-- dump date   	20140619_060416
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
709986000001	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
709986000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
709986000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
709986000004	Walker A motif; other site
709986000005	ATP binding site [chemical binding]; other site
709986000006	Walker B motif; other site
709986000007	arginine finger; other site
709986000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
709986000009	DnaA box-binding interface [nucleotide binding]; other site
709986000010	DNA polymerase III subunit beta; Provisional; Region: PRK14945
709986000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
709986000012	putative DNA binding surface [nucleotide binding]; other site
709986000013	dimer interface [polypeptide binding]; other site
709986000014	beta-clamp/clamp loader binding surface; other site
709986000015	beta-clamp/translesion DNA polymerase binding surface; other site
709986000016	enolase; Provisional; Region: eno; PRK00077
709986000017	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
709986000018	dimer interface [polypeptide binding]; other site
709986000019	metal binding site [ion binding]; metal-binding site
709986000020	substrate binding pocket [chemical binding]; other site
709986000021	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
709986000022	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
709986000023	domain interfaces; other site
709986000024	active site
709986000025	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
709986000026	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
709986000027	active site
709986000028	HIGH motif; other site
709986000029	dimer interface [polypeptide binding]; other site
709986000030	KMSKS motif; other site
709986000031	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
709986000032	RNA binding surface [nucleotide binding]; other site
709986000033	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
709986000034	MOSC domain; Region: MOSC; pfam03473
709986000035	Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350
709986000036	Family of unknown function (DUF633); Region: DUF633; pfam04816
709986000037	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
709986000038	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
709986000039	generic binding surface II; other site
709986000040	generic binding surface I; other site
709986000041	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
709986000042	putative active site [active]
709986000043	putative catalytic site [active]
709986000044	putative Mg binding site IVb [ion binding]; other site
709986000045	putative phosphate binding site [ion binding]; other site
709986000046	putative DNA binding site [nucleotide binding]; other site
709986000047	putative Mg binding site IVa [ion binding]; other site
709986000048	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
709986000049	active site
709986000050	homotetramer interface [polypeptide binding]; other site
709986000051	homodimer interface [polypeptide binding]; other site
709986000052	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
709986000053	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
709986000054	WHG domain; Region: WHG; pfam13305
709986000055	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
709986000056	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
709986000057	NAD(P) binding site [chemical binding]; other site
709986000058	active site
709986000059	HTH domain; Region: HTH_11; cl17392
709986000060	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
709986000061	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
709986000062	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
709986000063	BioY family; Region: BioY; pfam02632
709986000064	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
709986000065	active site
709986000066	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
709986000067	DNA polymerase III subunit delta'; Validated; Region: PRK08485
709986000068	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
709986000069	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
709986000070	active site
709986000071	metal binding site [ion binding]; metal-binding site
709986000072	Peptidase C26; Region: Peptidase_C26; pfam07722
709986000073	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
709986000074	catalytic triad [active]
709986000075	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
709986000076	HemN C-terminal domain; Region: HemN_C; pfam06969
709986000077	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
709986000078	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
709986000079	Walker A motif; other site
709986000080	ATP binding site [chemical binding]; other site
709986000081	Walker B motif; other site
709986000082	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
709986000083	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
709986000084	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
709986000085	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
709986000086	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
709986000087	Walker A motif; other site
709986000088	ATP binding site [chemical binding]; other site
709986000089	Walker B motif; other site
709986000090	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
709986000091	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
709986000092	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
709986000093	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
709986000094	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
709986000095	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
709986000096	NAD binding site [chemical binding]; other site
709986000097	homotetramer interface [polypeptide binding]; other site
709986000098	homodimer interface [polypeptide binding]; other site
709986000099	substrate binding site [chemical binding]; other site
709986000100	active site
709986000101	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
709986000102	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
709986000103	metal binding site [ion binding]; metal-binding site
709986000104	Protein of unknown function (DUF2945); Region: DUF2945; pfam11160
709986000105	tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036
709986000106	Yip1 domain; Region: Yip1; cl17815
709986000107	excinuclease ABC subunit B; Provisional; Region: PRK05298
709986000108	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
709986000109	ATP binding site [chemical binding]; other site
709986000110	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
709986000111	nucleotide binding region [chemical binding]; other site
709986000112	ATP-binding site [chemical binding]; other site
709986000113	Ultra-violet resistance protein B; Region: UvrB; pfam12344
709986000114	UvrB/uvrC motif; Region: UVR; pfam02151
709986000115	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
709986000116	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
709986000117	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133
709986000118	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
709986000119	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
709986000120	active site
709986000121	catalytic site [active]
709986000122	substrate binding site [chemical binding]; other site
709986000123	Domain of unknown function (DUF1802); Region: DUF1802; pfam08819
709986000124	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
709986000125	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
709986000126	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
709986000127	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
709986000128	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
709986000129	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
709986000130	oligomer interface [polypeptide binding]; other site
709986000131	active site residues [active]
709986000132	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
709986000133	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
709986000134	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
709986000135	Walker A motif; other site
709986000136	ATP binding site [chemical binding]; other site
709986000137	Walker B motif; other site
709986000138	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
709986000139	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
709986000140	Found in ATP-dependent protease La (LON); Region: LON; smart00464
709986000141	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
709986000142	Walker A motif; other site
709986000143	ATP binding site [chemical binding]; other site
709986000144	Walker B motif; other site
709986000145	arginine finger; other site
709986000146	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
709986000147	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
709986000148	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
709986000149	active site
709986000150	catalytic site [active]
709986000151	substrate binding site [chemical binding]; other site
709986000152	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
709986000153	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
709986000154	GatB domain; Region: GatB_Yqey; smart00845
709986000155	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
709986000156	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
709986000157	pyridoxal 5'-phosphate binding site [chemical binding]; other site
709986000158	homodimer interface [polypeptide binding]; other site
709986000159	catalytic residue [active]
709986000160	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
709986000161	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
709986000162	intersubunit interface [polypeptide binding]; other site
709986000163	active site
709986000164	zinc binding site [ion binding]; other site
709986000165	Na+ binding site [ion binding]; other site
709986000166	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
709986000167	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
709986000168	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
709986000169	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
709986000170	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
709986000171	effector binding site; other site
709986000172	dimer interface [polypeptide binding]; other site
709986000173	active site
709986000174	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
709986000175	TSCPD domain; Region: TSCPD; pfam12637
709986000176	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
709986000177	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
709986000178	active site
709986000179	catalytic tetrad [active]
709986000180	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
709986000181	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
709986000182	catalytic residue [active]
709986000183	HRDC domain; Region: HRDC; pfam00570
709986000184	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
709986000185	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
709986000186	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
709986000187	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
709986000188	cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04135
709986000189	cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200
709986000190	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
709986000191	active site
709986000192	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
709986000193	classical (c) SDRs; Region: SDR_c; cd05233
709986000194	NAD(P) binding site [chemical binding]; other site
709986000195	active site
709986000196	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
709986000197	Metallopeptidase family M24; Region: Peptidase_M24; pfam00557
709986000198	active site
709986000199	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
709986000200	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
709986000201	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
709986000202	peptide binding site [polypeptide binding]; other site
709986000203	dimer interface [polypeptide binding]; other site
709986000204	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
709986000205	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986000206	dimer interface [polypeptide binding]; other site
709986000207	conserved gate region; other site
709986000208	putative PBP binding loops; other site
709986000209	ABC-ATPase subunit interface; other site
709986000210	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
709986000211	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
709986000212	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986000213	dimer interface [polypeptide binding]; other site
709986000214	conserved gate region; other site
709986000215	putative PBP binding loops; other site
709986000216	ABC-ATPase subunit interface; other site
709986000217	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
709986000218	active site
709986000219	putative DNA-binding cleft [nucleotide binding]; other site
709986000220	dimer interface [polypeptide binding]; other site
709986000221	Protease prsW family; Region: PrsW-protease; pfam13367
709986000222	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
709986000223	MoaE interaction surface [polypeptide binding]; other site
709986000224	MoeB interaction surface [polypeptide binding]; other site
709986000225	thiocarboxylated glycine; other site
709986000226	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
709986000227	MoaE homodimer interface [polypeptide binding]; other site
709986000228	MoaD interaction [polypeptide binding]; other site
709986000229	active site residues [active]
709986000230	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
709986000231	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986000232	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986000233	metal binding site [ion binding]; metal-binding site
709986000234	active site
709986000235	I-site; other site
709986000236	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
709986000237	GAF domain; Region: GAF; pfam01590
709986000238	GXWXG protein; Region: GXWXG; pfam14231
709986000239	Domain of unknown function (DUF4334); Region: DUF4334; pfam14232
709986000240	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
709986000241	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986000242	dimer interface [polypeptide binding]; other site
709986000243	conserved gate region; other site
709986000244	putative PBP binding loops; other site
709986000245	ABC-ATPase subunit interface; other site
709986000246	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986000247	putative PBP binding loops; other site
709986000248	ABC-ATPase subunit interface; other site
709986000249	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
709986000250	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
709986000251	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
709986000252	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
709986000253	active site
709986000254	catalytic site [active]
709986000255	metal binding site [ion binding]; metal-binding site
709986000256	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
709986000257	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
709986000258	DNA-binding site [nucleotide binding]; DNA binding site
709986000259	UTRA domain; Region: UTRA; pfam07702
709986000260	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
709986000261	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
709986000262	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
709986000263	dimer interface [polypeptide binding]; other site
709986000264	active site
709986000265	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
709986000266	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
709986000267	substrate binding site [chemical binding]; other site
709986000268	ATP binding site [chemical binding]; other site
709986000269	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
709986000270	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
709986000271	substrate binding pocket [chemical binding]; other site
709986000272	membrane-bound complex binding site; other site
709986000273	hinge residues; other site
709986000274	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
709986000275	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
709986000276	active site
709986000277	catalytic tetrad [active]
709986000278	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
709986000279	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
709986000280	NADP binding site [chemical binding]; other site
709986000281	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
709986000282	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
709986000283	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
709986000284	GAF domain; Region: GAF; pfam01590
709986000285	GAF domain; Region: GAF_3; pfam13492
709986000286	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
709986000287	dimer interface [polypeptide binding]; other site
709986000288	phosphorylation site [posttranslational modification]
709986000289	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986000290	ATP binding site [chemical binding]; other site
709986000291	Mg2+ binding site [ion binding]; other site
709986000292	G-X-G motif; other site
709986000293	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
709986000294	Low molecular weight phosphatase family; Region: LMWPc; cd00115
709986000295	active site
709986000296	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
709986000297	dimerization interface [polypeptide binding]; other site
709986000298	putative DNA binding site [nucleotide binding]; other site
709986000299	putative Zn2+ binding site [ion binding]; other site
709986000300	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318
709986000301	gating phenylalanine in ion channel; other site
709986000302	Transcriptional regulator [Transcription]; Region: LysR; COG0583
709986000303	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
709986000304	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
709986000305	putative dimerization interface [polypeptide binding]; other site
709986000306	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
709986000307	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
709986000308	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
709986000309	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
709986000310	dimerization interface [polypeptide binding]; other site
709986000311	metal binding site [ion binding]; metal-binding site
709986000312	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
709986000313	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
709986000314	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
709986000315	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
709986000316	type III secretion protein GogB; Provisional; Region: PRK15386
709986000317	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
709986000318	FeS/SAM binding site; other site
709986000319	coproporphyrinogen III oxidase; Validated; Region: PRK08208
709986000320	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
709986000321	FeS/SAM binding site; other site
709986000322	Sulfatase; Region: Sulfatase; cl17466
709986000323	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
709986000324	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986000325	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986000326	metal binding site [ion binding]; metal-binding site
709986000327	active site
709986000328	I-site; other site
709986000329	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
709986000330	S-adenosylmethionine binding site [chemical binding]; other site
709986000331	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
709986000332	TPR motif; other site
709986000333	Tetratricopeptide repeat; Region: TPR_12; pfam13424
709986000334	binding surface
709986000335	Tetratricopeptide repeat; Region: TPR_12; pfam13424
709986000336	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
709986000337	binding surface
709986000338	TPR motif; other site
709986000339	Tetratricopeptide repeat; Region: TPR_12; pfam13424
709986000340	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
709986000341	binding surface
709986000342	TPR motif; other site
709986000343	Tetratricopeptide repeat; Region: TPR_12; pfam13424
709986000344	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986000345	metal binding site [ion binding]; metal-binding site
709986000346	active site
709986000347	I-site; other site
709986000348	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
709986000349	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
709986000350	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
709986000351	ligand binding site [chemical binding]; other site
709986000352	flexible hinge region; other site
709986000353	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
709986000354	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
709986000355	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
709986000356	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
709986000357	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
709986000358	GAF domain; Region: GAF; pfam01590
709986000359	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986000360	PAS domain; Region: PAS_9; pfam13426
709986000361	putative active site [active]
709986000362	heme pocket [chemical binding]; other site
709986000363	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986000364	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986000365	metal binding site [ion binding]; metal-binding site
709986000366	active site
709986000367	I-site; other site
709986000368	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
709986000369	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
709986000370	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
709986000371	active site
709986000372	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
709986000373	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
709986000374	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
709986000375	PAS fold; Region: PAS_4; pfam08448
709986000376	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986000377	putative active site [active]
709986000378	heme pocket [chemical binding]; other site
709986000379	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
709986000380	dimer interface [polypeptide binding]; other site
709986000381	phosphorylation site [posttranslational modification]
709986000382	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986000383	ATP binding site [chemical binding]; other site
709986000384	Mg2+ binding site [ion binding]; other site
709986000385	G-X-G motif; other site
709986000386	thiamine pyrophosphate protein; Provisional; Region: PRK08273
709986000387	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
709986000388	PYR/PP interface [polypeptide binding]; other site
709986000389	dimer interface [polypeptide binding]; other site
709986000390	tetramer interface [polypeptide binding]; other site
709986000391	TPP binding site [chemical binding]; other site
709986000392	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
709986000393	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
709986000394	TPP-binding site [chemical binding]; other site
709986000395	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
709986000396	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
709986000397	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
709986000398	active site residue [active]
709986000399	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
709986000400	active site residue [active]
709986000401	Transcriptional regulator [Transcription]; Region: LysR; COG0583
709986000402	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
709986000403	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
709986000404	dimerization interface [polypeptide binding]; other site
709986000405	CHASE3 domain; Region: CHASE3; pfam05227
709986000406	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
709986000407	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
709986000408	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986000409	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986000410	metal binding site [ion binding]; metal-binding site
709986000411	active site
709986000412	I-site; other site
709986000413	Helix-turn-helix domain; Region: HTH_18; pfam12833
709986000414	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
709986000415	Major Facilitator Superfamily; Region: MFS_1; pfam07690
709986000416	putative substrate translocation pore; other site
709986000417	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
709986000418	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
709986000419	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
709986000420	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
709986000421	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
709986000422	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314
709986000423	Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935
709986000424	acyl-activating enzyme (AAE) consensus motif; other site
709986000425	putative AMP binding site [chemical binding]; other site
709986000426	putative active site [active]
709986000427	putative CoA binding site [chemical binding]; other site
709986000428	Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
709986000429	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
709986000430	active site
709986000431	metal binding site [ion binding]; metal-binding site
709986000432	Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310
709986000433	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
709986000434	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
709986000435	ligand binding site [chemical binding]; other site
709986000436	metal binding site [ion binding]; metal-binding site
709986000437	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
709986000438	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
709986000439	dimer interface [polypeptide binding]; other site
709986000440	phosphorylation site [posttranslational modification]
709986000441	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986000442	ATP binding site [chemical binding]; other site
709986000443	Mg2+ binding site [ion binding]; other site
709986000444	G-X-G motif; other site
709986000445	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
709986000446	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986000447	active site
709986000448	phosphorylation site [posttranslational modification]
709986000449	intermolecular recognition site; other site
709986000450	dimerization interface [polypeptide binding]; other site
709986000451	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
709986000452	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986000453	putative active site [active]
709986000454	heme pocket [chemical binding]; other site
709986000455	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
709986000456	dimer interface [polypeptide binding]; other site
709986000457	phosphorylation site [posttranslational modification]
709986000458	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986000459	ATP binding site [chemical binding]; other site
709986000460	Mg2+ binding site [ion binding]; other site
709986000461	G-X-G motif; other site
709986000462	OsmC-like protein; Region: OsmC; cl00767
709986000463	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
709986000464	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
709986000465	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
709986000466	dimerization interface [polypeptide binding]; other site
709986000467	substrate binding pocket [chemical binding]; other site
709986000468	Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999
709986000469	putative substrate binding site [chemical binding]; other site
709986000470	active site
709986000471	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
709986000472	active site
709986000473	catalytic residues [active]
709986000474	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
709986000475	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
709986000476	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
709986000477	putative active site [active]
709986000478	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
709986000479	GAF domain; Region: GAF; pfam01590
709986000480	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986000481	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986000482	metal binding site [ion binding]; metal-binding site
709986000483	active site
709986000484	I-site; other site
709986000485	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
709986000486	Transcriptional regulators [Transcription]; Region: PurR; COG1609
709986000487	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
709986000488	DNA binding site [nucleotide binding]
709986000489	domain linker motif; other site
709986000490	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
709986000491	ligand binding site [chemical binding]; other site
709986000492	dimerization interface [polypeptide binding]; other site
709986000493	Chain length determinant protein; Region: Wzz; cl15801
709986000494	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
709986000495	Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513
709986000496	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
709986000497	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
709986000498	Probable Catalytic site; other site
709986000499	metal-binding site
709986000500	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
709986000501	trimer interface [polypeptide binding]; other site
709986000502	active site
709986000503	substrate binding site [chemical binding]; other site
709986000504	CoA binding site [chemical binding]; other site
709986000505	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
709986000506	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
709986000507	Walker A/P-loop; other site
709986000508	ATP binding site [chemical binding]; other site
709986000509	Q-loop/lid; other site
709986000510	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
709986000511	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
709986000512	Walker A/P-loop; other site
709986000513	ATP binding site [chemical binding]; other site
709986000514	Q-loop/lid; other site
709986000515	ABC transporter signature motif; other site
709986000516	Walker B; other site
709986000517	D-loop; other site
709986000518	H-loop/switch region; other site
709986000519	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
709986000520	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
709986000521	Right handed beta helix region; Region: Beta_helix; pfam13229
709986000522	Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022
709986000523	Bacterial sugar transferase; Region: Bac_transf; pfam02397
709986000524	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
709986000525	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
709986000526	NAD binding site [chemical binding]; other site
709986000527	putative substrate binding site 2 [chemical binding]; other site
709986000528	putative substrate binding site 1 [chemical binding]; other site
709986000529	active site
709986000530	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
709986000531	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
709986000532	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
709986000533	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
709986000534	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
709986000535	putative ADP-binding pocket [chemical binding]; other site
709986000536	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
709986000537	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
709986000538	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
709986000539	active site
709986000540	dimer interface [polypeptide binding]; other site
709986000541	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
709986000542	Ligand Binding Site [chemical binding]; other site
709986000543	Molecular Tunnel; other site
709986000544	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
709986000545	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
709986000546	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
709986000547	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
709986000548	Right handed beta helix region; Region: Beta_helix; pfam13229
709986000549	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
709986000550	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
709986000551	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
709986000552	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
709986000553	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
709986000554	extended (e) SDRs; Region: SDR_e; cd08946
709986000555	NAD(P) binding site [chemical binding]; other site
709986000556	active site
709986000557	substrate binding site [chemical binding]; other site
709986000558	Predicted dehydrogenase [General function prediction only]; Region: COG0579
709986000559	hydroxyglutarate oxidase; Provisional; Region: PRK11728
709986000560	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
709986000561	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
709986000562	substrate binding site; other site
709986000563	GAF domain; Region: GAF; pfam01590
709986000564	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986000565	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986000566	metal binding site [ion binding]; metal-binding site
709986000567	active site
709986000568	I-site; other site
709986000569	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
709986000570	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
709986000571	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
709986000572	catalytic triad [active]
709986000573	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
709986000574	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
709986000575	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
709986000576	catalytic residue [active]
709986000577	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986000578	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986000579	metal binding site [ion binding]; metal-binding site
709986000580	active site
709986000581	I-site; other site
709986000582	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
709986000583	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
709986000584	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
709986000585	active site
709986000586	catalytic residues [active]
709986000587	DNA binding site [nucleotide binding]
709986000588	Int/Topo IB signature motif; other site
709986000589	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
709986000590	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
709986000591	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
709986000592	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
709986000593	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
709986000594	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
709986000595	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
709986000596	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
709986000597	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
709986000598	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
709986000599	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
709986000600	isochorismate synthase DhbC; Validated; Region: PRK06923
709986000601	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
709986000602	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
709986000603	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
709986000604	acyl-activating enzyme (AAE) consensus motif; other site
709986000605	active site
709986000606	AMP binding site [chemical binding]; other site
709986000607	substrate binding site [chemical binding]; other site
709986000608	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
709986000609	Isochorismatase family; Region: Isochorismatase; pfam00857
709986000610	catalytic triad [active]
709986000611	conserved cis-peptide bond; other site
709986000612	Condensation domain; Region: Condensation; pfam00668
709986000613	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
709986000614	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
709986000615	NAD(P) binding site [chemical binding]; other site
709986000616	active site
709986000617	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
709986000618	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
709986000619	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
709986000620	putative homodimer interface [polypeptide binding]; other site
709986000621	putative homotetramer interface [polypeptide binding]; other site
709986000622	putative allosteric switch controlling residues; other site
709986000623	putative metal binding site [ion binding]; other site
709986000624	putative homodimer-homodimer interface [polypeptide binding]; other site
709986000625	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
709986000626	Rhodanese-like domain; Region: Rhodanese; pfam00581
709986000627	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
709986000628	active site residue [active]
709986000629	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
709986000630	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
709986000631	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
709986000632	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
709986000633	ABC transporter signature motif; other site
709986000634	Walker B; other site
709986000635	D-loop; other site
709986000636	H-loop/switch region; other site
709986000637	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
709986000638	Walker A/P-loop; other site
709986000639	ATP binding site [chemical binding]; other site
709986000640	Q-loop/lid; other site
709986000641	ABC transporter signature motif; other site
709986000642	Walker B; other site
709986000643	D-loop; other site
709986000644	H-loop/switch region; other site
709986000645	acetyl-CoA synthetase; Provisional; Region: PRK00174
709986000646	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
709986000647	active site
709986000648	CoA binding site [chemical binding]; other site
709986000649	acyl-activating enzyme (AAE) consensus motif; other site
709986000650	AMP binding site [chemical binding]; other site
709986000651	acetate binding site [chemical binding]; other site
709986000652	RibD C-terminal domain; Region: RibD_C; cl17279
709986000653	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
709986000654	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
709986000655	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
709986000656	Walker A/P-loop; other site
709986000657	ATP binding site [chemical binding]; other site
709986000658	Q-loop/lid; other site
709986000659	ABC transporter signature motif; other site
709986000660	Walker B; other site
709986000661	D-loop; other site
709986000662	H-loop/switch region; other site
709986000663	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
709986000664	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986000665	dimer interface [polypeptide binding]; other site
709986000666	conserved gate region; other site
709986000667	putative PBP binding loops; other site
709986000668	ABC-ATPase subunit interface; other site
709986000669	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
709986000670	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
709986000671	substrate binding pocket [chemical binding]; other site
709986000672	membrane-bound complex binding site; other site
709986000673	hinge residues; other site
709986000674	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
709986000675	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
709986000676	active site
709986000677	dimer interface [polypeptide binding]; other site
709986000678	non-prolyl cis peptide bond; other site
709986000679	insertion regions; other site
709986000680	High-affinity nickel-transport protein; Region: NicO; cl00964
709986000681	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
709986000682	active site
709986000683	putative homodimer interface [polypeptide binding]; other site
709986000684	SAM binding site [chemical binding]; other site
709986000685	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
709986000686	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
709986000687	putative active site [active]
709986000688	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
709986000689	putative active site [active]
709986000690	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
709986000691	Precorrin-8X methylmutase; Region: CbiC; pfam02570
709986000692	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
709986000693	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
709986000694	active site
709986000695	SAM binding site [chemical binding]; other site
709986000696	homodimer interface [polypeptide binding]; other site
709986000697	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
709986000698	active site
709986000699	SAM binding site [chemical binding]; other site
709986000700	homodimer interface [polypeptide binding]; other site
709986000701	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
709986000702	cobalamin biosynthesis protein CbiG; Provisional; Region: PRK07027
709986000703	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
709986000704	active site
709986000705	SAM binding site [chemical binding]; other site
709986000706	homodimer interface [polypeptide binding]; other site
709986000707	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
709986000708	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
709986000709	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
709986000710	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
709986000711	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
709986000712	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
709986000713	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
709986000714	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
709986000715	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
709986000716	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
709986000717	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
709986000718	Walker A motif; other site
709986000719	ATP binding site [chemical binding]; other site
709986000720	Walker B motif; other site
709986000721	arginine finger; other site
709986000722	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
709986000723	metal ion-dependent adhesion site (MIDAS); other site
709986000724	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
709986000725	Ligand Binding Site [chemical binding]; other site
709986000726	Transcriptional regulators [Transcription]; Region: MarR; COG1846
709986000727	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
709986000728	dimerization interface [polypeptide binding]; other site
709986000729	putative Zn2+ binding site [ion binding]; other site
709986000730	putative DNA binding site [nucleotide binding]; other site
709986000731	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
709986000732	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
709986000733	Cupin; Region: Cupin_6; pfam12852
709986000734	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
709986000735	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
709986000736	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
709986000737	Major Facilitator Superfamily; Region: MFS_1; pfam07690
709986000738	putative substrate translocation pore; other site
709986000739	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
709986000740	Cytochrome c553 [Energy production and conversion]; Region: COG2863
709986000741	Cytochrome c; Region: Cytochrom_C; cl11414
709986000742	Domain of unknown function (DUF1864); Region: DUF1864; pfam08933
709986000743	hypothetical protein; Provisional; Region: PRK07538
709986000744	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
709986000745	Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368
709986000746	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
709986000747	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
709986000748	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
709986000749	NAD(P) binding site [chemical binding]; other site
709986000750	active site
709986000751	putative acetyltransferase; Provisional; Region: PRK03624
709986000752	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
709986000753	Coenzyme A binding pocket [chemical binding]; other site
709986000754	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
709986000755	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
709986000756	NAD(P) binding site [chemical binding]; other site
709986000757	active site
709986000758	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
709986000759	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
709986000760	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
709986000761	Walker A/P-loop; other site
709986000762	ATP binding site [chemical binding]; other site
709986000763	Q-loop/lid; other site
709986000764	ABC transporter signature motif; other site
709986000765	Walker B; other site
709986000766	D-loop; other site
709986000767	H-loop/switch region; other site
709986000768	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
709986000769	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
709986000770	tetramer interface [polypeptide binding]; other site
709986000771	active site
709986000772	Mg2+/Mn2+ binding site [ion binding]; other site
709986000773	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
709986000774	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
709986000775	META domain; Region: META; cl01245
709986000776	Tetratricopeptide repeat; Region: TPR_12; pfam13424
709986000777	Tetratricopeptide repeat; Region: TPR_12; pfam13424
709986000778	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986000779	metal binding site [ion binding]; metal-binding site
709986000780	active site
709986000781	I-site; other site
709986000782	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
709986000783	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
709986000784	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986000785	active site
709986000786	phosphorylation site [posttranslational modification]
709986000787	intermolecular recognition site; other site
709986000788	dimerization interface [polypeptide binding]; other site
709986000789	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
709986000790	DNA binding site [nucleotide binding]
709986000791	HAMP domain; Region: HAMP; pfam00672
709986000792	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
709986000793	dimer interface [polypeptide binding]; other site
709986000794	phosphorylation site [posttranslational modification]
709986000795	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986000796	ATP binding site [chemical binding]; other site
709986000797	Mg2+ binding site [ion binding]; other site
709986000798	G-X-G motif; other site
709986000799	Transcriptional regulators [Transcription]; Region: PurR; COG1609
709986000800	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
709986000801	DNA binding site [nucleotide binding]
709986000802	domain linker motif; other site
709986000803	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
709986000804	dimerization interface [polypeptide binding]; other site
709986000805	ligand binding site [chemical binding]; other site
709986000806	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
709986000807	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
709986000808	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
709986000809	metal binding site [ion binding]; metal-binding site
709986000810	ligand binding site [chemical binding]; other site
709986000811	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
709986000812	The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509
709986000813	substrate binding site [chemical binding]; other site
709986000814	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
709986000815	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986000816	dimer interface [polypeptide binding]; other site
709986000817	conserved gate region; other site
709986000818	putative PBP binding loops; other site
709986000819	ABC-ATPase subunit interface; other site
709986000820	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
709986000821	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986000822	dimer interface [polypeptide binding]; other site
709986000823	conserved gate region; other site
709986000824	putative PBP binding loops; other site
709986000825	ABC-ATPase subunit interface; other site
709986000826	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
709986000827	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
709986000828	Walker A/P-loop; other site
709986000829	ATP binding site [chemical binding]; other site
709986000830	Q-loop/lid; other site
709986000831	ABC transporter signature motif; other site
709986000832	Walker B; other site
709986000833	D-loop; other site
709986000834	H-loop/switch region; other site
709986000835	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
709986000836	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
709986000837	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
709986000838	Walker A/P-loop; other site
709986000839	ATP binding site [chemical binding]; other site
709986000840	Q-loop/lid; other site
709986000841	ABC transporter signature motif; other site
709986000842	Walker B; other site
709986000843	D-loop; other site
709986000844	H-loop/switch region; other site
709986000845	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
709986000846	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
709986000847	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
709986000848	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
709986000849	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
709986000850	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
709986000851	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
709986000852	Walker A/P-loop; other site
709986000853	ATP binding site [chemical binding]; other site
709986000854	Q-loop/lid; other site
709986000855	ABC transporter signature motif; other site
709986000856	Walker B; other site
709986000857	D-loop; other site
709986000858	H-loop/switch region; other site
709986000859	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
709986000860	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
709986000861	ABC-ATPase subunit  interface; other site
709986000862	dimer interface [polypeptide binding]; other site
709986000863	putative PBP binding regions; other site
709986000864	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
709986000865	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
709986000866	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
709986000867	FAD binding pocket [chemical binding]; other site
709986000868	FAD binding motif [chemical binding]; other site
709986000869	phosphate binding motif [ion binding]; other site
709986000870	NAD binding pocket [chemical binding]; other site
709986000871	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
709986000872	Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998
709986000873	substrate binding site [chemical binding]; other site
709986000874	active site
709986000875	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
709986000876	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
709986000877	inhibitor binding site; inhibition site
709986000878	catalytic Zn binding site [ion binding]; other site
709986000879	structural Zn binding site [ion binding]; other site
709986000880	NADP binding site [chemical binding]; other site
709986000881	tetramer interface [polypeptide binding]; other site
709986000882	Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998
709986000883	substrate binding site [chemical binding]; other site
709986000884	active site
709986000885	L-arabinose isomerase; Provisional; Region: PRK02929
709986000886	L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557
709986000887	putative hexamer (dimer of trimers) interface [polypeptide binding]; other site
709986000888	trimer interface [polypeptide binding]; other site
709986000889	putative substrate binding site [chemical binding]; other site
709986000890	putative metal binding site [ion binding]; other site
709986000891	L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557
709986000892	intersubunit interface [polypeptide binding]; other site
709986000893	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
709986000894	active site
709986000895	Zn2+ binding site [ion binding]; other site
709986000896	ribulokinase; Provisional; Region: PRK04123
709986000897	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
709986000898	N- and C-terminal domain interface [polypeptide binding]; other site
709986000899	active site
709986000900	MgATP binding site [chemical binding]; other site
709986000901	catalytic site [active]
709986000902	metal binding site [ion binding]; metal-binding site
709986000903	carbohydrate binding site [chemical binding]; other site
709986000904	homodimer interface [polypeptide binding]; other site
709986000905	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
709986000906	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
709986000907	putative ligand binding site [chemical binding]; other site
709986000908	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
709986000909	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
709986000910	Walker A/P-loop; other site
709986000911	ATP binding site [chemical binding]; other site
709986000912	Q-loop/lid; other site
709986000913	ABC transporter signature motif; other site
709986000914	Walker B; other site
709986000915	D-loop; other site
709986000916	H-loop/switch region; other site
709986000917	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
709986000918	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
709986000919	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
709986000920	TM-ABC transporter signature motif; other site
709986000921	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
709986000922	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
709986000923	TM-ABC transporter signature motif; other site
709986000924	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
709986000925	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
709986000926	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
709986000927	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
709986000928	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
709986000929	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986000930	dimer interface [polypeptide binding]; other site
709986000931	conserved gate region; other site
709986000932	putative PBP binding loops; other site
709986000933	ABC-ATPase subunit interface; other site
709986000934	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
709986000935	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986000936	dimer interface [polypeptide binding]; other site
709986000937	conserved gate region; other site
709986000938	putative PBP binding loops; other site
709986000939	ABC-ATPase subunit interface; other site
709986000940	Transcriptional regulators [Transcription]; Region: PurR; COG1609
709986000941	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
709986000942	DNA binding site [nucleotide binding]
709986000943	domain linker motif; other site
709986000944	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
709986000945	ligand binding site [chemical binding]; other site
709986000946	dimerization interface (open form) [polypeptide binding]; other site
709986000947	dimerization interface (closed form) [polypeptide binding]; other site
709986000948	Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151
709986000949	putative homodimer interface [polypeptide binding]; other site
709986000950	putative homotetramer interface [polypeptide binding]; other site
709986000951	allosteric switch controlling residues; other site
709986000952	putative metal binding site [ion binding]; other site
709986000953	putative homodimer-homodimer interface [polypeptide binding]; other site
709986000954	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
709986000955	metal-binding site [ion binding]
709986000956	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
709986000957	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
709986000958	metal-binding site [ion binding]
709986000959	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
709986000960	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
709986000961	metal-binding site [ion binding]
709986000962	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
709986000963	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
709986000964	motif II; other site
709986000965	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
709986000966	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
709986000967	Major Facilitator Superfamily; Region: MFS_1; pfam07690
709986000968	putative substrate translocation pore; other site
709986000969	Response regulator receiver domain; Region: Response_reg; pfam00072
709986000970	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986000971	active site
709986000972	phosphorylation site [posttranslational modification]
709986000973	intermolecular recognition site; other site
709986000974	dimerization interface [polypeptide binding]; other site
709986000975	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
709986000976	Predicted GTPases [General function prediction only]; Region: COG1162
709986000977	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
709986000978	GTPase/Zn-binding domain interface [polypeptide binding]; other site
709986000979	GTP/Mg2+ binding site [chemical binding]; other site
709986000980	G4 box; other site
709986000981	G5 box; other site
709986000982	G1 box; other site
709986000983	Switch I region; other site
709986000984	G2 box; other site
709986000985	G3 box; other site
709986000986	Switch II region; other site
709986000987	GAF domain; Region: GAF_3; pfam13492
709986000988	GAF domain; Region: GAF_2; pfam13185
709986000989	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
709986000990	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
709986000991	Zn2+ binding site [ion binding]; other site
709986000992	Mg2+ binding site [ion binding]; other site
709986000993	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986000994	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986000995	metal binding site [ion binding]; metal-binding site
709986000996	active site
709986000997	I-site; other site
709986000998	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
709986000999	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
709986001000	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
709986001001	active site
709986001002	metal binding site [ion binding]; metal-binding site
709986001003	Transglycosylase; Region: Transgly; pfam00912
709986001004	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
709986001005	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
709986001006	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
709986001007	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
709986001008	putative dimer interface [polypeptide binding]; other site
709986001009	putative [2Fe-2S] cluster binding site [ion binding]; other site
709986001010	FecCD transport family; Region: FecCD; pfam01032
709986001011	ABC-ATPase subunit  interface; other site
709986001012	putative PBP binding regions; other site
709986001013	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
709986001014	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
709986001015	siderophore binding site; other site
709986001016	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
709986001017	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
709986001018	ABC-ATPase subunit  interface; other site
709986001019	dimer interface [polypeptide binding]; other site
709986001020	putative PBP binding regions; other site
709986001021	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
709986001022	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
709986001023	Walker A/P-loop; other site
709986001024	ATP binding site [chemical binding]; other site
709986001025	Q-loop/lid; other site
709986001026	ABC transporter signature motif; other site
709986001027	Walker B; other site
709986001028	D-loop; other site
709986001029	H-loop/switch region; other site
709986001030	GAF domain; Region: GAF_2; pfam13185
709986001031	GAF domain; Region: GAF_3; pfam13492
709986001032	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
709986001033	dimer interface [polypeptide binding]; other site
709986001034	phosphorylation site [posttranslational modification]
709986001035	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986001036	ATP binding site [chemical binding]; other site
709986001037	Mg2+ binding site [ion binding]; other site
709986001038	G-X-G motif; other site
709986001039	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
709986001040	active site
709986001041	catalytic triad [active]
709986001042	oxyanion hole [active]
709986001043	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
709986001044	Zn2+ binding site [ion binding]; other site
709986001045	Mg2+ binding site [ion binding]; other site
709986001046	Predicted kinase [General function prediction only]; Region: COG4639
709986001047	Predicted transcriptional regulator [Transcription]; Region: COG1959
709986001048	Transcriptional regulator; Region: Rrf2; pfam02082
709986001049	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
709986001050	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
709986001051	NADP binding site [chemical binding]; other site
709986001052	acetyl-CoA synthetase; Provisional; Region: PRK00174
709986001053	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
709986001054	acyl-activating enzyme (AAE) consensus motif; other site
709986001055	AMP binding site [chemical binding]; other site
709986001056	active site
709986001057	CoA binding site [chemical binding]; other site
709986001058	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
709986001059	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
709986001060	Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; cl01558
709986001061	ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558
709986001062	Hemin binding protein HutB.  These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149
709986001063	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
709986001064	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
709986001065	FAD binding pocket [chemical binding]; other site
709986001066	FAD binding motif [chemical binding]; other site
709986001067	phosphate binding motif [ion binding]; other site
709986001068	NAD binding pocket [chemical binding]; other site
709986001069	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986001070	PAS fold; Region: PAS_3; pfam08447
709986001071	putative active site [active]
709986001072	heme pocket [chemical binding]; other site
709986001073	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
709986001074	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986001075	putative active site [active]
709986001076	heme pocket [chemical binding]; other site
709986001077	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986001078	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
709986001079	putative active site [active]
709986001080	heme pocket [chemical binding]; other site
709986001081	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986001082	putative active site [active]
709986001083	heme pocket [chemical binding]; other site
709986001084	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986001085	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
709986001086	putative active site [active]
709986001087	heme pocket [chemical binding]; other site
709986001088	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986001089	putative active site [active]
709986001090	heme pocket [chemical binding]; other site
709986001091	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
709986001092	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986001093	ATP binding site [chemical binding]; other site
709986001094	Mg2+ binding site [ion binding]; other site
709986001095	G-X-G motif; other site
709986001096	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986001097	Response regulator receiver domain; Region: Response_reg; pfam00072
709986001098	active site
709986001099	phosphorylation site [posttranslational modification]
709986001100	intermolecular recognition site; other site
709986001101	dimerization interface [polypeptide binding]; other site
709986001102	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
709986001103	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986001104	putative active site [active]
709986001105	heme pocket [chemical binding]; other site
709986001106	PAS fold; Region: PAS_4; pfam08448
709986001107	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
709986001108	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986001109	ATP binding site [chemical binding]; other site
709986001110	Mg2+ binding site [ion binding]; other site
709986001111	G-X-G motif; other site
709986001112	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
709986001113	Amidase; Region: Amidase; cl11426
709986001114	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
709986001115	dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987
709986001116	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
709986001117	NADP binding site [chemical binding]; other site
709986001118	active site
709986001119	putative substrate binding site [chemical binding]; other site
709986001120	Domain of unknown function (DUF305); Region: DUF305; pfam03713
709986001121	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
709986001122	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986001123	active site
709986001124	phosphorylation site [posttranslational modification]
709986001125	intermolecular recognition site; other site
709986001126	dimerization interface [polypeptide binding]; other site
709986001127	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
709986001128	DNA binding site [nucleotide binding]
709986001129	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
709986001130	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
709986001131	dimerization interface [polypeptide binding]; other site
709986001132	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
709986001133	dimer interface [polypeptide binding]; other site
709986001134	phosphorylation site [posttranslational modification]
709986001135	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986001136	ATP binding site [chemical binding]; other site
709986001137	Mg2+ binding site [ion binding]; other site
709986001138	G-X-G motif; other site
709986001139	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
709986001140	G1 box; other site
709986001141	GTP/Mg2+ binding site [chemical binding]; other site
709986001142	G2 box; other site
709986001143	Switch I region; other site
709986001144	G3 box; other site
709986001145	Switch II region; other site
709986001146	G4 box; other site
709986001147	G5 box; other site
709986001148	Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018
709986001149	V4R domain; Region: V4R; cl15268
709986001150	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
709986001151	GAF domain; Region: GAF; pfam01590
709986001152	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
709986001153	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
709986001154	DNA binding site [nucleotide binding]
709986001155	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
709986001156	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
709986001157	MarR family; Region: MarR; pfam01047
709986001158	Predicted membrane protein [Function unknown]; Region: COG2259
709986001159	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
709986001160	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
709986001161	putative metal binding site [ion binding]; other site
709986001162	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
709986001163	active site
709986001164	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
709986001165	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
709986001166	NADP binding site [chemical binding]; other site
709986001167	dimer interface [polypeptide binding]; other site
709986001168	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
709986001169	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
709986001170	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
709986001171	Cation efflux family; Region: Cation_efflux; cl00316
709986001172	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
709986001173	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
709986001174	catalytic site [active]
709986001175	Predicted transcriptional regulators [Transcription]; Region: COG1695
709986001176	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
709986001177	Transcriptional regulators [Transcription]; Region: MarR; COG1846
709986001178	MarR family; Region: MarR_2; pfam12802
709986001179	MarR family; Region: MarR_2; cl17246
709986001180	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
709986001181	Permeases of the major facilitator superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / Inorganic ion transport and metabolism / General function prediction only]; Region: ProP; COG0477
709986001182	putative substrate translocation pore; other site
709986001183	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
709986001184	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
709986001185	intersubunit interface [polypeptide binding]; other site
709986001186	56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694
709986001187	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
709986001188	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
709986001189	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
709986001190	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
709986001191	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
709986001192	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
709986001193	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
709986001194	Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618
709986001195	pyruvate phosphate dikinase; Provisional; Region: PRK09279
709986001196	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
709986001197	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
709986001198	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
709986001199	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
709986001200	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
709986001201	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
709986001202	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
709986001203	GAF domain; Region: GAF; pfam01590
709986001204	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986001205	PAS domain; Region: PAS_9; pfam13426
709986001206	putative active site [active]
709986001207	heme pocket [chemical binding]; other site
709986001208	PAS fold; Region: PAS_4; pfam08448
709986001209	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
709986001210	putative active site [active]
709986001211	heme pocket [chemical binding]; other site
709986001212	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
709986001213	Zn2+ binding site [ion binding]; other site
709986001214	Mg2+ binding site [ion binding]; other site
709986001215	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
709986001216	GAF domain; Region: GAF; pfam01590
709986001217	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986001218	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986001219	metal binding site [ion binding]; metal-binding site
709986001220	active site
709986001221	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
709986001222	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
709986001223	putative substrate translocation pore; other site
709986001224	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
709986001225	MarR family; Region: MarR_2; pfam12802
709986001226	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
