535 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 745776003536 heterodimer interface [polypeptide binding]; other site 745776003537 homodimer interface [polypeptide binding]; other site 745776003538 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 745776003539 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 745776003540 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 745776003541 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 745776003542 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776003543 Walker A/P-loop; other site 745776003544 ATP binding site [chemical binding]; other site 745776003545 Q-loop/lid; other site 745776003546 ABC transporter signature motif; other site 745776003547 Walker B; other site 745776003548 D-loop; other site 745776003549 H-loop/switch region; other site 745776003550 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 745776003551 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 745776003552 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 745776003553 Walker A/P-loop; other site 745776003554 ATP binding site [chemical binding]; other site 745776003555 Q-loop/lid; other site 745776003556 ABC transporter signature motif; other site 745776003557 Walker B; other site 745776003558 D-loop; other site 745776003559 H-loop/switch region; other site 745776003560 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 745776003561 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 745776003562 putative ligand binding site [chemical binding]; other site 745776003563 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 745776003564 TM-ABC transporter signature motif; other site 745776003565 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 745776003566 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 745776003567 TM-ABC transporter signature motif; other site 745776003568 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 745776003569 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 745776003570 Walker A/P-loop; other site 745776003571 ATP binding site [chemical binding]; other site 745776003572 Q-loop/lid; other site 745776003573 ABC transporter signature motif; other site 745776003574 Walker B; other site 745776003575 D-loop; other site 745776003576 H-loop/switch region; other site 745776003577 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 745776003578 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 745776003579 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 745776003580 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776003581 dimer interface [polypeptide binding]; other site 745776003582 conserved gate region; other site 745776003583 putative PBP binding loops; other site 745776003584 ABC-ATPase subunit interface; other site 745776003585 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 745776003586 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776003587 dimer interface [polypeptide binding]; other site 745776003588 conserved gate region; other site 745776003589 putative PBP binding loops; other site 745776003590 ABC-ATPase subunit interface; other site 745776003591 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14272 745776003592 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 745776003593 Walker A/P-loop; other site 745776003594 ATP binding site [chemical binding]; other site 745776003595 Q-loop/lid; other site 745776003596 ABC transporter signature motif; other site 745776003597 Walker B; other site 745776003598 D-loop; other site 745776003599 H-loop/switch region; other site 745776003600 PhoU domain; Region: PhoU; pfam01895 745776003601 Phosphate uptake regulator [Inorganic ion transport and metabolism]; Region: PhoU; COG0704 745776003602 PhoU domain; Region: PhoU; pfam01895 745776003603 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 745776003604 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 745776003605 active site 745776003606 Zn binding site [ion binding]; other site 745776003607 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 745776003608 tandem repeat interface [polypeptide binding]; other site 745776003609 oligomer interface [polypeptide binding]; other site 745776003610 active site residues [active] 745776003611 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 745776003612 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 745776003613 tandem repeat interface [polypeptide binding]; other site 745776003614 oligomer interface [polypeptide binding]; other site 745776003615 active site residues [active] 745776003616 Cytochrome c; Region: Cytochrom_C; pfam00034 745776003617 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 745776003618 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 745776003619 classical (c) SDRs; Region: SDR_c; cd05233 745776003620 NAD(P) binding site [chemical binding]; other site 745776003621 active site 745776003622 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 745776003623 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 745776003624 putative NAD(P) binding site [chemical binding]; other site 745776003625 putative substrate binding site [chemical binding]; other site 745776003626 catalytic Zn binding site [ion binding]; other site 745776003627 structural Zn binding site [ion binding]; other site 745776003628 Transcriptional regulator; Region: Rrf2; cl17282 745776003629 Rrf2 family protein; Region: rrf2_super; TIGR00738 745776003630 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 745776003631 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 745776003632 quinone interaction residues [chemical binding]; other site 745776003633 active site 745776003634 catalytic residues [active] 745776003635 FMN binding site [chemical binding]; other site 745776003636 substrate binding site [chemical binding]; other site 745776003637 Protein of unknown function (DUF805); Region: DUF805; pfam05656 745776003638 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 745776003639 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 745776003640 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 745776003641 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 745776003642 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 745776003643 active site 745776003644 dimer interface [polypeptide binding]; other site 745776003645 motif 1; other site 745776003646 motif 2; other site 745776003647 motif 3; other site 745776003648 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 745776003649 anticodon binding site; other site 745776003650 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 745776003651 Fasciclin domain; Region: Fasciclin; pfam02469 745776003652 Fasciclin domain; Region: Fasciclin; pfam02469 745776003653 Fasciclin domain; Region: Fasciclin; pfam02469 745776003654 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 745776003655 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 745776003656 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 745776003657 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 745776003658 MPN+ (JAMM) motif; other site 745776003659 Zinc-binding site [ion binding]; other site 745776003660 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 745776003661 active site 745776003662 tetramer interface [polypeptide binding]; other site 745776003663 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 745776003664 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 745776003665 ligand binding site [chemical binding]; other site 745776003666 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 745776003667 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 745776003668 nucleotide binding pocket [chemical binding]; other site 745776003669 K-X-D-G motif; other site 745776003670 catalytic site [active] 745776003671 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 745776003672 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 745776003673 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 745776003674 Dimer interface [polypeptide binding]; other site 745776003675 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 745776003676 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 745776003677 Divergent PAP2 family; Region: DUF212; pfam02681 745776003678 NADH-quinone oxidoreductase chain 15; Region: NADH_Oxid_Nqo15; pfam11497 745776003679 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 745776003680 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 745776003681 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 745776003682 active site 745776003683 homodimer interface [polypeptide binding]; other site 745776003684 catalytic site [active] 745776003685 Protein of unknown function (DUF402); Region: DUF402; cl00979 745776003686 Acyltransferase family; Region: Acyl_transf_3; pfam01757 745776003687 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 745776003688 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745776003689 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 745776003690 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 745776003691 DNA binding residues [nucleotide binding] 745776003692 dimerization interface [polypeptide binding]; other site 745776003693 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 745776003694 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 745776003695 Helix-turn-helix domain; Region: HTH_17; pfam12728 745776003696 Uncharacterized conserved protein [Function unknown]; Region: COG3603 745776003697 Family description; Region: ACT_7; pfam13840 745776003698 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 745776003699 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 745776003700 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 745776003701 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 745776003702 FMN binding site [chemical binding]; other site 745776003703 substrate binding site [chemical binding]; other site 745776003704 putative catalytic residue [active] 745776003705 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 745776003706 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 745776003707 putative active site [active] 745776003708 Zn binding site [ion binding]; other site 745776003709 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 745776003710 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 745776003711 Switch I region; other site 745776003712 G2 box; other site 745776003713 putative GEF interaction site [polypeptide binding]; other site 745776003714 G3 box; other site 745776003715 Switch II region; other site 745776003716 GTP/Mg2+ binding site [chemical binding]; other site 745776003717 G4 box; other site 745776003718 G5 box; other site 745776003719 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 745776003720 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 745776003721 putative active site [active] 745776003722 Uncharacterized conserved protein [Function unknown]; Region: COG4278 745776003723 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 745776003724 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 745776003725 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 745776003726 protein binding site [polypeptide binding]; other site 745776003727 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 745776003728 Catalytic dyad [active] 745776003729 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 745776003730 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776003731 Walker A/P-loop; other site 745776003732 ATP binding site [chemical binding]; other site 745776003733 Q-loop/lid; other site 745776003734 ABC transporter signature motif; other site 745776003735 Walker B; other site 745776003736 D-loop; other site 745776003737 H-loop/switch region; other site 745776003738 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 745776003739 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 745776003740 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 745776003741 Peptidase family M23; Region: Peptidase_M23; pfam01551 745776003742 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 745776003743 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 745776003744 MPT binding site; other site 745776003745 trimer interface [polypeptide binding]; other site 745776003746 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 745776003747 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 745776003748 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 745776003749 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 745776003750 putative acyltransferase; Provisional; Region: PRK05790 745776003751 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 745776003752 dimer interface [polypeptide binding]; other site 745776003753 active site 745776003754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 745776003755 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 745776003756 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 745776003757 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 745776003758 putative substrate binding site [chemical binding]; other site 745776003759 putative ATP binding site [chemical binding]; other site 745776003760 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 745776003761 binding surface 745776003762 TPR motif; other site 745776003763 Tetratricopeptide repeat; Region: TPR_16; pfam13432 745776003764 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 745776003765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745776003766 S-adenosylmethionine binding site [chemical binding]; other site 745776003767 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 745776003768 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 745776003769 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 745776003770 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 745776003771 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 745776003772 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 745776003773 active site 745776003774 metal binding site [ion binding]; metal-binding site 745776003775 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 745776003776 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 745776003777 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 745776003778 nucleotide binding region [chemical binding]; other site 745776003779 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 745776003780 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 745776003781 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 745776003782 catalytic residue [active] 745776003783 GTP-binding protein YchF; Reviewed; Region: PRK09601 745776003784 YchF GTPase; Region: YchF; cd01900 745776003785 Switch II region; other site 745776003786 G3 box; other site 745776003787 GTP/Mg2+ binding site [chemical binding]; other site 745776003788 G4 box; other site 745776003789 G5 box; other site 745776003790 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 745776003791 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 745776003792 heme binding pocket [chemical binding]; other site 745776003793 heme ligand [chemical binding]; other site 745776003794 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 745776003795 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 745776003796 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 745776003797 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 745776003798 Predicted membrane protein [Function unknown]; Region: COG1470 745776003799 futalosine nucleosidase; Region: fut_nucase; TIGR03664 745776003800 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 745776003801 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 745776003802 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 745776003803 TrkA-N domain; Region: TrkA_N; pfam02254 745776003804 TrkA-C domain; Region: TrkA_C; pfam02080 745776003805 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 745776003806 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 745776003807 Methyltransferase domain; Region: Methyltransf_31; pfam13847 745776003808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745776003809 S-adenosylmethionine binding site [chemical binding]; other site 745776003810 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 745776003811 Haemolytic domain; Region: Haemolytic; cl00506 745776003812 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 745776003813 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 745776003814 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 745776003815 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 745776003816 substrate binding pocket [chemical binding]; other site 745776003817 chain length determination region; other site 745776003818 substrate-Mg2+ binding site; other site 745776003819 catalytic residues [active] 745776003820 aspartate-rich region 1; other site 745776003821 active site lid residues [active] 745776003822 aspartate-rich region 2; other site 745776003823 acylphosphatase; Provisional; Region: PRK14433 745776003824 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 745776003825 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 745776003826 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 745776003827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745776003828 Major Facilitator Superfamily; Region: MFS_1; pfam07690 745776003829 putative substrate translocation pore; other site 745776003830 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 745776003831 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 745776003832 NADH dehydrogenase subunit B; Validated; Region: PRK06411 745776003833 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 745776003834 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 745776003835 NADH dehydrogenase subunit D; Validated; Region: PRK06075 745776003836 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958 745776003837 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 745776003838 putative dimer interface [polypeptide binding]; other site 745776003839 [2Fe-2S] cluster binding site [ion binding]; other site 745776003840 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 745776003841 SLBB domain; Region: SLBB; pfam10531 745776003842 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 745776003843 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 745776003844 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 745776003845 catalytic loop [active] 745776003846 iron binding site [ion binding]; other site 745776003847 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 745776003848 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 745776003849 molybdopterin cofactor binding site; other site 745776003850 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 745776003851 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 745776003852 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143 745776003853 4Fe-4S binding domain; Region: Fer4; pfam00037 745776003854 4Fe-4S binding domain; Region: Fer4; pfam00037 745776003855 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 745776003856 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 745776003857 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 745776003858 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 745776003859 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 745776003860 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 745776003861 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 745776003862 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 745776003863 proton-translocating NADH-quinone oxidoreductase, chain N; Region: NDH_I_N; TIGR01770 745776003864 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 745776003865 CHASE2 domain; Region: CHASE2; pfam05226 745776003866 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 745776003867 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745776003868 metal binding site [ion binding]; metal-binding site 745776003869 active site 745776003870 I-site; other site 745776003871 FecR protein; Region: FecR; pfam04773 745776003872 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 745776003873 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776003874 Walker A/P-loop; other site 745776003875 ATP binding site [chemical binding]; other site 745776003876 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 745776003877 ABC transporter signature motif; other site 745776003878 Walker B; other site 745776003879 D-loop; other site 745776003880 ABC transporter; Region: ABC_tran_2; pfam12848 745776003881 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 745776003882 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 745776003883 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 745776003884 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 745776003885 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 745776003886 seryl-tRNA synthetase; Provisional; Region: PRK05431 745776003887 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 745776003888 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 745776003889 dimer interface [polypeptide binding]; other site 745776003890 active site 745776003891 motif 1; other site 745776003892 motif 2; other site 745776003893 motif 3; other site 745776003894 PAS domain; Region: PAS_9; pfam13426 745776003895 GAF domain; Region: GAF_3; pfam13492 745776003896 GAF domain; Region: GAF_2; pfam13185 745776003897 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745776003898 dimer interface [polypeptide binding]; other site 745776003899 phosphorylation site [posttranslational modification] 745776003900 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776003901 ATP binding site [chemical binding]; other site 745776003902 Mg2+ binding site [ion binding]; other site 745776003903 G-X-G motif; other site 745776003904 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 745776003905 Domain of unknown function DUF21; Region: DUF21; pfam01595 745776003906 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 745776003907 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 745776003908 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 745776003909 active site 745776003910 catalytic motif [active] 745776003911 Zn binding site [ion binding]; other site 745776003912 isocitrate lyase; Provisional; Region: PRK15063 745776003913 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 745776003914 tetramer interface [polypeptide binding]; other site 745776003915 active site 745776003916 Mg2+/Mn2+ binding site [ion binding]; other site 745776003917 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 745776003918 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745776003919 motif II; other site 745776003920 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 745776003921 DHH family; Region: DHH; pfam01368 745776003922 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 745776003923 EDD domain protein, DegV family; Region: DegV; TIGR00762 745776003924 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 745776003925 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 745776003926 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 745776003927 4Fe-4S binding domain; Region: Fer4; cl02805 745776003928 Cysteine-rich domain; Region: CCG; pfam02754 745776003929 Cysteine-rich domain; Region: CCG; pfam02754 745776003930 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 745776003931 Uncharacterized conserved protein [Function unknown]; Region: COG2127 745776003932 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 745776003933 Clp amino terminal domain; Region: Clp_N; pfam02861 745776003934 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745776003935 Walker A motif; other site 745776003936 ATP binding site [chemical binding]; other site 745776003937 Walker B motif; other site 745776003938 arginine finger; other site 745776003939 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745776003940 Walker A motif; other site 745776003941 ATP binding site [chemical binding]; other site 745776003942 Walker B motif; other site 745776003943 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 745776003944 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 745776003945 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 745776003946 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 745776003947 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 745776003948 oxidoreductase; Provisional; Region: PRK06128 745776003949 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745776003950 NAD(P) binding site [chemical binding]; other site 745776003951 active site 745776003952 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 745776003953 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 745776003954 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 745776003955 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 745776003956 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 745776003957 putative active site [active] 745776003958 putative substrate binding site [chemical binding]; other site 745776003959 putative cosubstrate binding site; other site 745776003960 catalytic site [active] 745776003961 Erythromycin esterase; Region: Erythro_esteras; cl17110 745776003962 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 745776003963 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 745776003964 dimer interface [polypeptide binding]; other site 745776003965 metal binding site [ion binding]; metal-binding site 745776003966 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 745776003967 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 745776003968 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 745776003969 PhoH-like protein; Region: PhoH; pfam02562 745776003970 Predicted dehydrogenase [General function prediction only]; Region: COG5322 745776003971 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 745776003972 NAD(P) binding pocket [chemical binding]; other site 745776003973 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 745776003974 nudix motif; other site 745776003975 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 745776003976 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 745776003977 dimer interface [polypeptide binding]; other site 745776003978 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745776003979 catalytic residue [active] 745776003980 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 745776003981 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 745776003982 tetramer interface [polypeptide binding]; other site 745776003983 active site 745776003984 Mg2+/Mn2+ binding site [ion binding]; other site 745776003985 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 745776003986 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 745776003987 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 745776003988 minor groove reading motif; other site 745776003989 endonuclease III; Region: ENDO3c; smart00478 745776003990 helix-hairpin-helix signature motif; other site 745776003991 substrate binding pocket [chemical binding]; other site 745776003992 active site 745776003993 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 745776003994 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 745776003995 active site 745776003996 metal binding site [ion binding]; metal-binding site 745776003997 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 745776003998 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 745776003999 B12 binding site [chemical binding]; other site 745776004000 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 745776004001 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 745776004002 FeS/SAM binding site; other site 745776004003 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 745776004004 MOFRL family; Region: MOFRL; pfam05161 745776004005 Response regulator receiver domain; Region: Response_reg; pfam00072 745776004006 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776004007 active site 745776004008 phosphorylation site [posttranslational modification] 745776004009 intermolecular recognition site; other site 745776004010 dimerization interface [polypeptide binding]; other site 745776004011 Response regulator receiver domain; Region: Response_reg; pfam00072 745776004012 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776004013 active site 745776004014 phosphorylation site [posttranslational modification] 745776004015 intermolecular recognition site; other site 745776004016 dimerization interface [polypeptide binding]; other site 745776004017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776004018 Response regulator receiver domain; Region: Response_reg; pfam00072 745776004019 active site 745776004020 phosphorylation site [posttranslational modification] 745776004021 intermolecular recognition site; other site 745776004022 dimerization interface [polypeptide binding]; other site 745776004023 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 745776004024 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 745776004025 substrate binding site [chemical binding]; other site 745776004026 ligand binding site [chemical binding]; other site 745776004027 homoaconitate hydratase small subunit; Provisional; Region: PRK14023 745776004028 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 745776004029 substrate binding site [chemical binding]; other site 745776004030 Protein of unknown function (DUF1517); Region: DUF1517; cl01807 745776004031 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 745776004032 Nuclease-related domain; Region: NERD; pfam08378 745776004033 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 745776004034 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 745776004035 catalytic residue [active] 745776004036 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 745776004037 PAS domain; Region: PAS_9; pfam13426 745776004038 putative active site [active] 745776004039 heme pocket [chemical binding]; other site 745776004040 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 745776004041 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 745776004042 Zn2+ binding site [ion binding]; other site 745776004043 Mg2+ binding site [ion binding]; other site 745776004044 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 745776004045 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 745776004046 Ligand Binding Site [chemical binding]; other site 745776004047 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 745776004048 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745776004049 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 745776004050 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 745776004051 short chain dehydrogenase; Provisional; Region: PRK06181 745776004052 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745776004053 NAD(P) binding site [chemical binding]; other site 745776004054 active site 745776004055 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 745776004056 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 745776004057 generic binding surface II; other site 745776004058 ssDNA binding site; other site 745776004059 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 745776004060 ATP binding site [chemical binding]; other site 745776004061 putative Mg++ binding site [ion binding]; other site 745776004062 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 745776004063 nucleotide binding region [chemical binding]; other site 745776004064 ATP-binding site [chemical binding]; other site 745776004065 calcium/proton exchanger (cax); Region: cax; TIGR00378 745776004066 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 745776004067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745776004068 putative substrate translocation pore; other site 745776004069 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 745776004070 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 745776004071 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 745776004072 4Fe-4S binding domain; Region: Fer4_6; pfam12837 745776004073 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 745776004074 [4Fe-4S] binding site [ion binding]; other site 745776004075 molybdopterin cofactor binding site; other site 745776004076 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 745776004077 molybdopterin cofactor binding site; other site 745776004078 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 745776004079 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 745776004080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745776004081 putative substrate translocation pore; other site 745776004082 acyl-coenzyme A oxidase; Region: PLN02526 745776004083 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 745776004084 active site 745776004085 acetylornithine aminotransferase; Provisional; Region: PRK02627 745776004086 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 745776004087 inhibitor-cofactor binding pocket; inhibition site 745776004088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745776004089 catalytic residue [active] 745776004090 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 745776004091 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 745776004092 nudix motif; other site 745776004093 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 745776004094 heterotetramer interface [polypeptide binding]; other site 745776004095 active site pocket [active] 745776004096 cleavage site 745776004097 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 745776004098 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 745776004099 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 745776004100 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 745776004101 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 745776004102 nucleotide binding site/active site [active] 745776004103 HIT family signature motif; other site 745776004104 catalytic residue [active] 745776004105 Melibiase; Region: Melibiase; pfam02065 745776004106 alpha-galactosidase; Provisional; Region: PRK15076 745776004107 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 745776004108 NAD binding site [chemical binding]; other site 745776004109 sugar binding site [chemical binding]; other site 745776004110 divalent metal binding site [ion binding]; other site 745776004111 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 745776004112 dimer interface [polypeptide binding]; other site 745776004113 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 745776004114 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 745776004115 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 745776004116 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 745776004117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776004118 dimer interface [polypeptide binding]; other site 745776004119 conserved gate region; other site 745776004120 putative PBP binding loops; other site 745776004121 ABC-ATPase subunit interface; other site 745776004122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776004123 dimer interface [polypeptide binding]; other site 745776004124 conserved gate region; other site 745776004125 putative PBP binding loops; other site 745776004126 ABC-ATPase subunit interface; other site 745776004127 Transcriptional regulators [Transcription]; Region: PurR; COG1609 745776004128 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745776004129 DNA binding site [nucleotide binding] 745776004130 domain linker motif; other site 745776004131 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 745776004132 ligand binding site [chemical binding]; other site 745776004133 dimerization interface [polypeptide binding]; other site 745776004134 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 745776004135 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 745776004136 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 745776004137 Protein of unknown function (DUF970); Region: DUF970; pfam06153 745776004138 adenylosuccinate lyase; Provisional; Region: PRK07492 745776004139 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 745776004140 tetramer interface [polypeptide binding]; other site 745776004141 active site 745776004142 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 745776004143 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 745776004144 active site 745776004145 catalytic tetrad [active] 745776004146 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 745776004147 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 745776004148 active site 745776004149 dimerization interface [polypeptide binding]; other site 745776004150 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 745776004151 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 745776004152 putative active site [active] 745776004153 Zn binding site [ion binding]; other site 745776004154 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 745776004155 CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918 745776004156 ligand binding site [chemical binding]; other site 745776004157 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 745776004158 putative switch regulator; other site 745776004159 non-specific DNA interactions [nucleotide binding]; other site 745776004160 DNA binding site [nucleotide binding] 745776004161 sequence specific DNA binding site [nucleotide binding]; other site 745776004162 putative cAMP binding site [chemical binding]; other site 745776004163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2380 745776004164 HerA helicase [Replication, recombination, and repair]; Region: COG0433 745776004165 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 745776004166 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 745776004167 NlpC/P60 family; Region: NLPC_P60; pfam00877 745776004168 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 745776004169 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 745776004170 Fe-S cluster binding site [ion binding]; other site 745776004171 active site 745776004172 Domain of unknown function (DUF1844); Region: DUF1844; pfam08899 745776004173 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 745776004174 putative active site [active] 745776004175 dimerization interface [polypeptide binding]; other site 745776004176 putative tRNAtyr binding site [nucleotide binding]; other site 745776004177 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 745776004178 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 745776004179 Peptidase family M23; Region: Peptidase_M23; pfam01551 745776004180 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 745776004181 CoenzymeA binding site [chemical binding]; other site 745776004182 subunit interaction site [polypeptide binding]; other site 745776004183 PHB binding site; other site 745776004184 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 745776004185 catalytic triad [active] 745776004186 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 745776004187 tetramer (dimer of dimers) interface [polypeptide binding]; other site 745776004188 active site 745776004189 dimer interface [polypeptide binding]; other site 745776004190 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 745776004191 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 745776004192 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 745776004193 Protein export membrane protein; Region: SecD_SecF; pfam02355 745776004194 Sm and related proteins; Region: Sm_like; cl00259 745776004195 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 745776004196 transcription termination factor NusA; Region: NusA; TIGR01953 745776004197 NusA N-terminal domain; Region: NusA_N; pfam08529 745776004198 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 745776004199 RNA binding site [nucleotide binding]; other site 745776004200 homodimer interface [polypeptide binding]; other site 745776004201 NusA-like KH domain; Region: KH_5; pfam13184 745776004202 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 745776004203 G-X-X-G motif; other site 745776004204 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 745776004205 putative RNA binding cleft [nucleotide binding]; other site 745776004206 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 745776004207 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 745776004208 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 745776004209 G1 box; other site 745776004210 putative GEF interaction site [polypeptide binding]; other site 745776004211 GTP/Mg2+ binding site [chemical binding]; other site 745776004212 Switch I region; other site 745776004213 G2 box; other site 745776004214 G3 box; other site 745776004215 Switch II region; other site 745776004216 G4 box; other site 745776004217 G5 box; other site 745776004218 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 745776004219 Translation-initiation factor 2; Region: IF-2; pfam11987 745776004220 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 745776004221 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 745776004222 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 745776004223 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 745776004224 RNA binding site [nucleotide binding]; other site 745776004225 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 745776004226 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 745776004227 protein binding site [polypeptide binding]; other site 745776004228 DinB superfamily; Region: DinB_2; pfam12867 745776004229 AAK_NAGK-UC: N-Acetyl-L-glutamate kinase - uncharacterized (NAGK-UC). This domain is similar to Escherichia coli and Pseudomonas aeruginosa NAGKs which catalyze the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the...; Region: AAK_NAGK-UC; cd04251 745776004230 putative nucleotide binding site [chemical binding]; other site 745776004231 putative N-acetyl-L-glutamate binding site [chemical binding]; other site 745776004232 Response regulator receiver domain; Region: Response_reg; pfam00072 745776004233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776004234 active site 745776004235 phosphorylation site [posttranslational modification] 745776004236 intermolecular recognition site; other site 745776004237 dimerization interface [polypeptide binding]; other site 745776004238 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 745776004239 Transglycosylase; Region: Transgly; pfam00912 745776004240 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 745776004241 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 745776004242 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 745776004243 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 745776004244 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 745776004245 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 745776004246 active site 745776004247 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 745776004248 dimer interface [polypeptide binding]; other site 745776004249 active site 745776004250 Schiff base residues; other site 745776004251 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 745776004252 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 745776004253 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 745776004254 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 745776004255 catalytic loop [active] 745776004256 iron binding site [ion binding]; other site 745776004257 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 745776004258 L-aspartate oxidase; Provisional; Region: PRK06175 745776004259 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 745776004260 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 745776004261 putative Iron-sulfur protein interface [polypeptide binding]; other site 745776004262 putative proximal heme binding site [chemical binding]; other site 745776004263 putative SdhC-like subunit interface [polypeptide binding]; other site 745776004264 putative distal heme binding site [chemical binding]; other site 745776004265 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 745776004266 putative Iron-sulfur protein interface [polypeptide binding]; other site 745776004267 putative proximal heme binding site [chemical binding]; other site 745776004268 putative SdhD-like interface [polypeptide binding]; other site 745776004269 putative distal heme binding site [chemical binding]; other site 745776004270 PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393 745776004271 active site 745776004272 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 745776004273 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 745776004274 Walker A/P-loop; other site 745776004275 ATP binding site [chemical binding]; other site 745776004276 Q-loop/lid; other site 745776004277 ABC transporter signature motif; other site 745776004278 Walker B; other site 745776004279 D-loop; other site 745776004280 H-loop/switch region; other site 745776004281 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 745776004282 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 745776004283 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 745776004284 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 745776004285 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 745776004286 Surface antigen; Region: Bac_surface_Ag; pfam01103 745776004287 Thioredoxin; Region: Thioredoxin_4; cl17273 745776004288 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 745776004289 catalytic residues [active] 745776004290 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 745776004291 Domain of unknown function (DUF814); Region: DUF814; pfam05670 745776004292 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 745776004293 active site residue [active] 745776004294 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 745776004295 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 745776004296 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 745776004297 catalytic triad [active] 745776004298 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 745776004299 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 745776004300 Ligand Binding Site [chemical binding]; other site 745776004301 TilS substrate C-terminal domain; Region: TilS_C; smart00977 745776004302 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 745776004303 nucleoside/Zn binding site; other site 745776004304 dimer interface [polypeptide binding]; other site 745776004305 catalytic motif [active] 745776004306 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 745776004307 active site 745776004308 dimer interface [polypeptide binding]; other site 745776004309 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 745776004310 intersubunit interface [polypeptide binding]; other site 745776004311 active site 745776004312 catalytic residue [active] 745776004313 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 745776004314 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 745776004315 G1 box; other site 745776004316 putative GEF interaction site [polypeptide binding]; other site 745776004317 GTP/Mg2+ binding site [chemical binding]; other site 745776004318 Switch I region; other site 745776004319 G2 box; other site 745776004320 G3 box; other site 745776004321 Switch II region; other site 745776004322 G4 box; other site 745776004323 G5 box; other site 745776004324 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 745776004325 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 745776004326 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 745776004327 Methyltransferase domain; Region: Methyltransf_23; pfam13489 745776004328 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745776004329 S-adenosylmethionine binding site [chemical binding]; other site 745776004330 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 745776004331 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 745776004332 Coenzyme A binding pocket [chemical binding]; other site 745776004333 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 745776004334 active site 745776004335 catalytic triad [active] 745776004336 Protein of unknown function (DUF1999); Region: DUF1999; pfam09390 745776004337 metal-binding site [ion binding] 745776004338 Heavy-metal-associated domain; Region: HMA; pfam00403 745776004339 Protein of unknown function (DUF503); Region: DUF503; cl00669 745776004340 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 745776004341 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 745776004342 Catalytic site [active] 745776004343 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 745776004344 Saccharomyces cerevisiae homocitrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_HCS; cd07948 745776004345 homocitrate synthase; Region: LysS_fung_arch; TIGR02146 745776004346 active site 745776004347 catalytic residues [active] 745776004348 metal binding site [ion binding]; metal-binding site 745776004349 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 745776004350 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 745776004351 active site 745776004352 catalytic tetrad [active] 745776004353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 745776004354 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 745776004355 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 745776004356 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 745776004357 ligand binding site [chemical binding]; other site 745776004358 flexible hinge region; other site 745776004359 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 745776004360 non-specific DNA interactions [nucleotide binding]; other site 745776004361 DNA binding site [nucleotide binding] 745776004362 sequence specific DNA binding site [nucleotide binding]; other site 745776004363 putative cAMP binding site [chemical binding]; other site 745776004364 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 745776004365 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 745776004366 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 745776004367 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 745776004368 inhibitor-cofactor binding pocket; inhibition site 745776004369 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745776004370 catalytic residue [active] 745776004371 Protein of unknown function (DUF664); Region: DUF664; pfam04978 745776004372 DinB superfamily; Region: DinB_2; pfam12867 745776004373 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 745776004374 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 745776004375 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 745776004376 Glutamate binding site [chemical binding]; other site 745776004377 homodimer interface [polypeptide binding]; other site 745776004378 NAD binding site [chemical binding]; other site 745776004379 catalytic residues [active] 745776004380 N-acetylmannosamine kinase; Provisional; Region: PRK05082 745776004381 Protein of unknown function (DUF4127); Region: DUF4127; pfam13552 745776004382 esterase; Provisional; Region: PRK10566 745776004383 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 745776004384 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 745776004385 nudix motif; other site 745776004386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776004387 dimer interface [polypeptide binding]; other site 745776004388 conserved gate region; other site 745776004389 putative PBP binding loops; other site 745776004390 ABC-ATPase subunit interface; other site 745776004391 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 745776004392 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 745776004393 ATP binding site [chemical binding]; other site 745776004394 putative Mg++ binding site [ion