-- dump date   	20140619_060457
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
937777000001	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
937777000002	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
937777000003	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
937777000004	P-loop; other site
937777000005	Magnesium ion binding site [ion binding]; other site
937777000006	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
937777000007	ParB-like nuclease domain; Region: ParB; smart00470
937777000008	Dienelactone hydrolase family; Region: DLH; pfam01738
937777000009	Replication initiator protein A; Region: RPA; cl17860
937777000010	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
937777000011	Transposase; Region: HTH_Tnp_1; pfam01527
937777000012	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
937777000013	NAD(P) binding site [chemical binding]; other site
937777000014	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
937777000015	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
937777000016	intersubunit interface [polypeptide binding]; other site
937777000017	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
937777000018	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
937777000019	ABC-ATPase subunit  interface; other site
937777000020	dimer interface [polypeptide binding]; other site
937777000021	putative PBP binding regions; other site
937777000022	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
937777000023	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
937777000024	ABC-ATPase subunit  interface; other site
937777000025	dimer interface [polypeptide binding]; other site
937777000026	putative PBP binding regions; other site
937777000027	iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411
937777000028	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
937777000029	siderophore binding site; other site
937777000030	iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411
937777000031	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
937777000032	siderophore binding site; other site
937777000033	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
937777000034	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
937777000035	Walker A/P-loop; other site
937777000036	ATP binding site [chemical binding]; other site
937777000037	Q-loop/lid; other site
937777000038	ABC transporter signature motif; other site
937777000039	Walker B; other site
937777000040	D-loop; other site
937777000041	H-loop/switch region; other site
937777000042	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
937777000043	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
937777000044	Transcriptional regulators [Transcription]; Region: PurR; COG1609
937777000045	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
937777000046	ligand binding site [chemical binding]; other site
937777000047	dimerization interface [polypeptide binding]; other site
937777000048	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
937777000049	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
937777000050	metal binding site [ion binding]; metal-binding site
937777000051	active site
937777000052	I-site; other site
937777000053	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
937777000054	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
937777000055	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
937777000056	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777000057	dimer interface [polypeptide binding]; other site
937777000058	phosphorylation site [posttranslational modification]
937777000059	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777000060	ATP binding site [chemical binding]; other site
937777000061	Mg2+ binding site [ion binding]; other site
937777000062	G-X-G motif; other site
937777000063	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
937777000064	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
937777000065	catalytic nucleophile [active]
937777000066	Zn(II)-responsive transcriptional regulator; Region: ZntR; TIGR02043
937777000067	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
937777000068	DNA binding residues [nucleotide binding]
937777000069	dimer interface [polypeptide binding]; other site
937777000070	metal binding site [ion binding]; metal-binding site
937777000071	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
937777000072	dimerization interface [polypeptide binding]; other site
937777000073	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
937777000074	Coenzyme A binding pocket [chemical binding]; other site
937777000075	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
937777000076	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
937777000077	metal-binding site [ion binding]
937777000078	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
937777000079	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
937777000080	metal-binding site [ion binding]
937777000081	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
937777000082	Soluble P-type ATPase [General function prediction only]; Region: COG4087
937777000083	SnoaL-like domain; Region: SnoaL_2; pfam12680
937777000084	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
937777000085	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
937777000086	catalytic residues [active]
937777000087	Protein of unknown function (DUF1684); Region: DUF1684; pfam07920
937777000088	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
937777000089	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
937777000090	metal-binding site [ion binding]
937777000091	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
937777000092	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
937777000093	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
937777000094	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
937777000095	ligand binding site [chemical binding]; other site
937777000096	flexible hinge region; other site
937777000097	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
937777000098	putative switch regulator; other site
937777000099	non-specific DNA interactions [nucleotide binding]; other site
937777000100	DNA binding site [nucleotide binding]
937777000101	sequence specific DNA binding site [nucleotide binding]; other site
937777000102	putative cAMP binding site [chemical binding]; other site
937777000103	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
937777000104	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
937777000105	ligand binding site [chemical binding]; other site
937777000106	flexible hinge region; other site
937777000107	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
937777000108	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
937777000109	thiamine pyrophosphate protein; Provisional; Region: PRK08273
937777000110	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
937777000111	PYR/PP interface [polypeptide binding]; other site
937777000112	dimer interface [polypeptide binding]; other site
937777000113	tetramer interface [polypeptide binding]; other site
937777000114	TPP binding site [chemical binding]; other site
937777000115	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
937777000116	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
937777000117	TPP-binding site [chemical binding]; other site
937777000118	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
937777000119	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_3; cd03328
937777000120	putative active site pocket [active]
937777000121	putative metal binding site [ion binding]; other site
937777000122	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
937777000123	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
937777000124	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
937777000125	Protein of unknown function (DUF1440); Region: DUF1440; cl01380
937777000126	PRC-barrel domain; Region: PRC; pfam05239
937777000127	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
937777000128	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
937777000129	EthD domain; Region: EthD; cl17553
937777000130	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
937777000131	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
937777000132	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
937777000133	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
937777000134	catalytic residues [active]
937777000135	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
937777000136	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
937777000137	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
937777000138	Uncharacterized conserved protein [Function unknown]; Region: COG2128
937777000139	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
937777000140	YceI-like domain; Region: YceI; smart00867
937777000141	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
937777000142	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
937777000143	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
937777000144	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
937777000145	ligand binding site [chemical binding]; other site
937777000146	flexible hinge region; other site
937777000147	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
937777000148	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
937777000149	Isochorismatase family; Region: Isochorismatase; pfam00857
937777000150	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
937777000151	catalytic triad [active]
937777000152	conserved cis-peptide bond; other site
937777000153	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
937777000154	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777000155	dimer interface [polypeptide binding]; other site
937777000156	conserved gate region; other site
937777000157	putative PBP binding loops; other site
937777000158	ABC-ATPase subunit interface; other site
937777000159	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777000160	dimer interface [polypeptide binding]; other site
937777000161	conserved gate region; other site
937777000162	putative PBP binding loops; other site
937777000163	ABC-ATPase subunit interface; other site
937777000164	active site
937777000165	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
937777000166	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
937777000167	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
937777000168	MarR family; Region: MarR_2; pfam12802
937777000169	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
937777000170	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
937777000171	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
937777000172	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
937777000173	nucleotide binding site [chemical binding]; other site
937777000174	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
937777000175	Protein of unknown function, DUF608; Region: DUF608; pfam04685
937777000176	Alkaline and neutral invertase; Region: Glyco_hydro_100; cl17340
937777000177	peptidase; Reviewed; Region: PRK13004
937777000178	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
937777000179	metal binding site [ion binding]; metal-binding site
937777000180	Homeodomain-like domain; Region: HTH_23; pfam13384
937777000181	Winged helix-turn helix; Region: HTH_29; pfam13551
937777000182	Homeodomain-like domain; Region: HTH_32; pfam13565
937777000183	DDE superfamily endonuclease; Region: DDE_3; pfam13358
937777000184	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
937777000185	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
937777000186	active site
937777000187	succinic semialdehyde dehydrogenase; Region: PLN02278
937777000188	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
937777000189	tetramerization interface [polypeptide binding]; other site
937777000190	NAD(P) binding site [chemical binding]; other site
937777000191	catalytic residues [active]
937777000192	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
937777000193	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
937777000194	DNA-binding site [nucleotide binding]; DNA binding site
937777000195	FCD domain; Region: FCD; pfam07729
937777000196	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
937777000197	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
937777000198	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777000199	putative PBP binding loops; other site
937777000200	dimer interface [polypeptide binding]; other site
937777000201	ABC-ATPase subunit interface; other site
937777000202	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
937777000203	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777000204	dimer interface [polypeptide binding]; other site
937777000205	conserved gate region; other site
937777000206	putative PBP binding loops; other site
937777000207	ABC-ATPase subunit interface; other site
937777000208	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
937777000209	hexamer (dimer of trimers) interface [polypeptide binding]; other site
937777000210	substrate binding site [chemical binding]; other site
937777000211	trimer interface [polypeptide binding]; other site
937777000212	Mn binding site [ion binding]; other site
937777000213	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
937777000214	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
937777000215	substrate binding site [chemical binding]; other site
937777000216	ATP binding site [chemical binding]; other site
937777000217	Class I aldolases; Region: Aldolase_Class_I; cl17187
937777000218	putative alpha-glucosidase; Provisional; Region: PRK10658
937777000219	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
937777000220	Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055
937777000221	active site
937777000222	catalytic site [active]
937777000223	Predicted permeases [General function prediction only]; Region: COG0679
937777000224	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
937777000225	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
937777000226	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
937777000227	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
937777000228	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
937777000229	putative active site [active]
937777000230	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
937777000231	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
937777000232	active site
937777000233	catalytic residues [active]
937777000234	DNA binding site [nucleotide binding]
937777000235	Int/Topo IB signature motif; other site
937777000236	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
937777000237	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
937777000238	P-loop; other site
937777000239	Magnesium ion binding site [ion binding]; other site
937777000240	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
937777000241	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
937777000242	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
937777000243	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
937777000244	catalytic residue [active]
937777000245	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
937777000246	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
937777000247	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
937777000248	DNA binding residues [nucleotide binding]
937777000249	dimerization interface [polypeptide binding]; other site
937777000250	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
937777000251	Transposase; Region: DEDD_Tnp_IS110; pfam01548
937777000252	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
937777000253	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
937777000254	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
937777000255	putative transposase OrfB; Reviewed; Region: PHA02517
937777000256	HTH-like domain; Region: HTH_21; pfam13276
937777000257	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
937777000258	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
937777000259	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
937777000260	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
937777000261	Transcriptional regulator [Transcription]; Region: IclR; COG1414
937777000262	Bacterial transcriptional regulator; Region: IclR; pfam01614
937777000263	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
937777000264	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
937777000265	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
937777000266	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777000267	dimer interface [polypeptide binding]; other site
937777000268	conserved gate region; other site
937777000269	ABC-ATPase subunit interface; other site
937777000270	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
937777000271	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777000272	dimer interface [polypeptide binding]; other site
937777000273	conserved gate region; other site
937777000274	putative PBP binding loops; other site
937777000275	ABC-ATPase subunit interface; other site
937777000276	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
937777000277	active site
937777000278	Zn binding site [ion binding]; other site
937777000279	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
937777000280	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
937777000281	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
937777000282	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
937777000283	putative active site [active]
937777000284	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
937777000285	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
937777000286	ATP binding site [chemical binding]; other site
937777000287	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
937777000288	putative Mg++ binding site [ion binding]; other site
937777000289	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
937777000290	nucleotide binding region [chemical binding]; other site
937777000291	ATP-binding site [chemical binding]; other site
937777000292	Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372
937777000293	Protein of unknown function (DUF790); Region: DUF790; pfam05626
937777000294	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
937777000295	DNA topoisomerase I, bacterial; Region: topA_bact; TIGR01051
937777000296	active site
937777000297	interdomain interaction site; other site
937777000298	putative metal-binding site [ion binding]; other site
937777000299	nucleotide binding site [chemical binding]; other site
937777000300	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
937777000301	domain I; other site
937777000302	DNA binding groove [nucleotide binding]
937777000303	phosphate binding site [ion binding]; other site
937777000304	domain II; other site
937777000305	domain III; other site
937777000306	nucleotide binding site [chemical binding]; other site
937777000307	catalytic site [active]
937777000308	domain IV; other site
937777000309	Beta-lactamase; Region: Beta-lactamase; pfam00144
937777000310	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
937777000311	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
937777000312	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
937777000313	non-specific DNA binding site [nucleotide binding]; other site
937777000314	salt bridge; other site
937777000315	sequence-specific DNA binding site [nucleotide binding]; other site
937777000316	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
937777000317	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
937777000318	Excalibur calcium-binding domain; Region: Excalibur; smart00894
937777000319	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
937777000320	active site
937777000321	NTP binding site [chemical binding]; other site
937777000322	metal binding triad [ion binding]; metal-binding site
937777000323	GIY-YIG type nucleases (URI domain); Region: GIYc; smart00465
937777000324	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
937777000325	Transposase; Region: HTH_Tnp_1; pfam01527
937777000326	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
937777000327	Coenzyme A binding pocket [chemical binding]; other site
937777000328	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
937777000329	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
937777000330	Transposase; Region: DDE_Tnp_ISL3; pfam01610
937777000331	Helix-turn-helix domain; Region: HTH_28; pfam13518
937777000332	Transposase; Region: DDE_Tnp_ISL3; pfam01610
937777000333	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
937777000334	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777000335	ATP binding site [chemical binding]; other site
937777000336	Mg2+ binding site [ion binding]; other site
937777000337	G-X-G motif; other site
937777000338	DDE superfamily endonuclease; Region: DDE_5; pfam13546
937777000339	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
937777000340	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
937777000341	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
937777000342	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
937777000343	putative active site [active]
937777000344	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
937777000345	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
937777000346	active site
937777000347	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