709986001227	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
709986001228	Phosphotransferase enzyme family; Region: APH; pfam01636
709986001229	active site
709986001230	ATP binding site [chemical binding]; other site
709986001231	antibiotic binding site [chemical binding]; other site
709986001232	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
709986001233	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
709986001234	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
709986001235	hypothetical protein; Provisional; Region: PRK06184
709986001236	Predicted membrane protein [Function unknown]; Region: COG1511
709986001237	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
709986001238	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
709986001239	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
709986001240	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
709986001241	Beta-lactamase; Region: Beta-lactamase; pfam00144
709986001242	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
709986001243	RNA ligase; Region: RNA_ligase; pfam09414
709986001244	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986001245	PAS fold; Region: PAS_3; pfam08447
709986001246	putative active site [active]
709986001247	heme pocket [chemical binding]; other site
709986001248	PAS domain; Region: PAS; smart00091
709986001249	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
709986001250	putative active site [active]
709986001251	heme pocket [chemical binding]; other site
709986001252	Nucleopolyhedrovirus P10 protein; Region: NPV_P10; cl17484
709986001253	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986001254	putative active site [active]
709986001255	heme pocket [chemical binding]; other site
709986001256	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
709986001257	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
709986001258	dimer interface [polypeptide binding]; other site
709986001259	phosphorylation site [posttranslational modification]
709986001260	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986001261	ATP binding site [chemical binding]; other site
709986001262	Mg2+ binding site [ion binding]; other site
709986001263	G-X-G motif; other site
709986001264	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
709986001265	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986001266	active site
709986001267	phosphorylation site [posttranslational modification]
709986001268	intermolecular recognition site; other site
709986001269	dimerization interface [polypeptide binding]; other site
709986001270	Domain of unknown function (DUF3369); Region: DUF3369; pfam11849
709986001271	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986001272	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986001273	metal binding site [ion binding]; metal-binding site
709986001274	active site
709986001275	I-site; other site
709986001276	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
709986001277	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
709986001278	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
709986001279	DXD motif; other site
709986001280	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413
709986001281	active site
709986001282	catalytic residues [active]
709986001283	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
709986001284	Putative catalytic NodB homology domain of uncharacterized prokaryotic polysaccharide deacetylases which consist of a 6-stranded beta/alpha barrel; Region: CE4_DAC_u1_6s; cd10970
709986001285	putative active site [active]
709986001286	putative metal binding site [ion binding]; other site
709986001287	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
709986001288	active site
709986001289	catalytic residues [active]
709986001290	Replication initiator protein A; Region: RPA; cl17860
709986001291	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
709986001292	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
709986001293	NAD(P) binding site [chemical binding]; other site
709986001294	active site
709986001295	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
709986001296	non-specific DNA binding site [nucleotide binding]; other site
709986001297	salt bridge; other site
709986001298	sequence-specific DNA binding site [nucleotide binding]; other site
709986001299	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
709986001300	Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998
709986001301	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
709986001302	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
709986001303	dimerization interface [polypeptide binding]; other site
709986001304	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
709986001305	dimer interface [polypeptide binding]; other site
709986001306	phosphorylation site [posttranslational modification]
709986001307	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986001308	ATP binding site [chemical binding]; other site
709986001309	Mg2+ binding site [ion binding]; other site
709986001310	G-X-G motif; other site
709986001311	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
709986001312	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986001313	active site
709986001314	phosphorylation site [posttranslational modification]
709986001315	intermolecular recognition site; other site
709986001316	dimerization interface [polypeptide binding]; other site
709986001317	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
709986001318	DNA binding site [nucleotide binding]
709986001319	YceI-like domain; Region: YceI; smart00867
709986001320	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
709986001321	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
709986001322	active site
709986001323	dimer interface [polypeptide binding]; other site
709986001324	non-prolyl cis peptide bond; other site
709986001325	insertion regions; other site
709986001326	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
709986001327	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
709986001328	aspartate racemase; Region: asp_race; TIGR00035
709986001329	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
709986001330	D-cysteine desulfhydrase; Validated; Region: PRK03910
709986001331	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
709986001332	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
709986001333	catalytic residue [active]
709986001334	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
709986001335	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
709986001336	homodimer interface [polypeptide binding]; other site
709986001337	substrate-cofactor binding pocket; other site
709986001338	catalytic residue [active]
709986001339	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
709986001340	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
709986001341	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
709986001342	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
709986001343	substrate binding site [chemical binding]; other site
709986001344	oxyanion hole (OAH) forming residues; other site
709986001345	trimer interface [polypeptide binding]; other site
709986001346	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
709986001347	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
709986001348	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
709986001349	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
709986001350	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
709986001351	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
709986001352	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
709986001353	Beta-lactamase; Region: Beta-lactamase; pfam00144
709986001354	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
709986001355	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
709986001356	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
709986001357	active site
709986001358	metal binding site [ion binding]; metal-binding site
709986001359	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
709986001360	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
709986001361	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
709986001362	P-loop; other site
709986001363	Magnesium ion binding site [ion binding]; other site
709986001364	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
709986001365	Family description; Region: UvrD_C_2; pfam13538
709986001366	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
709986001367	binding surface
709986001368	TPR motif; other site
709986001369	Tetratricopeptide repeat; Region: TPR_12; pfam13424
709986001370	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986001371	metal binding site [ion binding]; metal-binding site
709986001372	active site
709986001373	I-site; other site
709986001374	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
709986001375	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
709986001376	active site
709986001377	catalytic residues [active]
709986001378	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
709986001379	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
709986001380	active site
709986001381	catalytic tetrad [active]
709986001382	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
709986001383	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
709986001384	GAF domain; Region: GAF; pfam01590
709986001385	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
709986001386	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
709986001387	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
709986001388	DNA binding residues [nucleotide binding]
709986001389	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
709986001390	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
709986001391	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
709986001392	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
709986001393	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
709986001394	DNA topoisomerase I, bacterial; Region: topA_bact; TIGR01051
709986001395	active site
709986001396	interdomain interaction site; other site
709986001397	putative metal-binding site [ion binding]; other site
709986001398	nucleotide binding site [chemical binding]; other site
709986001399	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
709986001400	domain I; other site
709986001401	DNA binding groove [nucleotide binding]
709986001402	phosphate binding site [ion binding]; other site
709986001403	domain II; other site
709986001404	domain III; other site
709986001405	nucleotide binding site [chemical binding]; other site
709986001406	catalytic site [active]
709986001407	domain IV; other site
709986001408	DEAD-like helicases superfamily; Region: DEXDc; smart00487
709986001409	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
709986001410	ATP binding site [chemical binding]; other site
709986001411	putative Mg++ binding site [ion binding]; other site
709986001412	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
709986001413	nucleotide binding region [chemical binding]; other site
709986001414	ATP-binding site [chemical binding]; other site
709986001415	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
709986001416	Ligand Binding Site [chemical binding]; other site
709986001417	hypothetical protein; Provisional; Region: PRK06753
709986001418	hypothetical protein; Provisional; Region: PRK07236
709986001419	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
709986001420	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986001421	PAS domain; Region: PAS_9; pfam13426
709986001422	putative active site [active]
709986001423	heme pocket [chemical binding]; other site
709986001424	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
709986001425	GAF domain; Region: GAF; pfam01590
709986001426	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
709986001427	dimer interface [polypeptide binding]; other site
709986001428	phosphorylation site [posttranslational modification]
709986001429	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986001430	ATP binding site [chemical binding]; other site
709986001431	Mg2+ binding site [ion binding]; other site
709986001432	G-X-G motif; other site
709986001433	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
709986001434	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
709986001435	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
709986001436	putative metal binding site [ion binding]; other site
709986001437	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
709986001438	active site
709986001439	L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases.  It is thought...; Region: LMO_FMN; cd03332
709986001440	putative active site [active]
709986001441	putative substrate binding site [chemical binding]; other site
709986001442	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
709986001443	putative FMN binding site [chemical binding]; other site
709986001444	putative catalytic residues [active]
709986001445	DinB family; Region: DinB; cl17821
709986001446	DinB superfamily; Region: DinB_2; pfam12867
709986001447	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
709986001448	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
709986001449	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
709986001450	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
709986001451	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
709986001452	putative ligand binding site [chemical binding]; other site
709986001453	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
709986001454	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
709986001455	Walker A/P-loop; other site
709986001456	ATP binding site [chemical binding]; other site
709986001457	Q-loop/lid; other site
709986001458	ABC transporter signature motif; other site
709986001459	Walker B; other site
709986001460	D-loop; other site
709986001461	H-loop/switch region; other site
709986001462	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
709986001463	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
709986001464	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
709986001465	TM-ABC transporter signature motif; other site
709986001466	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
709986001467	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
709986001468	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
709986001469	TM-ABC transporter signature motif; other site
709986001470	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
709986001471	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
709986001472	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986001473	active site
709986001474	phosphorylation site [posttranslational modification]
709986001475	intermolecular recognition site; other site
709986001476	dimerization interface [polypeptide binding]; other site
709986001477	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
709986001478	DNA binding residues [nucleotide binding]
709986001479	dimerization interface [polypeptide binding]; other site
709986001480	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
709986001481	Histidine kinase; Region: HisKA_3; pfam07730
709986001482	GAF domain; Region: GAF_3; pfam13492
709986001483	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
709986001484	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
709986001485	dimer interface [polypeptide binding]; other site
709986001486	phosphorylation site [posttranslational modification]
709986001487	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986001488	ATP binding site [chemical binding]; other site
709986001489	Mg2+ binding site [ion binding]; other site
709986001490	G-X-G motif; other site
709986001491	Response regulator receiver domain; Region: Response_reg; pfam00072
709986001492	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986001493	active site
709986001494	phosphorylation site [posttranslational modification]
709986001495	intermolecular recognition site; other site
709986001496	dimerization interface [polypeptide binding]; other site
709986001497	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
709986001498	GAF domain; Region: GAF; pfam01590
709986001499	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
709986001500	dimer interface [polypeptide binding]; other site
709986001501	phosphorylation site [posttranslational modification]
709986001502	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986001503	ATP binding site [chemical binding]; other site
709986001504	Mg2+ binding site [ion binding]; other site
709986001505	G-X-G motif; other site
709986001506	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
709986001507	GAF domain; Region: GAF; pfam01590
709986001508	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
709986001509	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
709986001510	putative substrate translocation pore; other site
709986001511	acyl-CoA synthetase; Validated; Region: PRK07788
709986001512	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
709986001513	acyl-activating enzyme (AAE) consensus motif; other site
709986001514	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
709986001515	AMP binding site [chemical binding]; other site
709986001516	active site
709986001517	acyl-activating enzyme (AAE) consensus motif; other site
709986001518	CoA binding site [chemical binding]; other site
709986001519	putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730
709986001520	classical (c) SDRs; Region: SDR_c; cd05233
709986001521	NAD(P) binding site [chemical binding]; other site
709986001522	active site
709986001523	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
709986001524	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
709986001525	sequence-specific DNA binding site [nucleotide binding]; other site
709986001526	salt bridge; other site
709986001527	Cupin domain; Region: Cupin_2; cl17218
709986001528	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
709986001529	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
709986001530	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
709986001531	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
709986001532	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
709986001533	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
709986001534	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986001535	active site
709986001536	phosphorylation site [posttranslational modification]
709986001537	intermolecular recognition site; other site
709986001538	dimerization interface [polypeptide binding]; other site
709986001539	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
709986001540	DNA binding residues [nucleotide binding]
709986001541	dimerization interface [polypeptide binding]; other site
709986001542	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
709986001543	Histidine kinase; Region: HisKA_3; pfam07730
709986001544	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986001545	ATP binding site [chemical binding]; other site
709986001546	Mg2+ binding site [ion binding]; other site
709986001547	G-X-G motif; other site
709986001548	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
709986001549	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
709986001550	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
709986001551	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
709986001552	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
709986001553	catalytic residue [active]
709986001554	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
709986001555	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
709986001556	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
709986001557	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
709986001558	active site
709986001559	SAM binding site [chemical binding]; other site
709986001560	homodimer interface [polypeptide binding]; other site
709986001561	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
709986001562	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
709986001563	active site
709986001564	Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999
709986001565	putative substrate binding site [chemical binding]; other site
709986001566	active site
709986001567	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
709986001568	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986001569	dimer interface [polypeptide binding]; other site
709986001570	conserved gate region; other site
709986001571	putative PBP binding loops; other site
709986001572	ABC-ATPase subunit interface; other site
709986001573	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
709986001574	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986001575	dimer interface [polypeptide binding]; other site
709986001576	conserved gate region; other site
709986001577	putative PBP binding loops; other site
709986001578	ABC-ATPase subunit interface; other site
709986001579	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
709986001580	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
709986001581	Glycosyl hydrolase family 43; Region: GH43_bXyl_2; cd08991
709986001582	active site
709986001583	Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590
709986001584	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
709986001585	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
709986001586	Coenzyme A binding pocket [chemical binding]; other site
709986001587	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
709986001588	putative GTP cyclohydrolase; Provisional; Region: PRK13674
709986001589	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
709986001590	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
709986001591	GDP-binding site [chemical binding]; other site
709986001592	ACT binding site; other site
709986001593	IMP binding site; other site
709986001594	e3 binding domain; Region: E3_binding; pfam02817
709986001595	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
709986001596	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
709986001597	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
709986001598	NAD binding site [chemical binding]; other site
709986001599	Phe binding site; other site
709986001600	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
709986001601	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
709986001602	ATP-binding site [chemical binding]; other site
709986001603	Sugar specificity; other site
709986001604	Pyrimidine base specificity; other site
709986001605	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
709986001606	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
709986001607	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
709986001608	CoenzymeA binding site [chemical binding]; other site
709986001609	subunit interaction site [polypeptide binding]; other site
709986001610	PHB binding site; other site
709986001611	Protein of unknown function DUF91; Region: DUF91; cl00709
709986001612	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
709986001613	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
709986001614	NAD binding site [chemical binding]; other site
709986001615	catalytic Zn binding site [ion binding]; other site
709986001616	structural Zn binding site [ion binding]; other site
709986001617	Phytase; Region: Phytase; cl17685
709986001618	Protein of unknown function, DUF488; Region: DUF488; pfam04343
709986001619	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
709986001620	PHP domain; Region: PHP; pfam02811
709986001621	active site
709986001622	PHP Thumb interface [polypeptide binding]; other site
709986001623	metal binding site [ion binding]; metal-binding site
709986001624	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
709986001625	DNA polymerase III subunit alpha; Reviewed; Region: PRK07373
709986001626	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
709986001627	generic binding surface II; other site
709986001628	generic binding surface I; other site
709986001629	Predicted integral membrane protein [Function unknown]; Region: COG5530
709986001630	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
709986001631	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
709986001632	minor groove reading motif; other site
709986001633	helix-hairpin-helix signature motif; other site
709986001634	substrate binding pocket [chemical binding]; other site
709986001635	active site
709986001636	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
709986001637	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
709986001638	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
709986001639	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
709986001640	catalytic residue [active]
709986001641	putative FPP diphosphate  binding site; other site
709986001642	putative FPP binding hydrophobic cleft; other site
709986001643	dimer interface [polypeptide binding]; other site
709986001644	putative IPP diphosphate binding site; other site
709986001645	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
709986001646	active site
709986001647	DNA binding site [nucleotide binding]
709986001648	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
709986001649	Walker A/P-loop; other site
709986001650	ATP binding site [chemical binding]; other site
709986001651	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
709986001652	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
709986001653	catalytic residues [active]
709986001654	catalytic nucleophile [active]
709986001655	Recombinase; Region: Recombinase; pfam07508
709986001656	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
709986001657	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
709986001658	active site
709986001659	DNA binding site [nucleotide binding]
709986001660	Int/Topo IB signature motif; other site
709986001661	6-phosphofructokinase; Provisional; Region: PRK03202
709986001662	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
709986001663	active site
709986001664	ADP/pyrophosphate binding site [chemical binding]; other site
709986001665	dimerization interface [polypeptide binding]; other site
709986001666	allosteric effector site; other site
709986001667	fructose-1,6-bisphosphate binding site; other site
709986001668	Predicted methyltransferases [General function prediction only]; Region: COG0313
709986001669	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
709986001670	putative SAM binding site [chemical binding]; other site
709986001671	putative homodimer interface [polypeptide binding]; other site
709986001672	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
709986001673	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
709986001674	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
709986001675	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
709986001676	acetoacetyl-CoA reductase; Provisional; Region: PRK12824
709986001677	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
709986001678	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
709986001679	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
709986001680	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
709986001681	dimerization interface 3.5A [polypeptide binding]; other site
709986001682	active site
709986001683	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
709986001684	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
709986001685	TPP-binding site [chemical binding]; other site
709986001686	tetramer interface [polypeptide binding]; other site
709986001687	heterodimer interface [polypeptide binding]; other site
709986001688	phosphorylation loop region [posttranslational modification]
709986001689	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
709986001690	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
709986001691	alpha subunit interface [polypeptide binding]; other site
709986001692	TPP binding site [chemical binding]; other site
709986001693	heterodimer interface [polypeptide binding]; other site
709986001694	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
709986001695	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
709986001696	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
709986001697	E3 interaction surface; other site
709986001698	lipoyl attachment site [posttranslational modification]; other site
709986001699	e3 binding domain; Region: E3_binding; pfam02817
709986001700	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
709986001701	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
709986001702	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
709986001703	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
709986001704	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
709986001705	CutA1 divalent ion tolerance protein; Region: CutA1; pfam03091
709986001706	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
709986001707	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
709986001708	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
709986001709	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
709986001710	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl17581
709986001711	putative proton transfer pathway, P2; other site
709986001712	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861
709986001713	Haemolytic domain; Region: Haemolytic; cl00506
709986001714	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
709986001715	active sites [active]
709986001716	tetramer interface [polypeptide binding]; other site
709986001717	imidazolonepropionase; Validated; Region: PRK09356
709986001718	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
709986001719	active site
709986001720	agmatinase; Region: agmatinase; TIGR01230
709986001721	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
709986001722	active site
709986001723	metal binding site [ion binding]; metal-binding site
709986001724	urocanate hydratase; Provisional; Region: PRK05414
709986001725	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
709986001726	Transcriptional regulator [Transcription]; Region: IclR; COG1414
709986001727	Bacterial transcriptional regulator; Region: IclR; pfam01614
709986001728	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
709986001729	Cytochrome c; Region: Cytochrom_C; pfam00034
709986001730	PUA domain; Region: PUA; cl00607
709986001731	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
709986001732	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
709986001733	putative RNA binding site [nucleotide binding]; other site
709986001734	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
709986001735	S-adenosylmethionine binding site [chemical binding]; other site
709986001736	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
709986001737	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
709986001738	TrkA-C domain; Region: TrkA_C; pfam02080
709986001739	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
709986001740	metal binding site 2 [ion binding]; metal-binding site
709986001741	putative DNA binding helix; other site
709986001742	metal binding site 1 [ion binding]; metal-binding site
709986001743	dimer interface [polypeptide binding]; other site
709986001744	structural Zn2+ binding site [ion binding]; other site
709986001745	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
709986001746	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986001747	active site
709986001748	phosphorylation site [posttranslational modification]
709986001749	intermolecular recognition site; other site
709986001750	dimerization interface [polypeptide binding]; other site
709986001751	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
709986001752	DNA binding site [nucleotide binding]
709986001753	Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947
709986001754	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986001755	active site
709986001756	phosphorylation site [posttranslational modification]
709986001757	intermolecular recognition site; other site
709986001758	dimerization interface [polypeptide binding]; other site
709986001759	Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Region: RpsF; COG0360
709986001760	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
709986001761	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
709986001762	dimer interface [polypeptide binding]; other site
709986001763	ssDNA binding site [nucleotide binding]; other site
709986001764	tetramer (dimer of dimers) interface [polypeptide binding]; other site
709986001765	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
709986001766	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
709986001767	dimer interface [polypeptide binding]; other site
709986001768	ssDNA binding site [nucleotide binding]; other site
709986001769	tetramer (dimer of dimers) interface [polypeptide binding]; other site
709986001770	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
709986001771	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
709986001772	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
709986001773	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
709986001774	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
709986001775	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
709986001776	active site
709986001777	metal binding site [ion binding]; metal-binding site
709986001778	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
709986001779	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
709986001780	putative NAD(P) binding site [chemical binding]; other site
709986001781	active site
709986001782	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
709986001783	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
709986001784	TPP-binding site [chemical binding]; other site
709986001785	dimer interface [polypeptide binding]; other site
709986001786	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
709986001787	PYR/PP interface [polypeptide binding]; other site
709986001788	dimer interface [polypeptide binding]; other site
709986001789	TPP binding site [chemical binding]; other site
709986001790	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
709986001791	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
709986001792	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
709986001793	catalytic site [active]
709986001794	G-X2-G-X-G-K; other site
709986001795	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
709986001796	putative ADP-ribose binding site [chemical binding]; other site
709986001797	putative active site [active]
709986001798	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
709986001799	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
709986001800	minor groove reading motif; other site
709986001801	helix-hairpin-helix signature motif; other site
709986001802	active site
709986001803	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
709986001804	putative acyltransferase; Provisional; Region: PRK05790
709986001805	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
709986001806	dimer interface [polypeptide binding]; other site
709986001807	active site
709986001808	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
709986001809	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
709986001810	putative [4Fe-4S] binding site [ion binding]; other site
709986001811	putative molybdopterin cofactor binding site [chemical binding]; other site
709986001812	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
709986001813	putative molybdopterin cofactor binding site; other site
709986001814	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
709986001815	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
709986001816	dimer interface [polypeptide binding]; other site
709986001817	active site
709986001818	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
709986001819	dimer interface [polypeptide binding]; other site
709986001820	active site
709986001821	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
709986001822	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
709986001823	active site
709986001824	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
709986001825	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
709986001826	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
709986001827	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
709986001828	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
709986001829	dimerization domain swap beta strand [polypeptide binding]; other site
709986001830	regulatory protein interface [polypeptide binding]; other site
709986001831	active site
709986001832	regulatory phosphorylation site [posttranslational modification]; other site
709986001833	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
709986001834	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
709986001835	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
709986001836	active site turn [active]
709986001837	phosphorylation site [posttranslational modification]
709986001838	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
709986001839	HPr interaction site; other site
709986001840	glycerol kinase (GK) interaction site [polypeptide binding]; other site
709986001841	active site
709986001842	phosphorylation site [posttranslational modification]
709986001843	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
709986001844	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
709986001845	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
709986001846	putative active site [active]
709986001847	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
709986001848	Moco binding site; other site
709986001849	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
709986001850	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986001851	ATP binding site [chemical binding]; other site
709986001852	Mg2+ binding site [ion binding]; other site
709986001853	G-X-G motif; other site
709986001854	homoserine kinase; Provisional; Region: PRK01212
709986001855	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
709986001856	threonine synthase; Reviewed; Region: PRK06721
709986001857	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
709986001858	homodimer interface [polypeptide binding]; other site
709986001859	pyridoxal 5'-phosphate binding site [chemical binding]; other site
709986001860	catalytic residue [active]
709986001861	Predicted membrane protein [Function unknown]; Region: COG2261
709986001862	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
709986001863	lipoprotein signal peptidase; Provisional; Region: PRK14777
709986001864	S-ribosylhomocysteinase; Provisional; Region: PRK02260
709986001865	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
709986001866	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
709986001867	S-layer homology domain; Region: SLH; pfam00395
709986001868	Flagella accessory protein C (FlaC); Region: FlaC_arch; cl10488
709986001869	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
709986001870	DHH family; Region: DHH; pfam01368
709986001871	DHHA2 domain; Region: DHHA2; pfam02833
709986001872	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
709986001873	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
709986001874	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
709986001875	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
709986001876	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
709986001877	active site
709986001878	Zn binding site [ion binding]; other site
709986001879	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
709986001880	sequence-specific DNA binding site [nucleotide binding]; other site
709986001881	salt bridge; other site
709986001882	Arginase family; Region: Arginase; cd09989
709986001883	agmatinase; Region: agmatinase; TIGR01230
709986001884	active site
709986001885	Mn binding site [ion binding]; other site
709986001886	oligomer interface [polypeptide binding]; other site
709986001887	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
709986001888	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
709986001889	trimer interface [polypeptide binding]; other site
709986001890	dimer interface [polypeptide binding]; other site
709986001891	putative active site [active]
709986001892	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
709986001893	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
709986001894	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129
709986001895	catalytic triad [active]
709986001896	active site nucleophile [active]
709986001897	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
709986001898	nudix motif; other site
709986001899	ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448
709986001900	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
709986001901	ligand binding site; other site
709986001902	oligomer interface; other site
709986001903	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
709986001904	dimer interface [polypeptide binding]; other site
709986001905	N-terminal domain interface [polypeptide binding]; other site
709986001906	sulfate 1 binding site; other site
709986001907	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
709986001908	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
709986001909	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
709986001910	dimer interface [polypeptide binding]; other site
709986001911	[2Fe-2S] cluster binding site [ion binding]; other site
709986001912	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
709986001913	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
709986001914	S-adenosylmethionine binding site [chemical binding]; other site
709986001915	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14618
709986001916	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
709986001917	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
709986001918	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
709986001919	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
709986001920	von Willebrand factor (vWF) type A domain; Region: VWA; smart00327
709986001921	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
709986001922	putative metal binding site [ion binding]; other site
709986001923	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
709986001924	RNB domain; Region: RNB; pfam00773
709986001925	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3877
709986001926	Domain of unknown function (DUF1990); Region: DUF1990; pfam09348
709986001927	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
709986001928	active site
709986001929	catalytic residues [active]
709986001930	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
709986001931	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
709986001932	dimerization interface [polypeptide binding]; other site
709986001933	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
709986001934	dimer interface [polypeptide binding]; other site
709986001935	phosphorylation site [posttranslational modification]
709986001936	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986001937	ATP binding site [chemical binding]; other site
709986001938	Mg2+ binding site [ion binding]; other site
709986001939	G-X-G motif; other site
709986001940	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
709986001941	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986001942	active site
709986001943	phosphorylation site [posttranslational modification]
709986001944	intermolecular recognition site; other site
709986001945	dimerization interface [polypeptide binding]; other site
709986001946	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
709986001947	DNA binding site [nucleotide binding]
709986001948	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
709986001949	cyclase homology domain; Region: CHD; cd07302
709986001950	nucleotidyl binding site; other site
709986001951	metal binding site [ion binding]; metal-binding site
709986001952	dimer interface [polypeptide binding]; other site
709986001953	putative 4-hydroxybenzoate polyprenyltransferase; Region: ubiA_other; TIGR01475
709986001954	UbiA prenyltransferase family; Region: UbiA; pfam01040
709986001955	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370
709986001956	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
709986001957	putative substrate translocation pore; other site
709986001958	Major Facilitator Superfamily; Region: MFS_1; pfam07690
709986001959	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
709986001960	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
709986001961	active site
709986001962	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
709986001963	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
709986001964	putative ADP-binding pocket [chemical binding]; other site
709986001965	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
709986001966	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
709986001967	GTP-binding protein LepA; Provisional; Region: PRK05433
709986001968	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
709986001969	G1 box; other site
709986001970	putative GEF interaction site [polypeptide binding]; other site
709986001971	GTP/Mg2+ binding site [chemical binding]; other site
709986001972	Switch I region; other site
709986001973	G2 box; other site
709986001974	G3 box; other site
709986001975	Switch II region; other site
709986001976	G4 box; other site
709986001977	G5 box; other site
709986001978	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
709986001979	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
709986001980	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
709986001981	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
709986001982	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986001983	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986001984	metal binding site [ion binding]; metal-binding site
709986001985	active site
709986001986	I-site; other site
709986001987	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
709986001988	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
709986001989	dimer interface [polypeptide binding]; other site
709986001990	phosphorylation site [posttranslational modification]
709986001991	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986001992	ATP binding site [chemical binding]; other site
709986001993	Mg2+ binding site [ion binding]; other site
709986001994	G-X-G motif; other site
709986001995	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
709986001996	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986001997	active site
709986001998	phosphorylation site [posttranslational modification]
709986001999	intermolecular recognition site; other site
709986002000	dimerization interface [polypeptide binding]; other site
709986002001	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
709986002002	DNA binding residues [nucleotide binding]
709986002003	dimerization interface [polypeptide binding]; other site
709986002004	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
709986002005	Predicted amidohydrolase [General function prediction only]; Region: COG0388
709986002006	active site
709986002007	catalytic triad [active]
709986002008	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
709986002009	16S/18S rRNA binding site [nucleotide binding]; other site
709986002010	S13e-L30e interaction site [polypeptide binding]; other site
709986002011	25S rRNA binding site [nucleotide binding]; other site
709986002012	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
709986002013	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
709986002014	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
709986002015	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
709986002016	ligand binding site [chemical binding]; other site
709986002017	active site
709986002018	UGI interface [polypeptide binding]; other site
709986002019	catalytic site [active]
709986002020	hypothetical protein; Provisional; Region: PRK06446
709986002021	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681
709986002022	metal binding site [ion binding]; metal-binding site
709986002023	dimer interface [polypeptide binding]; other site
709986002024	Phosphotransferase enzyme family; Region: APH; pfam01636
709986002025	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
709986002026	active site
709986002027	ATP binding site [chemical binding]; other site
709986002028	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
709986002029	putative active site pocket [active]
709986002030	cleavage site
709986002031	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
709986002032	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
709986002033	active site
709986002034	catalytic site [active]
709986002035	Predicted metalloprotease [General function prediction only]; Region: COG2321
709986002036	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
709986002037	Protein of unknown function DUF45; Region: DUF45; pfam01863
709986002038	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
709986002039	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
709986002040	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
709986002041	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
709986002042	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
709986002043	dimer interface [polypeptide binding]; other site
709986002044	catalytic triad [active]
709986002045	Predicted membrane protein [Function unknown]; Region: COG2860
709986002046	UPF0126 domain; Region: UPF0126; pfam03458
709986002047	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
709986002048	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
709986002049	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
709986002050	active site
709986002051	Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350
709986002052	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
709986002053	active site
709986002054	dimer interfaces [polypeptide binding]; other site
709986002055	catalytic residues [active]
709986002056	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
709986002057	PEGA domain; Region: PEGA; pfam08308
709986002058	PEGA domain; Region: PEGA; pfam08308
709986002059	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
709986002060	Dynamin family; Region: Dynamin_N; pfam00350
709986002061	G1 box; other site
709986002062	GTP/Mg2+ binding site [chemical binding]; other site
709986002063	G2 box; other site
709986002064	Switch I region; other site
709986002065	G3 box; other site
709986002066	Switch II region; other site
709986002067	G4 box; other site
709986002068	G5 box; other site
709986002069	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
709986002070	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
709986002071	substrate binding pocket [chemical binding]; other site
709986002072	membrane-bound complex binding site; other site
709986002073	hinge residues; other site
709986002074	Major Facilitator Superfamily; Region: MFS_1; pfam07690
709986002075	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
709986002076	putative substrate translocation pore; other site
709986002077	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
709986002078	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
709986002079	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
709986002080	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
709986002081	active site residue [active]
709986002082	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
709986002083	active site residue [active]
709986002084	Fe-S metabolism associated domain; Region: SufE; cl00951
709986002085	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
709986002086	DinB family; Region: DinB; cl17821
709986002087	DinB superfamily; Region: DinB_2; pfam12867
709986002088	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
709986002089	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
709986002090	dimer interface [polypeptide binding]; other site
709986002091	substrate binding site [chemical binding]; other site
709986002092	metal binding site [ion binding]; metal-binding site
709986002093	Predicted integral membrane protein [Function unknown]; Region: COG5652
709986002094	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
709986002095	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
709986002096	Walker A/P-loop; other site
709986002097	ATP binding site [chemical binding]; other site
709986002098	Q-loop/lid; other site
709986002099	ABC transporter signature motif; other site
709986002100	Walker B; other site
709986002101	D-loop; other site
709986002102	H-loop/switch region; other site
709986002103	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
709986002104	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
709986002105	putative active site [active]
709986002106	substrate binding site [chemical binding]; other site
709986002107	putative cosubstrate binding site; other site
709986002108	catalytic site [active]
709986002109	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
709986002110	substrate binding site [chemical binding]; other site
709986002111	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
709986002112	active site
709986002113	catalytic residues [active]
709986002114	metal binding site [ion binding]; metal-binding site
709986002115	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
709986002116	Uncharacterized conserved protein [Function unknown]; Region: COG1624
709986002117	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
709986002118	AAA domain; Region: AAA_25; pfam13481
709986002119	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
709986002120	Roadblock/LC7 domain; Region: Robl_LC7; smart00960
709986002121	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
709986002122	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
709986002123	substrate-cofactor binding pocket; other site
709986002124	pyridoxal 5'-phosphate binding site [chemical binding]; other site
709986002125	catalytic residue [active]
709986002126	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
709986002127	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
709986002128	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
709986002129	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
709986002130	PQQ-like domain; Region: PQQ_2; pfam13360
709986002131	active site
709986002132	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
709986002133	Peptidases of the G1 family and homologs that might lack peptidase activity; Region: Peptidase_G1_like; cl03371
709986002134	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
709986002135	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
709986002136	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
709986002137	tetramer interface [polypeptide binding]; other site
709986002138	heme binding pocket [chemical binding]; other site
709986002139	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
709986002140	Transcriptional regulators [Transcription]; Region: MarR; COG1846
709986002141	MarR family; Region: MarR; pfam01047
709986002142	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
709986002143	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
709986002144	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
709986002145	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
709986002146	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
709986002147	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
709986002148	siderophore binding site; other site
709986002149	fumarate hydratase; Reviewed; Region: fumC; PRK00485
709986002150	Class II fumarases; Region: Fumarase_classII; cd01362
709986002151	active site
709986002152	tetramer interface [polypeptide binding]; other site
709986002153	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
709986002154	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
709986002155	NodB motif; other site
709986002156	active site
709986002157	catalytic site [active]
709986002158	metal binding site [ion binding]; metal-binding site
709986002159	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
709986002160	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
709986002161	DNA binding residues [nucleotide binding]
709986002162	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
709986002163	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
709986002164	amphipathic channel; other site
709986002165	Asn-Pro-Ala signature motifs; other site
709986002166	glycerol kinase; Provisional; Region: glpK; PRK00047
709986002167	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
709986002168	N- and C-terminal domain interface [polypeptide binding]; other site
709986002169	active site
709986002170	MgATP binding site [chemical binding]; other site
709986002171	catalytic site [active]
709986002172	metal binding site [ion binding]; metal-binding site
709986002173	glycerol binding site [chemical binding]; other site
709986002174	homotetramer interface [polypeptide binding]; other site
709986002175	homodimer interface [polypeptide binding]; other site
709986002176	FBP binding site [chemical binding]; other site
709986002177	protein IIAGlc interface [polypeptide binding]; other site
709986002178	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
709986002179	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
709986002180	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
709986002181	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
709986002182	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
709986002183	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
709986002184	metal ion-dependent adhesion site (MIDAS); other site
709986002185	MoxR-like ATPases [General function prediction only]; Region: COG0714
709986002186	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
709986002187	SWIM zinc finger; Region: SWIM; pfam04434
709986002188	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
709986002189	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
709986002190	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
709986002191	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
709986002192	DNA binding site [nucleotide binding]
709986002193	active site
709986002194	Uncharacterized conserved protein [Function unknown]; Region: COG0432
709986002195	Domain of unknown function (DUF4383); Region: DUF4383; pfam14325
709986002196	Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575
709986002197	active site
709986002198	dimer interface [polypeptide binding]; other site
709986002199	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
709986002200	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
709986002201	dimerization interface [polypeptide binding]; other site
709986002202	putative DNA binding site [nucleotide binding]; other site
709986002203	putative Zn2+ binding site [ion binding]; other site
709986002204	futalosine nucleosidase; Region: fut_nucase; TIGR03664
709986002205	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
709986002206	TPR motif; other site
709986002207	binding surface
709986002208	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
709986002209	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
709986002210	ATP binding site [chemical binding]; other site
709986002211	putative Mg++ binding site [ion binding]; other site
709986002212	nucleotide binding region [chemical binding]; other site
709986002213	helicase superfamily c-terminal domain; Region: HELICc; smart00490
709986002214	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
709986002215	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
709986002216	uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_1; cd10801
709986002217	putative active site [active]
709986002218	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
709986002219	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
709986002220	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
709986002221	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
709986002222	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
709986002223	trimer interface [polypeptide binding]; other site
709986002224	active site
709986002225	CoA binding site [chemical binding]; other site
709986002226	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
709986002227	glutaminyl-tRNA synthetase/YqeY domain fusion protein; Provisional; Region: PRK14703
709986002228	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
709986002229	active site
709986002230	HIGH motif; other site
709986002231	nucleotide binding site [chemical binding]; other site
709986002232	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
709986002233	KMSKS motif; other site
709986002234	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
709986002235	GatB domain; Region: GatB_Yqey; smart00845
709986002236	Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563
709986002237	active site triad [active]
709986002238	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
709986002239	Coenzyme A binding pocket [chemical binding]; other site
709986002240	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
709986002241	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
709986002242	dimer interface [polypeptide binding]; other site
709986002243	active site
709986002244	metal binding site [ion binding]; metal-binding site
709986002245	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
709986002246	Coenzyme A binding pocket [chemical binding]; other site
709986002247	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
709986002248	Coenzyme A binding pocket [chemical binding]; other site
709986002249	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
709986002250	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
709986002251	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
709986002252	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
709986002253	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
709986002254	DNA binding residues [nucleotide binding]
709986002255	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
709986002256	active site
709986002257	substrate binding site [chemical binding]; other site
709986002258	Phosphotransferase enzyme family; Region: APH; pfam01636
709986002259	ATP binding site [chemical binding]; other site
709986002260	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
709986002261	active site
709986002262	catalytic residues [active]
709986002263	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
709986002264	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
709986002265	metal binding site [ion binding]; metal-binding site
709986002266	Predicted integral membrane protein [Function unknown]; Region: COG5637
709986002267	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
709986002268	putative hydrophobic ligand binding site [chemical binding]; other site
709986002269	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
709986002270	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
709986002271	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
709986002272	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986002273	dimer interface [polypeptide binding]; other site
709986002274	conserved gate region; other site
709986002275	putative PBP binding loops; other site
709986002276	ABC-ATPase subunit interface; other site
709986002277	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
709986002278	Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720
709986002279	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
709986002280	VanW like protein; Region: VanW; pfam04294
709986002281	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
709986002282	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
709986002283	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
709986002284	nucleotide binding site [chemical binding]; other site
709986002285	N-acetyl-L-glutamate binding site [chemical binding]; other site
709986002286	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
709986002287	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
709986002288	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
709986002289	FMN binding site [chemical binding]; other site
709986002290	active site
709986002291	catalytic residues [active]
709986002292	substrate binding site [chemical binding]; other site
709986002293	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
709986002294	active site
709986002295	NTP binding site [chemical binding]; other site
709986002296	metal binding triad [ion binding]; metal-binding site
709986002297	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
709986002298	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
709986002299	putative active site [active]
709986002300	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
709986002301	Chromate transporter; Region: Chromate_transp; pfam02417
709986002302	TPR repeat; Region: TPR_11; pfam13414
709986002303	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
709986002304	binding surface
709986002305	TPR motif; other site
709986002306	Transcriptional regulator [Transcription]; Region: LytR; COG1316
709986002307	putative acetyltransferase; Provisional; Region: PRK03624
709986002308	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
709986002309	Coenzyme A binding pocket [chemical binding]; other site
709986002310	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
709986002311	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
709986002312	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
709986002313	Coenzyme A binding pocket [chemical binding]; other site
709986002314	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
709986002315	Coenzyme A binding pocket [chemical binding]; other site
709986002316	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
709986002317	Coenzyme A binding pocket [chemical binding]; other site
709986002318	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
709986002319	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
709986002320	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
709986002321	Walker A/P-loop; other site
709986002322	ATP binding site [chemical binding]; other site
709986002323	Q-loop/lid; other site
709986002324	ABC transporter signature motif; other site
709986002325	Walker B; other site
709986002326	D-loop; other site
709986002327	H-loop/switch region; other site
709986002328	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
709986002329	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
709986002330	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
709986002331	dsRNA binding site [nucleotide binding]; other site
709986002332	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
709986002333	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
709986002334	motif II; other site
709986002335	hypothetical protein; Reviewed; Region: PRK12497
709986002336	Protein of unknown function (DUF461); Region: DUF461; pfam04314
709986002337	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
709986002338	trimer interface [polypeptide binding]; other site
709986002339	active site
709986002340	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
709986002341	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
709986002342	active site
709986002343	metal binding site [ion binding]; metal-binding site
709986002344	GTPase Era; Reviewed; Region: era; PRK00089
709986002345	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
709986002346	G1 box; other site
709986002347	GTP/Mg2+ binding site [chemical binding]; other site
709986002348	Switch I region; other site
709986002349	G2 box; other site
709986002350	Switch II region; other site
709986002351	G3 box; other site
709986002352	G4 box; other site
709986002353	G5 box; other site
709986002354	KH domain; Region: KH_2; pfam07650
709986002355	sugar efflux transporter B; Provisional; Region: PRK15011
709986002356	Thymidine phosphorylase [Nucleotide transport and metabolism]; Region: DeoA; COG0213
709986002357	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
709986002358	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
709986002359	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
709986002360	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
709986002361	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
709986002362	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
709986002363	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
709986002364	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
709986002365	FMN binding site [chemical binding]; other site
709986002366	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
709986002367	dimer interface [polypeptide binding]; other site
709986002368	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
709986002369	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
709986002370	active site
709986002371	catalytic tetrad [active]
709986002372	FRG domain; Region: FRG; pfam08867
709986002373	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
709986002374	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
709986002375	catalytic residues [active]
709986002376	catalytic nucleophile [active]
709986002377	Recombinase; Region: Recombinase; pfam07508
709986002378	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
709986002379	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
709986002380	active site
709986002381	DNA binding site [nucleotide binding]
709986002382	Int/Topo IB signature motif; other site
709986002383	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
709986002384	Helix-hairpin-helix motif; Region: HHH; pfam00633
709986002385	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
709986002386	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
709986002387	Competence protein; Region: Competence; pfam03772
709986002388	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
709986002389	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
709986002390	dimer interface [polypeptide binding]; other site
709986002391	FMN binding site [chemical binding]; other site
709986002392	NADPH bind site [chemical binding]; other site
709986002393	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
709986002394	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
709986002395	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
709986002396	FeS/SAM binding site; other site
709986002397	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
709986002398	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
709986002399	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
709986002400	lipoyl synthase; Provisional; Region: PRK05481
709986002401	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
709986002402	FeS/SAM binding site; other site
709986002403	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
709986002404	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
709986002405	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
709986002406	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
709986002407	putative active site [active]
709986002408	catalytic site [active]
709986002409	putative metal binding site [ion binding]; other site
709986002410	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
709986002411	Protein of unknown function (DUF1003); Region: DUF1003; cl01831
709986002412	malate dehydrogenase; Provisional; Region: PRK05442
709986002413	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
709986002414	NAD(P) binding site [chemical binding]; other site
709986002415	dimer interface [polypeptide binding]; other site
709986002416	malate binding site [chemical binding]; other site
709986002417	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
709986002418	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
709986002419	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
709986002420	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
709986002421	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
709986002422	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
709986002423	EamA-like transporter family; Region: EamA; pfam00892
709986002424	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
709986002425	EamA-like transporter family; Region: EamA; pfam00892
709986002426	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
709986002427	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
709986002428	Walker A/P-loop; other site
709986002429	ATP binding site [chemical binding]; other site
709986002430	Q-loop/lid; other site
709986002431	ABC transporter signature motif; other site
709986002432	Walker B; other site
709986002433	D-loop; other site
709986002434	H-loop/switch region; other site
709986002435	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
709986002436	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986002437	dimer interface [polypeptide binding]; other site
709986002438	conserved gate region; other site
709986002439	putative PBP binding loops; other site