binding]; other site 745776004395 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 745776004396 nucleotide binding region [chemical binding]; other site 745776004397 ATP-binding site [chemical binding]; other site 745776004398 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 745776004399 dimer interface [polypeptide binding]; other site 745776004400 FMN binding site [chemical binding]; other site 745776004401 NADPH bind site [chemical binding]; other site 745776004402 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 745776004403 DNA polymerase I; Region: pola; TIGR00593 745776004404 active site 745776004405 putative 5' ssDNA interaction site; other site 745776004406 metal binding site 3; metal-binding site 745776004407 metal binding site 1 [ion binding]; metal-binding site 745776004408 metal binding site 2 [ion binding]; metal-binding site 745776004409 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 745776004410 putative DNA binding site [nucleotide binding]; other site 745776004411 putative metal binding site [ion binding]; other site 745776004412 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 745776004413 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 745776004414 active site 745776004415 DNA binding site [nucleotide binding] 745776004416 catalytic site [active] 745776004417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719 745776004418 Predicted transcriptional regulators [Transcription]; Region: COG1733 745776004419 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 745776004420 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 745776004421 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 745776004422 homodimer interface [polypeptide binding]; other site 745776004423 substrate-cofactor binding pocket; other site 745776004424 catalytic residue [active] 745776004425 glycogen branching enzyme; Provisional; Region: PRK14706 745776004426 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 745776004427 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 745776004428 active site 745776004429 catalytic site [active] 745776004430 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 745776004431 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 745776004432 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 745776004433 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 745776004434 Glutamine amidotransferase class-I; Region: GATase; pfam00117 745776004435 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 745776004436 glutamine binding [chemical binding]; other site 745776004437 catalytic triad [active] 745776004438 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 745776004439 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 745776004440 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 745776004441 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 745776004442 Family description; Region: UvrD_C_2; pfam13538 745776004443 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 745776004444 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 745776004445 catalytic residues [active] 745776004446 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 745776004447 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 745776004448 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 745776004449 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 745776004450 active site 745776004451 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 745776004452 DNA polymerase III, delta subunit; Region: holA; TIGR01128 745776004453 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 745776004454 Catalytic domain of Protein Kinases; Region: PKc; cd00180 745776004455 active site 745776004456 ATP binding site [chemical binding]; other site 745776004457 substrate binding site [chemical binding]; other site 745776004458 activation loop (A-loop); other site 745776004459 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 745776004460 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 745776004461 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 745776004462 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 745776004463 protein binding site [polypeptide binding]; other site 745776004464 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 745776004465 Active site serine [active] 745776004466 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 745776004467 Clp amino terminal domain; Region: Clp_N; pfam02861 745776004468 Clp amino terminal domain; Region: Clp_N; pfam02861 745776004469 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745776004470 Walker A motif; other site 745776004471 ATP binding site [chemical binding]; other site 745776004472 Walker B motif; other site 745776004473 arginine finger; other site 745776004474 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745776004475 Walker A motif; other site 745776004476 ATP binding site [chemical binding]; other site 745776004477 Walker B motif; other site 745776004478 arginine finger; other site 745776004479 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 745776004480 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 745776004481 active site 745776004482 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 745776004483 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 745776004484 active site 745776004485 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 745776004486 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 745776004487 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 745776004488 Cytochrome P450; Region: p450; cl12078 745776004489 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 745776004490 Cytochrome P450; Region: p450; cl12078 745776004491 Transcriptional regulator [Transcription]; Region: LytR; COG1316 745776004492 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 745776004493 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 745776004494 NADP binding site [chemical binding]; other site 745776004495 dimer interface [polypeptide binding]; other site 745776004496 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 745776004497 active site 745776004498 catalytic residues [active] 745776004499 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; cl01017 745776004500 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 745776004501 GAF domain; Region: GAF; pfam01590 745776004502 Phytochrome region; Region: PHY; pfam00360 745776004503 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776004504 ATP binding site [chemical binding]; other site 745776004505 Mg2+ binding site [ion binding]; other site 745776004506 G-X-G motif; other site 745776004507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776004508 intermolecular recognition site; other site 745776004509 active site 745776004510 dimerization interface [polypeptide binding]; other site 745776004511 Methyltransferase domain; Region: Methyltransf_23; pfam13489 745776004512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745776004513 S-adenosylmethionine binding site [chemical binding]; other site 745776004514 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 745776004515 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 745776004516 NodB motif; other site 745776004517 putative active site [active] 745776004518 putative catalytic site [active] 745776004519 putative Zn binding site [ion binding]; other site 745776004520 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 745776004521 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 745776004522 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 745776004523 Predicted permeases [General function prediction only]; Region: COG0795 745776004524 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 745776004525 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 745776004526 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 745776004527 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 745776004528 FAD binding site [chemical binding]; other site 745776004529 homotetramer interface [polypeptide binding]; other site 745776004530 substrate binding pocket [chemical binding]; other site 745776004531 catalytic base [active] 745776004532 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 745776004533 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14334 745776004534 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 745776004535 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 745776004536 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776004537 Walker A/P-loop; other site 745776004538 ATP binding site [chemical binding]; other site 745776004539 Q-loop/lid; other site 745776004540 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 745776004541 ABC transporter signature motif; other site 745776004542 Walker B; other site 745776004543 D-loop; other site 745776004544 H-loop/switch region; other site 745776004545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 745776004546 Chromate transporter; Region: Chromate_transp; pfam02417 745776004547 Chromate transporter; Region: Chromate_transp; pfam02417 745776004548 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 745776004549 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 745776004550 active site 745776004551 catalytic tetrad [active] 745776004552 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 745776004553 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 745776004554 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 745776004555 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 745776004556 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 745776004557 putative active site [active] 745776004558 metal binding site [ion binding]; metal-binding site 745776004559 homodimer binding site [polypeptide binding]; other site 745776004560 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 745776004561 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 745776004562 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 745776004563 active site 745776004564 metal binding site [ion binding]; metal-binding site 745776004565 ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636 745776004566 4-alpha-glucanotransferase; Provisional; Region: PRK14508 745776004567 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 745776004568 transcription elongation factor GreA; Region: greA; TIGR01462 745776004569 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 745776004570 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 745776004571 Walker A motif; other site 745776004572 ATP binding site [chemical binding]; other site 745776004573 Walker B motif; other site 745776004574 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 745776004575 active site 745776004576 nucleotide binding site [chemical binding]; other site 745776004577 HIGH motif; other site 745776004578 KMSKS motif; other site 745776004579 Membrane protein of unknown function; Region: DUF360; cl00850 745776004580 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 745776004581 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 745776004582 putative substrate binding pocket [chemical binding]; other site 745776004583 dimer interface [polypeptide binding]; other site 745776004584 phosphate binding site [ion binding]; other site 745776004585 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 745776004586 shikimate kinase; Provisional; Region: PRK13947 745776004587 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 745776004588 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 745776004589 active site 745776004590 KMSKS motif; other site 745776004591 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 745776004592 tRNA binding surface [nucleotide binding]; other site 745776004593 anticodon binding site; other site 745776004594 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 745776004595 dimer interface [polypeptide binding]; other site 745776004596 putative tRNA-binding site [nucleotide binding]; other site 745776004597 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 745776004598 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 745776004599 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14603 745776004600 RuvA N terminal domain; Region: RuvA_N; pfam01330 745776004601 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 745776004602 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 745776004603 DinB family; Region: DinB; cl17821 745776004604 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 745776004605 FMN binding site [chemical binding]; other site 745776004606 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 745776004607 dimer interface [polypeptide binding]; other site 745776004608 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 745776004609 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 745776004610 TPP-binding site; other site 745776004611 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 745776004612 PYR/PP interface [polypeptide binding]; other site 745776004613 dimer interface [polypeptide binding]; other site 745776004614 TPP binding site [chemical binding]; other site 745776004615 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 745776004616 PspA/IM30 family; Region: PspA_IM30; pfam04012 745776004617 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 745776004618 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745776004619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 745776004620 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 745776004621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776004622 dimer interface [polypeptide binding]; other site 745776004623 conserved gate region; other site 745776004624 putative PBP binding loops; other site 745776004625 ABC-ATPase subunit interface; other site 745776004626 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 745776004627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776004628 dimer interface [polypeptide binding]; other site 745776004629 conserved gate region; other site 745776004630 putative PBP binding loops; other site 745776004631 ABC-ATPase subunit interface; other site 745776004632 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 745776004633 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 745776004634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745776004635 putative substrate translocation pore; other site 745776004636 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 745776004637 16S rRNA methyltransferase B; Provisional; Region: PRK14902 745776004638 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 745776004639 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745776004640 S-adenosylmethionine binding site [chemical binding]; other site 745776004641 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 745776004642 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 745776004643 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 745776004644 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 745776004645 putative active site [active] 745776004646 putative catalytic site [active] 745776004647 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 745776004648 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 745776004649 putative dimer interface [polypeptide binding]; other site 745776004650 putative anticodon binding site; other site 745776004651 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 745776004652 homodimer interface [polypeptide binding]; other site 745776004653 motif 1; other site 745776004654 motif 2; other site 745776004655 active site 745776004656 motif 3; other site 745776004657 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745776004658 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 745776004659 active site 745776004660 motif I; other site 745776004661 motif II; other site 745776004662 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745776004663 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 745776004664 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 745776004665 acyl-activating enzyme (AAE) consensus motif; other site 745776004666 putative AMP binding site [chemical binding]; other site 745776004667 putative active site [active] 745776004668 putative CoA binding site [chemical binding]; other site 745776004669 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 745776004670 Cation efflux family; Region: Cation_efflux; pfam01545 745776004671 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 745776004672 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 745776004673 Walker A/P-loop; other site 745776004674 ATP binding site [chemical binding]; other site 745776004675 Q-loop/lid; other site 745776004676 ABC transporter signature motif; other site 745776004677 Walker B; other site 745776004678 D-loop; other site 745776004679 H-loop/switch region; other site 745776004680 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 745776004681 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 745776004682 ligand binding site [chemical binding]; other site 745776004683 flexible hinge region; other site 745776004684 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 745776004685 non-specific DNA interactions [nucleotide binding]; other site 745776004686 DNA binding site [nucleotide binding] 745776004687 sequence specific DNA binding site [nucleotide binding]; other site 745776004688 putative cAMP binding site [chemical binding]; other site 745776004689 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 745776004690 lysine biosynthesis protein LysW; Region: lysW; TIGR01206 745776004691 Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144 745776004692 ATP-grasp domain; Region: ATP-grasp_4; cl17255 745776004693 Catalytic domain of Protein Kinases; Region: PKc; cd00180 745776004694 active site 745776004695 ATP binding site [chemical binding]; other site 745776004696 substrate binding site [chemical binding]; other site 745776004697 activation loop (A-loop); other site 745776004698 methionine sulfoxide reductase A; Provisional; Region: PRK14054 745776004699 hypothetical protein; Provisional; Region: PRK10621 745776004700 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 745776004701 prephenate dehydrogenase; Validated; Region: PRK06545 745776004702 prephenate dehydrogenase; Validated; Region: PRK08507 745776004703 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 745776004704 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 745776004705 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 745776004706 Walker A/P-loop; other site 745776004707 ATP binding site [chemical binding]; other site 745776004708 Q-loop/lid; other site 745776004709 ABC transporter signature motif; other site 745776004710 Walker B; other site 745776004711 D-loop; other site 745776004712 H-loop/switch region; other site 745776004713 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 745776004714 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 745776004715 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 745776004716 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 745776004717 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 745776004718 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 745776004719 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 745776004720 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 745776004721 CHASE3 domain; Region: CHASE3; pfam05227 745776004722 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 745776004723 dimerization interface [polypeptide binding]; other site 745776004724 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 745776004725 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745776004726 metal binding site [ion binding]; metal-binding site 745776004727 active site 745776004728 I-site; other site 745776004729 DivIVA protein; Region: DivIVA; pfam05103 745776004730 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 745776004731 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 745776004732 catalytic residue [active] 745776004733 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 745776004734 dimer interface [polypeptide binding]; other site 745776004735 substrate binding site [chemical binding]; other site 745776004736 catalytic triad [active] 745776004737 Phosphoglycerate kinase; Region: PGK; pfam00162 745776004738 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 745776004739 substrate binding site [chemical binding]; other site 745776004740 hinge regions; other site 745776004741 ADP binding site [chemical binding]; other site 745776004742 catalytic site [active] 745776004743 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 745776004744 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 745776004745 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 745776004746 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 745776004747 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 745776004748 active site 745776004749 HIGH motif; other site 745776004750 nucleotide binding site [chemical binding]; other site 745776004751 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 745776004752 active site 745776004753 KMSKS motif; other site 745776004754 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 745776004755 tRNA binding surface [nucleotide binding]; other site 745776004756 anticodon binding site; other site 745776004757 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 745776004758 active site 745776004759 intersubunit interactions; other site 745776004760 catalytic residue [active] 745776004761 transcription termination factor Rho; Provisional; Region: rho; PRK09376 745776004762 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 745776004763 RNA binding site [nucleotide binding]; other site 745776004764 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 745776004765 multimer interface [polypeptide binding]; other site 745776004766 Walker A motif; other site 745776004767 ATP binding site [chemical binding]; other site 745776004768 Walker B motif; other site 745776004769 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776004770 Response regulator receiver domain; Region: Response_reg; pfam00072 745776004771 active site 745776004772 phosphorylation site [posttranslational modification] 745776004773 intermolecular recognition site; other site 745776004774 dimerization interface [polypeptide binding]; other site 745776004775 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 745776004776 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 745776004777 active site 745776004778 multimer interface [polypeptide binding]; other site 745776004779 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 745776004780 predicted active site [active] 745776004781 catalytic triad [active] 745776004782 YceI-like domain; Region: YceI; pfam04264 745776004783 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 745776004784 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 745776004785 aspartate kinase; Provisional; Region: PRK06291 745776004786 AAK_AK-LysC-like: Amino Acid Kinase Superfamily (AAK), AK-LysC-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive AK isoenzyme found in higher plants. The lysine-sensitive AK isoenzyme is a monofunctional...; Region: AAK_AK-LysC-like; cd04244 745776004787 putative catalytic residues [active] 745776004788 putative nucleotide binding site [chemical binding]; other site 745776004789 aspartate binding site [chemical binding]; other site 745776004790 dimer interface [polypeptide binding]; other site 745776004791 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 745776004792 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 745776004793 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 745776004794 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 745776004795 active site 745776004796 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 745776004797 gating phenylalanine in ion channel; other site 745776004798 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745776004799 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745776004800 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 745776004801 dimerization interface [polypeptide binding]; other site 745776004802 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 745776004803 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 745776004804 GIY-YIG motif/motif A; other site 745776004805 active site 745776004806 catalytic site [active] 745776004807 putative DNA binding site [nucleotide binding]; other site 745776004808 metal binding site [ion binding]; metal-binding site 745776004809 UvrB/uvrC motif; Region: UVR; pfam02151 745776004810 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 745776004811 PGAP1-like protein; Region: PGAP1; pfam07819 745776004812 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 745776004813 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 745776004814 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 745776004815 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 745776004816 catalytic site [active] 745776004817 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 745776004818 homodimer interface [polypeptide binding]; other site 745776004819 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745776004820 catalytic residue [active] 745776004821 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 745776004822 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 745776004823 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 745776004824 putative active site [active] 745776004825 catalytic triad [active] 745776004826 putative dimer interface [polypeptide binding]; other site 745776004827 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 745776004828 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 745776004829 active site 745776004830 catalytic residues [active] 745776004831 DNA binding site [nucleotide binding] 745776004832 Int/Topo IB signature motif; other site 745776004833 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 745776004834 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 745776004835 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 745776004836 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 745776004837 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 745776004838 dimer interface [polypeptide binding]; other site 745776004839 motif 1; other site 745776004840 active site 745776004841 motif 2; other site 745776004842 motif 3; other site 745776004843 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 745776004844 anticodon binding site; other site 745776004845 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 745776004846 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 745776004847 dimer interface [polypeptide binding]; other site 745776004848 anticodon binding site; other site 745776004849 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 745776004850 homodimer interface [polypeptide binding]; other site 745776004851 motif 1; other site 745776004852 active site 745776004853 motif 2; other site 745776004854 GAD domain; Region: GAD; pfam02938 745776004855 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 745776004856 active site 745776004857 motif 3; other site 745776004858 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 745776004859 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745776004860 motif II; other site 745776004861 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 745776004862 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 745776004863 active site 745776004864 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 745776004865 NlpC/P60 family; Region: NLPC_P60; cl17555 745776004866 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 745776004867 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 745776004868 active site 745776004869 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 745776004870 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 745776004871 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 745776004872 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 745776004873 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 745776004874 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 745776004875 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 745776004876 CoA binding domain; Region: CoA_binding; pfam02629 745776004877 CoA-ligase; Region: Ligase_CoA; pfam00549 745776004878 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 745776004879 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 745776004880 CoA-ligase; Region: Ligase_CoA; pfam00549 745776004881 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 745776004882 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 745776004883 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 745776004884 active site 745776004885 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 745776004886 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 745776004887 oligoendopeptidase F; Region: pepF; TIGR00181 745776004888 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 745776004889 active site 745776004890 Zn binding site [ion binding]; other site 745776004891 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 745776004892 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 745776004893 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 745776004894 Late embryogenesis abundant protein; Region: LEA_2; cl12118 745776004895 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745776004896 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 745776004897 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 745776004898 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 745776004899 intersubunit interface [polypeptide binding]; other site 745776004900 Amidase; Region: Amidase; cl11426 745776004901 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 745776004902 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776004903 Walker A/P-loop; other site 745776004904 ATP binding site [chemical binding]; other site 745776004905 Q-loop/lid; other site 745776004906 ABC transporter signature motif; other site 745776004907 Walker B; other site 745776004908 D-loop; other site 745776004909 H-loop/switch region; other site 745776004910 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 745776004911 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 745776004912 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 745776004913 Methyltransferase domain; Region: Methyltransf_23; pfam13489 745776004914 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745776004915 Coenzyme A binding pocket [chemical binding]; other site 745776004916 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 745776004917 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 745776004918 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 745776004919 active site 745776004920 FMN binding site [chemical binding]; other site 745776004921 substrate binding site [chemical binding]; other site 745776004922 homotetramer interface [polypeptide binding]; other site 745776004923 catalytic residue [active] 745776004924 LrgB-like family; Region: LrgB; cl00596 745776004925 LrgA family; Region: LrgA; cl00608 745776004926 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 745776004927 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 745776004928 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 745776004929 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 745776004930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745776004931 homodimer interface [polypeptide binding]; other site 745776004932 catalytic residue [active] 745776004933 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 745776004934 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 745776004935 Predicted transcriptional regulators [Transcription]; Region: COG1695 745776004936 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 745776004937 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 745776004938 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 745776004939 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 745776004940 dimer interface [polypeptide binding]; other site 745776004941 motif 1; other site 745776004942 active site 745776004943 motif 2; other site 745776004944 motif 3; other site 745776004945 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 745776004946 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 745776004947 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 745776004948 putative active site [active] 745776004949 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864 745776004950 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 745776004951 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 745776004952 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745776004953 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 745776004954 Walker A motif; other site 745776004955 ATP binding site [chemical binding]; other site 745776004956 Walker B motif; other site 745776004957 arginine finger; other site 745776004958 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 745776004959 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 745776004960 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331 745776004961 active site 745776004962 catalytic site [active] 745776004963 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 745776004964 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 745776004965 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 745776004966 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 745776004967 catalytic residue [active] 745776004968 PrcB C-terminal; Region: PrcB_C; pfam14343 745776004969 CcmB protein; Region: CcmB; cl17444 745776004970 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776004971 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 745776004972 Walker A/P-loop; other site 745776004973 ATP binding site [chemical binding]; other site 745776004974 Q-loop/lid; other site 745776004975 ABC transporter signature motif; other site 745776004976 Walker B; other site 745776004977 D-loop; other site 745776004978 H-loop/switch region; other site 745776004979 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 745776004980 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 745776004981 EDD domain protein, DegV family; Region: DegV; TIGR00762 745776004982 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 745776004983 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 745776004984 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 745776004985 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 745776004986 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 745776004987 NAD binding site [chemical binding]; other site 745776004988 ligand binding site [chemical binding]; other site 745776004989 catalytic site [active] 745776004990 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 745776004991 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 745776004992 Coenzyme A binding pocket [chemical binding]; other site 745776004993 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 745776004994 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 745776004995 active site 745776004996 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 745776004997 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 745776004998 anticodon binding site; other site 745776004999 Dimer interface [polypeptide binding]; other site 745776005000 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 745776005001 motif 1; other site 745776005002 dimer interface [polypeptide binding]; other site 745776005003 active site 745776005004 motif 2; other site 745776005005 motif 3; other site 745776005006 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745776005007 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 745776005008 metal binding site [ion binding]; metal-binding site 745776005009 active site 745776005010 I-site; other site 745776005011 Tetratricopeptide repeat; Region: TPR_12; pfam13424 745776005012 Tetratricopeptide repeat; Region: TPR_12; pfam13424 745776005013 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 745776005014 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745776005015 metal binding site [ion binding]; metal-binding site 745776005016 active site 745776005017 I-site; other site 745776005018 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 745776005019 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 745776005020 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 745776005021 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 745776005022 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 745776005023 active site 745776005024 substrate-binding site [chemical binding]; other site 745776005025 metal-binding site [ion binding] 745776005026 ATP binding site [chemical binding]; other site 745776005027 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 745776005028 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 745776005029 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 745776005030 putative RNA binding site [nucleotide binding]; other site 745776005031 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745776005032 S-adenosylmethionine binding site [chemical binding]; other site 745776005033 Protein of unknown function (DUF3208); Region: DUF3208; pfam11482 745776005034 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 745776005035 TPR motif; other site 745776005036 binding surface 745776005037 putative lipid kinase; Reviewed; Region: PRK13057 745776005038 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 745776005039 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 745776005040 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 745776005041 homodimer interface [polypeptide binding]; other site 745776005042 active site 745776005043 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 745776005044 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 745776005045 Mg++ binding site [ion binding]; other site 745776005046 putative catalytic motif [active] 745776005047 substrate binding site [chemical binding]; other site 745776005048 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 745776005049 active site 745776005050 Phosphotransferase enzyme family; Region: APH; pfam01636 745776005051 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 745776005052 active site 745776005053 substrate binding site [chemical binding]; other site 745776005054 ATP binding site [chemical binding]; other site 745776005055 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 745776005056 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 745776005057 Zn2+ binding site [ion binding]; other site 745776005058 Mg2+ binding site [ion binding]; other site 745776005059 Flagellin N-methylase; Region: FliB; cl00497 745776005060 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 745776005061 AAA domain; Region: AAA_33; pfam13671 745776005062 ATP-binding site [chemical binding]; other site 745776005063 Gluconate-6-phosphate binding site [chemical binding]; other site 745776005064 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 745776005065 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 745776005066 active site 745776005067 substrate binding site [chemical binding]; other site 745776005068 coenzyme B12 binding site [chemical binding]; other site 745776005069 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 745776005070 B12 binding site [chemical binding]; other site 745776005071 cobalt ligand [ion binding]; other site 745776005072 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 745776005073 trimer interface [polypeptide binding]; other site 745776005074 putative Zn binding site [ion binding]; other site 745776005075 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 745776005076 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 745776005077 substrate binding site [chemical binding]; other site 745776005078 hexamer interface [polypeptide binding]; other site 745776005079 metal binding site [ion binding]; metal-binding site 745776005080 2-phosphosulfolactate phosphatase; Provisional; Region: PRK14100 745776005081 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 745776005082 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 745776005083 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 745776005084 dimer interface [polypeptide binding]; other site 745776005085 active site 745776005086 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 745776005087 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 745776005088 active site 745776005089 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 745776005090 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 745776005091 active site 745776005092 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 745776005093 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 745776005094 NodB motif; other site 745776005095 putative active site [active] 745776005096 putative catalytic site [active] 745776005097 putative Zn binding site [ion binding]; other site 745776005098 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 745776005099 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 745776005100 DXD motif; other site 745776005101 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 745776005102 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745776005103 dimer interface [polypeptide binding]; other site 745776005104 phosphorylation site [posttranslational modification] 745776005105 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776005106 ATP binding site [chemical binding]; other site 745776005107 Mg2+ binding site [ion binding]; other site 745776005108 G-X-G motif; other site 745776005109 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 745776005110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776005111 active site 745776005112 phosphorylation site [posttranslational modification] 745776005113 intermolecular recognition site; other site 745776005114 dimerization interface [polypeptide binding]; other site 745776005115 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 745776005116 DNA binding site [nucleotide binding] 745776005117 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 745776005118 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 745776005119 substrate binding site [chemical binding]; other site 745776005120 oxyanion hole (OAH) forming residues; other site 745776005121 trimer interface [polypeptide binding]; other site 745776005122 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 745776005123 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 745776005124 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 745776005125 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 745776005126 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 745776005127 NAD(P) binding site [chemical binding]; other site 745776005128 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 745776005129 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 745776005130 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 745776005131 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 745776005132 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 745776005133 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 745776005134 active site 745776005135 catalytic site [active] 745776005136 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 745776005137 Walker A/P-loop; other site 745776005138 ATP binding site [chemical binding]; other site 745776005139 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 745776005140 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 745776005141 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 745776005142 ABC transporter signature motif; other site 745776005143 Walker B; other site 745776005144 D-loop; other site 745776005145 H-loop/switch region; other site 745776005146 Sporulation and spore germination; Region: Germane; cl11253 745776005147 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 745776005148 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713 745776005149 active site 745776005150 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 745776005151 SmpB-tmRNA interface; other site 745776005152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745776005153 short chain dehydrogenase; Provisional; Region: PRK07326 745776005154 NAD(P) binding site [chemical binding]; other site 745776005155 active site 745776005156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745776005157 S-adenosylmethionine binding site [chemical binding]; other site 745776005158 isocitrate dehydrogenase; Validated; Region: PRK07362 745776005159 isocitrate dehydrogenase; Reviewed; Region: PRK07006 745776005160 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 745776005161 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745776005162 Walker A/P-loop; other site 745776005163 ATP binding site [chemical binding]; other site 745776005164 Q-loop/lid; other site 745776005165 ABC transporter signature motif; other site 745776005166 Walker B; other site 745776005167 D-loop; other site 745776005168 H-loop/switch region; other site 745776005169 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 745776005170 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 745776005171 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745776005172 Walker A/P-loop; other site 745776005173 ATP binding site [chemical binding]; other site 745776005174 Q-loop/lid; other site 745776005175 ABC transporter signature motif; other site 745776005176 Walker B; other site 745776005177 D-loop; other site 745776005178 H-loop/switch region; other site 745776005179 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745776005180 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 745776005181 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 745776005182 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776005183 dimer interface [polypeptide binding]; other site 745776005184 conserved gate region; other site 745776005185 putative PBP binding loops; other site 745776005186 ABC-ATPase subunit interface; other site 745776005187 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 745776005188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776005189 dimer interface [polypeptide binding]; other site 745776005190 conserved gate region; other site 745776005191 putative PBP binding loops; other site 745776005192 ABC-ATPase subunit interface; other site 745776005193 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 745776005194 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 745776005195 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 745776005196 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 745776005197 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13829 745776005198 RimM N-terminal domain; Region: RimM; pfam01782 745776005199 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 745776005200 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 745776005201 G-X-X-G motif; other site 745776005202 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 745776005203 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 745776005204 Permutation of conserved domain; other site 745776005205 active site 745776005206 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 745776005207 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 745776005208 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 745776005209 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 745776005210 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 745776005211 active site 745776005212 dimer interface [polypeptide binding]; other site 745776005213 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 745776005214 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 745776005215 Putative peptidoglycan binding domain; Region: PG_binding_2; pfam08823 745776005216 Rrf2 family protein; Region: rrf2_super; TIGR00738 745776005217 Transcriptional regulator; Region: Rrf2; pfam02082 745776005218 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 745776005219 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 745776005220 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 745776005221 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 745776005222 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 745776005223 ligand-binding site [chemical binding]; other site 745776005224 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 745776005225 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 745776005226 Active Sites [active] 745776005227 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 745776005228 ATP-sulfurylase; Region: ATPS; cd00517 745776005229 active site 745776005230 HXXH motif; other site 745776005231 flexible loop; other site 745776005232 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 745776005233 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745776005234 substrate binding pocket [chemical binding]; other site 745776005235 membrane-bound complex binding site; other site 745776005236 hinge residues; other site 745776005237 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 745776005238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776005239 dimer interface [polypeptide binding]; other site 745776005240 conserved gate region; other site 745776005241 putative PBP binding loops; other site 745776005242 ABC-ATPase subunit interface; other site 745776005243 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 745776005244 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 745776005245 Walker A/P-loop; other site 745776005246 ATP binding site [chemical binding]; other site 745776005247 Q-loop/lid; other site 745776005248 ABC transporter signature motif; other site 745776005249 Walker B; other site 745776005250 D-loop; other site 745776005251 H-loop/switch region; other site 745776005252 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 745776005253 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 745776005254 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 745776005255 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 745776005256 acetylornithine aminotransferase; Provisional; Region: PRK02627 745776005257 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 745776005258 inhibitor-cofactor binding pocket; inhibition site 745776005259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745776005260 catalytic residue [active] 745776005261 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 745776005262 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 745776005263 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 745776005264 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 745776005265 ligand binding site; other site 745776005266 oligomer interface; other site 745776005267 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 745776005268 dimer interface [polypeptide binding]; other site 745776005269 N-terminal domain interface [polypeptide binding]; other site 745776005270 sulfate 1 binding site; other site 745776005271 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; cl17639 745776005272 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 745776005273 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 745776005274 putative dimer interface [polypeptide binding]; other site 745776005275 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 745776005276 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 745776005277 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 745776005278 