937777000348	NlpC/P60 family; Region: NLPC_P60; cl17555
937777000349	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
937777000350	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
937777000351	oligomer interface [polypeptide binding]; other site
937777000352	active site
937777000353	metal binding site [ion binding]; metal-binding site
937777000354	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
937777000355	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777000356	dimer interface [polypeptide binding]; other site
937777000357	conserved gate region; other site
937777000358	putative PBP binding loops; other site
937777000359	ABC-ATPase subunit interface; other site
937777000360	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
937777000361	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777000362	dimer interface [polypeptide binding]; other site
937777000363	conserved gate region; other site
937777000364	putative PBP binding loops; other site
937777000365	ABC-ATPase subunit interface; other site
937777000366	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
937777000367	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
937777000368	Homeodomain-like domain; Region: HTH_23; pfam13384
937777000369	Winged helix-turn helix; Region: HTH_29; pfam13551
937777000370	Homeodomain-like domain; Region: HTH_32; pfam13565
937777000371	DDE superfamily endonuclease; Region: DDE_3; pfam13358
937777000372	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
937777000373	Transposase; Region: DEDD_Tnp_IS110; pfam01548
937777000374	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
937777000375	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
937777000376	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
937777000377	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
937777000378	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
937777000379	non-specific DNA binding site [nucleotide binding]; other site
937777000380	salt bridge; other site
937777000381	sequence-specific DNA binding site [nucleotide binding]; other site
937777000382	Domain of unknown function (DUF3846); Region: DUF3846; pfam12957
937777000383	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
937777000384	non-specific DNA binding site [nucleotide binding]; other site
937777000385	salt bridge; other site
937777000386	sequence-specific DNA binding site [nucleotide binding]; other site
937777000387	SEFIR domain; Region: SEFIR; pfam08357
937777000388	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
937777000389	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
937777000390	Transposase; Region: HTH_Tnp_1; pfam01527
937777000391	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
937777000392	putative transposase OrfB; Reviewed; Region: PHA02517
937777000393	HTH-like domain; Region: HTH_21; pfam13276
937777000394	Integrase core domain; Region: rve; pfam00665
937777000395	Integrase core domain; Region: rve_3; pfam13683
937777000396	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
937777000397	putative transposase OrfB; Reviewed; Region: PHA02517
937777000398	HTH-like domain; Region: HTH_21; pfam13276
937777000399	Integrase core domain; Region: rve; pfam00665
937777000400	Integrase core domain; Region: rve_3; pfam13683
937777000401	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
937777000402	DNA-binding interface [nucleotide binding]; DNA binding site
937777000403	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
937777000404	sugar binding site [chemical binding]; other site
937777000405	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
937777000406	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
937777000407	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
937777000408	catalytic residue [active]
937777000409	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651
937777000410	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like3; cd08013
937777000411	metal binding site [ion binding]; metal-binding site
937777000412	putative dimer interface [polypeptide binding]; other site
937777000413	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
937777000414	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
937777000415	S-adenosylmethionine binding site [chemical binding]; other site
937777000416	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
937777000417	dimer interface [polypeptide binding]; other site
937777000418	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
937777000419	active site
937777000420	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
937777000421	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
937777000422	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777000423	dimer interface [polypeptide binding]; other site
937777000424	ABC-ATPase subunit interface; other site
937777000425	putative PBP binding loops; other site
937777000426	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
937777000427	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777000428	dimer interface [polypeptide binding]; other site
937777000429	conserved gate region; other site
937777000430	putative PBP binding loops; other site
937777000431	ABC-ATPase subunit interface; other site
937777000432	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518
937777000433	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
937777000434	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538
937777000435	PA/protease or protease-like domain interface [polypeptide binding]; other site
937777000436	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
937777000437	Peptidase family M28; Region: Peptidase_M28; pfam04389
937777000438	metal binding site [ion binding]; metal-binding site
937777000439	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
937777000440	Transcriptional regulator [Transcription]; Region: IclR; COG1414
937777000441	Bacterial transcriptional regulator; Region: IclR; pfam01614
937777000442	Uncharacterized conserved protein [Function unknown]; Region: COG3342
937777000443	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
937777000444	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
937777000445	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516
937777000446	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
937777000447	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777000448	dimer interface [polypeptide binding]; other site
937777000449	conserved gate region; other site
937777000450	putative PBP binding loops; other site
937777000451	ABC-ATPase subunit interface; other site
937777000452	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
937777000453	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
937777000454	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777000455	dimer interface [polypeptide binding]; other site
937777000456	conserved gate region; other site
937777000457	putative PBP binding loops; other site
937777000458	ABC-ATPase subunit interface; other site
937777000459	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
937777000460	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
937777000461	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
937777000462	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
937777000463	FAD binding domain; Region: FAD_binding_4; pfam01565
937777000464	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
937777000465	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
937777000466	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
937777000467	active site
937777000468	catalytic tetrad [active]
937777000469	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
937777000470	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
937777000471	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
937777000472	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
937777000473	Transposase; Region: HTH_Tnp_1; pfam01527
937777000474	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
937777000475	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
937777000476	active site
937777000477	catalytic residues [active]
937777000478	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
937777000479	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
937777000480	oligomer interface [polypeptide binding]; other site
937777000481	active site
937777000482	metal binding site [ion binding]; metal-binding site
937777000483	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
937777000484	putative substrate translocation pore; other site
937777000485	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
937777000486	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777000487	dimer interface [polypeptide binding]; other site
937777000488	conserved gate region; other site
937777000489	putative PBP binding loops; other site
937777000490	ABC-ATPase subunit interface; other site
937777000491	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
937777000492	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777000493	dimer interface [polypeptide binding]; other site
937777000494	conserved gate region; other site
937777000495	putative PBP binding loops; other site
937777000496	ABC-ATPase subunit interface; other site
937777000497	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
937777000498	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516
937777000499	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
937777000500	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
937777000501	DNA-binding site [nucleotide binding]; DNA binding site
937777000502	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
937777000503	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
937777000504	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
937777000505	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
937777000506	substrate binding site [chemical binding]; other site
937777000507	ATP binding site [chemical binding]; other site
937777000508	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
937777000509	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
937777000510	active site
937777000511	intersubunit interface [polypeptide binding]; other site
937777000512	catalytic residue [active]
937777000513	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
937777000514	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
937777000515	active site
937777000516	intersubunit interface [polypeptide binding]; other site
937777000517	catalytic residue [active]
937777000518	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
937777000519	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
937777000520	galactonate dehydratase; Provisional; Region: PRK14017
937777000521	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
937777000522	putative active site pocket [active]
937777000523	putative metal binding site [ion binding]; other site
937777000524	Transcriptional regulators [Transcription]; Region: FadR; COG2186
937777000525	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
937777000526	DNA-binding site [nucleotide binding]; DNA binding site
937777000527	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
937777000528	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
937777000529	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
937777000530	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
937777000531	DctM-like transporters; Region: DctM; pfam06808
937777000532	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
937777000533	putative dehydratase; Provisional; Region: PRK08211
937777000534	Dehydratase family; Region: ILVD_EDD; cl00340
937777000535	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
937777000536	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
937777000537	dimer interface [polypeptide binding]; other site
937777000538	NADP binding site [chemical binding]; other site
937777000539	catalytic residues [active]
937777000540	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
937777000541	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
937777000542	FAD binding domain; Region: FAD_binding_4; pfam01565
937777000543	Transcriptional regulators [Transcription]; Region: FadR; COG2186
937777000544	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
937777000545	DNA-binding site [nucleotide binding]; DNA binding site
937777000546	FCD domain; Region: FCD; pfam07729
937777000547	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
937777000548	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
937777000549	GAF domain; Region: GAF_3; pfam13492
937777000550	GAF domain; Region: GAF_3; pfam13492
937777000551	GAF domain; Region: GAF_2; pfam13185
937777000552	GAF domain; Region: GAF_3; pfam13492
937777000553	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
937777000554	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777000555	dimer interface [polypeptide binding]; other site
937777000556	phosphorylation site [posttranslational modification]
937777000557	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777000558	ATP binding site [chemical binding]; other site
937777000559	Mg2+ binding site [ion binding]; other site
937777000560	G-X-G motif; other site
937777000561	Response regulator receiver domain; Region: Response_reg; pfam00072
937777000562	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777000563	active site
937777000564	phosphorylation site [posttranslational modification]
937777000565	intermolecular recognition site; other site
937777000566	dimerization interface [polypeptide binding]; other site
937777000567	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
937777000568	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
937777000569	catalytic residues [active]
937777000570	catalytic nucleophile [active]
937777000571	Recombinase; Region: Recombinase; pfam07508
937777000572	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
937777000573	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
937777000574	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
937777000575	active site
937777000576	catalytic residues [active]
937777000577	Int/Topo IB signature motif; other site
937777000578	DNA binding site [nucleotide binding]
937777000579	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
937777000580	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
937777000581	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
937777000582	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
937777000583	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
937777000584	putative active site [active]
937777000585	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
937777000586	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014
937777000587	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
937777000588	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
937777000589	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
937777000590	active site
937777000591	catalytic residues [active]
937777000592	DNA binding site [nucleotide binding]
937777000593	Int/Topo IB signature motif; other site
937777000594	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
937777000595	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
937777000596	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
937777000597	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
937777000598	metal binding site [ion binding]; metal-binding site
937777000599	active site
937777000600	I-site; other site
937777000601	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
937777000602	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
937777000603	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
937777000604	metal-binding site [ion binding]
937777000605	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
937777000606	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
937777000607	motif II; other site
937777000608	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
937777000609	dimerization interface [polypeptide binding]; other site
937777000610	putative DNA binding site [nucleotide binding]; other site
937777000611	putative Zn2+ binding site [ion binding]; other site
937777000612	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
937777000613	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
937777000614	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
937777000615	Int/Topo IB signature motif; other site
937777000616	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
937777000617	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
937777000618	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
937777000619	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
937777000620	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
937777000621	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
937777000622	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
937777000623	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
937777000624	NAD binding site [chemical binding]; other site
937777000625	putative substrate binding site 2 [chemical binding]; other site
937777000626	putative substrate binding site 1 [chemical binding]; other site
937777000627	active site
937777000628	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
937777000629	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
937777000630	putative trimer interface [polypeptide binding]; other site
937777000631	putative CoA binding site [chemical binding]; other site
937777000632	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
937777000633	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
937777000634	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
937777000635	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
937777000636	active site
937777000637	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
937777000638	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
937777000639	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
937777000640	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
937777000641	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
937777000642	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
937777000643	GDP-mannose 4,6-dehydratase; Region: PLN02653
937777000644	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
937777000645	NADP-binding site; other site
937777000646	homotetramer interface [polypeptide binding]; other site
937777000647	substrate binding site [chemical binding]; other site
937777000648	homodimer interface [polypeptide binding]; other site
937777000649	active site
937777000650	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
937777000651	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
937777000652	NADP binding site [chemical binding]; other site
937777000653	active site
937777000654	putative substrate binding site [chemical binding]; other site
937777000655	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
937777000656	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
937777000657	Substrate binding site; other site
937777000658	Cupin domain; Region: Cupin_2; cl17218
937777000659	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
937777000660	O-Antigen ligase; Region: Wzy_C; pfam04932
937777000661	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
937777000662	TPR motif; other site
937777000663	TPR repeat; Region: TPR_11; pfam13414
937777000664	binding surface
937777000665	Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022
937777000666	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
937777000667	Bacterial sugar transferase; Region: Bac_transf; pfam02397
937777000668	Chain length determinant protein; Region: Wzz; pfam02706
937777000669	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
937777000670	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
937777000671	HNH endonuclease; Region: HNH_3; pfam13392
937777000672	Helix-turn-helix domain; Region: HTH_17; pfam12728
937777000673	DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023
937777000674	Helix-turn-helix domain; Region: HTH_36; pfam13730
937777000675	Beta-lactamase; Region: Beta-lactamase; pfam00144
937777000676	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
937777000677	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
937777000678	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
937777000679	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
937777000680	putative active site [active]
937777000681	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
937777000682	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
937777000683	putative active site cavity [active]
937777000684	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
937777000685	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777000686	dimer interface [polypeptide binding]; other site
937777000687	conserved gate region; other site
937777000688	putative PBP binding loops; other site
937777000689	ABC-ATPase subunit interface; other site
937777000690	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
937777000691	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
937777000692	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777000693	putative PBP binding loops; other site
937777000694	dimer interface [polypeptide binding]; other site
937777000695	ABC-ATPase subunit interface; other site
937777000696	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
937777000697	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