709986002440	ABC-ATPase subunit interface; other site
709986002441	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
709986002442	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
709986002443	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
709986002444	inhibitor-cofactor binding pocket; inhibition site
709986002445	pyridoxal 5'-phosphate binding site [chemical binding]; other site
709986002446	catalytic residue [active]
709986002447	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
709986002448	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
709986002449	Walker A motif; other site
709986002450	ATP binding site [chemical binding]; other site
709986002451	Walker B motif; other site
709986002452	DNA polymerase III subunit delta'; Validated; Region: PRK08485
709986002453	ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470
709986002454	arginine finger; other site
709986002455	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
709986002456	PEGA domain; Region: PEGA; pfam08308
709986002457	PRC-barrel domain; Region: PRC; pfam05239
709986002458	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861
709986002459	Domain of unknown function (DUF305); Region: DUF305; pfam03713
709986002460	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
709986002461	Coenzyme A binding pocket [chemical binding]; other site
709986002462	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
709986002463	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
709986002464	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
709986002465	trmE is a tRNA modification GTPase; Region: trmE; cd04164
709986002466	G1 box; other site
709986002467	GTP/Mg2+ binding site [chemical binding]; other site
709986002468	Switch I region; other site
709986002469	G2 box; other site
709986002470	Switch II region; other site
709986002471	G3 box; other site
709986002472	G4 box; other site
709986002473	G5 box; other site
709986002474	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
709986002475	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
709986002476	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
709986002477	Integral membrane protein DUF95; Region: DUF95; pfam01944
709986002478	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
709986002479	Coenzyme A binding pocket [chemical binding]; other site
709986002480	Domain of unknown function (DUF4032); Region: DUF4032; pfam13224
709986002481	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
709986002482	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
709986002483	Moco binding site; other site
709986002484	metal coordination site [ion binding]; other site
709986002485	CAAX protease self-immunity; Region: Abi; pfam02517
709986002486	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
709986002487	active site
709986002488	dimer interface [polypeptide binding]; other site
709986002489	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
709986002490	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
709986002491	EDD domain protein, DegV family; Region: DegV; TIGR00762
709986002492	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
709986002493	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
709986002494	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
709986002495	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
709986002496	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
709986002497	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
709986002498	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
709986002499	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
709986002500	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
709986002501	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
709986002502	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
709986002503	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
709986002504	DNA binding site [nucleotide binding]
709986002505	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
709986002506	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
709986002507	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
709986002508	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
709986002509	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
709986002510	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
709986002511	RPB10 interaction site [polypeptide binding]; other site
709986002512	RPB1 interaction site [polypeptide binding]; other site
709986002513	RPB11 interaction site [polypeptide binding]; other site
709986002514	RPB3 interaction site [polypeptide binding]; other site
709986002515	RPB12 interaction site [polypeptide binding]; other site
709986002516	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
709986002517	peripheral dimer interface [polypeptide binding]; other site
709986002518	core dimer interface [polypeptide binding]; other site
709986002519	L10 interface [polypeptide binding]; other site
709986002520	L11 interface [polypeptide binding]; other site
709986002521	putative EF-Tu interaction site [polypeptide binding]; other site
709986002522	putative EF-G interaction site [polypeptide binding]; other site
709986002523	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
709986002524	23S rRNA interface [nucleotide binding]; other site
709986002525	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
709986002526	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
709986002527	mRNA/rRNA interface [nucleotide binding]; other site
709986002528	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
709986002529	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
709986002530	23S rRNA interface [nucleotide binding]; other site
709986002531	L7/L12 interface [polypeptide binding]; other site
709986002532	putative thiostrepton binding site; other site
709986002533	L25 interface [polypeptide binding]; other site
709986002534	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
709986002535	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
709986002536	putative homodimer interface [polypeptide binding]; other site
709986002537	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
709986002538	heterodimer interface [polypeptide binding]; other site
709986002539	homodimer interface [polypeptide binding]; other site
709986002540	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
709986002541	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
709986002542	elongation factor Tu; Reviewed; Region: PRK00049
709986002543	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
709986002544	G1 box; other site
709986002545	GEF interaction site [polypeptide binding]; other site
709986002546	GTP/Mg2+ binding site [chemical binding]; other site
709986002547	Switch I region; other site
709986002548	G2 box; other site
709986002549	G3 box; other site
709986002550	Switch II region; other site
709986002551	G4 box; other site
709986002552	G5 box; other site
709986002553	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
709986002554	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
709986002555	Antibiotic Binding Site [chemical binding]; other site
709986002556	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
709986002557	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
709986002558	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
709986002559	Walker A/P-loop; other site
709986002560	ATP binding site [chemical binding]; other site
709986002561	Q-loop/lid; other site
709986002562	ABC transporter signature motif; other site
709986002563	Walker B; other site
709986002564	D-loop; other site
709986002565	H-loop/switch region; other site
709986002566	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
709986002567	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
709986002568	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
709986002569	Walker A/P-loop; other site
709986002570	ATP binding site [chemical binding]; other site
709986002571	Q-loop/lid; other site
709986002572	ABC transporter signature motif; other site
709986002573	Walker B; other site
709986002574	D-loop; other site
709986002575	H-loop/switch region; other site
709986002576	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
709986002577	Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018
709986002578	recombination protein RecR; Reviewed; Region: recR; PRK00076
709986002579	RecR protein; Region: RecR; pfam02132
709986002580	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
709986002581	putative active site [active]
709986002582	putative metal-binding site [ion binding]; other site
709986002583	tetramer interface [polypeptide binding]; other site
709986002584	hypothetical protein; Validated; Region: PRK00153
709986002585	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
709986002586	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
709986002587	Zn2+ binding site [ion binding]; other site
709986002588	Mg2+ binding site [ion binding]; other site
709986002589	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
709986002590	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
709986002591	additional DNA contacts [nucleotide binding]; other site
709986002592	mismatch recognition site; other site
709986002593	active site
709986002594	zinc binding site [ion binding]; other site
709986002595	DNA intercalation site [nucleotide binding]; other site
709986002596	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
709986002597	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
709986002598	cofactor binding site; other site
709986002599	DNA binding site [nucleotide binding]
709986002600	substrate interaction site [chemical binding]; other site
709986002601	Restriction endonuclease NaeI; Region: NaeI; pfam09126
709986002602	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
709986002603	nucleotide binding site [chemical binding]; other site
709986002604	DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358
709986002605	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
709986002606	active site
709986002607	metal binding site [ion binding]; metal-binding site
709986002608	phage replicative helicase, DnaB family, HK022 subfamily; Region: phage_DnaB; TIGR03600
709986002609	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
709986002610	Walker A motif; other site
709986002611	ATP binding site [chemical binding]; other site
709986002612	Walker B motif; other site
709986002613	Helix-turn-helix domain; Region: HTH_36; pfam13730
709986002614	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
709986002615	Int/Topo IB signature motif; other site
709986002616	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
709986002617	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
709986002618	putative active site [active]
709986002619	catalytic site [active]
709986002620	putative metal binding site [ion binding]; other site
709986002621	Predicted acetyltransferase [General function prediction only]; Region: COG2388
709986002622	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
709986002623	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
709986002624	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
709986002625	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
709986002626	active site
709986002627	dimer interface [polypeptide binding]; other site
709986002628	motif 1; other site
709986002629	motif 2; other site
709986002630	motif 3; other site
709986002631	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
709986002632	anticodon binding site; other site
709986002633	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
709986002634	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
709986002635	putative active site [active]
709986002636	putative metal binding site [ion binding]; other site
709986002637	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
709986002638	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
709986002639	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
709986002640	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986002641	dimer interface [polypeptide binding]; other site
709986002642	conserved gate region; other site
709986002643	putative PBP binding loops; other site
709986002644	ABC-ATPase subunit interface; other site
709986002645	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986002646	dimer interface [polypeptide binding]; other site
709986002647	conserved gate region; other site
709986002648	putative PBP binding loops; other site
709986002649	ABC-ATPase subunit interface; other site
709986002650	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
709986002651	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
709986002652	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
709986002653	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
709986002654	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
709986002655	putative active site [active]
709986002656	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
709986002657	Glyco_18 domain; Region: Glyco_18; smart00636
709986002658	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
709986002659	active site
709986002660	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986002661	PAS domain; Region: PAS_9; pfam13426
709986002662	putative active site [active]
709986002663	heme pocket [chemical binding]; other site
709986002664	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
709986002665	GAF domain; Region: GAF; pfam01590
709986002666	PAS domain S-box; Region: sensory_box; TIGR00229
709986002667	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986002668	putative active site [active]
709986002669	heme pocket [chemical binding]; other site
709986002670	GAF domain; Region: GAF_3; pfam13492
709986002671	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
709986002672	PAS domain S-box; Region: sensory_box; TIGR00229
709986002673	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986002674	putative active site [active]
709986002675	heme pocket [chemical binding]; other site
709986002676	PAS domain S-box; Region: sensory_box; TIGR00229
709986002677	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986002678	putative active site [active]
709986002679	heme pocket [chemical binding]; other site
709986002680	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
709986002681	GAF domain; Region: GAF_3; pfam13492
709986002682	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986002683	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986002684	metal binding site [ion binding]; metal-binding site
709986002685	active site
709986002686	I-site; other site
709986002687	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
709986002688	putative active site [active]
709986002689	putative metal binding site [ion binding]; other site
709986002690	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
709986002691	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
709986002692	active site
709986002693	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
709986002694	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
709986002695	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
709986002696	active site
709986002697	bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379
709986002698	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional proteins, also containing a Nudix hydrolase domain; Region: NMNAT_Nudix; cd02168
709986002699	active site
709986002700	(T/H)XGH motif; other site
709986002701	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
709986002702	nudix motif; other site
709986002703	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
709986002704	putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198
709986002705	pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569
709986002706	active site
709986002707	nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526
709986002708	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
709986002709	active site
709986002710	nucleotide binding site [chemical binding]; other site
709986002711	HIGH motif; other site
709986002712	KMSKS motif; other site
709986002713	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
709986002714	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
709986002715	Coenzyme A binding pocket [chemical binding]; other site
709986002716	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
709986002717	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
709986002718	Walker A/P-loop; other site
709986002719	ATP binding site [chemical binding]; other site
709986002720	Q-loop/lid; other site
709986002721	ABC transporter signature motif; other site
709986002722	Walker B; other site
709986002723	D-loop; other site
709986002724	H-loop/switch region; other site
709986002725	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
709986002726	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986002727	dimer interface [polypeptide binding]; other site
709986002728	conserved gate region; other site
709986002729	putative PBP binding loops; other site
709986002730	ABC-ATPase subunit interface; other site
709986002731	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
709986002732	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
709986002733	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
709986002734	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
709986002735	active site
709986002736	8-oxo-dGMP binding site [chemical binding]; other site
709986002737	nudix motif; other site
709986002738	metal binding site [ion binding]; metal-binding site
709986002739	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
709986002740	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
709986002741	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
709986002742	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
709986002743	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
709986002744	catalytic residues [active]
709986002745	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
709986002746	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
709986002747	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
709986002748	putative active site [active]
709986002749	putative substrate binding site [chemical binding]; other site
709986002750	putative cosubstrate binding site; other site
709986002751	catalytic site [active]
709986002752	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
709986002753	amphipathic channel; other site
709986002754	Asn-Pro-Ala signature motifs; other site
709986002755	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
709986002756	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
709986002757	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
709986002758	dimerization interface [polypeptide binding]; other site
709986002759	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
709986002760	dimer interface [polypeptide binding]; other site
709986002761	phosphorylation site [posttranslational modification]
709986002762	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986002763	ATP binding site [chemical binding]; other site
709986002764	Mg2+ binding site [ion binding]; other site
709986002765	G-X-G motif; other site
709986002766	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
709986002767	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986002768	active site
709986002769	phosphorylation site [posttranslational modification]
709986002770	intermolecular recognition site; other site
709986002771	dimerization interface [polypeptide binding]; other site
709986002772	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
709986002773	DNA binding site [nucleotide binding]
709986002774	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
709986002775	HlyD family secretion protein; Region: HlyD_3; pfam13437
709986002776	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
709986002777	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
709986002778	Walker A/P-loop; other site
709986002779	ATP binding site [chemical binding]; other site
709986002780	Q-loop/lid; other site
709986002781	ABC transporter signature motif; other site
709986002782	Walker B; other site
709986002783	D-loop; other site
709986002784	H-loop/switch region; other site
709986002785	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
709986002786	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
709986002787	FtsX-like permease family; Region: FtsX; pfam02687
709986002788	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
709986002789	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
709986002790	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
709986002791	3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356
709986002792	hinge; other site
709986002793	active site
709986002794	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
709986002795	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
709986002796	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
709986002797	Major Facilitator Superfamily; Region: MFS_1; pfam07690
709986002798	putative substrate translocation pore; other site
709986002799	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
709986002800	MarR family; Region: MarR_2; cl17246
709986002801	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
709986002802	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
709986002803	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
709986002804	dimer interface [polypeptide binding]; other site
709986002805	active site
709986002806	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
709986002807	catalytic residues [active]
709986002808	substrate binding site [chemical binding]; other site
709986002809	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
709986002810	AAA domain; Region: AAA_33; pfam13671
709986002811	ATP-binding site [chemical binding]; other site
709986002812	Gluconate-6-phosphate binding site [chemical binding]; other site
709986002813	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
709986002814	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
709986002815	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
709986002816	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
709986002817	classical (c) SDRs; Region: SDR_c; cd05233
709986002818	NAD(P) binding site [chemical binding]; other site
709986002819	active site
709986002820	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
709986002821	elongation factor G; Reviewed; Region: PRK12740
709986002822	G1 box; other site
709986002823	putative GEF interaction site [polypeptide binding]; other site
709986002824	GTP/Mg2+ binding site [chemical binding]; other site
709986002825	Switch I region; other site
709986002826	G2 box; other site
709986002827	G3 box; other site
709986002828	Switch II region; other site
709986002829	G4 box; other site
709986002830	G5 box; other site
709986002831	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
709986002832	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
709986002833	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
709986002834	AAA domain; Region: AAA_18; pfam13238
709986002835	AAA domain; Region: AAA_17; pfam13207
709986002836	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
709986002837	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
709986002838	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
709986002839	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
709986002840	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
709986002841	Phosphotransferase enzyme family; Region: APH; pfam01636
709986002842	Ecdysteroid kinase; Region: EcKinase; cl17738
709986002843	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
709986002844	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
709986002845	homotetramer interface [polypeptide binding]; other site
709986002846	FMN binding site [chemical binding]; other site
709986002847	homodimer contacts [polypeptide binding]; other site
709986002848	putative active site [active]
709986002849	putative substrate binding site [chemical binding]; other site
709986002850	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
709986002851	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
709986002852	metal ion-dependent adhesion site (MIDAS); other site
709986002853	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
709986002854	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
709986002855	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
709986002856	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
709986002857	RNase E interface [polypeptide binding]; other site
709986002858	trimer interface [polypeptide binding]; other site
709986002859	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
709986002860	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
709986002861	RNase E interface [polypeptide binding]; other site
709986002862	trimer interface [polypeptide binding]; other site
709986002863	active site
709986002864	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
709986002865	putative nucleic acid binding region [nucleotide binding]; other site
709986002866	G-X-X-G motif; other site
709986002867	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
709986002868	RNA binding site [nucleotide binding]; other site
709986002869	domain interface; other site
709986002870	amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924
709986002871	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
709986002872	putative substrate translocation pore; other site
709986002873	POT family; Region: PTR2; cl17359
709986002874	acyl-CoA binding pocket [chemical binding]; other site
709986002875	Acyl CoA binding protein; Region: ACBP; pfam00887
709986002876	CoA binding site [chemical binding]; other site
709986002877	Domain of unknown function (DUF955); Region: DUF955; cl01076
709986002878	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
709986002879	dihydropteroate synthase; Region: DHPS; TIGR01496
709986002880	substrate binding pocket [chemical binding]; other site
709986002881	dimer interface [polypeptide binding]; other site
709986002882	inhibitor binding site; inhibition site
709986002883	Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539
709986002884	active site
709986002885	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
709986002886	catalytic center binding site [active]
709986002887	ATP binding site [chemical binding]; other site
709986002888	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
709986002889	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
709986002890	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
709986002891	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
709986002892	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
709986002893	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
709986002894	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
709986002895	catalytic residue [active]
709986002896	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986002897	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986002898	metal binding site [ion binding]; metal-binding site
709986002899	active site
709986002900	I-site; other site
709986002901	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
709986002902	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
709986002903	ATP-grasp domain; Region: ATP-grasp_4; cl17255
709986002904	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
709986002905	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
709986002906	ATP-grasp domain; Region: ATP-grasp_4; cl17255
709986002907	argininosuccinate synthase; Provisional; Region: PRK13820
709986002908	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
709986002909	ANP binding site [chemical binding]; other site
709986002910	Substrate Binding Site II [chemical binding]; other site
709986002911	Substrate Binding Site I [chemical binding]; other site
709986002912	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
709986002913	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
709986002914	Coenzyme A binding pocket [chemical binding]; other site
709986002915	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
709986002916	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
709986002917	Coenzyme A binding pocket [chemical binding]; other site
709986002918	argininosuccinate lyase; Provisional; Region: PRK00855
709986002919	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
709986002920	active sites [active]
709986002921	tetramer interface [polypeptide binding]; other site
709986002922	putative acetyltransferase; Provisional; Region: PRK03624
709986002923	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
709986002924	Coenzyme A binding pocket [chemical binding]; other site
709986002925	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
709986002926	Coenzyme A binding pocket [chemical binding]; other site
709986002927	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
709986002928	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
709986002929	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
709986002930	catalytic site [active]
709986002931	subunit interface [polypeptide binding]; other site
709986002932	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719
709986002933	Domain of unknown function DUF11; Region: DUF11; pfam01345
709986002934	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
709986002935	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
709986002936	Domain of unknown function DUF11; Region: DUF11; cl17728
709986002937	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
709986002938	Domain of unknown function DUF11; Region: DUF11; pfam01345
709986002939	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
709986002940	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
709986002941	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
709986002942	Found in ATP-dependent protease La (LON); Region: LON; smart00464
709986002943	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
709986002944	Walker A motif; other site
709986002945	ATP binding site [chemical binding]; other site
709986002946	Walker B motif; other site
709986002947	arginine finger; other site
709986002948	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
709986002949	Uncharacterized ACR, COG1678; Region: DUF179; cl00731
709986002950	PAS domain; Region: PAS; smart00091
709986002951	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986002952	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986002953	metal binding site [ion binding]; metal-binding site
709986002954	active site
709986002955	I-site; other site
709986002956	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
709986002957	DNA primase; Validated; Region: dnaG; PRK05667
709986002958	CHC2 zinc finger; Region: zf-CHC2; pfam01807
709986002959	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
709986002960	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
709986002961	active site
709986002962	metal binding site [ion binding]; metal-binding site
709986002963	interdomain interaction site; other site
709986002964	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
709986002965	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
709986002966	Walker A motif; other site
709986002967	ATP binding site [chemical binding]; other site
709986002968	Walker B motif; other site
709986002969	arginine finger; other site
709986002970	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
709986002971	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
709986002972	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
709986002973	Cu(I) binding site [ion binding]; other site
709986002974	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
709986002975	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
709986002976	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
709986002977	Subunit I/III interface [polypeptide binding]; other site
709986002978	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
709986002979	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
709986002980	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
709986002981	Cytochrome c; Region: Cytochrom_C; pfam00034
709986002982	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
709986002983	UbiA prenyltransferase family; Region: UbiA; pfam01040
709986002984	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
709986002985	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
709986002986	Protein of unknown function (DUF420); Region: DUF420; cl00989
709986002987	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
709986002988	oligomerization interface [polypeptide binding]; other site
709986002989	active site
709986002990	metal binding site [ion binding]; metal-binding site
709986002991	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
709986002992	TPR motif; other site
709986002993	TPR repeat; Region: TPR_11; pfam13414
709986002994	binding surface
709986002995	FtsH Extracellular; Region: FtsH_ext; pfam06480
709986002996	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
709986002997	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
709986002998	Walker A motif; other site
709986002999	ATP binding site [chemical binding]; other site
709986003000	Walker B motif; other site
709986003001	arginine finger; other site
709986003002	Peptidase family M41; Region: Peptidase_M41; pfam01434
709986003003	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
709986003004	Coenzyme A binding pocket [chemical binding]; other site
709986003005	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
709986003006	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
709986003007	Switch I; other site
709986003008	Switch II; other site
709986003009	cell division topological specificity factor MinE; Region: minE; TIGR01215
709986003010	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
709986003011	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
709986003012	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
709986003013	Walker A/P-loop; other site
709986003014	ATP binding site [chemical binding]; other site
709986003015	Q-loop/lid; other site
709986003016	ABC transporter signature motif; other site
709986003017	Walker B; other site
709986003018	D-loop; other site
709986003019	H-loop/switch region; other site
709986003020	potential frameshift: common BLAST hit: gi|94985893|ref|YP_605257.1| transglutaminase-like protein
709986003021	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
709986003022	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
709986003023	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
709986003024	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
709986003025	Protein of unknown function DUF58; Region: DUF58; pfam01882
709986003026	MoxR-like ATPases [General function prediction only]; Region: COG0714
709986003027	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
709986003028	Walker A motif; other site
709986003029	ATP binding site [chemical binding]; other site
709986003030	Walker B motif; other site
709986003031	arginine finger; other site
709986003032	Peptidase family M23; Region: Peptidase_M23; pfam01551
709986003033	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
709986003034	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
709986003035	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
709986003036	DNA binding residues [nucleotide binding]
709986003037	dimerization interface [polypeptide binding]; other site
709986003038	H+ Antiporter protein; Region: 2A0121; TIGR00900
709986003039	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
709986003040	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
709986003041	AsnC family; Region: AsnC_trans_reg; pfam01037
709986003042	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
709986003043	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
709986003044	metal binding site [ion binding]; metal-binding site
709986003045	dimer interface [polypeptide binding]; other site
709986003046	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
709986003047	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
709986003048	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
709986003049	Ligand Binding Site [chemical binding]; other site
709986003050	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
709986003051	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
709986003052	putative cation:proton antiport protein; Provisional; Region: PRK10669
709986003053	TrkA-N domain; Region: TrkA_N; pfam02254
709986003054	Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148
709986003055	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
709986003056	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
709986003057	E3 interaction surface; other site
709986003058	lipoyl attachment site [posttranslational modification]; other site
709986003059	e3 binding domain; Region: E3_binding; pfam02817
709986003060	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
709986003061	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
709986003062	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
709986003063	dimer interface [polypeptide binding]; other site
709986003064	TPP-binding site [chemical binding]; other site
709986003065	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
709986003066	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
709986003067	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
709986003068	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
709986003069	dimerization interface [polypeptide binding]; other site
709986003070	substrate binding pocket [chemical binding]; other site
709986003071	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
709986003072	intracellular protease, PfpI family; Region: PfpI; TIGR01382
709986003073	proposed catalytic triad [active]
709986003074	conserved cys residue [active]
709986003075	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
709986003076	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
709986003077	NAD(P) binding site [chemical binding]; other site
709986003078	Cupin domain; Region: Cupin_2; pfam07883
709986003079	glycine dehydrogenase; Provisional; Region: PRK05367
709986003080	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
709986003081	tetramer interface [polypeptide binding]; other site
709986003082	pyridoxal 5'-phosphate binding site [chemical binding]; other site
709986003083	catalytic residue [active]
709986003084	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
709986003085	tetramer interface [polypeptide binding]; other site
709986003086	pyridoxal 5'-phosphate binding site [chemical binding]; other site
709986003087	catalytic residue [active]
709986003088	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
709986003089	lipoyl attachment site [posttranslational modification]; other site
709986003090	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
709986003091	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
709986003092	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
709986003093	Transglycosylase; Region: Transgly; pfam00912
709986003094	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
709986003095	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
709986003096	superoxide dismutase; Provisional; Region: PRK10925
709986003097	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
709986003098	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
709986003099	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
709986003100	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
709986003101	RNA binding surface [nucleotide binding]; other site
709986003102	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
709986003103	active site
709986003104	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
709986003105	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
709986003106	dimerization interface [polypeptide binding]; other site
709986003107	domain crossover interface; other site
709986003108	redox-dependent activation switch; other site
709986003109	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
709986003110	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
709986003111	GTP binding site; other site
709986003112	Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134
709986003113	NAD(P) binding site [chemical binding]; other site
709986003114	catalytic residues [active]
709986003115	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
709986003116	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
709986003117	S-adenosylmethionine binding site [chemical binding]; other site
709986003118	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
709986003119	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
709986003120	active site
709986003121	(T/H)XGH motif; other site
709986003122	Tetratricopeptide repeat; Region: TPR_12; pfam13424
709986003123	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
709986003124	catalytic residues [active]
709986003125	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782
709986003126	active site
709986003127	RNA/DNA hybrid binding site [nucleotide binding]; other site
709986003128	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
709986003129	Thiamine pyrophosphokinase; Region: TPK; cd07995
709986003130	active site
709986003131	dimerization interface [polypeptide binding]; other site
709986003132	thiamine binding site [chemical binding]; other site
709986003133	PAS domain; Region: PAS_9; pfam13426
709986003134	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
709986003135	GAF domain; Region: GAF_3; pfam13492
709986003136	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
709986003137	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
709986003138	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986003139	putative active site [active]
709986003140	PAS fold; Region: PAS_3; pfam08447
709986003141	heme pocket [chemical binding]; other site
709986003142	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
709986003143	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
709986003144	dimer interface [polypeptide binding]; other site
709986003145	phosphorylation site [posttranslational modification]
709986003146	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986003147	ATP binding site [chemical binding]; other site
709986003148	Mg2+ binding site [ion binding]; other site
709986003149	G-X-G motif; other site
709986003150	FRG domain; Region: FRG; pfam08867
709986003151	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
709986003152	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
709986003153	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
709986003154	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
709986003155	Coenzyme A binding pocket [chemical binding]; other site
709986003156	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
709986003157	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
709986003158	putative active site; other site
709986003159	catalytic triad [active]
709986003160	putative dimer interface [polypeptide binding]; other site
709986003161	CHASE4 domain; Region: CHASE4; pfam05228
709986003162	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986003163	metal binding site [ion binding]; metal-binding site
709986003164	active site
709986003165	I-site; other site
709986003166	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
709986003167	Methyltransferase domain; Region: Methyltransf_23; pfam13489
709986003168	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
709986003169	S-adenosylmethionine binding site [chemical binding]; other site
709986003170	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
709986003171	active site
709986003172	Peptidase family M48; Region: Peptidase_M48; cl12018
709986003173	recombination factor protein RarA; Reviewed; Region: PRK13342
709986003174	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
709986003175	Walker A motif; other site
709986003176	ATP binding site [chemical binding]; other site
709986003177	Walker B motif; other site
709986003178	arginine finger; other site
709986003179	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
709986003180	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14323
709986003181	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
709986003182	active site
709986003183	substrate binding site [chemical binding]; other site
709986003184	metal binding site [ion binding]; metal-binding site
709986003185	Ribosome-binding factor A; Region: RBFA; pfam02033
709986003186	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
709986003187	active site
709986003188	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
709986003189	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
709986003190	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
709986003191	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
709986003192	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986003193	dimer interface [polypeptide binding]; other site
709986003194	conserved gate region; other site
709986003195	ABC-ATPase subunit interface; other site
709986003196	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
709986003197	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
709986003198	Walker A/P-loop; other site
709986003199	ATP binding site [chemical binding]; other site
709986003200	Q-loop/lid; other site
709986003201	ABC transporter signature motif; other site
709986003202	Walker B; other site
709986003203	D-loop; other site
709986003204	H-loop/switch region; other site
709986003205	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986003206	ABC-ATPase subunit interface; other site
709986003207	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
709986003208	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
709986003209	IHF - DNA interface [nucleotide binding]; other site
709986003210	IHF dimer interface [polypeptide binding]; other site
709986003211	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
709986003212	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
709986003213	ATP binding site [chemical binding]; other site
709986003214	substrate interface [chemical binding]; other site
709986003215	membrane protein; Provisional; Region: PRK14401
709986003216	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
709986003217	binding surface
709986003218	TPR motif; other site
709986003219	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
709986003220	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14612
709986003221	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
709986003222	substrate binding site; other site
709986003223	dimer interface; other site
709986003224	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
709986003225	Flavoprotein; Region: Flavoprotein; pfam02441
709986003226	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
709986003227	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986003228	active site
709986003229	phosphorylation site [posttranslational modification]
709986003230	intermolecular recognition site; other site
709986003231	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
709986003232	DNA binding residues [nucleotide binding]
709986003233	dimerization interface [polypeptide binding]; other site
709986003234	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
709986003235	Histidine kinase; Region: HisKA_3; pfam07730
709986003236	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986003237	ATP binding site [chemical binding]; other site
709986003238	Mg2+ binding site [ion binding]; other site
709986003239	G-X-G motif; other site
709986003240	ABC-2 type transporter; Region: ABC2_membrane; cl17235
709986003241	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
709986003242	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
709986003243	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
709986003244	Walker A/P-loop; other site
709986003245	ATP binding site [chemical binding]; other site
709986003246	Q-loop/lid; other site
709986003247	ABC transporter signature motif; other site
709986003248	Walker B; other site
709986003249	D-loop; other site
709986003250	H-loop/switch region; other site
709986003251	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
709986003252	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
709986003253	active site
709986003254	metal binding site [ion binding]; metal-binding site
709986003255	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
709986003256	Ribonuclease P; Region: Ribonuclease_P; pfam00825
709986003257	Haemolytic domain; Region: Haemolytic; pfam01809
709986003258	membrane protein insertase; Provisional; Region: PRK01318
709986003259	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
709986003260	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
709986003261	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
709986003262	G-X-X-G motif; other site
709986003263	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
709986003264	RxxxH motif; other site
709986003265	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
709986003266	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
709986003267	Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328
709986003268	Transglycosylase; Region: Transgly; pfam00912
709986003269	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
709986003270	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
709986003271	Response regulator receiver domain; Region: Response_reg; pfam00072
709986003272	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986003273	active site
709986003274	phosphorylation site [posttranslational modification]
709986003275	intermolecular recognition site; other site
709986003276	dimerization interface [polypeptide binding]; other site
709986003277	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710
709986003278	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
709986003279	acyl-activating enzyme (AAE) consensus motif; other site
709986003280	putative AMP binding site [chemical binding]; other site
709986003281	putative active site [active]
709986003282	putative CoA binding site [chemical binding]; other site
709986003283	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
709986003284	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266
709986003285	putative NAD(P) binding site [chemical binding]; other site
709986003286	structural Zn binding site [ion binding]; other site
709986003287	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
709986003288	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
709986003289	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
709986003290	NodB motif; other site
709986003291	active site
709986003292	catalytic site [active]
709986003293	metal binding site [ion binding]; metal-binding site
709986003294	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
709986003295	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
709986003296	PBP superfamily domain; Region: PBP_like_2; cl17296
709986003297	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
709986003298	PhoU domain; Region: PhoU; pfam01895
709986003299	PhoU domain; Region: PhoU; pfam01895
709986003300	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
709986003301	PAS domain; Region: PAS; smart00091
709986003302	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
709986003303	dimer interface [polypeptide binding]; other site
709986003304	phosphorylation site [posttranslational modification]
709986003305	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986003306	ATP binding site [chemical binding]; other site
709986003307	Mg2+ binding site [ion binding]; other site
709986003308	G-X-G motif; other site
709986003309	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
709986003310	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986003311	active site
709986003312	intermolecular recognition site; other site
709986003313	dimerization interface [polypeptide binding]; other site
709986003314	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
709986003315	DNA binding site [nucleotide binding]
709986003316	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
709986003317	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
709986003318	hypothetical protein; Validated; Region: PRK00110
709986003319	Domain of unknown function (DUF4180); Region: DUF4180; pfam13788
709986003320	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
709986003321	active site
709986003322	catalytic triad [active]
709986003323	oxyanion hole [active]
709986003324	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
709986003325	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
709986003326	heme bH binding site [chemical binding]; other site
709986003327	Qi binding site; other site
709986003328	intrachain domain interface; other site
709986003329	heme bL binding site [chemical binding]; other site
709986003330	interchain domain interface [polypeptide binding]; other site
709986003331	Qo binding site; other site
709986003332	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
709986003333	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
709986003334	iron-sulfur cluster [ion binding]; other site
709986003335	[2Fe-2S] cluster binding site [ion binding]; other site
709986003336	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
709986003337	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
709986003338	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
709986003339	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
709986003340	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986003341	active site
709986003342	phosphorylation site [posttranslational modification]
709986003343	intermolecular recognition site; other site
709986003344	dimerization interface [polypeptide binding]; other site
709986003345	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
709986003346	DNA binding residues [nucleotide binding]
709986003347	dimerization interface [polypeptide binding]; other site
709986003348	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
709986003349	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
709986003350	pyridoxal 5'-phosphate binding site [chemical binding]; other site
709986003351	homodimer interface [polypeptide binding]; other site
709986003352	catalytic residue [active]
709986003353	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
709986003354	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
709986003355	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
709986003356	nucleoside/Zn binding site; other site
709986003357	dimer interface [polypeptide binding]; other site
709986003358	catalytic motif [active]
709986003359	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
709986003360	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
709986003361	substrate binding site [chemical binding]; other site
709986003362	dimer interface [polypeptide binding]; other site
709986003363	ATP binding site [chemical binding]; other site
709986003364	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
709986003365	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
709986003366	alpha subunit interface [polypeptide binding]; other site
709986003367	TPP binding site [chemical binding]; other site
709986003368	heterodimer interface [polypeptide binding]; other site
709986003369	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
709986003370	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
709986003371	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
709986003372	tetramer interface [polypeptide binding]; other site
709986003373	TPP-binding site [chemical binding]; other site
709986003374	heterodimer interface [polypeptide binding]; other site
709986003375	phosphorylation loop region [posttranslational modification]
709986003376	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
709986003377	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
709986003378	NAD(P) binding site [chemical binding]; other site
709986003379	catalytic residues [active]
709986003380	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
709986003381	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
709986003382	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
709986003383	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
709986003384	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
709986003385	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
709986003386	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
709986003387	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
709986003388	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986003389	ABC-ATPase subunit interface; other site
709986003390	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
709986003391	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
709986003392	Walker A/P-loop; other site
709986003393	ATP binding site [chemical binding]; other site
709986003394	Q-loop/lid; other site
709986003395	ABC transporter signature motif; other site
709986003396	Walker B; other site
709986003397	D-loop; other site
709986003398	H-loop/switch region; other site
709986003399	Predicted secreted protein (DUF2259); Region: DUF2259; cl02309
709986003400	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
709986003401	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
709986003402	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
709986003403	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
709986003404	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
709986003405	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
709986003406	dimer interface [polypeptide binding]; other site
709986003407	active site
709986003408	von Willebrand factor type A domain; Region: VWA_2; pfam13519
709986003409	metal ion-dependent adhesion site (MIDAS); other site
709986003410	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
709986003411	Transglycosylase; Region: Transgly; pfam00912
709986003412	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
709986003413	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
709986003414	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
709986003415	putative active site [active]
709986003416	Zn binding site [ion binding]; other site
709986003417	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
709986003418	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
709986003419	Putative sensor; Region: Sensor; pfam13796
709986003420	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
709986003421	Histidine kinase; Region: HisKA_3; pfam07730
709986003422	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986003423	ATP binding site [chemical binding]; other site
709986003424	Mg2+ binding site [ion binding]; other site
709986003425	G-X-G motif; other site
709986003426	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
709986003427	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
709986003428	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986003429	active site
709986003430	phosphorylation site [posttranslational modification]
709986003431	intermolecular recognition site; other site
709986003432	dimerization interface [polypeptide binding]; other site
709986003433	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
709986003434	DNA binding residues [nucleotide binding]
709986003435	dimerization interface [polypeptide binding]; other site
709986003436	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
709986003437	Domain of unknown function (DUF4403); Region: DUF4403; pfam14356
709986003438	Predicted thioesterase [General function prediction only]; Region: COG5496
709986003439	EthD domain; Region: EthD; cl17553
709986003440	malate dehydrogenase; Provisional; Region: PRK13529
709986003441	Malic enzyme, N-terminal domain; Region: malic; pfam00390
709986003442	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
709986003443	NAD(P) binding pocket [chemical binding]; other site
709986003444	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
709986003445	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
709986003446	active site
709986003447	catalytic tetrad [active]
709986003448	Protein of unknown function (DUF1045); Region: DUF1045; cl15435
709986003449	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
709986003450	nudix motif; other site
709986003451	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
709986003452	Thioredoxin; Region: Thioredoxin_4; pfam13462
709986003453	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
709986003454	active site
709986003455	DNA binding site [nucleotide binding]
709986003456	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
709986003457	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
709986003458	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
709986003459	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
709986003460	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
709986003461	active site
709986003462	catalytic residues [active]
709986003463	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
709986003464	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
709986003465	putative DNA binding site [nucleotide binding]; other site
709986003466	putative Zn2+ binding site [ion binding]; other site
709986003467	AsnC family; Region: AsnC_trans_reg; pfam01037
709986003468	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
709986003469	EamA-like transporter family; Region: EamA; pfam00892
709986003470	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
709986003471	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
709986003472	FeS/SAM binding site; other site
709986003473	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
709986003474	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
709986003475	iron-sulfur cluster [ion binding]; other site
709986003476	[2Fe-2S] cluster binding site [ion binding]; other site
709986003477	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
709986003478	TPR repeat; Region: TPR_11; pfam13414
709986003479	binding surface
709986003480	TPR motif; other site
709986003481	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
709986003482	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
709986003483	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
709986003484	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
709986003485	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
709986003486	catalytic residues [active]
709986003487	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
709986003488	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
709986003489	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
709986003490	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
709986003491	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
709986003492	Walker A/P-loop; other site
709986003493	ATP binding site [chemical binding]; other site
709986003494	ABC transporter signature motif; other site
709986003495	Walker B; other site
709986003496	D-loop; other site
709986003497	H-loop/switch region; other site
709986003498	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
709986003499	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
709986003500	Transcriptional regulators [Transcription]; Region: MarR; COG1846
709986003501	MarR family; Region: MarR_2; pfam12802
709986003502	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
709986003503	Cytochrome P450; Region: p450; cl12078
709986003504	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
709986003505	CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409
709986003506	active site
709986003507	metal binding site [ion binding]; metal-binding site
709986003508	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
709986003509	peptide synthase; Provisional; Region: PRK09274
709986003510	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
709986003511	acyl-activating enzyme (AAE) consensus motif; other site
709986003512	AMP binding site [chemical binding]; other site
709986003513	active site
709986003514	CoA binding site [chemical binding]; other site
709986003515	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
709986003516	Protein of unknown function (DUF3419); Region: DUF3419; cl15422
709986003517	phosphoenolpyruvate synthase; Validated; Region: PRK06241
709986003518	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
709986003519	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
709986003520	prenyltransferase; Provisional; Region: ubiA; PRK13592
709986003521	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
709986003522	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
709986003523	metal-binding site [ion binding]
709986003524	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
709986003525	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
709986003526	active site
709986003527	motif I; other site
709986003528	motif II; other site
709986003529	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
709986003530	dimerization interface [polypeptide binding]; other site
709986003531	putative DNA binding site [nucleotide binding]; other site
709986003532	putative Zn2+ binding site [ion binding]; other site
709986003533	G8 domain; Region: G8; pfam10162
709986003534	short chain dehydrogenase; Provisional; Region: PRK06701
709986003535	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
709986003536	NAD binding site [chemical binding]; other site
709986003537	metal binding site [ion binding]; metal-binding site
709986003538	active site
709986003539	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
709986003540	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
709986003541	NAD(P) binding site [chemical binding]; other site
709986003542	active site
709986003543	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
709986003544	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
709986003545	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
709986003546	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
709986003547	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
709986003548	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
709986003549	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
709986003550	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
709986003551	signal recognition particle protein; Provisional; Region: PRK10867
709986003552	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
709986003553	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
709986003554	P loop; other site
709986003555	GTP binding site [chemical binding]; other site
709986003556	Signal peptide binding domain; Region: SRP_SPB; pfam02978
709986003557	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
709986003558	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659
709986003559	active site
709986003560	DNA binding site [nucleotide binding]
709986003561	Int/Topo IB signature motif; other site
709986003562	catalytic residues [active]
709986003563	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
709986003564	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
709986003565	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
709986003566	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
709986003567	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
709986003568	YCII-related domain; Region: YCII; cl00999
709986003569	putative acyltransferase; Provisional; Region: PRK05790
709986003570	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
709986003571	dimer interface [polypeptide binding]; other site
709986003572	active site
709986003573	RNA 2'-phosphotransferase; Reviewed; Region: PRK00819
709986003574	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
709986003575	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839
709986003576	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
709986003577	catalytic residues [active]
709986003578	Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790
709986003579	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14358
709986003580	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
709986003581	Substrate binding site; other site
709986003582	Mg++ binding site; other site
709986003583	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
709986003584	active site
709986003585	substrate binding site [chemical binding]; other site
709986003586	CoA binding site [chemical binding]; other site
709986003587	twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411
709986003588	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
709986003589	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
709986003590	Chorismate mutase type II; Region: CM_2; cl00693
709986003591	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
709986003592	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
709986003593	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
709986003594	hypothetical protein; Provisional; Region: PRK08609
709986003595	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
709986003596	metal binding triad [ion binding]; metal-binding site
709986003597	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
709986003598	active site
709986003599	histidinol-phosphatase; Provisional; Region: PRK07328
709986003600	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
709986003601	active site
709986003602	dimer interface [polypeptide binding]; other site
709986003603	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
709986003604	catalytic core [active]
709986003605	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
709986003606	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
709986003607	Phage Tail Collar Domain; Region: Collar; pfam07484
709986003608	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
709986003609	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
709986003610	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
709986003611	FAD binding domain; Region: FAD_binding_2; pfam00890
709986003612	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
709986003613	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
709986003614	Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077
709986003615	calcium binding site 2 [ion binding]; other site
709986003616	active site
709986003617	catalytic triad [active]
709986003618	calcium binding site 1 [ion binding]; other site
709986003619	AFG1-like ATPase; Region: AFG1_ATPase; pfam03969
709986003620	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
709986003621	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
709986003622	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
709986003623	metal binding site [ion binding]; metal-binding site
709986003624	dimer interface [polypeptide binding]; other site
709986003625	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
709986003626	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
709986003627	homotrimer interaction site [polypeptide binding]; other site
709986003628	putative active site [active]
709986003629	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
709986003630	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
709986003631	Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107
709986003632	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
709986003633	Acyltransferase family; Region: Acyl_transf_3; pfam01757
709986003634	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
709986003635	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
709986003636	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
709986003637	active site
709986003638	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
709986003639	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
709986003640	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
709986003641	catalytic site [active]
709986003642	TAP-like protein; Region: Abhydrolase_4; pfam08386
709986003643	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
709986003644	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
709986003645	NAD(P) binding site [chemical binding]; other site
709986003646	active site
709986003647	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
709986003648	putative active site [active]
709986003649	putative catalytic site [active]
709986003650	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
709986003651	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
709986003652	FAD binding site [chemical binding]; other site
709986003653	substrate binding site [chemical binding]; other site
709986003654	catalytic base [active]
709986003655	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
709986003656	classical (c) SDRs; Region: SDR_c; cd05233
709986003657	NAD(P) binding site [chemical binding]; other site
709986003658	active site
709986003659	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
709986003660	putative active site [active]
709986003661	putative substrate binding site [chemical binding]; other site