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 745776005279 hinge; other site 745776005280 active site 745776005281 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 745776005282 DinB superfamily; Region: DinB_2; pfam12867 745776005283 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 745776005284 putative active site [active] 745776005285 putative metal binding site [ion binding]; other site 745776005286 catalytic site [active] 745776005287 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 745776005288 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 745776005289 NAD(P) binding pocket [chemical binding]; other site 745776005290 Transcriptional regulator; Region: Rrf2; pfam02082 745776005291 Predicted transcriptional regulator [Transcription]; Region: COG1959 745776005292 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 745776005293 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 745776005294 NADP binding site [chemical binding]; other site 745776005295 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 745776005296 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 745776005297 tetramer interface [polypeptide binding]; other site 745776005298 heme binding pocket [chemical binding]; other site 745776005299 NADPH binding site [chemical binding]; other site 745776005300 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 745776005301 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 745776005302 dimer interface [polypeptide binding]; other site 745776005303 active site 745776005304 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 745776005305 catalytic residues [active] 745776005306 substrate binding site [chemical binding]; other site 745776005307 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 745776005308 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 745776005309 Protein of unknown function (DUF554); Region: DUF554; cl00784 745776005310 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 745776005311 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 745776005312 homodimer interface [polypeptide binding]; other site 745776005313 NAD binding pocket [chemical binding]; other site 745776005314 ATP binding pocket [chemical binding]; other site 745776005315 Mg binding site [ion binding]; other site 745776005316 active-site loop [active] 745776005317 Ferritin-like domain; Region: Ferritin_2; pfam13668 745776005318 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745776005319 NAD(P) binding site [chemical binding]; other site 745776005320 active site 745776005321 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 745776005322 nucleotide binding site/active site [active] 745776005323 HIT family signature motif; other site 745776005324 catalytic residue [active] 745776005325 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 745776005326 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745776005327 motif II; other site 745776005328 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 745776005329 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 745776005330 dimerization interface [polypeptide binding]; other site 745776005331 ligand binding site [chemical binding]; other site 745776005332 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 745776005333 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 745776005334 TM-ABC transporter signature motif; other site 745776005335 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 745776005336 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 745776005337 TM-ABC transporter signature motif; other site 745776005338 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 745776005339 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 745776005340 Walker A/P-loop; other site 745776005341 ATP binding site [chemical binding]; other site 745776005342 Q-loop/lid; other site 745776005343 ABC transporter signature motif; other site 745776005344 Walker B; other site 745776005345 D-loop; other site 745776005346 H-loop/switch region; other site 745776005347 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 745776005348 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 745776005349 Walker A/P-loop; other site 745776005350 ATP binding site [chemical binding]; other site 745776005351 Q-loop/lid; other site 745776005352 ABC transporter signature motif; other site 745776005353 Walker B; other site 745776005354 D-loop; other site 745776005355 H-loop/switch region; other site 745776005356 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 745776005357 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745776005358 Walker A motif; other site 745776005359 ATP binding site [chemical binding]; other site 745776005360 Walker B motif; other site 745776005361 arginine finger; other site 745776005362 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745776005363 Walker A motif; other site 745776005364 ATP binding site [chemical binding]; other site 745776005365 Walker B motif; other site 745776005366 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 745776005367 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 745776005368 TrkA-C domain; Region: TrkA_C; pfam02080 745776005369 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 745776005370 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 745776005371 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 745776005372 oligomer interface [polypeptide binding]; other site 745776005373 active site 745776005374 metal binding site [ion binding]; metal-binding site 745776005375 Major Facilitator Superfamily; Region: MFS_1; pfam07690 745776005376 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 745776005377 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 745776005378 Walker A/P-loop; other site 745776005379 ATP binding site [chemical binding]; other site 745776005380 Q-loop/lid; other site 745776005381 ABC transporter signature motif; other site 745776005382 Walker B; other site 745776005383 D-loop; other site 745776005384 H-loop/switch region; other site 745776005385 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 745776005386 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 745776005387 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 745776005388 DctM-like transporters; Region: DctM; pfam06808 745776005389 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 745776005390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776005391 active site 745776005392 phosphorylation site [posttranslational modification] 745776005393 intermolecular recognition site; other site 745776005394 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 745776005395 dimerization interface [polypeptide binding]; other site 745776005396 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745776005397 dimer interface [polypeptide binding]; other site 745776005398 phosphorylation site [posttranslational modification] 745776005399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776005400 ATP binding site [chemical binding]; other site 745776005401 Mg2+ binding site [ion binding]; other site 745776005402 G-X-G motif; other site 745776005403 CHASE domain; Region: CHASE; cl01369 745776005404 PAS domain S-box; Region: sensory_box; TIGR00229 745776005405 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 745776005406 putative active site [active] 745776005407 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 745776005408 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 745776005409 heme pocket [chemical binding]; other site 745776005410 putative active site [active] 745776005411 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 745776005412 putative active site [active] 745776005413 heme pocket [chemical binding]; other site 745776005414 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745776005415 dimer interface [polypeptide binding]; other site 745776005416 phosphorylation site [posttranslational modification] 745776005417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776005418 ATP binding site [chemical binding]; other site 745776005419 Mg2+ binding site [ion binding]; other site 745776005420 G-X-G motif; other site 745776005421 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 745776005422 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 745776005423 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 745776005424 NAD(P) binding site [chemical binding]; other site 745776005425 shikimate binding site; other site 745776005426 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 745776005427 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 745776005428 putative active site [active] 745776005429 catalytic site [active] 745776005430 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 745776005431 putative active site [active] 745776005432 catalytic site [active] 745776005433 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 745776005434 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 745776005435 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 745776005436 putative catalytic cysteine [active] 745776005437 gamma-glutamyl kinase; Provisional; Region: PRK05429 745776005438 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 745776005439 nucleotide binding site [chemical binding]; other site 745776005440 homotetrameric interface [polypeptide binding]; other site 745776005441 putative phosphate binding site [ion binding]; other site 745776005442 putative allosteric binding site; other site 745776005443 PUA domain; Region: PUA; pfam01472 745776005444 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 745776005445 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 745776005446 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 745776005447 putative homodimer interface [polypeptide binding]; other site 745776005448 putative active site pocket [active] 745776005449 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 745776005450 MG2 domain; Region: A2M_N; pfam01835 745776005451 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 745776005452 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 745776005453 putative active site [active] 745776005454 putative metal binding site [ion binding]; other site 745776005455 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 745776005456 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 745776005457 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 745776005458 DHHA1 domain; Region: DHHA1; pfam02272 745776005459 Cupin domain; Region: Cupin_2; cl17218 745776005460 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 745776005461 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 745776005462 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 745776005463 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 745776005464 MarR family; Region: MarR_2; pfam12802 745776005465 LGFP repeat; Region: LGFP; pfam08310 745776005466 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 745776005467 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 745776005468 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 745776005469 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745776005470 active site 745776005471 motif I; other site 745776005472 motif II; other site 745776005473 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 745776005474 Protein of unknown function (DUF1622); Region: DUF1622; cl01991 745776005475 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 745776005476 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 745776005477 ATP binding site [chemical binding]; other site 745776005478 putative Mg++ binding site [ion binding]; other site 745776005479 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 745776005480 nucleotide binding region [chemical binding]; other site 745776005481 ATP-binding site [chemical binding]; other site 745776005482 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 745776005483 HRDC domain; Region: HRDC; pfam00570 745776005484 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 745776005485 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 745776005486 peptide binding site [polypeptide binding]; other site 745776005487 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 745776005488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776005489 dimer interface [polypeptide binding]; other site 745776005490 conserved gate region; other site 745776005491 putative PBP binding loops; other site 745776005492 ABC-ATPase subunit interface; other site 745776005493 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 745776005494 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 745776005495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776005496 dimer interface [polypeptide binding]; other site 745776005497 conserved gate region; other site 745776005498 putative PBP binding loops; other site 745776005499 ABC-ATPase subunit interface; other site 745776005500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776005501 dimer interface [polypeptide binding]; other site 745776005502 conserved gate region; other site 745776005503 putative PBP binding loops; other site 745776005504 ABC-ATPase subunit interface; other site 745776005505 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 745776005506 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745776005507 substrate binding pocket [chemical binding]; other site 745776005508 membrane-bound complex binding site; other site 745776005509 hinge residues; other site 745776005510 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 745776005511 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 745776005512 Walker A/P-loop; other site 745776005513 ATP binding site [chemical binding]; other site 745776005514 Q-loop/lid; other site 745776005515 ABC transporter signature motif; other site 745776005516 Walker B; other site 745776005517 D-loop; other site 745776005518 H-loop/switch region; other site 745776005519 TOBE domain; Region: TOBE; pfam03459 745776005520 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 745776005521 nucleophilic elbow; other site 745776005522 catalytic triad; other site 745776005523 Transglycosylase; Region: Transgly; pfam00912 745776005524 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 745776005525 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 745776005526 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 745776005527 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 745776005528 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 745776005529 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776005530 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 745776005531 Walker A/P-loop; other site 745776005532 ATP binding site [chemical binding]; other site 745776005533 ABC transporter signature motif; other site 745776005534 Walker B; other site 745776005535 D-loop; other site 745776005536 H-loop/switch region; other site 745776005537 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776005538 Walker A/P-loop; other site 745776005539 ATP binding site [chemical binding]; other site 745776005540 Q-loop/lid; other site 745776005541 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 745776005542 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 745776005543 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 745776005544 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745776005545 Annotation is too short ref|YP_006261190| 745776005546 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 745776005547 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 745776005548 endonuclease III; Region: ENDO3c; smart00478 745776005549 minor groove reading motif; other site 745776005550 helix-hairpin-helix signature motif; other site 745776005551 substrate binding pocket [chemical binding]; other site 745776005552 active site 745776005553 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 745776005554 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 745776005555 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776005556 Walker A/P-loop; other site 745776005557 ATP binding site [chemical binding]; other site 745776005558 Q-loop/lid; other site 745776005559 ABC transporter signature motif; other site 745776005560 Walker B; other site 745776005561 D-loop; other site 745776005562 H-loop/switch region; other site 745776005563 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 745776005564 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 745776005565 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 745776005566 PRC-barrel domain; Region: PRC; pfam05239 745776005567 PRC-barrel domain; Region: PRC; pfam05239 745776005568 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 745776005569 Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and residues that can...; Region: MLE_like; cd03315 745776005570 active site 745776005571 aconitate hydratase; Validated; Region: PRK09277 745776005572 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 745776005573 substrate binding site [chemical binding]; other site 745776005574 ligand binding site [chemical binding]; other site 745776005575 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 745776005576 substrate binding site [chemical binding]; other site 745776005577 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 745776005578 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 745776005579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776005580 dimer interface [polypeptide binding]; other site 745776005581 conserved gate region; other site 745776005582 putative PBP binding loops; other site 745776005583 ABC-ATPase subunit interface; other site 745776005584 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 745776005585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776005586 dimer interface [polypeptide binding]; other site 745776005587 conserved gate region; other site 745776005588 putative PBP binding loops; other site 745776005589 ABC-ATPase subunit interface; other site 745776005590 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 745776005591 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 745776005592 active site 745776005593 ribulose/triose binding site [chemical binding]; other site 745776005594 phosphate binding site [ion binding]; other site 745776005595 substrate (anthranilate) binding pocket [chemical binding]; other site 745776005596 product (indole) binding pocket [chemical binding]; other site 745776005597 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 745776005598 active site 745776005599 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 745776005600 transmembrane helices; other site 745776005601 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 745776005602 AAA domain; Region: AAA_30; pfam13604 745776005603 Family description; Region: UvrD_C_2; pfam13538 745776005604 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 745776005605 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 745776005606 active site 745776005607 metal binding site [ion binding]; metal-binding site 745776005608 DNA binding site [nucleotide binding] 745776005609 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 745776005610 AAA domain; Region: AAA_23; pfam13476 745776005611 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776005612 Walker A/P-loop; other site 745776005613 ATP binding site [chemical binding]; other site 745776005614 Q-loop/lid; other site 745776005615 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 745776005616 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776005617 ABC transporter signature motif; other site 745776005618 Walker B; other site 745776005619 D-loop; other site 745776005620 H-loop/switch region; other site 745776005621 OsmC-like protein; Region: OsmC; cl00767 745776005622 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 745776005623 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 745776005624 putative active site [active] 745776005625 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 745776005626 Cytochrome P450; Region: p450; cl12078 745776005627 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 745776005628 active site 745776005629 ATP binding site [chemical binding]; other site 745776005630 benzoate transport; Region: 2A0115; TIGR00895 745776005631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745776005632 putative substrate translocation pore; other site 745776005633 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 745776005634 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 745776005635 active site 745776005636 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 745776005637 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 745776005638 active site 745776005639 KMSKS motif; other site 745776005640 ArgK protein; Region: ArgK; pfam03308 745776005641 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 745776005642 Walker A; other site 745776005643 DNA repair protein RadA; Provisional; Region: PRK11823 745776005644 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 745776005645 Walker A motif; other site 745776005646 ATP binding site [chemical binding]; other site 745776005647 Walker B motif; other site 745776005648 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 745776005649 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 745776005650 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 745776005651 ATP binding site [chemical binding]; other site 745776005652 Mg++ binding site [ion binding]; other site 745776005653 motif III; other site 745776005654 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 745776005655 nucleotide binding region [chemical binding]; other site 745776005656 ATP-binding site [chemical binding]; other site 745776005657 RNA-binding GUCT-like domain found in Thermus thermophilus heat resistant RNA-dependent ATPase (Hera) and similar proteins; Region: GUCT_Hera; cd12938 745776005658 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 745776005659 rRNA interaction site [nucleotide binding]; other site 745776005660 S8 interaction site; other site 745776005661 putative laminin-1 binding site; other site 745776005662 elongation factor Ts; Provisional; Region: tsf; PRK09377 745776005663 UBA/TS-N domain; Region: UBA; pfam00627 745776005664 Elongation factor TS; Region: EF_TS; pfam00889 745776005665 Elongation factor TS; Region: EF_TS; pfam00889 745776005666 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 745776005667 putative nucleotide binding site [chemical binding]; other site 745776005668 uridine monophosphate binding site [chemical binding]; other site 745776005669 homohexameric interface [polypeptide binding]; other site 745776005670 ribosome recycling factor; Reviewed; Region: frr; PRK00083 745776005671 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 745776005672 hinge region; other site 745776005673 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 745776005674 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 745776005675 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 745776005676 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 745776005677 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 745776005678 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 745776005679 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 745776005680 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 745776005681 active site 745776005682 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 745776005683 protein binding site [polypeptide binding]; other site 745776005684 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 745776005685 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 745776005686 metal binding sites [ion binding]; metal-binding site 745776005687 dimer interface [polypeptide binding]; other site 745776005688 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 745776005689 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 745776005690 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 745776005691 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 745776005692 active site 745776005693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745776005694 MFS/sugar transport protein; Region: MFS_2; pfam13347 745776005695 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 745776005696 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 745776005697 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 745776005698 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 745776005699 hinge; other site 745776005700 active site 745776005701 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 745776005702 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 745776005703 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 745776005704 NlpC/P60 family; Region: NLPC_P60; pfam00877 745776005705 H+ Antiporter protein; Region: 2A0121; TIGR00900 745776005706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745776005707 putative substrate translocation pore; other site 745776005708 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 745776005709 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 745776005710 TPR motif; other site 745776005711 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 745776005712 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 745776005713 NodB motif; other site 745776005714 putative active site [active] 745776005715 putative catalytic site [active] 745776005716 putative Zn binding site [ion binding]; other site 745776005717 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 745776005718 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 745776005719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745776005720 S-adenosylmethionine binding site [chemical binding]; other site 745776005721 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 745776005722 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 745776005723 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 745776005724 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 745776005725 active site 745776005726 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 745776005727 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745776005728 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 745776005729 30S subunit binding site; other site 745776005730 butyrate kinase; Provisional; Region: PRK03011 745776005731 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 745776005732 active site 745776005733 catalytic residues [active] 745776005734 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 745776005735 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 745776005736 NMT1-like family; Region: NMT1_2; pfam13379 745776005737 membrane-bound complex binding site; other site 745776005738 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 745776005739 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 745776005740 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 745776005741 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 745776005742 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 745776005743 catalytic residues [active] 745776005744 catalytic nucleophile [active] 745776005745 Recombinase; Region: Recombinase; pfam07508 745776005746 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 745776005747 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 745776005748 Domain of unknown function (DUF955); Region: DUF955; cl01076 745776005749 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745776005750 non-specific DNA binding site [nucleotide binding]; other site 745776005751 salt bridge; other site 745776005752 sequence-specific DNA binding site [nucleotide binding]; other site 745776005753 replicative DNA helicase; Region: DnaB; TIGR00665 745776005754 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 745776005755 Walker A motif; other site 745776005756 ATP binding site [chemical binding]; other site 745776005757 Walker B motif; other site 745776005758 VRR-NUC domain; Region: VRR_NUC; pfam08774 745776005759 Terminase small subunit; Region: Terminase_2; cl01513 745776005760 Phage terminase large subunit; Region: Terminase_3; cl12054 745776005761 Phage portal protein; Region: Phage_portal; pfam04860 745776005762 Phage-related protein [Function unknown]; Region: COG4695; cl01923 745776005763 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 745776005764 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 745776005765 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 745776005766 Phage capsid family; Region: Phage_capsid; pfam05065 745776005767 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 745776005768 Phage-related minor tail protein [Function unknown]; Region: COG5280 745776005769 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 745776005770 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 745776005771 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 745776005772 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 745776005773 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 745776005774 active site 745776005775 Zn binding site [ion binding]; other site 745776005776 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 745776005777 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 745776005778 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 745776005779 putative dimer interface [polypeptide binding]; other site 745776005780 N-terminal domain interface [polypeptide binding]; other site 745776005781 putative substrate binding pocket (H-site) [chemical binding]; other site 745776005782 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 745776005783 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745776005784 Coenzyme A binding pocket [chemical binding]; other site 745776005785 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 745776005786 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745776005787 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 745776005788 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745776005789 NAD(P) binding site [chemical binding]; other site 745776005790 active site 745776005791 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 745776005792 Uncharacterized conserved protein [Function unknown]; Region: COG1432 745776005793 LabA_like proteins; Region: LabA; cd10911 745776005794 putative metal binding site [ion binding]; other site 745776005795 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 745776005796 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 745776005797 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 745776005798 catalytic residue [active] 745776005799 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 745776005800 MarR family; Region: MarR; pfam01047 745776005801 MarR family; Region: MarR_2; cl17246 745776005802 Predicted secreted protein (DUF2259); Region: DUF2259; cl02309 745776005803 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 745776005804 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 745776005805 Catalytic site [active] 745776005806 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 745776005807 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 745776005808 PYR/PP interface [polypeptide binding]; other site 745776005809 dimer interface [polypeptide binding]; other site 745776005810 TPP binding site [chemical binding]; other site 745776005811 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 745776005812 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 745776005813 TPP-binding site [chemical binding]; other site 745776005814 dimer interface [polypeptide binding]; other site 745776005815 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 745776005816 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 745776005817 putative valine binding site [chemical binding]; other site 745776005818 dimer interface [polypeptide binding]; other site 745776005819 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 745776005820 ketol-acid reductoisomerase; Provisional; Region: PRK05479 745776005821 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 745776005822 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 745776005823 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 745776005824 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 745776005825 active site 745776005826 catalytic tetrad [active] 745776005827 2-isopropylmalate synthase; Validated; Region: PRK00915 745776005828 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 745776005829 active site 745776005830 metal binding site [ion binding]; metal-binding site 745776005831 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 745776005832 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 745776005833 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 745776005834 active site 745776005835 metal binding site [ion binding]; metal-binding site 745776005836 DinB superfamily; Region: DinB_2; pfam12867 745776005837 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 745776005838 Endonuclease I; Region: Endonuclease_1; cl01003 745776005839 GAF domain; Region: GAF; cl17456 745776005840 GAF domain; Region: GAF_3; pfam13492 745776005841 GAF domain; Region: GAF_2; pfam13185 745776005842 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745776005843 dimer interface [polypeptide binding]; other site 745776005844 phosphorylation site [posttranslational modification] 745776005845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776005846 ATP binding site [chemical binding]; other site 745776005847 Mg2+ binding site [ion binding]; other site 745776005848 G-X-G motif; other site 745776005849 PAS domain S-box; Region: sensory_box; TIGR00229 745776005850 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 745776005851 putative active site [active] 745776005852 heme pocket [chemical binding]; other site 745776005853 GAF domain; Region: GAF; pfam01590 745776005854 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 745776005855 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745776005856 dimer interface [polypeptide binding]; other site 745776005857 phosphorylation site [posttranslational modification] 745776005858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776005859 ATP binding site [chemical binding]; other site 745776005860 Mg2+ binding site [ion binding]; other site 745776005861 G-X-G motif; other site 745776005862 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 745776005863 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 745776005864 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 745776005865 Terminase small subunit; Region: Terminase_2; cl01513 745776005866 Phage terminase large subunit; Region: Terminase_3; cl12054 745776005867 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 745776005868 TIR domain; Region: TIR_2; pfam13676 745776005869 TIR domain; Region: TIR_2; pfam13676 745776005870 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 745776005871 salt bridge; other site 745776005872 non-specific DNA binding site [nucleotide binding]; other site 745776005873 sequence-specific DNA binding site [nucleotide binding]; other site 745776005874 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 745776005875 Predicted membrane protein [Function unknown]; Region: COG1470 745776005876 baseplate wedge subunit; Provisional; Region: 7; PHA02579 745776005877 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 745776005878 DNA methylase; Region: N6_N4_Mtase; pfam01555 745776005879 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 745776005880 Restriction endonuclease; Region: Mrr_cat; pfam04471 745776005881 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 745776005882 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 745776005883 HIGH motif; other site 745776005884 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 745776005885 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 745776005886 active site 745776005887 KMSKS motif; other site 745776005888 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 745776005889 tRNA binding surface [nucleotide binding]; other site 745776005890 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 745776005891 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 745776005892 malonyl-CoA binding site [chemical binding]; other site 745776005893 dimer interface [polypeptide binding]; other site 745776005894 active site 745776005895 product binding site; other site 745776005896 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 745776005897 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 745776005898 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 745776005899 trimer interface [polypeptide binding]; other site 745776005900 putative metal binding site [ion binding]; other site 745776005901 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 745776005902 Peptidase family M48; Region: Peptidase_M48; pfam01435 745776005903 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 745776005904 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 745776005905 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 745776005906 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 745776005907 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 745776005908 catalytic residues [active] 745776005909 Cytochrome C biogenesis protein; Region: CcmH; cl01179 745776005910 TPR repeat; Region: TPR_11; pfam13414 745776005911 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 745776005912 TPR motif; other site 745776005913 binding surface 745776005914 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 745776005915 active site 745776005916 substrate binding site [chemical binding]; other site 745776005917 ATP binding site [chemical binding]; other site 745776005918 4-aminobutyrate aminotransferase; Provisional; Region: PRK05769 745776005919 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 745776005920 inhibitor-cofactor binding pocket; inhibition site 745776005921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745776005922 catalytic residue [active] 745776005923 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 745776005924 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 745776005925 FeS/SAM binding site; other site 745776005926 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 745776005927 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 745776005928 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 745776005929 putative DNA binding site [nucleotide binding]; other site 745776005930 putative Zn2+ binding site [ion binding]; other site 745776005931 AsnC family; Region: AsnC_trans_reg; pfam01037 745776005932 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cl00653 745776005933 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 745776005934 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 745776005935 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 745776005936 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320 745776005937 putative tRNA-binding site [nucleotide binding]; other site 745776005938 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776005939 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 745776005940 Walker A/P-loop; other site 745776005941 ATP binding site [chemical binding]; other site 745776005942 Q-loop/lid; other site 745776005943 ABC transporter signature motif; other site 745776005944 Walker B; other site 745776005945 D-loop; other site 745776005946 H-loop/switch region; other site 745776005947 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 745776005948 active site 745776005949 DNA binding site [nucleotide binding] 745776005950 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 745776005951 active site 745776005952 DNA binding site [nucleotide binding] 745776005953 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 745776005954 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 745776005955 Phosphotransferase enzyme family; Region: APH; pfam01636 745776005956 Protein of unknown function (DUF1679); Region: DUF1679; pfam07914 745776005957 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 745776005958 metal binding site [ion binding]; metal-binding site 745776005959 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 745776005960 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 745776005961 NAD(P) binding site [chemical binding]; other site 745776005962 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 745776005963 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 745776005964 putative active site [active] 745776005965 oxyanion strand; other site 745776005966 catalytic triad [active] 745776005967 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 745776005968 putative active site pocket [active] 745776005969 4-fold oligomerization interface [polypeptide binding]; other site 745776005970 metal binding residues [ion binding]; metal-binding site 745776005971 3-fold/trimer interface [polypeptide binding]; other site 745776005972 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 745776005973 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 745776005974 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745776005975 S-adenosylmethionine binding site [chemical binding]; other site 745776005976 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 745776005977 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 745776005978 ATP binding site [chemical binding]; other site 745776005979 putative Mg++ binding site [ion binding]; other site 745776005980 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 745776005981 nucleotide binding region [chemical binding]; other site 745776005982 ATP-binding site [chemical binding]; other site 745776005983 Helicase associated domain (HA2); Region: HA2; cl04503 745776005984 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 745776005985 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 745776005986 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745776005987 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 745776005988 motif II; other site 745776005989 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 745776005990 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 745776005991 short chain dehydrogenase; Provisional; Region: PRK08219 745776005992 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745776005993 NAD(P) binding site [chemical binding]; other site 745776005994 active site 745776005995 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 745776005996 dimer interface [polypeptide binding]; other site 745776005997 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745776005998 Coenzyme A binding pocket [chemical binding]; other site 745776005999 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 745776006000 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 745776006001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 745776006002 short chain dehydrogenase; Provisional; Region: PRK06197 745776006003 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 745776006004 putative NAD(P) binding site [chemical binding]; other site 745776006005 active site 745776006006 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 745776006007 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 745776006008 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 745776006009 active site 745776006010 HIGH motif; other site 745776006011 KMSK motif region; other site 745776006012 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 745776006013 tRNA binding surface [nucleotide binding]; other site 745776006014 anticodon binding site; other site 745776006015 Cytochrome c553 [Energy production and conversion]; Region: COG2863 745776006016 Cytochrome c; Region: Cytochrom_C; pfam00034 745776006017 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 745776006018 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 745776006019 active site residue [active] 745776006020 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 745776006021 catalytic core [active] 745776006022 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 745776006023 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 745776006024 putative dimer interface [polypeptide binding]; other site 745776006025 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 745776006026 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 745776006027 active site 745776006028 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 745776006029 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 745776006030 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 745776006031 dihydroorotase; Validated; Region: pyrC; PRK09357 745776006032 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 745776006033 active site 745776006034 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 745776006035 catalytic residues [active] 745776006036 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 745776006037 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 745776006038 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 745776006039 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 745776006040 nudix motif; other site 745776006041 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 745776006042 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 745776006043 putative catalytic residues [active] 745776006044 hypothetical protein; Validated; Region: PRK00153 745776006045 recombination protein RecR; Reviewed; Region: recR; PRK00076 745776006046 RecR protein; Region: RecR; pfam02132 745776006047 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 745776006048 putative active site [active] 745776006049 putative metal-binding site [ion binding]; other site 745776006050 tetramer interface [polypeptide binding]; other site 745776006051 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 745776006052 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 745776006053 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 745776006054 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 745776006055 NAD(P) binding site [chemical binding]; other site 745776006056 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 745776006057 SxDxEG motif; other site 745776006058 active site 745776006059 metal binding site [ion binding]; metal-binding site 745776006060 homopentamer interface [polypeptide binding]; other site 745776006061 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 745776006062 RecX family; Region: RecX; cl00936 745776006063 Predicted phosphohydrolase [General function prediction only]; Region: COG1768 745776006064 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 745776006065 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 745776006066 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 745776006067 tetramer interface [polypeptide binding]; other site 745776006068 TPP-binding site [chemical binding]; other site 745776006069 heterodimer interface [polypeptide binding]; other site 745776006070 phosphorylation loop region [posttranslational modification] 745776006071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 745776006072 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 745776006073 alpha subunit interface [polypeptide binding]; other site 745776006074 TPP binding site [chemical binding]; other site 745776006075 heterodimer interface [polypeptide binding]; other site 745776006076 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 745776006077 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 745776006078 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 745776006079 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 745776006080 NAD(P) binding site [chemical binding]; other site 745776006081 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 745776006082 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 745776006083 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 745776006084 NAD(P) binding site [chemical binding]; other site 745776006085 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 745776006086 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 745776006087 active site 745776006088 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 745776006089 AsnC family; Region: AsnC_trans_reg; pfam01037 745776006090 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 745776006091 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 745776006092 hexamer interface [polypeptide binding]; other site 745776006093 ligand binding site [chemical binding]; other site 745776006094 putative active site [active] 745776006095 NAD(P) binding site [chemical binding]; other site 745776006096 recombination factor protein RarA; Reviewed; Region: PRK13342 745776006097 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745776006098 Walker A motif; other site 745776006099 ATP binding site [chemical binding]; other site 745776006100 Walker B motif; other site 745776006101 arginine finger; other site 745776006102 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 745776006103 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 745776006104 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 745776006105 oligomer interface [polypeptide binding]; other site 745776006106 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 745776006107 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 745776006108 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 745776006109 Cu(I) binding site [ion binding]; other site 745776006110 Protein of unknown function (DUF461); Region: DUF461; pfam04314 745776006111 Transcriptional regulators [Transcription]; Region: PurR; COG1609 745776006112 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745776006113 DNA binding site [nucleotide binding] 745776006114 domain linker motif; other site 745776006115 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 745776006116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 745776006117 MOSC domain; Region: MOSC; pfam03473 745776006118 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 745776006119 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 745776006120 putative active site [active] 745776006121 catalytic site [active] 745776006122 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 745776006123 putative active site [active] 745776006124 catalytic site [active] 745776006125 RNHCP domain; Region: RNHCP; pfam12647 745776006126 Family of unknown function (DUF490); Region: DUF490; pfam04357 745776006127 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 745776006128 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776006129 Walker A/P-loop; other site 745776006130 ATP binding site [chemical binding]; other site 745776006131 ABC transporter signature motif; other site 745776006132 Walker B; other site 745776006133 D-loop; other site 745776006134 H-loop/switch region; other site 745776006135 ABC transporter; Region: ABC_tran_2; pfam12848 745776006136 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 745776006137 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 745776006138 Amidase; Region: Amidase; cl11426 745776006139 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 745776006140 Prephenate dehydratase; Region: PDT; pfam00800 745776006141 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 745776006142 putative L-Phe binding site [chemical binding]; other site 745776006143 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 745776006144 YciI-like protein; Reviewed; Region: PRK12866 745776006145 NLI interacting factor-like phosphatase; Region: NIF; pfam03031 745776006146 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 745776006147 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 745776006148 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 745776006149 