937777000698	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
937777000699	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
937777000700	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
937777000701	putative active site [active]
937777000702	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
937777000703	MarR family; Region: MarR_2; pfam12802
937777000704	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
937777000705	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
937777000706	active site
937777000707	nucleophile elbow; other site
937777000708	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
937777000709	Fasciclin domain; Region: Fasciclin; pfam02469
937777000710	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
937777000711	Fasciclin domain; Region: Fasciclin; pfam02469
937777000712	BON domain; Region: BON; pfam04972
937777000713	PRC-barrel domain; Region: PRC; pfam05239
937777000714	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
937777000715	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
937777000716	protein binding site [polypeptide binding]; other site
937777000717	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
937777000718	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
937777000719	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
937777000720	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
937777000721	Transposase; Region: HTH_Tnp_1; cl17663
937777000722	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
937777000723	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
937777000724	mercuric reductase; Validated; Region: PRK06370
937777000725	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
937777000726	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
937777000727	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
937777000728	putative catalytic residues [active]
937777000729	short chain dehydrogenase; Provisional; Region: PRK06181
937777000730	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
937777000731	putative NAD(P) binding site [chemical binding]; other site
937777000732	active site
937777000733	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
937777000734	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
937777000735	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
937777000736	Chromate transporter; Region: Chromate_transp; pfam02417
937777000737	Chromate transporter; Region: Chromate_transp; pfam02417
937777000738	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
937777000739	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
937777000740	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
937777000741	tricarballylate dehydrogenase; Validated; Region: PRK08274
937777000742	L-aspartate oxidase; Provisional; Region: PRK06175
937777000743	Predicted oxidoreductase [General function prediction only]; Region: COG3573
937777000744	Transcriptional regulators [Transcription]; Region: GntR; COG1802
937777000745	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
937777000746	DNA-binding site [nucleotide binding]; DNA binding site
937777000747	FCD domain; Region: FCD; pfam07729
937777000748	Tetratricopeptide repeat; Region: TPR_12; pfam13424
937777000749	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
937777000750	binding surface
937777000751	TPR motif; other site
937777000752	Tetratricopeptide repeat; Region: TPR_12; pfam13424
937777000753	Tetratricopeptide repeat; Region: TPR_12; pfam13424
937777000754	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
937777000755	metal binding site [ion binding]; metal-binding site
937777000756	active site
937777000757	I-site; other site
937777000758	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
937777000759	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
937777000760	active site
937777000761	catalytic residues [active]
937777000762	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777000763	ATP binding site [chemical binding]; other site
937777000764	Mg2+ binding site [ion binding]; other site
937777000765	G-X-G motif; other site
937777000766	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777000767	PAS domain; Region: PAS_9; pfam13426
937777000768	putative active site [active]
937777000769	heme pocket [chemical binding]; other site
937777000770	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
937777000771	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
937777000772	metal binding site [ion binding]; metal-binding site
937777000773	active site
937777000774	I-site; other site
937777000775	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
937777000776	GAF domain; Region: GAF; pfam01590
937777000777	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777000778	PAS domain; Region: PAS_9; pfam13426
937777000779	putative active site [active]
937777000780	heme pocket [chemical binding]; other site
937777000781	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
937777000782	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
937777000783	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
937777000784	metal binding site [ion binding]; metal-binding site
937777000785	active site
937777000786	I-site; other site
937777000787	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
937777000788	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
937777000789	Tetratricopeptide repeat; Region: TPR_12; pfam13424
937777000790	Tetratricopeptide repeat; Region: TPR_12; pfam13424
937777000791	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
937777000792	binding surface
937777000793	TPR motif; other site
937777000794	Tetratricopeptide repeat; Region: TPR_12; pfam13424
937777000795	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
937777000796	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777000797	dimer interface [polypeptide binding]; other site
937777000798	phosphorylation site [posttranslational modification]
937777000799	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777000800	ATP binding site [chemical binding]; other site
937777000801	Mg2+ binding site [ion binding]; other site
937777000802	G-X-G motif; other site
937777000803	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
937777000804	putative substrate translocation pore; other site
937777000805	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777000806	PAS domain; Region: PAS_9; pfam13426
937777000807	putative active site [active]
937777000808	heme pocket [chemical binding]; other site
937777000809	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
937777000810	GAF domain; Region: GAF; pfam01590
937777000811	PAS domain S-box; Region: sensory_box; TIGR00229
937777000812	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777000813	putative active site [active]
937777000814	heme pocket [chemical binding]; other site
937777000815	PAS fold; Region: PAS_4; pfam08448
937777000816	PAS fold; Region: PAS_3; pfam08447
937777000817	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777000818	putative active site [active]
937777000819	heme pocket [chemical binding]; other site
937777000820	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777000821	PAS fold; Region: PAS_3; pfam08447
937777000822	putative active site [active]
937777000823	heme pocket [chemical binding]; other site
937777000824	PAS domain S-box; Region: sensory_box; TIGR00229
937777000825	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777000826	putative active site [active]
937777000827	heme pocket [chemical binding]; other site
937777000828	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777000829	dimer interface [polypeptide binding]; other site
937777000830	phosphorylation site [posttranslational modification]
937777000831	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777000832	ATP binding site [chemical binding]; other site
937777000833	Mg2+ binding site [ion binding]; other site
937777000834	G-X-G motif; other site
937777000835	Protein of unknown function, DUF606; Region: DUF606; pfam04657
937777000836	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
937777000837	homotrimer interaction site [polypeptide binding]; other site
937777000838	putative active site [active]
937777000839	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
937777000840	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
937777000841	tetramer interface [polypeptide binding]; other site
937777000842	pyridoxal 5'-phosphate binding site [chemical binding]; other site
937777000843	catalytic residue [active]
937777000844	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
937777000845	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
937777000846	non-specific DNA binding site [nucleotide binding]; other site
937777000847	salt bridge; other site
937777000848	sequence-specific DNA binding site [nucleotide binding]; other site
937777000849	Transposase, Mutator family; Region: Transposase_mut; pfam00872
937777000850	Integrase core domain; Region: rve_3; cl15866
937777000851	HNH endonuclease; Region: HNH_3; pfam13392
937777000852	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
937777000853	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
937777000854	Beta-Casp domain; Region: Beta-Casp; smart01027
937777000855	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
937777000856	Tetratricopeptide repeat; Region: TPR_12; pfam13424
937777000857	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
937777000858	Tetratricopeptide repeat; Region: TPR_12; pfam13424
937777000859	binding surface
937777000860	TPR motif; other site
937777000861	putative transposase OrfB; Reviewed; Region: PHA02517
937777000862	HTH-like domain; Region: HTH_21; pfam13276
937777000863	Integrase core domain; Region: rve; pfam00665
937777000864	Integrase core domain; Region: rve_3; pfam13683
937777000865	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777000866	PAS domain; Region: PAS_9; pfam13426
937777000867	putative active site [active]
937777000868	heme pocket [chemical binding]; other site
937777000869	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
937777000870	GAF domain; Region: GAF; pfam01590
937777000871	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
937777000872	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777000873	putative active site [active]
937777000874	heme pocket [chemical binding]; other site
937777000875	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777000876	putative active site [active]
937777000877	heme pocket [chemical binding]; other site
937777000878	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
937777000879	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777000880	putative active site [active]
937777000881	heme pocket [chemical binding]; other site
937777000882	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777000883	dimer interface [polypeptide binding]; other site
937777000884	phosphorylation site [posttranslational modification]
937777000885	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777000886	ATP binding site [chemical binding]; other site
937777000887	Mg2+ binding site [ion binding]; other site
937777000888	G-X-G motif; other site
937777000889	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
937777000890	Response regulator receiver domain; Region: Response_reg; pfam00072
937777000891	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777000892	active site
937777000893	phosphorylation site [posttranslational modification]
937777000894	intermolecular recognition site; other site
937777000895	dimerization interface [polypeptide binding]; other site
937777000896	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
937777000897	GAF domain; Region: GAF; pfam01590
937777000898	GAF domain; Region: GAF_3; pfam13492
937777000899	GAF domain; Region: GAF_2; pfam13185
937777000900	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
937777000901	GAF domain; Region: GAF; cl17456
937777000902	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
937777000903	PAS domain; Region: PAS; smart00091
937777000904	putative active site [active]
937777000905	heme pocket [chemical binding]; other site
937777000906	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777000907	dimer interface [polypeptide binding]; other site
937777000908	phosphorylation site [posttranslational modification]
937777000909	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777000910	ATP binding site [chemical binding]; other site
937777000911	Mg2+ binding site [ion binding]; other site
937777000912	G-X-G motif; other site
937777000913	Response regulator receiver domain; Region: Response_reg; pfam00072
937777000914	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777000915	active site
937777000916	phosphorylation site [posttranslational modification]
937777000917	intermolecular recognition site; other site
937777000918	dimerization interface [polypeptide binding]; other site
937777000919	Response regulator receiver domain; Region: Response_reg; pfam00072
937777000920	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777000921	active site
937777000922	phosphorylation site [posttranslational modification]
937777000923	intermolecular recognition site; other site
937777000924	dimerization interface [polypeptide binding]; other site
937777000925	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
937777000926	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
937777000927	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777000928	PAS domain; Region: PAS_9; pfam13426
937777000929	putative active site [active]
937777000930	heme pocket [chemical binding]; other site
937777000931	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777000932	ATP binding site [chemical binding]; other site
937777000933	Mg2+ binding site [ion binding]; other site
937777000934	G-X-G motif; other site
937777000935	Transposase; Region: DEDD_Tnp_IS110; pfam01548
937777000936	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
937777000937	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
937777000938	Transposase; Region: HTH_Tnp_1; pfam01527
937777000939	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
937777000940	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
937777000941	active site
937777000942	DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975
937777000943	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
937777000944	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
937777000945	sugar binding site [chemical binding]; other site
937777000946	HicB family; Region: HicB; pfam05534
937777000947	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
937777000948	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
937777000949	DsrE/DsrF-like family; Region: DrsE; cl00672
937777000950	methionine sulfoxide reductase B; Provisional; Region: PRK00222
937777000951	SelR domain; Region: SelR; pfam01641
937777000952	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
937777000953	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
937777000954	Soluble P-type ATPase [General function prediction only]; Region: COG4087
937777000955	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
937777000956	extended (e) SDRs; Region: SDR_e; cd08946
937777000957	NAD(P) binding site [chemical binding]; other site
937777000958	active site
937777000959	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
937777000960	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
937777000961	active site
937777000962	dimer interface [polypeptide binding]; other site
937777000963	non-prolyl cis peptide bond; other site
937777000964	insertion regions; other site
937777000965	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
937777000966	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
937777000967	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
937777000968	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
937777000969	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
937777000970	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
937777000971	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
937777000972	ABC-ATPase subunit  interface; other site
937777000973	dimer interface [polypeptide binding]; other site
937777000974	putative PBP binding regions; other site
937777000975	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
937777000976	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
937777000977	ABC-ATPase subunit  interface; other site
937777000978	dimer interface [polypeptide binding]; other site
937777000979	putative PBP binding regions; other site
937777000980	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
937777000981	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
937777000982	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
937777000983	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
937777000984	intersubunit interface [polypeptide binding]; other site
937777000985	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
937777000986	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
937777000987	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
937777000988	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
937777000989	putative carbohydrate kinase; Provisional; Region: PRK10565
937777000990	ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133
937777000991	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
937777000992	Walker A/P-loop; other site
937777000993	ATP binding site [chemical binding]; other site
937777000994	Q-loop/lid; other site
937777000995	ABC transporter signature motif; other site
937777000996	Walker B; other site
937777000997	D-loop; other site
937777000998	H-loop/switch region; other site
937777000999	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
937777001000	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
937777001001	classical (c) SDRs; Region: SDR_c; cd05233
937777001002	NAD(P) binding site [chemical binding]; other site
937777001003	active site
937777001004	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
937777001005	Amidase; Region: Amidase; pfam01425
937777001006	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
937777001007	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511
937777001008	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
937777001009	clavulanic acid dehydrogenase (CAD), classical (c) SDR; Region: CAD_SDR_c; cd08934
937777001010	NADP binding site [chemical binding]; other site
937777001011	homotetramer interface [polypeptide binding]; other site
937777001012	homodimer interface [polypeptide binding]; other site
937777001013	active site
937777001014	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
937777001015	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
937777001016	active site
937777001017	Zn binding site [ion binding]; other site
937777001018	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
937777001019	hypothetical protein; Provisional; Region: PRK08201
937777001020	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
937777001021	metal binding site [ion binding]; metal-binding site
937777001022	putative dimer interface [polypeptide binding]; other site
937777001023	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
937777001024	classical (c) SDRs; Region: SDR_c; cd05233
937777001025	NAD(P) binding site [chemical binding]; other site
937777001026	active site
937777001027	Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893
937777001028	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
937777001029	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
937777001030	Creatinine amidohydrolase; Region: Creatininase; pfam02633
937777001031	Predicted transcriptional regulators [Transcription]; Region: COG1725
937777001032	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
937777001033	DNA-binding site [nucleotide binding]; DNA binding site
937777001034	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
937777001035	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
937777001036	Walker A/P-loop; other site
937777001037	ATP binding site [chemical binding]; other site
937777001038	Q-loop/lid; other site
937777001039	ABC transporter signature motif; other site
937777001040	Walker B; other site
937777001041	D-loop; other site
937777001042	H-loop/switch region; other site
937777001043	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
937777001044	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
937777001045	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
937777001046	Walker A/P-loop; other site
937777001047	ATP binding site [chemical binding]; other site
937777001048	Q-loop/lid; other site
937777001049	ABC transporter signature motif; other site
937777001050	Walker B; other site
937777001051	D-loop; other site
937777001052	H-loop/switch region; other site
937777001053	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
937777001054	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
937777001055	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777001056	dimer interface [polypeptide binding]; other site
937777001057	conserved gate region; other site
937777001058	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
937777001059	ABC-ATPase subunit interface; other site
937777001060	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
937777001061	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777001062	dimer interface [polypeptide binding]; other site