709986003662	ATP binding site [chemical binding]; other site
709986003663	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
709986003664	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
709986003665	catalytic core [active]
709986003666	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
709986003667	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
709986003668	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
709986003669	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
709986003670	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
709986003671	molybdopterin cofactor binding site; other site
709986003672	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
709986003673	molybdopterin cofactor binding site; other site
709986003674	enterobactin exporter EntS; Provisional; Region: PRK10489
709986003675	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
709986003676	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
709986003677	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
709986003678	active site
709986003679	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
709986003680	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
709986003681	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
709986003682	active site
709986003683	catalytic tetrad [active]
709986003684	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
709986003685	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
709986003686	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
709986003687	arginine decarboxylase; Provisional; Region: PRK05354
709986003688	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
709986003689	dimer interface [polypeptide binding]; other site
709986003690	active site
709986003691	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
709986003692	catalytic residues [active]
709986003693	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
709986003694	HYR domain; Region: HYR; pfam02494
709986003695	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
709986003696	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
709986003697	S-adenosylmethionine binding site [chemical binding]; other site
709986003698	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
709986003699	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
709986003700	substrate binding pocket [chemical binding]; other site
709986003701	membrane-bound complex binding site; other site
709986003702	hinge residues; other site
709986003703	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
709986003704	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986003705	dimer interface [polypeptide binding]; other site
709986003706	conserved gate region; other site
709986003707	putative PBP binding loops; other site
709986003708	ABC-ATPase subunit interface; other site
709986003709	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
709986003710	Histidine kinase; Region: HisKA_3; pfam07730
709986003711	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986003712	ATP binding site [chemical binding]; other site
709986003713	Mg2+ binding site [ion binding]; other site
709986003714	G-X-G motif; other site
709986003715	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
709986003716	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986003717	active site
709986003718	phosphorylation site [posttranslational modification]
709986003719	intermolecular recognition site; other site
709986003720	dimerization interface [polypeptide binding]; other site
709986003721	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
709986003722	DNA binding residues [nucleotide binding]
709986003723	dimerization interface [polypeptide binding]; other site
709986003724	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
709986003725	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
709986003726	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK14662
709986003727	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
709986003728	active site
709986003729	NTP binding site [chemical binding]; other site
709986003730	metal binding triad [ion binding]; metal-binding site
709986003731	antibiotic binding site [chemical binding]; other site
709986003732	Uncharacterized conserved protein [Function unknown]; Region: COG2361
709986003733	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
709986003734	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
709986003735	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986003736	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986003737	metal binding site [ion binding]; metal-binding site
709986003738	active site
709986003739	I-site; other site
709986003740	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
709986003741	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
709986003742	Walker A/P-loop; other site
709986003743	ATP binding site [chemical binding]; other site
709986003744	Q-loop/lid; other site
709986003745	ABC transporter signature motif; other site
709986003746	Walker B; other site
709986003747	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
709986003748	Ligand binding site [chemical binding]; other site
709986003749	Electron transfer flavoprotein domain; Region: ETF; pfam01012
709986003750	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
709986003751	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
709986003752	Ligand Binding Site [chemical binding]; other site
709986003753	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
709986003754	Tetratricopeptide repeat; Region: TPR_12; pfam13424
709986003755	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986003756	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986003757	metal binding site [ion binding]; metal-binding site
709986003758	active site
709986003759	I-site; other site
709986003760	Flagellin N-methylase; Region: FliB; cl00497
709986003761	GAF domain; Region: GAF_3; pfam13492
709986003762	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
709986003763	Zn2+ binding site [ion binding]; other site
709986003764	Mg2+ binding site [ion binding]; other site
709986003765	Phosphotransferase enzyme family; Region: APH; pfam01636
709986003766	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
709986003767	active site
709986003768	substrate binding site [chemical binding]; other site
709986003769	ATP binding site [chemical binding]; other site
709986003770	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
709986003771	active site
709986003772	Protein of unknown function (DUF1517); Region: DUF1517; cl01807
709986003773	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
709986003774	DNA-binding site [nucleotide binding]; DNA binding site
709986003775	RNA-binding motif; other site
709986003776	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
709986003777	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
709986003778	ligand binding site [chemical binding]; other site
709986003779	isocitrate lyase; Provisional; Region: PRK15063
709986003780	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
709986003781	tetramer interface [polypeptide binding]; other site
709986003782	active site
709986003783	Mg2+/Mn2+ binding site [ion binding]; other site
709986003784	malate synthase A; Region: malate_syn_A; TIGR01344
709986003785	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
709986003786	active site
709986003787	Predicted ATPase [General function prediction only]; Region: COG3903
709986003788	Tetratricopeptide repeat; Region: TPR_12; pfam13424
709986003789	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
709986003790	binding surface
709986003791	TPR motif; other site
709986003792	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
709986003793	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
709986003794	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
709986003795	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
709986003796	active site
709986003797	homodimer interface [polypeptide binding]; other site
709986003798	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
709986003799	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
709986003800	Mg++ binding site [ion binding]; other site
709986003801	putative catalytic motif [active]
709986003802	substrate binding site [chemical binding]; other site
709986003803	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
709986003804	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
709986003805	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
709986003806	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
709986003807	NAD(P) binding site [chemical binding]; other site
709986003808	active site
709986003809	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
709986003810	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
709986003811	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
709986003812	putative substrate translocation pore; other site
709986003813	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
709986003814	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
709986003815	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
709986003816	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
709986003817	active site
709986003818	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
709986003819	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
709986003820	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
709986003821	Peptidase family M50; Region: Peptidase_M50; pfam02163
709986003822	active site
709986003823	putative substrate binding region [chemical binding]; other site
709986003824	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
709986003825	active site
709986003826	putative substrate binding region [chemical binding]; other site
709986003827	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
709986003828	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
709986003829	metal binding triad [ion binding]; metal-binding site
709986003830	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
709986003831	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
709986003832	butyrate kinase; Provisional; Region: PRK03011
709986003833	Aminotransferase class IV; Region: Aminotran_4; pfam01063
709986003834	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
709986003835	substrate-cofactor binding pocket; other site
709986003836	pyridoxal 5'-phosphate binding site [chemical binding]; other site
709986003837	catalytic residue [active]
709986003838	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
709986003839	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
709986003840	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
709986003841	Glutamine amidotransferase class-I; Region: GATase; pfam00117
709986003842	glutamine binding [chemical binding]; other site
709986003843	catalytic triad [active]
709986003844	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
709986003845	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986003846	active site
709986003847	phosphorylation site [posttranslational modification]
709986003848	intermolecular recognition site; other site
709986003849	dimerization interface [polypeptide binding]; other site
709986003850	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
709986003851	DNA binding residues [nucleotide binding]
709986003852	dimerization interface [polypeptide binding]; other site
709986003853	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
709986003854	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
709986003855	motif II; other site
709986003856	Protein of unknown function (DUF3208); Region: DUF3208; pfam11482
709986003857	Putative amidotransferase; Region: DUF4066; pfam13278
709986003858	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
709986003859	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
709986003860	DNA binding residues [nucleotide binding]
709986003861	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
709986003862	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
709986003863	DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466
709986003864	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
709986003865	Protein kinase; unclassified specificity; Region: STYKc; smart00221
709986003866	Catalytic domain of Protein Kinases; Region: PKc; cd00180
709986003867	active site
709986003868	ATP binding site [chemical binding]; other site
709986003869	substrate binding site [chemical binding]; other site
709986003870	activation loop (A-loop); other site
709986003871	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
709986003872	dimer interface [polypeptide binding]; other site
709986003873	active site
709986003874	Schiff base residues; other site
709986003875	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
709986003876	Cytochrome P450; Region: p450; cl12078
709986003877	Cytochrome P450; Region: p450; cl12078
709986003878	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
709986003879	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
709986003880	catalytic loop [active]
709986003881	iron binding site [ion binding]; other site
709986003882	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
709986003883	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
709986003884	L-aspartate oxidase; Provisional; Region: PRK06175
709986003885	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
709986003886	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500
709986003887	putative Iron-sulfur protein interface [polypeptide binding]; other site
709986003888	putative proximal heme binding site [chemical binding]; other site
709986003889	putative SdhC-like subunit interface [polypeptide binding]; other site
709986003890	putative distal heme binding site [chemical binding]; other site
709986003891	Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881
709986003892	Iron-sulfur protein interface; other site
709986003893	proximal heme binding site [chemical binding]; other site
709986003894	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687
709986003895	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
709986003896	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
709986003897	active site
709986003898	ATP binding site [chemical binding]; other site
709986003899	substrate binding site [chemical binding]; other site
709986003900	activation loop (A-loop); other site
709986003901	Uncharacterized conserved protein [Function unknown]; Region: COG3391
709986003902	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
709986003903	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
709986003904	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
709986003905	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
709986003906	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
709986003907	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
709986003908	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
709986003909	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
709986003910	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
709986003911	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
709986003912	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
709986003913	Catalytic domain of Protein Kinases; Region: PKc; cd00180
709986003914	active site
709986003915	ATP binding site [chemical binding]; other site
709986003916	substrate binding site [chemical binding]; other site
709986003917	activation loop (A-loop); other site
709986003918	PQQ-like domain; Region: PQQ_2; pfam13360
709986003919	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
709986003920	Trp docking motif [polypeptide binding]; other site
709986003921	active site
709986003922	PQQ-like domain; Region: PQQ_2; pfam13360
709986003923	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
709986003924	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
709986003925	hinge; other site
709986003926	active site
709986003927	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
709986003928	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
709986003929	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
709986003930	The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637
709986003931	dimer interface [polypeptide binding]; other site
709986003932	active site
709986003933	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
709986003934	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
709986003935	active site
709986003936	Response regulator receiver domain; Region: Response_reg; pfam00072
709986003937	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986003938	active site
709986003939	phosphorylation site [posttranslational modification]
709986003940	intermolecular recognition site; other site
709986003941	dimerization interface [polypeptide binding]; other site
709986003942	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
709986003943	DNA-binding site [nucleotide binding]; DNA binding site
709986003944	RNA-binding motif; other site
709986003945	Uncharacterized conserved protein [Function unknown]; Region: COG1801
709986003946	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
709986003947	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
709986003948	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
709986003949	catalytic loop [active]
709986003950	iron binding site [ion binding]; other site
709986003951	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
709986003952	4Fe-4S binding domain; Region: Fer4; pfam00037
709986003953	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
709986003954	[4Fe-4S] binding site [ion binding]; other site
709986003955	molybdopterin cofactor binding site; other site
709986003956	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
709986003957	molybdopterin cofactor binding site; other site
709986003958	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
709986003959	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
709986003960	Walker A/P-loop; other site
709986003961	ATP binding site [chemical binding]; other site
709986003962	Q-loop/lid; other site
709986003963	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
709986003964	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
709986003965	Walker A/P-loop; other site
709986003966	ATP binding site [chemical binding]; other site
709986003967	Q-loop/lid; other site
709986003968	ABC transporter signature motif; other site
709986003969	Walker B; other site
709986003970	D-loop; other site
709986003971	H-loop/switch region; other site
709986003972	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
709986003973	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
709986003974	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
709986003975	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
709986003976	FOG: CBS domain [General function prediction only]; Region: COG0517
709986003977	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
709986003978	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
709986003979	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
709986003980	substrate binding pocket [chemical binding]; other site
709986003981	chain length determination region; other site
709986003982	substrate-Mg2+ binding site; other site
709986003983	catalytic residues [active]
709986003984	aspartate-rich region 1; other site
709986003985	active site lid residues [active]
709986003986	aspartate-rich region 2; other site
709986003987	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
709986003988	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
709986003989	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
709986003990	dimerization interface [polypeptide binding]; other site
709986003991	putative ATP binding site [chemical binding]; other site
709986003992	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
709986003993	catalytic core [active]
709986003994	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
709986003995	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
709986003996	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
709986003997	B12 binding site [chemical binding]; other site
709986003998	cobalt ligand [ion binding]; other site
709986003999	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
709986004000	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
709986004001	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
709986004002	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
709986004003	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
709986004004	active site
709986004005	HIGH motif; other site
709986004006	dimer interface [polypeptide binding]; other site
709986004007	KMSKS motif; other site
709986004008	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
709986004009	FOG: CBS domain [General function prediction only]; Region: COG0517
709986004010	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
709986004011	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
709986004012	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
709986004013	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
709986004014	AAK_NAGK-UC: N-Acetyl-L-glutamate kinase - uncharacterized (NAGK-UC). This domain is similar to Escherichia coli and Pseudomonas aeruginosa NAGKs which catalyze the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the...; Region: AAK_NAGK-UC; cd04251
709986004015	putative nucleotide binding site [chemical binding]; other site
709986004016	putative N-acetyl-L-glutamate binding site [chemical binding]; other site
709986004017	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
709986004018	active site
709986004019	catalytic triad [active]
709986004020	oxyanion hole [active]
709986004021	Response regulator receiver domain; Region: Response_reg; pfam00072
709986004022	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986004023	active site
709986004024	phosphorylation site [posttranslational modification]
709986004025	intermolecular recognition site; other site
709986004026	dimerization interface [polypeptide binding]; other site
709986004027	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
709986004028	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
709986004029	Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144
709986004030	ATP-grasp domain; Region: ATP-grasp_4; cl17255
709986004031	lysine biosynthesis protein LysW; Region: lysW; TIGR01206
709986004032	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
709986004033	homoaconitate hydratase small subunit; Provisional; Region: PRK14023
709986004034	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
709986004035	substrate binding site [chemical binding]; other site
709986004036	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
709986004037	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
709986004038	substrate binding site [chemical binding]; other site
709986004039	ligand binding site [chemical binding]; other site
709986004040	Benzoate membrane transport protein; Region: BenE; pfam03594
709986004041	benzoate transporter; Region: benE; TIGR00843
709986004042	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
709986004043	Saccharomyces cerevisiae homocitrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_HCS; cd07948
709986004044	homocitrate synthase; Region: LysS_fung_arch; TIGR02146
709986004045	active site
709986004046	catalytic residues [active]
709986004047	metal binding site [ion binding]; metal-binding site
709986004048	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
709986004049	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
709986004050	active site
709986004051	catalytic tetrad [active]
709986004052	CHASE3 domain; Region: CHASE3; pfam05227
709986004053	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
709986004054	dimerization interface [polypeptide binding]; other site
709986004055	GAF domain; Region: GAF_3; pfam13492
709986004056	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986004057	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986004058	metal binding site [ion binding]; metal-binding site
709986004059	active site
709986004060	I-site; other site
709986004061	DinB superfamily; Region: DinB_2; pfam12867
709986004062	metal-dependent hydrolase; Provisional; Region: PRK13291
709986004063	Transcriptional regulators [Transcription]; Region: GntR; COG1802
709986004064	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
709986004065	DNA-binding site [nucleotide binding]; DNA binding site
709986004066	FCD domain; Region: FCD; pfam07729
709986004067	Proline dehydrogenase; Region: Pro_dh; cl03282
709986004068	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
709986004069	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
709986004070	Glutamate binding site [chemical binding]; other site
709986004071	homodimer interface [polypeptide binding]; other site
709986004072	NAD binding site [chemical binding]; other site
709986004073	catalytic residues [active]
709986004074	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
709986004075	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
709986004076	active site
709986004077	catalytic residues [active]
709986004078	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
709986004079	putative integrin binding motif; other site
709986004080	PA/protease domain interface [polypeptide binding]; other site
709986004081	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
709986004082	catalytic residues [active]
709986004083	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
709986004084	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
709986004085	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
709986004086	metal binding site [ion binding]; metal-binding site
709986004087	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
709986004088	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
709986004089	substrate binding site [chemical binding]; other site
709986004090	glutamase interaction surface [polypeptide binding]; other site
709986004091	PBP superfamily domain; Region: PBP_like_2; cl17296
709986004092	LrgB-like family; Region: LrgB; cl00596
709986004093	LrgA family; Region: LrgA; pfam03788
709986004094	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
709986004095	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
709986004096	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
709986004097	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
709986004098	pyridoxal 5'-phosphate binding site [chemical binding]; other site
709986004099	homodimer interface [polypeptide binding]; other site
709986004100	catalytic residue [active]
709986004101	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
709986004102	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
709986004103	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
709986004104	active site
709986004105	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
709986004106	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
709986004107	dimer interface [polypeptide binding]; other site
709986004108	pyridoxal 5'-phosphate binding site [chemical binding]; other site
709986004109	catalytic residue [active]
709986004110	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
709986004111	active site
709986004112	metal binding site [ion binding]; metal-binding site
709986004113	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
709986004114	mevalonate kinase; Region: mevalon_kin; TIGR00549
709986004115	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
709986004116	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
709986004117	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
709986004118	nucleotide binding site/active site [active]
709986004119	HIT family signature motif; other site
709986004120	catalytic residue [active]
709986004121	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
709986004122	Fasciclin domain; Region: Fasciclin; pfam02469
709986004123	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
709986004124	Fasciclin domain; Region: Fasciclin; pfam02469
709986004125	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
709986004126	Fasciclin domain; Region: Fasciclin; pfam02469
709986004127	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
709986004128	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
709986004129	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
709986004130	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
709986004131	MPN+ (JAMM) motif; other site
709986004132	Zinc-binding site [ion binding]; other site
709986004133	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
709986004134	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
709986004135	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
709986004136	NlpC/P60 family; Region: NLPC_P60; pfam00877
709986004137	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
709986004138	active site
709986004139	catalytic triad [active]
709986004140	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
709986004141	Clp amino terminal domain; Region: Clp_N; pfam02861
709986004142	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
709986004143	Walker A motif; other site
709986004144	ATP binding site [chemical binding]; other site
709986004145	Walker B motif; other site
709986004146	arginine finger; other site
709986004147	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
709986004148	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
709986004149	Walker A motif; other site
709986004150	ATP binding site [chemical binding]; other site
709986004151	Walker B motif; other site
709986004152	arginine finger; other site
709986004153	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
709986004154	MgtC family; Region: MgtC; pfam02308
709986004155	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
709986004156	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
709986004157	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
709986004158	putative active site [active]
709986004159	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
709986004160	arsenical pump membrane protein; Provisional; Region: PRK15445
709986004161	transmembrane helices; other site
709986004162	phosphoglucomutase; Validated; Region: PRK07564
709986004163	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
709986004164	active site
709986004165	substrate binding site [chemical binding]; other site
709986004166	metal binding site [ion binding]; metal-binding site
709986004167	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
709986004168	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
709986004169	Zn2+ binding site [ion binding]; other site
709986004170	Mg2+ binding site [ion binding]; other site
709986004171	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
709986004172	active site
709986004173	metal binding site [ion binding]; metal-binding site
709986004174	homotetramer interface [polypeptide binding]; other site
709986004175	Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563
709986004176	AAA domain; Region: AAA_17; pfam13207
709986004177	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
709986004178	maltodextrin glucosidase; Provisional; Region: PRK10785
709986004179	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
709986004180	active site
709986004181	homodimer interface [polypeptide binding]; other site
709986004182	catalytic site [active]
709986004183	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
709986004184	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
709986004185	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986004186	dimer interface [polypeptide binding]; other site
709986004187	conserved gate region; other site
709986004188	putative PBP binding loops; other site
709986004189	ABC-ATPase subunit interface; other site
709986004190	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
709986004191	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986004192	dimer interface [polypeptide binding]; other site
709986004193	conserved gate region; other site
709986004194	putative PBP binding loops; other site
709986004195	ABC-ATPase subunit interface; other site
709986004196	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
709986004197	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
709986004198	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
709986004199	Major Facilitator Superfamily; Region: MFS_1; pfam07690
709986004200	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
709986004201	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
709986004202	active site
709986004203	catalytic tetrad [active]
709986004204	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
709986004205	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
709986004206	active site residue [active]
709986004207	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: PspE; COG0607
709986004208	active site residue [active]
709986004209	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
709986004210	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
709986004211	TAP-like protein; Region: Abhydrolase_4; pfam08386
709986004212	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
709986004213	Peptidase family U32; Region: Peptidase_U32; pfam01136
709986004214	Collagenase; Region: DUF3656; pfam12392
709986004215	Peptidase family U32; Region: Peptidase_U32; cl03113
709986004216	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
709986004217	Protein of unknown function (DUF402); Region: DUF402; cl00979
709986004218	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
709986004219	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986004220	active site
709986004221	phosphorylation site [posttranslational modification]
709986004222	intermolecular recognition site; other site
709986004223	dimerization interface [polypeptide binding]; other site
709986004224	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
709986004225	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986004226	ATP binding site [chemical binding]; other site
709986004227	Mg2+ binding site [ion binding]; other site
709986004228	G-X-G motif; other site
709986004229	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
709986004230	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
709986004231	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
709986004232	CoenzymeA binding site [chemical binding]; other site
709986004233	subunit interaction site [polypeptide binding]; other site
709986004234	PHB binding site; other site
709986004235	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
709986004236	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
709986004237	Walker A/P-loop; other site
709986004238	ATP binding site [chemical binding]; other site
709986004239	Q-loop/lid; other site
709986004240	ABC transporter signature motif; other site
709986004241	Walker B; other site
709986004242	D-loop; other site
709986004243	H-loop/switch region; other site
709986004244	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
709986004245	Transcriptional regulator [Transcription]; Region: LysR; COG0583
709986004246	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
709986004247	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
709986004248	putative substrate binding pocket [chemical binding]; other site
709986004249	putative dimerization interface [polypeptide binding]; other site
709986004250	pilus retraction protein PilT; Region: pilT_fam; TIGR01420
709986004251	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
709986004252	Walker A motif; other site
709986004253	ATP binding site [chemical binding]; other site
709986004254	Walker B motif; other site
709986004255	DinB superfamily; Region: DinB_2; pfam12867
709986004256	Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14603
709986004257	RuvA N terminal domain; Region: RuvA_N; pfam01330
709986004258	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
709986004259	PAS fold; Region: PAS_4; pfam08448
709986004260	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986004261	putative active site [active]
709986004262	heme pocket [chemical binding]; other site
709986004263	PAS domain; Region: PAS_9; pfam13426
709986004264	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
709986004265	dimer interface [polypeptide binding]; other site
709986004266	phosphorylation site [posttranslational modification]
709986004267	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986004268	ATP binding site [chemical binding]; other site
709986004269	Mg2+ binding site [ion binding]; other site
709986004270	G-X-G motif; other site
709986004271	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
709986004272	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
709986004273	Catalytic site [active]
709986004274	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
709986004275	DNA polymerase I; Provisional; Region: PRK05755
709986004276	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
709986004277	active site
709986004278	metal binding site 1 [ion binding]; metal-binding site
709986004279	putative 5' ssDNA interaction site; other site
709986004280	metal binding site 3; metal-binding site
709986004281	metal binding site 2 [ion binding]; metal-binding site
709986004282	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
709986004283	putative DNA binding site [nucleotide binding]; other site
709986004284	putative metal binding site [ion binding]; other site
709986004285	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
709986004286	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
709986004287	active site
709986004288	DNA binding site [nucleotide binding]
709986004289	catalytic site [active]
709986004290	methionine sulfoxide reductase B; Provisional; Region: PRK00222
709986004291	SelR domain; Region: SelR; pfam01641
709986004292	Domain of unknown function (DUF2383); Region: DUF2383; cl17556
709986004293	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
709986004294	dimerization interface [polypeptide binding]; other site
709986004295	Protein of unknown function (DUF2847); Region: DUF2847; cl17683
709986004296	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
709986004297	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
709986004298	putative acyltransferase; Provisional; Region: PRK05790
709986004299	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
709986004300	dimer interface [polypeptide binding]; other site
709986004301	active site
709986004302	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
709986004303	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986004304	active site
709986004305	phosphorylation site [posttranslational modification]
709986004306	intermolecular recognition site; other site
709986004307	dimerization interface [polypeptide binding]; other site
709986004308	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
709986004309	DNA binding residues [nucleotide binding]
709986004310	dimerization interface [polypeptide binding]; other site
709986004311	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
709986004312	Histidine kinase; Region: HisKA_3; pfam07730
709986004313	Predicted membrane protein [Function unknown]; Region: COG4270
709986004314	30S ribosomal protein S1; Provisional; Region: rpsA; PRK13806
709986004315	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
709986004316	RNA binding site [nucleotide binding]; other site
709986004317	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
709986004318	RNA binding site [nucleotide binding]; other site
709986004319	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
709986004320	RNA binding site [nucleotide binding]; other site
709986004321	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
709986004322	RNA binding site [nucleotide binding]; other site
709986004323	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
709986004324	RNA binding site [nucleotide binding]; other site
709986004325	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
709986004326	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
709986004327	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
709986004328	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
709986004329	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
709986004330	active site
709986004331	motif I; other site
709986004332	motif II; other site
709986004333	UV-endonuclease UvdE; Region: UvdE; cl10036
709986004334	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
709986004335	nudix motif; other site
709986004336	peptide chain release factor 1; Validated; Region: prfA; PRK00591
709986004337	PCRF domain; Region: PCRF; pfam03462
709986004338	RF-1 domain; Region: RF-1; pfam00472
709986004339	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
709986004340	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
709986004341	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
709986004342	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
709986004343	substrate binding pocket [chemical binding]; other site
709986004344	chain length determination region; other site
709986004345	substrate-Mg2+ binding site; other site
709986004346	catalytic residues [active]
709986004347	aspartate-rich region 1; other site
709986004348	active site lid residues [active]
709986004349	aspartate-rich region 2; other site
709986004350	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
709986004351	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
709986004352	active site
709986004353	HIGH motif; other site
709986004354	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
709986004355	KMSKS motif; other site
709986004356	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
709986004357	tRNA binding surface [nucleotide binding]; other site
709986004358	anticodon binding site; other site
709986004359	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
709986004360	metal ion-dependent adhesion site (MIDAS); other site
709986004361	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
709986004362	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986004363	Mg2+ binding site [ion binding]; other site
709986004364	G-X-G motif; other site
709986004365	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
709986004366	anchoring element; other site
709986004367	dimer interface [polypeptide binding]; other site
709986004368	ATP binding site [chemical binding]; other site
709986004369	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
709986004370	active site
709986004371	putative metal-binding site [ion binding]; other site
709986004372	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
709986004373	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
709986004374	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
709986004375	putative homodimer interface [polypeptide binding]; other site
709986004376	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
709986004377	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
709986004378	UDP-galactopyranose mutase; Region: GLF; pfam03275
709986004379	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
709986004380	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
709986004381	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
709986004382	NADP binding site [chemical binding]; other site
709986004383	active site
709986004384	putative substrate binding site [chemical binding]; other site
709986004385	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
709986004386	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
709986004387	Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326
709986004388	SpoOM protein; Region: Spo0M; pfam07070
709986004389	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
709986004390	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
709986004391	active site
709986004392	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
709986004393	histidinol dehydrogenase; Region: hisD; TIGR00069
709986004394	NAD binding site [chemical binding]; other site
709986004395	dimerization interface [polypeptide binding]; other site
709986004396	product binding site; other site
709986004397	substrate binding site [chemical binding]; other site
709986004398	zinc binding site [ion binding]; other site
709986004399	catalytic residues [active]
709986004400	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
709986004401	phosphopentomutase; Provisional; Region: PRK05362
709986004402	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
709986004403	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
709986004404	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
709986004405	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
709986004406	Walker A/P-loop; other site
709986004407	ATP binding site [chemical binding]; other site
709986004408	Q-loop/lid; other site
709986004409	ABC transporter signature motif; other site
709986004410	Walker B; other site
709986004411	D-loop; other site
709986004412	H-loop/switch region; other site
709986004413	Protein of unknown function (DUF3084); Region: DUF3084; pfam11283
709986004414	Peptidase M36 family also known as fungalysin family; Region: M36; cd09596
709986004415	Zn binding site [ion binding]; other site
709986004416	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
709986004417	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
709986004418	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
709986004419	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
709986004420	catalytic residue [active]
709986004421	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
709986004422	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
709986004423	catalytic residues [active]
709986004424	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
709986004425	catalytic triad [active]
709986004426	putative active site [active]
709986004427	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
709986004428	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
709986004429	PapC C-terminal domain; Region: PapC_C; pfam13953
709986004430	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
709986004431	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
709986004432	Spore Coat Protein U domain; Region: SCPU; pfam05229
709986004433	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
709986004434	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
709986004435	PDZ domain; Region: PDZ_2; pfam13180
709986004436	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
709986004437	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986004438	active site
709986004439	phosphorylation site [posttranslational modification]
709986004440	intermolecular recognition site; other site
709986004441	dimerization interface [polypeptide binding]; other site
709986004442	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
709986004443	DNA binding site [nucleotide binding]
709986004444	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
709986004445	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986004446	ATP binding site [chemical binding]; other site
709986004447	Mg2+ binding site [ion binding]; other site
709986004448	G-X-G motif; other site
709986004449	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
709986004450	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
709986004451	B12 binding site [chemical binding]; other site
709986004452	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
709986004453	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
709986004454	FeS/SAM binding site; other site
709986004455	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
709986004456	S-adenosylmethionine binding site [chemical binding]; other site
709986004457	isocitrate dehydrogenase; Reviewed; Region: PRK07006
709986004458	isocitrate dehydrogenase; Validated; Region: PRK07362
709986004459	Transcriptional regulators [Transcription]; Region: MarR; COG1846
709986004460	MarR family; Region: MarR_2; pfam12802
709986004461	Major Facilitator Superfamily; Region: MFS_1; pfam07690
709986004462	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
709986004463	putative substrate translocation pore; other site
709986004464	Protein of unknown function (DUF2167); Region: DUF2167; cl01938
709986004465	Methyltransferase domain; Region: Methyltransf_23; pfam13489
709986004466	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
709986004467	S-adenosylmethionine binding site [chemical binding]; other site
709986004468	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
709986004469	Low molecular weight phosphatase family; Region: LMWPc; cl00105
709986004470	active site
709986004471	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
709986004472	2-isopropylmalate synthase; Validated; Region: PRK00915
709986004473	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
709986004474	active site
709986004475	catalytic residues [active]
709986004476	metal binding site [ion binding]; metal-binding site
709986004477	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
709986004478	ketol-acid reductoisomerase; Provisional; Region: PRK05479
709986004479	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
709986004480	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
709986004481	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
709986004482	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
709986004483	putative valine binding site [chemical binding]; other site
709986004484	dimer interface [polypeptide binding]; other site
709986004485	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
709986004486	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
709986004487	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
709986004488	PYR/PP interface [polypeptide binding]; other site
709986004489	dimer interface [polypeptide binding]; other site
709986004490	TPP binding site [chemical binding]; other site
709986004491	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
709986004492	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
709986004493	TPP-binding site [chemical binding]; other site
709986004494	dimer interface [polypeptide binding]; other site
709986004495	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
709986004496	tartrate dehydrogenase; Region: TTC; TIGR02089
709986004497	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
709986004498	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
709986004499	substrate binding site [chemical binding]; other site
709986004500	LysE type translocator; Region: LysE; cl00565
709986004501	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
709986004502	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
709986004503	substrate binding site [chemical binding]; other site
709986004504	ligand binding site [chemical binding]; other site
709986004505	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
709986004506	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607
709986004507	active site
709986004508	Zn binding site [ion binding]; other site
709986004509	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
709986004510	putative active site [active]
709986004511	DNA repair protein RadA; Provisional; Region: PRK11823
709986004512	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
709986004513	Walker A motif; other site
709986004514	ATP binding site [chemical binding]; other site
709986004515	Walker B motif; other site
709986004516	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
709986004517	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
709986004518	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
709986004519	Clp amino terminal domain; Region: Clp_N; pfam02861
709986004520	Clp amino terminal domain; Region: Clp_N; pfam02861
709986004521	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
709986004522	Walker A motif; other site
709986004523	ATP binding site [chemical binding]; other site
709986004524	Walker B motif; other site
709986004525	arginine finger; other site
709986004526	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
709986004527	Walker A motif; other site
709986004528	ATP binding site [chemical binding]; other site
709986004529	Walker B motif; other site
709986004530	arginine finger; other site
709986004531	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
709986004532	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
709986004533	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
709986004534	putative active site [active]
709986004535	putative CoA binding site [chemical binding]; other site
709986004536	nudix motif; other site
709986004537	metal binding site [ion binding]; metal-binding site
709986004538	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
709986004539	homodimer interface [polypeptide binding]; other site
709986004540	metal binding site [ion binding]; metal-binding site
709986004541	short chain dehydrogenase; Provisional; Region: PRK07326
709986004542	classical (c) SDR, subgroup 4; Region: SDR_c4; cd08929
709986004543	putative NAD(P) binding site [chemical binding]; other site
709986004544	homodimer interface [polypeptide binding]; other site
709986004545	active site
709986004546	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
709986004547	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
709986004548	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
709986004549	Zn2+ binding site [ion binding]; other site
709986004550	Mg2+ binding site [ion binding]; other site
709986004551	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
709986004552	synthetase active site [active]
709986004553	NTP binding site [chemical binding]; other site
709986004554	metal binding site [ion binding]; metal-binding site
709986004555	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
709986004556	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
709986004557	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
709986004558	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
709986004559	active site
709986004560	Zn binding site [ion binding]; other site
709986004561	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
709986004562	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
709986004563	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
709986004564	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
709986004565	23S rRNA interface [nucleotide binding]; other site
709986004566	L3 interface [polypeptide binding]; other site
709986004567	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
709986004568	Dehydroquinase class II; Region: DHquinase_II; pfam01220
709986004569	active site
709986004570	trimer interface [polypeptide binding]; other site
709986004571	dimer interface [polypeptide binding]; other site
709986004572	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
709986004573	active site
709986004574	dimer interface [polypeptide binding]; other site
709986004575	metal binding site [ion binding]; metal-binding site
709986004576	shikimate kinase; Provisional; Region: PRK13948
709986004577	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
709986004578	ADP binding site [chemical binding]; other site
709986004579	magnesium binding site [ion binding]; other site
709986004580	putative shikimate binding site; other site
709986004581	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
709986004582	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
709986004583	Tetramer interface [polypeptide binding]; other site
709986004584	active site
709986004585	FMN-binding site [chemical binding]; other site
709986004586	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
709986004587	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
709986004588	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
709986004589	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
709986004590	type IV pilus assembly protein PilM; Region: pilM; TIGR01175
709986004591	Cell division protein FtsA; Region: FtsA; pfam14450
709986004592	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
709986004593	tartrate dehydrogenase; Region: TTC; TIGR02089
709986004594	FAD dependent oxidoreductase; Region: DAO; pfam01266
709986004595	Uncharacterized conserved protein [Function unknown]; Region: COG4121
709986004596	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
709986004597	putative hydrolase; Provisional; Region: PRK11460
709986004598	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
709986004599	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
709986004600	Zn binding site [ion binding]; other site
709986004601	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
709986004602	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
709986004603	Zn binding site [ion binding]; other site
709986004604	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986004605	active site
709986004606	I-site; other site
709986004607	metal binding site [ion binding]; metal-binding site
709986004608	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
709986004609	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
709986004610	MarR family; Region: MarR; pfam01047
709986004611	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
709986004612	active site
709986004613	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
709986004614	tandem repeat interface [polypeptide binding]; other site
709986004615	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
709986004616	oligomer interface [polypeptide binding]; other site
709986004617	active site residues [active]
709986004618	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
709986004619	heme-binding site [chemical binding]; other site
709986004620	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
709986004621	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
709986004622	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
709986004623	intersubunit interface [polypeptide binding]; other site
709986004624	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
709986004625	Zn binding site [ion binding]; other site
709986004626	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
709986004627	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
709986004628	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
709986004629	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
709986004630	PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616
709986004631	Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348
709986004632	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
709986004633	Putative cyclase; Region: Cyclase; cl00814
709986004634	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
709986004635	kynureninase; Region: kynureninase; TIGR01814
709986004636	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
709986004637	catalytic residue [active]
709986004638	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
709986004639	active site
709986004640	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
709986004641	Outer membrane efflux protein; Region: OEP; pfam02321
709986004642	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
709986004643	HlyD family secretion protein; Region: HlyD_3; pfam13437
709986004644	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
709986004645	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
709986004646	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
709986004647	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
709986004648	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
709986004649	nudix motif; other site
709986004650	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
709986004651	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
709986004652	HIGH motif; other site
709986004653	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
709986004654	active site
709986004655	KMSKS motif; other site
709986004656	META domain; Region: META; pfam03724
709986004657	META domain; Region: META; pfam03724
709986004658	META domain; Region: META; pfam03724
709986004659	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
709986004660	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
709986004661	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
709986004662	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
709986004663	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
709986004664	motif II; other site
709986004665	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
709986004666	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
709986004667	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
709986004668	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
709986004669	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
709986004670	putative L-serine binding site [chemical binding]; other site
709986004671	lycopene cyclase family protein; Region: carotene-cycl; TIGR01790
709986004672	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
709986004673	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
709986004674	substrate binding pocket [chemical binding]; other site
709986004675	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
709986004676	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
709986004677	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
709986004678	LysM domain; Region: LysM; pfam01476
709986004679	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
709986004680	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
709986004681	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
709986004682	HerA helicase [Replication, recombination, and repair]; Region: COG0433
709986004683	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2380
709986004684	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
709986004685	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986004686	active site
709986004687	phosphorylation site [posttranslational modification]
709986004688	intermolecular recognition site; other site
709986004689	dimerization interface [polypeptide binding]; other site
709986004690	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
709986004691	DNA binding residues [nucleotide binding]
709986004692	dimerization interface [polypeptide binding]; other site
709986004693	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
709986004694	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986004695	ATP binding site [chemical binding]; other site
709986004696	Mg2+ binding site [ion binding]; other site
709986004697	G-X-G motif; other site
709986004698	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
709986004699	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
709986004700	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
709986004701	Soluble P-type ATPase [General function prediction only]; Region: COG4087
709986004702	K+-transporting ATPase, c chain; Region: KdpC; cl00944
709986004703	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
709986004704	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
709986004705	dimerization interface [polypeptide binding]; other site
709986004706	putative DNA binding site [nucleotide binding]; other site
709986004707	putative Zn2+ binding site [ion binding]; other site
709986004708	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
709986004709	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
709986004710	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
709986004711	Ligand Binding Site [chemical binding]; other site
709986004712	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
709986004713	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
709986004714	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
709986004715	catalytic residue [active]
709986004716	choline dehydrogenase; Validated; Region: PRK02106
709986004717	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
709986004718	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
709986004719	nitrous-oxide reductase; Validated; Region: PRK02888
709986004720	Predicted integral membrane protein [Function unknown]; Region: COG5637
709986004721	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
709986004722	putative hydrophobic ligand binding site [chemical binding]; other site
709986004723	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
709986004724	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
709986004725	NAD binding site [chemical binding]; other site
709986004726	catalytic Zn binding site [ion binding]; other site
709986004727	structural Zn binding site [ion binding]; other site
709986004728	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
709986004729	AAA domain; Region: AAA_30; pfam13604
709986004730	Family description; Region: UvrD_C_2; pfam13538
709986004731	Transcriptional regulators [Transcription]; Region: PurR; COG1609
709986004732	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
709986004733	DNA binding site [nucleotide binding]
709986004734	domain linker motif; other site
709986004735	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
709986004736	dimerization interface [polypeptide binding]; other site
709986004737	ligand binding site [chemical binding]; other site
709986004738	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
709986004739	active site
709986004740	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
709986004741	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
709986004742	metal ion-dependent adhesion site (MIDAS); other site
709986004743	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
709986004744	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
709986004745	active site
709986004746	metal binding site [ion binding]; metal-binding site
709986004747	DNA binding site [nucleotide binding]
709986004748	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
709986004749	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
709986004750	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
709986004751	Walker A/P-loop; other site
709986004752	ATP binding site [chemical binding]; other site
709986004753	Q-loop/lid; other site
709986004754	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
709986004755	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
709986004756	ABC transporter signature motif; other site
709986004757	Walker B; other site
709986004758	D-loop; other site
709986004759	H-loop/switch region; other site
709986004760	FOG: WD40-like repeat [Function unknown]; Region: COG1520
709986004761	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
709986004762	Trp docking motif [polypeptide binding]; other site
709986004763	active site
709986004764	PQQ-like domain; Region: PQQ_2; pfam13360
709986004765	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
709986004766	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
709986004767	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
709986004768	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
709986004769	Surface antigen; Region: Bac_surface_Ag; pfam01103
709986004770	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
709986004771	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
709986004772	catalytic residue [active]
709986004773	DivIVA protein; Region: DivIVA; pfam05103
709986004774	DivIVA domain; Region: DivI1A_domain; TIGR03544
709986004775	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
709986004776	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
709986004777	non-specific DNA binding site [nucleotide binding]; other site
709986004778	salt bridge; other site
709986004779	sequence-specific DNA binding site [nucleotide binding]; other site
709986004780	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
709986004781	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
709986004782	Walker A/P-loop; other site
709986004783	ATP binding site [chemical binding]; other site
709986004784	Q-loop/lid; other site
709986004785	ABC transporter signature motif; other site
709986004786	Walker B; other site
709986004787	D-loop; other site
709986004788	H-loop/switch region; other site
709986004789	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
709986004790	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
709986004791	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
709986004792	Protein of unknown function (DUF3990); Region: DUF3990; pfam13151
709986004793	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
709986004794	RNA/DNA hybrid binding site [nucleotide binding]; other site
709986004795	active site
709986004796	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
709986004797	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
709986004798	substrate binding pocket [chemical binding]; other site
709986004799	membrane-bound complex binding site; other site
709986004800	hinge residues; other site
709986004801	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
709986004802	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
709986004803	catalytic residues [active]
709986004804	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
709986004805	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
709986004806	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
709986004807	dimer interface [polypeptide binding]; other site
709986004808	active site
709986004809	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
709986004810	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
709986004811	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
709986004812	Walker A/P-loop; other site
709986004813	ATP binding site [chemical binding]; other site
709986004814	Q-loop/lid; other site
709986004815	ABC transporter signature motif; other site
709986004816	Walker B; other site
709986004817	D-loop; other site
709986004818	H-loop/switch region; other site
709986004819	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
709986004820	Predicted membrane protein [Function unknown]; Region: COG2364
709986004821	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
709986004822	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
709986004823	apolar tunnel; other site
709986004824	heme binding site [chemical binding]; other site
709986004825	dimerization interface [polypeptide binding]; other site
709986004826	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
709986004827	Predicted transcriptional regulator [Transcription]; Region: COG2345
709986004828	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
709986004829	dimerization interface [polypeptide binding]; other site
709986004830	putative DNA binding site [nucleotide binding]; other site
709986004831	putative Zn2+ binding site [ion binding]; other site
709986004832	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
709986004833	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
709986004834	GMP synthase; Reviewed; Region: guaA; PRK00074
709986004835	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
709986004836	AMP/PPi binding site [chemical binding]; other site
709986004837	candidate oxyanion hole; other site
709986004838	catalytic triad [active]
709986004839	potential glutamine specificity residues [chemical binding]; other site
709986004840	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
709986004841	ATP Binding subdomain [chemical binding]; other site
709986004842	Ligand Binding sites [chemical binding]; other site
709986004843	Dimerization subdomain; other site
709986004844	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
709986004845	30S subunit binding site; other site
709986004846	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
709986004847	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
709986004848	active site
709986004849	Riboflavin kinase; Region: Flavokinase; pfam01687
709986004850	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
709986004851	dimer interface [polypeptide binding]; other site
709986004852	ADP-ribose binding site [chemical binding]; other site
709986004853	active site
709986004854	nudix motif; other site
709986004855	metal binding site [ion binding]; metal-binding site
709986004856	cell division protein FtsZ; Validated; Region: PRK09330
709986004857	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
709986004858	nucleotide binding site [chemical binding]; other site
709986004859	SulA interaction site; other site
709986004860	cell division protein FtsA; Region: ftsA; TIGR01174
709986004861	Cell division protein FtsA; Region: FtsA; smart00842
709986004862	Cell division protein FtsA; Region: FtsA; pfam14450
709986004863	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
709986004864	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
709986004865	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14651
709986004866	FAD binding domain; Region: FAD_binding_4; pfam01565
709986004867	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
709986004868	UDP-N-acetylmuramate--alanine ligase; Region: murC; TIGR01082
709986004869	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
709986004870	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