substrate binding pocket [chemical binding]; other site 745776006150 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 745776006151 B12 binding site [chemical binding]; other site 745776006152 cobalt ligand [ion binding]; other site 745776006153 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 745776006154 5,10-methylenetetrahydrofolate reductase [Amino acid transport and metabolism]; Region: MetF; COG0685 745776006155 FAD binding site [chemical binding]; other site 745776006156 Uncharacterized conserved protein [Function unknown]; Region: COG5316 745776006157 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 745776006158 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 745776006159 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 745776006160 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 745776006161 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 745776006162 Ligand binding site [chemical binding]; other site 745776006163 Electron transfer flavoprotein domain; Region: ETF; pfam01012 745776006164 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 745776006165 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 745776006166 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 745776006167 active site 745776006168 NAD binding site [chemical binding]; other site 745776006169 metal binding site [ion binding]; metal-binding site 745776006170 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 745776006171 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 745776006172 FOG: CBS domain [General function prediction only]; Region: COG0517 745776006173 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 745776006174 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 745776006175 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 745776006176 catalytic residue [active] 745776006177 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 745776006178 dimer interface [polypeptide binding]; other site 745776006179 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 745776006180 ligand binding site [chemical binding]; other site 745776006181 FOG: WD40 repeat [General function prediction only]; Region: COG2319 745776006182 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 745776006183 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 745776006184 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 745776006185 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 745776006186 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 745776006187 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 745776006188 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 745776006189 ligand binding site [chemical binding]; other site 745776006190 NAD binding site [chemical binding]; other site 745776006191 dimerization interface [polypeptide binding]; other site 745776006192 catalytic site [active] 745776006193 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 745776006194 putative L-serine binding site [chemical binding]; other site 745776006195 manganese transport protein MntH; Reviewed; Region: PRK00701 745776006196 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 745776006197 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 745776006198 Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl17317 745776006199 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 745776006200 putative active site [active] 745776006201 putative CoA binding site [chemical binding]; other site 745776006202 nudix motif; other site 745776006203 metal binding site [ion binding]; metal-binding site 745776006204 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 745776006205 PEGA domain; Region: PEGA; pfam08308 745776006206 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 745776006207 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 745776006208 3D domain; Region: 3D; cl01439 745776006209 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 745776006210 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 745776006211 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 745776006212 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 745776006213 MraW methylase family; Region: Methyltransf_5; cl17771 745776006214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 745776006215 MraZ protein; Region: MraZ; pfam02381 745776006216 MraZ protein; Region: MraZ; pfam02381 745776006217 Protein of unknown function (DUF423); Region: DUF423; pfam04241 745776006218 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 745776006219 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 745776006220 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 745776006221 pseudouridine synthase; Region: TIGR00093 745776006222 active site 745776006223 tRNA pseudouridine synthase B; Provisional; Region: PRK14122 745776006224 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 745776006225 RNA binding site [nucleotide binding]; other site 745776006226 active site 745776006227 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 745776006228 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 745776006229 intersubunit interface [polypeptide binding]; other site 745776006230 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 745776006231 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 745776006232 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 745776006233 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 745776006234 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 745776006235 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 745776006236 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 745776006237 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 745776006238 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 745776006239 putative ligand binding site [chemical binding]; other site 745776006240 EamA-like transporter family; Region: EamA; pfam00892 745776006241 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 745776006242 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 745776006243 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 745776006244 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 745776006245 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745776006246 metal binding site [ion binding]; metal-binding site 745776006247 active site 745776006248 I-site; other site 745776006249 Protein of unknown function (DUF4127); Region: DUF4127; pfam13552 745776006250 Protein of unknown function (DUF4127); Region: DUF4127; pfam13552 745776006251 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 745776006252 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 745776006253 FtsX-like permease family; Region: FtsX; pfam02687 745776006254 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 745776006255 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 745776006256 Walker A/P-loop; other site 745776006257 ATP binding site [chemical binding]; other site 745776006258 Q-loop/lid; other site 745776006259 ABC transporter signature motif; other site 745776006260 Walker B; other site 745776006261 D-loop; other site 745776006262 H-loop/switch region; other site 745776006263 Phosphoglucose isomerase; Region: PGI; pfam00342 745776006264 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 745776006265 active site 745776006266 dimer interface [polypeptide binding]; other site 745776006267 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 745776006268 dimer interface [polypeptide binding]; other site 745776006269 active site 745776006270 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 745776006271 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 745776006272 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 745776006273 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 745776006274 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745776006275 putative substrate translocation pore; other site 745776006276 Major Facilitator Superfamily; Region: MFS_1; pfam07690 745776006277 Phospholipid methyltransferase; Region: PEMT; cl17370 745776006278 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 745776006279 Walker A; other site 745776006280 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 745776006281 catalytic core [active] 745776006282 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 745776006283 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 745776006284 dimerization interface [polypeptide binding]; other site 745776006285 putative ATP binding site [chemical binding]; other site 745776006286 Uncharacterized conserved protein [Function unknown]; Region: COG0398 745776006287 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 745776006288 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 745776006289 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 745776006290 substrate binding pocket [chemical binding]; other site 745776006291 chain length determination region; other site 745776006292 substrate-Mg2+ binding site; other site 745776006293 catalytic residues [active] 745776006294 aspartate-rich region 1; other site 745776006295 active site lid residues [active] 745776006296 aspartate-rich region 2; other site 745776006297 N-formylglutamate amidohydrolase; Region: FGase; cl01522 745776006298 recombination protein F; Provisional; Region: recF; PRK14079 745776006299 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776006300 Walker A/P-loop; other site 745776006301 ATP binding site [chemical binding]; other site 745776006302 Q-loop/lid; other site 745776006303 Protein of unknown function (DUF721); Region: DUF721; pfam05258 745776006304 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 745776006305 homotetramer interface [polypeptide binding]; other site 745776006306 FMN binding site [chemical binding]; other site 745776006307 homodimer contacts [polypeptide binding]; other site 745776006308 putative active site [active] 745776006309 putative substrate binding site [chemical binding]; other site 745776006310 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 745776006311 alanine racemase; Region: alr; TIGR00492 745776006312 dimer interface [polypeptide binding]; other site 745776006313 active site 745776006314 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 745776006315 substrate binding site [chemical binding]; other site 745776006316 catalytic residues [active] 745776006317 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 745776006318 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776006319 active site 745776006320 phosphorylation site [posttranslational modification] 745776006321 intermolecular recognition site; other site 745776006322 dimerization interface [polypeptide binding]; other site 745776006323 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 745776006324 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 745776006325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776006326 ATP binding site [chemical binding]; other site 745776006327 Mg2+ binding site [ion binding]; other site 745776006328 G-X-G motif; other site 745776006329 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 745776006330 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 745776006331 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 745776006332 superoxide dismutase; Provisional; Region: PRK10925 745776006333 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 745776006334 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 745776006335 TPR repeat; Region: TPR_11; pfam13414 745776006336 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 745776006337 TPR motif; other site 745776006338 binding surface 745776006339 TPR repeat; Region: TPR_11; pfam13414 745776006340 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 745776006341 binding surface 745776006342 TPR motif; other site 745776006343 TPR repeat; Region: TPR_11; pfam13414 745776006344 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 745776006345 dephospho-CoA kinase; Region: TIGR00152 745776006346 CoA-binding site [chemical binding]; other site 745776006347 ATP-binding [chemical binding]; other site 745776006348 CTP synthetase; Validated; Region: pyrG; PRK05380 745776006349 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 745776006350 Catalytic site [active] 745776006351 active site 745776006352 UTP binding site [chemical binding]; other site 745776006353 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 745776006354 active site 745776006355 putative oxyanion hole; other site 745776006356 catalytic triad [active] 745776006357 Peptidase family M50; Region: Peptidase_M50; pfam02163 745776006358 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 745776006359 active site 745776006360 putative substrate binding region [chemical binding]; other site 745776006361 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 745776006362 metal binding triad [ion binding]; metal-binding site 745776006363 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 745776006364 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 745776006365 protein binding site [polypeptide binding]; other site 745776006366 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 745776006367 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 745776006368 dimerization interface [polypeptide binding]; other site 745776006369 domain crossover interface; other site 745776006370 redox-dependent activation switch; other site 745776006371 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 745776006372 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 745776006373 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 745776006374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776006375 active site 745776006376 phosphorylation site [posttranslational modification] 745776006377 intermolecular recognition site; other site 745776006378 dimerization interface [polypeptide binding]; other site 745776006379 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 745776006380 DNA binding residues [nucleotide binding] 745776006381 dimerization interface [polypeptide binding]; other site 745776006382 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 745776006383 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 745776006384 GAF domain; Region: GAF_2; pfam13185 745776006385 GAF domain; Region: GAF; pfam01590 745776006386 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 745776006387 Histidine kinase; Region: HisKA_3; pfam07730 745776006388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776006389 ATP binding site [chemical binding]; other site 745776006390 Mg2+ binding site [ion binding]; other site 745776006391 G-X-G motif; other site 745776006392 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 745776006393 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745776006394 metal binding site [ion binding]; metal-binding site 745776006395 active site 745776006396 I-site; other site 745776006397 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 745776006398 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 745776006399 putative ADP-binding pocket [chemical binding]; other site 745776006400 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 745776006401 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 745776006402 active site 745776006403 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 745776006404 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 745776006405 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 745776006406 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 745776006407 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 745776006408 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 745776006409 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 745776006410 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 745776006411 active site 745776006412 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 745776006413 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 745776006414 CoA binding domain; Region: CoA_binding; smart00881 745776006415 Sporulation related domain; Region: SPOR; pfam05036 745776006416 Sporulation related domain; Region: SPOR; pfam05036 745776006417 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 745776006418 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14468 745776006419 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 745776006420 FeS/SAM binding site; other site 745776006421 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 745776006422 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 745776006423 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 745776006424 active site 745776006425 DNA polymerase IV; Validated; Region: PRK02406 745776006426 DNA binding site [nucleotide binding] 745776006427 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 745776006428 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 745776006429 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 745776006430 putative RNA binding site [nucleotide binding]; other site 745776006431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745776006432 S-adenosylmethionine binding site [chemical binding]; other site 745776006433 FOG: WD40 repeat [General function prediction only]; Region: COG2319 745776006434 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 745776006435 structural tetrad; other site 745776006436 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 745776006437 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 745776006438 dimer interface [polypeptide binding]; other site 745776006439 active site 745776006440 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 745776006441 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 745776006442 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 745776006443 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 745776006444 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 745776006445 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 745776006446 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 745776006447 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 745776006448 substrate binding site [chemical binding]; other site 745776006449 oxyanion hole (OAH) forming residues; other site 745776006450 trimer interface [polypeptide binding]; other site 745776006451 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 745776006452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 745776006453 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 745776006454 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776006455 AAA domain; Region: AAA_33; pfam13671 745776006456 Walker A/P-loop; other site 745776006457 ATP binding site [chemical binding]; other site 745776006458 RNA ligase; Region: RNA_ligase; pfam09414 745776006459 RNA ligase, DRB0094 family; Region: RNA_lig_DRB0094; TIGR02306 745776006460 RNA ligase; Region: RNA_ligase; pfam09414 745776006461 UDP-N-acetylmuramoylalanine--D-glutamate ligase; Region: murD; TIGR01087 745776006462 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 745776006463 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 745776006464 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 745776006465 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 745776006466 23S rRNA interface [nucleotide binding]; other site 745776006467 L3 interface [polypeptide binding]; other site 745776006468 Putative esterase; Region: Esterase; pfam00756 745776006469 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 745776006470 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 745776006471 Dehydroquinase class II; Region: DHquinase_II; pfam01220 745776006472 active site 745776006473 trimer interface [polypeptide binding]; other site 745776006474 dimer interface [polypeptide binding]; other site 745776006475 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 745776006476 active site 745776006477 dimer interface [polypeptide binding]; other site 745776006478 metal binding site [ion binding]; metal-binding site 745776006479 shikimate kinase; Provisional; Region: PRK13948 745776006480 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 745776006481 ADP binding site [chemical binding]; other site 745776006482 magnesium binding site [ion binding]; other site 745776006483 putative shikimate binding site; other site 745776006484 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 745776006485 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 745776006486 Tetramer interface [polypeptide binding]; other site 745776006487 active site 745776006488 FMN-binding site [chemical binding]; other site 745776006489 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 745776006490 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 745776006491 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 745776006492 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 745776006493 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 745776006494 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 745776006495 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 745776006496 Cell division protein FtsA; Region: FtsA; pfam14450 745776006497 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 745776006498 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 745776006499 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 745776006500 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 745776006501 lipoyl synthase; Provisional; Region: PRK05481 745776006502 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 745776006503 FeS/SAM binding site; other site 745776006504 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 745776006505 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 745776006506 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 745776006507 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 745776006508 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 745776006509 Glycoprotease family; Region: Peptidase_M22; pfam00814 745776006510 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 745776006511 dimer interface [polypeptide binding]; other site 745776006512 Citrate synthase; Region: Citrate_synt; pfam00285 745776006513 active site 745776006514 coenzyme A binding site [chemical binding]; other site 745776006515 citrylCoA binding site [chemical binding]; other site 745776006516 oxalacetate/citrate binding site [chemical binding]; other site 745776006517 catalytic triad [active] 745776006518 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 745776006519 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 745776006520 Glucose inhibited division protein A; Region: GIDA; pfam01134 745776006521 Uncharacterized conserved protein [Function unknown]; Region: COG1434 745776006522 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 745776006523 putative active site [active] 745776006524 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 745776006525 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 745776006526 putative active site [active] 745776006527 putative FMN binding site [chemical binding]; other site 745776006528 putative substrate binding site [chemical binding]; other site 745776006529 putative catalytic residue [active] 745776006530 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 745776006531 RNA/DNA hybrid binding site [nucleotide binding]; other site 745776006532 active site 745776006533 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 745776006534 [2Fe-2S] cluster binding site [ion binding]; other site 745776006535 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 745776006536 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 745776006537 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 745776006538 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 745776006539 putative acyltransferase; Provisional; Region: PRK05790 745776006540 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 745776006541 dimer interface [polypeptide binding]; other site 745776006542 active site 745776006543 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 745776006544 active site 745776006545 GTP-binding protein LepA; Provisional; Region: PRK05433 745776006546 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 745776006547 GTP/Mg2+ binding site [chemical binding]; other site 745776006548 putative GEF interaction site [polypeptide binding]; other site 745776006549 G1 box; other site 745776006550 Switch I region; other site 745776006551 G2 box; other site 745776006552 G3 box; other site 745776006553 Switch II region; other site 745776006554 G4 box; other site 745776006555 G5 box; other site 745776006556 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 745776006557 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 745776006558 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 745776006559 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 745776006560 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 745776006561 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 745776006562 active site 745776006563 metal binding site [ion binding]; metal-binding site 745776006564 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 745776006565 trimer interface [polypeptide binding]; other site 745776006566 active site 745776006567 Predicted membrane protein [Function unknown]; Region: COG4270 745776006568 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 745776006569 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 745776006570 putative metal binding site [ion binding]; other site 745776006571 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 745776006572 active site 745776006573 metal binding site [ion binding]; metal-binding site 745776006574 Methyltransferase domain; Region: Methyltransf_12; pfam08242 745776006575 S-adenosylmethionine binding site [chemical binding]; other site 745776006576 Putative methyltransferase; Region: Methyltransf_4; cl17290 745776006577 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 745776006578 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 745776006579 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 745776006580 active site 745776006581 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 745776006582 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745776006583 Outer membrane efflux protein; Region: OEP; pfam02321 745776006584 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 745776006585 HlyD family secretion protein; Region: HlyD_3; pfam13437 745776006586 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 745776006587 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 745776006588 conjugal transfer protein TrbI; Provisional; Region: PRK13881 745776006589 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 745776006590 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 745776006591 purine monophosphate binding site [chemical binding]; other site 745776006592 dimer interface [polypeptide binding]; other site 745776006593 putative catalytic residues [active] 745776006594 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 745776006595 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 745776006596 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 745776006597 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 745776006598 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 745776006599 NAD(P) binding pocket [chemical binding]; other site 745776006600 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 745776006601 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 745776006602 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 745776006603 active site 745776006604 Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; cl01558 745776006605 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 745776006606 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 745776006607 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 745776006608 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745776006609 NAD(P) binding site [chemical binding]; other site 745776006610 active site 745776006611 Predicted transcriptional regulators [Transcription]; Region: COG1733 745776006612 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 745776006613 prolyl-tRNA synthetase; Provisional; Region: PRK08661 745776006614 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 745776006615 dimer interface [polypeptide binding]; other site 745776006616 motif 1; other site 745776006617 active site 745776006618 motif 2; other site 745776006619 motif 3; other site 745776006620 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 745776006621 anticodon binding site; other site 745776006622 zinc-binding site [ion binding]; other site 745776006623 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 745776006624 Uncharacterized conserved protein [Function unknown]; Region: COG4850 745776006625 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 745776006626 classical (c) SDRs; Region: SDR_c; cd05233 745776006627 NAD(P) binding site [chemical binding]; other site 745776006628 active site 745776006629 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 745776006630 active site 745776006631 catalytic residues [active] 745776006632 adhesin; Provisional; Region: PRK09752 745776006633 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 745776006634 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 745776006635 DNA binding residues [nucleotide binding] 745776006636 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 745776006637 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 745776006638 amphipathic channel; other site 745776006639 Asn-Pro-Ala signature motifs; other site 745776006640 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 745776006641 homotetramer interface [polypeptide binding]; other site 745776006642 N- and C-terminal domain interface [polypeptide binding]; other site 745776006643 active site 745776006644 glycerol binding site [chemical binding]; other site 745776006645 homodimer interface [polypeptide binding]; other site 745776006646 FBP binding site [chemical binding]; other site 745776006647 MgATP binding site [chemical binding]; other site 745776006648 protein IIAGlc interface [polypeptide binding]; other site 745776006649 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 745776006650 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 745776006651 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 745776006652 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 745776006653 metal binding site [ion binding]; metal-binding site 745776006654 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 745776006655 catalytic triad [active] 745776006656 conserved cis-peptide bond; other site 745776006657 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 745776006658 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 745776006659 NAD binding site [chemical binding]; other site 745776006660 homotetramer interface [polypeptide binding]; other site 745776006661 homodimer interface [polypeptide binding]; other site 745776006662 substrate binding site [chemical binding]; other site 745776006663 active site 745776006664 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 745776006665 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 745776006666 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 745776006667 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745776006668 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 745776006669 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 745776006670 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 745776006671 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 745776006672 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 745776006673 Walker A motif; other site 745776006674 ATP binding site [chemical binding]; other site 745776006675 Walker B motif; other site 745776006676 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 745776006677 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 745776006678 Walker A motif; other site 745776006679 ATP binding site [chemical binding]; other site 745776006680 Walker B motif; other site 745776006681 TrkA-N domain; Region: TrkA_N; pfam02254 745776006682 Protein of unknown function (DUF1012); Region: DUF1012; pfam06241 745776006683 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 745776006684 Found in ATP-dependent protease La (LON); Region: LON; smart00464 745776006685 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745776006686 Walker A motif; other site 745776006687 ATP binding site [chemical binding]; other site 745776006688 Walker B motif; other site 745776006689 arginine finger; other site 745776006690 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 745776006691 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 745776006692 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 745776006693 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 745776006694 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745776006695 Walker A motif; other site 745776006696 ATP binding site [chemical binding]; other site 745776006697 Walker B motif; other site 745776006698 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 745776006699 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 745776006700 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 745776006701 oligomer interface [polypeptide binding]; other site 745776006702 active site residues [active] 745776006703 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 745776006704 dimer interface [polypeptide binding]; other site 745776006705 FMN binding site [chemical binding]; other site 745776006706 Predicted transcriptional regulators [Transcription]; Region: COG1733 745776006707 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 745776006708 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 745776006709 Uncharacterized conserved protein, YhbC family [Function unknown]; Region: COG0782 745776006710 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 745776006711 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193 745776006712 MutS domain III; Region: MutS_III; pfam05192 745776006713 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 745776006714 Walker A/P-loop; other site 745776006715 ATP binding site [chemical binding]; other site 745776006716 Q-loop/lid; other site 745776006717 ABC transporter signature motif; other site 745776006718 Walker B; other site 745776006719 D-loop; other site 745776006720 H-loop/switch region; other site 745776006721 Smr domain; Region: Smr; pfam01713 745776006722 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 745776006723 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 745776006724 putative NAD(P) binding site [chemical binding]; other site 745776006725 active site 745776006726 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 745776006727 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 745776006728 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 745776006729 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 745776006730 RNA binding site [nucleotide binding]; other site 745776006731 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 745776006732 RNA binding site [nucleotide binding]; other site 745776006733 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 745776006734 RNA binding site [nucleotide binding]; other site 745776006735 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 745776006736 RNA binding site [nucleotide binding]; other site 745776006737 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 745776006738 RNA binding site [nucleotide binding]; other site 745776006739 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745776006740 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 745776006741 metal binding site [ion binding]; metal-binding site 745776006742 active site 745776006743 I-site; other site 745776006744 thymidine kinase; Provisional; Region: PRK04296 745776006745 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745776006746 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 745776006747 NAD(P) binding site [chemical binding]; other site 745776006748 active site 745776006749 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 745776006750 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 745776006751 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 745776006752 active site 745776006753 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 745776006754 SpoOM protein; Region: Spo0M; pfam07070 745776006755 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 745776006756 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 745776006757 nucleotide binding site [chemical binding]; other site 745776006758 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 745776006759 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 745776006760 putative NAD(P) binding site [chemical binding]; other site 745776006761 putative active site [active] 745776006762 Ferritin-like domain; Region: Ferritin_2; pfam13668 745776006763 putative anti-sigmaE protein; Provisional; Region: PRK13920 745776006764 Anti-sigma-K factor rskA; Region: RskA; pfam10099 745776006765 RNA polymerase sigma factor; Provisional; Region: PRK11924 745776006766 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 745776006767 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 745776006768 DNA binding residues [nucleotide binding] 745776006769 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 745776006770 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 745776006771 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 745776006772 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 745776006773 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14358 745776006774 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 745776006775 Substrate binding site; other site 745776006776 Mg++ binding site; other site 745776006777 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 745776006778 active site 745776006779 substrate binding site [chemical binding]; other site 745776006780 CoA binding site [chemical binding]; other site 745776006781 prenyltransferase; Provisional; Region: ubiA; PRK13595 745776006782 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 745776006783 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 745776006784 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 745776006785 active site 745776006786 catalytic residues [active] 745776006787 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 745776006788 PA/protease or protease-like domain interface [polypeptide binding]; other site 745776006789 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 745776006790 catalytic residues [active] 745776006791 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 745776006792 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 745776006793 Glutamate binding site [chemical binding]; other site 745776006794 homodimer interface [polypeptide binding]; other site 745776006795 NAD binding site [chemical binding]; other site 745776006796 catalytic residues [active] 745776006797 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 745776006798 Transcriptional regulators [Transcription]; Region: GntR; COG1802 745776006799 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745776006800 DNA-binding site [nucleotide binding]; DNA binding site 745776006801 MgtC family; Region: MgtC; pfam02308 745776006802 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 745776006803 Recombination protein O N terminal; Region: RecO_N; pfam11967 745776006804 Recombination protein O C terminal; Region: RecO_C; pfam02565 745776006805 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 745776006806 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 745776006807 substrate binding pocket [chemical binding]; other site 745776006808 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 745776006809 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 745776006810 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 745776006811 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 745776006812 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 745776006813 putative L-serine binding site [chemical binding]; other site 745776006814 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 745776006815 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 745776006816 Predicted transcriptional regulators [Transcription]; Region: COG1695 745776006817 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 745776006818 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 745776006819 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 745776006820 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 745776006821 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 745776006822 dimer interface [polypeptide binding]; other site 745776006823 putative anticodon binding site; other site 745776006824 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 745776006825 motif 1; other site 745776006826 active site 745776006827 motif 2; other site 745776006828 motif 3; other site 745776006829 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 745776006830 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 745776006831 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 745776006832 FeS/SAM binding site; other site 745776006833 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 745776006834 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 745776006835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776006836 dimer interface [polypeptide binding]; other site 745776006837 conserved gate region; other site 745776006838 putative PBP binding loops; other site 745776006839 ABC-ATPase subunit interface; other site 745776006840 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 745776006841 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776006842 dimer interface [polypeptide binding]; other site 745776006843 conserved gate region; other site 745776006844 putative PBP binding loops; other site 745776006845 ABC-ATPase subunit interface; other site 745776006846 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 745776006847 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 745776006848 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 745776006849 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 745776006850 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 745776006851 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 745776006852 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 745776006853 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 745776006854 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 745776006855 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 745776006856 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 745776006857 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 745776006858 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 745776006859 tRNA; other site 745776006860 putative tRNA binding site [nucleotide binding]; other site 745776006861 putative NADP binding site [chemical binding]; other site 745776006862 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 745776006863 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 745776006864 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 745776006865 active site 745776006866 SAM binding site [chemical binding]; other site 745776006867 homodimer interface [polypeptide binding]; other site 745776006868 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 745776006869 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 745776006870 active site 745776006871 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 745776006872 nudix motif; other site 745776006873 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 745776006874 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 745776006875 cleavage site 745776006876 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 745776006877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776006878 active site 745776006879 phosphorylation site [posttranslational modification] 745776006880 intermolecular recognition site; other site 745776006881 dimerization interface [polypeptide binding]; other site 745776006882 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 745776006883 DNA binding site [nucleotide binding] 745776006884 Predicted membrane protein [Function unknown]; Region: COG2259 745776006885 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 745776006886 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745776006887 Walker A motif; other site 745776006888 ATP binding site [chemical binding]; other site 745776006889 Walker B motif; other site 745776006890 arginine finger; other site 745776006891 Peptidase family M41; Region: Peptidase_M41; pfam01434 745776006892 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 745776006893 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 745776006894 homodimer interface [polypeptide binding]; other site 745776006895 metal binding site [ion binding]; metal-binding site 745776006896 metal-dependent hydrolase; Provisional; Region: PRK13291 745776006897 DinB superfamily; Region: DinB_2; pfam12867 745776006898 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 745776006899 FAD binding domain; Region: FAD_binding_4; pfam01565 745776006900 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745776006901 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 745776006902 substrate binding pocket [chemical binding]; other site 745776006903 membrane-bound complex binding site; other site 745776006904 hinge residues; other site 745776006905 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 745776006906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776006907 dimer interface [polypeptide binding]; other site 745776006908 conserved gate region; other site 745776006909 putative PBP binding loops; other site 745776006910 ABC-ATPase subunit interface; other site 745776006911 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745776006912 non-specific DNA binding site [nucleotide binding]; other site 745776006913 salt bridge; other site 745776006914 sequence-specific DNA binding site [nucleotide binding]; other site 745776006915 Cupin domain; Region: Cupin_2; pfam07883 745776006916 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 745776006917 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 745776006918 Walker A/P-loop; other site 745776006919 ATP binding site [chemical binding]; other site 745776006920 Q-loop/lid; other site 745776006921 ABC transporter signature motif; other site 745776006922 Walker B; other site 745776006923 D-loop; other site 745776006924 H-loop/switch region; other site 745776006925 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 745776006926 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 745776006927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745776006928 homodimer interface [polypeptide binding]; other site 745776006929 catalytic residue [active] 745776006930 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 745776006931 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 745776006932 active site 745776006933 FMN binding site [chemical binding]; other site 745776006934 substrate binding site [chemical binding]; other site 745776006935 putative catalytic residues [active] 745776006936 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 745776006937 MutS domain I; Region: MutS_I; pfam01624 745776006938 MutS domain II; Region: MutS_II; pfam05188 745776006939 MutS domain III; Region: MutS_III; pfam05192 745776006940 MutS domain V; Region: MutS_V; pfam00488 745776006941 Walker A/P-loop; other site 745776006942 ATP binding site [chemical binding]; other site 745776006943 Q-loop/lid; other site 745776006944 ABC transporter signature motif; other site 745776006945 Walker B; other site 745776006946 D-loop; other site 745776006947 H-loop/switch region; other site 745776006948 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 745776006949 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 745776006950 active site 745776006951 HIGH motif; other site 745776006952 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 745776006953 KMSKS motif; other site 745776006954 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 745776006955 tRNA binding surface [nucleotide binding]; other site 745776006956 anticodon binding site; other site 745776006957 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 745776006958 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 745776006959 Zn2+ binding site [ion binding]; other site 745776006960 Mg2+ binding site [ion binding]; other site 745776006961 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 745776006962 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 745776006963 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 745776006964 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 745776006965 DNA binding residues [nucleotide binding] 745776006966 putative dimer interface [polypeptide binding]; other site 745776006967 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 745776006968 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 745776006969 DNA binding residues [nucleotide binding] 745776006970 putative dimer interface [polypeptide binding]; other site 745776006971 threonine dehydratase; Reviewed; Region: PRK09224 745776006972 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 745776006973 tetramer interface [polypeptide binding]; other site 745776006974 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745776006975 catalytic residue [active] 745776006976 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 745776006977 putative Ile/Val binding site [chemical binding]; other site 745776006978 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 745776006979 putative Ile/Val binding site [chemical binding]; other site 745776006980 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 745776006981 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 745776006982 Thymidylate synthase complementing protein; Region: Thy1; cl03630 745776006983 EVE domain; Region: EVE; cl00728 745776006984 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 745776006985 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 745776006986 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 745776006987 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 745776006988 active site 745776006989 catalytic residues [active] 745776006990 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 745776006991 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 745776006992 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 745776006993 PAS fold; Region: PAS_4; pfam08448 745776006994 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 745776006995 putative active site [active] 745776006996 heme pocket [chemical binding]; other site 745776006997 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 745776006998 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745776006999 metal binding site [ion binding]; metal-binding site 745776007000 active site 745776007001 I-site; other site 745776007002 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 745776007003 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 745776007004 Predicted amidohydrolase [General function prediction only]; Region: COG0388 745776007005 active site 745776007006 catalytic triad [active] 745776007007 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 745776007008 Flavoprotein; Region: Flavoprotein; pfam02441 745776007009 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 