937777001063	conserved gate region; other site
937777001064	putative PBP binding loops; other site
937777001065	ABC-ATPase subunit interface; other site
937777001066	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
937777001067	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
937777001068	Predicted deacylase [General function prediction only]; Region: COG3608
937777001069	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
937777001070	active site
937777001071	Zn binding site [ion binding]; other site
937777001072	multidrug resistance protein MdtH; Provisional; Region: PRK11646
937777001073	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
937777001074	putative substrate translocation pore; other site
937777001075	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
937777001076	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
937777001077	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
937777001078	mercuric reductase; Validated; Region: PRK06370
937777001079	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
937777001080	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
937777001081	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
937777001082	Domain of unknown function (DUF427); Region: DUF427; pfam04248
937777001083	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
937777001084	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
937777001085	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
937777001086	oxidoreductase; Provisional; Region: PRK12743
937777001087	NAD(P) binding site [chemical binding]; other site
937777001088	active site
937777001089	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
937777001090	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
937777001091	ligand binding site [chemical binding]; other site
937777001092	flexible hinge region; other site
937777001093	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
937777001094	putative switch regulator; other site
937777001095	non-specific DNA interactions [nucleotide binding]; other site
937777001096	DNA binding site [nucleotide binding]
937777001097	sequence specific DNA binding site [nucleotide binding]; other site
937777001098	putative cAMP binding site [chemical binding]; other site
937777001099	hypothetical protein; Provisional; Region: PRK02237
937777001100	Protein of unknown function (DUF1360); Region: DUF1360; pfam07098
937777001101	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
937777001102	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
937777001103	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
937777001104	Walker A/P-loop; other site
937777001105	ATP binding site [chemical binding]; other site
937777001106	Q-loop/lid; other site
937777001107	ABC transporter signature motif; other site
937777001108	Walker B; other site
937777001109	D-loop; other site
937777001110	H-loop/switch region; other site
937777001111	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
937777001112	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
937777001113	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
937777001114	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
937777001115	Protein of unknown function (DUF1684); Region: DUF1684; pfam07920
937777001116	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
937777001117	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
937777001118	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
937777001119	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
937777001120	catalytic residues [active]
937777001121	Predicted membrane protein [Function unknown]; Region: COG3462
937777001122	Short C-terminal domain; Region: SHOCT; pfam09851
937777001123	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
937777001124	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
937777001125	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
937777001126	metal-binding site [ion binding]
937777001127	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
937777001128	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
937777001129	Soluble P-type ATPase [General function prediction only]; Region: COG4087
937777001130	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
937777001131	DNA binding residues [nucleotide binding]
937777001132	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
937777001133	CopC domain; Region: CopC; pfam04234
937777001134	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
937777001135	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
937777001136	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
937777001137	dimerization interface [polypeptide binding]; other site
937777001138	putative DNA binding site [nucleotide binding]; other site
937777001139	putative Zn2+ binding site [ion binding]; other site
937777001140	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
937777001141	active site residue [active]
937777001142	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
937777001143	Major Facilitator Superfamily; Region: MFS_1; pfam07690
937777001144	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
937777001145	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
937777001146	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
937777001147	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777001148	active site
937777001149	phosphorylation site [posttranslational modification]
937777001150	intermolecular recognition site; other site
937777001151	dimerization interface [polypeptide binding]; other site
937777001152	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
937777001153	DNA binding site [nucleotide binding]
937777001154	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
937777001155	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
937777001156	dimerization interface [polypeptide binding]; other site
937777001157	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777001158	phosphorylation site [posttranslational modification]
937777001159	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777001160	ATP binding site [chemical binding]; other site
937777001161	Mg2+ binding site [ion binding]; other site
937777001162	G-X-G motif; other site
937777001163	Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; cl01558
937777001164	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
937777001165	BNR repeat-like domain; Region: BNR_2; pfam13088
937777001166	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
937777001167	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
937777001168	Protein of unknown function (DUF1440); Region: DUF1440; cl01380
937777001169	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
937777001170	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
937777001171	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
937777001172	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
937777001173	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
937777001174	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
937777001175	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
937777001176	DNA binding site [nucleotide binding]
937777001177	Transcriptional regulators [Transcription]; Region: PurR; COG1609
937777001178	domain linker motif; other site
937777001179	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
937777001180	ligand binding site [chemical binding]; other site
937777001181	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
937777001182	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
937777001183	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
937777001184	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777001185	dimer interface [polypeptide binding]; other site
937777001186	conserved gate region; other site
937777001187	putative PBP binding loops; other site
937777001188	ABC-ATPase subunit interface; other site
937777001189	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
937777001190	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777001191	dimer interface [polypeptide binding]; other site
937777001192	conserved gate region; other site
937777001193	putative PBP binding loops; other site
937777001194	ABC-ATPase subunit interface; other site
937777001195	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
937777001196	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
937777001197	Walker A/P-loop; other site
937777001198	ATP binding site [chemical binding]; other site
937777001199	Q-loop/lid; other site
937777001200	ABC transporter signature motif; other site
937777001201	Walker B; other site
937777001202	D-loop; other site
937777001203	H-loop/switch region; other site
937777001204	TOBE domain; Region: TOBE_2; pfam08402
937777001205	Trehalase; Region: Trehalase; cl17346
937777001206	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
937777001207	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
937777001208	MOFRL family; Region: MOFRL; pfam05161
937777001209	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
937777001210	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
937777001211	nucleotide binding site [chemical binding]; other site
937777001212	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
937777001213	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
937777001214	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
937777001215	Soluble P-type ATPase [General function prediction only]; Region: COG4087
937777001216	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
937777001217	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
937777001218	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
937777001219	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
937777001220	PAS fold; Region: PAS_4; pfam08448
937777001221	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777001222	putative active site [active]
937777001223	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
937777001224	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
937777001225	metal binding site [ion binding]; metal-binding site
937777001226	active site
937777001227	I-site; other site
937777001228	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
937777001229	RibD C-terminal domain; Region: RibD_C; cl17279
937777001230	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
937777001231	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
937777001232	Phosphotransferase enzyme family; Region: APH; pfam01636
937777001233	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
937777001234	active site
937777001235	ATP binding site [chemical binding]; other site
937777001236	substrate binding site [chemical binding]; other site
937777001237	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
937777001238	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
937777001239	Coenzyme A binding pocket [chemical binding]; other site
937777001240	PAS fold; Region: PAS_4; pfam08448
937777001241	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777001242	putative active site [active]
937777001243	heme pocket [chemical binding]; other site
937777001244	GAF domain; Region: GAF; pfam01590
937777001245	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
937777001246	GAF domain; Region: GAF; pfam01590
937777001247	GAF domain; Region: GAF; pfam01590
937777001248	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777001249	dimer interface [polypeptide binding]; other site
937777001250	phosphorylation site [posttranslational modification]
937777001251	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777001252	ATP binding site [chemical binding]; other site
937777001253	Mg2+ binding site [ion binding]; other site
937777001254	G-X-G motif; other site
937777001255	Response regulator receiver domain; Region: Response_reg; pfam00072
937777001256	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777001257	active site
937777001258	phosphorylation site [posttranslational modification]
937777001259	intermolecular recognition site; other site
937777001260	dimerization interface [polypeptide binding]; other site
937777001261	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777001262	PAS domain; Region: PAS_9; pfam13426
937777001263	putative active site [active]
937777001264	heme pocket [chemical binding]; other site
937777001265	PAS fold; Region: PAS_4; pfam08448
937777001266	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
937777001267	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
937777001268	GAF domain; Region: GAF_3; pfam13492
937777001269	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777001270	dimer interface [polypeptide binding]; other site
937777001271	phosphorylation site [posttranslational modification]
937777001272	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777001273	ATP binding site [chemical binding]; other site
937777001274	Mg2+ binding site [ion binding]; other site
937777001275	G-X-G motif; other site
937777001276	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
937777001277	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
937777001278	catalytic residues [active]
937777001279	catalytic nucleophile [active]
937777001280	Presynaptic Site I dimer interface [polypeptide binding]; other site
937777001281	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
937777001282	Synaptic Flat tetramer interface [polypeptide binding]; other site
937777001283	Synaptic Site I dimer interface [polypeptide binding]; other site
937777001284	DNA binding site [nucleotide binding]
937777001285	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
937777001286	DNA-binding interface [nucleotide binding]; DNA binding site
937777001287	putative transposase OrfB; Reviewed; Region: PHA02517
937777001288	HTH-like domain; Region: HTH_21; pfam13276
937777001289	Integrase core domain; Region: rve; pfam00665
937777001290	Integrase core domain; Region: rve_3; pfam13683
937777001291	Transposase; Region: HTH_Tnp_1; pfam01527
937777001292	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
937777001293	Fic family protein [Function unknown]; Region: COG3177
937777001294	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
937777001295	Fic/DOC family; Region: Fic; pfam02661
937777001296	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
937777001297	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
937777001298	catalytic residues [active]
937777001299	catalytic nucleophile [active]
937777001300	Recombinase; Region: Recombinase; pfam07508
937777001301	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
937777001302	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
937777001303	putative active site [active]
937777001304	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
937777001305	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
937777001306	P-loop; other site
937777001307	Magnesium ion binding site [ion binding]; other site
937777001308	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
937777001309	tRNA binding surface [nucleotide binding]; other site
937777001310	anticodon binding site; other site
937777001311	ParB-like nuclease domain; Region: ParB; smart00470
937777001312	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
937777001313	nucleotide binding site [chemical binding]; other site
937777001314	polymerase nucleotide-binding site; other site
937777001315	primase nucleotide-binding site [nucleotide binding]; other site
937777001316	DNA-binding residues [nucleotide binding]; DNA binding site
937777001317	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
937777001318	HSP70 interaction site [polypeptide binding]; other site
937777001319	SEFIR domain; Region: SEFIR; pfam08357
937777001320	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
937777001321	HD domain; Region: HD_3; pfam13023
937777001322	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
937777001323	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
937777001324	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777001325	active site
937777001326	phosphorylation site [posttranslational modification]
937777001327	intermolecular recognition site; other site
937777001328	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
937777001329	DNA binding residues [nucleotide binding]
937777001330	dimerization interface [polypeptide binding]; other site
937777001331	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
937777001332	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777001333	ATP binding site [chemical binding]; other site
937777001334	Mg2+ binding site [ion binding]; other site
937777001335	G-X-G motif; other site
937777001336	Transposase; Region: DEDD_Tnp_IS110; pfam01548
937777001337	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
937777001338	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
937777001339	VbhA antitoxin and related proteins; Region: VbhA_like; cd11586
937777001340	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
937777001341	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
937777001342	active site
937777001343	catalytic triad [active]
937777001344	short chain dehydrogenase; Provisional; Region: PRK07326
937777001345	classical (c) SDR, subgroup 4; Region: SDR_c4; cd08929
937777001346	putative NAD(P) binding site [chemical binding]; other site
937777001347	homodimer interface [polypeptide binding]; other site
937777001348	active site
937777001349	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333
937777001350	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
937777001351	homodimer interface [polypeptide binding]; other site
937777001352	metal binding site [ion binding]; metal-binding site
937777001353	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
937777001354	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
937777001355	putative active site [active]
937777001356	putative CoA binding site [chemical binding]; other site
937777001357	nudix motif; other site
937777001358	metal binding site [ion binding]; metal-binding site
937777001359	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
937777001360	Clp amino terminal domain; Region: Clp_N; pfam02861
937777001361	Clp amino terminal domain; Region: Clp_N; pfam02861
937777001362	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
937777001363	Walker A motif; other site
937777001364	ATP binding site [chemical binding]; other site
937777001365	Walker B motif; other site
937777001366	arginine finger; other site
937777001367	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
937777001368	Walker A motif; other site
937777001369	ATP binding site [chemical binding]; other site
937777001370	Walker B motif; other site
937777001371	arginine finger; other site
937777001372	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
937777001373	DNA repair protein RadA; Provisional; Region: PRK11823
937777001374	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
937777001375	Walker A motif; other site
937777001376	ATP binding site [chemical binding]; other site
937777001377	Walker B motif; other site
937777001378	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
937777001379	putative active site [active]
937777001380	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
937777001381	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607
937777001382	active site
937777001383	Zn binding site [ion binding]; other site
937777001384	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
937777001385	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
937777001386	substrate binding site [chemical binding]; other site
937777001387	ligand binding site [chemical binding]; other site
937777001388	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
937777001389	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
937777001390	substrate binding site [chemical binding]; other site
937777001391	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
937777001392	tartrate dehydrogenase; Region: TTC; TIGR02089
937777001393	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
937777001394	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
937777001395	PYR/PP interface [polypeptide binding]; other site
937777001396	dimer interface [polypeptide binding]; other site
937777001397	TPP binding site [chemical binding]; other site
937777001398	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
937777001399	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
937777001400	TPP-binding site [chemical binding]; other site
937777001401	dimer interface [polypeptide binding]; other site
937777001402	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
937777001403	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
937777001404	putative valine binding site [chemical binding]; other site
937777001405	dimer interface [polypeptide binding]; other site
937777001406	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
937777001407	ketol-acid reductoisomerase; Provisional; Region: PRK05479
937777001408	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
937777001409	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
937777001410	2-isopropylmalate synthase; Validated; Region: PRK00915
937777001411	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
937777001412	active site
937777001413	catalytic residues [active]
937777001414	metal binding site [ion binding]; metal-binding site
937777001415	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
937777001416	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