709986004871	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
709986004872	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
709986004873	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
709986004874	active site
709986004875	homodimer interface [polypeptide binding]; other site
709986004876	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
709986004877	UDP-N-acetylmuramoylalanine--D-glutamate ligase; Region: murD; TIGR01087
709986004878	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
709986004879	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK14655
709986004880	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
709986004881	Mg++ binding site [ion binding]; other site
709986004882	putative catalytic motif [active]
709986004883	putative substrate binding site [chemical binding]; other site
709986004884	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
709986004885	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
709986004886	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
709986004887	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
709986004888	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
709986004889	TROVE domain; Region: TROVE; pfam05731
709986004890	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
709986004891	DAK2 domain; Region: Dak2; pfam02734
709986004892	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
709986004893	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
709986004894	dinuclear metal binding motif [ion binding]; other site
709986004895	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
709986004896	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
709986004897	MutS domain III; Region: MutS_III; pfam05192
709986004898	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
709986004899	Walker A/P-loop; other site
709986004900	ATP binding site [chemical binding]; other site
709986004901	Q-loop/lid; other site
709986004902	ABC transporter signature motif; other site
709986004903	Walker B; other site
709986004904	D-loop; other site
709986004905	H-loop/switch region; other site
709986004906	Smr domain; Region: Smr; pfam01713
709986004907	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986004908	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986004909	metal binding site [ion binding]; metal-binding site
709986004910	active site
709986004911	I-site; other site
709986004912	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
709986004913	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14468
709986004914	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
709986004915	FeS/SAM binding site; other site
709986004916	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
709986004917	TPR motif; other site
709986004918	TPR repeat; Region: TPR_11; pfam13414
709986004919	binding surface
709986004920	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
709986004921	TPR motif; other site
709986004922	TPR repeat; Region: TPR_11; pfam13414
709986004923	binding surface
709986004924	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
709986004925	TPR motif; other site
709986004926	binding surface
709986004927	Sporulation related domain; Region: SPOR; pfam05036
709986004928	Sporulation related domain; Region: SPOR; pfam05036
709986004929	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
709986004930	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
709986004931	CoA binding domain; Region: CoA_binding; pfam02629
709986004932	Protein of unknown function (DUF970); Region: DUF970; cl17525
709986004933	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
709986004934	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
709986004935	Domain of unknown function (DUF814); Region: DUF814; pfam05670
709986004936	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
709986004937	tetramerization interface [polypeptide binding]; other site
709986004938	active site
709986004939	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
709986004940	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
709986004941	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
709986004942	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
709986004943	NAD binding site [chemical binding]; other site
709986004944	4-alpha-glucanotransferase; Provisional; Region: PRK14508
709986004945	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
709986004946	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
709986004947	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
709986004948	active site
709986004949	metal binding site [ion binding]; metal-binding site
709986004950	OstA-like protein; Region: OstA; cl00844
709986004951	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
709986004952	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
709986004953	EDD domain protein, DegV family; Region: DegV; TIGR00762
709986004954	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
709986004955	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
709986004956	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
709986004957	active site
709986004958	aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159
709986004959	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
709986004960	Dimer interface [polypeptide binding]; other site
709986004961	anticodon binding site; other site
709986004962	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
709986004963	motif 1; other site
709986004964	dimer interface [polypeptide binding]; other site
709986004965	active site
709986004966	motif 2; other site
709986004967	motif 3; other site
709986004968	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
709986004969	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
709986004970	HicB family; Region: HicB; pfam05534
709986004971	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
709986004972	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
709986004973	Walker A/P-loop; other site
709986004974	ATP binding site [chemical binding]; other site
709986004975	Q-loop/lid; other site
709986004976	ABC transporter signature motif; other site
709986004977	Walker B; other site
709986004978	D-loop; other site
709986004979	H-loop/switch region; other site
709986004980	Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250
709986004981	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
709986004982	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
709986004983	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
709986004984	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
709986004985	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
709986004986	Peptidase M16C associated; Region: M16C_assoc; pfam08367
709986004987	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
709986004988	Putative Ig domain; Region: He_PIG; pfam05345
709986004989	Uncharacterized protein conserved in archaea (DUF2067); Region: DUF2067; cl01288
709986004990	S4 domain; Region: S4_2; pfam13275
709986004991	Protein of unknown function (DUF1684); Region: DUF1684; pfam07920
709986004992	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
709986004993	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
709986004994	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
709986004995	DNA-binding site [nucleotide binding]; DNA binding site
709986004996	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
709986004997	pyridoxal 5'-phosphate binding site [chemical binding]; other site
709986004998	homodimer interface [polypeptide binding]; other site
709986004999	catalytic residue [active]
709986005000	short chain dehydrogenase; Provisional; Region: PRK07825
709986005001	classical (c) SDRs; Region: SDR_c; cd05233
709986005002	NAD(P) binding site [chemical binding]; other site
709986005003	active site
709986005004	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
709986005005	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
709986005006	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
709986005007	putative RNA binding site [nucleotide binding]; other site
709986005008	S-adenosylmethionine binding site [chemical binding]; other site
709986005009	Methyltransferase domain; Region: Methyltransf_26; pfam13659
709986005010	spore photoproduct lyase family protein; Region: lyase_spl_fam; TIGR03886
709986005011	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
709986005012	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
709986005013	classical (c) SDRs; Region: SDR_c; cd05233
709986005014	NAD(P) binding site [chemical binding]; other site
709986005015	active site
709986005016	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
709986005017	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
709986005018	catalytic triad [active]
709986005019	cyanophycin synthetase; Provisional; Region: PRK14016
709986005020	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
709986005021	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
709986005022	Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and  L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635
709986005023	active site
709986005024	dimer interface [polypeptide binding]; other site
709986005025	catalytic nucleophile [active]
709986005026	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
709986005027	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
709986005028	Ligand Binding Site [chemical binding]; other site
709986005029	TilS substrate C-terminal domain; Region: TilS_C; smart00977
709986005030	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
709986005031	nucleoside/Zn binding site; other site
709986005032	dimer interface [polypeptide binding]; other site
709986005033	catalytic motif [active]
709986005034	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
709986005035	classical (c) SDRs; Region: SDR_c; cd05233
709986005036	NAD(P) binding site [chemical binding]; other site
709986005037	active site
709986005038	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
709986005039	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
709986005040	motif II; other site
709986005041	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
709986005042	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
709986005043	putative ATP binding site [chemical binding]; other site
709986005044	Uncharacterized conserved protein, YhbC family [Function unknown]; Region: COG0782
709986005045	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
709986005046	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
709986005047	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986005048	dimer interface [polypeptide binding]; other site
709986005049	conserved gate region; other site
709986005050	putative PBP binding loops; other site
709986005051	ABC-ATPase subunit interface; other site
709986005052	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986005053	dimer interface [polypeptide binding]; other site
709986005054	conserved gate region; other site
709986005055	putative PBP binding loops; other site
709986005056	ABC-ATPase subunit interface; other site
709986005057	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
709986005058	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
709986005059	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
709986005060	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
709986005061	Protein of unknown function (DUF3293); Region: DUF3293; pfam11697
709986005062	tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142
709986005063	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
709986005064	Permutation of conserved domain; other site
709986005065	active site
709986005066	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
709986005067	GAF domain; Region: GAF; cl17456
709986005068	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
709986005069	PAS domain S-box; Region: sensory_box; TIGR00229
709986005070	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986005071	putative active site [active]
709986005072	heme pocket [chemical binding]; other site
709986005073	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986005074	metal binding site [ion binding]; metal-binding site
709986005075	active site
709986005076	I-site; other site
709986005077	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
709986005078	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
709986005079	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
709986005080	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986005081	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986005082	metal binding site [ion binding]; metal-binding site
709986005083	active site
709986005084	I-site; other site
709986005085	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986005086	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986005087	metal binding site [ion binding]; metal-binding site
709986005088	active site
709986005089	I-site; other site
709986005090	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
709986005091	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
709986005092	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
709986005093	FeoA domain; Region: FeoA; pfam04023
709986005094	PAS domain S-box; Region: sensory_box; TIGR00229
709986005095	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986005096	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986005097	metal binding site [ion binding]; metal-binding site
709986005098	active site
709986005099	I-site; other site
709986005100	GAF domain; Region: GAF_3; pfam13492
709986005101	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
709986005102	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
709986005103	Zn2+ binding site [ion binding]; other site
709986005104	Mg2+ binding site [ion binding]; other site
709986005105	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
709986005106	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986005107	PAS domain; Region: PAS_9; pfam13426
709986005108	putative active site [active]
709986005109	heme pocket [chemical binding]; other site
709986005110	PAS fold; Region: PAS_4; pfam08448
709986005111	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986005112	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986005113	metal binding site [ion binding]; metal-binding site
709986005114	active site
709986005115	I-site; other site
709986005116	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
709986005117	Major Facilitator Superfamily; Region: MFS_1; pfam07690
709986005118	putative substrate translocation pore; other site
709986005119	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
709986005120	Transcriptional regulators [Transcription]; Region: MarR; COG1846
709986005121	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
709986005122	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
709986005123	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
709986005124	Zn binding site [ion binding]; other site
709986005125	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
709986005126	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
709986005127	Zn binding site [ion binding]; other site
709986005128	Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098
709986005129	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
709986005130	RNA binding site [nucleotide binding]; other site
709986005131	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
709986005132	active site
709986005133	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
709986005134	active site
709986005135	ribulose/triose binding site [chemical binding]; other site
709986005136	phosphate binding site [ion binding]; other site
709986005137	substrate (anthranilate) binding pocket [chemical binding]; other site
709986005138	product (indole) binding pocket [chemical binding]; other site
709986005139	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
709986005140	putative hydrolase; Provisional; Region: PRK02113
709986005141	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
709986005142	Thioredoxin; Region: Thioredoxin_4; pfam13462
709986005143	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
709986005144	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
709986005145	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
709986005146	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
709986005147	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
709986005148	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
709986005149	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
709986005150	Coenzyme A binding pocket [chemical binding]; other site
709986005151	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
709986005152	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
709986005153	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
709986005154	Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
709986005155	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
709986005156	active site
709986005157	PrcB C-terminal; Region: PrcB_C; pfam14343
709986005158	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
709986005159	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
709986005160	Walker A/P-loop; other site
709986005161	ATP binding site [chemical binding]; other site
709986005162	Q-loop/lid; other site
709986005163	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
709986005164	ABC transporter signature motif; other site
709986005165	Walker B; other site
709986005166	D-loop; other site
709986005167	H-loop/switch region; other site
709986005168	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
709986005169	PRC-barrel domain; Region: PRC; pfam05239
709986005170	PRC-barrel domain; Region: PRC; pfam05239
709986005171	hypothetical protein; Provisional; Region: PRK01184
709986005172	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
709986005173	Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and residues that can...; Region: MLE_like; cd03315
709986005174	active site
709986005175	aconitate hydratase; Validated; Region: PRK09277
709986005176	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
709986005177	substrate binding site [chemical binding]; other site
709986005178	ligand binding site [chemical binding]; other site
709986005179	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
709986005180	substrate binding site [chemical binding]; other site
709986005181	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
709986005182	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
709986005183	VanW like protein; Region: VanW; pfam04294
709986005184	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
709986005185	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
709986005186	active site
709986005187	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
709986005188	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
709986005189	ligand binding site [chemical binding]; other site
709986005190	flexible hinge region; other site
709986005191	helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419
709986005192	non-specific DNA interactions [nucleotide binding]; other site
709986005193	DNA binding site [nucleotide binding]
709986005194	sequence specific DNA binding site [nucleotide binding]; other site
709986005195	putative cAMP binding site [chemical binding]; other site
709986005196	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
709986005197	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
709986005198	Walker A/P-loop; other site
709986005199	ATP binding site [chemical binding]; other site
709986005200	Q-loop/lid; other site
709986005201	ABC transporter signature motif; other site
709986005202	Walker B; other site
709986005203	D-loop; other site
709986005204	H-loop/switch region; other site
709986005205	S-layer homology domain; Region: SLH; pfam00395
709986005206	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
709986005207	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
709986005208	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
709986005209	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
709986005210	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
709986005211	substrate binding site [chemical binding]; other site
709986005212	oxyanion hole (OAH) forming residues; other site
709986005213	trimer interface [polypeptide binding]; other site
709986005214	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
709986005215	HD supefamily hydrolase [General function prediction only]; Region: COG3294
709986005216	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
709986005217	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680
709986005218	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
709986005219	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
709986005220	G1 box; other site
709986005221	putative GEF interaction site [polypeptide binding]; other site
709986005222	GTP/Mg2+ binding site [chemical binding]; other site
709986005223	Switch I region; other site
709986005224	G2 box; other site
709986005225	G3 box; other site
709986005226	Switch II region; other site
709986005227	G4 box; other site
709986005228	G5 box; other site
709986005229	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
709986005230	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
709986005231	hypothetical protein; Provisional; Region: PRK01842
709986005232	SEC-C motif; Region: SEC-C; pfam02810
709986005233	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
709986005234	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
709986005235	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
709986005236	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
709986005237	ligand binding site; other site
709986005238	oligomer interface; other site
709986005239	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
709986005240	dimer interface [polypeptide binding]; other site
709986005241	N-terminal domain interface [polypeptide binding]; other site
709986005242	sulfate 1 binding site; other site
709986005243	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
709986005244	hypothetical protein; Provisional; Region: PRK10621
709986005245	methionine sulfoxide reductase A; Provisional; Region: PRK14054
709986005246	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
709986005247	MOSC domain; Region: MOSC; pfam03473
709986005248	3-alpha domain; Region: 3-alpha; pfam03475
709986005249	tellurite resistance protein terB; Region: terB; cd07176
709986005250	putative metal binding site [ion binding]; other site
709986005251	ERF superfamily; Region: ERF; pfam04404
709986005252	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
709986005253	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
709986005254	HIGH motif; other site
709986005255	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
709986005256	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
709986005257	active site
709986005258	KMSKS motif; other site
709986005259	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
709986005260	tRNA binding surface [nucleotide binding]; other site
709986005261	putative acetyltransferase; Provisional; Region: PRK03624
709986005262	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
709986005263	Coenzyme A binding pocket [chemical binding]; other site
709986005264	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
709986005265	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
709986005266	active site
709986005267	substrate-binding site [chemical binding]; other site
709986005268	metal-binding site [ion binding]
709986005269	ATP binding site [chemical binding]; other site
709986005270	Uncharacterized conserved protein [Function unknown]; Region: COG4278
709986005271	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
709986005272	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
709986005273	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
709986005274	trehalose synthase; Region: treS_nterm; TIGR02456
709986005275	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
709986005276	active site
709986005277	catalytic site [active]
709986005278	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
709986005279	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
709986005280	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
709986005281	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
709986005282	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
709986005283	active site
709986005284	catalytic site [active]
709986005285	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
709986005286	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
709986005287	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
709986005288	catalytic site [active]
709986005289	active site
709986005290	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
709986005291	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
709986005292	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
709986005293	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
709986005294	active site
709986005295	catalytic site [active]
709986005296	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
709986005297	NMT1-like family; Region: NMT1_2; pfam13379
709986005298	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
709986005299	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
709986005300	S-adenosylmethionine binding site [chemical binding]; other site
709986005301	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
709986005302	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
709986005303	active site
709986005304	HIGH motif; other site
709986005305	nucleotide binding site [chemical binding]; other site
709986005306	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
709986005307	active site
709986005308	KMSKS motif; other site
709986005309	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
709986005310	tRNA binding surface [nucleotide binding]; other site
709986005311	anticodon binding site; other site
709986005312	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
709986005313	active site
709986005314	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
709986005315	active site
709986005316	intersubunit interactions; other site
709986005317	catalytic residue [active]
709986005318	transcription termination factor Rho; Provisional; Region: rho; PRK09376
709986005319	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
709986005320	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
709986005321	RNA binding site [nucleotide binding]; other site
709986005322	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
709986005323	Walker A motif; other site
709986005324	ATP binding site [chemical binding]; other site
709986005325	Walker B motif; other site
709986005326	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
709986005327	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
709986005328	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
709986005329	Peptidase family M23; Region: Peptidase_M23; pfam01551
709986005330	Response regulator receiver domain; Region: Response_reg; pfam00072
709986005331	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986005332	active site
709986005333	phosphorylation site [posttranslational modification]
709986005334	intermolecular recognition site; other site
709986005335	dimerization interface [polypeptide binding]; other site
709986005336	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
709986005337	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
709986005338	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
709986005339	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
709986005340	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
709986005341	active site
709986005342	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
709986005343	triosephosphate isomerase; Provisional; Region: PRK14565
709986005344	substrate binding site [chemical binding]; other site
709986005345	dimer interface [polypeptide binding]; other site
709986005346	catalytic triad [active]
709986005347	Phosphoglycerate kinase; Region: PGK; pfam00162
709986005348	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
709986005349	substrate binding site [chemical binding]; other site
709986005350	hinge regions; other site
709986005351	ADP binding site [chemical binding]; other site
709986005352	catalytic site [active]
709986005353	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
709986005354	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
709986005355	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
709986005356	Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845
709986005357	Chloramphenicol acetyltransferase; Region: CAT; smart01059
709986005358	aspartate kinase; Provisional; Region: PRK06291
709986005359	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
709986005360	nucleotide binding site [chemical binding]; other site
709986005361	substrate binding site [chemical binding]; other site
709986005362	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
709986005363	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
709986005364	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
709986005365	active site
709986005366	motif I; other site
709986005367	motif II; other site
709986005368	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
709986005369	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
709986005370	Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567
709986005371	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
709986005372	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
709986005373	dimer interface [polypeptide binding]; other site
709986005374	anticodon binding site; other site
709986005375	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
709986005376	homodimer interface [polypeptide binding]; other site
709986005377	motif 1; other site
709986005378	active site
709986005379	motif 2; other site
709986005380	GAD domain; Region: GAD; pfam02938
709986005381	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
709986005382	active site
709986005383	motif 3; other site
709986005384	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
709986005385	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
709986005386	dimer interface [polypeptide binding]; other site
709986005387	motif 1; other site
709986005388	active site
709986005389	motif 2; other site
709986005390	motif 3; other site
709986005391	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
709986005392	anticodon binding site; other site
709986005393	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
709986005394	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
709986005395	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
709986005396	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
709986005397	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
709986005398	active site
709986005399	catalytic residues [active]
709986005400	DNA binding site [nucleotide binding]
709986005401	Int/Topo IB signature motif; other site
709986005402	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
709986005403	IHF - DNA interface [nucleotide binding]; other site
709986005404	IHF dimer interface [polypeptide binding]; other site
709986005405	Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936
709986005406	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
709986005407	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
709986005408	Walker A/P-loop; other site
709986005409	ATP binding site [chemical binding]; other site
709986005410	Q-loop/lid; other site
709986005411	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
709986005412	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
709986005413	ABC transporter signature motif; other site
709986005414	Walker B; other site
709986005415	D-loop; other site
709986005416	H-loop/switch region; other site
709986005417	Sporulation and spore germination; Region: Germane; pfam10646
709986005418	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
709986005419	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
709986005420	active site
709986005421	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
709986005422	SmpB-tmRNA interface; other site
709986005423	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
709986005424	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
709986005425	putative dimer interface [polypeptide binding]; other site
709986005426	putative anticodon binding site; other site
709986005427	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
709986005428	homodimer interface [polypeptide binding]; other site
709986005429	motif 1; other site
709986005430	motif 2; other site
709986005431	active site
709986005432	motif 3; other site
709986005433	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
709986005434	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
709986005435	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
709986005436	putative active site [active]
709986005437	catalytic triad [active]
709986005438	putative dimer interface [polypeptide binding]; other site
709986005439	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
709986005440	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
709986005441	active site
709986005442	metal binding site [ion binding]; metal-binding site
709986005443	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
709986005444	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
709986005445	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
709986005446	homodimer interface [polypeptide binding]; other site
709986005447	pyridoxal 5'-phosphate binding site [chemical binding]; other site
709986005448	catalytic residue [active]
709986005449	AAA domain; Region: AAA_18; pfam13238
709986005450	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
709986005451	active site
709986005452	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
709986005453	propionate/acetate kinase; Provisional; Region: PRK12379
709986005454	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
709986005455	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
709986005456	dimerization interface [polypeptide binding]; other site
709986005457	metal binding site [ion binding]; metal-binding site
709986005458	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
709986005459	substrate binding site [chemical binding]; other site
709986005460	active site
709986005461	catalytic residues [active]
709986005462	heterodimer interface [polypeptide binding]; other site
709986005463	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
709986005464	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
709986005465	pyridoxal 5'-phosphate binding site [chemical binding]; other site
709986005466	catalytic residue [active]
709986005467	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
709986005468	active site
709986005469	HIGH motif; other site
709986005470	nucleotide binding site [chemical binding]; other site
709986005471	active site
709986005472	KMSKS motif; other site
709986005473	PAS fold; Region: PAS_3; pfam08447
709986005474	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986005475	heme pocket [chemical binding]; other site
709986005476	putative active site [active]
709986005477	GAF domain; Region: GAF_3; pfam13492
709986005478	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
709986005479	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
709986005480	dimer interface [polypeptide binding]; other site
709986005481	phosphorylation site [posttranslational modification]
709986005482	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986005483	ATP binding site [chemical binding]; other site
709986005484	Mg2+ binding site [ion binding]; other site
709986005485	G-X-G motif; other site
709986005486	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
709986005487	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
709986005488	active site
709986005489	catalytic site [active]
709986005490	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
709986005491	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
709986005492	motif II; other site
709986005493	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
709986005494	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
709986005495	active site
709986005496	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
709986005497	NlpC/P60 family; Region: NLPC_P60; pfam00877
709986005498	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
709986005499	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
709986005500	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
709986005501	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
709986005502	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
709986005503	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
709986005504	Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015
709986005505	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
709986005506	Tetratricopeptide repeat; Region: TPR_12; pfam13424
709986005507	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
709986005508	binding surface
709986005509	TPR motif; other site
709986005510	Tetratricopeptide repeat; Region: TPR_12; pfam13424
709986005511	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986005512	metal binding site [ion binding]; metal-binding site
709986005513	active site
709986005514	I-site; other site
709986005515	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
709986005516	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
709986005517	active site
709986005518	catalytic residues [active]
709986005519	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
709986005520	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
709986005521	GIY-YIG motif/motif A; other site
709986005522	active site
709986005523	catalytic site [active]
709986005524	putative DNA binding site [nucleotide binding]; other site
709986005525	metal binding site [ion binding]; metal-binding site
709986005526	UvrB/uvrC motif; Region: UVR; pfam02151
709986005527	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
709986005528	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
709986005529	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
709986005530	putative lipid kinase; Reviewed; Region: PRK13057
709986005531	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465
709986005532	oligoendopeptidase F; Region: pepF; TIGR00181
709986005533	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
709986005534	active site
709986005535	Zn binding site [ion binding]; other site
709986005536	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
709986005537	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
709986005538	catalytic site [active]
709986005539	PGAP1-like protein; Region: PGAP1; pfam07819
709986005540	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
709986005541	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
709986005542	catalytic site [active]
709986005543	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
709986005544	predicted active site [active]
709986005545	catalytic triad [active]
709986005546	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
709986005547	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
709986005548	active site
709986005549	multimer interface [polypeptide binding]; other site
709986005550	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
709986005551	Tetratricopeptide repeat; Region: TPR_12; pfam13424
709986005552	Tetratricopeptide repeat; Region: TPR_12; pfam13424
709986005553	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
709986005554	binding surface
709986005555	TPR motif; other site
709986005556	Cdc37 N terminal kinase binding; Region: CDC37_N; cl03951
709986005557	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986005558	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986005559	metal binding site [ion binding]; metal-binding site
709986005560	active site
709986005561	I-site; other site
709986005562	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
709986005563	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
709986005564	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
709986005565	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
709986005566	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
709986005567	NAD binding site [chemical binding]; other site
709986005568	catalytic residues [active]
709986005569	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309
709986005570	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
709986005571	3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295
709986005572	N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266
709986005573	tetramer interface [polypeptide binding]; other site
709986005574	C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256
709986005575	tetramer interface [polypeptide binding]; other site
709986005576	active site
709986005577	metal binding site [ion binding]; metal-binding site
709986005578	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
709986005579	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
709986005580	NAD(P) binding site [chemical binding]; other site
709986005581	catalytic residues [active]
709986005582	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
709986005583	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
709986005584	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
709986005585	tRNA dimethylallyltransferase; Region: miaA; TIGR00174
709986005586	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
709986005587	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
709986005588	putative dimer interface [polypeptide binding]; other site
709986005589	Major Facilitator Superfamily; Region: MFS_1; pfam07690
709986005590	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
709986005591	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
709986005592	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
709986005593	MoxR-like ATPases [General function prediction only]; Region: COG0714
709986005594	Walker A motif; other site
709986005595	ATP binding site [chemical binding]; other site
709986005596	Walker B motif; other site
709986005597	arginine finger; other site
709986005598	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864
709986005599	Putative metallopeptidase domain; Region: DUF2201_N; pfam13203
709986005600	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
709986005601	Transcriptional regulators [Transcription]; Region: PurR; COG1609
709986005602	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
709986005603	DNA binding site [nucleotide binding]
709986005604	domain linker motif; other site
709986005605	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_9; cd06290
709986005606	putative dimerization interface [polypeptide binding]; other site
709986005607	putative ligand binding site [chemical binding]; other site
709986005608	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
709986005609	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
709986005610	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
709986005611	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986005612	dimer interface [polypeptide binding]; other site
709986005613	conserved gate region; other site
709986005614	putative PBP binding loops; other site
709986005615	ABC-ATPase subunit interface; other site
709986005616	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
709986005617	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986005618	dimer interface [polypeptide binding]; other site
709986005619	conserved gate region; other site
709986005620	putative PBP binding loops; other site
709986005621	ABC-ATPase subunit interface; other site
709986005622	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
709986005623	beta-galactosidase; Region: BGL; TIGR03356
709986005624	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
709986005625	active site
709986005626	catalytic residues [active]
709986005627	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
709986005628	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
709986005629	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
709986005630	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
709986005631	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
709986005632	purine monophosphate binding site [chemical binding]; other site
709986005633	dimer interface [polypeptide binding]; other site
709986005634	putative catalytic residues [active]
709986005635	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
709986005636	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
709986005637	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
709986005638	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
709986005639	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
709986005640	homodimer interface [polypeptide binding]; other site
709986005641	NADP binding site [chemical binding]; other site
709986005642	substrate binding site [chemical binding]; other site
709986005643	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
709986005644	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
709986005645	Walker A/P-loop; other site
709986005646	ATP binding site [chemical binding]; other site
709986005647	Q-loop/lid; other site
709986005648	ABC transporter signature motif; other site
709986005649	Walker B; other site
709986005650	D-loop; other site
709986005651	H-loop/switch region; other site
709986005652	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986005653	dimer interface [polypeptide binding]; other site
709986005654	conserved gate region; other site
709986005655	putative PBP binding loops; other site
709986005656	ABC-ATPase subunit interface; other site
709986005657	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
709986005658	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986005659	dimer interface [polypeptide binding]; other site
709986005660	conserved gate region; other site
709986005661	putative PBP binding loops; other site
709986005662	ABC-ATPase subunit interface; other site
709986005663	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
709986005664	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
709986005665	substrate binding pocket [chemical binding]; other site
709986005666	membrane-bound complex binding site; other site
709986005667	hinge residues; other site
709986005668	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
709986005669	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986005670	dimer interface [polypeptide binding]; other site
709986005671	conserved gate region; other site
709986005672	putative PBP binding loops; other site
709986005673	ABC-ATPase subunit interface; other site
709986005674	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
709986005675	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
709986005676	substrate binding pocket [chemical binding]; other site
709986005677	membrane-bound complex binding site; other site
709986005678	hinge residues; other site
709986005679	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
709986005680	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
709986005681	Walker A/P-loop; other site
709986005682	ATP binding site [chemical binding]; other site
709986005683	Q-loop/lid; other site
709986005684	ABC transporter signature motif; other site
709986005685	Walker B; other site
709986005686	D-loop; other site
709986005687	H-loop/switch region; other site
709986005688	TOBE domain; Region: TOBE_2; pfam08402
709986005689	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
709986005690	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
709986005691	UGMP family protein; Validated; Region: PRK09604
709986005692	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
709986005693	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048
709986005694	RNAase interaction site [polypeptide binding]; other site
709986005695	microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th,  Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212
709986005696	active site
709986005697	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
709986005698	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
709986005699	active site
709986005700	P-loop; other site
709986005701	phosphorylation site [posttranslational modification]
709986005702	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
709986005703	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
709986005704	active site
709986005705	P-loop; other site
709986005706	phosphorylation site [posttranslational modification]
709986005707	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
709986005708	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
709986005709	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
709986005710	putative substrate binding site [chemical binding]; other site
709986005711	putative ATP binding site [chemical binding]; other site
709986005712	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
709986005713	active site
709986005714	phosphorylation site [posttranslational modification]
709986005715	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
709986005716	dimerization domain swap beta strand [polypeptide binding]; other site
709986005717	regulatory protein interface [polypeptide binding]; other site
709986005718	active site
709986005719	regulatory phosphorylation site [posttranslational modification]; other site
709986005720	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
709986005721	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
709986005722	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
709986005723	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
709986005724	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
709986005725	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
709986005726	putative DNA binding site [nucleotide binding]; other site
709986005727	putative Zn2+ binding site [ion binding]; other site
709986005728	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
709986005729	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986005730	PAS domain; Region: PAS_9; pfam13426
709986005731	putative active site [active]
709986005732	heme pocket [chemical binding]; other site
709986005733	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986005734	ATP binding site [chemical binding]; other site
709986005735	Mg2+ binding site [ion binding]; other site
709986005736	G-X-G motif; other site
709986005737	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
709986005738	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
709986005739	Part of AAA domain; Region: AAA_19; pfam13245
709986005740	Family description; Region: UvrD_C_2; pfam13538
709986005741	Ferritin-like domain; Region: Ferritin_2; pfam13668
709986005742	Rrf2 family protein; Region: rrf2_super; TIGR00738
709986005743	Transcriptional regulator; Region: Rrf2; pfam02082
709986005744	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
709986005745	Cytochrome P450; Region: p450; cl12078
709986005746	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
709986005747	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
709986005748	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
709986005749	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
709986005750	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
709986005751	ligand-binding site [chemical binding]; other site
709986005752	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
709986005753	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
709986005754	Active Sites [active]
709986005755	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
709986005756	ATP-sulfurylase; Region: ATPS; cd00517
709986005757	active site
709986005758	HXXH motif; other site
709986005759	flexible loop; other site
709986005760	NMT1-like family; Region: NMT1_2; pfam13379
709986005761	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
709986005762	substrate binding pocket [chemical binding]; other site
709986005763	membrane-bound complex binding site; other site
709986005764	hinge residues; other site
709986005765	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
709986005766	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986005767	dimer interface [polypeptide binding]; other site
709986005768	conserved gate region; other site
709986005769	putative PBP binding loops; other site
709986005770	ABC-ATPase subunit interface; other site
709986005771	ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840
709986005772	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
709986005773	Walker A/P-loop; other site
709986005774	ATP binding site [chemical binding]; other site
709986005775	Q-loop/lid; other site
709986005776	ABC transporter signature motif; other site
709986005777	Walker B; other site
709986005778	D-loop; other site
709986005779	H-loop/switch region; other site
709986005780	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
709986005781	synthetase active site [active]
709986005782	NTP binding site [chemical binding]; other site
709986005783	metal binding site [ion binding]; metal-binding site
709986005784	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
709986005785	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
709986005786	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
709986005787	substrate binding pocket [chemical binding]; other site
709986005788	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
709986005789	B12 binding site [chemical binding]; other site
709986005790	cobalt ligand [ion binding]; other site
709986005791	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
709986005792	5,10-methylenetetrahydrofolate reductase [Amino acid transport and metabolism]; Region: MetF; COG0685
709986005793	FAD binding site [chemical binding]; other site
709986005794	RNA 2'-phosphotransferase; Reviewed; Region: PRK00819
709986005795	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
709986005796	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
709986005797	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
709986005798	active site
709986005799	HIGH motif; other site
709986005800	KMSK motif region; other site
709986005801	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
709986005802	tRNA binding surface [nucleotide binding]; other site
709986005803	anticodon binding site; other site
709986005804	Divergent PAP2 family; Region: DUF212; pfam02681
709986005805	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
709986005806	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
709986005807	homodimer interface [polypeptide binding]; other site
709986005808	NADP binding site [chemical binding]; other site
709986005809	substrate binding site [chemical binding]; other site
709986005810	transcription antitermination factor NusB; Region: nusB; TIGR01951
709986005811	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
709986005812	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
709986005813	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
709986005814	nucleotide binding pocket [chemical binding]; other site
709986005815	K-X-D-G motif; other site
709986005816	catalytic site [active]
709986005817	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
709986005818	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
709986005819	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
709986005820	Dimer interface [polypeptide binding]; other site
709986005821	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
709986005822	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
709986005823	ligand binding site [chemical binding]; other site
709986005824	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
709986005825	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
709986005826	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
709986005827	NAD(P) binding pocket [chemical binding]; other site
709986005828	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
709986005829	active site
709986005830	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
709986005831	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
709986005832	Walker A/P-loop; other site
709986005833	ATP binding site [chemical binding]; other site
709986005834	Q-loop/lid; other site
709986005835	ABC transporter signature motif; other site
709986005836	Walker B; other site
709986005837	D-loop; other site
709986005838	H-loop/switch region; other site
709986005839	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
709986005840	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
709986005841	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
709986005842	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
709986005843	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
709986005844	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
709986005845	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
709986005846	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
709986005847	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
709986005848	active site
709986005849	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
709986005850	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
709986005851	active site
709986005852	FMN binding site [chemical binding]; other site
709986005853	substrate binding site [chemical binding]; other site
709986005854	3Fe-4S cluster binding site [ion binding]; other site
709986005855	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
709986005856	domain_subunit interface; other site
709986005857	oxidoreductase; Provisional; Region: PRK06196
709986005858	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
709986005859	putative NAD(P) binding site [chemical binding]; other site
709986005860	active site
709986005861	Uncharacterized conserved protein [Function unknown]; Region: COG3603
709986005862	Family description; Region: ACT_7; pfam13840
709986005863	prephenate dehydrogenase; Validated; Region: PRK06545
709986005864	prephenate dehydrogenase; Validated; Region: PRK08507
709986005865	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
709986005866	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
709986005867	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
709986005868	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
709986005869	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
709986005870	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
709986005871	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
709986005872	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
709986005873	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
709986005874	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
709986005875	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
709986005876	motif II; other site
709986005877	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
709986005878	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
709986005879	short chain dehydrogenase; Provisional; Region: PRK08219
709986005880	NAD(P) binding site [chemical binding]; other site
709986005881	active site
709986005882	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217
709986005883	metal binding sites [ion binding]; metal-binding site
709986005884	dimer interface [polypeptide binding]; other site
709986005885	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
709986005886	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
709986005887	active site
709986005888	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
709986005889	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
709986005890	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
709986005891	generic binding surface I; other site
709986005892	generic binding surface II; other site
709986005893	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
709986005894	putative active site [active]
709986005895	putative catalytic site [active]
709986005896	putative Mg binding site IVb [ion binding]; other site
709986005897	putative phosphate binding site [ion binding]; other site
709986005898	putative DNA binding site [nucleotide binding]; other site
709986005899	putative Mg binding site IVa [ion binding]; other site
709986005900	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
709986005901	active site
709986005902	metal-binding site [ion binding]
709986005903	nucleotide-binding site [chemical binding]; other site
709986005904	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
709986005905	GAF domain; Region: GAF; pfam01590
709986005906	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
709986005907	glycosyltransferase, MGT family; Region: MGT; TIGR01426
709986005908	active site
709986005909	TDP-binding site; other site
709986005910	acceptor substrate-binding pocket; other site
709986005911	homodimer interface [polypeptide binding]; other site
709986005912	Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471
709986005913	4-aminobutyrate aminotransferase; Provisional; Region: PRK05769
709986005914	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
709986005915	inhibitor-cofactor binding pocket; inhibition site
709986005916	pyridoxal 5'-phosphate binding site [chemical binding]; other site
709986005917	catalytic residue [active]
709986005918	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
709986005919	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
709986005920	FeS/SAM binding site; other site
709986005921	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
709986005922	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
709986005923	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
709986005924	putative DNA binding site [nucleotide binding]; other site
709986005925	putative Zn2+ binding site [ion binding]; other site
709986005926	AsnC family; Region: AsnC_trans_reg; pfam01037
709986005927	Putative esterase; Region: Esterase; pfam00756
709986005928	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
709986005929	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
709986005930	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
709986005931	Glutamate binding site [chemical binding]; other site
709986005932	homodimer interface [polypeptide binding]; other site
709986005933	NAD binding site [chemical binding]; other site
709986005934	catalytic residues [active]
709986005935	DinB superfamily; Region: DinB_2; pfam12867
709986005936	hypothetical protein; Provisional; Region: PRK07483
709986005937	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
709986005938	inhibitor-cofactor binding pocket; inhibition site
709986005939	pyridoxal 5'-phosphate binding site [chemical binding]; other site
709986005940	catalytic residue [active]
709986005941	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
709986005942	2-phosphosulfolactate phosphatase; Provisional; Region: PRK14100
709986005943	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895
709986005944	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
709986005945	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
709986005946	ligand binding site [chemical binding]; other site
709986005947	flexible hinge region; other site
709986005948	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
709986005949	putative switch regulator; other site
709986005950	non-specific DNA interactions [nucleotide binding]; other site
709986005951	DNA binding site [nucleotide binding]
709986005952	sequence specific DNA binding site [nucleotide binding]; other site
709986005953	putative cAMP binding site [chemical binding]; other site
709986005954	bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998
709986005955	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
709986005956	TrkA-C domain; Region: TrkA_C; pfam02080
709986005957	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
709986005958	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
709986005959	4Fe-4S binding domain; Region: Fer4; cl02805
709986005960	Cysteine-rich domain; Region: CCG; pfam02754
709986005961	Cysteine-rich domain; Region: CCG; pfam02754
709986005962	acylphosphatase; Provisional; Region: PRK14433
709986005963	Family of unknown function (DUF490); Region: DUF490; pfam04357
709986005964	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
709986005965	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
709986005966	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
709986005967	ABC transporter; Region: ABC_tran_2; pfam12848
709986005968	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
709986005969	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
709986005970	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
709986005971	CoA-ligase; Region: Ligase_CoA; pfam00549
709986005972	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
709986005973	CoA binding domain; Region: CoA_binding; smart00881
709986005974	CoA-ligase; Region: Ligase_CoA; pfam00549
709986005975	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
709986005976	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
709986005977	Cupin domain; Region: Cupin_2; pfam07883
709986005978	Transcriptional regulators [Transcription]; Region: MarR; COG1846
709986005979	MarR family; Region: MarR_2; pfam12802
709986005980	EDD domain protein, DegV family; Region: DegV; TIGR00762
709986005981	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
709986005982	RecX family; Region: RecX; cl00936
709986005983	Predicted phosphohydrolase [General function prediction only]; Region: COG1768
709986005984	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
709986005985	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
709986005986	Prephenate dehydratase; Region: PDT; pfam00800
709986005987	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
709986005988	putative L-Phe binding site [chemical binding]; other site
709986005989	amidase; Provisional; Region: PRK08137
709986005990	Amidase; Region: Amidase; cl11426
709986005991	PAS domain S-box; Region: sensory_box; TIGR00229
709986005992	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986005993	putative active site [active]
709986005994	heme pocket [chemical binding]; other site
709986005995	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
709986005996	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
709986005997	Zn2+ binding site [ion binding]; other site
709986005998	Mg2+ binding site [ion binding]; other site
709986005999	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519
709986006000	active site flap/lid [active]
709986006001	nucleophilic elbow; other site
709986006002	catalytic triad [active]
709986006003	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
709986006004	dinuclear metal binding motif [ion binding]; other site
709986006005	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859
709986006006	Transcriptional regulator; Region: Rrf2; cl17282
709986006007	Rrf2 family protein; Region: rrf2_super; TIGR00738
709986006008	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
709986006009	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
709986006010	quinone interaction residues [chemical binding]; other site
709986006011	active site
709986006012	catalytic residues [active]
709986006013	FMN binding site [chemical binding]; other site
709986006014	substrate binding site [chemical binding]; other site
709986006015	dihydroorotase; Validated; Region: pyrC; PRK09357
709986006016	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
709986006017	active site
709986006018	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
709986006019	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
709986006020	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
709986006021	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
709986006022	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
709986006023	active site
709986006024	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
709986006025	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
709986006026	putative dimer interface [polypeptide binding]; other site
709986006027	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
709986006028	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
709986006029	P-loop; other site
709986006030	Magnesium ion binding site [ion binding]; other site
709986006031	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
709986006032	Protein of unknown function (DUF968); Region: DUF968; pfam06147
709986006033	bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379
709986006034	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
709986006035	active site
709986006036	nucleotide binding site [chemical binding]; other site
709986006037	HIGH motif; other site
709986006038	KMSKS motif; other site
709986006039	Ion channel; Region: Ion_trans_2; pfam07885
709986006040	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
709986006041	Double zinc ribbon; Region: DZR; pfam12773
709986006042	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
709986006043	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
709986006044	homodimer interface [polypeptide binding]; other site
709986006045	NAD binding pocket [chemical binding]; other site
709986006046	ATP binding pocket [chemical binding]; other site
709986006047	Mg binding site [ion binding]; other site
709986006048	active-site loop [active]
709986006049	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
709986006050	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
709986006051	active site
709986006052	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
709986006053	nucleotide binding site/active site [active]
709986006054	HIT family signature motif; other site
709986006055	catalytic residue [active]
709986006056	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
709986006057	dinuclear metal binding motif [ion binding]; other site
709986006058	membrane ATPase/protein kinase; Provisional; Region: PRK09435
709986006059	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
709986006060	Walker A; other site
709986006061	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
709986006062	G4 box; other site
709986006063	G5 box; other site
709986006064	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
709986006065	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
709986006066	active site
709986006067	substrate binding site [chemical binding]; other site
709986006068	coenzyme B12 binding site [chemical binding]; other site
709986006069	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
709986006070	B12 binding site [chemical binding]; other site
709986006071	cobalt ligand [ion binding]; other site
709986006072	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
709986006073	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
709986006074	acyl-activating enzyme (AAE) consensus motif; other site
709986006075	AMP binding site [chemical binding]; other site
709986006076	active site
709986006077	CoA binding site [chemical binding]; other site
709986006078	Uncharacterized conserved protein [Function unknown]; Region: COG5316
709986006079	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
709986006080	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
709986006081	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
709986006082	Walker A/P-loop; other site
709986006083	ATP binding site [chemical binding]; other site
709986006084	Q-loop/lid; other site
709986006085	ABC transporter signature motif; other site
709986006086	Walker B; other site
709986006087	D-loop; other site
709986006088	H-loop/switch region; other site
709986006089	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
709986006090	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
709986006091	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
709986006092	Walker A/P-loop; other site
709986006093	ATP binding site [chemical binding]; other site
709986006094	Q-loop/lid; other site
709986006095	ABC transporter signature motif; other site
709986006096	Walker B; other site
709986006097	D-loop; other site
709986006098	H-loop/switch region; other site
709986006099	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
709986006100	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
709986006101	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986006102	dimer interface [polypeptide binding]; other site
709986006103	conserved gate region; other site
709986006104	putative PBP binding loops; other site
709986006105	ABC-ATPase subunit interface; other site
709986006106	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
709986006107	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986006108	dimer interface [polypeptide binding]; other site
709986006109	conserved gate region; other site
709986006110	putative PBP binding loops; other site
709986006111	ABC-ATPase subunit interface; other site
709986006112	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
709986006113	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