745776007010 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 745776007011 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 745776007012 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 745776007013 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 745776007014 dimerization interface [polypeptide binding]; other site 745776007015 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745776007016 dimer interface [polypeptide binding]; other site 745776007017 phosphorylation site [posttranslational modification] 745776007018 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776007019 ATP binding site [chemical binding]; other site 745776007020 Mg2+ binding site [ion binding]; other site 745776007021 G-X-G motif; other site 745776007022 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 745776007023 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776007024 active site 745776007025 phosphorylation site [posttranslational modification] 745776007026 intermolecular recognition site; other site 745776007027 dimerization interface [polypeptide binding]; other site 745776007028 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 745776007029 DNA binding site [nucleotide binding] 745776007030 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 745776007031 cyclase homology domain; Region: CHD; cd07302 745776007032 nucleotidyl binding site; other site 745776007033 metal binding site [ion binding]; metal-binding site 745776007034 dimer interface [polypeptide binding]; other site 745776007035 glycogen synthase; Provisional; Region: glgA; PRK00654 745776007036 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 745776007037 ADP-binding pocket [chemical binding]; other site 745776007038 homodimer interface [polypeptide binding]; other site 745776007039 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 745776007040 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 745776007041 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 745776007042 GAF domain; Region: GAF_3; pfam13492 745776007043 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 745776007044 Histidine kinase; Region: HisKA_3; pfam07730 745776007045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776007046 ATP binding site [chemical binding]; other site 745776007047 Mg2+ binding site [ion binding]; other site 745776007048 G-X-G motif; other site 745776007049 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 745776007050 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 745776007051 G1 box; other site 745776007052 GTP/Mg2+ binding site [chemical binding]; other site 745776007053 G2 box; other site 745776007054 Switch I region; other site 745776007055 G3 box; other site 745776007056 Switch II region; other site 745776007057 G4 box; other site 745776007058 G5 box; other site 745776007059 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 745776007060 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 745776007061 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 745776007062 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 745776007063 active site 745776007064 catalytic tetrad [active] 745776007065 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 745776007066 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 745776007067 Walker A/P-loop; other site 745776007068 ATP binding site [chemical binding]; other site 745776007069 Q-loop/lid; other site 745776007070 ABC transporter signature motif; other site 745776007071 Walker B; other site 745776007072 D-loop; other site 745776007073 H-loop/switch region; other site 745776007074 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 745776007075 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 745776007076 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 745776007077 substrate binding site [chemical binding]; other site 745776007078 dimer interface [polypeptide binding]; other site 745776007079 Predicted integral membrane protein [Function unknown]; Region: COG5652 745776007080 MoxR-like ATPases [General function prediction only]; Region: COG0714 745776007081 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745776007082 Walker A motif; other site 745776007083 ATP binding site [chemical binding]; other site 745776007084 Walker B motif; other site 745776007085 arginine finger; other site 745776007086 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 745776007087 Protein of unknown function DUF58; Region: DUF58; pfam01882 745776007088 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 745776007089 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 745776007090 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 745776007091 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 745776007092 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 745776007093 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 745776007094 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 745776007095 Peptidase M16C associated; Region: M16C_assoc; pfam08367 745776007096 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 745776007097 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 745776007098 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 745776007099 Na binding site [ion binding]; other site 745776007100 Protein of unknown function, DUF485; Region: DUF485; cl01231 745776007101 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 745776007102 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 745776007103 FeS/SAM binding site; other site 745776007104 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 745776007105 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 745776007106 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745776007107 DNA-binding site [nucleotide binding]; DNA binding site 745776007108 UTRA domain; Region: UTRA; pfam07702 745776007109 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 745776007110 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 745776007111 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 745776007112 active site 745776007113 catalytic site [active] 745776007114 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 745776007115 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 745776007116 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 745776007117 catalytic site [active] 745776007118 active site 745776007119 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 745776007120 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 745776007121 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 745776007122 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 745776007123 active site 745776007124 catalytic site [active] 745776007125 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 745776007126 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 745776007127 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 745776007128 putative NAD(P) binding site [chemical binding]; other site 745776007129 catalytic Zn binding site [ion binding]; other site 745776007130 structural Zn binding site [ion binding]; other site 745776007131 Type III pantothenate kinase; Region: Pan_kinase; cl17198 745776007132 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 745776007133 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 745776007134 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 745776007135 HlyD family secretion protein; Region: HlyD_3; pfam13437 745776007136 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 745776007137 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 745776007138 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 745776007139 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 745776007140 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 745776007141 Walker A/P-loop; other site 745776007142 ATP binding site [chemical binding]; other site 745776007143 Q-loop/lid; other site 745776007144 ABC transporter signature motif; other site 745776007145 Walker B; other site 745776007146 D-loop; other site 745776007147 H-loop/switch region; other site 745776007148 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 745776007149 FeS assembly protein SufB; Region: sufB; TIGR01980 745776007150 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 745776007151 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 745776007152 active site 745776007153 metal binding site [ion binding]; metal-binding site 745776007154 FeS assembly protein SufD; Region: sufD; TIGR01981 745776007155 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 745776007156 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 745776007157 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 745776007158 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 745776007159 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 745776007160 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 745776007161 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 745776007162 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 745776007163 5S rRNA interface [nucleotide binding]; other site 745776007164 CTC domain interface [polypeptide binding]; other site 745776007165 L16 interface [polypeptide binding]; other site 745776007166 elongation factor P; Validated; Region: PRK00529 745776007167 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 745776007168 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 745776007169 RNA binding site [nucleotide binding]; other site 745776007170 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 745776007171 RNA binding site [nucleotide binding]; other site 745776007172 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 745776007173 carboxyltransferase (CT) interaction site; other site 745776007174 biotinylation site [posttranslational modification]; other site 745776007175 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 745776007176 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 745776007177 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 745776007178 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 745776007179 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 745776007180 substrate binding site [chemical binding]; other site 745776007181 oxyanion hole (OAH) forming residues; other site 745776007182 trimer interface [polypeptide binding]; other site 745776007183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745776007184 NAD(P) binding site [chemical binding]; other site 745776007185 active site 745776007186 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 745776007187 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 745776007188 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 745776007189 active site 745776007190 dimerization interface [polypeptide binding]; other site 745776007191 Fe-S metabolism associated domain; Region: SufE; cl00951 745776007192 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 745776007193 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 745776007194 active site residue [active] 745776007195 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 745776007196 active site residue [active] 745776007197 malate dehydrogenase; Provisional; Region: PRK05442 745776007198 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 745776007199 NAD(P) binding site [chemical binding]; other site 745776007200 dimer interface [polypeptide binding]; other site 745776007201 malate binding site [chemical binding]; other site 745776007202 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 745776007203 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 745776007204 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 745776007205 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 745776007206 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 745776007207 catalytic residues [active] 745776007208 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 745776007209 Predicted thioesterase [General function prediction only]; Region: COG5496 745776007210 malate dehydrogenase; Provisional; Region: PRK13529 745776007211 Malic enzyme, N-terminal domain; Region: malic; pfam00390 745776007212 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 745776007213 NAD(P) binding pocket [chemical binding]; other site 745776007214 Domain of unknown function (DUF4403); Region: DUF4403; pfam14356 745776007215 Uncharacterized conserved protein [Function unknown]; Region: COG0432 745776007216 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cl00254 745776007217 active site 745776007218 dimer interface [polypeptide binding]; other site 745776007219 Predicted metalloprotease [General function prediction only]; Region: COG2321 745776007220 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 745776007221 Protein of unknown function DUF45; Region: DUF45; pfam01863 745776007222 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 745776007223 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 745776007224 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 745776007225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776007226 dimer interface [polypeptide binding]; other site 745776007227 conserved gate region; other site 745776007228 putative PBP binding loops; other site 745776007229 ABC-ATPase subunit interface; other site 745776007230 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 745776007231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776007232 putative PBP binding loops; other site 745776007233 ABC-ATPase subunit interface; other site 745776007234 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 745776007235 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 745776007236 Transcriptional regulators [Transcription]; Region: PurR; COG1609 745776007237 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745776007238 DNA binding site [nucleotide binding] 745776007239 domain linker motif; other site 745776007240 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 745776007241 ligand binding site [chemical binding]; other site 745776007242 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 745776007243 PHP domain; Region: PHP; pfam02811 745776007244 active site 745776007245 PHP Thumb interface [polypeptide binding]; other site 745776007246 metal binding site [ion binding]; metal-binding site 745776007247 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 745776007248 DNA polymerase III subunit alpha; Reviewed; Region: PRK07373 745776007249 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 745776007250 generic binding surface II; other site 745776007251 generic binding surface I; other site 745776007252 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 745776007253 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 745776007254 siderophore binding site; other site 745776007255 Uncharacterized conserved protein [Function unknown]; Region: COG1739 745776007256 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 745776007257 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 745776007258 putative active site [active] 745776007259 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 745776007260 MviN-like protein; Region: MVIN; pfam03023 745776007261 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 745776007262 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745776007263 Walker A motif; other site 745776007264 ATP binding site [chemical binding]; other site 745776007265 Walker B motif; other site 745776007266 arginine finger; other site 745776007267 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 745776007268 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 745776007269 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 745776007270 Cu(I) binding site [ion binding]; other site 745776007271 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 745776007272 Peptidase family M23; Region: Peptidase_M23; pfam01551 745776007273 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 745776007274 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745776007275 metal binding site [ion binding]; metal-binding site 745776007276 active site 745776007277 I-site; other site 745776007278 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 745776007279 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 745776007280 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745776007281 Coenzyme A binding pocket [chemical binding]; other site 745776007282 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 745776007283 nucleoside/Zn binding site; other site 745776007284 dimer interface [polypeptide binding]; other site 745776007285 catalytic motif [active] 745776007286 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745776007287 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 745776007288 metal binding site [ion binding]; metal-binding site 745776007289 active site 745776007290 I-site; other site 745776007291 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 745776007292 oligomerisation interface [polypeptide binding]; other site 745776007293 mobile loop; other site 745776007294 roof hairpin; other site 745776007295 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 745776007296 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 745776007297 ring oligomerisation interface [polypeptide binding]; other site 745776007298 ATP/Mg binding site [chemical binding]; other site 745776007299 stacking interactions; other site 745776007300 hinge regions; other site 745776007301 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 745776007302 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 745776007303 Predicted kinase [General function prediction only]; Region: COG0645 745776007304 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 745776007305 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 745776007306 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 745776007307 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 745776007308 catalytic loop [active] 745776007309 iron binding site [ion binding]; other site 745776007310 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 745776007311 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 745776007312 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 745776007313 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 745776007314 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 745776007315 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 745776007316 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 745776007317 NAD(P) binding site [chemical binding]; other site 745776007318 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 745776007319 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 745776007320 DNA binding residues [nucleotide binding] 745776007321 dimer interface [polypeptide binding]; other site 745776007322 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 745776007323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776007324 dimer interface [polypeptide binding]; other site 745776007325 conserved gate region; other site 745776007326 putative PBP binding loops; other site 745776007327 ABC-ATPase subunit interface; other site 745776007328 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 745776007329 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 745776007330 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 745776007331 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745776007332 substrate binding pocket [chemical binding]; other site 745776007333 membrane-bound complex binding site; other site 745776007334 hinge residues; other site 745776007335 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 745776007336 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 745776007337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575 745776007338 polyphosphate kinase; Provisional; Region: PRK05443 745776007339 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 745776007340 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 745776007341 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 745776007342 putative domain interface [polypeptide binding]; other site 745776007343 putative active site [active] 745776007344 catalytic site [active] 745776007345 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 745776007346 putative domain interface [polypeptide binding]; other site 745776007347 putative active site [active] 745776007348 catalytic site [active] 745776007349 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 745776007350 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 745776007351 dimer interface [polypeptide binding]; other site 745776007352 active site 745776007353 acyl carrier protein; Provisional; Region: acpP; PRK00982 745776007354 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 745776007355 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 745776007356 NAD(P) binding site [chemical binding]; other site 745776007357 homotetramer interface [polypeptide binding]; other site 745776007358 homodimer interface [polypeptide binding]; other site 745776007359 active site 745776007360 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 745776007361 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 745776007362 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 745776007363 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 745776007364 dimer interface [polypeptide binding]; other site 745776007365 active site 745776007366 CoA binding pocket [chemical binding]; other site 745776007367 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 745776007368 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 745776007369 dimer interface [polypeptide binding]; other site 745776007370 active site 745776007371 CoA binding pocket [chemical binding]; other site 745776007372 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]; Region: Tig; COG0544 745776007373 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 745776007374 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 745776007375 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 745776007376 active site 745776007377 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 745776007378 Found in ATP-dependent protease La (LON); Region: LON; smart00464 745776007379 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745776007380 Walker A motif; other site 745776007381 ATP binding site [chemical binding]; other site 745776007382 Walker B motif; other site 745776007383 arginine finger; other site 745776007384 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 745776007385 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 745776007386 Major Facilitator Superfamily; Region: MFS_1; pfam07690 745776007387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745776007388 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 745776007389 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 745776007390 Active site serine [active] 745776007391 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 745776007392 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 745776007393 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 745776007394 alphaNTD - beta interaction site [polypeptide binding]; other site 745776007395 alphaNTD homodimer interface [polypeptide binding]; other site 745776007396 alphaNTD - beta' interaction site [polypeptide binding]; other site 745776007397 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 745776007398 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 745776007399 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 745776007400 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 745776007401 RNA binding surface [nucleotide binding]; other site 745776007402 30S ribosomal protein S11; Validated; Region: PRK05309 745776007403 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 745776007404 30S ribosomal protein S13; Region: bact_S13; TIGR03631 745776007405 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 745776007406 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 745776007407 rRNA binding site [nucleotide binding]; other site 745776007408 predicted 30S ribosome binding site; other site 745776007409 adenylate kinase; Provisional; Region: PRK14527 745776007410 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 745776007411 AMP-binding site [chemical binding]; other site 745776007412 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 745776007413 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 745776007414 SecY translocase; Region: SecY; pfam00344 745776007415 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 745776007416 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 745776007417 23S rRNA binding site [nucleotide binding]; other site 745776007418 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 745776007419 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 745776007420 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 745776007421 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 745776007422 5S rRNA interface [nucleotide binding]; other site 745776007423 23S rRNA interface [nucleotide binding]; other site 745776007424 L5 interface [polypeptide binding]; other site 745776007425 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 745776007426 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 745776007427 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 745776007428 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 745776007429 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 745776007430 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 745776007431 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 745776007432 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 745776007433 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 745776007434 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 745776007435 RNA binding site [nucleotide binding]; other site 745776007436 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 745776007437 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 745776007438 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 745776007439 23S rRNA interface [nucleotide binding]; other site 745776007440 putative translocon interaction site; other site 745776007441 signal recognition particle (SRP54) interaction site; other site 745776007442 L23 interface [polypeptide binding]; other site 745776007443 trigger factor interaction site; other site 745776007444 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 745776007445 23S rRNA interface [nucleotide binding]; other site 745776007446 5S rRNA interface [nucleotide binding]; other site 745776007447 putative antibiotic binding site [chemical binding]; other site 745776007448 L25 interface [polypeptide binding]; other site 745776007449 L27 interface [polypeptide binding]; other site 745776007450 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 745776007451 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 745776007452 G-X-X-G motif; other site 745776007453 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 745776007454 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 745776007455 putative translocon binding site; other site 745776007456 protein-rRNA interface [nucleotide binding]; other site 745776007457 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 745776007458 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 745776007459 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 745776007460 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 745776007461 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 745776007462 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 745776007463 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 745776007464 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 745776007465 elongation factor Tu; Reviewed; Region: PRK00049 745776007466 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 745776007467 G1 box; other site 745776007468 GEF interaction site [polypeptide binding]; other site 745776007469 GTP/Mg2+ binding site [chemical binding]; other site 745776007470 Switch I region; other site 745776007471 G2 box; other site 745776007472 G3 box; other site 745776007473 Switch II region; other site 745776007474 G4 box; other site 745776007475 G5 box; other site 745776007476 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 745776007477 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 745776007478 Antibiotic Binding Site [chemical binding]; other site 745776007479 elongation factor G; Reviewed; Region: PRK00007 745776007480 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 745776007481 G1 box; other site 745776007482 putative GEF interaction site [polypeptide binding]; other site 745776007483 GTP/Mg2+ binding site [chemical binding]; other site 745776007484 Switch I region; other site 745776007485 G2 box; other site 745776007486 G3 box; other site 745776007487 Switch II region; other site 745776007488 G4 box; other site 745776007489 G5 box; other site 745776007490 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 745776007491 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 745776007492 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 745776007493 30S ribosomal protein S7; Validated; Region: PRK05302 745776007494 30S ribosomal protein S12; Validated; Region: rpsL; PRK05163 745776007495 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 745776007496 phosphoglucomutase; Validated; Region: PRK07564 745776007497 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 745776007498 active site 745776007499 substrate binding site [chemical binding]; other site 745776007500 metal binding site [ion binding]; metal-binding site 745776007501 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 745776007502 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 745776007503 putative active site [active] 745776007504 trehalose synthase; Region: treS_nterm; TIGR02456 745776007505 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 745776007506 active site 745776007507 catalytic site [active] 745776007508 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 745776007509 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 745776007510 ribosomal protein L28; Region: L28; TIGR00009 745776007511 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 745776007512 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 745776007513 intersubunit interface [polypeptide binding]; other site 745776007514 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 745776007515 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 745776007516 intersubunit interface [polypeptide binding]; other site 745776007517 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 745776007518 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 745776007519 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 745776007520 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 745776007521 ABC-ATPase subunit interface; other site 745776007522 dimer interface [polypeptide binding]; other site 745776007523 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 745776007524 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 745776007525 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 745776007526 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 745776007527 putative active site pocket [active] 745776007528 dimerization interface [polypeptide binding]; other site 745776007529 putative catalytic residue [active] 745776007530 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 745776007531 16S/18S rRNA binding site [nucleotide binding]; other site 745776007532 S13e-L30e interaction site [polypeptide binding]; other site 745776007533 25S rRNA binding site [nucleotide binding]; other site 745776007534 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 745776007535 active site clefts [active] 745776007536 zinc binding site [ion binding]; other site 745776007537 dimer interface [polypeptide binding]; other site 745776007538 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 745776007539 M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896 745776007540 putative metal binding site [ion binding]; other site 745776007541 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 745776007542 Ca2+ binding site [ion binding]; other site 745776007543 hypothetical protein; Provisional; Region: PRK02395 745776007544 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 745776007545 putative active site [active] 745776007546 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 745776007547 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 745776007548 putative active site [active] 745776007549 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 745776007550 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 745776007551 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 745776007552 active site 745776007553 metal binding site [ion binding]; metal-binding site 745776007554 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 745776007555 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 745776007556 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 745776007557 PHP domain; Region: PHP; pfam02811 745776007558 active site 745776007559 PHP-associated; Region: PHP_C; pfam13263 745776007560 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 745776007561 MoaE interaction surface [polypeptide binding]; other site 745776007562 MoeB interaction surface [polypeptide binding]; other site 745776007563 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 745776007564 MoaE homodimer interface [polypeptide binding]; other site 745776007565 MoaD interaction [polypeptide binding]; other site 745776007566 active site residues [active] 745776007567 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 745776007568 CoenzymeA binding site [chemical binding]; other site 745776007569 subunit interaction site [polypeptide binding]; other site 745776007570 PHB binding site; other site 745776007571 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 745776007572 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 745776007573 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 745776007574 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 745776007575 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 745776007576 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 745776007577 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 745776007578 dimerization domain swap beta strand [polypeptide binding]; other site 745776007579 regulatory protein interface [polypeptide binding]; other site 745776007580 active site 745776007581 regulatory phosphorylation site [posttranslational modification]; other site 745776007582 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 745776007583 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 745776007584 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 745776007585 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 745776007586 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 745776007587 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 745776007588 active site 745776007589 P-loop; other site 745776007590 phosphorylation site [posttranslational modification] 745776007591 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 745776007592 active site 745776007593 phosphorylation site [posttranslational modification] 745776007594 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 745776007595 active site 745776007596 phosphorylation site [posttranslational modification] 745776007597 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 745776007598 dimerization domain swap beta strand [polypeptide binding]; other site 745776007599 regulatory protein interface [polypeptide binding]; other site 745776007600 active site 745776007601 regulatory phosphorylation site [posttranslational modification]; other site 745776007602 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 745776007603 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 745776007604 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 745776007605 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 745776007606 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 745776007607 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 745776007608 putative substrate binding site [chemical binding]; other site 745776007609 putative ATP binding site [chemical binding]; other site 745776007610 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 745776007611 active site 745776007612 P-loop; other site 745776007613 phosphorylation site [posttranslational modification] 745776007614 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 745776007615 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 745776007616 active site 745776007617 P-loop; other site 745776007618 phosphorylation site [posttranslational modification] 745776007619 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 745776007620 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 745776007621 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 745776007622 Walker A motif; other site 745776007623 ATP binding site [chemical binding]; other site 745776007624 Walker B motif; other site 745776007625 Predicted transcriptional regulators [Transcription]; Region: COG1378 745776007626 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 745776007627 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 745776007628 putative active site [active] 745776007629 catalytic site [active] 745776007630 Uncharacterized conserved protein [Function unknown]; Region: COG0327 745776007631 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 745776007632 Thymidylate kinase; Region: Thymidylate_kin; pfam02223 745776007633 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 745776007634 TMP-binding site; other site 745776007635 ATP-binding site [chemical binding]; other site 745776007636 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 745776007637 FOG: CBS domain [General function prediction only]; Region: COG0517 745776007638 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 745776007639 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 745776007640 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 745776007641 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 745776007642 HSP70 interaction site [polypeptide binding]; other site 745776007643 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 745776007644 substrate binding site [polypeptide binding]; other site 745776007645 dimer interface [polypeptide binding]; other site 745776007646 Uncharacterized conserved protein (DUF2132); Region: DUF2132; cl01894 745776007647 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 745776007648 GrpE; Region: GrpE; pfam01025 745776007649 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 745776007650 dimer interface [polypeptide binding]; other site 745776007651 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 745776007652 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 745776007653 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 745776007654 nucleotide binding site [chemical binding]; other site 745776007655 NEF interaction site [polypeptide binding]; other site 745776007656 SBD interface [polypeptide binding]; other site 745776007657 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745776007658 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 745776007659 NAD(P) binding site [chemical binding]; other site 745776007660 active site 745776007661 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 745776007662 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745776007663 Walker A motif; other site 745776007664 ATP binding site [chemical binding]; other site 745776007665 Walker B motif; other site 745776007666 arginine finger; other site 745776007667 Peptidase family M41; Region: Peptidase_M41; pfam01434 745776007668 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 745776007669 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 745776007670 substrate binding pocket [chemical binding]; other site 745776007671 catalytic triad [active] 745776007672 metal-dependent hydrolase; Provisional; Region: PRK00685 745776007673 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 745776007674 Uncharacterized conserved protein [Function unknown]; Region: COG1624 745776007675 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 745776007676 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 745776007677 YbbR-like protein; Region: YbbR; pfam07949 745776007678 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 745776007679 Zn2+ binding site [ion binding]; other site 745776007680 Mg2+ binding site [ion binding]; other site 745776007681 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 745776007682 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 745776007683 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 745776007684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776007685 active site 745776007686 phosphorylation site [posttranslational modification] 745776007687 intermolecular recognition site; other site 745776007688 dimerization interface [polypeptide binding]; other site 745776007689 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 745776007690 DNA binding site [nucleotide binding] 745776007691 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 745776007692 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745776007693 dimer interface [polypeptide binding]; other site 745776007694 phosphorylation site [posttranslational modification] 745776007695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776007696 ATP binding site [chemical binding]; other site 745776007697 Mg2+ binding site [ion binding]; other site 745776007698 G-X-G motif; other site 745776007699 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 745776007700 PhoU domain; Region: PhoU; pfam01895 745776007701 PhoU domain; Region: PhoU; pfam01895 745776007702 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 745776007703 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 745776007704 dimer interface [polypeptide binding]; other site 745776007705 catalytic triad [active] 745776007706 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 745776007707 Putative zinc ribbon domain; Region: DUF164; pfam02591 745776007708 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 745776007709 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 745776007710 minor groove reading motif; other site 745776007711 helix-hairpin-helix signature motif; other site 745776007712 substrate binding pocket [chemical binding]; other site 745776007713 active site 745776007714 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 745776007715 CutA1 divalent ion tolerance protein; Region: CutA1; pfam03091 745776007716 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 745776007717 active site 745776007718 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 745776007719 ROK family; Region: ROK; pfam00480 745776007720 TM2 domain; Region: TM2; pfam05154 745776007721 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 745776007722 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 745776007723 active site 745776007724 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 745776007725 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 745776007726 Domain of unknown function DUF21; Region: DUF21; pfam01595 745776007727 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 745776007728 Transporter associated domain; Region: CorC_HlyC; smart01091 745776007729 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 745776007730 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 745776007731 domain interfaces; other site 745776007732 active site 745776007733 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 745776007734 active site 745776007735 homodimer interface [polypeptide binding]; other site 745776007736 homotetramer interface [polypeptide binding]; other site 745776007737 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 745776007738 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745776007739 non-specific DNA binding site [nucleotide binding]; other site 745776007740 salt bridge; other site 745776007741 sequence-specific DNA binding site [nucleotide binding]; other site 745776007742 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 745776007743 ATP-grasp domain; Region: ATP-grasp; pfam02222 745776007744 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 745776007745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 745776007746 conserved hypothetical protein; Region: TIGR03492 745776007747 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 745776007748 nudix motif; other site 745776007749 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 745776007750 Methyltransferase domain; Region: Methyltransf_23; pfam13489 745776007751 Methyltransferase domain; Region: Methyltransf_18; pfam12847 745776007752 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 745776007753 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 745776007754 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 745776007755 putative tRNA-binding site [nucleotide binding]; other site 745776007756 B3/4 domain; Region: B3_4; pfam03483 745776007757 tRNA synthetase B5 domain; Region: B5; smart00874 745776007758 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 745776007759 dimer interface [polypeptide binding]; other site 745776007760 motif 1; other site 745776007761 motif 3; other site 745776007762 motif 2; other site 745776007763 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 745776007764 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 745776007765 nudix motif; other site 745776007766 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 745776007767 aspartate racemase; Region: asp_race; TIGR00035 745776007768 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 745776007769 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745776007770 Coenzyme A binding pocket [chemical binding]; other site 745776007771 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 745776007772 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 745776007773 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 745776007774 dimer interface [polypeptide binding]; other site 745776007775 motif 1; other site 745776007776 active site 745776007777 motif 2; other site 745776007778 motif 3; other site 745776007779 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 745776007780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776007781 active site 745776007782 phosphorylation site [posttranslational modification] 745776007783 intermolecular recognition site; other site 745776007784 dimerization interface [polypeptide binding]; other site 745776007785 CHASE3 domain; Region: CHASE3; pfam05227 745776007786 HAMP domain; Region: HAMP; pfam00672 745776007787 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745776007788 dimer interface [polypeptide binding]; other site 745776007789 phosphorylation site [posttranslational modification] 745776007790 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776007791 ATP binding site [chemical binding]; other site 745776007792 Mg2+ binding site [ion binding]; other site 745776007793 G-X-G motif; other site 745776007794 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 745776007795 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 745776007796 TrkA-C domain; Region: TrkA_C; pfam02080 745776007797 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 745776007798 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 745776007799 dimer interface [polypeptide binding]; other site 745776007800 active site 745776007801 glycine-pyridoxal phosphate binding site [chemical binding]; other site 745776007802 folate binding site [chemical binding]; other site 745776007803 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 745776007804 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776007805 active site 745776007806 phosphorylation site [posttranslational modification] 745776007807 intermolecular recognition site; other site 745776007808 dimerization interface [polypeptide binding]; other site 745776007809 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 745776007810 DNA binding residues [nucleotide binding] 745776007811 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 745776007812 Histidine kinase; Region: HisKA_3; pfam07730 745776007813 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776007814 ATP binding site [chemical binding]; other site 745776007815 Mg2+ binding site [ion binding]; other site 745776007816 G-X-G motif; other site 745776007817 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 745776007818 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 745776007819 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 745776007820 Walker A/P-loop; other site 745776007821 ATP binding site [chemical binding]; other site 745776007822 Q-loop/lid; other site 745776007823 ABC transporter signature motif; other site 745776007824 Walker B; other site 745776007825 D-loop; other site 745776007826 H-loop/switch region; other site 745776007827 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 745776007828 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 745776007829 active site 745776007830 metal binding site [ion binding]; metal-binding site 745776007831 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 745776007832 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 745776007833 active site 745776007834 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 745776007835 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 745776007836 FeS/SAM binding site; other site 745776007837 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 745776007838 Ligand Binding Site [chemical binding]; other site 745776007839 conserved repeat domain; Region: B_ant_repeat; TIGR01451 745776007840 Domain of unknown function DUF11; Region: DUF11; pfam01345 745776007841 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 745776007842 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 745776007843 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 745776007844 metal ion-dependent adhesion site (MIDAS); other site 745776007845 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 745776007846 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 745776007847 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 745776007848 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 745776007849 dinuclear metal binding motif [ion binding]; other site 745776007850 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 745776007851 active site 745776007852 metal binding site [ion binding]; metal-binding site 745776007853 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745776007854 Coenzyme A binding pocket [chemical binding]; other site 745776007855 Domain of unknown function (DUF305); Region: DUF305; pfam03713 745776007856 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 745776007857 putative homodimer interface [polypeptide binding]; other site 745776007858 putative homotetramer interface [polypeptide binding]; other site 745776007859 allosteric switch controlling residues; other site 745776007860 putative metal binding site [ion binding]; other site 745776007861 putative homodimer-homodimer interface [polypeptide binding]; other site 745776007862 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 745776007863 metal ion-dependent adhesion site (MIDAS); other site 745776007864 MoxR-like ATPases [General function prediction only]; Region: COG0714 745776007865 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 