937777001417	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
937777001418	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
937777001419	active site
937777001420	metal binding site [ion binding]; metal-binding site
937777001421	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
937777001422	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
937777001423	active site
937777001424	homodimer interface [polypeptide binding]; other site
937777001425	catalytic site [active]
937777001426	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
937777001427	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
937777001428	metal binding triad [ion binding]; metal-binding site
937777001429	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
937777001430	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
937777001431	Zn2+ binding site [ion binding]; other site
937777001432	Mg2+ binding site [ion binding]; other site
937777001433	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
937777001434	active site
937777001435	beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555
937777001436	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
937777001437	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
937777001438	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
937777001439	putative substrate binding site [chemical binding]; other site
937777001440	putative ATP binding site [chemical binding]; other site
937777001441	Protein of unknown function, DUF608; Region: DUF608; pfam04685
937777001442	Alkaline and neutral invertase; Region: Glyco_hydro_100; cl17340
937777001443	beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555
937777001444	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
937777001445	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
937777001446	C-terminal domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_C; cd10317
937777001447	Ca binding site [ion binding]; other site
937777001448	substrate binding site [chemical binding]; other site
937777001449	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
937777001450	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
937777001451	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
937777001452	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
937777001453	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
937777001454	intersubunit interface [polypeptide binding]; other site
937777001455	active site
937777001456	zinc binding site [ion binding]; other site
937777001457	Na+ binding site [ion binding]; other site
937777001458	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177
937777001459	alpha-mannosidase; Provisional; Region: PRK09819
937777001460	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
937777001461	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
937777001462	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
937777001463	catalytic site [active]
937777001464	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
937777001465	active site
937777001466	catalytic site [active]
937777001467	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
937777001468	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
937777001469	Methane oxygenase PmoA; Region: PmoA; pfam14100
937777001470	alpha-galactosidase; Provisional; Region: PRK15076
937777001471	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
937777001472	NAD(P) binding site [chemical binding]; other site
937777001473	LDH/MDH dimer interface [polypeptide binding]; other site
937777001474	substrate binding site [chemical binding]; other site
937777001475	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
937777001476	ROK family; Region: ROK; pfam00480
937777001477	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
937777001478	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777001479	dimer interface [polypeptide binding]; other site
937777001480	conserved gate region; other site
937777001481	putative PBP binding loops; other site
937777001482	ABC-ATPase subunit interface; other site
937777001483	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777001484	dimer interface [polypeptide binding]; other site
937777001485	conserved gate region; other site
937777001486	putative PBP binding loops; other site
937777001487	ABC-ATPase subunit interface; other site
937777001488	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
937777001489	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
937777001490	nucleotide binding site [chemical binding]; other site
937777001491	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
937777001492	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
937777001493	dimer interface [polypeptide binding]; other site
937777001494	active site
937777001495	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
937777001496	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
937777001497	active site
937777001498	catalytic site [active]
937777001499	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
937777001500	Major Facilitator Superfamily; Region: MFS_1; pfam07690
937777001501	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
937777001502	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
937777001503	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
937777001504	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
937777001505	Sulfatase; Region: Sulfatase; cl17466
937777001506	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
937777001507	Sulfatase; Region: Sulfatase; cl17466
937777001508	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
937777001509	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
937777001510	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
937777001511	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
937777001512	active site
937777001513	dimer interface [polypeptide binding]; other site
937777001514	Sulfatase; Region: Sulfatase; cl17466
937777001515	choline-sulfatase; Region: chol_sulfatase; TIGR03417
937777001516	Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411
937777001517	Response regulator receiver domain; Region: Response_reg; pfam00072
937777001518	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777001519	active site
937777001520	phosphorylation site [posttranslational modification]
937777001521	intermolecular recognition site; other site
937777001522	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
937777001523	GAF domain; Region: GAF; pfam01590
937777001524	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
937777001525	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
937777001526	metal binding site [ion binding]; metal-binding site
937777001527	active site
937777001528	I-site; other site
937777001529	Response regulator receiver domain; Region: Response_reg; pfam00072
937777001530	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777001531	active site
937777001532	phosphorylation site [posttranslational modification]
937777001533	intermolecular recognition site; other site
937777001534	dimerization interface [polypeptide binding]; other site
937777001535	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777001536	PAS domain; Region: PAS_9; pfam13426
937777001537	putative active site [active]
937777001538	heme pocket [chemical binding]; other site
937777001539	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777001540	PAS fold; Region: PAS_3; pfam08447
937777001541	putative active site [active]
937777001542	heme pocket [chemical binding]; other site
937777001543	PAS domain; Region: PAS_9; pfam13426
937777001544	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
937777001545	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
937777001546	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777001547	dimer interface [polypeptide binding]; other site
937777001548	phosphorylation site [posttranslational modification]
937777001549	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777001550	ATP binding site [chemical binding]; other site
937777001551	Mg2+ binding site [ion binding]; other site
937777001552	G-X-G motif; other site
937777001553	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
937777001554	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
937777001555	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
937777001556	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
937777001557	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
937777001558	active site
937777001559	catalytic site [active]
937777001560	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
937777001561	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
937777001562	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
937777001563	putative aldolase; Validated; Region: PRK08130
937777001564	intersubunit interface [polypeptide binding]; other site
937777001565	active site
937777001566	Zn2+ binding site [ion binding]; other site
937777001567	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354
937777001568	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
937777001569	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777001570	active site
937777001571	phosphorylation site [posttranslational modification]
937777001572	intermolecular recognition site; other site
937777001573	dimerization interface [polypeptide binding]; other site
937777001574	Response regulator receiver domain; Region: Response_reg; pfam00072
937777001575	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777001576	active site
937777001577	phosphorylation site [posttranslational modification]
937777001578	intermolecular recognition site; other site
937777001579	dimerization interface [polypeptide binding]; other site
937777001580	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
937777001581	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
937777001582	active site
937777001583	dimer interface [polypeptide binding]; other site
937777001584	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
937777001585	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
937777001586	active site
937777001587	FMN binding site [chemical binding]; other site
937777001588	substrate binding site [chemical binding]; other site
937777001589	3Fe-4S cluster binding site [ion binding]; other site
937777001590	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
937777001591	domain interface; other site
937777001592	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
937777001593	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
937777001594	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
937777001595	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
937777001596	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
937777001597	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
937777001598	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
937777001599	Walker A motif; other site
937777001600	ATP binding site [chemical binding]; other site
937777001601	Walker B motif; other site
937777001602	Predicted transcriptional regulators [Transcription]; Region: COG1695
937777001603	Transcriptional regulator PadR-like family; Region: PadR; cl17335
937777001604	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
937777001605	active site
937777001606	homotetramer interface [polypeptide binding]; other site
937777001607	urate oxidase; Region: urate_oxi; TIGR03383
937777001608	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
937777001609	active site
937777001610	OHCU decarboxylase; Region: OHCU_decarbox; cl01251
937777001611	Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630
937777001612	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
937777001613	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
937777001614	Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631
937777001615	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
937777001616	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
937777001617	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
937777001618	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
937777001619	XdhC Rossmann domain; Region: XdhC_C; pfam13478
937777001620	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
937777001621	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
937777001622	Walker A/P-loop; other site
937777001623	ATP binding site [chemical binding]; other site
937777001624	Q-loop/lid; other site
937777001625	ABC transporter signature motif; other site
937777001626	Walker B; other site
937777001627	D-loop; other site
937777001628	H-loop/switch region; other site
937777001629	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
937777001630	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
937777001631	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
937777001632	TM-ABC transporter signature motif; other site
937777001633	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
937777001634	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
937777001635	TM-ABC transporter signature motif; other site
937777001636	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
937777001637	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
937777001638	putative ligand binding site [chemical binding]; other site
937777001639	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
937777001640	Transcriptional regulators [Transcription]; Region: PurR; COG1609
937777001641	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
937777001642	DNA binding site [nucleotide binding]
937777001643	domain linker motif; other site
937777001644	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
937777001645	dimerization interface [polypeptide binding]; other site
937777001646	ligand binding site [chemical binding]; other site
937777001647	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
937777001648	The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509
937777001649	substrate binding site [chemical binding]; other site
937777001650	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
937777001651	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777001652	putative PBP binding loops; other site
937777001653	dimer interface [polypeptide binding]; other site
937777001654	ABC-ATPase subunit interface; other site
937777001655	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
937777001656	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777001657	dimer interface [polypeptide binding]; other site
937777001658	conserved gate region; other site
937777001659	putative PBP binding loops; other site
937777001660	ABC-ATPase subunit interface; other site
937777001661	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
937777001662	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
937777001663	Walker A/P-loop; other site
937777001664	ATP binding site [chemical binding]; other site
937777001665	Q-loop/lid; other site
937777001666	ABC transporter signature motif; other site
937777001667	Walker B; other site
937777001668	D-loop; other site
937777001669	H-loop/switch region; other site
937777001670	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
937777001671	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
937777001672	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
937777001673	Walker A/P-loop; other site
937777001674	ATP binding site [chemical binding]; other site
937777001675	Q-loop/lid; other site
937777001676	ABC transporter signature motif; other site
937777001677	Walker B; other site
937777001678	D-loop; other site
937777001679	H-loop/switch region; other site
937777001680	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
937777001681	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
937777001682	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
937777001683	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
937777001684	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
937777001685	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
937777001686	active site
937777001687	HIGH motif; other site
937777001688	KMSKS motif; other site
937777001689	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
937777001690	tRNA binding surface [nucleotide binding]; other site
937777001691	anticodon binding site; other site
937777001692	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
937777001693	dimer interface [polypeptide binding]; other site
937777001694	putative tRNA-binding site [nucleotide binding]; other site
937777001695	Major Facilitator Superfamily; Region: MFS_1; pfam07690
937777001696	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
937777001697	putative substrate translocation pore; other site
937777001698	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
937777001699	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
937777001700	MarR family; Region: MarR_2; pfam12802
937777001701	isocitrate dehydrogenase; Validated; Region: PRK07362
937777001702	isocitrate dehydrogenase; Reviewed; Region: PRK07006
937777001703	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
937777001704	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
937777001705	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
937777001706	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
937777001707	B12 binding site [chemical binding]; other site
937777001708	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
937777001709	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
937777001710	FeS/SAM binding site; other site
937777001711	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
937777001712	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
937777001713	putative substrate translocation pore; other site
937777001714	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
937777001715	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
937777001716	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
937777001717	catalytic loop [active]
937777001718	iron binding site [ion binding]; other site
937777001719	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
937777001720	4Fe-4S binding domain; Region: Fer4_6; pfam12837
937777001721	4Fe-4S binding domain; Region: Fer4; pfam00037
937777001722	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
937777001723	[4Fe-4S] binding site [ion binding]; other site
937777001724	molybdopterin cofactor binding site; other site
937777001725	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
937777001726	molybdopterin cofactor binding site; other site
937777001727	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
937777001728	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
937777001729	Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281
937777001730	NAD binding site [chemical binding]; other site
937777001731	catalytic Zn binding site [ion binding]; other site
937777001732	substrate binding site [chemical binding]; other site
937777001733	structural Zn binding site [ion binding]; other site
937777001734	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
937777001735	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
937777001736	catalytic residues [active]
937777001737	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
937777001738	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
937777001739	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
937777001740	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
937777001741	Walker A/P-loop; other site
937777001742	ATP binding site [chemical binding]; other site
937777001743	Q-loop/lid; other site
937777001744	ABC transporter signature motif; other site
937777001745	Walker B; other site
937777001746	D-loop; other site
937777001747	H-loop/switch region; other site
937777001748	DivIVA protein; Region: DivIVA; pfam05103
937777001749	DivIVA domain; Region: DivI1A_domain; TIGR03544
937777001750	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
937777001751	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
937777001752	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
937777001753	catalytic residue [active]
937777001754	purine nucleoside phosphorylase; Provisional; Region: PRK08202
937777001755	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
937777001756	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
937777001757	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
937777001758	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
937777001759	Surface antigen; Region: Bac_surface_Ag; pfam01103
937777001760	Protein of unknown function (DUF3084); Region: DUF3084; pfam11283
937777001761	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
937777001762	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
937777001763	Walker A/P-loop; other site
937777001764	ATP binding site [chemical binding]; other site
937777001765	Q-loop/lid; other site
937777001766	ABC transporter signature motif; other site
937777001767	Walker B; other site
937777001768	D-loop; other site
937777001769	H-loop/switch region; other site
937777001770	phosphopentomutase; Provisional; Region: PRK05362
937777001771	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
937777001772	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
937777001773	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
937777001774	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
937777001775	histidinol dehydrogenase; Region: hisD; TIGR00069
937777001776	NAD binding site [chemical binding]; other site
937777001777	dimerization interface [polypeptide binding]; other site