709986006114	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
709986006115	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
709986006116	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
709986006117	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
709986006118	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
709986006119	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
709986006120	active site
709986006121	substrate binding site [chemical binding]; other site
709986006122	cosubstrate binding site; other site
709986006123	catalytic site [active]
709986006124	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
709986006125	RNHCP domain; Region: RNHCP; pfam12647
709986006126	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
709986006127	Sm and related proteins; Region: Sm_like; cl00259
709986006128	Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576
709986006129	Sm1 motif; other site
709986006130	RNA binding site [nucleotide binding]; other site
709986006131	transcription termination factor NusA; Region: NusA; TIGR01953
709986006132	NusA N-terminal domain; Region: NusA_N; pfam08529
709986006133	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
709986006134	RNA binding site [nucleotide binding]; other site
709986006135	homodimer interface [polypeptide binding]; other site
709986006136	NusA-like KH domain; Region: KH_5; pfam13184
709986006137	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
709986006138	G-X-X-G motif; other site
709986006139	Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740
709986006140	putative RNA binding cleft [nucleotide binding]; other site
709986006141	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
709986006142	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
709986006143	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
709986006144	G1 box; other site
709986006145	putative GEF interaction site [polypeptide binding]; other site
709986006146	GTP/Mg2+ binding site [chemical binding]; other site
709986006147	Switch I region; other site
709986006148	G2 box; other site
709986006149	G3 box; other site
709986006150	Switch II region; other site
709986006151	G4 box; other site
709986006152	G5 box; other site
709986006153	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
709986006154	Translation-initiation factor 2; Region: IF-2; pfam11987
709986006155	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
709986006156	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
709986006157	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
709986006158	Protein export membrane protein; Region: SecD_SecF; pfam02355
709986006159	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
709986006160	DHH family; Region: DHH; pfam01368
709986006161	DHHA1 domain; Region: DHHA1; pfam02272
709986006162	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
709986006163	Cytochrome P450; Region: p450; cl12078
709986006164	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
709986006165	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
709986006166	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
709986006167	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
709986006168	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
709986006169	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
709986006170	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
709986006171	ABC transporter; Region: ABC_tran_2; pfam12848
709986006172	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
709986006173	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986006174	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986006175	metal binding site [ion binding]; metal-binding site
709986006176	active site
709986006177	I-site; other site
709986006178	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
709986006179	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
709986006180	dimer interface [polypeptide binding]; other site
709986006181	phosphorylation site [posttranslational modification]
709986006182	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986006183	ATP binding site [chemical binding]; other site
709986006184	Mg2+ binding site [ion binding]; other site
709986006185	G-X-G motif; other site
709986006186	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
709986006187	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
709986006188	active site
709986006189	Zn binding site [ion binding]; other site
709986006190	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
709986006191	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
709986006192	Uncharacterized conserved protein [Function unknown]; Region: COG1432
709986006193	LabA_like proteins; Region: LabA; cd10911
709986006194	putative metal binding site [ion binding]; other site
709986006195	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
709986006196	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
709986006197	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
709986006198	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
709986006199	putative active site [active]
709986006200	metal binding site [ion binding]; metal-binding site
709986006201	homodimer binding site [polypeptide binding]; other site
709986006202	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
709986006203	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
709986006204	3D domain; Region: 3D; cl01439
709986006205	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
709986006206	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
709986006207	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
709986006208	Cell division protein FtsL; Region: FtsL; cl11433
709986006209	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
709986006210	MraW methylase family; Region: Methyltransf_5; cl17771
709986006211	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
709986006212	MraZ protein; Region: MraZ; pfam02381
709986006213	MraZ protein; Region: MraZ; pfam02381
709986006214	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
709986006215	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
709986006216	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
709986006217	RNA binding surface [nucleotide binding]; other site
709986006218	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
709986006219	active site
709986006220	tRNA pseudouridine synthase B; Provisional; Region: PRK14122
709986006221	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
709986006222	RNA binding site [nucleotide binding]; other site
709986006223	active site
709986006224	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
709986006225	dimerization interface [polypeptide binding]; other site
709986006226	putative DNA binding site [nucleotide binding]; other site
709986006227	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
709986006228	putative Zn2+ binding site [ion binding]; other site
709986006229	AsnC family; Region: AsnC_trans_reg; pfam01037
709986006230	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
709986006231	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
709986006232	hexamer interface [polypeptide binding]; other site
709986006233	ligand binding site [chemical binding]; other site
709986006234	putative active site [active]
709986006235	NAD(P) binding site [chemical binding]; other site
709986006236	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
709986006237	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
709986006238	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
709986006239	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
709986006240	putative dimer interface [polypeptide binding]; other site
709986006241	active site pocket [active]
709986006242	putative cataytic base [active]
709986006243	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
709986006244	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
709986006245	homotrimer interface [polypeptide binding]; other site
709986006246	Walker A motif; other site
709986006247	GTP binding site [chemical binding]; other site
709986006248	Walker B motif; other site
709986006249	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
709986006250	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
709986006251	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
709986006252	catalytic triad [active]
709986006253	cobyric acid synthase; Provisional; Region: PRK00784
709986006254	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
709986006255	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
709986006256	catalytic triad [active]
709986006257	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
709986006258	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
709986006259	pyridoxal 5'-phosphate binding site [chemical binding]; other site
709986006260	homodimer interface [polypeptide binding]; other site
709986006261	catalytic residue [active]
709986006262	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
709986006263	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
709986006264	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
709986006265	homodimer interface [polypeptide binding]; other site
709986006266	Walker A motif; other site
709986006267	ATP binding site [chemical binding]; other site
709986006268	hydroxycobalamin binding site [chemical binding]; other site
709986006269	Walker B motif; other site
709986006270	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
709986006271	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
709986006272	putative binding site residues; other site
709986006273	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
709986006274	catalytic core [active]
709986006275	Cobalamin-5-phosphate synthase [Coenzyme metabolism]; Region: CobS; COG0368
709986006276	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
709986006277	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
709986006278	active site
709986006279	HIGH motif; other site
709986006280	KMSKS motif; other site
709986006281	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
709986006282	tRNA binding surface [nucleotide binding]; other site
709986006283	anticodon binding site; other site
709986006284	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
709986006285	dimer interface [polypeptide binding]; other site
709986006286	putative tRNA-binding site [nucleotide binding]; other site
709986006287	trehalose synthase; Region: treS_nterm; TIGR02456
709986006288	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
709986006289	active site
709986006290	homodimer interface [polypeptide binding]; other site
709986006291	catalytic site [active]
709986006292	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706
709986006293	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
709986006294	metal binding triad [ion binding]; metal-binding site
709986006295	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
709986006296	Zn2+ binding site [ion binding]; other site
709986006297	Mg2+ binding site [ion binding]; other site
709986006298	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
709986006299	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
709986006300	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
709986006301	nudix motif; other site
709986006302	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
709986006303	active site
709986006304	catalytic residues [active]
709986006305	Uncharacterized conserved protein [Function unknown]; Region: COG4850
709986006306	Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949
709986006307	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
709986006308	putative catalytic site [active]
709986006309	putative metal binding site [ion binding]; other site
709986006310	putative phosphate binding site [ion binding]; other site
709986006311	ribonuclease R; Region: RNase_R; TIGR02063
709986006312	RNB domain; Region: RNB; pfam00773
709986006313	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
709986006314	RNA binding site [nucleotide binding]; other site
709986006315	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
709986006316	S-adenosylmethionine binding site [chemical binding]; other site
709986006317	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
709986006318	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
709986006319	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
709986006320	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
709986006321	elongation factor P; Validated; Region: PRK00529
709986006322	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
709986006323	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
709986006324	RNA binding site [nucleotide binding]; other site
709986006325	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
709986006326	RNA binding site [nucleotide binding]; other site
709986006327	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
709986006328	phosphate acetyltransferase; Reviewed; Region: PRK05632
709986006329	DRTGG domain; Region: DRTGG; pfam07085
709986006330	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
709986006331	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
709986006332	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
709986006333	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
709986006334	NAD(P) binding site [chemical binding]; other site
709986006335	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
709986006336	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
709986006337	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
709986006338	NAD(P) binding site [chemical binding]; other site
709986006339	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986006340	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986006341	metal binding site [ion binding]; metal-binding site
709986006342	active site
709986006343	I-site; other site
709986006344	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
709986006345	glycyl-tRNA synthetase; Provisional; Region: PRK04173
709986006346	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
709986006347	motif 1; other site
709986006348	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
709986006349	active site
709986006350	motif 2; other site
709986006351	motif 3; other site
709986006352	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
709986006353	anticodon binding site; other site
709986006354	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
709986006355	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
709986006356	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
709986006357	dimerization interface [polypeptide binding]; other site
709986006358	ligand binding site [chemical binding]; other site
709986006359	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
709986006360	active site 2 [active]
709986006361	active site 1 [active]
709986006362	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
709986006363	hypothetical protein; Provisional; Region: PRK08201
709986006364	metal binding site [ion binding]; metal-binding site
709986006365	putative dimer interface [polypeptide binding]; other site
709986006366	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
709986006367	active site
709986006368	metal binding site [ion binding]; metal-binding site
709986006369	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
709986006370	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
709986006371	DNA binding residues [nucleotide binding]
709986006372	putative dimer interface [polypeptide binding]; other site
709986006373	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
709986006374	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
709986006375	DNA binding residues [nucleotide binding]
709986006376	putative dimer interface [polypeptide binding]; other site
709986006377	Inward rectifier potassium channel; Region: IRK; pfam01007
709986006378	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
709986006379	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
709986006380	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
709986006381	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
709986006382	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
709986006383	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
709986006384	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
709986006385	homodimer interface [polypeptide binding]; other site
709986006386	substrate-cofactor binding pocket; other site
709986006387	pyridoxal 5'-phosphate binding site [chemical binding]; other site
709986006388	catalytic residue [active]
709986006389	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
709986006390	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
709986006391	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
709986006392	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
709986006393	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
709986006394	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
709986006395	motif II; other site
709986006396	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
709986006397	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
709986006398	minor groove reading motif; other site
709986006399	helix-hairpin-helix signature motif; other site
709986006400	substrate binding pocket [chemical binding]; other site
709986006401	active site
709986006402	ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443
709986006403	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
709986006404	dimer interface [polypeptide binding]; other site
709986006405	motif 1; other site
709986006406	active site
709986006407	motif 2; other site
709986006408	motif 3; other site
709986006409	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
709986006410	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
709986006411	Phosphotransferase enzyme family; Region: APH; pfam01636
709986006412	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
709986006413	active site
709986006414	ATP binding site [chemical binding]; other site
709986006415	PAS fold; Region: PAS_4; pfam08448
709986006416	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
709986006417	putative active site [active]
709986006418	heme pocket [chemical binding]; other site
709986006419	PAS domain; Region: PAS_9; pfam13426
709986006420	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986006421	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986006422	metal binding site [ion binding]; metal-binding site
709986006423	active site
709986006424	I-site; other site
709986006425	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
709986006426	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
709986006427	Transcriptional regulators [Transcription]; Region: PurR; COG1609
709986006428	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
709986006429	DNA binding site [nucleotide binding]
709986006430	domain linker motif; other site
709986006431	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
709986006432	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
709986006433	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
709986006434	ATP binding site [chemical binding]; other site
709986006435	putative Mg++ binding site [ion binding]; other site
709986006436	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
709986006437	nucleotide binding region [chemical binding]; other site
709986006438	ATP-binding site [chemical binding]; other site
709986006439	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
709986006440	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
709986006441	Cu(I) binding site [ion binding]; other site
709986006442	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173
709986006443	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
709986006444	hypothetical protein; Provisional; Region: PRK14013
709986006445	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
709986006446	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
709986006447	putative metal binding site [ion binding]; other site
709986006448	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
709986006449	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
709986006450	putative metal binding site [ion binding]; other site
709986006451	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
709986006452	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
709986006453	putative metal binding site [ion binding]; other site
709986006454	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
709986006455	metal ion-dependent adhesion site (MIDAS); other site
709986006456	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
709986006457	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
709986006458	putative metal binding site [ion binding]; other site
709986006459	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
709986006460	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
709986006461	recombination protein F; Provisional; Region: recF; PRK14079
709986006462	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
709986006463	Walker A/P-loop; other site
709986006464	ATP binding site [chemical binding]; other site
709986006465	Q-loop/lid; other site
709986006466	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
709986006467	ABC transporter signature motif; other site
709986006468	Walker B; other site
709986006469	D-loop; other site
709986006470	H-loop/switch region; other site
709986006471	Protein of unknown function (DUF721); Region: DUF721; pfam05258
709986006472	Protein of unknown function (DUF721); Region: DUF721; cl02324
709986006473	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
709986006474	MPT binding site; other site
709986006475	trimer interface [polypeptide binding]; other site
709986006476	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
709986006477	dinuclear metal binding motif [ion binding]; other site
709986006478	Ferritin-like domain; Region: Ferritin_2; pfam13668
709986006479	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
709986006480	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
709986006481	HIGH motif; other site
709986006482	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
709986006483	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
709986006484	active site
709986006485	KMSKS motif; other site
709986006486	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
709986006487	tRNA binding surface [nucleotide binding]; other site
709986006488	anticodon binding site; other site
709986006489	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
709986006490	CARDB; Region: CARDB; pfam07705
709986006491	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
709986006492	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
709986006493	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
709986006494	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
709986006495	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
709986006496	phosphate binding site [ion binding]; other site
709986006497	putative substrate binding pocket [chemical binding]; other site
709986006498	dimer interface [polypeptide binding]; other site
709986006499	Domon-like ligand-binding domains; Region: DOMON_like; cl14783
709986006500	putative ligand binding site [chemical binding]; other site
709986006501	Predicted transcriptional regulators [Transcription]; Region: COG1733
709986006502	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
709986006503	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
709986006504	classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370
709986006505	putative NAD(P) binding site [chemical binding]; other site
709986006506	active site
709986006507	EamA-like transporter family; Region: EamA; pfam00892
709986006508	Protein of unknown function (DUF4127); Region: DUF4127; pfam13552
709986006509	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
709986006510	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
709986006511	FtsX-like permease family; Region: FtsX; pfam02687
709986006512	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
709986006513	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
709986006514	Walker A/P-loop; other site
709986006515	ATP binding site [chemical binding]; other site
709986006516	Q-loop/lid; other site
709986006517	ABC transporter signature motif; other site
709986006518	Walker B; other site
709986006519	D-loop; other site
709986006520	H-loop/switch region; other site
709986006521	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
709986006522	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
709986006523	active site
709986006524	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
709986006525	dimer interface [polypeptide binding]; other site
709986006526	substrate binding site [chemical binding]; other site
709986006527	catalytic residues [active]
709986006528	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
709986006529	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
709986006530	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
709986006531	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
709986006532	DNA binding residues [nucleotide binding]
709986006533	drug binding residues [chemical binding]; other site
709986006534	dimer interface [polypeptide binding]; other site
709986006535	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
709986006536	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
709986006537	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
709986006538	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986006539	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986006540	metal binding site [ion binding]; metal-binding site
709986006541	active site
709986006542	I-site; other site
709986006543	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
709986006544	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
709986006545	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
709986006546	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
709986006547	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
709986006548	Coenzyme A binding pocket [chemical binding]; other site
709986006549	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
709986006550	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
709986006551	glutamine binding [chemical binding]; other site
709986006552	catalytic triad [active]
709986006553	anthranilate synthase component I; Provisional; Region: PRK13565
709986006554	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
709986006555	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
709986006556	Domain of unknown function (DUF1795); Region: DUF1795; cl02256
709986006557	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
709986006558	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
709986006559	active site
709986006560	FMN binding site [chemical binding]; other site
709986006561	substrate binding site [chemical binding]; other site
709986006562	homotetramer interface [polypeptide binding]; other site
709986006563	catalytic residue [active]
709986006564	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
709986006565	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
709986006566	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
709986006567	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
709986006568	TPP-binding site; other site
709986006569	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
709986006570	PYR/PP interface [polypeptide binding]; other site
709986006571	dimer interface [polypeptide binding]; other site
709986006572	TPP binding site [chemical binding]; other site
709986006573	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
709986006574	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
709986006575	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
709986006576	active site
709986006577	metal binding site [ion binding]; metal-binding site
709986006578	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
709986006579	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
709986006580	FAD dependent oxidoreductase; Region: DAO; pfam01266
709986006581	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
709986006582	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
709986006583	ThiS interaction site; other site
709986006584	putative active site [active]
709986006585	tetramer interface [polypeptide binding]; other site
709986006586	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
709986006587	thiS-thiF/thiG interaction site; other site
709986006588	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
709986006589	thiamine phosphate binding site [chemical binding]; other site
709986006590	active site
709986006591	pyrophosphate binding site [ion binding]; other site
709986006592	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
709986006593	ThiC-associated domain; Region: ThiC-associated; pfam13667
709986006594	ThiC family; Region: ThiC; pfam01964
709986006595	short chain dehydrogenase; Provisional; Region: PRK08303
709986006596	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
709986006597	NAD(P) binding site [chemical binding]; other site
709986006598	active site
709986006599	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
709986006600	dimer interface [polypeptide binding]; other site
709986006601	substrate binding site [chemical binding]; other site
709986006602	ATP binding site [chemical binding]; other site
709986006603	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
709986006604	putative homodimer interface [polypeptide binding]; other site
709986006605	putative active site pocket [active]
709986006606	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
709986006607	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
709986006608	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
709986006609	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
709986006610	ATP binding site [chemical binding]; other site
709986006611	putative Mg++ binding site [ion binding]; other site
709986006612	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
709986006613	nucleotide binding region [chemical binding]; other site
709986006614	ATP-binding site [chemical binding]; other site
709986006615	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
709986006616	HRDC domain; Region: HRDC; pfam00570
709986006617	Cytochrome c; Region: Cytochrom_C; pfam00034
709986006618	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
709986006619	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
709986006620	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
709986006621	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
709986006622	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
709986006623	dimerization interface [polypeptide binding]; other site
709986006624	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
709986006625	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
709986006626	dimerization interface [polypeptide binding]; other site
709986006627	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
709986006628	dimerization interface [polypeptide binding]; other site
709986006629	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
709986006630	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
709986006631	dimerization interface [polypeptide binding]; other site
709986006632	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
709986006633	dimerization interface [polypeptide binding]; other site
709986006634	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
709986006635	dimerization interface [polypeptide binding]; other site
709986006636	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
709986006637	dimerization interface [polypeptide binding]; other site
709986006638	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
709986006639	dimerization interface [polypeptide binding]; other site
709986006640	GAF domain; Region: GAF_2; pfam13185
709986006641	GAF domain; Region: GAF; pfam01590
709986006642	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986006643	ATP binding site [chemical binding]; other site
709986006644	Mg2+ binding site [ion binding]; other site
709986006645	G-X-G motif; other site
709986006646	Response regulator receiver domain; Region: Response_reg; pfam00072
709986006647	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986006648	active site
709986006649	phosphorylation site [posttranslational modification]
709986006650	intermolecular recognition site; other site
709986006651	dimerization interface [polypeptide binding]; other site
709986006652	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
709986006653	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986006654	active site
709986006655	phosphorylation site [posttranslational modification]
709986006656	intermolecular recognition site; other site
709986006657	dimerization interface [polypeptide binding]; other site
709986006658	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
709986006659	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986006660	active site
709986006661	phosphorylation site [posttranslational modification]
709986006662	intermolecular recognition site; other site
709986006663	dimerization interface [polypeptide binding]; other site
709986006664	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
709986006665	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
709986006666	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
709986006667	Response regulator receiver domain; Region: Response_reg; pfam00072
709986006668	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986006669	active site
709986006670	phosphorylation site [posttranslational modification]
709986006671	intermolecular recognition site; other site
709986006672	dimerization interface [polypeptide binding]; other site
709986006673	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986006674	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
709986006675	putative active site [active]
709986006676	heme pocket [chemical binding]; other site
709986006677	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
709986006678	dimer interface [polypeptide binding]; other site
709986006679	phosphorylation site [posttranslational modification]
709986006680	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986006681	ATP binding site [chemical binding]; other site
709986006682	Mg2+ binding site [ion binding]; other site
709986006683	G-X-G motif; other site
709986006684	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
709986006685	homodimer interface [polypeptide binding]; other site
709986006686	pyridoxal 5'-phosphate binding site [chemical binding]; other site
709986006687	catalytic residue [active]
709986006688	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
709986006689	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
709986006690	ligand binding site [chemical binding]; other site
709986006691	NAD binding site [chemical binding]; other site
709986006692	dimerization interface [polypeptide binding]; other site
709986006693	catalytic site [active]
709986006694	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
709986006695	putative L-serine binding site [chemical binding]; other site
709986006696	GAF domain; Region: GAF_2; pfam13185
709986006697	GAF domain; Region: GAF_3; pfam13492
709986006698	PAS domain S-box; Region: sensory_box; TIGR00229
709986006699	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986006700	putative active site [active]
709986006701	heme pocket [chemical binding]; other site
709986006702	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
709986006703	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986006704	putative active site [active]
709986006705	PAS fold; Region: PAS_3; pfam08447
709986006706	heme pocket [chemical binding]; other site
709986006707	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
709986006708	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986006709	putative active site [active]
709986006710	heme pocket [chemical binding]; other site
709986006711	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
709986006712	dimer interface [polypeptide binding]; other site
709986006713	phosphorylation site [posttranslational modification]
709986006714	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986006715	ATP binding site [chemical binding]; other site
709986006716	Mg2+ binding site [ion binding]; other site
709986006717	G-X-G motif; other site
709986006718	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
709986006719	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
709986006720	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
709986006721	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
709986006722	Peptidase family M23; Region: Peptidase_M23; pfam01551
709986006723	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
709986006724	putative active site [active]
709986006725	dimerization interface [polypeptide binding]; other site
709986006726	putative tRNAtyr binding site [nucleotide binding]; other site
709986006727	Domain of unknown function (DUF1844); Region: DUF1844; pfam08899
709986006728	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
709986006729	Fe-S cluster binding site [ion binding]; other site
709986006730	active site
709986006731	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
709986006732	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
709986006733	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
709986006734	NlpC/P60 family; Region: NLPC_P60; pfam00877
709986006735	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
709986006736	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
709986006737	Amidase; Region: Amidase; cl11426
709986006738	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
709986006739	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
709986006740	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
709986006741	active site
709986006742	metal binding site [ion binding]; metal-binding site
709986006743	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14334
709986006744	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
709986006745	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
709986006746	FeS/SAM binding site; other site
709986006747	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
709986006748	Glucose inhibited division protein A; Region: GIDA; pfam01134
709986006749	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
709986006750	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
709986006751	putative NAD(P) binding site [chemical binding]; other site
709986006752	dimer interface [polypeptide binding]; other site
709986006753	Predicted transcriptional regulators [Transcription]; Region: COG1733
709986006754	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
709986006755	dimerization interface [polypeptide binding]; other site
709986006756	putative DNA binding site [nucleotide binding]; other site
709986006757	putative Zn2+ binding site [ion binding]; other site
709986006758	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
709986006759	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
709986006760	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
709986006761	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
709986006762	[2Fe-2S] cluster binding site [ion binding]; other site
709986006763	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
709986006764	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
709986006765	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
709986006766	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190
709986006767	cleavage site
709986006768	active site
709986006769	substrate binding sites [chemical binding]; other site
709986006770	Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297
709986006771	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
709986006772	FeS assembly protein SufD; Region: sufD; TIGR01981
709986006773	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
709986006774	FeS assembly protein SufB; Region: sufB; TIGR01980
709986006775	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
709986006776	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
709986006777	Walker A/P-loop; other site
709986006778	ATP binding site [chemical binding]; other site
709986006779	Q-loop/lid; other site
709986006780	ABC transporter signature motif; other site
709986006781	Walker B; other site
709986006782	D-loop; other site
709986006783	H-loop/switch region; other site
709986006784	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
709986006785	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
709986006786	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
709986006787	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
709986006788	nucleotide binding site [chemical binding]; other site
709986006789	Type III pantothenate kinase; Region: Pan_kinase; cl17198
709986006790	chaperone protein DnaJ; Provisional; Region: PRK14292
709986006791	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
709986006792	HSP70 interaction site [polypeptide binding]; other site
709986006793	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
709986006794	Zn binding sites [ion binding]; other site
709986006795	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
709986006796	dimer interface [polypeptide binding]; other site
709986006797	Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462
709986006798	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
709986006799	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
709986006800	active site
709986006801	Domain of unknown function (DUF427); Region: DUF427; pfam04248
709986006802	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
709986006803	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
709986006804	active site
709986006805	catalytic site [active]
709986006806	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
709986006807	Interdomain contacts; other site
709986006808	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
709986006809	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
709986006810	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
709986006811	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
709986006812	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
709986006813	cobalamin binding residues [chemical binding]; other site
709986006814	putative BtuC binding residues; other site
709986006815	dimer interface [polypeptide binding]; other site
709986006816	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
709986006817	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
709986006818	NAD(P) binding site [chemical binding]; other site
709986006819	Iron permease FTR1 family; Region: FTR1; cl00475
709986006820	Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056
709986006821	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
709986006822	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
709986006823	active site
709986006824	metal binding site [ion binding]; metal-binding site
709986006825	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
709986006826	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
709986006827	active site
709986006828	DNA polymerase IV; Validated; Region: PRK02406
709986006829	DNA binding site [nucleotide binding]
709986006830	Predicted transcriptional regulator [Transcription]; Region: COG2378
709986006831	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
709986006832	dimerization interface [polypeptide binding]; other site
709986006833	putative Zn2+ binding site [ion binding]; other site
709986006834	putative DNA binding site [nucleotide binding]; other site
709986006835	WYL domain; Region: WYL; pfam13280
709986006836	DinB family; Region: DinB; cl17821
709986006837	DinB superfamily; Region: DinB_2; pfam12867
709986006838	Erythromycin esterase; Region: Erythro_esteras; pfam05139
709986006839	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
709986006840	active site
709986006841	PAS fold; Region: PAS_4; pfam08448
709986006842	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986006843	putative active site [active]
709986006844	heme pocket [chemical binding]; other site
709986006845	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986006846	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986006847	metal binding site [ion binding]; metal-binding site
709986006848	active site
709986006849	I-site; other site
709986006850	acetyl-CoA acetyltransferase; Provisional; Region: PRK07661
709986006851	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
709986006852	dimer interface [polypeptide binding]; other site
709986006853	active site
709986006854	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
709986006855	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
709986006856	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
709986006857	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
709986006858	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
709986006859	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
709986006860	substrate binding site [chemical binding]; other site
709986006861	oxyanion hole (OAH) forming residues; other site
709986006862	trimer interface [polypeptide binding]; other site
709986006863	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
709986006864	C-terminal peptidase (prc); Region: prc; TIGR00225
709986006865	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
709986006866	protein binding site [polypeptide binding]; other site
709986006867	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
709986006868	Active site serine [active]
709986006869	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
709986006870	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
709986006871	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
709986006872	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
709986006873	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
709986006874	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
709986006875	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
709986006876	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
709986006877	active site
709986006878	PHP-associated; Region: PHP_C; pfam13263
709986006879	Protein of unknown function (DUF2716); Region: DUF2716; pfam10898
709986006880	transaminase, acetylornithine/succinylornithine family; Region: argD; TIGR00707
709986006881	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
709986006882	inhibitor-cofactor binding pocket; inhibition site
709986006883	pyridoxal 5'-phosphate binding site [chemical binding]; other site
709986006884	catalytic residue [active]
709986006885	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118
709986006886	dimer interface [polypeptide binding]; other site
709986006887	Citrate synthase; Region: Citrate_synt; pfam00285
709986006888	active site
709986006889	coenzyme A binding site [chemical binding]; other site
709986006890	citrylCoA binding site [chemical binding]; other site
709986006891	oxalacetate/citrate binding site [chemical binding]; other site
709986006892	catalytic triad [active]
709986006893	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
709986006894	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
709986006895	phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975
709986006896	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
709986006897	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986006898	dimer interface [polypeptide binding]; other site
709986006899	conserved gate region; other site
709986006900	putative PBP binding loops; other site
709986006901	ABC-ATPase subunit interface; other site
709986006902	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
709986006903	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986006904	dimer interface [polypeptide binding]; other site
709986006905	conserved gate region; other site
709986006906	putative PBP binding loops; other site
709986006907	ABC-ATPase subunit interface; other site
709986006908	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
709986006909	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
709986006910	Walker A/P-loop; other site
709986006911	ATP binding site [chemical binding]; other site
709986006912	Q-loop/lid; other site
709986006913	ABC transporter signature motif; other site
709986006914	Walker B; other site
709986006915	D-loop; other site
709986006916	H-loop/switch region; other site
709986006917	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
709986006918	PhoU domain; Region: PhoU; pfam01895
709986006919	PhoU domain; Region: PhoU; pfam01895
709986006920	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
709986006921	Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077
709986006922	calcium binding site 2 [ion binding]; other site
709986006923	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
709986006924	active site
709986006925	catalytic triad [active]
709986006926	calcium binding site 1 [ion binding]; other site
709986006927	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
709986006928	Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077
709986006929	calcium binding site 2 [ion binding]; other site
709986006930	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
709986006931	active site
709986006932	catalytic triad [active]
709986006933	calcium binding site 1 [ion binding]; other site
709986006934	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
709986006935	putative active site pocket [active]
709986006936	4-fold oligomerization interface [polypeptide binding]; other site
709986006937	metal binding residues [ion binding]; metal-binding site
709986006938	3-fold/trimer interface [polypeptide binding]; other site
709986006939	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181
709986006940	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
709986006941	putative active site [active]
709986006942	oxyanion strand; other site
709986006943	catalytic triad [active]
709986006944	glycogen branching enzyme; Provisional; Region: PRK14706
709986006945	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
709986006946	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
709986006947	active site
709986006948	catalytic site [active]
709986006949	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
709986006950	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
709986006951	TAP-like protein; Region: Abhydrolase_4; pfam08386
709986006952	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
709986006953	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
709986006954	S-adenosylmethionine binding site [chemical binding]; other site
709986006955	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
709986006956	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
709986006957	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
709986006958	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
709986006959	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
709986006960	DNA binding residues [nucleotide binding]
709986006961	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
709986006962	MoxR-like ATPases [General function prediction only]; Region: COG0714
709986006963	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
709986006964	ATP binding site [chemical binding]; other site
709986006965	Walker A motif; other site
709986006966	Walker B motif; other site
709986006967	arginine finger; other site
709986006968	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
709986006969	Protein of unknown function DUF58; Region: DUF58; pfam01882
709986006970	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
709986006971	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
709986006972	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
709986006973	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
709986006974	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
709986006975	formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK14811
709986006976	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
709986006977	DNA binding site [nucleotide binding]
709986006978	catalytic residue [active]
709986006979	H2TH interface [polypeptide binding]; other site
709986006980	putative catalytic residues [active]
709986006981	turnover-facilitating residue; other site
709986006982	intercalation triad [nucleotide binding]; other site
709986006983	8OG recognition residue [nucleotide binding]; other site
709986006984	putative reading head residues; other site
709986006985	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
709986006986	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
709986006987	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
709986006988	putative substrate binding pocket [chemical binding]; other site
709986006989	AC domain interface; other site
709986006990	catalytic triad [active]
709986006991	AB domain interface; other site
709986006992	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
709986006993	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
709986006994	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
709986006995	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
709986006996	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
709986006997	NAD(P) binding site [chemical binding]; other site
709986006998	active site
709986006999	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
709986007000	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
709986007001	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
709986007002	Coenzyme A binding pocket [chemical binding]; other site
709986007003	CHASE domain; Region: CHASE; pfam03924
709986007004	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986007005	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
709986007006	putative active site [active]
709986007007	heme pocket [chemical binding]; other site
709986007008	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986007009	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
709986007010	putative active site [active]
709986007011	heme pocket [chemical binding]; other site
709986007012	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986007013	putative active site [active]
709986007014	heme pocket [chemical binding]; other site
709986007015	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
709986007016	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
709986007017	dimer interface [polypeptide binding]; other site
709986007018	phosphorylation site [posttranslational modification]
709986007019	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986007020	ATP binding site [chemical binding]; other site
709986007021	Mg2+ binding site [ion binding]; other site
709986007022	G-X-G motif; other site
709986007023	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
709986007024	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986007025	active site
709986007026	phosphorylation site [posttranslational modification]
709986007027	intermolecular recognition site; other site
709986007028	dimerization interface [polypeptide binding]; other site
709986007029	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
709986007030	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
709986007031	dimer interface [polypeptide binding]; other site
709986007032	phosphorylation site [posttranslational modification]
709986007033	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986007034	ATP binding site [chemical binding]; other site
709986007035	Mg2+ binding site [ion binding]; other site
709986007036	G-X-G motif; other site
709986007037	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
709986007038	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
709986007039	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
709986007040	NAD(P) binding site [chemical binding]; other site
709986007041	shikimate binding site; other site
709986007042	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
709986007043	PhoH-like protein; Region: PhoH; pfam02562
709986007044	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986007045	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986007046	metal binding site [ion binding]; metal-binding site
709986007047	active site
709986007048	I-site; other site
709986007049	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319
709986007050	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
709986007051	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
709986007052	Domain of unknown function DUF21; Region: DUF21; pfam01595
709986007053	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
709986007054	Transporter associated domain; Region: CorC_HlyC; smart01091
709986007055	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
709986007056	active site
709986007057	catalytic motif [active]
709986007058	Zn binding site [ion binding]; other site
709986007059	Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998
709986007060	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
709986007061	Major Facilitator Superfamily; Region: MFS_1; pfam07690
709986007062	putative substrate translocation pore; other site
709986007063	GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451
709986007064	GIY-YIG motif/motif A; other site
709986007065	Protein of unknown function (DUF1517); Region: DUF1517; cl01807
709986007066	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354
709986007067	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
709986007068	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
709986007069	generic binding surface II; other site
709986007070	ssDNA binding site; other site
709986007071	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
709986007072	ATP binding site [chemical binding]; other site
709986007073	putative Mg++ binding site [ion binding]; other site
709986007074	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
709986007075	nucleotide binding region [chemical binding]; other site
709986007076	ATP-binding site [chemical binding]; other site
709986007077	Protein of unknown function (DUF2572); Region: DUF2572; pfam10833
709986007078	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
709986007079	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
709986007080	putative NAD(P) binding site [chemical binding]; other site
709986007081	active site
709986007082	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
709986007083	DEAD-like helicases superfamily; Region: DEXDc; smart00487
709986007084	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
709986007085	ATP binding site [chemical binding]; other site
709986007086	putative Mg++ binding site [ion binding]; other site
709986007087	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
709986007088	nucleotide binding region [chemical binding]; other site
709986007089	ATP-binding site [chemical binding]; other site
709986007090	TRCF domain; Region: TRCF; pfam03461
709986007091	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
709986007092	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
709986007093	substrate binding site [chemical binding]; other site
709986007094	hexamer interface [polypeptide binding]; other site
709986007095	metal binding site [ion binding]; metal-binding site
709986007096	2-phosphosulfolactate phosphatase; Provisional; Region: PRK14100
709986007097	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029
709986007098	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
709986007099	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
709986007100	putative catalytic cysteine [active]
709986007101	gamma-glutamyl kinase; Provisional; Region: PRK05429
709986007102	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
709986007103	nucleotide binding site [chemical binding]; other site
709986007104	homotetrameric interface [polypeptide binding]; other site
709986007105	putative phosphate binding site [ion binding]; other site
709986007106	putative allosteric binding site; other site
709986007107	PUA domain; Region: PUA; pfam01472
709986007108	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
709986007109	tetramer (dimer of dimers) interface [polypeptide binding]; other site
709986007110	active site
709986007111	dimer interface [polypeptide binding]; other site
709986007112	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
709986007113	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
709986007114	catalytic triad [active]
709986007115	Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144
709986007116	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
709986007117	intersubunit interface [polypeptide binding]; other site
709986007118	active site
709986007119	catalytic residue [active]
709986007120	Maf-like protein; Provisional; Region: PRK14361
709986007121	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
709986007122	active site
709986007123	dimer interface [polypeptide binding]; other site
709986007124	basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576
709986007125	rod shape-determining protein MreC; Provisional; Region: PRK13922
709986007126	rod shape-determining protein MreC; Region: MreC; pfam04085
709986007127	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
709986007128	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
709986007129	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
709986007130	H+ Antiporter protein; Region: 2A0121; TIGR00900
709986007131	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
709986007132	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
709986007133	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
709986007134	RNA/DNA hybrid binding site [nucleotide binding]; other site
709986007135	active site
709986007136	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
709986007137	hydrophobic ligand binding site; other site
709986007138	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
709986007139	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
709986007140	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
709986007141	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
709986007142	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
709986007143	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359
709986007144	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
709986007145	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
709986007146	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
709986007147	putative active site [active]
709986007148	epoxyqueuosine reductase; Region: TIGR00276
709986007149	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
709986007150	4Fe-4S binding domain; Region: Fer4_6; pfam12837
709986007151	SnoaL-like domain; Region: SnoaL_2; pfam12680
709986007152	PQQ-like domain; Region: PQQ_2; pfam13360
709986007153	thymidylate kinase; Validated; Region: tmk; PRK00698
709986007154	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
709986007155	TMP-binding site; other site
709986007156	ATP-binding site [chemical binding]; other site
709986007157	Uncharacterized conserved protein [Function unknown]; Region: COG0327
709986007158	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
709986007159	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
709986007160	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
709986007161	dimer interface [polypeptide binding]; other site
709986007162	putative metal binding site [ion binding]; other site
709986007163	Predicted transcriptional regulators [Transcription]; Region: COG1378
709986007164	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
709986007165	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
709986007166	C-terminal domain interface [polypeptide binding]; other site
709986007167	sugar binding site [chemical binding]; other site
709986007168	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
709986007169	C-terminal peptidase (prc); Region: prc; TIGR00225
709986007170	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
709986007171	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
709986007172	Catalytic dyad [active]
709986007173	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
709986007174	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
709986007175	Walker A/P-loop; other site
709986007176	ATP binding site [chemical binding]; other site
709986007177	Q-loop/lid; other site
709986007178	ABC transporter signature motif; other site
709986007179	Walker B; other site
709986007180	D-loop; other site
709986007181	H-loop/switch region; other site
709986007182	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
709986007183	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
709986007184	Peptidase family M23; Region: Peptidase_M23; pfam01551
709986007185	Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228
709986007186	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
709986007187	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
709986007188	G-X-X-G motif; other site
709986007189	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13829
709986007190	RimM N-terminal domain; Region: RimM; pfam01782
709986007191	PRC-barrel domain; Region: PRC; pfam05239
709986007192	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
709986007193	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
709986007194	DNA gyrase subunit A; Validated; Region: PRK05560
709986007195	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
709986007196	CAP-like domain; other site
709986007197	active site
709986007198	primary dimer interface [polypeptide binding]; other site
709986007199	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
709986007200	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
709986007201	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
709986007202	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
709986007203	CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918
709986007204	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
709986007205	ligand binding site [chemical binding]; other site
709986007206	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
709986007207	putative switch regulator; other site
709986007208	non-specific DNA interactions [nucleotide binding]; other site
709986007209	DNA binding site [nucleotide binding]
709986007210	sequence specific DNA binding site [nucleotide binding]; other site
709986007211	putative cAMP binding site [chemical binding]; other site
709986007212	ferredoxin-NADP+ reductase; Region: PLN02852
709986007213	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
709986007214	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986007215	putative active site [active]
709986007216	heme pocket [chemical binding]; other site
709986007217	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986007218	metal binding site [ion binding]; metal-binding site
709986007219	active site
709986007220	I-site; other site
709986007221	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
709986007222	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
709986007223	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
709986007224	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051
709986007225	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
709986007226	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
709986007227	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
709986007228	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
709986007229	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
709986007230	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
709986007231	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
709986007232	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
709986007233	dimerization interface [polypeptide binding]; other site
709986007234	ligand binding site [chemical binding]; other site
709986007235	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
709986007236	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
709986007237	TM-ABC transporter signature motif; other site
709986007238	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
709986007239	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
709986007240	TM-ABC transporter signature motif; other site
709986007241	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
709986007242	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
709986007243	Walker A/P-loop; other site
709986007244	ATP binding site [chemical binding]; other site
709986007245	Q-loop/lid; other site
709986007246	ABC transporter signature motif; other site
709986007247	Walker B; other site
709986007248	D-loop; other site
709986007249	H-loop/switch region; other site
709986007250	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
709986007251	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
709986007252	Walker A/P-loop; other site
709986007253	ATP binding site [chemical binding]; other site
709986007254	Q-loop/lid; other site
709986007255	ABC transporter signature motif; other site
709986007256	Walker B; other site
709986007257	D-loop; other site
709986007258	H-loop/switch region; other site
709986007259	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
709986007260	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
709986007261	peptide binding site [polypeptide binding]; other site
709986007262	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
709986007263	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986007264	dimer interface [polypeptide binding]; other site
709986007265	conserved gate region; other site
709986007266	putative PBP binding loops; other site
709986007267	ABC-ATPase subunit interface; other site
709986007268	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
709986007269	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986007270	dimer interface [polypeptide binding]; other site
709986007271	conserved gate region; other site
709986007272	putative PBP binding loops; other site
709986007273	ABC-ATPase subunit interface; other site
709986007274	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
709986007275	active site
709986007276	dimerization interface [polypeptide binding]; other site
709986007277	ribonuclease PH; Reviewed; Region: rph; PRK00173
709986007278	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
709986007279	oligomer interface [polypeptide binding]; other site
709986007280	RNA binding site [nucleotide binding]; other site
709986007281	glutamate racemase; Provisional; Region: PRK00865
709986007282	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
709986007283	4Fe-4S binding domain; Region: Fer4; pfam00037
709986007284	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
709986007285	FOG: WD40 repeat [General function prediction only]; Region: COG2319
709986007286	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
709986007287	Transcriptional regulator [Transcription]; Region: LysR; COG0583
709986007288	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
709986007289	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
709986007290	dimerization interface [polypeptide binding]; other site
709986007291	Flagellin N-methylase; Region: FliB; cl00497
709986007292	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
709986007293	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
709986007294	Coenzyme A binding pocket [chemical binding]; other site
709986007295	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
709986007296	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
709986007297	NADP binding site [chemical binding]; other site
709986007298	dimer interface [polypeptide binding]; other site
709986007299	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
709986007300	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
709986007301	dimer interface [polypeptide binding]; other site
709986007302	active site
709986007303	glycine-pyridoxal phosphate binding site [chemical binding]; other site
709986007304	folate binding site [chemical binding]; other site
709986007305	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986007306	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986007307	metal binding site [ion binding]; metal-binding site
709986007308	active site
709986007309	I-site; other site
709986007310	PAS domain S-box; Region: sensory_box; TIGR00229
709986007311	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
709986007312	putative active site [active]
709986007313	heme pocket [chemical binding]; other site
709986007314	GAF domain; Region: GAF; pfam01590
709986007315	GAF domain; Region: GAF_2; pfam13185
709986007316	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986007317	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
709986007318	putative active site [active]
709986007319	heme pocket [chemical binding]; other site
709986007320	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986007321	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