745776007866 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 745776007867 putative hydrophobic ligand binding site [chemical binding]; other site 745776007868 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 745776007869 active site 745776007870 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 745776007871 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 745776007872 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 745776007873 AAA domain; Region: AAA_18; pfam13238 745776007874 ATP-binding site [chemical binding]; other site 745776007875 Sugar specificity; other site 745776007876 Pyrimidine base specificity; other site 745776007877 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 745776007878 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 745776007879 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 745776007880 NAD(P) binding pocket [chemical binding]; other site 745776007881 e3 binding domain; Region: E3_binding; pfam02817 745776007882 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 745776007883 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 745776007884 GDP-binding site [chemical binding]; other site 745776007885 ACT binding site; other site 745776007886 IMP binding site; other site 745776007887 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 745776007888 homodecamer interface [polypeptide binding]; other site 745776007889 GTP cyclohydrolase I; Provisional; Region: PLN03044 745776007890 active site 745776007891 putative catalytic site residues [active] 745776007892 zinc binding site [ion binding]; other site 745776007893 GTP-CH-I/GFRP interaction surface; other site 745776007894 TMAO/DMSO reductase; Reviewed; Region: PRK05363 745776007895 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 745776007896 Moco binding site; other site 745776007897 metal coordination site [ion binding]; other site 745776007898 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 745776007899 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 745776007900 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 745776007901 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 745776007902 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 745776007903 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 745776007904 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 745776007905 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 745776007906 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745776007907 substrate binding pocket [chemical binding]; other site 745776007908 membrane-bound complex binding site; other site 745776007909 hinge residues; other site 745776007910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776007911 dimer interface [polypeptide binding]; other site 745776007912 conserved gate region; other site 745776007913 putative PBP binding loops; other site 745776007914 ABC-ATPase subunit interface; other site 745776007915 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 745776007916 active site 745776007917 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 745776007918 active site 745776007919 hypothetical protein; Provisional; Region: PRK06446 745776007920 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 745776007921 metal binding site [ion binding]; metal-binding site 745776007922 dimer interface [polypeptide binding]; other site 745776007923 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 745776007924 hypothetical protein; Reviewed; Region: PRK09588 745776007925 Cytochrome c; Region: Cytochrom_C; pfam00034 745776007926 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cl01497 745776007927 active site 745776007928 DNA binding site [nucleotide binding] 745776007929 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 745776007930 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 745776007931 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 745776007932 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 745776007933 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 745776007934 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 745776007935 putative ADP-binding pocket [chemical binding]; other site 745776007936 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 745776007937 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 745776007938 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 745776007939 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 745776007940 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 745776007941 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 745776007942 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 745776007943 metal binding site [ion binding]; metal-binding site 745776007944 dimer interface [polypeptide binding]; other site 745776007945 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 745776007946 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 745776007947 trimerization site [polypeptide binding]; other site 745776007948 active site 745776007949 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 745776007950 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 745776007951 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 745776007952 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 745776007953 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 745776007954 ATP binding site [chemical binding]; other site 745776007955 putative Mg++ binding site [ion binding]; other site 745776007956 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 745776007957 nucleotide binding region [chemical binding]; other site 745776007958 ATP-binding site [chemical binding]; other site 745776007959 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 745776007960 AAA ATPase domain; Region: AAA_16; pfam13191 745776007961 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 745776007962 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 745776007963 ligand binding site [chemical binding]; other site 745776007964 Tubulin like; Region: Tubulin_2; pfam13809 745776007965 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 745776007966 Int/Topo IB signature motif; other site 745776007967 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 745776007968 HsdM N-terminal domain; Region: HsdM_N; pfam12161 745776007969 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 745776007970 Methyltransferase domain; Region: Methyltransf_26; pfam13659 745776007971 Protein of unknown function DUF262; Region: DUF262; pfam03235 745776007972 Uncharacterized conserved protein [Function unknown]; Region: COG1479 745776007973 Uncharacterized conserved protein [Function unknown]; Region: COG3472 745776007974 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 745776007975 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 745776007976 Divergent AAA domain; Region: AAA_4; pfam04326 745776007977 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 745776007978 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 745776007979 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 745776007980 GIY-YIG motif/motif A; other site 745776007981 active site 745776007982 catalytic site [active] 745776007983 metal binding site [ion binding]; metal-binding site 745776007984 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 745776007985 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 745776007986 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 745776007987 ATP binding site [chemical binding]; other site 745776007988 putative Mg++ binding site [ion binding]; other site 745776007989 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 745776007990 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336 745776007991 putative ligand binding site [chemical binding]; other site 745776007992 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 745776007993 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 745776007994 TM-ABC transporter signature motif; other site 745776007995 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 745776007996 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 745776007997 TM-ABC transporter signature motif; other site 745776007998 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 745776007999 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 745776008000 Walker A/P-loop; other site 745776008001 ATP binding site [chemical binding]; other site 745776008002 Q-loop/lid; other site 745776008003 ABC transporter signature motif; other site 745776008004 Walker B; other site 745776008005 D-loop; other site 745776008006 H-loop/switch region; other site 745776008007 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 745776008008 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 745776008009 Walker A/P-loop; other site 745776008010 ATP binding site [chemical binding]; other site 745776008011 Q-loop/lid; other site 745776008012 ABC transporter signature motif; other site 745776008013 Walker B; other site 745776008014 D-loop; other site 745776008015 H-loop/switch region; other site 745776008016 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 745776008017 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 745776008018 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 745776008019 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14612 745776008020 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 745776008021 substrate binding site; other site 745776008022 dimer interface; other site 745776008023 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 745776008024 Flavoprotein; Region: Flavoprotein; pfam02441 745776008025 glutaminyl-tRNA synthetase/YqeY domain fusion protein; Provisional; Region: PRK14703 745776008026 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 745776008027 active site 745776008028 HIGH motif; other site 745776008029 nucleotide binding site [chemical binding]; other site 745776008030 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 745776008031 KMSKS motif; other site 745776008032 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 745776008033 GatB domain; Region: GatB_Yqey; smart00845 745776008034 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745776008035 Coenzyme A binding pocket [chemical binding]; other site 745776008036 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 745776008037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776008038 active site 745776008039 phosphorylation site [posttranslational modification] 745776008040 intermolecular recognition site; other site 745776008041 dimerization interface [polypeptide binding]; other site 745776008042 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 745776008043 DNA binding site [nucleotide binding] 745776008044 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 745776008045 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 745776008046 dimerization interface [polypeptide binding]; other site 745776008047 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745776008048 dimer interface [polypeptide binding]; other site 745776008049 phosphorylation site [posttranslational modification] 745776008050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776008051 ATP binding site [chemical binding]; other site 745776008052 Mg2+ binding site [ion binding]; other site 745776008053 G-X-G motif; other site 745776008054 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 745776008055 active site 745776008056 Ferredoxin [Energy production and conversion]; Region: COG1146 745776008057 4Fe-4S binding domain; Region: Fer4; cl02805 745776008058 PCRF domain; Region: PCRF; pfam03462 745776008059 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 745776008060 RF-1 domain; Region: RF-1; pfam00472 745776008061 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 745776008062 catalytic center binding site [active] 745776008063 ATP binding site [chemical binding]; other site 745776008064 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 745776008065 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 745776008066 active site 745776008067 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 745776008068 dihydropteroate synthase; Region: DHPS; TIGR01496 745776008069 substrate binding pocket [chemical binding]; other site 745776008070 dimer interface [polypeptide binding]; other site 745776008071 inhibitor binding site; inhibition site 745776008072 Domain of unknown function (DUF955); Region: DUF955; cl01076 745776008073 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221 745776008074 acyl-CoA binding pocket [chemical binding]; other site 745776008075 CoA binding site [chemical binding]; other site 745776008076 S-ribosylhomocysteinase; Provisional; Region: PRK02260 745776008077 lipoprotein signal peptidase; Provisional; Region: PRK14777 745776008078 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 745776008079 Predicted membrane protein [Function unknown]; Region: COG2261 745776008080 homoserine kinase; Provisional; Region: PRK01212 745776008081 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 745776008082 MMPL family; Region: MMPL; pfam03176 745776008083 MMPL family; Region: MMPL; pfam03176 745776008084 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 745776008085 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 745776008086 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 745776008087 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 745776008088 metal binding site [ion binding]; metal-binding site 745776008089 dimer interface [polypeptide binding]; other site 745776008090 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 745776008091 ArsC family; Region: ArsC; pfam03960 745776008092 catalytic residue [active] 745776008093 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 745776008094 Phosphotransferase enzyme family; Region: APH; pfam01636 745776008095 active site 745776008096 substrate binding site [chemical binding]; other site 745776008097 ATP binding site [chemical binding]; other site 745776008098 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 745776008099 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 745776008100 HflX GTPase family; Region: HflX; cd01878 745776008101 G1 box; other site 745776008102 GTP/Mg2+ binding site [chemical binding]; other site 745776008103 Switch I region; other site 745776008104 G2 box; other site 745776008105 G3 box; other site 745776008106 Switch II region; other site 745776008107 G4 box; other site 745776008108 G5 box; other site 745776008109 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 745776008110 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 745776008111 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745776008112 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 745776008113 putative catalytic site [active] 745776008114 putative metal binding site [ion binding]; other site 745776008115 putative phosphate binding site [ion binding]; other site 745776008116 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 745776008117 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 745776008118 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745776008119 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 745776008120 Walker A motif; other site 745776008121 ATP binding site [chemical binding]; other site 745776008122 Walker B motif; other site 745776008123 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 745776008124 arginine finger; other site 745776008125 Transcriptional regulators [Transcription]; Region: FadR; COG2186 745776008126 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745776008127 DNA-binding site [nucleotide binding]; DNA binding site 745776008128 FCD domain; Region: FCD; pfam07729 745776008129 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 745776008130 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 745776008131 Na binding site [ion binding]; other site 745776008132 putative substrate binding site [chemical binding]; other site 745776008133 allantoinase; Provisional; Region: PRK06189 745776008134 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 745776008135 active site 745776008136 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 745776008137 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 745776008138 putative MPT binding site; other site 745776008139 Competence-damaged protein; Region: CinA; cl00666 745776008140 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 745776008141 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 745776008142 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 745776008143 recombinase A; Provisional; Region: recA; PRK09354 745776008144 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 745776008145 hexamer interface [polypeptide binding]; other site 745776008146 Walker A motif; other site 745776008147 ATP binding site [chemical binding]; other site 745776008148 Walker B motif; other site 745776008149 BioY family; Region: BioY; pfam02632 745776008150 HTH domain; Region: HTH_11; cl17392 745776008151 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 745776008152 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 745776008153 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 745776008154 metal binding site 2 [ion binding]; metal-binding site 745776008155 putative DNA binding helix; other site 745776008156 metal binding site 1 [ion binding]; metal-binding site 745776008157 dimer interface [polypeptide binding]; other site 745776008158 structural Zn2+ binding site [ion binding]; other site 745776008159 short chain dehydrogenase; Provisional; Region: PRK08263 745776008160 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 745776008161 NADP binding site [chemical binding]; other site 745776008162 active site 745776008163 steroid binding site; other site 745776008164 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745776008165 salt bridge; other site 745776008166 non-specific DNA binding site [nucleotide binding]; other site 745776008167 sequence-specific DNA binding site [nucleotide binding]; other site 745776008168 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 745776008169 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 745776008170 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 745776008171 active site 745776008172 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 745776008173 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 745776008174 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745776008175 S-adenosylmethionine binding site [chemical binding]; other site 745776008176 Protein of unknown function (DUF952); Region: DUF952; pfam06108 745776008177 arginine decarboxylase; Provisional; Region: PRK05354 745776008178 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 745776008179 dimer interface [polypeptide binding]; other site 745776008180 active site 745776008181 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 745776008182 catalytic residues [active] 745776008183 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 745776008184 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 745776008185 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 745776008186 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 745776008187 oligomer interface [polypeptide binding]; other site 745776008188 active site 745776008189 metal binding site [ion binding]; metal-binding site 745776008190 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 745776008191 homotrimer interaction site [polypeptide binding]; other site 745776008192 zinc binding site [ion binding]; other site 745776008193 CDP-binding sites; other site 745776008194 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 745776008195 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 745776008196 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 745776008197 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 745776008198 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 745776008199 active site 745776008200 catalytic tetrad [active] 745776008201 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 745776008202 active site 745776008203 Low molecular weight phosphatase family; Region: LMWPc; cd00115 745776008204 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 745776008205 active site 745776008206 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 745776008207 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 745776008208 G-X-X-G motif; other site 745776008209 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 745776008210 RxxxH motif; other site 745776008211 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 745776008212 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 745776008213 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 745776008214 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 745776008215 ATP binding site [chemical binding]; other site 745776008216 active site 745776008217 substrate binding site [chemical binding]; other site 745776008218 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 745776008219 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 745776008220 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 745776008221 putative active site [active] 745776008222 catalytic triad [active] 745776008223 DinB superfamily; Region: DinB_2; pfam12867 745776008224 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 745776008225 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 745776008226 dimerization interface [polypeptide binding]; other site 745776008227 ATP binding site [chemical binding]; other site 745776008228 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 745776008229 dimerization interface [polypeptide binding]; other site 745776008230 ATP binding site [chemical binding]; other site 745776008231 amidophosphoribosyltransferase; Region: purF; TIGR01134 745776008232 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 745776008233 active site 745776008234 tetramer interface [polypeptide binding]; other site 745776008235 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 745776008236 active site 745776008237 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 745776008238 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745776008239 motif II; other site 745776008240 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 745776008241 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 745776008242 Cytochrome P450; Region: p450; cl12078 745776008243 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 745776008244 enterobactin exporter EntS; Provisional; Region: PRK10489 745776008245 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 745776008246 active site 745776008247 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 745776008248 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 745776008249 putative acyl-acceptor binding pocket; other site 745776008250 Protein of unknown function (DUF422); Region: DUF422; pfam04240 745776008251 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 745776008252 nudix motif; other site 745776008253 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 745776008254 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 745776008255 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 745776008256 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 745776008257 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 745776008258 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776008259 Walker A/P-loop; other site 745776008260 ATP binding site [chemical binding]; other site 745776008261 Q-loop/lid; other site 745776008262 ABC transporter signature motif; other site 745776008263 Walker B; other site 745776008264 D-loop; other site 745776008265 H-loop/switch region; other site 745776008266 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 745776008267 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 745776008268 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776008269 Walker A/P-loop; other site 745776008270 ATP binding site [chemical binding]; other site 745776008271 Q-loop/lid; other site 745776008272 ABC transporter signature motif; other site 745776008273 Walker B; other site 745776008274 D-loop; other site 745776008275 H-loop/switch region; other site 745776008276 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 745776008277 replicative DNA helicase; Region: DnaB; TIGR00665 745776008278 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 745776008279 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 745776008280 Walker A motif; other site 745776008281 ATP binding site [chemical binding]; other site 745776008282 Walker B motif; other site 745776008283 DNA binding loops [nucleotide binding] 745776008284 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 745776008285 nudix motif; other site 745776008286 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745776008287 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 745776008288 ATP cone domain; Region: ATP-cone; pfam03477 745776008289 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 745776008290 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 745776008291 putative acyl-acceptor binding pocket; other site 745776008292 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 745776008293 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 745776008294 Phenylacetic acid degradation B; Region: PaaB; cl01371 745776008295 Phenylacetic acid degradation B; Region: PaaB; cl01371 745776008296 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 745776008297 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 745776008298 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 745776008299 Predicted membrane protein [Function unknown]; Region: COG2860 745776008300 UPF0126 domain; Region: UPF0126; pfam03458 745776008301 UPF0126 domain; Region: UPF0126; pfam03458 745776008302 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 745776008303 putative cation:proton antiport protein; Provisional; Region: PRK10669 745776008304 TrkA-N domain; Region: TrkA_N; pfam02254 745776008305 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 745776008306 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 745776008307 Uncharacterized conserved protein [Function unknown]; Region: COG2013 745776008308 BCS1 N terminal; Region: BCS1_N; cl07381 745776008309 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 745776008310 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745776008311 Walker A motif; other site 745776008312 ATP binding site [chemical binding]; other site 745776008313 arginine finger; other site 745776008314 EamA-like transporter family; Region: EamA; pfam00892 745776008315 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 745776008316 EamA-like transporter family; Region: EamA; pfam00892 745776008317 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 745776008318 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 745776008319 Walker A/P-loop; other site 745776008320 ATP binding site [chemical binding]; other site 745776008321 Q-loop/lid; other site 745776008322 ABC transporter signature motif; other site 745776008323 Walker B; other site 745776008324 D-loop; other site 745776008325 H-loop/switch region; other site 745776008326 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 745776008327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776008328 dimer interface [polypeptide binding]; other site 745776008329 conserved gate region; other site 745776008330 ABC-ATPase subunit interface; other site 745776008331 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 745776008332 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 745776008333 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 745776008334 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 745776008335 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 745776008336 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_37; cd04696 745776008337 nudix motif; other site 745776008338 classical (c) SDRs; Region: SDR_c; cd05233 745776008339 NAD(P) binding site [chemical binding]; other site 745776008340 active site 745776008341 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 745776008342 endonuclease III; Region: ENDO3c; smart00478 745776008343 minor groove reading motif; other site 745776008344 helix-hairpin-helix signature motif; other site 745776008345 substrate binding pocket [chemical binding]; other site 745776008346 active site 745776008347 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 745776008348 Exonuclease VII small subunit [DNA replication, recombination, and repair]; Region: XseB; COG1722 745776008349 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 745776008350 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 745776008351 putative acyl-acceptor binding pocket; other site 745776008352 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 745776008353 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 745776008354 ABC-ATPase subunit interface; other site 745776008355 dimer interface [polypeptide binding]; other site 745776008356 putative PBP binding regions; other site 745776008357 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 745776008358 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 745776008359 Walker A/P-loop; other site 745776008360 ATP binding site [chemical binding]; other site 745776008361 Q-loop/lid; other site 745776008362 ABC transporter signature motif; other site 745776008363 Walker B; other site 745776008364 D-loop; other site 745776008365 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 745776008366 dimer interface [polypeptide binding]; other site 745776008367 [2Fe-2S] cluster binding site [ion binding]; other site 745776008368 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 745776008369 putative heme binding pocket [chemical binding]; other site 745776008370 HRDC domain; Region: HRDC; pfam00570 745776008371 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14835 745776008372 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 745776008373 catalytic residue [active] 745776008374 putative FPP diphosphate binding site; other site 745776008375 putative FPP binding hydrophobic cleft; other site 745776008376 dimer interface [polypeptide binding]; other site 745776008377 putative IPP diphosphate binding site; other site 745776008378 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 745776008379 endonuclease III; Region: ENDO3c; smart00478 745776008380 minor groove reading motif; other site 745776008381 helix-hairpin-helix signature motif; other site 745776008382 substrate binding pocket [chemical binding]; other site 745776008383 active site 745776008384 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 745776008385 DNA binding and oxoG recognition site [nucleotide binding] 745776008386 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 745776008387 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745776008388 Coenzyme A binding pocket [chemical binding]; other site 745776008389 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 745776008390 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 745776008391 NAD binding site [chemical binding]; other site 745776008392 homodimer interface [polypeptide binding]; other site 745776008393 active site 745776008394 substrate binding site [chemical binding]; other site 745776008395 Transcriptional regulators [Transcription]; Region: PurR; COG1609 745776008396 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745776008397 DNA binding site [nucleotide binding] 745776008398 domain linker motif; other site 745776008399 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 745776008400 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 745776008401 TAP-like protein; Region: Abhydrolase_4; pfam08386 745776008402 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 745776008403 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 745776008404 Sulfate transporter family; Region: Sulfate_transp; pfam00916 745776008405 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 745776008406 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 745776008407 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 745776008408 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 745776008409 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 745776008410 Peptidase family M23; Region: Peptidase_M23; pfam01551 745776008411 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 745776008412 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 745776008413 active site 745776008414 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 745776008415 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 745776008416 active site 745776008417 metal binding site [ion binding]; metal-binding site 745776008418 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 745776008419 Peptidase S8 family domain, uncharacterized subfamily 5; Region: Peptidases_S8_5; cd07489 745776008420 active site 745776008421 catalytic triad [active] 745776008422 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 745776008423 PA/protease or protease-like domain interface [polypeptide binding]; other site 745776008424 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 745776008425 catalytic residues [active] 745776008426 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 745776008427 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 745776008428 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 745776008429 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 745776008430 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 745776008431 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 745776008432 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 745776008433 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 745776008434 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 745776008435 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 745776008436 GTPase CgtA; Reviewed; Region: obgE; PRK12297 745776008437 GTP1/OBG; Region: GTP1_OBG; pfam01018 745776008438 Obg GTPase; Region: Obg; cd01898 745776008439 G1 box; other site 745776008440 GTP/Mg2+ binding site [chemical binding]; other site 745776008441 Switch I region; other site 745776008442 G2 box; other site 745776008443 G3 box; other site 745776008444 Switch II region; other site 745776008445 G4 box; other site 745776008446 G5 box; other site 745776008447 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 745776008448 Protein of unknown function (DUF418); Region: DUF418; cl12135 745776008449 Protein of unknown function (DUF418); Region: DUF418; pfam04235 745776008450 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 745776008451 putative ADP-ribose binding site [chemical binding]; other site 745776008452 putative active site [active] 745776008453 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 745776008454 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 745776008455 catalytic site [active] 745776008456 G-X2-G-X-G-K; other site 745776008457 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 745776008458 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 745776008459 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 745776008460 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 745776008461 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 745776008462 TPP-binding site [chemical binding]; other site 745776008463 dimer interface [polypeptide binding]; other site 745776008464 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 745776008465 PYR/PP interface [polypeptide binding]; other site 745776008466 dimer interface [polypeptide binding]; other site 745776008467 TPP binding site [chemical binding]; other site 745776008468 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 745776008469 Family of unknown function (DUF633); Region: DUF633; pfam04816 745776008470 Predicted membrane protein [Function unknown]; Region: COG2862 745776008471 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 745776008472 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 745776008473 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 745776008474 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 745776008475 active site 745776008476 HIGH motif; other site 745776008477 dimer interface [polypeptide binding]; other site 745776008478 KMSKS motif; other site 745776008479 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 745776008480 RNA binding surface [nucleotide binding]; other site 745776008481 Flagellin N-methylase; Region: FliB; cl00497 745776008482 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 745776008483 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 745776008484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745776008485 homodimer interface [polypeptide binding]; other site 745776008486 catalytic residue [active] 745776008487 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 745776008488 KH domain; Region: KH_1; pfam00013 745776008489 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 745776008490 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 745776008491 Zn2+ binding site [ion binding]; other site 745776008492 Mg2+ binding site [ion binding]; other site 745776008493 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 745776008494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776008495 active site 745776008496 phosphorylation site [posttranslational modification] 745776008497 intermolecular recognition site; other site 745776008498 dimerization interface [polypeptide binding]; other site 745776008499 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 745776008500 DNA binding site [nucleotide binding] 745776008501 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 745776008502 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 745776008503 dimer interface [polypeptide binding]; other site 745776008504 phosphorylation site [posttranslational modification] 745776008505 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776008506 G-X-G motif; other site 745776008507 DNA protecting protein DprA; Region: dprA; TIGR00732 745776008508 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 745776008509 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745776008510 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745776008511 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 745776008512 dimerization interface [polypeptide binding]; other site 745776008513 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 745776008514 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 745776008515 active site 745776008516 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 745776008517 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 745776008518 Helix-turn-helix domain; Region: HTH_17; cl17695 745776008519 PIN domain; Region: PIN_3; cl17397 745776008520 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 745776008521 PRTRC system protein E; Region: PRTRC_E; TIGR03741 745776008522 Prokaryotic Ubiquitin; Region: Prok_Ub; cl14020 745776008523 Prokaryotic E2 family D; Region: Prok-E2_D; cl14019 745776008524 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 745776008525 Family description; Region: UvrD_C_2; pfam13538 745776008526 FeoC like transcriptional regulator; Region: FeoC; cl17677 745776008527 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 745776008528 IHF dimer interface [polypeptide binding]; other site 745776008529 IHF - DNA interface [nucleotide binding]; other site 745776008530 Protein of unknown function DUF91; Region: DUF91; cl00709 745776008531 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 745776008532 ATP binding site [chemical binding]; other site 745776008533 substrate interface [chemical binding]; other site 745776008534 Prokaryotic E2 family D; Region: Prok-E2_D; cl14019 745776008535 phosphodiesterase; Provisional; Region: PRK12704 745776008536 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 745776008537 RNA/DNA hybrid binding site [nucleotide binding]; other site 745776008538 active site 745776008539 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 745776008540 Integrase core domain; Region: rve_3; cl15866 745776008541 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 745776008542 Transposase; Region: HTH_Tnp_1; cl17663 745776008543 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 745776008544 putative heme binding pocket [chemical binding]; other site 745776008545 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 745776008546 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 745776008547 putative NAD(P) binding site [chemical binding]; other site 745776008548 putative substrate binding site [chemical binding]; other site 745776008549 catalytic Zn binding site [ion binding]; other site 745776008550 structural Zn binding site [ion binding]; other site 745776008551 dimer interface [polypeptide binding]; other site 745776008552 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 745776008553 dimerization interface [polypeptide binding]; other site 745776008554 putative DNA binding site [nucleotide binding]; other site 745776008555 putative Zn2+ binding site [ion binding]; other site 745776008556 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745776008557 Coenzyme A binding pocket [chemical binding]; other site 745776008558 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 745776008559 Transcriptional regulators [Transcription]; Region: MarR; COG1846 745776008560 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 745776008561 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 745776008562 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 745776008563 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 745776008564 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 745776008565 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 745776008566 arsenical pump membrane protein; Provisional; Region: PRK15445 745776008567 transmembrane helices; other site 745776008568 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 745776008569 Low molecular weight phosphatase family; Region: LMWPc; cd00115 745776008570 active site 745776008571 DDE superfamily endonuclease; Region: DDE_3; pfam13358 745776008572 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 745776008573 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 745776008574 DDE superfamily endonuclease; Region: DDE_3; pfam13358 745776008575 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 745776008576 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745776008577 DNA-binding site [nucleotide binding]; DNA binding site 745776008578 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 745776008579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745776008580 homodimer interface [polypeptide binding]; other site 745776008581 catalytic residue [active] 745776008582 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 745776008583 DDE superfamily endonuclease; Region: DDE_5; cl17874 745776008584 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 745776008585 DdrB-like protein; Region: DdrB; pfam12747 745776008586 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 745776008587 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 745776008588 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 745776008589 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 745776008590 Cytochrome c553 [Energy production and conversion]; Region: COG2863 745776008591 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 745776008592 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 745776008593 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 745776008594 Dimer interface [polypeptide binding]; other site 745776008595 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745776008596 dimer interface [polypeptide binding]; other site 745776008597 phosphorylation site [posttranslational modification] 745776008598 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776008599 ATP binding site [chemical binding]; other site 745776008600 Mg2+ binding site [ion binding]; other site 745776008601 G-X-G motif; other site 745776008602 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745776008603 Predicted ATPase [General function prediction only]; Region: COG3903 745776008604 Walker A motif; other site 745776008605 ATP binding site [chemical binding]; other site 745776008606 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 745776008607 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 745776008608 DNA binding residues [nucleotide binding] 745776008609 dimerization interface [polypeptide binding]; other site 745776008610 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 745776008611 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 745776008612 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 745776008613 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 745776008614 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 745776008615 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 745776008616 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 745776008617 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 745776008618 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_7; cd06316 745776008619 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 745776008620 putative ligand binding site [chemical binding]; other site 745776008621 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 745776008622 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 745776008623 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 745776008624 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 745776008625 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 745776008626 Walker A/P-loop; other site 745776008627 ATP binding site [chemical binding]; other site 745776008628 Q-loop/lid; other site 745776008629 ABC transporter signature motif; other site 745776008630 Walker B; other site 745776008631 D-loop; other site 745776008632 H-loop/switch region; other site 745776008633 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 745776008634 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 745776008635 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 745776008636 TM-ABC transporter signature motif; other site 745776008637 Uncharacterized conserved protein [Function unknown]; Region: COG1359 745776008638 DDE superfamily endonuclease; Region: DDE_5; cl17874 745776008639 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 745776008640 DNA topoisomerase I, bacterial; Region: topA_bact; TIGR01051 745776008641 active site 745776008642 interdomain interaction site; other site 745776008643 putative metal-binding site [ion binding]; other site 745776008644 nucleotide binding site [chemical binding]; other site 745776008645 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 745776008646 domain I; other site 745776008647 DNA binding groove [nucleotide binding] 745776008648 phosphate binding site [ion binding]; other site 745776008649 domain II; other site 745776008650 domain III; other site 745776008651 nucleotide binding site [chemical binding]; other site 745776008652 catalytic site [active] 745776008653 domain IV; other site 745776008654 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 745776008655 DNA polymerase type-B family; Region: POLBc; smart00486 745776008656 active site 745776008657 catalytic site [active] 745776008658 substrate binding site [chemical binding]; other site 745776008659 putative transposase OrfB; Reviewed; Region: PHA02517 745776008660 Integrase core domain; Region: rve; pfam00665 745776008661 Integrase core domain; Region: rve_3; pfam13683 745776008662 Transposase; Region: HTH_Tnp_1; pfam01527 745776008663 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 745776008664 CheB methylesterase; Region: CheB_methylest; pfam01339 745776008665 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 745776008666 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 745776008667 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 745776008668 PAS domain; Region: PAS_10; pfam13596 745776008669 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 745776008670 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 745776008671 putative active site [active] 745776008672 heme pocket [chemical binding]; other site 745776008673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776008674 ATP binding site [chemical binding]; other site 745776008675 Mg2+ binding site [ion binding]; other site 745776008676 G-X-G motif; other site 745776008677 CheB methylesterase; Region: CheB_methylest; pfam01339 745776008678 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 745776008679 PAS domain; Region: PAS_9; pfam13426 745776008680 putative active site [active] 745776008681 heme pocket [chemical binding]; other site 745776008682 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 745776008683 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745776008684 metal binding site [ion binding]; metal-binding site 745776008685 active site 745776008686 I-site; other site 745776008687 HTH-like domain; Region: HTH_21; pfam13276 745776008688 Integrase core domain; Region: rve; pfam00665 745776008689 Integrase core domain; Region: rve_3; pfam13683 745776008690 Transposase; Region: HTH_Tnp_1; cl17663 745776008691 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 745776008692 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 745776008693 active site 745776008694 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 745776008695 Transposase; Region: HTH_Tnp_1; pfam01527 745776008696 HTH-like domain; Region: HTH_21; pfam13276 745776008697 Integrase core domain; Region: rve; pfam00665 745776008698 Integrase core domain; Region: rve_3; pfam13683 745776008699 DDE superfamily endonuclease; Region: DDE_4; cl17710 745776008700 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 745776008701 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 745776008702 antitoxin MqsA for MqsR toxin; Region: MqsA; cl15819 745776008703 DDE superfamily endonuclease; Region: DDE_5; pfam13546 745776008704 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 745776008705 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 745776008706 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 745776008707 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 745776008708 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 745776008709 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 745776008710 active site 745776008711 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 745776008712 MarR family; Region: MarR_2; pfam12802 745776008713 CHAT domain; Region: CHAT; cl17868 745776008714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719 745776008715 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 745776008716 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 745776008717 ATP binding site [chemical binding]; other site 745776008718 putative Mg++ binding site [ion binding]; other site 745776008719 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 745776008720 nucleotide binding region [chemical binding]; other site 745776008721 ATP-binding site [chemical binding]; other site 745776008722 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 745776008723 HRDC domain; Region: HRDC; pfam00570 745776008724 HRDC domain; Region: HRDC; pfam00570 745776008725 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745776008726 non-specific DNA binding site [nucleotide binding]; other site 745776008727 salt bridge; other site 745776008728 sequence-specific DNA binding site [nucleotide binding]; other site 745776008729 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 745776008730 