937777001778	product binding site; other site
937777001779	substrate binding site [chemical binding]; other site
937777001780	zinc binding site [ion binding]; other site
937777001781	catalytic residues [active]
937777001782	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
937777001783	catalytic core [active]
937777001784	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
937777001785	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
937777001786	active site
937777001787	metal binding site [ion binding]; metal-binding site
937777001788	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
937777001789	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
937777001790	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
937777001791	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
937777001792	active site
937777001793	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
937777001794	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
937777001795	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
937777001796	putative NADH binding site [chemical binding]; other site
937777001797	putative active site [active]
937777001798	nudix motif; other site
937777001799	putative metal binding site [ion binding]; other site
937777001800	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
937777001801	SurA N-terminal domain; Region: SurA_N_3; cl07813
937777001802	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
937777001803	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
937777001804	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
937777001805	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
937777001806	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
937777001807	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
937777001808	intersubunit interface [polypeptide binding]; other site
937777001809	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
937777001810	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
937777001811	heme-binding site [chemical binding]; other site
937777001812	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
937777001813	tandem repeat interface [polypeptide binding]; other site
937777001814	oligomer interface [polypeptide binding]; other site
937777001815	active site residues [active]
937777001816	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
937777001817	tandem repeat interface [polypeptide binding]; other site
937777001818	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
937777001819	oligomer interface [polypeptide binding]; other site
937777001820	active site residues [active]
937777001821	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
937777001822	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
937777001823	Zn binding site [ion binding]; other site
937777001824	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
937777001825	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
937777001826	Zn binding site [ion binding]; other site
937777001827	Predicted esterase [General function prediction only]; Region: COG0400
937777001828	putative hydrolase; Provisional; Region: PRK11460
937777001829	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
937777001830	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
937777001831	HIGH motif; other site
937777001832	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
937777001833	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
937777001834	active site
937777001835	KMSKS motif; other site
937777001836	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
937777001837	tRNA binding surface [nucleotide binding]; other site
937777001838	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
937777001839	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
937777001840	non-specific DNA binding site [nucleotide binding]; other site
937777001841	salt bridge; other site
937777001842	sequence-specific DNA binding site [nucleotide binding]; other site
937777001843	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
937777001844	active site
937777001845	catalytic residues [active]
937777001846	Tetratricopeptide repeat; Region: TPR_12; pfam13424
937777001847	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
937777001848	binding surface
937777001849	TPR motif; other site
937777001850	Tetratricopeptide repeat; Region: TPR_12; pfam13424
937777001851	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
937777001852	Zn2+ binding site [ion binding]; other site
937777001853	Mg2+ binding site [ion binding]; other site
937777001854	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
937777001855	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
937777001856	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
937777001857	hypothetical protein; Provisional; Region: PRK11171
937777001858	Cupin; Region: Cupin_6; pfam12852
937777001859	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
937777001860	allantoinase; Provisional; Region: PRK06189
937777001861	L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315
937777001862	active site
937777001863	allantoate amidohydrolase; Reviewed; Region: PRK09290
937777001864	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
937777001865	active site
937777001866	metal binding site [ion binding]; metal-binding site
937777001867	dimer interface [polypeptide binding]; other site
937777001868	Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl17217
937777001869	malate synthase A; Region: malate_syn_A; TIGR01344
937777001870	active site
937777001871	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
937777001872	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
937777001873	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
937777001874	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
937777001875	malate synthase A; Region: malate_syn_A; TIGR01344
937777001876	active site
937777001877	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
937777001878	active site
937777001879	catalytic residues [active]
937777001880	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
937777001881	classical (c) SDRs; Region: SDR_c; cd05233
937777001882	NAD(P) binding site [chemical binding]; other site
937777001883	active site
937777001884	AAA domain; Region: AAA_18; pfam13238
937777001885	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
937777001886	active site
937777001887	Uncharacterized conserved protein [Function unknown]; Region: COG4850
937777001888	Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949
937777001889	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
937777001890	putative catalytic site [active]
937777001891	putative metal binding site [ion binding]; other site
937777001892	putative phosphate binding site [ion binding]; other site
937777001893	ribonuclease R; Region: RNase_R; TIGR02063
937777001894	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
937777001895	RNB domain; Region: RNB; pfam00773
937777001896	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
937777001897	RNA binding site [nucleotide binding]; other site
937777001898	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
937777001899	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
937777001900	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
937777001901	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
937777001902	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
937777001903	carboxyltransferase (CT) interaction site; other site
937777001904	biotinylation site [posttranslational modification]; other site
937777001905	elongation factor P; Validated; Region: PRK00529
937777001906	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
937777001907	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
937777001908	RNA binding site [nucleotide binding]; other site
937777001909	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
937777001910	RNA binding site [nucleotide binding]; other site
937777001911	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
937777001912	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
937777001913	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
937777001914	NAD(P) binding site [chemical binding]; other site
937777001915	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
937777001916	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
937777001917	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
937777001918	NAD(P) binding site [chemical binding]; other site
937777001919	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
937777001920	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
937777001921	substrate binding pocket [chemical binding]; other site
937777001922	chain length determination region; other site
937777001923	substrate-Mg2+ binding site; other site
937777001924	catalytic residues [active]
937777001925	aspartate-rich region 1; other site
937777001926	active site lid residues [active]
937777001927	aspartate-rich region 2; other site
937777001928	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
937777001929	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
937777001930	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
937777001931	peptide chain release factor 1; Validated; Region: prfA; PRK00591
937777001932	PCRF domain; Region: PCRF; pfam03462
937777001933	RF-1 domain; Region: RF-1; pfam00472
937777001934	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
937777001935	nudix motif; other site
937777001936	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
937777001937	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
937777001938	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
937777001939	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
937777001940	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
937777001941	RNA binding site [nucleotide binding]; other site
937777001942	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
937777001943	RNA binding site [nucleotide binding]; other site
937777001944	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
937777001945	RNA binding site [nucleotide binding]; other site
937777001946	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
937777001947	RNA binding site [nucleotide binding]; other site
937777001948	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
937777001949	RNA binding site [nucleotide binding]; other site
937777001950	Predicted membrane protein [Function unknown]; Region: COG4270
937777001951	putative acyltransferase; Provisional; Region: PRK05790
937777001952	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
937777001953	dimer interface [polypeptide binding]; other site
937777001954	active site
937777001955	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
937777001956	aromatic arch; other site
937777001957	DCoH dimer interaction site [polypeptide binding]; other site
937777001958	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
937777001959	DCoH tetramer interaction site [polypeptide binding]; other site
937777001960	substrate binding site [chemical binding]; other site
937777001961	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
937777001962	active site
937777001963	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
937777001964	kynureninase; Region: kynureninase; TIGR01814
937777001965	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
937777001966	catalytic residue [active]
937777001967	Putative cyclase; Region: Cyclase; cl00814
937777001968	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
937777001969	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
937777001970	metal binding site [ion binding]; metal-binding site
937777001971	active site
937777001972	I-site; other site
937777001973	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
937777001974	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
937777001975	putative DNA binding site [nucleotide binding]; other site
937777001976	putative Zn2+ binding site [ion binding]; other site
937777001977	AsnC family; Region: AsnC_trans_reg; pfam01037
937777001978	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
937777001979	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
937777001980	hexamer interface [polypeptide binding]; other site
937777001981	ligand binding site [chemical binding]; other site
937777001982	putative active site [active]
937777001983	NAD(P) binding site [chemical binding]; other site
937777001984	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
937777001985	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
937777001986	DAK2 domain; Region: Dak2; pfam02734
937777001987	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
937777001988	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
937777001989	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
937777001990	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
937777001991	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK14655
937777001992	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
937777001993	Mg++ binding site [ion binding]; other site
937777001994	putative catalytic motif [active]
937777001995	putative substrate binding site [chemical binding]; other site
937777001996	UDP-N-acetylmuramoylalanine--D-glutamate ligase; Region: murD; TIGR01087
937777001997	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
937777001998	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
937777001999	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
937777002000	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
937777002001	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
937777002002	active site
937777002003	homodimer interface [polypeptide binding]; other site
937777002004	UDP-N-acetylmuramate--alanine ligase; Region: murC; TIGR01082
937777002005	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
937777002006	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
937777002007	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
937777002008	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14651
937777002009	FAD binding domain; Region: FAD_binding_4; pfam01565
937777002010	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
937777002011	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
937777002012	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
937777002013	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
937777002014	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
937777002015	nucleotide binding site [chemical binding]; other site
937777002016	SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491
937777002017	Cell division protein FtsA; Region: FtsA; pfam14450
937777002018	cell division protein FtsZ; Validated; Region: PRK09330
937777002019	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
937777002020	nucleotide binding site [chemical binding]; other site
937777002021	SulA interaction site; other site
937777002022	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
937777002023	dimer interface [polypeptide binding]; other site
937777002024	ADP-ribose binding site [chemical binding]; other site
937777002025	active site
937777002026	nudix motif; other site
937777002027	metal binding site [ion binding]; metal-binding site
937777002028	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
937777002029	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
937777002030	active site
937777002031	Riboflavin kinase; Region: Flavokinase; smart00904
937777002032	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
937777002033	dimer interface [polypeptide binding]; other site
937777002034	substrate binding site [chemical binding]; other site
937777002035	ATP binding site [chemical binding]; other site
937777002036	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
937777002037	ThiS interaction site; other site
937777002038	putative active site [active]
937777002039	tetramer interface [polypeptide binding]; other site
937777002040	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
937777002041	thiS-thiF/thiG interaction site; other site
937777002042	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
937777002043	thiamine phosphate binding site [chemical binding]; other site
937777002044	active site
937777002045	pyrophosphate binding site [ion binding]; other site
937777002046	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
937777002047	ThiC-associated domain; Region: ThiC-associated; pfam13667
937777002048	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
937777002049	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
937777002050	30S subunit binding site; other site
937777002051	GMP synthase; Reviewed; Region: guaA; PRK00074
937777002052	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
937777002053	AMP/PPi binding site [chemical binding]; other site
937777002054	candidate oxyanion hole; other site
937777002055	catalytic triad [active]
937777002056	potential glutamine specificity residues [chemical binding]; other site
937777002057	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
937777002058	ATP Binding subdomain [chemical binding]; other site
937777002059	Ligand Binding sites [chemical binding]; other site
937777002060	Dimerization subdomain; other site
937777002061	antiporter inner membrane protein; Provisional; Region: PRK11670
937777002062	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
937777002063	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
937777002064	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
937777002065	Predicted transcriptional regulator [Transcription]; Region: COG2345
937777002066	dimerization interface [polypeptide binding]; other site
937777002067	putative DNA binding site [nucleotide binding]; other site
937777002068	putative Zn2+ binding site [ion binding]; other site
937777002069	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
937777002070	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
937777002071	apolar tunnel; other site
937777002072	heme binding site [chemical binding]; other site
937777002073	dimerization interface [polypeptide binding]; other site
937777002074	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
937777002075	RNA/DNA hybrid binding site [nucleotide binding]; other site
937777002076	active site
937777002077	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
937777002078	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
937777002079	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
937777002080	S-adenosylmethionine binding site [chemical binding]; other site
937777002081	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
937777002082	nudix motif; other site
937777002083	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
937777002084	MoxR-like ATPases [General function prediction only]; Region: COG0714
937777002085	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
937777002086	Walker A motif; other site
937777002087	ATP binding site [chemical binding]; other site
937777002088	Walker B motif; other site
937777002089	arginine finger; other site
937777002090	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
937777002091	Protein of unknown function DUF58; Region: DUF58; pfam01882
937777002092	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
937777002093	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
937777002094	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
937777002095	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
937777002096	formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK14811
937777002097	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
937777002098	DNA binding site [nucleotide binding]
937777002099	catalytic residue [active]
937777002100	H2TH interface [polypeptide binding]; other site
937777002101	putative catalytic residues [active]
937777002102	turnover-facilitating residue; other site
937777002103	intercalation triad [nucleotide binding]; other site
937777002104	8OG recognition residue [nucleotide binding]; other site
937777002105	putative reading head residues; other site
937777002106	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
937777002107	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
937777002108	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
937777002109	putative substrate binding pocket [chemical binding]; other site
937777002110	AC domain interface; other site
937777002111	catalytic triad [active]
937777002112	AB domain interface; other site
937777002113	interchain disulfide; other site
937777002114	DinB superfamily; Region: DinB_2; pfam12867
937777002115	HemN C-terminal domain; Region: HemN_C; pfam06969
937777002116	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
937777002117	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
937777002118	putative NAD(P) binding site [chemical binding]; other site
937777002119	putative active site [active]
937777002120	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
937777002121	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777002122	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
937777002123	active site
937777002124	phosphorylation site [posttranslational modification]
937777002125	intermolecular recognition site; other site
937777002126	dimerization interface [polypeptide binding]; other site
937777002127	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
937777002128	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777002129	dimer interface [polypeptide binding]; other site