709986007322	putative active site [active]
709986007323	heme pocket [chemical binding]; other site
709986007324	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986007325	putative active site [active]
709986007326	heme pocket [chemical binding]; other site
709986007327	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
709986007328	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
709986007329	Zn2+ binding site [ion binding]; other site
709986007330	Mg2+ binding site [ion binding]; other site
709986007331	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986007332	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986007333	metal binding site [ion binding]; metal-binding site
709986007334	active site
709986007335	I-site; other site
709986007336	peptide chain release factor 2; Validated; Region: prfB; PRK00578
709986007337	PCRF domain; Region: PCRF; pfam03462
709986007338	RF-1 domain; Region: RF-1; pfam00472
709986007339	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
709986007340	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
709986007341	Resolvase, N terminal domain; Region: Resolvase; smart00857
709986007342	catalytic residues [active]
709986007343	Recombinase; Region: Recombinase; pfam07508
709986007344	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
709986007345	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
709986007346	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
709986007347	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
709986007348	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
709986007349	minor groove reading motif; other site
709986007350	helix-hairpin-helix signature motif; other site
709986007351	substrate binding pocket [chemical binding]; other site
709986007352	active site
709986007353	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
709986007354	Major Facilitator Superfamily; Region: MFS_1; pfam07690
709986007355	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
709986007356	Putative zinc ribbon domain; Region: DUF164; pfam02591
709986007357	magnesium protoporphyrin O-methyltransferase; Region: BchM-ChlM; TIGR02021
709986007358	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
709986007359	S-adenosylmethionine binding site [chemical binding]; other site
709986007360	glucose-6-phosphate isomerase; Provisional; Region: PRK00973
709986007361	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
709986007362	dimer interface [polypeptide binding]; other site
709986007363	active site
709986007364	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
709986007365	dimer interface [polypeptide binding]; other site
709986007366	active site
709986007367	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
709986007368	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
709986007369	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
709986007370	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
709986007371	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
709986007372	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
709986007373	DNA-binding site [nucleotide binding]; DNA binding site
709986007374	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
709986007375	pyridoxal 5'-phosphate binding site [chemical binding]; other site
709986007376	homodimer interface [polypeptide binding]; other site
709986007377	catalytic residue [active]
709986007378	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
709986007379	acetylornithine aminotransferase; Provisional; Region: PRK02627
709986007380	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
709986007381	inhibitor-cofactor binding pocket; inhibition site
709986007382	pyridoxal 5'-phosphate binding site [chemical binding]; other site
709986007383	catalytic residue [active]
709986007384	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
709986007385	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
709986007386	Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977
709986007387	ArsC family; Region: ArsC; pfam03960
709986007388	catalytic residue [active]
709986007389	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
709986007390	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
709986007391	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986007392	dimer interface [polypeptide binding]; other site
709986007393	conserved gate region; other site
709986007394	putative PBP binding loops; other site
709986007395	ABC-ATPase subunit interface; other site
709986007396	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
709986007397	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986007398	putative PBP binding loops; other site
709986007399	ABC-ATPase subunit interface; other site
709986007400	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
709986007401	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
709986007402	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
709986007403	dimerization interface [polypeptide binding]; other site
709986007404	putative DNA binding site [nucleotide binding]; other site
709986007405	putative Zn2+ binding site [ion binding]; other site
709986007406	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
709986007407	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
709986007408	nucleotide binding site [chemical binding]; other site
709986007409	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
709986007410	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
709986007411	Uncharacterized conserved protein [Function unknown]; Region: COG5316
709986007412	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
709986007413	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
709986007414	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
709986007415	dimer interface [polypeptide binding]; other site
709986007416	putative anticodon binding site; other site
709986007417	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
709986007418	motif 1; other site
709986007419	active site
709986007420	motif 2; other site
709986007421	motif 3; other site
709986007422	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
709986007423	Uncharacterized conserved protein, YhbC family [Function unknown]; Region: COG0782
709986007424	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
709986007425	Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381
709986007426	Recombination protein O N terminal; Region: RecO_N; pfam11967
709986007427	Recombination protein O C terminal; Region: RecO_C; pfam02565
709986007428	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
709986007429	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
709986007430	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
709986007431	E-class dimer interface [polypeptide binding]; other site
709986007432	P-class dimer interface [polypeptide binding]; other site
709986007433	active site
709986007434	Cu2+ binding site [ion binding]; other site
709986007435	Zn2+ binding site [ion binding]; other site
709986007436	Cellulose binding domain; Region: CBM_2; cl17741
709986007437	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
709986007438	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
709986007439	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
709986007440	active site
709986007441	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
709986007442	sequence-specific DNA binding site [nucleotide binding]; other site
709986007443	salt bridge; other site
709986007444	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
709986007445	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
709986007446	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
709986007447	active site
709986007448	catalytic residues [active]
709986007449	metal binding site [ion binding]; metal-binding site
709986007450	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
709986007451	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
709986007452	DNA binding residues [nucleotide binding]
709986007453	B12 binding domain; Region: B12-binding_2; pfam02607
709986007454	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
709986007455	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
709986007456	ligand binding site [chemical binding]; other site
709986007457	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
709986007458	putative switch regulator; other site
709986007459	non-specific DNA interactions [nucleotide binding]; other site
709986007460	DNA binding site [nucleotide binding]
709986007461	sequence specific DNA binding site [nucleotide binding]; other site
709986007462	putative cAMP binding site [chemical binding]; other site
709986007463	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
709986007464	putative NAD(P) binding site [chemical binding]; other site
709986007465	active site
709986007466	phytoene desaturase; Region: crtI_fam; TIGR02734
709986007467	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
709986007468	active site lid residues [active]
709986007469	substrate binding pocket [chemical binding]; other site
709986007470	catalytic residues [active]
709986007471	substrate-Mg2+ binding site; other site
709986007472	aspartate-rich region 1; other site
709986007473	aspartate-rich region 2; other site
709986007474	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
709986007475	S-adenosylmethionine binding site [chemical binding]; other site
709986007476	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
709986007477	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
709986007478	metal binding site 2 [ion binding]; metal-binding site
709986007479	putative DNA binding helix; other site
709986007480	metal binding site 1 [ion binding]; metal-binding site
709986007481	dimer interface [polypeptide binding]; other site
709986007482	structural Zn2+ binding site [ion binding]; other site
709986007483	Astacin (Peptidase family M12A); Region: Astacin; pfam01400
709986007484	Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to...; Region: ZnMc_astacin_like; cd04280
709986007485	active site
709986007486	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
709986007487	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
709986007488	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
709986007489	intersubunit interface [polypeptide binding]; other site
709986007490	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
709986007491	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
709986007492	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
709986007493	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
709986007494	dimer interface [polypeptide binding]; other site
709986007495	NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370
709986007496	dimer interface [polypeptide binding]; other site
709986007497	FMN binding site [chemical binding]; other site
709986007498	Predicted transcriptional regulators [Transcription]; Region: COG1733
709986007499	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
709986007500	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
709986007501	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
709986007502	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
709986007503	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
709986007504	DEAD-like helicases superfamily; Region: DEXDc; smart00487
709986007505	ATP binding site [chemical binding]; other site
709986007506	Mg++ binding site [ion binding]; other site
709986007507	motif III; other site
709986007508	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
709986007509	nucleotide binding region [chemical binding]; other site
709986007510	ATP-binding site [chemical binding]; other site
709986007511	RNA-binding GUCT-like domain found in Thermus thermophilus heat resistant RNA-dependent ATPase (Hera) and similar proteins; Region: GUCT_Hera; cd12938
709986007512	Protein of unknown function (DUF3995); Region: DUF3995; pfam13160
709986007513	Thymidine kinase [Nucleotide transport and metabolism]; Region: Tdk; COG1435
709986007514	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
709986007515	MarR family; Region: MarR_2; cl17246
709986007516	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
709986007517	Protein of unknown function, DUF606; Region: DUF606; pfam04657
709986007518	Protein of unknown function, DUF606; Region: DUF606; pfam04657
709986007519	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
709986007520	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986007521	active site
709986007522	phosphorylation site [posttranslational modification]
709986007523	intermolecular recognition site; other site
709986007524	dimerization interface [polypeptide binding]; other site
709986007525	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
709986007526	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
709986007527	dimer interface [polypeptide binding]; other site
709986007528	phosphorylation site [posttranslational modification]
709986007529	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986007530	ATP binding site [chemical binding]; other site
709986007531	Mg2+ binding site [ion binding]; other site
709986007532	G-X-G motif; other site
709986007533	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
709986007534	Major Facilitator Superfamily; Region: MFS_1; pfam07690
709986007535	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
709986007536	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986007537	ATP binding site [chemical binding]; other site
709986007538	Mg2+ binding site [ion binding]; other site
709986007539	G-X-G motif; other site
709986007540	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
709986007541	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
709986007542	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
709986007543	MutS domain I; Region: MutS_I; pfam01624
709986007544	MutS domain II; Region: MutS_II; pfam05188
709986007545	MutS domain III; Region: MutS_III; pfam05192
709986007546	MutS domain V; Region: MutS_V; pfam00488
709986007547	Walker A/P-loop; other site
709986007548	ATP binding site [chemical binding]; other site
709986007549	Q-loop/lid; other site
709986007550	ABC transporter signature motif; other site
709986007551	Walker B; other site
709986007552	D-loop; other site
709986007553	H-loop/switch region; other site
709986007554	Protein of unknown function (DUF1453); Region: DUF1453; cl02009
709986007555	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
709986007556	Cytochrome P450; Region: p450; cl12078
709986007557	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
709986007558	Major Facilitator Superfamily; Region: MFS_1; pfam07690
709986007559	Helix-turn-helix domain; Region: HTH_17; pfam12728
709986007560	Protein of unknown function (DUF402); Region: DUF402; cl00979
709986007561	Protein of unknown function (DUF554); Region: DUF554; cl00784
709986007562	potassium/proton antiporter; Reviewed; Region: PRK05326
709986007563	TrkA-C domain; Region: TrkA_C; pfam02080
709986007564	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
709986007565	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
709986007566	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
709986007567	catalytic residue [active]
709986007568	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
709986007569	seryl-tRNA synthetase; Provisional; Region: PRK05431
709986007570	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
709986007571	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
709986007572	dimer interface [polypeptide binding]; other site
709986007573	active site
709986007574	motif 1; other site
709986007575	motif 2; other site
709986007576	motif 3; other site
709986007577	EamA-like transporter family; Region: EamA; pfam00892
709986007578	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
709986007579	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
709986007580	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
709986007581	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
709986007582	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
709986007583	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
709986007584	Walker A/P-loop; other site
709986007585	ATP binding site [chemical binding]; other site
709986007586	Q-loop/lid; other site
709986007587	ABC transporter signature motif; other site
709986007588	Walker B; other site
709986007589	D-loop; other site
709986007590	H-loop/switch region; other site
709986007591	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
709986007592	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
709986007593	Walker A/P-loop; other site
709986007594	ATP binding site [chemical binding]; other site
709986007595	Q-loop/lid; other site
709986007596	ABC transporter signature motif; other site
709986007597	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
709986007598	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
709986007599	catalytic triad [active]
709986007600	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
709986007601	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
709986007602	substrate binding site [chemical binding]; other site
709986007603	oxyanion hole (OAH) forming residues; other site
709986007604	trimer interface [polypeptide binding]; other site
709986007605	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
709986007606	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
709986007607	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
709986007608	Walker A motif; other site
709986007609	ATP binding site [chemical binding]; other site
709986007610	Walker B motif; other site
709986007611	arginine finger; other site
709986007612	Peptidase family M41; Region: Peptidase_M41; pfam01434
709986007613	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
709986007614	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
709986007615	nucleotide binding site [chemical binding]; other site
709986007616	NEF interaction site [polypeptide binding]; other site
709986007617	SBD interface [polypeptide binding]; other site
709986007618	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
709986007619	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
709986007620	dimer interface [polypeptide binding]; other site
709986007621	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
709986007622	chaperone protein DnaJ; Provisional; Region: PRK14299
709986007623	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
709986007624	HSP70 interaction site [polypeptide binding]; other site
709986007625	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
709986007626	substrate binding site [polypeptide binding]; other site
709986007627	dimer interface [polypeptide binding]; other site
709986007628	Tetratricopeptide repeat; Region: TPR_12; pfam13424
709986007629	Tetratricopeptide repeat; Region: TPR_12; pfam13424
709986007630	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
709986007631	binding surface
709986007632	TPR motif; other site
709986007633	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
709986007634	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
709986007635	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
709986007636	Walker A/P-loop; other site
709986007637	ATP binding site [chemical binding]; other site
709986007638	Q-loop/lid; other site
709986007639	ABC transporter signature motif; other site
709986007640	Walker B; other site
709986007641	D-loop; other site
709986007642	H-loop/switch region; other site
709986007643	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
709986007644	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
709986007645	Walker A/P-loop; other site
709986007646	ATP binding site [chemical binding]; other site
709986007647	Q-loop/lid; other site
709986007648	ABC transporter signature motif; other site
709986007649	Walker B; other site
709986007650	D-loop; other site
709986007651	H-loop/switch region; other site
709986007652	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
709986007653	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
709986007654	TM-ABC transporter signature motif; other site
709986007655	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
709986007656	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
709986007657	TM-ABC transporter signature motif; other site
709986007658	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
709986007659	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
709986007660	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
709986007661	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
709986007662	ligand binding site [chemical binding]; other site
709986007663	homoserine O-acetyltransferase; Provisional; Region: PRK06765
709986007664	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
709986007665	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
709986007666	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
709986007667	Bacterial transcriptional activator domain; Region: BTAD; smart01043
709986007668	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
709986007669	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
709986007670	NAD(P) binding site [chemical binding]; other site
709986007671	active site
709986007672	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
709986007673	active site
709986007674	catalytic residues [active]
709986007675	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
709986007676	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
709986007677	active site
709986007678	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
709986007679	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
709986007680	putative active site [active]
709986007681	putative metal binding site [ion binding]; other site
709986007682	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
709986007683	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
709986007684	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
709986007685	active site
709986007686	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
709986007687	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
709986007688	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
709986007689	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
709986007690	trimer interface [polypeptide binding]; other site
709986007691	putative metal binding site [ion binding]; other site
709986007692	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
709986007693	active site
709986007694	Ap6A binding site [chemical binding]; other site
709986007695	nudix motif; other site
709986007696	metal binding site [ion binding]; metal-binding site
709986007697	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
709986007698	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
709986007699	homodimer interface [polypeptide binding]; other site
709986007700	substrate-cofactor binding pocket; other site
709986007701	pyridoxal 5'-phosphate binding site [chemical binding]; other site
709986007702	catalytic residue [active]
709986007703	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
709986007704	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
709986007705	NAD(P) binding site [chemical binding]; other site
709986007706	active site
709986007707	Nitronate monooxygenase; Region: NMO; pfam03060
709986007708	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
709986007709	FMN binding site [chemical binding]; other site
709986007710	substrate binding site [chemical binding]; other site
709986007711	putative catalytic residue [active]
709986007712	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
709986007713	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
709986007714	active site
709986007715	catalytic tetrad [active]
709986007716	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
709986007717	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
709986007718	DNA binding residues [nucleotide binding]
709986007719	putative dimer interface [polypeptide binding]; other site
709986007720	manganese transport protein MntH; Reviewed; Region: PRK00701
709986007721	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
709986007722	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
709986007723	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
709986007724	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
709986007725	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
709986007726	Walker A motif; other site
709986007727	ATP binding site [chemical binding]; other site
709986007728	Walker B motif; other site
709986007729	arginine finger; other site
709986007730	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
709986007731	Walker A motif; other site
709986007732	ATP binding site [chemical binding]; other site
709986007733	Walker B motif; other site
709986007734	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
709986007735	Uncharacterized conserved protein [Function unknown]; Region: COG2127
709986007736	Uncharacterized conserved protein [Function unknown]; Region: COG2013
709986007737	glycogen synthase; Provisional; Region: glgA; PRK00654
709986007738	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
709986007739	ADP-binding pocket [chemical binding]; other site
709986007740	homodimer interface [polypeptide binding]; other site
709986007741	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
709986007742	TAP-like protein; Region: Abhydrolase_4; pfam08386
709986007743	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
709986007744	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
709986007745	GAF domain; Region: GAF_3; pfam13492
709986007746	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
709986007747	Histidine kinase; Region: HisKA_3; pfam07730
709986007748	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986007749	ATP binding site [chemical binding]; other site
709986007750	Mg2+ binding site [ion binding]; other site
709986007751	G-X-G motif; other site
709986007752	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986007753	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986007754	metal binding site [ion binding]; metal-binding site
709986007755	active site
709986007756	I-site; other site
709986007757	GAF domain; Region: GAF; cl17456
709986007758	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
709986007759	Zn2+ binding site [ion binding]; other site
709986007760	Mg2+ binding site [ion binding]; other site
709986007761	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
709986007762	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
709986007763	FMN binding site [chemical binding]; other site
709986007764	active site
709986007765	catalytic residues [active]
709986007766	substrate binding site [chemical binding]; other site
709986007767	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
709986007768	Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077
709986007769	calcium binding site 2 [ion binding]; other site
709986007770	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
709986007771	active site
709986007772	catalytic triad [active]
709986007773	calcium binding site 1 [ion binding]; other site
709986007774	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
709986007775	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
709986007776	oligomer interface [polypeptide binding]; other site
709986007777	active site
709986007778	metal binding site [ion binding]; metal-binding site
709986007779	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
709986007780	Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427
709986007781	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
709986007782	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
709986007783	FeS/SAM binding site; other site
709986007784	GAF domain; Region: GAF_3; pfam13492
709986007785	GAF domain; Region: GAF_2; pfam13185
709986007786	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986007787	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986007788	metal binding site [ion binding]; metal-binding site
709986007789	active site
709986007790	I-site; other site
709986007791	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
709986007792	hydrophobic ligand binding site; other site
709986007793	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
709986007794	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
709986007795	HflX GTPase family; Region: HflX; cd01878
709986007796	G1 box; other site
709986007797	GTP/Mg2+ binding site [chemical binding]; other site
709986007798	Switch I region; other site
709986007799	G2 box; other site
709986007800	G3 box; other site
709986007801	Switch II region; other site
709986007802	G4 box; other site
709986007803	G5 box; other site
709986007804	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
709986007805	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
709986007806	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
709986007807	Walker A/P-loop; other site
709986007808	ATP binding site [chemical binding]; other site
709986007809	Q-loop/lid; other site
709986007810	ABC transporter signature motif; other site
709986007811	Walker B; other site
709986007812	D-loop; other site
709986007813	H-loop/switch region; other site
709986007814	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
709986007815	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
709986007816	active site
709986007817	catalytic tetrad [active]
709986007818	H+ Antiporter protein; Region: 2A0121; TIGR00900
709986007819	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
709986007820	putative substrate translocation pore; other site
709986007821	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
709986007822	transmembrane helices; other site
709986007823	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
709986007824	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
709986007825	TrkA-C domain; Region: TrkA_C; pfam02080
709986007826	TrkA-C domain; Region: TrkA_C; pfam02080
709986007827	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
709986007828	M20 Peptidase acetylornithine deacetylase/acetyl-lysine deacetylase; Region: M20_ArgE_LysK; cd05653
709986007829	acetyl-lysine deacetylase; Provisional; Region: PRK04443
709986007830	metal binding site [ion binding]; metal-binding site
709986007831	putative dimer interface [polypeptide binding]; other site
709986007832	GAF domain; Region: GAF_2; pfam13185
709986007833	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
709986007834	GAF domain; Region: GAF_3; pfam13492
709986007835	GAF domain; Region: GAF_2; pfam13185
709986007836	PAS domain S-box; Region: sensory_box; TIGR00229
709986007837	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
709986007838	putative active site [active]
709986007839	heme pocket [chemical binding]; other site
709986007840	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
709986007841	Histidine kinase; Region: HisKA_3; pfam07730
709986007842	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
709986007843	ATP binding site [chemical binding]; other site
709986007844	G-X-G motif; other site
709986007845	Domain of unkown function (DUF1775); Region: DUF1775; pfam07987
709986007846	Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043
709986007847	DHH family; Region: DHH; pfam01368
709986007848	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
709986007849	CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918
709986007850	ligand binding site [chemical binding]; other site
709986007851	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
709986007852	putative switch regulator; other site
709986007853	non-specific DNA interactions [nucleotide binding]; other site
709986007854	DNA binding site [nucleotide binding]
709986007855	sequence specific DNA binding site [nucleotide binding]; other site
709986007856	putative cAMP binding site [chemical binding]; other site
709986007857	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
709986007858	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
709986007859	putative active site [active]
709986007860	Zn binding site [ion binding]; other site
709986007861	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
709986007862	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
709986007863	active site
709986007864	dimerization interface [polypeptide binding]; other site
709986007865	adenylosuccinate lyase; Provisional; Region: PRK07492
709986007866	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
709986007867	tetramer interface [polypeptide binding]; other site
709986007868	active site
709986007869	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
709986007870	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
709986007871	S-adenosylmethionine binding site [chemical binding]; other site
709986007872	Membrane protein of unknown function; Region: DUF360; pfam04020
709986007873	Pantoate-beta-alanine ligase; Region: PanC; cd00560
709986007874	active site
709986007875	ATP-binding site [chemical binding]; other site
709986007876	pantoate-binding site; other site
709986007877	HXXH motif; other site
709986007878	pilus retraction protein PilT; Region: pilT_fam; TIGR01420
709986007879	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
709986007880	Walker A motif; other site
709986007881	ATP binding site [chemical binding]; other site
709986007882	Walker B motif; other site
709986007883	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
709986007884	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
709986007885	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
709986007886	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
709986007887	Glycoprotease family; Region: Peptidase_M22; pfam00814
709986007888	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
709986007889	putative active site [active]
709986007890	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
709986007891	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
709986007892	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
709986007893	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
709986007894	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
709986007895	Walker A/P-loop; other site
709986007896	ATP binding site [chemical binding]; other site
709986007897	Q-loop/lid; other site
709986007898	ABC transporter signature motif; other site
709986007899	Walker B; other site
709986007900	D-loop; other site
709986007901	H-loop/switch region; other site
709986007902	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
709986007903	FAD binding domain; Region: FAD_binding_4; pfam01565
709986007904	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
709986007905	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
709986007906	Catalytic site [active]
709986007907	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
709986007908	Predicted transcriptional regulators [Transcription]; Region: COG1695
709986007909	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
709986007910	BON domain; Region: BON; cl02771
709986007911	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
709986007912	enoyl-CoA hydratase; Provisional; Region: PRK05862
709986007913	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
709986007914	substrate binding site [chemical binding]; other site
709986007915	oxyanion hole (OAH) forming residues; other site
709986007916	trimer interface [polypeptide binding]; other site
709986007917	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
709986007918	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
709986007919	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cl00653
709986007920	Active_site [active]
709986007921	Response regulator receiver domain; Region: Response_reg; pfam00072
709986007922	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986007923	active site
709986007924	phosphorylation site [posttranslational modification]
709986007925	intermolecular recognition site; other site
709986007926	dimerization interface [polypeptide binding]; other site
709986007927	GAF domain; Region: GAF_2; pfam13185
709986007928	GAF domain; Region: GAF_3; pfam13492
709986007929	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
709986007930	dimer interface [polypeptide binding]; other site
709986007931	phosphorylation site [posttranslational modification]
709986007932	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986007933	ATP binding site [chemical binding]; other site
709986007934	Mg2+ binding site [ion binding]; other site
709986007935	G-X-G motif; other site
709986007936	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
709986007937	Predicted dehydrogenase [General function prediction only]; Region: COG5322
709986007938	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
709986007939	NAD(P) binding pocket [chemical binding]; other site
709986007940	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
709986007941	active site
709986007942	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
709986007943	active site
709986007944	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217
709986007945	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
709986007946	RNA methyltransferase, RsmE family; Region: TIGR00046
709986007947	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
709986007948	Methyltransferase domain; Region: Methyltransf_18; pfam12847
709986007949	GAF domain; Region: GAF_2; pfam13185
709986007950	GAF domain; Region: GAF_3; pfam13492
709986007951	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
709986007952	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
709986007953	Zn2+ binding site [ion binding]; other site
709986007954	Mg2+ binding site [ion binding]; other site
709986007955	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
709986007956	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
709986007957	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
709986007958	Ligand binding site; other site
709986007959	Putative Catalytic site; other site
709986007960	DXD motif; other site
709986007961	Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056
709986007962	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
709986007963	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
709986007964	active site
709986007965	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
709986007966	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
709986007967	putative substrate binding region [chemical binding]; other site
709986007968	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
709986007969	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
709986007970	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
709986007971	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
709986007972	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
709986007973	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
709986007974	ribosome recycling factor; Reviewed; Region: frr; PRK00083
709986007975	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
709986007976	hinge region; other site
709986007977	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
709986007978	putative nucleotide binding site [chemical binding]; other site
709986007979	uridine monophosphate binding site [chemical binding]; other site
709986007980	homohexameric interface [polypeptide binding]; other site
709986007981	elongation factor Ts; Provisional; Region: tsf; PRK09377
709986007982	UBA/TS-N domain; Region: UBA; pfam00627
709986007983	Elongation factor TS; Region: EF_TS; pfam00889
709986007984	Elongation factor TS; Region: EF_TS; pfam00889
709986007985	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
709986007986	rRNA interaction site [nucleotide binding]; other site
709986007987	S8 interaction site; other site
709986007988	putative laminin-1 binding site; other site
709986007989	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
709986007990	TPR repeat; Region: TPR_11; pfam13414
709986007991	binding surface
709986007992	TPR motif; other site
709986007993	TPR repeat; Region: TPR_11; pfam13414
709986007994	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
709986007995	binding surface
709986007996	TPR motif; other site
709986007997	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
709986007998	TPR motif; other site
709986007999	TPR repeat; Region: TPR_11; pfam13414
709986008000	binding surface
709986008001	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
709986008002	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
709986008003	CoA-binding site [chemical binding]; other site
709986008004	ATP-binding [chemical binding]; other site
709986008005	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
709986008006	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
709986008007	active site
709986008008	HIGH motif; other site
709986008009	dimer interface [polypeptide binding]; other site
709986008010	KMSKS motif; other site
709986008011	CTP synthetase; Validated; Region: pyrG; PRK05380
709986008012	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
709986008013	Catalytic site [active]
709986008014	active site
709986008015	UTP binding site [chemical binding]; other site
709986008016	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
709986008017	active site
709986008018	putative oxyanion hole; other site
709986008019	catalytic triad [active]
709986008020	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
709986008021	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
709986008022	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
709986008023	transcription elongation factor GreA; Region: greA; TIGR01462
709986008024	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
709986008025	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
709986008026	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
709986008027	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
709986008028	Ligand Binding Site [chemical binding]; other site
709986008029	diaminopimelate decarboxylase; Region: lysA; TIGR01048
709986008030	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
709986008031	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
709986008032	catalytic residue [active]
709986008033	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
709986008034	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
709986008035	NAD(P) binding site [chemical binding]; other site
709986008036	active site
709986008037	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
709986008038	nucleoside/Zn binding site; other site
709986008039	dimer interface [polypeptide binding]; other site
709986008040	catalytic motif [active]
709986008041	Protein of unknown function (DUF1572); Region: DUF1572; pfam07609
709986008042	DinB superfamily; Region: DinB_2; pfam12867
709986008043	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
709986008044	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
709986008045	Walker A/P-loop; other site
709986008046	ATP binding site [chemical binding]; other site
709986008047	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
709986008048	ABC transporter signature motif; other site
709986008049	Walker B; other site
709986008050	D-loop; other site
709986008051	H-loop/switch region; other site
709986008052	ABC transporter; Region: ABC_tran_2; pfam12848
709986008053	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
709986008054	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
709986008055	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
709986008056	Helix-turn-helix domain; Region: HTH_18; pfam12833
709986008057	Predicted periplasmic protein [Function unknown]; Region: COG3698
709986008058	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
709986008059	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
709986008060	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
709986008061	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
709986008062	active site
709986008063	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
709986008064	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
709986008065	tetramer interface [polypeptide binding]; other site
709986008066	pyridoxal 5'-phosphate binding site [chemical binding]; other site
709986008067	catalytic residue [active]
709986008068	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
709986008069	active site
709986008070	SUMO-1 interface [polypeptide binding]; other site
709986008071	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
709986008072	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
709986008073	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
709986008074	Prolyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ProS; COG0442
709986008075	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
709986008076	motif 1; other site
709986008077	dimer interface [polypeptide binding]; other site
709986008078	active site
709986008079	motif 2; other site
709986008080	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
709986008081	active site
709986008082	motif 3; other site
709986008083	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
709986008084	anticodon binding site; other site
709986008085	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
709986008086	bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625
709986008087	active site
709986008088	metal binding site [ion binding]; metal-binding site
709986008089	Peptidase M14 Carboxypeptidase T-like subfamily; Region: M14_CPT_like; cd06226
709986008090	putative active site [active]
709986008091	Zn binding site [ion binding]; other site
709986008092	ornithine carbamoyltransferase; Provisional; Region: PRK00779
709986008093	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
709986008094	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
709986008095	PAAR motif; Region: PAAR_motif; pfam05488
709986008096	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
709986008097	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
709986008098	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
709986008099	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
709986008100	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
709986008101	Na binding site [ion binding]; other site
709986008102	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
709986008103	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
709986008104	heterotetramer interface [polypeptide binding]; other site
709986008105	active site pocket [active]
709986008106	cleavage site
709986008107	metal-dependent hydrolase; Provisional; Region: PRK13291
709986008108	DinB superfamily; Region: DinB_2; pfam12867
709986008109	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
709986008110	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
709986008111	ring oligomerisation interface [polypeptide binding]; other site
709986008112	ATP/Mg binding site [chemical binding]; other site
709986008113	stacking interactions; other site
709986008114	hinge regions; other site
709986008115	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
709986008116	oligomerisation interface [polypeptide binding]; other site
709986008117	mobile loop; other site
709986008118	roof hairpin; other site
709986008119	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986008120	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986008121	metal binding site [ion binding]; metal-binding site
709986008122	active site
709986008123	I-site; other site
709986008124	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4295
709986008125	Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021
709986008126	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
709986008127	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
709986008128	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
709986008129	integral membrane protein MviN; Region: mviN; TIGR01695
709986008130	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
709986008131	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
709986008132	putative active site [active]
709986008133	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
709986008134	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
709986008135	active site
709986008136	interdomain interaction site; other site
709986008137	putative metal-binding site [ion binding]; other site
709986008138	nucleotide binding site [chemical binding]; other site
709986008139	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
709986008140	domain I; other site
709986008141	phosphate binding site [ion binding]; other site
709986008142	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
709986008143	domain II; other site
709986008144	domain III; other site
709986008145	nucleotide binding site [chemical binding]; other site
709986008146	DNA binding groove [nucleotide binding]
709986008147	catalytic site [active]
709986008148	domain IV; other site
709986008149	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
709986008150	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
709986008151	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
709986008152	HSP90 family protein; Provisional; Region: PRK14083
709986008153	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986008154	ATP binding site [chemical binding]; other site
709986008155	Mg2+ binding site [ion binding]; other site
709986008156	G-X-G motif; other site
709986008157	Domain of unknown function (DUF4424); Region: DUF4424; pfam14415
709986008158	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
709986008159	Uncharacterized conserved protein [Function unknown]; Region: COG0062
709986008160	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
709986008161	putative substrate binding site [chemical binding]; other site
709986008162	putative ATP binding site [chemical binding]; other site
709986008163	TPR repeat; Region: TPR_11; pfam13414
709986008164	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
709986008165	binding surface
709986008166	TPR motif; other site
709986008167	TPR repeat; Region: TPR_11; pfam13414
709986008168	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
709986008169	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
709986008170	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
709986008171	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
709986008172	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
709986008173	substrate binding site [chemical binding]; other site
709986008174	ATP binding site [chemical binding]; other site
709986008175	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
709986008176	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
709986008177	5S rRNA interface [nucleotide binding]; other site
709986008178	CTC domain interface [polypeptide binding]; other site
709986008179	L16 interface [polypeptide binding]; other site
709986008180	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
709986008181	prolyl-tRNA synthetase; Provisional; Region: PRK08661
709986008182	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
709986008183	dimer interface [polypeptide binding]; other site
709986008184	motif 1; other site
709986008185	active site
709986008186	motif 2; other site
709986008187	motif 3; other site
709986008188	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
709986008189	anticodon binding site; other site
709986008190	zinc-binding site [ion binding]; other site
709986008191	Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; cl01558
709986008192	Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773
709986008193	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
709986008194	AAA ATPase domain; Region: AAA_16; pfam13191
709986008195	Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324
709986008196	trehalose synthase; Region: treS_nterm; TIGR02456
709986008197	active site
709986008198	catalytic site [active]
709986008199	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
709986008200	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
709986008201	active site
709986008202	metal binding site [ion binding]; metal-binding site
709986008203	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
709986008204	DinB superfamily; Region: DinB_2; pfam12867
709986008205	DinB family; Region: DinB; cl17821
709986008206	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
709986008207	DNA binding site [nucleotide binding]
709986008208	active site
709986008209	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
709986008210	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
709986008211	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
709986008212	homopentamer interface [polypeptide binding]; other site
709986008213	active site
709986008214	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
709986008215	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
709986008216	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
709986008217	dimerization interface [polypeptide binding]; other site
709986008218	active site
709986008219	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
709986008220	Lumazine binding domain; Region: Lum_binding; pfam00677
709986008221	Lumazine binding domain; Region: Lum_binding; pfam00677
709986008222	diaminohydroxyphosphoribosylaminopyrimidine deaminase; Region: PLN02807
709986008223	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
709986008224	catalytic motif [active]
709986008225	Zn binding site [ion binding]; other site
709986008226	RibD C-terminal domain; Region: RibD_C; cl17279
709986008227	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
709986008228	carbohydrate binding site [chemical binding]; other site
709986008229	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
709986008230	carbohydrate binding site [chemical binding]; other site
709986008231	alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103
709986008232	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
709986008233	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
709986008234	Ca binding site [ion binding]; other site
709986008235	active site
709986008236	catalytic site [active]
709986008237	Domain of unknown function (DUF3372); Region: DUF3372; pfam11852
709986008238	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
709986008239	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
709986008240	NAD(P) binding site [chemical binding]; other site
709986008241	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
709986008242	Beta-lactamase; Region: Beta-lactamase; pfam00144
709986008243	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
709986008244	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
709986008245	NAD binding site [chemical binding]; other site
709986008246	homodimer interface [polypeptide binding]; other site
709986008247	active site
709986008248	substrate binding site [chemical binding]; other site
709986008249	Transcriptional regulators [Transcription]; Region: PurR; COG1609
709986008250	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
709986008251	DNA binding site [nucleotide binding]
709986008252	domain linker motif; other site
709986008253	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
709986008254	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
709986008255	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
709986008256	Walker A/P-loop; other site
709986008257	ATP binding site [chemical binding]; other site
709986008258	Q-loop/lid; other site
709986008259	ABC transporter signature motif; other site
709986008260	Walker B; other site
709986008261	D-loop; other site
709986008262	H-loop/switch region; other site
709986008263	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
709986008264	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339
709986008265	Archaeal/vacuolar-type H+-ATPase subunit D [Energy production and conversion]; Region: NtpD; COG1394
709986008266	V-type ATP synthase subunit B; Provisional; Region: PRK04196
709986008267	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
709986008268	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
709986008269	Walker A motif homologous position; other site
709986008270	Walker B motif; other site
709986008271	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
709986008272	V-type ATP synthase subunit A; Provisional; Region: PRK04192
709986008273	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
709986008274	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
709986008275	Walker A motif/ATP binding site; other site
709986008276	Walker B motif; other site
709986008277	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
709986008278	Archaeal/vacuolar-type H+-ATPase subunit F [Energy production and conversion]; Region: NtpG; COG1436
709986008279	Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527
709986008280	V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660
709986008281	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
709986008282	Archaeal/vacuolar-type H+-ATPase subunit I [Energy production and conversion]; Region: NtpI; COG1269
709986008283	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
709986008284	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
709986008285	Nitrogen regulatory protein P-II; Region: P-II; smart00938
709986008286	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
709986008287	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
709986008288	putative active site [active]
709986008289	catalytic residue [active]
709986008290	Protein of unknown function (DUF1999); Region: DUF1999; pfam09390
709986008291	metal-binding site [ion binding]
709986008292	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
709986008293	Protein of unknown function (DUF503); Region: DUF503; pfam04456
709986008294	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
709986008295	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
709986008296	Catalytic site [active]
709986008297	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
709986008298	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
709986008299	Catalytic domain of Protein Kinases; Region: PKc; cd00180
709986008300	active site
709986008301	ATP binding site [chemical binding]; other site
709986008302	substrate binding site [chemical binding]; other site
709986008303	activation loop (A-loop); other site
709986008304	DdrB-like protein; Region: DdrB; pfam12747
709986008305	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
709986008306	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
709986008307	ATP binding site [chemical binding]; other site
709986008308	active site
709986008309	substrate binding site [chemical binding]; other site
709986008310	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
709986008311	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
709986008312	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
709986008313	putative active site [active]
709986008314	catalytic triad [active]
709986008315	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
709986008316	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
709986008317	dimerization interface [polypeptide binding]; other site
709986008318	ATP binding site [chemical binding]; other site
709986008319	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
709986008320	dimerization interface [polypeptide binding]; other site
709986008321	ATP binding site [chemical binding]; other site
709986008322	amidophosphoribosyltransferase; Region: purF; TIGR01134
709986008323	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
709986008324	active site
709986008325	tetramer interface [polypeptide binding]; other site
709986008326	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
709986008327	active site
709986008328	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
709986008329	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
709986008330	active site
709986008331	motif I; other site
709986008332	motif II; other site
709986008333	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
709986008334	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
709986008335	active site
709986008336	homotetramer interface [polypeptide binding]; other site
709986008337	conserved hypothetical protein; Region: TIGR03833
709986008338	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
709986008339	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
709986008340	BON domain; Region: BON; pfam04972
709986008341	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
709986008342	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
709986008343	Protein of unknown function DUF99; Region: DUF99; pfam01949
709986008344	hypothetical protein; Provisional; Region: PRK00766
709986008345	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
709986008346	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
709986008347	TPP-binding site [chemical binding]; other site
709986008348	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
709986008349	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
709986008350	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
709986008351	E3 interaction surface; other site
709986008352	lipoyl attachment site [posttranslational modification]; other site
709986008353	e3 binding domain; Region: E3_binding; pfam02817
709986008354	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
709986008355	Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316
709986008356	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
709986008357	active site
709986008358	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
709986008359	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
709986008360	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
709986008361	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
709986008362	G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189
709986008363	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
709986008364	substrate binding site; other site
709986008365	metal-binding site
709986008366	Oligomer interface; other site
709986008367	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
709986008368	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
709986008369	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
709986008370	FeS/SAM binding site; other site
709986008371	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
709986008372	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
709986008373	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
709986008374	DNA-binding site [nucleotide binding]; DNA binding site
709986008375	UTRA domain; Region: UTRA; pfam07702
709986008376	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
709986008377	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
709986008378	2-phosphoglycerate kinase; Provisional; Region: PRK12337
709986008379	AAA domain; Region: AAA_17; pfam13207
709986008380	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
709986008381	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
709986008382	TrkA-N domain; Region: TrkA_N; pfam02254
709986008383	TrkA-C domain; Region: TrkA_C; pfam02080
709986008384	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
709986008385	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
709986008386	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
709986008387	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
709986008388	S-adenosylmethionine binding site [chemical binding]; other site
709986008389	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
709986008390	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
709986008391	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
709986008392	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
709986008393	DNA binding residues [nucleotide binding]
709986008394	putative anti-sigmaE protein; Provisional; Region: PRK13920
709986008395	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
709986008396	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
709986008397	nucleotide binding site [chemical binding]; other site
709986008398	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
709986008399	23S rRNA binding site [nucleotide binding]; other site
709986008400	L21 binding site [polypeptide binding]; other site
709986008401	L13 binding site [polypeptide binding]; other site
709986008402	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
709986008403	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
709986008404	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
709986008405	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
709986008406	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
709986008407	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
709986008408	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
709986008409	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
709986008410	nudix motif; other site
709986008411	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
709986008412	Protein of unknown function DUF72; Region: DUF72; pfam01904
709986008413	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
709986008414	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
709986008415	glutaminase active site [active]
709986008416	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
709986008417	dimer interface [polypeptide binding]; other site
709986008418	active site
709986008419	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
709986008420	dimer interface [polypeptide binding]; other site
709986008421	active site
709986008422	enoyl-CoA hydratase; Provisional; Region: PRK05995
709986008423	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
709986008424	substrate binding site [chemical binding]; other site
709986008425	oxyanion hole (OAH) forming residues; other site
709986008426	trimer interface [polypeptide binding]; other site
709986008427	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
709986008428	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
709986008429	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
709986008430	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
709986008431	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
709986008432	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
709986008433	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
709986008434	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
709986008435	Substrate-binding site [chemical binding]; other site
709986008436	Substrate specificity [chemical binding]; other site
709986008437	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
709986008438	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
709986008439	Substrate-binding site [chemical binding]; other site
709986008440	Substrate specificity [chemical binding]; other site
709986008441	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
709986008442	4Fe-4S binding domain; Region: Fer4; pfam00037
709986008443	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
709986008444	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
709986008445	UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085
709986008446	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
709986008447	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
709986008448	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
709986008449	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
709986008450	Ligand Binding Site [chemical binding]; other site
709986008451	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
709986008452	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331
709986008453	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
709986008454	active site
709986008455	catalytic site [active]
709986008456	Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438
709986008457	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
709986008458	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986008459	active site
709986008460	phosphorylation site [posttranslational modification]
709986008461	intermolecular recognition site; other site
709986008462	dimerization interface [polypeptide binding]; other site
709986008463	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
709986008464	DNA binding residues [nucleotide binding]
709986008465	dimerization interface [polypeptide binding]; other site
709986008466	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
709986008467	Histidine kinase; Region: HisKA_3; pfam07730
709986008468	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986008469	ATP binding site [chemical binding]; other site
709986008470	Mg2+ binding site [ion binding]; other site
709986008471	G-X-G motif; other site
709986008472	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
709986008473	L-aspartate oxidase; Provisional; Region: PRK06175
709986008474	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
709986008475	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
709986008476	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
709986008477	dimerization interface [polypeptide binding]; other site
709986008478	active site
709986008479	Quinolinate synthetase A protein; Region: NadA; pfam02445
709986008480	Helix-turn-helix; Region: HTH_3; pfam01381
709986008481	non-specific DNA binding site [nucleotide binding]; other site
709986008482	salt bridge; other site
709986008483	sequence-specific DNA binding site [nucleotide binding]; other site
709986008484	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
709986008485	Catalytic site [active]
709986008486	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
709986008487	Catalytic site [active]
709986008488	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
709986008489	active site clefts [active]
709986008490	zinc binding site [ion binding]; other site
709986008491	dimer interface [polypeptide binding]; other site
709986008492	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
709986008493	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
709986008494	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
709986008495	competence damage-inducible protein A; Provisional; Region: PRK00549
709986008496	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
709986008497	putative MPT binding site; other site
709986008498	Competence-damaged protein; Region: CinA; pfam02464
709986008499	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
709986008500	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
709986008501	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
709986008502	RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468
709986008503	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
709986008504	hexamer interface [polypeptide binding]; other site
709986008505	Walker A motif; other site
709986008506	ATP binding site [chemical binding]; other site
709986008507	Walker B motif; other site
709986008508	hypothetical protein; Provisional; Region: PRK12705
709986008509	KH domain; Region: KH_1; pfam00013
709986008510	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
709986008511	Zn2+ binding site [ion binding]; other site
709986008512	Mg2+ binding site [ion binding]; other site
709986008513	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
709986008514	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
709986008515	Active site serine [active]
709986008516	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
709986008517	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986008518	dimer interface [polypeptide binding]; other site
709986008519	conserved gate region; other site
709986008520	putative PBP binding loops; other site
709986008521	ABC-ATPase subunit interface; other site
709986008522	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
709986008523	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
709986008524	dimer interface [polypeptide binding]; other site
709986008525	conserved gate region; other site
709986008526	putative PBP binding loops; other site
709986008527	ABC-ATPase subunit interface; other site
709986008528	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
709986008529	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
709986008530	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
709986008531	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
709986008532	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
709986008533	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
709986008534	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
709986008535	S-adenosylmethionine binding site [chemical binding]; other site
709986008536	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
709986008537	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
709986008538	active site residue [active]
709986008539	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
709986008540	active site residue [active]
709986008541	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
709986008542	Putative methyltransferase; Region: Methyltransf_4; cl17290