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 745776008731 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 745776008732 AAA domain; Region: AAA_30; pfam13604 745776008733 Family description; Region: UvrD_C_2; pfam13538 745776008734 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 745776008735 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 745776008736 Exoribonuclease II [Transcription]; Region: Rnb; COG4776 745776008737 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; cl01017 745776008738 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 745776008739 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 745776008740 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 745776008741 Walker A motif; other site 745776008742 ATP binding site [chemical binding]; other site 745776008743 Walker B motif; other site 745776008744 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 745776008745 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 745776008746 Walker A motif; other site 745776008747 ATP binding site [chemical binding]; other site 745776008748 Walker B motif; other site 745776008749 Pilus assembly protein, PilO; Region: PilO; cl01234 745776008750 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 745776008751 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 745776008752 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 745776008753 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 745776008754 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 745776008755 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 745776008756 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 745776008757 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 745776008758 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 745776008759 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 745776008760 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 745776008761 CRISPR-associated negative auto-regulator DevR/Csa2; Region: DevR; pfam01905 745776008762 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 745776008763 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 745776008764 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 745776008765 Predicted transcriptional regulator [Transcription]; Region: COG2378 745776008766 HTH domain; Region: HTH_11; cl17392 745776008767 WYL domain; Region: WYL; pfam13280 745776008768 potential frameshift: common BLAST hit: gi|94986296|ref|YP_605660.1| transposase, IS4 745776008769 DDE superfamily endonuclease; Region: DDE_4; cl17710 745776008770 DDE superfamily endonuclease; Region: DDE_4; cl17710 745776008771 Beta-Casp domain; Region: Beta-Casp; cl12567 745776008772 potential frameshift: common BLAST hit: gi|226355522|ref|YP_002785262.1| transposase 745776008773 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 745776008774 Protein of unknown function (DUF497); Region: DUF497; cl01108 745776008775 Protein of unknown function (DUF3680); Region: DUF3680; pfam12441 745776008776 TROVE domain; Region: TROVE; pfam05731 745776008777 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 745776008778 metal ion-dependent adhesion site (MIDAS); other site 745776008779 DDE superfamily endonuclease; Region: DDE_5; cl17874 745776008780 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 745776008781 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 745776008782 DDE superfamily endonuclease; Region: DDE_5; cl17874 745776008783 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 745776008784 Replication initiator protein A; Region: RPA; cl17860 745776008785 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 745776008786 putative active site [active] 745776008787 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 745776008788 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 745776008789 DNA-binding residues [nucleotide binding]; DNA binding site 745776008790 nucleotide binding site [chemical binding]; other site 745776008791 polymerase nucleotide-binding site; other site 745776008792 primase nucleotide-binding site [nucleotide binding]; other site 745776008793 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 745776008794 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 745776008795 dimer interface [polypeptide binding]; other site 745776008796 ssDNA binding site [nucleotide binding]; other site 745776008797 tetramer (dimer of dimers) interface [polypeptide binding]; other site 745776008798 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 745776008799 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 745776008800 dimer interface [polypeptide binding]; other site 745776008801 ssDNA binding site [nucleotide binding]; other site 745776008802 tetramer (dimer of dimers) interface [polypeptide binding]; other site 745776008803 transcription elongation factor GreA; Region: greA; TIGR01462 745776008804 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 745776008805 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 745776008806 AAA-like domain; Region: AAA_10; pfam12846 745776008807 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 745776008808 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 745776008809 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 745776008810 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776008811 Walker A/P-loop; other site 745776008812 ATP binding site [chemical binding]; other site 745776008813 Q-loop/lid; other site 745776008814 ABC transporter signature motif; other site 745776008815 Walker B; other site 745776008816 H-loop/switch region; other site 745776008817 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 745776008818 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 745776008819 generic binding surface II; other site 745776008820 generic binding surface I; other site 745776008821 Domain of unknown function (DUF4326); Region: DUF4326; pfam14216 745776008822 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 745776008823 DDE superfamily endonuclease; Region: DDE_4; pfam13359 745776008824 fimbrial outer membrane usher protein PefC; Provisional; Region: PRK15213 745776008825 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 745776008826 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 745776008827 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 745776008828 DDE superfamily endonuclease; Region: DDE_4; cl17710 745776008829 DDE superfamily endonuclease; Region: DDE_5; cl17874 745776008830 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 745776008831 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 745776008832 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 745776008833 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 745776008834 Predicted transporter component [General function prediction only]; Region: COG2391 745776008835 Sulphur transport; Region: Sulf_transp; pfam04143 745776008836 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 745776008837 Predicted transporter component [General function prediction only]; Region: COG2391 745776008838 Sulphur transport; Region: Sulf_transp; pfam04143 745776008839 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 745776008840 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 745776008841 active site residue [active] 745776008842 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 745776008843 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 745776008844 active site residue [active] 745776008845 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 745776008846 putative homodimer interface [polypeptide binding]; other site 745776008847 putative homotetramer interface [polypeptide binding]; other site 745776008848 putative allosteric switch controlling residues; other site 745776008849 putative metal binding site [ion binding]; other site 745776008850 putative homodimer-homodimer interface [polypeptide binding]; other site 745776008851 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 745776008852 dimerization interface [polypeptide binding]; other site 745776008853 putative DNA binding site [nucleotide binding]; other site 745776008854 putative Zn2+ binding site [ion binding]; other site 745776008855 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 745776008856 Low molecular weight phosphatase family; Region: LMWPc; cd00115 745776008857 active site 745776008858 potential frameshift: common BLAST hit: gi|94986304|ref|YP_605668.1| transposase, IS4 745776008859 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 745776008860 Active site serine [active] 745776008861 H+ Antiporter protein; Region: 2A0121; TIGR00900 745776008862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745776008863 putative substrate translocation pore; other site 745776008864 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 745776008865 putative hydrophobic ligand binding site [chemical binding]; other site 745776008866 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 745776008867 phosphoenolpyruvate synthase; Validated; Region: PRK06464 745776008868 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 745776008869 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 745776008870 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 745776008871 Uncharacterized conserved protein [Function unknown]; Region: COG1556 745776008872 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 745776008873 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 745776008874 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 745776008875 Cysteine-rich domain; Region: CCG; pfam02754 745776008876 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 745776008877 Cysteine-rich domain; Region: CCG; pfam02754 745776008878 L-lactate permease; Region: Lactate_perm; cl00701 745776008879 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 745776008880 Transcriptional regulators [Transcription]; Region: GntR; COG1802 745776008881 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745776008882 DNA-binding site [nucleotide binding]; DNA binding site 745776008883 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 745776008884 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 745776008885 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 745776008886 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 745776008887 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 745776008888 Tetratricopeptide repeat; Region: TPR_12; pfam13424 745776008889 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 745776008890 TPR motif; other site 745776008891 binding surface 745776008892 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 745776008893 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 745776008894 active site 745776008895 catalytic residues [active] 745776008896 Transcriptional regulators [Transcription]; Region: PurR; COG1609 745776008897 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 745776008898 dimerization interface [polypeptide binding]; other site 745776008899 ligand binding site [chemical binding]; other site 745776008900 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 745776008901 hypothetical protein; Provisional; Region: PRK11622 745776008902 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 745776008903 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776008904 Walker A/P-loop; other site 745776008905 ATP binding site [chemical binding]; other site 745776008906 Q-loop/lid; other site 745776008907 ABC transporter signature motif; other site 745776008908 Walker B; other site 745776008909 D-loop; other site 745776008910 H-loop/switch region; other site 745776008911 TOBE domain; Region: TOBE_2; pfam08402 745776008912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776008913 dimer interface [polypeptide binding]; other site 745776008914 conserved gate region; other site 745776008915 putative PBP binding loops; other site 745776008916 ABC-ATPase subunit interface; other site 745776008917 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 745776008918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776008919 dimer interface [polypeptide binding]; other site 745776008920 conserved gate region; other site 745776008921 putative PBP binding loops; other site 745776008922 ABC-ATPase subunit interface; other site 745776008923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255 745776008924 Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975 745776008925 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cl17565 745776008926 putative metal binding site [ion binding]; other site 745776008927 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 745776008928 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 745776008929 Homeodomain-like domain; Region: HTH_23; pfam13384 745776008930 Winged helix-turn helix; Region: HTH_29; pfam13551 745776008931 Homeodomain-like domain; Region: HTH_32; pfam13565 745776008932 Integrase core domain; Region: rve; pfam00665 745776008933 Integrase core domain; Region: rve_3; pfam13683 745776008934 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 745776008935 Transposase; Region: HTH_Tnp_1; cl17663 745776008936 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 745776008937 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745776008938 dimer interface [polypeptide binding]; other site 745776008939 phosphorylation site [posttranslational modification] 745776008940 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776008941 ATP binding site [chemical binding]; other site 745776008942 Mg2+ binding site [ion binding]; other site 745776008943 G-X-G motif; other site 745776008944 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 745776008945 H+ Antiporter protein; Region: 2A0121; TIGR00900 745776008946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745776008947 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 745776008948 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 745776008949 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 745776008950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745776008951 S-adenosylmethionine binding site [chemical binding]; other site 745776008952 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 745776008953 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 745776008954 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 745776008955 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776008956 Walker A/P-loop; other site 745776008957 ATP binding site [chemical binding]; other site 745776008958 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 745776008959 active site 745776008960 metal binding site [ion binding]; metal-binding site 745776008961 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 745776008962 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 745776008963 Transposase; Region: HTH_Tnp_1; pfam01527 745776008964 HTH-like domain; Region: HTH_21; pfam13276 745776008965 Integrase core domain; Region: rve; pfam00665 745776008966 Integrase core domain; Region: rve_3; pfam13683 745776008967 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 745776008968 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 745776008969 P-loop; other site 745776008970 Magnesium ion binding site [ion binding]; other site 745776008971 HNH endonuclease; Region: HNH_3; pfam13392 745776008972 Replication initiator protein A; Region: RPA; cl17860 745776008973 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 745776008974 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 745776008975 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 745776008976 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 745776008977 Proteasome stabiliser; Region: Ecm29; pfam13001 745776008978 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 745776008979 Family description; Region: UvrD_C_2; pfam13538 745776008980 Replication initiator protein A; Region: RPA; cl17860 745776008981 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 745776008982 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 745776008983 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 745776008984 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 745776008985 ligand binding site [chemical binding]; other site 745776008986 active site 745776008987 UGI interface [polypeptide binding]; other site 745776008988 catalytic site [active] 745776008989 Predicted transcriptional regulators [Transcription]; Region: COG1695 745776008990 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 745776008991 Bacterial SH3 domain; Region: SH3_3; pfam08239 745776008992 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 745776008993 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745776008994 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 745776008995 Coenzyme A binding pocket [chemical binding]; other site 745776008996 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 745776008997 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 745776008998 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 745776008999 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 745776009000 Walker A motif; other site 745776009001 ATP binding site [chemical binding]; other site 745776009002 Walker B motif; other site 745776009003 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 745776009004 active site 745776009005 metal binding site [ion binding]; metal-binding site 745776009006 interdomain interaction site; other site 745776009007 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 745776009008 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 745776009009 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 745776009010 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 745776009011 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 745776009012 Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162 745776009013 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 745776009014 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 745776009015 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 745776009016 P-loop; other site 745776009017 Magnesium ion binding site [ion binding]; other site 745776009018 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 745776009019 Magnesium ion binding site [ion binding]; other site 745776009020 ParB-like nuclease domain; Region: ParBc; pfam02195 745776009021 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 745776009022 metal ion-dependent adhesion site (MIDAS); other site 745776009023 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 745776009024 Methyltransferase domain; Region: Methyltransf_26; pfam13659 745776009025 helicase superfamily c-terminal domain; Region: HELICc; smart00490 745776009026 ATP-binding site [chemical binding]; other site 745776009027 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK04663 745776009028 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 745776009029 catalytic residue [active] 745776009030 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 745776009031 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 745776009032 Peptidase family M23; Region: Peptidase_M23; pfam01551 745776009033 MOC1-like protein; Provisional; Region: PLN03196 745776009034 Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123 745776009035 Protein of unknown function (DUF935); Region: DUF935; pfam06074 745776009036 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 745776009037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 745776009038 Terminase-like family; Region: Terminase_6; pfam03237 745776009039 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 745776009040 VRR-NUC domain; Region: VRR_NUC; pfam08774 745776009041 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 745776009042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 745776009043 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 745776009044 DEAD-like helicases superfamily; Region: DEXDc; smart00487 745776009045 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 745776009046 ATP binding site [chemical binding]; other site 745776009047 putative Mg++ binding site [ion binding]; other site 745776009048 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 745776009049 nucleotide binding region [chemical binding]; other site 745776009050 ATP-binding site [chemical binding]; other site 745776009051 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 745776009052 DNA methylase; Region: N6_N4_Mtase; cl17433 745776009053 methionyl-tRNA synthetase; Region: metG; TIGR00398 745776009054 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745776009055 non-specific DNA binding site [nucleotide binding]; other site 745776009056 salt bridge; other site 745776009057 sequence-specific DNA binding site [nucleotide binding]; other site 745776009058 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 745776009059 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745776009060 non-specific DNA binding site [nucleotide binding]; other site 745776009061 salt bridge; other site 745776009062 sequence-specific DNA binding site [nucleotide binding]; other site 745776009063 Methyltransferase domain; Region: Methyltransf_26; pfam13659 745776009064 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 745776009065 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 745776009066 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776009067 ATP binding site [chemical binding]; other site 745776009068 Mg2+ binding site [ion binding]; other site 745776009069 G-X-G motif; other site 745776009070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 745776009071 active site 745776009072 phosphorylation site [posttranslational modification] 745776009073 intermolecular recognition site; other site 745776009074 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 745776009075 active site 745776009076 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745776009077 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 745776009078 Coenzyme A binding pocket [chemical binding]; other site 745776009079 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 745776009080 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 745776009081 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 745776009082 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 745776009083 catalytic residues [active] 745776009084 catalytic nucleophile [active] 745776009085 Presynaptic Site I dimer interface [polypeptide binding]; other site 745776009086 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 745776009087 Synaptic Flat tetramer interface [polypeptide binding]; other site 745776009088 Synaptic Site I dimer interface [polypeptide binding]; other site 745776009089 DNA binding site [nucleotide binding] 745776009090 Recombinase; Region: Recombinase; pfam07508 745776009091 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 745776009092 DNA polymerase III subunit beta; Provisional; Region: PRK14945 745776009093 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 745776009094 putative DNA binding surface [nucleotide binding]; other site 745776009095 dimer interface [polypeptide binding]; other site 745776009096 beta-clamp/clamp loader binding surface; other site 745776009097 beta-clamp/translesion DNA polymerase binding surface; other site 745776009098 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 745776009099 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 745776009100 ATP binding site [chemical binding]; other site 745776009101 putative Mg++ binding site [ion binding]; other site 745776009102 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 745776009103 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745776009104 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 745776009105 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 745776009106 Cytochrome P450; Region: p450; pfam00067 745776009107 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 745776009108 Flavodoxin; Region: Flavodoxin_1; pfam00258 745776009109 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 745776009110 FAD binding pocket [chemical binding]; other site 745776009111 FAD binding motif [chemical binding]; other site 745776009112 catalytic residues [active] 745776009113 NAD binding pocket [chemical binding]; other site 745776009114 phosphate binding motif [ion binding]; other site 745776009115 beta-alpha-beta structure motif; other site 745776009116 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 745776009117 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 745776009118 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 745776009119 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 745776009120 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 745776009121 Integrase core domain; Region: rve; pfam00665 745776009122 Integrase core domain; Region: rve_3; pfam13683 745776009123 HTH-like domain; Region: HTH_21; pfam13276 745776009124 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 745776009125 active site 745776009126 Int/Topo IB signature motif; other site 745776009127 DNA binding site [nucleotide binding] 745776009128 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 745776009129 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 745776009130 Replication initiator protein A; Region: RPA; cl17860 745776009131 HNH endonuclease; Region: HNH_3; pfam13392 745776009132 hypothetical protein; Region: PHA01623 745776009133 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 745776009134 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 745776009135 P-loop; other site 745776009136 Magnesium ion binding site [ion binding]; other site 745776009137 Annotation is too short ref|YP_006262898| 745776009138 DDE superfamily endonuclease; Region: DDE_3; pfam13358 745776009139 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 745776009140 mismatch recognition site; other site 745776009141 additional DNA contacts [nucleotide binding]; other site 745776009142 active site 745776009143 zinc binding site [ion binding]; other site 745776009144 DNA intercalation site [nucleotide binding]; other site 745776009145 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 745776009146 Protein of unknown function (DUF524); Region: DUF524; pfam04411 745776009147 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 745776009148 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 745776009149 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 745776009150 cofactor binding site; other site 745776009151 DNA binding site [nucleotide binding] 745776009152 substrate interaction site [chemical binding]; other site 745776009153 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 745776009154 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 745776009155 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 745776009156 Nuclease-related domain; Region: NERD; pfam08378 745776009157 AAA domain; Region: AAA_22; pfam13401 745776009158 Family description; Region: UvrD_C_2; pfam13538 745776009159 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 745776009160 nucleotide binding region [chemical binding]; other site 745776009161 ATP-binding site [chemical binding]; other site 745776009162 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 745776009163 Part of AAA domain; Region: AAA_19; pfam13245 745776009164 Family description; Region: UvrD_C_2; pfam13538 745776009165 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 745776009166 Family description; Region: UvrD_C_2; pfam13538 745776009167 Predicted transcriptional regulators [Transcription]; Region: COG1695 745776009168 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 745776009169 Recombinase; Region: Recombinase; pfam07508 745776009170 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 745776009171 Catalytic domain of Protein Kinases; Region: PKc; cd00180 745776009172 active site 745776009173 ATP binding site [chemical binding]; other site 745776009174 substrate binding site [chemical binding]; other site 745776009175 activation loop (A-loop); other site 745776009176 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 745776009177 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 745776009178 active site 745776009179 zinc binding site [ion binding]; other site 745776009180 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 745776009181 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 745776009182 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776009183 Walker A/P-loop; other site 745776009184 ATP binding site [chemical binding]; other site 745776009185 Q-loop/lid; other site 745776009186 ABC transporter signature motif; other site 745776009187 Walker B; other site 745776009188 D-loop; other site 745776009189 H-loop/switch region; other site 745776009190 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 745776009191 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 745776009192 oligomeric interface; other site 745776009193 putative active site [active] 745776009194 homodimer interface [polypeptide binding]; other site 745776009195 SeqA protein; Region: SeqA; cl11470 745776009196 Predicted transcriptional regulators [Transcription]; Region: COG1695 745776009197 Transcriptional regulator PadR-like family; Region: PadR; cl17335 745776009198 Protein of unknown function DUF262; Region: DUF262; pfam03235 745776009199 Uncharacterized conserved protein [Function unknown]; Region: COG1479 745776009200 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 745776009201 Uncharacterized conserved protein [Function unknown]; Region: COG3586 745776009202 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 745776009203 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 745776009204 Family description; Region: VCBS; pfam13517 745776009205 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 745776009206 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 745776009207 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 745776009208 protein-splicing catalytic site; other site 745776009209 thioester formation/cholesterol transfer; other site 745776009210 Pretoxin HINT domain; Region: PT-HINT; pfam07591 745776009211 HEAT repeats; Region: HEAT_2; pfam13646 745776009212 DDE superfamily endonuclease; Region: DDE_3; pfam13358 745776009213 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 745776009214 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 745776009215 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745776009216 non-specific DNA binding site [nucleotide binding]; other site 745776009217 salt bridge; other site 745776009218 sequence-specific DNA binding site [nucleotide binding]; other site 745776009219 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 745776009220 Catalytic site [active] 745776009221 aspartate racemase; Region: asp_race; TIGR00035 745776009222 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 745776009223 replicative DNA helicase; Region: DnaB; TIGR00665 745776009224 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 745776009225 Walker A motif; other site 745776009226 ATP binding site [chemical binding]; other site 745776009227 Walker B motif; other site 745776009228 DNA binding loops [nucleotide binding] 745776009229 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 745776009230 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 745776009231 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 745776009232 protein-splicing catalytic site; other site 745776009233 thioester formation/cholesterol transfer; other site 745776009234 Pretoxin HINT domain; Region: PT-HINT; pfam07591 745776009235 The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424 745776009236 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 745776009237 active site 745776009238 catalytic residues [active] 745776009239 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 745776009240 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 745776009241 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 745776009242 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 745776009243 active site 745776009244 DNA binding site [nucleotide binding] 745776009245 Int/Topo IB signature motif; other site 745776009246 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 745776009247 Low molecular weight phosphatase family; Region: LMWPc; cl00105 745776009248 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 745776009249 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 745776009250 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 745776009251 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 745776009252 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 745776009253 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 745776009254 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 745776009255 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 745776009256 homodimer interface [polypeptide binding]; other site 745776009257 Walker A motif; other site 745776009258 ATP binding site [chemical binding]; other site 745776009259 hydroxycobalamin binding site [chemical binding]; other site 745776009260 Walker B motif; other site 745776009261 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 745776009262 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 745776009263 putative binding site residues; other site 745776009264 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 745776009265 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 745776009266 putative Mg++ binding site [ion binding]; other site 745776009267 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 745776009268 nucleotide binding region [chemical binding]; other site 745776009269 ATP-binding site [chemical binding]; other site 745776009270 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 745776009271 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 745776009272 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 745776009273 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 745776009274 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745776009275 NAD(P) binding site [chemical binding]; other site 745776009276 active site 745776009277 Protein kinase domain; Region: Pkinase; pfam00069 745776009278 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 745776009279 substrate binding site [chemical binding]; other site 745776009280 activation loop (A-loop); other site 745776009281 Response regulator receiver domain; Region: Response_reg; pfam00072 745776009282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776009283 active site 745776009284 phosphorylation site [posttranslational modification] 745776009285 intermolecular recognition site; other site 745776009286 dimerization interface [polypeptide binding]; other site 745776009287 CheW-like domain; Region: CheW; pfam01584 745776009288 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 745776009289 dimerization interface [polypeptide binding]; other site 745776009290 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 745776009291 putative CheW interface [polypeptide binding]; other site 745776009292 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 745776009293 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 745776009294 dimer interface [polypeptide binding]; other site 745776009295 putative CheW interface [polypeptide binding]; other site 745776009296 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 745776009297 putative binding surface; other site 745776009298 active site 745776009299 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 745776009300 putative binding surface; other site 745776009301 active site 745776009302 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 745776009303 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776009304 ATP binding site [chemical binding]; other site 745776009305 Mg2+ binding site [ion binding]; other site 745776009306 G-X-G motif; other site 745776009307 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 745776009308 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 745776009309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776009310 active site 745776009311 phosphorylation site [posttranslational modification] 745776009312 intermolecular recognition site; other site 745776009313 dimerization interface [polypeptide binding]; other site 745776009314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 745776009315 phosphorylation site [posttranslational modification] 745776009316 intermolecular recognition site; other site 745776009317 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 745776009318 Response regulator receiver domain; Region: Response_reg; pfam00072 745776009319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776009320 active site 745776009321 phosphorylation site [posttranslational modification] 745776009322 intermolecular recognition site; other site 745776009323 dimerization interface [polypeptide binding]; other site 745776009324 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 745776009325 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 745776009326 GAF domain; Region: GAF; pfam01590 745776009327 GAF domain; Region: GAF_3; pfam13492 745776009328 GAF domain; Region: GAF_2; pfam13185 745776009329 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 745776009330 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745776009331 metal binding site [ion binding]; metal-binding site 745776009332 active site 745776009333 I-site; other site 745776009334 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 745776009335 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 745776009336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745776009337 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 745776009338 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 745776009339 Walker A/P-loop; other site 745776009340 ATP binding site [chemical binding]; other site 745776009341 Q-loop/lid; other site 745776009342 ABC transporter signature motif; other site 745776009343 Walker B; other site 745776009344 D-loop; other site 745776009345 H-loop/switch region; other site 745776009346 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 745776009347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776009348 dimer interface [polypeptide binding]; other site 745776009349 conserved gate region; other site 745776009350 putative PBP binding loops; other site 745776009351 ABC-ATPase subunit interface; other site 745776009352 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 745776009353 NMT1-like family; Region: NMT1_2; pfam13379 745776009354 cyanate hydratase; Validated; Region: PRK02866 745776009355 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 745776009356 oligomer interface [polypeptide binding]; other site 745776009357 active site 745776009358 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 745776009359 molybdopterin cofactor binding site; other site 745776009360 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 745776009361 molybdopterin cofactor binding site; other site 745776009362 nitrite reductase subunit NirD; Provisional; Region: PRK14989 745776009363 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 745776009364 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 745776009365 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 745776009366 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 745776009367 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 745776009368 active site 745776009369 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 745776009370 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745776009371 metal binding site [ion binding]; metal-binding site 745776009372 active site 745776009373 I-site; other site 745776009374 FtsX-like permease family; Region: FtsX; pfam02687 745776009375 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 745776009376 AAA domain; Region: AAA_21; pfam13304 745776009377 Walker A/P-loop; other site 745776009378 ATP binding site [chemical binding]; other site 745776009379 ABC transporter; Region: ABC_tran; pfam00005 745776009380 Q-loop/lid; other site 745776009381 ABC transporter signature motif; other site 745776009382 Walker B; other site 745776009383 D-loop; other site 745776009384 H-loop/switch region; other site 745776009385 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 745776009386 HlyD family secretion protein; Region: HlyD_3; pfam13437 745776009387 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 745776009388 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 745776009389 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 745776009390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776009391 active site 745776009392 phosphorylation site [posttranslational modification] 745776009393 intermolecular recognition site; other site 745776009394 dimerization interface [polypeptide binding]; other site 745776009395 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 745776009396 DNA binding site [nucleotide binding] 745776009397 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 745776009398 dimerization interface [polypeptide binding]; other site 745776009399 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745776009400 dimer interface [polypeptide binding]; other site 745776009401 phosphorylation site [posttranslational modification] 745776009402 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776009403 ATP binding site [chemical binding]; other site 745776009404 Mg2+ binding site [ion binding]; other site 745776009405 G-X-G motif; other site 745776009406 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 745776009407 DNA-binding site [nucleotide binding]; DNA binding site 745776009408 RNA-binding motif; other site 745776009409 Domain of unkown function (DUF1775); Region: DUF1775; pfam07987 745776009410 CopC domain; Region: CopC; cl01012 745776009411 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 745776009412 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 745776009413 active site 745776009414 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 745776009415 Protein of unknown function, DUF481; Region: DUF481; cl01213 745776009416 conserved repeat domain; Region: B_ant_repeat; TIGR01451 745776009417 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 745776009418 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745776009419 metal binding site [ion binding]; metal-binding site 745776009420 active site 745776009421 I-site; other site 745776009422 Predicted esterase [General function prediction only]; Region: COG0400 745776009423 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 745776009424 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 745776009425 Zn binding site [ion binding]; other site 745776009426 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 745776009427 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 745776009428 Zn binding site [ion binding]; other site 745776009429 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 745776009430 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 745776009431 Zn binding site [ion binding]; other site 745776009432 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 745776009433 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 745776009434 Zn binding site [ion binding]; other site 745776009435 MarR family; Region: MarR; pfam01047 745776009436 Protein of unknown function DUF99; Region: DUF99; cl00704 745776009437 hypothetical protein; Provisional; Region: PRK00766 745776009438 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745776009439 Coenzyme A binding pocket [chemical binding]; other site 745776009440 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 745776009441 Coenzyme A binding pocket [chemical binding]; other site 745776009442 Stress-induced bacterial acidophilic repeat motif; Region: KGG; pfam10685 745776009443 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 745776009444 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 745776009445 active site 745776009446 metal binding site [ion binding]; metal-binding site 745776009447 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 745776009448 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 745776009449 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776009450 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 745776009451 Walker A/P-loop; other site 745776009452 ATP binding site [chemical binding]; other site 745776009453 Q-loop/lid; other site 745776009454 ABC transporter signature motif; other site 745776009455 Walker B; other site 745776009456 D-loop; other site 745776009457 H-loop/switch region; other site 745776009458 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 745776009459 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 745776009460 putative active site [active] 745776009461 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 745776009462 Annotation is too short ref|YP_006271483| 745776009463 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 745776009464 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 745776009465 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 745776009466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776009467 dimer interface [polypeptide binding]; other site 745776009468 conserved gate region; other site 745776009469 putative PBP binding loops; other site 745776009470 ABC-ATPase subunit interface; other site 745776009471 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 745776009472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776009473 dimer interface [polypeptide binding]; other site 745776009474 conserved gate region; other site 745776009475 putative PBP binding loops; other site 745776009476 ABC-ATPase subunit interface; other site 745776009477 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 745776009478 TPR motif; other site 745776009479 binding surface 745776009480 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 745776009481 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 745776009482 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 745776009483 siderophore binding site; other site 745776009484 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 745776009485 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 745776009486 intersubunit interface [polypeptide binding]; other site 745776009487 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 745776009488 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 745776009489 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 745776009490 ABC-ATPase subunit interface; other site 745776009491 dimer interface [polypeptide binding]; other site 745776009492 putative PBP binding regions; other site 745776009493 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 745776009494 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 745776009495 siderophore binding site; other site 745776009496 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 745776009497 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 745776009498 putative PBP binding regions; other site 745776009499 ABC-ATPase subunit interface; other site 745776009500 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 745776009501 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 745776009502 Walker A/P-loop; other site 745776009503 ATP binding site [chemical binding]; other site 745776009504 Q-loop/lid; other site 745776009505 ABC transporter signature motif; other site 745776009506 Walker B; other site 745776009507 D-loop; other site 745776009508 H-loop/switch region; other site 745776009509 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 745776009510 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 745776009511 active site 745776009512 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 745776009513 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 745776009514 E-class dimer interface [polypeptide binding]; other site 745776009515 P-class dimer interface [polypeptide binding]; other site 745776009516 active site 745776009517 Cu2+ binding site [ion binding]; other site 745776009518 Zn2+ binding site [ion binding]; other site 745776009519 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 745776009520 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 745776009521 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 745776009522 Iron permease FTR1 family; Region: FTR1; cl00475 745776009523 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 745776009524 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 745776009525 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 745776009526 Walker A/P-loop; other site 745776009527 ATP binding site [chemical binding]; other site 745776009528 Q-loop/lid; other site 745776009529 ABC transporter signature motif; other site 745776009530 Walker B; other site 745776009531 D-loop; other site 745776009532 H-loop/switch region; other site 745776009533 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 745776009534 putative active site [active] 745776009535 Amino acid permease; Region: AA_permease_2; pfam13520 745776009536 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 745776009537 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 745776009538 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 745776009539 D-pathway; other site 745776009540 Putative ubiquinol binding site [chemical binding]; other site 745776009541 Low-spin heme (heme b) binding site [chemical binding]; other site 745776009542 Putative water exit pathway; other site 745776009543 Binuclear center (heme o3/CuB) [ion binding]; other site 745776009544 K-pathway; other site 745776009545 Putative proton exit pathway; other site 745776009546 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 745776009547 Subunit I/III interface [polypeptide binding]; other site 745776009548 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 745776009549 iron-sulfur cluster [ion binding]; other site 745776009550 [2Fe-2S] cluster binding site [ion binding]; other site 745776009551 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 745776009552 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 745776009553 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 745776009554 heme bH binding site [chemical binding]; other site 745776009555 intrachain domain interface; other site 745776009556 Qi binding site; other site 745776009557 heme bL binding site [chemical binding]; other site 745776009558 interchain domain interface [polypeptide binding]; other site 745776009559 Qo binding site; other site 745776009560 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 745776009561 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 745776009562 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 745776009563 PAS domain; Region: PAS_9; pfam13426 745776009564 putative active site [active] 745776009565 heme pocket [chemical binding]; other site 745776009566 PAS domain S-box; Region: sensory_box; TIGR00229 745776009567 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 745776009568 putative active site [active] 745776009569 heme pocket [chemical binding]; other site 745776009570 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 745776009571 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745776009572 metal binding site [ion binding]; metal-binding site 745776009573 active site 745776009574 I-site; other site 745776009575 Domain of unknown function (DUF305); Region: DUF305; pfam03713 745776009576 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 745776009577 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 745776009578 sugar binding site [chemical binding]; other site 745776009579 PAS fold; Region: PAS_4; pfam08448 745776009580 GAF domain; Region: GAF_2; pfam13185 745776009581 GAF domain; Region: GAF_3; pfam13492 745776009582 GAF domain; Region: GAF_3; pfam13492 745776009583 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745776009584 dimer interface [polypeptide binding]; other site 745776009585 phosphorylation site [posttranslational modification] 745776009586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776009587 ATP binding site [chemical binding]; other site 745776009588 Mg2+ binding site [ion binding]; other site 745776009589 G-X-G motif; other site 745776009590 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 745776009591 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 745776009592 DDE superfamily endonuclease; Region: DDE_3; pfam13358 745776009593 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 745776009594 Annotation is too short ref|YP_006271528| 745776009595 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 745776009596 Beta-lactamase; Region: Beta-lactamase; pfam00144 745776009597 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 745776009598 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 745776009599 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 745776009600 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 745776009601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776009602 conserved gate region; other site 745776009603 ABC-ATPase subunit interface; other site 745776009604 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 745776009605 active site 745776009606 Int/Topo IB signature motif; other site 745776009607 DNA binding site [nucleotide binding] 745776009608 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 745776009609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745776009610 active site 745776009611 phosphorylation site [posttranslational modification] 745776009612 intermolecular recognition site; other site 745776009613 dimerization interface [polypeptide binding]; other site 745776009614 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 745776009615 DNA binding residues [nucleotide binding] 745776009616 dimerization interface [polypeptide binding]; other site 745776009617 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 745776009618 Histidine kinase; Region: HisKA_3; pfam07730 745776009619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776009620 ATP binding site [chemical binding]; other site 745776009621 Mg2+ binding site [ion binding]; other site 745776009622 G-X-G motif; other site 745776009623 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 745776009624 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 745776009625 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 745776009626 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 745776009627 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 745776009628 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 745776009629 nucleotide binding site [chemical binding]; other site 745776009630 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 745776009631 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 745776009632 FRG domain; Region: FRG; pfam08867 745776009633 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 745776009634 dimanganese center [ion binding]; other site 745776009635 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745776009636 metal binding site [ion binding]; metal-binding site 745776009637 active site 745776009638 I-site; other site 745776009639 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 745776009640 potential frameshift: common BLAST hit: gi|226355096|ref|YP_002784836.1| PAS:CheB methylesterase:MCP methyltransferase 745776009641 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 745776009642 PAS fold; Region: PAS; pfam00989 745776009643 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 745776009644 PAS domain; Region: PAS_10; pfam13596 745776009645 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 745776009646 PAS fold; Region: PAS; pfam00989 745776009647 putative active site [active] 745776009648 heme pocket [chemical binding]; other site 745776009649 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 745776009650 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 745776009651 spore photoproduct lyase family protein; Region: lyase_spl_fam; TIGR03886 745776009652 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 745776009653 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 745776009654 ATP binding site [chemical binding]; other site 745776009655 putative Mg++ binding site [ion binding]; other site 745776009656 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 745776009657 nucleotide binding region [chemical binding]; other site 745776009658 ATP-binding site [chemical binding]; other site 745776009659 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 745776009660 Protein of unknown function (DUF790); Region: DUF790; pfam05626 745776009661 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 745776009662 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 745776009663 active site 745776009664 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 745776009665 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 745776009666 Prephenate dehydratase; Region: PDT; pfam00800 745776009667 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 745776009668 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 745776009669 Chromate transporter; Region: Chromate_transp; pfam02417 745776009670 Penicillin amidase; Region: Penicil_amidase; pfam01804 745776009671 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 745776009672 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 745776009673 active site 745776009674 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 745776009675 Transcriptional regulators [Transcription]; Region: PurR; COG1609 745776009676 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745776009677 DNA binding site [nucleotide binding] 745776009678 domain linker motif; other site 745776009679 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 745776009680 dimerization interface [polypeptide binding]; other site 745776009681 ligand binding site [chemical binding]; other site 745776009682 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 745776009683 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 745776009684 dimer interface [polypeptide binding]; other site 745776009685 substrate binding site [chemical binding]; other site 745776009686 ATP binding site [chemical binding]; other site 745776009687 D-ribose pyranase; Provisional; Region: PRK11797 745776009688 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 745776009689 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 745776009690 Walker A/P-loop; other site 745776009691 ATP binding site [chemical binding]; other site 745776009692 Q-loop/lid; other site 745776009693 ABC transporter signature motif; other site 745776009694 Walker B; other site 745776009695 D-loop; other site 745776009696 H-loop/switch region; other site 745776009697 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 745776009698 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 745776009699 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 745776009700 TM-ABC transporter signature motif; other site 745776009701 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 745776009702 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 745776009703 ligand binding site [chemical binding]; other site 745776009704 dimerization interface [polypeptide binding]; other site 745776009705 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 745776009706 sugar binding site [chemical binding]; other site 745776009707 Transcriptional regulators [Transcription]; Region: PurR; COG1609 745776009708 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745776009709 DNA binding site [nucleotide binding] 745776009710 domain linker motif; other site 745776009711 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 745776009712 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 745776009713 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 745776009714 active site 745776009715 dimer interface [polypeptide binding]; other site 745776009716 non-prolyl cis peptide bond; other site 745776009717 insertion regions; other site 745776009718 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 745776009719 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745776009720 substrate binding pocket [chemical binding]; other site 745776009721 membrane-bound complex binding site; other site 745776009722 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 745776009723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776009724 dimer interface [polypeptide binding]; other site 745776009725 conserved gate region; other site 745776009726 putative PBP binding loops; other site 745776009727 ABC-ATPase subunit interface; other site 745776009728 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 745776009729 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776009730 Walker A/P-loop; other site 745776009731 ATP binding site [chemical binding]; other site 745776009732 Q-loop/lid; other site 745776009733 ABC transporter signature motif; other site 745776009734 Walker B; other site 745776009735 D-loop; other site 745776009736 H-loop/switch region; other site 745776009737 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 745776009738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745776009739 putative substrate translocation pore; other site 745776009740 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 745776009741 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 745776009742 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 745776009743 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 745776009744 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 745776009745 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 745776009746 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 745776009747 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 745776009748 active site 745776009749 catalytic residues [active] 745776009750 Tetratricopeptide repeat; Region: TPR_12; pfam13424 745776009751 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 745776009752 binding surface 745776009753 TPR motif; other site 745776009754 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 745776009755 Zn2+ binding site [ion binding]; other site 745776009756 Mg2+ binding site [ion binding]; other site 745776009757 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 745776009758 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 745776009759 active site 745776009760 Zn binding site [ion binding]; other site 745776009761 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 745776009762 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 745776009763 UDP-galactopyranose mutase; Region: GLF; pfam03275 745776009764 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 745776009765 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 745776009766 putative homodimer interface [polypeptide binding]; other site 745776009767 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 745776009768 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745776009769 S-adenosylmethionine binding site [chemical binding]; other site 745776009770 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 745776009771 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 745776009772 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 745776009773 active site 745776009774 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 745776009775 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 745776009776 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 745776009777 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 745776009778 FeS/SAM binding site; other site 745776009779 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 745776009780 Cytochrome P450; Region: p450; cl12078 745776009781 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 745776009782 iron-sulfur cluster [ion binding]; other site 745776009783 [2Fe-2S] cluster binding site [ion binding]; other site 745776009784 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 745776009785 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 745776009786 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 745776009787 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 745776009788 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 745776009789 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 745776009790 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 745776009791 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 745776009792 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776009793 Walker A/P-loop; other site 745776009794 ATP binding site [chemical binding]; other site 745776009795 ABC transporter; Region: ABC_tran; pfam00005 745776009796 Q-loop/lid; other site 745776009797 ABC transporter signature motif; other site 745776009798 Walker B; other site 745776009799 D-loop; other site 745776009800 H-loop/switch region; other site 745776009801 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 745776009802 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 745776009803 Walker A/P-loop; other site 745776009804 ATP binding site [chemical binding]; other site 745776009805 Q-loop/lid; other site 745776009806 ABC transporter signature motif; other site 745776009807 Walker B; other site 745776009808 D-loop; other site 745776009809 H-loop/switch region; other site 745776009810 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 745776009811 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 745776009812 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 745776009813 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 745776009814 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776009815 Walker B; other site 745776009816 D-loop; other site 745776009817 H-loop/switch region; other site 745776009818 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776009819 Q-loop/lid; other site 745776009820 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 745776009821 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 745776009822 TM-ABC transporter signature motif; other site 745776009823 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 745776009824 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 745776009825 Walker A/P-loop; other site 745776009826 ATP binding site [chemical binding]; other site 745776009827 Q-loop/lid; other site 745776009828 ABC transporter signature motif; other site 745776009829 Walker B; other site 745776009830 D-loop; other site 745776009831 H-loop/switch region; other site 745776009832 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 745776009833 TM-ABC transporter signature motif; other site 745776009834 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 745776009835 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 745776009836 putative ligand binding site [chemical binding]; other site 745776009837 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 745776009838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776009839 ABC-ATPase subunit interface; other site 745776009840 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776009841 ABC transporter; Region: ABC_tran; pfam00005 745776009842 Q-loop/lid; other site 745776009843 ABC transporter signature motif; other site 745776009844 Walker B; other site 745776009845 D-loop; other site 745776009846 H-loop/switch region; other site 745776009847 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 745776009848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776009849 dimer interface [polypeptide binding]; other site 745776009850 conserved gate region; other site 745776009851 ABC-ATPase subunit interface; other site 745776009852 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 745776009853 ribonucleoside-diphosphate reductase, class 1b, alpha subunit; Region: RNR_1b_NrdE; TIGR04170 745776009854 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 745776009855 Class I ribonucleotide reductase; Region: RNR_I; cd01679 745776009856 active site 745776009857 dimer interface [polypeptide binding]; other site 745776009858 catalytic residues [active] 745776009859 effector binding site; other site 745776009860 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 745776009861 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 745776009862 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 745776009863 dimer interface [polypeptide binding]; other site 745776009864 putative radical transfer pathway; other site 745776009865 diiron center [ion binding]; other site 745776009866 tyrosyl radical; other site 745776009867 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 745776009868 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 745776009869 NAD binding site [chemical binding]; other site 745776009870 catalytic Zn binding site [ion binding]; other site 745776009871 structural Zn binding site [ion binding]; other site 745776009872 Predicted integral membrane protein [Function unknown]; Region: COG5637 745776009873 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 745776009874 putative hydrophobic ligand binding site [chemical binding]; other site 745776009875 META domain; Region: META; pfam03724 745776009876 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 745776009877 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 745776009878 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 745776009879 Domain of unknown function DUF20; Region: UPF0118; pfam01594 745776009880 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 745776009881 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 745776009882 acyl-activating enzyme (AAE) consensus motif; other site 745776009883 AMP binding site [chemical binding]; other site 745776009884 active site 745776009885 CoA binding site [chemical binding]; other site 745776009886 PAS domain; Region: PAS; smart00091 745776009887 PAS domain; Region: PAS_9; pfam13426 745776009888 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 745776009889 GAF domain; Region: GAF; cl17456 745776009890 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745776009891 dimer interface [polypeptide binding]; other site 745776009892 phosphorylation site [posttranslational modification] 745776009893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745776009894 ATP binding site [chemical binding]; other site 745776009895 G-X-G motif; other site 745776009896 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 745776009897 conserved cys residue [active] 745776009898 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 745776009899 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 745776009900 urate oxidase; Region: urate_oxi; TIGR03383 745776009901 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 745776009902 active site 745776009903 Uncharacterized conserved protein [Function unknown]; Region: COG0327 745776009904 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 745776009905 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745776009906 metal binding site [ion binding]; metal-binding site 745776009907 active site 745776009908 I-site; other site 745776009909 PAS fold; Region: PAS_4; pfam08448 745776009910 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 745776009911 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745776009912 metal binding site [ion binding]; metal-binding site 745776009913 active site 745776009914 I-site; other site 745776009915 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 745776009916 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 745776009917 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745776009918 metal binding site [ion binding]; metal-binding site 745776009919 active site 745776009920 I-site; other site 745776009921 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745776009922 non-specific DNA binding site [nucleotide binding]; other site 745776009923 salt bridge; other site 745776009924 sequence-specific DNA binding site [nucleotide binding]; other site 745776009925 Cupin domain; Region: Cupin_2; pfam07883 745776009926 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 745776009927 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 745776009928 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 745776009929 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 745776009930 acyl-activating enzyme (AAE) consensus motif; other site 745776009931 AMP binding site [chemical binding]; other site 745776009932 active site 745776009933 CoA binding site [chemical binding]; other site 745776009934 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 745776009935 malate synthase A; Region: malate_syn_A; TIGR01344 745776009936 active site 745776009937 Bacterial transcriptional regulator; Region: IclR; pfam01614 745776009938 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; cl02325 745776009939 Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl17217 745776009940 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 745776009941 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 745776009942 active site 745776009943 metal binding site [ion binding]; metal-binding site 745776009944 dimer interface [polypeptide binding]; other site 745776009945 allantoinase; Provisional; Region: PRK06189 745776009946 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 745776009947 active site 745776009948 putative allantoin catabolism protein; Region: ura-cupin; TIGR03214 745776009949 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 745776009950 Cupin domain; Region: Cupin_2; cl17218 745776009951 AzlC protein; Region: AzlC; pfam03591 745776009952 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 745776009953 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 745776009954 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 745776009955 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 745776009956 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776009957 dimer interface [polypeptide binding]; other site 745776009958 conserved gate region; other site 745776009959 putative PBP binding loops; other site 745776009960 ABC-ATPase subunit interface; other site 745776009961 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 745776009962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776009963 putative PBP binding loops; other site 745776009964 ABC-ATPase subunit interface; other site 745776009965 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 745776009966 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 745776009967 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 745776009968 dimerization interface [polypeptide binding]; other site 745776009969 ligand binding site [chemical binding]; other site 745776009970 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 745776009971 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 745776009972 active site 745776009973 substrate binding site [chemical binding]; other site 745776009974 metal binding site [ion binding]; metal-binding site 745776009975 O-Antigen ligase; Region: Wzy_C; pfam04932 745776009976 DDE superfamily endonuclease; Region: DDE_5; cl17874 745776009977 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 745776009978 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 745776009979 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 745776009980 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 745776009981 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 745776009982 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 745776009983 putative ADP-binding pocket [chemical binding]; other site 745776009984 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 745776009985 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 745776009986 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 745776009987 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 745776009988 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 745776009989 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 745776009990 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 745776009991 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 745776009992 active site 745776009993 potential frameshift: common BLAST hit: gi|320107171|ref|YP_004182761.1| polysaccharide biosynthesis protein 745776009994 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 745776009995 Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022 745776009996 CoA binding domain; Region: CoA_binding; cl17356 745776009997 Bacterial sugar transferase; Region: Bac_transf; pfam02397 745776009998 Chain length determinant protein; Region: Wzz; cl15801 745776009999 AAA domain; Region: AAA_31; pfam13614 745776010000 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 745776010001 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 745776010002 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 745776010003 Substrate binding site; other site 745776010004 Cupin domain; Region: Cupin_2; cl17218 745776010005 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 745776010006 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 745776010007 substrate binding site; other site 745776010008 metal-binding site 745776010009 Oligomer interface; other site 745776010010 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 745776010011 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 745776010012 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 745776010013 substrate-cofactor binding pocket; other site 745776010014 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745776010015 catalytic residue [active] 745776010016 aminodeoxychorismate synthase; Provisional; Region: PRK07508 745776010017 chorismate binding enzyme; Region: Chorismate_bind; cl10555 745776010018 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 745776010019 active site 745776010020 catalytic residues [active] 745776010021 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14323 745776010022 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 745776010023 active site 745776010024 substrate binding site [chemical binding]; other site 745776010025 metal binding site [ion binding]; metal-binding site 745776010026 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 745776010027 active site 745776010028 catalytic residues [active] 745776010029 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 745776010030 IHF - DNA interface [nucleotide binding]; other site 745776010031 IHF dimer interface [polypeptide binding]; other site 745776010032 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776010033 dimer interface [polypeptide binding]; other site 745776010034 conserved gate region; other site 745776010035 putative PBP binding loops; other site 745776010036 ABC-ATPase subunit interface; other site 745776010037 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 745776010038 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776010039 putative PBP binding loops; other site 745776010040 ABC-ATPase subunit interface; other site 745776010041 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745776010042 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 745776010043 substrate binding pocket [chemical binding]; other site 745776010044 membrane-bound complex binding site; other site 745776010045 hinge residues; other site 745776010046 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 745776010047 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776010048 Walker B; other site 745776010049 D-loop; other site 745776010050 H-loop/switch region; other site 745776010051 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 745776010052 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 745776010053 substrate binding [chemical binding]; other site 745776010054 active site 745776010055 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 745776010056 DinB family; Region: DinB; cl17821 745776010057 DinB superfamily; Region: DinB_2; pfam12867 745776010058 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 745776010059 classical (c) SDRs; Region: SDR_c; cd05233 745776010060 NAD(P) binding site [chemical binding]; other site 745776010061 active site 745776010062 DinB family; Region: DinB; cl17821 745776010063 DinB superfamily; Region: DinB_2; pfam12867 745776010064 Predicted transcriptional regulator [Transcription]; Region: COG2378 745776010065 HTH domain; Region: HTH_11; pfam08279 745776010066 WYL domain; Region: WYL; pfam13280 745776010067 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 745776010068 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 745776010069 NAD(P) binding site [chemical binding]; other site 745776010070 active site 745776010071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 745776010072 pyridoxamine kinase; Validated; Region: PRK05756 745776010073 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 745776010074 pyridoxal binding site [chemical binding]; other site 745776010075 dimer interface [polypeptide binding]; other site 745776010076 ATP binding site [chemical binding]; other site 745776010077 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 745776010078 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 745776010079 active site 745776010080 catalytic residues [active] 745776010081 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 745776010082 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 745776010083 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 745776010084 beta-galactosidase; Region: BGL; TIGR03356 745776010085 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 745776010086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776010087 dimer interface [polypeptide binding]; other site 745776010088 conserved gate region; other site 745776010089 putative PBP binding loops; other site 745776010090 ABC-ATPase subunit interface; other site 745776010091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776010092 dimer interface [polypeptide binding]; other site 745776010093 conserved gate region; other site 745776010094 putative PBP binding loops; other site 745776010095 ABC-ATPase subunit interface; other site 745776010096 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 745776010097 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 745776010098 Transcriptional regulators [Transcription]; Region: PurR; COG1609 745776010099 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745776010100 DNA binding site [nucleotide binding] 745776010101 domain linker motif; other site 745776010102 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_9; cd06290 745776010103 putative dimerization interface [polypeptide binding]; other site 745776010104 putative ligand binding site [chemical binding]; other site 745776010105 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 745776010106 catalytic core [active] 745776010107 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 745776010108 putative active site [active] 745776010109 ATP binding site [chemical binding]; other site 745776010110 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 745776010111 putative substrate binding site [chemical binding]; other site 745776010112 hypothetical protein; Provisional; Region: PRK06194 745776010113 classical (c) SDRs; Region: SDR_c; cd05233 745776010114 NAD(P) binding site [chemical binding]; other site 745776010115 active site 745776010116 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 745776010117 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 745776010118 FAD binding site [chemical binding]; other site 745776010119 substrate binding site [chemical binding]; other site 745776010120 catalytic base [active] 745776010121 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 745776010122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745776010123 NAD(P) binding site [chemical binding]; other site 745776010124 active site 745776010125 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 745776010126 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 745776010127 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 745776010128 putative active site [active] 745776010129 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 745776010130 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 745776010131 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 745776010132 active site 745776010133 catalytic residues [active] 745776010134 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 745776010135 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 745776010136 DNA binding residues [nucleotide binding] 745776010137 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 745776010138 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 745776010139 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 745776010140 G1 box; other site 745776010141 GTP/Mg2+ binding site [chemical binding]; other site 745776010142 G2 box; other site 745776010143 Switch I region; other site 745776010144 G3 box; other site 745776010145 Switch II region; other site 745776010146 G4 box; other site 745776010147 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 745776010148 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 745776010149 Transcriptional regulators [Transcription]; Region: PurR; COG1609 745776010150 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745776010151 DNA binding site [nucleotide binding] 745776010152 domain linker motif; other site 745776010153 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 745776010154 dimerization interface [polypeptide binding]; other site 745776010155 ligand binding site [chemical binding]; other site 745776010156 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 745776010157 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776010158 Walker A/P-loop; other site 745776010159 ATP binding site [chemical binding]; other site 745776010160 Q-loop/lid; other site 745776010161 ABC transporter signature motif; other site 745776010162 Walker B; other site 745776010163 D-loop; other site 745776010164 H-loop/switch region; other site 745776010165 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 745776010166 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 745776010167 TM-ABC transporter signature motif; other site 745776010168 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 745776010169 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 745776010170 Uncharacterized conserved protein [Function unknown]; Region: COG3538 745776010171 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 745776010172 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 745776010173 active site 745776010174 catalytic site [active] 745776010175 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 745776010176 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 745776010177 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 745776010178 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 745776010179 nucleotide binding site [chemical binding]; other site 745776010180 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 745776010181 putative active site [active] 745776010182 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 745776010183 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 745776010184 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 745776010185 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 745776010186 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745776010187 NAD(P) binding site [chemical binding]; other site 745776010188 active site 745776010189 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 745776010190 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 745776010191 metal binding site 2 [ion binding]; metal-binding site 745776010192 putative DNA binding helix; other site 745776010193 metal binding site 1 [ion binding]; metal-binding site 745776010194 dimer interface [polypeptide binding]; other site 745776010195 structural Zn2+ binding site [ion binding]; other site 745776010196 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 745776010197 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 745776010198 tetramer interface [polypeptide binding]; other site 745776010199 heme binding pocket [chemical binding]; other site 745776010200 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 745776010201 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 745776010202 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 745776010203 putative active site cavity [active] 745776010204 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 745776010205 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 745776010206 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 745776010207 Magnesium ion binding site [ion binding]; other site 745776010208 ParB-like nuclease domain; Region: ParBc; pfam02195 745776010209 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 745776010210 potential frameshift: common BLAST hit: gi|108803243|ref|YP_643180.1| xylose isomerase-like protein 745776010211 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 745776010212 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 745776010213 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 745776010214 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 745776010215 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 745776010216 Replication initiator protein A; Region: RPA; cl17860 745776010217 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630 745776010218 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 745776010219 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 745776010220 Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631 745776010221 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 745776010222 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 745776010223 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 745776010224 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 745776010225 XdhC Rossmann domain; Region: XdhC_C; pfam13478 745776010226 guanine deaminase; Provisional; Region: PRK09228 745776010227 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 745776010228 active site 745776010229 H+ Antiporter protein; Region: 2A0121; TIGR00900 745776010230 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 745776010231 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745776010232 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 745776010233 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 745776010234 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 745776010235 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 745776010236 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 745776010237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776010238 ABC-ATPase subunit interface; other site 745776010239 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 745776010240 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745776010241 Walker A/P-loop; other site 745776010242 ATP binding site [chemical binding]; other site 745776010243 Q-loop/lid; other site 745776010244 ABC transporter signature motif; other site 745776010245 Walker B; other site 745776010246 D-loop; other site 745776010247 H-loop/switch region; other site 745776010248 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745776010249 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 745776010250 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 745776010251 Coenzyme A binding pocket [chemical binding]; other site 745776010252 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 745776010253 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 745776010254 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 745776010255 Phage Tail Collar Domain; Region: Collar; pfam07484 745776010256 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 745776010257 Phage Tail Collar Domain; Region: Collar; pfam07484 745776010258 PAS fold; Region: PAS_4; pfam08448 745776010259 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 745776010260 putative active site [active] 745776010261 heme pocket [chemical binding]; other site 745776010262 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 745776010263 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745776010264 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 745776010265 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745776010266 Predicted membrane protein [Function unknown]; Region: COG1511 745776010267 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 745776010268 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 745776010269 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 745776010270 transketolase; Reviewed; Region: PRK05899 745776010271 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 745776010272 TPP-binding site [chemical binding]; other site 745776010273 dimer interface [polypeptide binding]; other site 745776010274 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 745776010275 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 745776010276 PYR/PP interface [polypeptide binding]; other site 745776010277 dimer interface [polypeptide binding]; other site 745776010278 TPP binding site [chemical binding]; other site 745776010279 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 745776010280 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 745776010281 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 745776010282 nucleotide binding site [chemical binding]; other site 745776010283 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 745776010284 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 745776010285 TM-ABC transporter signature motif; other site 745776010286 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 745776010287 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 745776010288 ligand binding site [chemical binding]; other site 745776010289 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 745776010290 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 745776010291 Walker A/P-loop; other site 745776010292 ATP binding site [chemical binding]; other site 745776010293 Q-loop/lid; other site 745776010294 ABC transporter signature motif; other site 745776010295 Walker B; other site 745776010296 D-loop; other site 745776010297 H-loop/switch region; other site 745776010298 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 745776010299 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 745776010300 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 745776010301 DNA binding residues [nucleotide binding] 745776010302 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 745776010303 short chain dehydrogenase; Provisional; Region: PRK06114 745776010304 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745776010305 NAD(P) binding site [chemical binding]; other site 745776010306 active site 745776010307 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 745776010308 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745776010309 NAD(P) binding site [chemical binding]; other site 745776010310 active site 745776010311 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 745776010312 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 745776010313 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 745776010314 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 745776010315 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745776010316 Walker A/P-loop; other site 745776010317 ATP binding site [chemical binding]; other site 745776010318 Q-loop/lid; other site 745776010319 ABC transporter signature motif; other site 745776010320 Walker B; other site 745776010321 D-loop; other site 745776010322 H-loop/switch region; other site 745776010323 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745776010324 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 745776010325 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 745776010326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776010327 putative PBP binding loops; other site 745776010328 ABC-ATPase subunit interface; other site 745776010329 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 745776010330 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745776010331 Walker A/P-loop; other site 745776010332 ATP binding site [chemical binding]; other site 745776010333 Q-loop/lid; other site 745776010334 ABC transporter signature motif; other site 745776010335 Walker B; other site 745776010336 D-loop; other site 745776010337 H-loop/switch region; other site 745776010338 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745776010339 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 745776010340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745776010341 conserved gate region; other site 745776010342 putative PBP binding loops; other site 745776010343 ABC-ATPase subunit interface; other site 745776010344 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 745776010345 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 745776010346 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 745776010347 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 745776010348 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 745776010349 ligand binding site [chemical binding]; other site 745776010350 dimerization interface [polypeptide binding]; other site 745776010351 Low affinity iron permease; Region: Iron_permease; cl12096 745776010352 FtsH Extracellular; Region: FtsH_ext; pfam06480 745776010353 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 745776010354 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745776010355 Walker A motif; other site 745776010356 ATP binding site [chemical binding]; other site 745776010357 Walker B motif; other site 745776010358 arginine finger; other site 745776010359 Peptidase family M41; Region: Peptidase_M41; pfam01434 745776010360 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 745776010361 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 745776010362 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 745776010363 active site 745776010364 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 745776010365 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 745776010366 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 745776010367 NAD(P) binding site [chemical binding]; other site 745776010368 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 745776010369 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 745776010370 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 745776010371 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 745776010372 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 745776010373 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 745776010374 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 745776010375 putative dimer interface [polypeptide binding]; other site 745776010376 active site pocket [active] 745776010377 putative cataytic base [active] 745776010378 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; pfam02283 745776010379 cobyric acid synthase; Provisional; Region: PRK00784 745776010380 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 745776010381 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 745776010382 catalytic triad [active] 745776010383 Integrase core domain; Region: rve; pfam00665 745776010384 Integrase core domain; Region: rve_3; pfam13683 745776010385 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 745776010386 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 745776010387 active site 745776010388 Int/Topo IB signature motif; other site 745776010389 DNA binding site [nucleotide binding] 745776010390 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 745776010391 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 745776010392 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 745776010393 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 745776010394 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 745776010395 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 745776010396 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cl09719 745776010397 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 745776010398 Predicted transcriptional regulator [Transcription]; Region: COG2378 745776010399 WYL domain; Region: WYL; pfam13280 745776010400 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 745776010401 binding surface 745776010402 TPR motif; other site 745776010403 Tetratricopeptide repeat; Region: TPR_12; pfam13424 745776010404 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 745776010405 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 745776010406 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 745776010407 Annotation is too short ref|YP_006271830| 745776010408 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 745776010409 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 745776010410 P-loop; other site 745776010411 Magnesium ion binding site [ion binding]; other site 745776010412 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 745776010413 Magnesium ion binding site [ion binding]; other site 745776010414 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 745776010415 ParB-like nuclease domain; Region: ParB; smart00470 745776010416 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 745776010417 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 745776010418 homodimer interface [polypeptide binding]; other site 745776010419 putative active site [active] 745776010420 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 745776010421 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 745776010422 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 745776010423 Helix-turn-helix domain; Region: HTH_36; pfam13730 745776010424 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 745776010425 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 745776010426 GIY-YIG motif/motif A; other site 745776010427 active site 745776010428 catalytic site [active] 745776010429 metal binding site [ion binding]; metal-binding site 745776010430 N-terminal catalytic domain of GIY-YIG intron endonuclease I-TevI, I-BmoI, I-BanI, I-BthII and similar proteins; Region: GIY-YIG_HE_I-TevI_like; cd10437 745776010431 GIY-YIG motif/motif A; other site 745776010432 putative active site [active] 745776010433 catalytic site [active] 745776010434 putative metal binding site [ion binding]; other site 745776010435 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745776010436 non-specific DNA binding site [nucleotide binding]; other site 745776010437 salt bridge; other site 745776010438 sequence-specific DNA binding site [nucleotide binding]; other site 745776010439 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745776010440 non-specific DNA binding site [nucleotide binding]; other site 745776010441 salt bridge; other site 745776010442 sequence-specific DNA binding site [nucleotide binding]; other site 745776010443 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 745776010444 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 745776010445 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 745776010446 AAA ATPase domain; Region: AAA_16; pfam13191 745776010447 HNH endonuclease; Region: HNH_3; pfam13392 745776010448 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 745776010449 Transposase; Region: HTH_Tnp_1; cl17663 745776010450 Integrase core domain; Region: rve; pfam00665 745776010451 Integrase core domain; Region: rve_3; pfam13683