937777002130	phosphorylation site [posttranslational modification]
937777002131	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777002132	ATP binding site [chemical binding]; other site
937777002133	Mg2+ binding site [ion binding]; other site
937777002134	G-X-G motif; other site
937777002135	CHASE domain; Region: CHASE; pfam03924
937777002136	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
937777002137	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777002138	putative active site [active]
937777002139	heme pocket [chemical binding]; other site
937777002140	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777002141	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
937777002142	putative active site [active]
937777002143	heme pocket [chemical binding]; other site
937777002144	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777002145	putative active site [active]
937777002146	heme pocket [chemical binding]; other site
937777002147	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
937777002148	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777002149	dimer interface [polypeptide binding]; other site
937777002150	phosphorylation site [posttranslational modification]
937777002151	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777002152	ATP binding site [chemical binding]; other site
937777002153	Mg2+ binding site [ion binding]; other site
937777002154	G-X-G motif; other site
937777002155	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
937777002156	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
937777002157	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
937777002158	NAD(P) binding site [chemical binding]; other site
937777002159	shikimate binding site; other site
937777002160	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
937777002161	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245
937777002162	PhoH-like protein; Region: PhoH; pfam02562
937777002163	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319
937777002164	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
937777002165	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
937777002166	Domain of unknown function DUF21; Region: DUF21; pfam01595
937777002167	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
937777002168	Transporter associated domain; Region: CorC_HlyC; smart01091
937777002169	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
937777002170	active site
937777002171	catalytic motif [active]
937777002172	Zn binding site [ion binding]; other site
937777002173	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
937777002174	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
937777002175	generic binding surface II; other site
937777002176	ssDNA binding site; other site
937777002177	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
937777002178	ATP binding site [chemical binding]; other site
937777002179	putative Mg++ binding site [ion binding]; other site
937777002180	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
937777002181	nucleotide binding region [chemical binding]; other site
937777002182	ATP-binding site [chemical binding]; other site
937777002183	Protein of unknown function (DUF2572); Region: DUF2572; pfam10833
937777002184	short chain dehydrogenase; Provisional; Region: PRK06197
937777002185	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
937777002186	putative NAD(P) binding site [chemical binding]; other site
937777002187	active site
937777002188	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
937777002189	Response regulator receiver domain; Region: Response_reg; pfam00072
937777002190	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777002191	active site
937777002192	phosphorylation site [posttranslational modification]
937777002193	intermolecular recognition site; other site
937777002194	dimerization interface [polypeptide binding]; other site
937777002195	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
937777002196	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
937777002197	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
937777002198	dimerization interface [polypeptide binding]; other site
937777002199	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
937777002200	dimer interface [polypeptide binding]; other site
937777002201	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
937777002202	putative CheW interface [polypeptide binding]; other site
937777002203	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
937777002204	dimerization interface [polypeptide binding]; other site
937777002205	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
937777002206	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
937777002207	dimer interface [polypeptide binding]; other site
937777002208	putative CheW interface [polypeptide binding]; other site
937777002209	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
937777002210	putative binding surface; other site
937777002211	active site
937777002212	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
937777002213	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777002214	ATP binding site [chemical binding]; other site
937777002215	Mg2+ binding site [ion binding]; other site
937777002216	G-X-G motif; other site
937777002217	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
937777002218	Response regulator receiver domain; Region: Response_reg; pfam00072
937777002219	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777002220	active site
937777002221	phosphorylation site [posttranslational modification]
937777002222	intermolecular recognition site; other site
937777002223	dimerization interface [polypeptide binding]; other site
937777002224	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777002225	phosphorylation site [posttranslational modification]
937777002226	intermolecular recognition site; other site
937777002227	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
937777002228	Response regulator receiver domain; Region: Response_reg; pfam00072
937777002229	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777002230	active site
937777002231	phosphorylation site [posttranslational modification]
937777002232	intermolecular recognition site; other site
937777002233	dimerization interface [polypeptide binding]; other site
937777002234	Roadblock/LC7 domain; Region: Robl_LC7; smart00960
937777002235	CHRD domain; Region: CHRD; cl06473
937777002236	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
937777002237	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
937777002238	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
937777002239	ATP binding site [chemical binding]; other site
937777002240	putative Mg++ binding site [ion binding]; other site
937777002241	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
937777002242	nucleotide binding region [chemical binding]; other site
937777002243	ATP-binding site [chemical binding]; other site
937777002244	TRCF domain; Region: TRCF; pfam03461
937777002245	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
937777002246	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
937777002247	substrate binding site [chemical binding]; other site
937777002248	hexamer interface [polypeptide binding]; other site
937777002249	metal binding site [ion binding]; metal-binding site
937777002250	2-phosphosulfolactate phosphatase; Provisional; Region: PRK14100
937777002251	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029
937777002252	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
937777002253	tetramer (dimer of dimers) interface [polypeptide binding]; other site
937777002254	active site
937777002255	dimer interface [polypeptide binding]; other site
937777002256	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
937777002257	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
937777002258	catalytic triad [active]
937777002259	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
937777002260	intersubunit interface [polypeptide binding]; other site
937777002261	active site
937777002262	catalytic residue [active]
937777002263	Maf-like protein; Region: Maf; pfam02545
937777002264	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
937777002265	active site
937777002266	dimer interface [polypeptide binding]; other site
937777002267	rod shape-determining protein MreC; Provisional; Region: PRK13922
937777002268	rod shape-determining protein MreC; Region: MreC; pfam04085
937777002269	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
937777002270	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
937777002271	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
937777002272	H+ Antiporter protein; Region: 2A0121; TIGR00900
937777002273	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
937777002274	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
937777002275	RNA/DNA hybrid binding site [nucleotide binding]; other site
937777002276	active site
937777002277	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
937777002278	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777002279	active site
937777002280	phosphorylation site [posttranslational modification]
937777002281	intermolecular recognition site; other site
937777002282	dimerization interface [polypeptide binding]; other site
937777002283	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777002284	dimer interface [polypeptide binding]; other site
937777002285	phosphorylation site [posttranslational modification]
937777002286	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777002287	ATP binding site [chemical binding]; other site
937777002288	Mg2+ binding site [ion binding]; other site
937777002289	G-X-G motif; other site
937777002290	Tic20-like protein; Region: Tic20; pfam09685
937777002291	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
937777002292	hydrophobic ligand binding site; other site
937777002293	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
937777002294	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
937777002295	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
937777002296	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
937777002297	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
937777002298	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359
937777002299	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
937777002300	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
937777002301	putative active site [active]
937777002302	epoxyqueuosine reductase; Region: TIGR00276
937777002303	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
937777002304	4Fe-4S binding domain; Region: Fer4_6; pfam12837
937777002305	HEAT repeat; Region: HEAT; pfam02985
937777002306	SnoaL-like domain; Region: SnoaL_2; pfam12680
937777002307	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
937777002308	thymidylate kinase; Validated; Region: tmk; PRK00698
937777002309	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
937777002310	TMP-binding site; other site
937777002311	ATP-binding site [chemical binding]; other site
937777002312	Uncharacterized conserved protein [Function unknown]; Region: COG0327
937777002313	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
937777002314	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
937777002315	dimer interface [polypeptide binding]; other site
937777002316	putative metal binding site [ion binding]; other site
937777002317	Predicted transcriptional regulators [Transcription]; Region: COG1378
937777002318	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
937777002319	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
937777002320	putative active site [active]
937777002321	catalytic site [active]
937777002322	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
937777002323	C-terminal peptidase (prc); Region: prc; TIGR00225
937777002324	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
937777002325	protein binding site [polypeptide binding]; other site
937777002326	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
937777002327	Catalytic dyad [active]
937777002328	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
937777002329	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
937777002330	Walker A/P-loop; other site
937777002331	ATP binding site [chemical binding]; other site
937777002332	Q-loop/lid; other site
937777002333	ABC transporter signature motif; other site
937777002334	Walker B; other site
937777002335	D-loop; other site
937777002336	H-loop/switch region; other site
937777002337	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
937777002338	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364
937777002339	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
937777002340	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
937777002341	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
937777002342	Peptidase family M23; Region: Peptidase_M23; pfam01551
937777002343	Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228
937777002344	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
937777002345	KH domain; Region: KH_4; pfam13083
937777002346	G-X-X-G motif; other site
937777002347	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13829
937777002348	RimM N-terminal domain; Region: RimM; pfam01782
937777002349	PRC-barrel domain; Region: PRC; pfam05239
937777002350	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
937777002351	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
937777002352	DNA gyrase subunit A; Validated; Region: PRK05560
937777002353	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
937777002354	CAP-like domain; other site
937777002355	active site
937777002356	primary dimer interface [polypeptide binding]; other site
937777002357	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
937777002358	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
937777002359	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
937777002360	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
937777002361	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
937777002362	CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918
937777002363	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
937777002364	ligand binding site [chemical binding]; other site
937777002365	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
937777002366	non-specific DNA interactions [nucleotide binding]; other site
937777002367	DNA binding site [nucleotide binding]
937777002368	sequence specific DNA binding site [nucleotide binding]; other site
937777002369	putative cAMP binding site [chemical binding]; other site
937777002370	ferredoxin-NADP+ reductase; Region: PLN02852
937777002371	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
937777002372	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
937777002373	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
937777002374	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777002375	PAS domain; Region: PAS_9; pfam13426
937777002376	putative active site [active]
937777002377	heme pocket [chemical binding]; other site
937777002378	PAS fold; Region: PAS_4; pfam08448
937777002379	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
937777002380	PAS domain; Region: PAS; smart00091
937777002381	GAF domain; Region: GAF_3; pfam13492
937777002382	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777002383	dimer interface [polypeptide binding]; other site
937777002384	phosphorylation site [posttranslational modification]
937777002385	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777002386	ATP binding site [chemical binding]; other site
937777002387	Mg2+ binding site [ion binding]; other site
937777002388	G-X-G motif; other site
937777002389	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
937777002390	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
937777002391	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
937777002392	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
937777002393	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
937777002394	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
937777002395	dimerization interface [polypeptide binding]; other site
937777002396	ligand binding site [chemical binding]; other site
937777002397	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
937777002398	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
937777002399	TM-ABC transporter signature motif; other site
937777002400	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
937777002401	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
937777002402	TM-ABC transporter signature motif; other site
937777002403	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
937777002404	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
937777002405	Walker A/P-loop; other site
937777002406	ATP binding site [chemical binding]; other site
937777002407	Q-loop/lid; other site
937777002408	ABC transporter signature motif; other site
937777002409	Walker B; other site
937777002410	D-loop; other site
937777002411	H-loop/switch region; other site
937777002412	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
937777002413	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
937777002414	Walker A/P-loop; other site
937777002415	ATP binding site [chemical binding]; other site
937777002416	Q-loop/lid; other site
937777002417	ABC transporter signature motif; other site
937777002418	Walker B; other site
937777002419	D-loop; other site
937777002420	H-loop/switch region; other site
937777002421	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
937777002422	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
937777002423	peptide binding site [polypeptide binding]; other site
937777002424	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
937777002425	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777002426	dimer interface [polypeptide binding]; other site
937777002427	conserved gate region; other site
937777002428	putative PBP binding loops; other site
937777002429	ABC-ATPase subunit interface; other site
937777002430	dipeptide transporter; Provisional; Region: PRK10913
937777002431	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777002432	dimer interface [polypeptide binding]; other site
937777002433	conserved gate region; other site
937777002434	putative PBP binding loops; other site
937777002435	ABC-ATPase subunit interface; other site
937777002436	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
937777002437	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
937777002438	minor groove reading motif; other site
937777002439	helix-hairpin-helix signature motif; other site
937777002440	substrate binding pocket [chemical binding]; other site
937777002441	active site
937777002442	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
937777002443	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
937777002444	Major Facilitator Superfamily; Region: MFS_1; pfam07690
937777002445	putative substrate translocation pore; other site
937777002446	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
937777002447	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
937777002448	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
937777002449	Hemerythrin-like domain; Region: Hr-like; cd12108
937777002450	Fe binding site [ion binding]; other site
937777002451	Putative zinc ribbon domain; Region: DUF164; pfam02591
937777002452	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
937777002453	S-adenosylmethionine binding site [chemical binding]; other site
937777002454	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
937777002455	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
937777002456	dimer interface [polypeptide binding]; other site
937777002457	active site
937777002458	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
937777002459	dimer interface [polypeptide binding]; other site
937777002460	active site
937777002461	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
937777002462	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825
937777002463	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
937777002464	FOG: CBS domain [General function prediction only]; Region: COG0517
937777002465	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
937777002466	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
937777002467	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
937777002468	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
937777002469	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
937777002470	active site
937777002471	HIGH motif; other site
937777002472	dimer interface [polypeptide binding]; other site
937777002473	KMSKS motif; other site
937777002474	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
937777002475	B12 binding site [chemical binding]; other site
937777002476	cobalt ligand [ion binding]; other site
937777002477	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
937777002478	butyrate kinase; Provisional; Region: PRK03011
937777002479	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
937777002480	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
937777002481	protein binding site [polypeptide binding]; other site
937777002482	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
937777002483	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
937777002484	active site
937777002485	NTP binding site [chemical binding]; other site