709986008543	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
709986008544	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
709986008545	non-specific DNA interactions [nucleotide binding]; other site
709986008546	DNA binding site [nucleotide binding]
709986008547	sequence specific DNA binding site [nucleotide binding]; other site
709986008548	putative cAMP binding site [chemical binding]; other site
709986008549	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
709986008550	substrate binding site [chemical binding]; other site
709986008551	ATP binding site [chemical binding]; other site
709986008552	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
709986008553	RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248
709986008554	ATP binding site [chemical binding]; other site
709986008555	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
709986008556	NMT1/THI5 like; Region: NMT1; pfam09084
709986008557	substrate binding pocket [chemical binding]; other site
709986008558	membrane-bound complex binding site; other site
709986008559	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
709986008560	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
709986008561	homotrimer interaction site [polypeptide binding]; other site
709986008562	zinc binding site [ion binding]; other site
709986008563	CDP-binding sites; other site
709986008564	Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078
709986008565	TM2 domain; Region: TM2; pfam05154
709986008566	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
709986008567	active site
709986008568	catalytic residues [active]
709986008569	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
709986008570	active site
709986008571	catalytic residues [active]
709986008572	Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; cl01017
709986008573	Predicted membrane protein [Function unknown]; Region: COG3462
709986008574	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
709986008575	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986008576	active site
709986008577	phosphorylation site [posttranslational modification]
709986008578	intermolecular recognition site; other site
709986008579	dimerization interface [polypeptide binding]; other site
709986008580	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
709986008581	DNA binding site [nucleotide binding]
709986008582	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
709986008583	dimerization interface [polypeptide binding]; other site
709986008584	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
709986008585	dimer interface [polypeptide binding]; other site
709986008586	phosphorylation site [posttranslational modification]
709986008587	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986008588	ATP binding site [chemical binding]; other site
709986008589	Mg2+ binding site [ion binding]; other site
709986008590	G-X-G motif; other site
709986008591	Methyltransferase domain; Region: Methyltransf_23; pfam13489
709986008592	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
709986008593	S-adenosylmethionine binding site [chemical binding]; other site
709986008594	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
709986008595	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959
709986008596	NodB motif; other site
709986008597	putative active site [active]
709986008598	putative catalytic site [active]
709986008599	putative Zn binding site [ion binding]; other site
709986008600	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707
709986008601	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
709986008602	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
709986008603	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
709986008604	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
709986008605	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
709986008606	rod shape-determining protein MreB; Provisional; Region: PRK13927
709986008607	MreB and similar proteins; Region: MreB_like; cd10225
709986008608	nucleotide binding site [chemical binding]; other site
709986008609	Mg binding site [ion binding]; other site
709986008610	putative protofilament interaction site [polypeptide binding]; other site
709986008611	RodZ interaction site [polypeptide binding]; other site
709986008612	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
709986008613	Coenzyme A binding pocket [chemical binding]; other site
709986008614	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
709986008615	Major Facilitator Superfamily; Region: MFS_1; pfam07690
709986008616	putative substrate translocation pore; other site
709986008617	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
709986008618	Major Facilitator Superfamily; Region: MFS_1; pfam07690
709986008619	putative substrate translocation pore; other site
709986008620	Phospholipid methyltransferase; Region: PEMT; cl17370
709986008621	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
709986008622	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
709986008623	malonyl-CoA binding site [chemical binding]; other site
709986008624	dimer interface [polypeptide binding]; other site
709986008625	active site
709986008626	product binding site; other site
709986008627	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986008628	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986008629	metal binding site [ion binding]; metal-binding site
709986008630	active site
709986008631	I-site; other site
709986008632	GTP-binding protein YchF; Reviewed; Region: PRK09601
709986008633	YchF GTPase; Region: YchF; cd01900
709986008634	G1 box; other site
709986008635	GTP/Mg2+ binding site [chemical binding]; other site
709986008636	Switch I region; other site
709986008637	G2 box; other site
709986008638	Switch II region; other site
709986008639	G3 box; other site
709986008640	G4 box; other site
709986008641	G5 box; other site
709986008642	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
709986008643	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231; cd11544
709986008644	homodimer interface [polypeptide binding]; other site
709986008645	active site
709986008646	metal binding site [ion binding]; metal-binding site
709986008647	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
709986008648	active site
709986008649	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
709986008650	hypothetical protein; Reviewed; Region: PRK09588
709986008651	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
709986008652	dimer interface [polypeptide binding]; other site
709986008653	phosphorylation site [posttranslational modification]
709986008654	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986008655	ATP binding site [chemical binding]; other site
709986008656	Mg2+ binding site [ion binding]; other site
709986008657	G-X-G motif; other site
709986008658	Protein of unknown function (DUF1271); Region: DUF1271; pfam06902
709986008659	CDGSH-type zinc finger. Function unknown; Region: ZnF_CDGSH; smart00704
709986008660	metal-dependent hydrolase; Provisional; Region: PRK13291
709986008661	DinB superfamily; Region: DinB_2; pfam12867
709986008662	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
709986008663	homodimer interface [polypeptide binding]; other site
709986008664	metal binding site [ion binding]; metal-binding site
709986008665	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
709986008666	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
709986008667	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
709986008668	Walker A motif; other site
709986008669	ATP binding site [chemical binding]; other site
709986008670	Walker B motif; other site
709986008671	arginine finger; other site
709986008672	Peptidase family M41; Region: Peptidase_M41; pfam01434
709986008673	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
709986008674	Mechanosensitive ion channel; Region: MS_channel; pfam00924
709986008675	putative phosphate acyltransferase; Provisional; Region: PRK05331
709986008676	Uncharacterized conserved protein [Function unknown]; Region: COG1432
709986008677	LabA_like proteins; Region: LabA; cd10911
709986008678	putative metal binding site [ion binding]; other site
709986008679	Domain of unknown function (DUF309); Region: DUF309; cl00667
709986008680	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
709986008681	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
709986008682	catalytic residues [active]
709986008683	Serine hydrolase; Region: Ser_hydrolase; pfam06821
709986008684	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
709986008685	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
709986008686	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
709986008687	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
709986008688	alphaNTD - beta interaction site [polypeptide binding]; other site
709986008689	alphaNTD homodimer interface [polypeptide binding]; other site
709986008690	alphaNTD - beta' interaction site [polypeptide binding]; other site
709986008691	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
709986008692	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
709986008693	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
709986008694	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
709986008695	RNA binding surface [nucleotide binding]; other site
709986008696	30S ribosomal protein S11; Validated; Region: PRK05309
709986008697	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
709986008698	30S ribosomal protein S13; Region: bact_S13; TIGR03631
709986008699	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
709986008700	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
709986008701	rRNA binding site [nucleotide binding]; other site
709986008702	predicted 30S ribosome binding site; other site
709986008703	adenylate kinase; Provisional; Region: PRK14527
709986008704	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
709986008705	AMP-binding site [chemical binding]; other site
709986008706	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
709986008707	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
709986008708	SecY translocase; Region: SecY; pfam00344
709986008709	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
709986008710	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
709986008711	23S rRNA binding site [nucleotide binding]; other site
709986008712	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
709986008713	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
709986008714	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
709986008715	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
709986008716	5S rRNA interface [nucleotide binding]; other site
709986008717	23S rRNA interface [nucleotide binding]; other site
709986008718	L5 interface [polypeptide binding]; other site
709986008719	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
709986008720	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
709986008721	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
709986008722	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
709986008723	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
709986008724	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
709986008725	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
709986008726	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
709986008727	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
709986008728	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
709986008729	RNA binding site [nucleotide binding]; other site
709986008730	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
709986008731	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
709986008732	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
709986008733	23S rRNA interface [nucleotide binding]; other site
709986008734	putative translocon interaction site; other site
709986008735	signal recognition particle (SRP54) interaction site; other site
709986008736	L23 interface [polypeptide binding]; other site
709986008737	trigger factor interaction site; other site
709986008738	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
709986008739	23S rRNA interface [nucleotide binding]; other site
709986008740	5S rRNA interface [nucleotide binding]; other site
709986008741	putative antibiotic binding site [chemical binding]; other site
709986008742	L25 interface [polypeptide binding]; other site
709986008743	L27 interface [polypeptide binding]; other site
709986008744	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
709986008745	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
709986008746	G-X-X-G motif; other site
709986008747	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
709986008748	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
709986008749	protein-rRNA interface [nucleotide binding]; other site
709986008750	putative translocon binding site; other site
709986008751	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
709986008752	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
709986008753	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
709986008754	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
709986008755	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
709986008756	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
709986008757	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
709986008758	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
709986008759	elongation factor Tu; Reviewed; Region: PRK00049
709986008760	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
709986008761	G1 box; other site
709986008762	GEF interaction site [polypeptide binding]; other site
709986008763	GTP/Mg2+ binding site [chemical binding]; other site
709986008764	Switch I region; other site
709986008765	G2 box; other site
709986008766	G3 box; other site
709986008767	Switch II region; other site
709986008768	G4 box; other site
709986008769	G5 box; other site
709986008770	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
709986008771	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
709986008772	Antibiotic Binding Site [chemical binding]; other site
709986008773	elongation factor G; Reviewed; Region: PRK00007
709986008774	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
709986008775	G1 box; other site
709986008776	putative GEF interaction site [polypeptide binding]; other site
709986008777	GTP/Mg2+ binding site [chemical binding]; other site
709986008778	Switch I region; other site
709986008779	G2 box; other site
709986008780	G3 box; other site
709986008781	Switch II region; other site
709986008782	G4 box; other site
709986008783	G5 box; other site
709986008784	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
709986008785	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
709986008786	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
709986008787	30S ribosomal protein S7; Validated; Region: PRK05302
709986008788	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
709986008789	S17 interaction site [polypeptide binding]; other site
709986008790	S8 interaction site; other site
709986008791	16S rRNA interaction site [nucleotide binding]; other site
709986008792	streptomycin interaction site [chemical binding]; other site
709986008793	23S rRNA interaction site [nucleotide binding]; other site
709986008794	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
709986008795	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
709986008796	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
709986008797	NAD(P) binding site [chemical binding]; other site
709986008798	catalytic residues [active]
709986008799	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
709986008800	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
709986008801	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
709986008802	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
709986008803	putative ADP-binding pocket [chemical binding]; other site
709986008804	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
709986008805	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
709986008806	catalytic residues [active]
709986008807	pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14855
709986008808	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
709986008809	conserved repeat domain; Region: B_ant_repeat; TIGR01451
709986008810	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
709986008811	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
709986008812	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
709986008813	Domain of unknown function DUF11; Region: DUF11; cl17728
709986008814	Domain of unknown function DUF11; Region: DUF11; cl17728
709986008815	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719
709986008816	Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867
709986008817	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
709986008818	metal ion-dependent adhesion site (MIDAS); other site
709986008819	Predicted transcriptional regulators [Transcription]; Region: COG1695
709986008820	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
709986008821	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
709986008822	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
709986008823	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
709986008824	NAD(P) binding site [chemical binding]; other site
709986008825	homodimer interface [polypeptide binding]; other site
709986008826	substrate binding site [chemical binding]; other site
709986008827	active site
709986008828	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
709986008829	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
709986008830	NAD(P) binding site [chemical binding]; other site
709986008831	active site
709986008832	Bacterial sugar transferase; Region: Bac_transf; pfam02397
709986008833	putative glycosyl transferase; Provisional; Region: PRK10307
709986008834	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
709986008835	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
709986008836	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
709986008837	active site
709986008838	homodimer interface [polypeptide binding]; other site
709986008839	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
709986008840	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
709986008841	NAD(P) binding site [chemical binding]; other site
709986008842	active site
709986008843	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
709986008844	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
709986008845	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
709986008846	NAD(P) binding site [chemical binding]; other site
709986008847	homodimer interface [polypeptide binding]; other site
709986008848	substrate binding site [chemical binding]; other site
709986008849	active site
709986008850	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
709986008851	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
709986008852	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
709986008853	O-Antigen ligase; Region: Wzy_C; pfam04932
709986008854	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
709986008855	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
709986008856	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
709986008857	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
709986008858	putative ADP-binding pocket [chemical binding]; other site
709986008859	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
709986008860	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
709986008861	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
709986008862	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
709986008863	inhibitor-cofactor binding pocket; inhibition site
709986008864	pyridoxal 5'-phosphate binding site [chemical binding]; other site
709986008865	catalytic residue [active]
709986008866	WxcM-like, C-terminal; Region: FdtA; pfam05523
709986008867	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
709986008868	putative trimer interface [polypeptide binding]; other site
709986008869	putative CoA binding site [chemical binding]; other site
709986008870	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
709986008871	putative trimer interface [polypeptide binding]; other site
709986008872	putative CoA binding site [chemical binding]; other site
709986008873	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
709986008874	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
709986008875	substrate binding site; other site
709986008876	tetramer interface; other site
709986008877	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
709986008878	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
709986008879	NAD binding site [chemical binding]; other site
709986008880	substrate binding site [chemical binding]; other site
709986008881	homodimer interface [polypeptide binding]; other site
709986008882	active site
709986008883	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
709986008884	active site
709986008885	O-Antigen ligase; Region: Wzy_C; pfam04932
709986008886	Chain length determinant protein; Region: Wzz; cl15801
709986008887	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
709986008888	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
709986008889	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
709986008890	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
709986008891	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
709986008892	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
709986008893	active site
709986008894	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
709986008895	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
709986008896	Roadblock/LC7 domain; Region: Robl_LC7; pfam03259
709986008897	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
709986008898	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
709986008899	G1 box; other site
709986008900	GTP/Mg2+ binding site [chemical binding]; other site
709986008901	G2 box; other site
709986008902	Switch I region; other site
709986008903	G3 box; other site
709986008904	Switch II region; other site
709986008905	G4 box; other site
709986008906	G5 box; other site
709986008907	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
709986008908	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
709986008909	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
709986008910	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
709986008911	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
709986008912	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
709986008913	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
709986008914	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
709986008915	catalytic residues [active]
709986008916	AzlC protein; Region: AzlC; cl00570
709986008917	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
709986008918	DinB family; Region: DinB; cl17821
709986008919	DinB superfamily; Region: DinB_2; pfam12867
709986008920	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
709986008921	putative catalytic site [active]
709986008922	putative metal binding site [ion binding]; other site
709986008923	putative phosphate binding site [ion binding]; other site
709986008924	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
709986008925	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
709986008926	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
709986008927	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
709986008928	Protein of unknown function (DUF512); Region: DUF512; pfam04459
709986008929	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
709986008930	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_37; cd04696
709986008931	nudix motif; other site
709986008932	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
709986008933	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
709986008934	NAD(P) binding site [chemical binding]; other site
709986008935	active site
709986008936	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
709986008937	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
709986008938	minor groove reading motif; other site
709986008939	helix-hairpin-helix signature motif; other site
709986008940	substrate binding pocket [chemical binding]; other site
709986008941	active site
709986008942	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
709986008943	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
709986008944	ligand binding site [chemical binding]; other site
709986008945	flexible hinge region; other site
709986008946	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
709986008947	putative switch regulator; other site
709986008948	non-specific DNA interactions [nucleotide binding]; other site
709986008949	DNA binding site [nucleotide binding]
709986008950	sequence specific DNA binding site [nucleotide binding]; other site
709986008951	putative cAMP binding site [chemical binding]; other site
709986008952	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
709986008953	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
709986008954	ATP binding site [chemical binding]; other site
709986008955	putative Mg++ binding site [ion binding]; other site
709986008956	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
709986008957	nucleotide binding region [chemical binding]; other site
709986008958	ATP-binding site [chemical binding]; other site
709986008959	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
709986008960	replicative DNA helicase; Region: DnaB; TIGR00665
709986008961	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
709986008962	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
709986008963	Walker A motif; other site
709986008964	ATP binding site [chemical binding]; other site
709986008965	Walker B motif; other site
709986008966	DNA binding loops [nucleotide binding]
709986008967	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
709986008968	nudix motif; other site
709986008969	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986008970	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986008971	metal binding site [ion binding]; metal-binding site
709986008972	active site
709986008973	I-site; other site
709986008974	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
709986008975	short chain dehydrogenase; Provisional; Region: PRK12746
709986008976	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
709986008977	NAD(P) binding site [chemical binding]; other site
709986008978	active site
709986008979	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
709986008980	ATP cone domain; Region: ATP-cone; pfam03477
709986008981	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
709986008982	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
709986008983	TM-ABC transporter signature motif; other site
709986008984	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
709986008985	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
709986008986	TM-ABC transporter signature motif; other site
709986008987	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
709986008988	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
709986008989	putative ligand binding site [chemical binding]; other site
709986008990	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
709986008991	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
709986008992	Walker A/P-loop; other site
709986008993	ATP binding site [chemical binding]; other site
709986008994	Q-loop/lid; other site
709986008995	ABC transporter signature motif; other site
709986008996	Walker B; other site
709986008997	D-loop; other site
709986008998	H-loop/switch region; other site
709986008999	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
709986009000	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
709986009001	Walker A/P-loop; other site
709986009002	ATP binding site [chemical binding]; other site
709986009003	Q-loop/lid; other site
709986009004	ABC transporter signature motif; other site
709986009005	Walker B; other site
709986009006	D-loop; other site
709986009007	H-loop/switch region; other site
709986009008	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
709986009009	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
709986009010	putative acyl-acceptor binding pocket; other site
709986009011	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
709986009012	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
709986009013	putative RNA binding site [nucleotide binding]; other site
709986009014	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
709986009015	S-adenosylmethionine binding site [chemical binding]; other site
709986009016	Protein of unknown function (DUF3248); Region: DUF3248; pfam11609
709986009017	Protein of unknown function (DUF3809); Region: DUF3809; pfam12723
709986009018	metal-dependent hydrolase; Provisional; Region: PRK00685
709986009019	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
709986009020	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
709986009021	Catalytic domain of Protein Kinases; Region: PKc; cd00180
709986009022	active site
709986009023	ATP binding site [chemical binding]; other site
709986009024	substrate binding site [chemical binding]; other site
709986009025	activation loop (A-loop); other site
709986009026	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
709986009027	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
709986009028	motif II; other site
709986009029	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
709986009030	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
709986009031	Walker A motif; other site
709986009032	ATP binding site [chemical binding]; other site
709986009033	Walker B motif; other site
709986009034	arginine finger; other site
709986009035	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
709986009036	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
709986009037	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
709986009038	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
709986009039	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
709986009040	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
709986009041	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
709986009042	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
709986009043	phosphopeptide binding site; other site
709986009044	phage tail protein domain; Region: tail_TIGR02242
709986009045	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
709986009046	Catalytic domain of Protein Kinases; Region: PKc; cd00180
709986009047	active site
709986009048	ATP binding site [chemical binding]; other site
709986009049	substrate binding site [chemical binding]; other site
709986009050	activation loop (A-loop); other site
709986009051	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
709986009052	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
709986009053	phosphopeptide binding site; other site
709986009054	Rhs element Vgr protein; Region: vgr_GE; TIGR01646
709986009055	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
709986009056	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
709986009057	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
709986009058	Protein of unknown function (DUF3380); Region: DUF3380; pfam11860
709986009059	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
709986009060	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
709986009061	motif 1; other site
709986009062	active site
709986009063	motif 2; other site
709986009064	motif 3; other site
709986009065	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
709986009066	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
709986009067	Major Facilitator Superfamily; Region: MFS_1; pfam07690
709986009068	putative substrate translocation pore; other site
709986009069	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
709986009070	Ferritin-like domain; Region: Ferritin; pfam00210
709986009071	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
709986009072	dimerization interface [polypeptide binding]; other site
709986009073	DPS ferroxidase diiron center [ion binding]; other site
709986009074	ion pore; other site
709986009075	Domain of unknown function (DUF4385); Region: DUF4385; pfam14328
709986009076	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
709986009077	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
709986009078	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
709986009079	active site
709986009080	metal binding site [ion binding]; metal-binding site
709986009081	Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403
709986009082	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
709986009083	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
709986009084	active site
709986009085	Zn binding site [ion binding]; other site
709986009086	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
709986009087	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
709986009088	Protein of unknown function (DUF3105); Region: DUF3105; pfam11303
709986009089	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
709986009090	Thymidylate synthase complementing protein; Region: Thy1; pfam02511
709986009091	Amino acid permease; Region: AA_permease_2; pfam13520
709986009092	Predicted membrane protein [Function unknown]; Region: COG2311
709986009093	Protein of unknown function (DUF418); Region: DUF418; cl12135
709986009094	Protein of unknown function (DUF418); Region: DUF418; pfam04235
709986009095	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
709986009096	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
709986009097	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
709986009098	EVE domain; Region: EVE; cl00728
709986009099	periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038
709986009100	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
709986009101	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
709986009102	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
709986009103	Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253
709986009104	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
709986009105	active site
709986009106	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
709986009107	catalytic tetrad [active]
709986009108	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
709986009109	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
709986009110	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
709986009111	active site
709986009112	metal binding site [ion binding]; metal-binding site
709986009113	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
709986009114	Domain of unknown function DUF20; Region: UPF0118; pfam01594
709986009115	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
709986009116	non-specific DNA binding site [nucleotide binding]; other site
709986009117	salt bridge; other site
709986009118	sequence-specific DNA binding site [nucleotide binding]; other site
709986009119	PEGA domain; Region: PEGA; pfam08308
709986009120	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
709986009121	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
709986009122	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
709986009123	TM-ABC transporter signature motif; other site
709986009124	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
709986009125	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
709986009126	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
709986009127	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
709986009128	TM-ABC transporter signature motif; other site
709986009129	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
709986009130	active site
709986009131	multimer interface [polypeptide binding]; other site
709986009132	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
709986009133	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
709986009134	active site
709986009135	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
709986009136	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
709986009137	aspartate aminotransferase; Provisional; Region: PRK05764
709986009138	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
709986009139	pyridoxal 5'-phosphate binding site [chemical binding]; other site
709986009140	homodimer interface [polypeptide binding]; other site
709986009141	catalytic residue [active]
709986009142	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
709986009143	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
709986009144	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
709986009145	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
709986009146	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
709986009147	NAD(P) binding site [chemical binding]; other site
709986009148	LDH/MDH dimer interface [polypeptide binding]; other site
709986009149	substrate binding site [chemical binding]; other site
709986009150	OstA-like protein; Region: OstA; cl00844
709986009151	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934
709986009152	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
709986009153	active site
709986009154	Uncharacterized conserved protein [Function unknown]; Region: COG1739
709986009155	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
709986009156	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
709986009157	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
709986009158	dimer interface [polypeptide binding]; other site
709986009159	ADP-ribose binding site [chemical binding]; other site
709986009160	active site
709986009161	nudix motif; other site
709986009162	metal binding site [ion binding]; metal-binding site
709986009163	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
709986009164	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
709986009165	active site
709986009166	metal binding site [ion binding]; metal-binding site
709986009167	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
709986009168	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
709986009169	DNA protecting protein DprA; Region: dprA; TIGR00732
709986009170	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
709986009171	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
709986009172	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
709986009173	active site
709986009174	catalytic site [active]
709986009175	short chain dehydrogenase; Provisional; Region: PRK07576
709986009176	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
709986009177	NAD(P) binding site [chemical binding]; other site
709986009178	substrate binding site [chemical binding]; other site
709986009179	homotetramer interface [polypeptide binding]; other site
709986009180	active site
709986009181	homodimer interface [polypeptide binding]; other site
709986009182	enoyl-CoA hydratase; Provisional; Region: PRK06142
709986009183	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
709986009184	substrate binding site [chemical binding]; other site
709986009185	oxyanion hole (OAH) forming residues; other site
709986009186	trimer interface [polypeptide binding]; other site
709986009187	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
709986009188	Stage II sporulation protein; Region: SpoIID; pfam08486
709986009189	FAD dependent oxidoreductase; Region: DAO; pfam01266
709986009190	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
709986009191	threonine dehydratase; Reviewed; Region: PRK09224
709986009192	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
709986009193	tetramer interface [polypeptide binding]; other site
709986009194	pyridoxal 5'-phosphate binding site [chemical binding]; other site
709986009195	catalytic residue [active]
709986009196	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
709986009197	putative Ile/Val binding site [chemical binding]; other site
709986009198	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
709986009199	putative Ile/Val binding site [chemical binding]; other site
709986009200	menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701
709986009201	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
709986009202	Domain of unknown function (DUF4173); Region: DUF4173; pfam13777
709986009203	Arginine repressor [Transcription]; Region: ArgR; COG1438
709986009204	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
709986009205	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
709986009206	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
709986009207	Flavoprotein; Region: Flavoprotein; pfam02441
709986009208	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
709986009209	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
709986009210	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
709986009211	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
709986009212	Cl binding site [ion binding]; other site
709986009213	oligomer interface [polypeptide binding]; other site
709986009214	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
709986009215	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
709986009216	oligomer interface [polypeptide binding]; other site
709986009217	metal binding site [ion binding]; metal-binding site
709986009218	metal binding site [ion binding]; metal-binding site
709986009219	putative Cl binding site [ion binding]; other site
709986009220	aspartate ring; other site
709986009221	basic sphincter; other site
709986009222	hydrophobic gate; other site
709986009223	periplasmic entrance; other site
709986009224	CrcB-like protein; Region: CRCB; pfam02537
709986009225	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
709986009226	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
709986009227	generic binding surface II; other site
709986009228	generic binding surface I; other site
709986009229	TMAO/DMSO reductase; Reviewed; Region: PRK05363
709986009230	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
709986009231	Moco binding site; other site
709986009232	metal coordination site [ion binding]; other site
709986009233	Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043
709986009234	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
709986009235	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
709986009236	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
709986009237	GTPase CgtA; Reviewed; Region: obgE; PRK12297
709986009238	GTP1/OBG; Region: GTP1_OBG; pfam01018
709986009239	Obg GTPase; Region: Obg; cd01898
709986009240	G1 box; other site
709986009241	GTP/Mg2+ binding site [chemical binding]; other site
709986009242	Switch I region; other site
709986009243	G2 box; other site
709986009244	G3 box; other site
709986009245	Switch II region; other site
709986009246	G4 box; other site
709986009247	G5 box; other site
709986009248	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
709986009249	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
709986009250	Zn2+ binding site [ion binding]; other site
709986009251	Mg2+ binding site [ion binding]; other site
709986009252	Transcriptional regulator [Transcription]; Region: LytR; COG1316
709986009253	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
709986009254	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
709986009255	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
709986009256	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
709986009257	putative metal binding site [ion binding]; other site
709986009258	Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110
709986009259	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
709986009260	putative metal binding site [ion binding]; other site
709986009261	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
709986009262	active site
709986009263	catalytic residues [active]
709986009264	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
709986009265	TPR motif; other site
709986009266	Tetratricopeptide repeat; Region: TPR_12; pfam13424
709986009267	binding surface
709986009268	Tetratricopeptide repeat; Region: TPR_12; pfam13424
709986009269	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
709986009270	binding surface
709986009271	TPR motif; other site
709986009272	Tetratricopeptide repeat; Region: TPR_12; pfam13424
709986009273	Tetratricopeptide repeat; Region: TPR_12; pfam13424
709986009274	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
709986009275	Zn2+ binding site [ion binding]; other site
709986009276	Mg2+ binding site [ion binding]; other site
709986009277	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986009278	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986009279	metal binding site [ion binding]; metal-binding site
709986009280	active site
709986009281	I-site; other site
709986009282	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
709986009283	uncharacterized ygcE-like proteins; Region: FGGY_ygcE_like; cd07779
709986009284	putative N- and C-terminal domain interface [polypeptide binding]; other site
709986009285	putative active site [active]
709986009286	MgATP binding site [chemical binding]; other site
709986009287	catalytic site [active]
709986009288	metal binding site [ion binding]; metal-binding site
709986009289	putative carbohydrate binding site [chemical binding]; other site
709986009290	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
709986009291	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
709986009292	FAD binding domain; Region: FAD_binding_4; pfam01565
709986009293	fatty acid metabolism regulator; Provisional; Region: PRK04984
709986009294	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
709986009295	DNA-binding site [nucleotide binding]; DNA binding site
709986009296	FadR C-terminal domain; Region: FadR_C; pfam07840
709986009297	Cellulose binding domain; Region: CBM_2; cl17741
709986009298	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
709986009299	GH18 domain of Chitinase D (ChiD).  ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins.  The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871
709986009300	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
709986009301	putative active site [active]
709986009302	cyanophycin synthetase; Provisional; Region: PRK14016
709986009303	ATP-grasp domain; Region: ATP-grasp_4; cl17255
709986009304	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
709986009305	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
709986009306	Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and  L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635
709986009307	active site
709986009308	dimer interface [polypeptide binding]; other site
709986009309	catalytic nucleophile [active]
709986009310	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
709986009311	proposed catalytic triad [active]
709986009312	active site nucleophile [active]
709986009313	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
709986009314	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
709986009315	active site
709986009316	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
709986009317	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
709986009318	FeS/SAM binding site; other site
709986009319	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
709986009320	Ligand Binding Site [chemical binding]; other site
709986009321	Predicted membrane protein (DUF2243); Region: DUF2243; cl01783
709986009322	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
709986009323	Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947
709986009324	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299
709986009325	heme binding pocket [chemical binding]; other site
709986009326	heme ligand [chemical binding]; other site
709986009327	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
709986009328	GAF domain; Region: GAF; pfam01590
709986009329	Phytochrome region; Region: PHY; pfam00360
709986009330	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986009331	ATP binding site [chemical binding]; other site
709986009332	Mg2+ binding site [ion binding]; other site
709986009333	G-X-G motif; other site
709986009334	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
709986009335	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986009336	active site
709986009337	phosphorylation site [posttranslational modification]
709986009338	intermolecular recognition site; other site
709986009339	dimerization interface [polypeptide binding]; other site
709986009340	Protein of unknown function (DUF2983); Region: DUF2983; pfam11202
709986009341	mannosyl-3-phosphoglycerate phosphatase family; Region: HAD-SF-IIB-MPGP; TIGR01486
709986009342	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
709986009343	active site
709986009344	Protein of unknown function (DUF3706); Region: DUF3706; pfam12500
709986009345	carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767
709986009346	ATP-grasp domain; Region: ATP-grasp_4; cl17255
709986009347	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
709986009348	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
709986009349	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
709986009350	DNA binding residues [nucleotide binding]
709986009351	Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056
709986009352	Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947
709986009353	Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372
709986009354	Protein of unknown function (DUF790); Region: DUF790; pfam05626
709986009355	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
709986009356	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
709986009357	ATP binding site [chemical binding]; other site
709986009358	putative Mg++ binding site [ion binding]; other site
709986009359	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
709986009360	nucleotide binding region [chemical binding]; other site
709986009361	ATP-binding site [chemical binding]; other site
709986009362	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
709986009363	dimanganese center [ion binding]; other site
709986009364	GAF domain; Region: GAF; pfam01590
709986009365	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
709986009366	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986009367	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986009368	metal binding site [ion binding]; metal-binding site
709986009369	active site
709986009370	I-site; other site
709986009371	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
709986009372	FeS/SAM binding site; other site
709986009373	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
709986009374	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
709986009375	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
709986009376	active site
709986009377	DNA binding site [nucleotide binding]
709986009378	Int/Topo IB signature motif; other site
709986009379	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
709986009380	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
709986009381	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
709986009382	ATP-grasp domain; Region: ATP-grasp_4; cl17255
709986009383	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
709986009384	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
709986009385	substrate binding site [chemical binding]; other site
709986009386	ATP binding site [chemical binding]; other site
709986009387	YceG-like family; Region: YceG; pfam02618
709986009388	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
709986009389	dimerization interface [polypeptide binding]; other site
709986009390	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
709986009391	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
709986009392	Walker A/P-loop; other site
709986009393	ATP binding site [chemical binding]; other site
709986009394	Q-loop/lid; other site
709986009395	ABC transporter signature motif; other site
709986009396	Walker B; other site
709986009397	D-loop; other site
709986009398	H-loop/switch region; other site
709986009399	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
709986009400	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
709986009401	ABC-ATPase subunit  interface; other site
709986009402	dimer interface [polypeptide binding]; other site
709986009403	putative PBP binding regions; other site
709986009404	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
709986009405	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
709986009406	putative binding site residues; other site
709986009407	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
709986009408	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
709986009409	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
709986009410	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
709986009411	Predicted amidohydrolase [General function prediction only]; Region: COG0388
709986009412	putative active site [active]
709986009413	catalytic triad [active]
709986009414	putative dimer interface [polypeptide binding]; other site
709986009415	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
709986009416	Coenzyme A binding pocket [chemical binding]; other site
709986009417	conserved hypothetical protein, steroid delta-isomerase-related; Region: TIGR02096
709986009418	hypothetical protein; Provisional; Region: PRK02395
709986009419	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
709986009420	putative active site [active]
709986009421	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
709986009422	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
709986009423	putative active site [active]
709986009424	M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896
709986009425	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
709986009426	putative metal binding site [ion binding]; other site
709986009427	pyridoxamine kinase; Validated; Region: PRK05756
709986009428	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
709986009429	pyridoxal binding site [chemical binding]; other site
709986009430	dimer interface [polypeptide binding]; other site
709986009431	ATP binding site [chemical binding]; other site
709986009432	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
709986009433	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
709986009434	Peptidase S8 family domain, uncharacterized subfamily 5; Region: Peptidases_S8_5; cd07489
709986009435	active site
709986009436	catalytic triad [active]
709986009437	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
709986009438	putative integrin binding motif; other site
709986009439	PA/protease domain interface [polypeptide binding]; other site
709986009440	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
709986009441	catalytic residues [active]
709986009442	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
709986009443	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
709986009444	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
709986009445	active site
709986009446	catalytic residues [active]
709986009447	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
709986009448	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
709986009449	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
709986009450	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
709986009451	putative acyl-acceptor binding pocket; other site
709986009452	Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283
709986009453	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
709986009454	CMP-binding site; other site
709986009455	The sites determining sugar specificity; other site
709986009456	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
709986009457	active site
709986009458	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
709986009459	active site
709986009460	Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278
709986009461	enoyl-CoA hydratase; Provisional; Region: PRK08140
709986009462	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
709986009463	substrate binding site [chemical binding]; other site
709986009464	oxyanion hole (OAH) forming residues; other site
709986009465	trimer interface [polypeptide binding]; other site
709986009466	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
709986009467	binding surface
709986009468	Tetratricopeptide repeat; Region: TPR_12; pfam13424
709986009469	TPR motif; other site
709986009470	Tetratricopeptide repeat; Region: TPR_12; pfam13424
709986009471	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
709986009472	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
709986009473	metal binding site [ion binding]; metal-binding site
709986009474	active site
709986009475	I-site; other site
709986009476	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
709986009477	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
709986009478	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
709986009479	HD domain; Region: HD; pfam01966
709986009480	N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317
709986009481	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
709986009482	active site
709986009483	octamer interface [polypeptide binding]; other site
709986009484	Uncharacterized conserved protein [Function unknown]; Region: COG3375
709986009485	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
709986009486	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
709986009487	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
709986009488	dimer interface [polypeptide binding]; other site
709986009489	active site
709986009490	acyl carrier protein; Provisional; Region: acpP; PRK00982
709986009491	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
709986009492	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
709986009493	NAD(P) binding site [chemical binding]; other site
709986009494	homotetramer interface [polypeptide binding]; other site
709986009495	homodimer interface [polypeptide binding]; other site
709986009496	active site
709986009497	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
709986009498	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
709986009499	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
709986009500	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
709986009501	dimer interface [polypeptide binding]; other site
709986009502	active site
709986009503	CoA binding pocket [chemical binding]; other site
709986009504	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
709986009505	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
709986009506	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
709986009507	protein binding site [polypeptide binding]; other site
709986009508	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
709986009509	putative active site pocket [active]
709986009510	dimerization interface [polypeptide binding]; other site
709986009511	putative catalytic residue [active]
709986009512	trigger factor; Region: tig; TIGR00115
709986009513	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
709986009514	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
709986009515	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
709986009516	Zn2+ binding site [ion binding]; other site
709986009517	Mg2+ binding site [ion binding]; other site
709986009518	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
709986009519	EamA-like transporter family; Region: EamA; pfam00892
709986009520	MOSC domain; Region: MOSC; pfam03473
709986009521	GTP-binding protein Der; Reviewed; Region: PRK00093
709986009522	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
709986009523	G1 box; other site
709986009524	GTP/Mg2+ binding site [chemical binding]; other site
709986009525	Switch I region; other site
709986009526	G2 box; other site
709986009527	Switch II region; other site
709986009528	G3 box; other site
709986009529	G4 box; other site
709986009530	G5 box; other site
709986009531	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
709986009532	G1 box; other site
709986009533	GTP/Mg2+ binding site [chemical binding]; other site
709986009534	Switch I region; other site
709986009535	G2 box; other site
709986009536	G3 box; other site
709986009537	Switch II region; other site
709986009538	G4 box; other site
709986009539	G5 box; other site
709986009540	Domain of unknown function (DUF4188); Region: DUF4188; pfam13826
709986009541	Predicted transcriptional regulators [Transcription]; Region: COG1695
709986009542	Transcriptional regulator PadR-like family; Region: PadR; cl17335
709986009543	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
709986009544	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
709986009545	FUN14 family; Region: FUN14; pfam04930
709986009546	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
709986009547	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
709986009548	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
709986009549	DNA binding residues [nucleotide binding]
709986009550	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
709986009551	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
709986009552	active site
709986009553	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
709986009554	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
709986009555	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
709986009556	catalytic loop [active]
709986009557	iron binding site [ion binding]; other site
709986009558	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
709986009559	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
709986009560	Predicted permeases [General function prediction only]; Region: COG0795
709986009561	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
709986009562	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
709986009563	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
709986009564	Beta-Casp domain; Region: Beta-Casp; smart01027
709986009565	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
709986009566	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
709986009567	Ligand Binding Site [chemical binding]; other site
709986009568	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
709986009569	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
709986009570	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
709986009571	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
709986009572	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
709986009573	tRNA; other site
709986009574	putative tRNA binding site [nucleotide binding]; other site
709986009575	putative NADP binding site [chemical binding]; other site
709986009576	Protein of unknown function (DUF418); Region: DUF418; cl12135
709986009577	Protein of unknown function (DUF418); Region: DUF418; pfam04235
709986009578	S-adenosylmethionine synthetase; Validated; Region: PRK05250
709986009579	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
709986009580	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
709986009581	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
709986009582	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
709986009583	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
709986009584	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
709986009585	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
709986009586	acyl-activating enzyme (AAE) consensus motif; other site
709986009587	AMP binding site [chemical binding]; other site
709986009588	active site
709986009589	CoA binding site [chemical binding]; other site
709986009590	Ferredoxin [Energy production and conversion]; Region: COG1146
709986009591	4Fe-4S binding domain; Region: Fer4; cl02805
709986009592	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
709986009593	active site
709986009594	Uncharacterized conserved protein [Function unknown]; Region: COG3339
709986009595	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
709986009596	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
709986009597	dimer interface [polypeptide binding]; other site
709986009598	phosphorylation site [posttranslational modification]
709986009599	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
709986009600	ATP binding site [chemical binding]; other site
709986009601	G-X-G motif; other site
709986009602	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
709986009603	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986009604	active site
709986009605	phosphorylation site [posttranslational modification]
709986009606	intermolecular recognition site; other site
709986009607	dimerization interface [polypeptide binding]; other site
709986009608	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
709986009609	DNA binding site [nucleotide binding]
709986009610	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
709986009611	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
709986009612	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
709986009613	Walker A/P-loop; other site
709986009614	ATP binding site [chemical binding]; other site
709986009615	Q-loop/lid; other site
709986009616	ABC transporter signature motif; other site
709986009617	Walker B; other site
709986009618	D-loop; other site
709986009619	H-loop/switch region; other site
709986009620	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
709986009621	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
709986009622	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
709986009623	Walker A/P-loop; other site
709986009624	ATP binding site [chemical binding]; other site
709986009625	Q-loop/lid; other site
709986009626	ABC transporter signature motif; other site
709986009627	Walker B; other site
709986009628	D-loop; other site
709986009629	H-loop/switch region; other site
709986009630	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294
709986009631	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
709986009632	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
709986009633	hydroxyglutarate oxidase; Provisional; Region: PRK11728
709986009634	Protein of unknown function (DUF422); Region: DUF422; cl00991
709986009635	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
709986009636	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
709986009637	putative acyl-acceptor binding pocket; other site
709986009638	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
709986009639	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
709986009640	active site
709986009641	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
709986009642	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
709986009643	Cytochrome P450; Region: p450; cl12078
709986009644	DinB superfamily; Region: DinB_2; pfam12867
709986009645	DinB family; Region: DinB; cl17821
709986009646	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
709986009647	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
709986009648	Predicted flavoprotein [General function prediction only]; Region: COG0431
709986009649	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
709986009650	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
709986009651	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
709986009652	dimer interface [polypeptide binding]; other site
709986009653	putative functional site; other site
709986009654	putative MPT binding site; other site
709986009655	polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075
709986009656	Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423
709986009657	active site
709986009658	metal binding site [ion binding]; metal-binding site
709986009659	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
709986009660	active site
709986009661	catalytic site [active]
709986009662	substrate binding site [chemical binding]; other site
709986009663	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
709986009664	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
709986009665	RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623
709986009666	3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074
709986009667	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
709986009668	S-adenosylmethionine binding site [chemical binding]; other site
709986009669	adhesin; Provisional; Region: PRK09752
709986009670	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
709986009671	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
709986009672	domain interfaces; other site
709986009673	active site
709986009674	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
709986009675	classical (c) SDRs; Region: SDR_c; cd05233
709986009676	NAD(P) binding site [chemical binding]; other site
709986009677	active site
709986009678	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
709986009679	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
709986009680	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
709986009681	catalytic residue [active]
709986009682	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
709986009683	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
709986009684	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
709986009685	active site
709986009686	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
709986009687	PEGA domain; Region: PEGA; pfam08308
709986009688	PEGA domain; Region: PEGA; pfam08308
709986009689	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
709986009690	TPR motif; other site
709986009691	binding surface
709986009692	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
709986009693	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
709986009694	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
709986009695	homotrimer interaction site [polypeptide binding]; other site
709986009696	putative active site [active]
709986009697	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
709986009698	active site
709986009699	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
709986009700	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
709986009701	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
709986009702	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
709986009703	dimer interface [polypeptide binding]; other site
709986009704	motif 1; other site
709986009705	active site
709986009706	motif 2; other site
709986009707	motif 3; other site
709986009708	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
709986009709	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
709986009710	putative tRNA-binding site [nucleotide binding]; other site
709986009711	B3/4 domain; Region: B3_4; pfam03483
709986009712	tRNA synthetase B5 domain; Region: B5; smart00874
709986009713	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
709986009714	dimer interface [polypeptide binding]; other site
709986009715	motif 1; other site
709986009716	motif 3; other site
709986009717	motif 2; other site
709986009718	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
709986009719	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
709986009720	Peptidase family M23; Region: Peptidase_M23; pfam01551
709986009721	Response regulator receiver domain; Region: Response_reg; pfam00072
709986009722	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986009723	active site
709986009724	phosphorylation site [posttranslational modification]
709986009725	intermolecular recognition site; other site
709986009726	dimerization interface [polypeptide binding]; other site
709986009727	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
709986009728	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
709986009729	active site
709986009730	phosphorylation site [posttranslational modification]
709986009731	intermolecular recognition site; other site
709986009732	dimerization interface [polypeptide binding]; other site
709986009733	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
709986009734	DNA binding site [nucleotide binding]
709986009735	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
709986009736	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
709986009737	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
709986009738	Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720
709986009739	VanW like protein; Region: VanW; pfam04294
709986009740	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
709986009741	ParB-like nuclease domain; Region: ParB; smart00470
709986009742	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
709986009743	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
709986009744	P-loop; other site
709986009745	Magnesium ion binding site [ion binding]; other site
709986009746	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
709986009747	Magnesium ion binding site [ion binding]; other site
709986009748	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
709986009749	S-adenosylmethionine binding site [chemical binding]; other site
709986009750	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
709986009751	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
709986009752	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
709986009753	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932