937777002486	metal binding triad [ion binding]; metal-binding site
937777002487	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
937777002488	putative substrate binding region [chemical binding]; other site
937777002489	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
937777002490	Peptidase family M50; Region: Peptidase_M50; pfam02163
937777002491	active site
937777002492	putative substrate binding region [chemical binding]; other site
937777002493	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
937777002494	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
937777002495	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
937777002496	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
937777002497	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
937777002498	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
937777002499	active site
937777002500	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
937777002501	EamA-like transporter family; Region: EamA; pfam00892
937777002502	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
937777002503	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
937777002504	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
937777002505	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777002506	active site
937777002507	phosphorylation site [posttranslational modification]
937777002508	intermolecular recognition site; other site
937777002509	dimerization interface [polypeptide binding]; other site
937777002510	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
937777002511	DNA binding site [nucleotide binding]
937777002512	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
937777002513	HAMP domain; Region: HAMP; pfam00672
937777002514	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777002515	dimer interface [polypeptide binding]; other site
937777002516	phosphorylation site [posttranslational modification]
937777002517	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777002518	ATP binding site [chemical binding]; other site
937777002519	Mg2+ binding site [ion binding]; other site
937777002520	G-X-G motif; other site
937777002521	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
937777002522	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777002523	active site
937777002524	phosphorylation site [posttranslational modification]
937777002525	intermolecular recognition site; other site
937777002526	dimerization interface [polypeptide binding]; other site
937777002527	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
937777002528	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
937777002529	Transcriptional regulators [Transcription]; Region: PurR; COG1609
937777002530	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
937777002531	DNA binding site [nucleotide binding]
937777002532	domain linker motif; other site
937777002533	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
937777002534	galactokinase; Provisional; Region: PRK05101
937777002535	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
937777002536	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
937777002537	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
937777002538	active site
937777002539	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
937777002540	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
937777002541	dimer interface [polypeptide binding]; other site
937777002542	active site
937777002543	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
937777002544	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
937777002545	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
937777002546	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
937777002547	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777002548	dimer interface [polypeptide binding]; other site
937777002549	conserved gate region; other site
937777002550	putative PBP binding loops; other site
937777002551	ABC-ATPase subunit interface; other site
937777002552	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777002553	dimer interface [polypeptide binding]; other site
937777002554	conserved gate region; other site
937777002555	putative PBP binding loops; other site
937777002556	ABC-ATPase subunit interface; other site
937777002557	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
937777002558	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
937777002559	Transcriptional regulators [Transcription]; Region: PurR; COG1609
937777002560	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
937777002561	DNA binding site [nucleotide binding]
937777002562	domain linker motif; other site
937777002563	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
937777002564	dimerization interface [polypeptide binding]; other site
937777002565	ligand binding site [chemical binding]; other site
937777002566	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
937777002567	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
937777002568	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
937777002569	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
937777002570	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
937777002571	active site
937777002572	HIGH motif; other site
937777002573	nucleotide binding site [chemical binding]; other site
937777002574	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
937777002575	active site
937777002576	KMSKS motif; other site
937777002577	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
937777002578	tRNA binding surface [nucleotide binding]; other site
937777002579	anticodon binding site; other site
937777002580	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
937777002581	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
937777002582	nudix motif; other site
937777002583	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
937777002584	MPT binding site; other site
937777002585	trimer interface [polypeptide binding]; other site
937777002586	Protein of unknown function (DUF721); Region: DUF721; cl02324
937777002587	recombination protein F; Provisional; Region: recF; PRK14079
937777002588	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
937777002589	Walker A/P-loop; other site
937777002590	ATP binding site [chemical binding]; other site
937777002591	Q-loop/lid; other site
937777002592	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
937777002593	ABC transporter signature motif; other site
937777002594	Walker B; other site
937777002595	D-loop; other site
937777002596	H-loop/switch region; other site
937777002597	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
937777002598	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
937777002599	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
937777002600	putative substrate binding pocket [chemical binding]; other site
937777002601	dimer interface [polypeptide binding]; other site
937777002602	phosphate binding site [ion binding]; other site
937777002603	Domon-like ligand-binding domains; Region: DOMON_like; cl14783
937777002604	putative ligand binding site [chemical binding]; other site
937777002605	EamA-like transporter family; Region: EamA; pfam00892
937777002606	EamA-like transporter family; Region: EamA; pfam00892
937777002607	Protein of unknown function (DUF4127); Region: DUF4127; pfam13552
937777002608	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
937777002609	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
937777002610	FtsX-like permease family; Region: FtsX; pfam02687
937777002611	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
937777002612	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
937777002613	Walker A/P-loop; other site
937777002614	ATP binding site [chemical binding]; other site
937777002615	Q-loop/lid; other site
937777002616	ABC transporter signature motif; other site
937777002617	Walker B; other site
937777002618	D-loop; other site
937777002619	H-loop/switch region; other site
937777002620	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
937777002621	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
937777002622	active site
937777002623	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
937777002624	dimer interface [polypeptide binding]; other site
937777002625	substrate binding site [chemical binding]; other site
937777002626	catalytic residues [active]
937777002627	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
937777002628	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
937777002629	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
937777002630	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
937777002631	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
937777002632	glutamine binding [chemical binding]; other site
937777002633	catalytic triad [active]
937777002634	anthranilate synthase component I; Provisional; Region: PRK13565
937777002635	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
937777002636	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
937777002637	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
937777002638	putative active site [active]
937777002639	nucleotide binding site [chemical binding]; other site
937777002640	nudix motif; other site
937777002641	putative metal binding site [ion binding]; other site
937777002642	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
937777002643	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
937777002644	active site
937777002645	FMN binding site [chemical binding]; other site
937777002646	substrate binding site [chemical binding]; other site
937777002647	homotetramer interface [polypeptide binding]; other site
937777002648	catalytic residue [active]
937777002649	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
937777002650	Major Facilitator Superfamily; Region: MFS_1; pfam07690
937777002651	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
937777002652	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
937777002653	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
937777002654	TPP-binding site; other site
937777002655	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
937777002656	PYR/PP interface [polypeptide binding]; other site
937777002657	dimer interface [polypeptide binding]; other site
937777002658	TPP binding site [chemical binding]; other site
937777002659	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
937777002660	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
937777002661	putative homodimer interface [polypeptide binding]; other site
937777002662	putative active site pocket [active]
937777002663	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
937777002664	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
937777002665	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
937777002666	active site
937777002667	catalytic triad [active]
937777002668	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
937777002669	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
937777002670	ATP binding site [chemical binding]; other site
937777002671	putative Mg++ binding site [ion binding]; other site
937777002672	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
937777002673	nucleotide binding region [chemical binding]; other site
937777002674	ATP-binding site [chemical binding]; other site
937777002675	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
937777002676	HRDC domain; Region: HRDC; pfam00570
937777002677	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
937777002678	putative DNA binding site [nucleotide binding]; other site
937777002679	putative Zn2+ binding site [ion binding]; other site
937777002680	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
937777002681	putative catalytic site [active]
937777002682	putative phosphate binding site [ion binding]; other site
937777002683	active site
937777002684	metal binding site A [ion binding]; metal-binding site
937777002685	DNA binding site [nucleotide binding]
937777002686	putative AP binding site [nucleotide binding]; other site
937777002687	putative metal binding site B [ion binding]; other site
937777002688	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
937777002689	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
937777002690	catalytic site [active]
937777002691	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
937777002692	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
937777002693	catalytic residue [active]
937777002694	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
937777002695	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
937777002696	ligand binding site [chemical binding]; other site
937777002697	NAD binding site [chemical binding]; other site
937777002698	dimerization interface [polypeptide binding]; other site
937777002699	catalytic site [active]
937777002700	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
937777002701	putative L-serine binding site [chemical binding]; other site
937777002702	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
937777002703	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
937777002704	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
937777002705	Peptidase family M23; Region: Peptidase_M23; pfam01551
937777002706	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
937777002707	putative active site [active]
937777002708	dimerization interface [polypeptide binding]; other site
937777002709	putative tRNAtyr binding site [nucleotide binding]; other site
937777002710	Domain of unknown function (DUF1844); Region: DUF1844; pfam08899
937777002711	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
937777002712	Fe-S cluster binding site [ion binding]; other site
937777002713	active site
937777002714	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
937777002715	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
937777002716	NlpC/P60 family; Region: NLPC_P60; pfam00877
937777002717	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
937777002718	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
937777002719	Amidase; Region: Amidase; cl11426
937777002720	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
937777002721	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
937777002722	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
937777002723	active site
937777002724	metal binding site [ion binding]; metal-binding site
937777002725	Intracellular proteinase inhibitor; Region: BsuPI; pfam12690
937777002726	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14334
937777002727	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
937777002728	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
937777002729	FeS/SAM binding site; other site
937777002730	Predicted membrane protein [Function unknown]; Region: COG2261
937777002731	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
937777002732	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
937777002733	active site
937777002734	catalytic tetrad [active]
937777002735	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
937777002736	CoenzymeA binding site [chemical binding]; other site
937777002737	subunit interaction site [polypeptide binding]; other site
937777002738	PHB binding site; other site
937777002739	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
937777002740	CoenzymeA binding site [chemical binding]; other site
937777002741	subunit interaction site [polypeptide binding]; other site
937777002742	PHB binding site; other site
937777002743	hypothetical protein; Provisional; Region: PRK08201
937777002744	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
937777002745	metal binding site [ion binding]; metal-binding site
937777002746	putative dimer interface [polypeptide binding]; other site
937777002747	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
937777002748	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
937777002749	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
937777002750	active site
937777002751	metal binding site [ion binding]; metal-binding site
937777002752	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
937777002753	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
937777002754	DNA binding residues [nucleotide binding]
937777002755	putative dimer interface [polypeptide binding]; other site
937777002756	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
937777002757	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
937777002758	DNA binding residues [nucleotide binding]
937777002759	putative dimer interface [polypeptide binding]; other site
937777002760	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
937777002761	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
937777002762	substrate binding site [chemical binding]; other site
937777002763	oxyanion hole (OAH) forming residues; other site
937777002764	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
937777002765	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
937777002766	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
937777002767	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
937777002768	dimer interface [polypeptide binding]; other site
937777002769	motif 1; other site
937777002770	active site
937777002771	motif 2; other site
937777002772	motif 3; other site
937777002773	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
937777002774	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
937777002775	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
937777002776	active site
937777002777	ATP binding site [chemical binding]; other site
937777002778	substrate binding site [chemical binding]; other site
937777002779	The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637
937777002780	dimer interface [polypeptide binding]; other site
937777002781	active site
937777002782	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
937777002783	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
937777002784	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
937777002785	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
937777002786	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
937777002787	hinge; other site
937777002788	active site
937777002789	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
937777002790	Catalytic domain of Protein Kinases; Region: PKc; cd00180
937777002791	active site
937777002792	ATP binding site [chemical binding]; other site
937777002793	substrate binding site [chemical binding]; other site
937777002794	activation loop (A-loop); other site
937777002795	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
937777002796	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
937777002797	Trp docking motif [polypeptide binding]; other site
937777002798	active site
937777002799	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
937777002800	twin arginine translocase protein A; Provisional; Region: tatA; PRK00191
937777002801	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
937777002802	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
937777002803	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
937777002804	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
937777002805	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
937777002806	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
937777002807	sequence-specific DNA binding site [nucleotide binding]; other site
937777002808	salt bridge; other site
937777002809	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
937777002810	cofactor binding site; other site
937777002811	DNA binding site [nucleotide binding]
937777002812	substrate interaction site [chemical binding]; other site
937777002813	Protein of unknown function (DUF1653); Region: DUF1653; cl01949
937777002814	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
937777002815	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
937777002816	active site
937777002817	DNA binding site [nucleotide binding]
937777002818	Int/Topo IB signature motif; other site
937777002819	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
937777002820	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
937777002821	Holin family; Region: Phage_holin_4; cl01989
937777002822	Right handed beta helix region; Region: Beta_helix; pfam13229
937777002823	tape measure domain; Region: tape_meas_nterm; TIGR02675
937777002824	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
937777002825	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
937777002826	Terminase-like family; Region: Terminase_6; pfam03237
937777002827	Phage terminase large subunit; Region: Terminase_3; cl12054
937777002828	Terminase small subunit; Region: Terminase_2; cl01513
937777002829	Terminase small subunit; Region: Terminase_2; cl01513
937777002830	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
937777002831	D5 N terminal like; Region: D5_N; smart00885
937777002832	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
937777002833	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
937777002834	Poxvirus D5 protein-like; Region: Pox_D5; pfam03288
937777002835	AAA domain; Region: AAA_30; pfam13604
937777002836	Family description; Region: UvrD_C_2; pfam13538
937777002837	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
937777002838	sequence-specific DNA binding site [nucleotide binding]; other site
937777002839	salt bridge; other site
937777002840	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
937777002841	non-specific DNA binding site [nucleotide binding]; other site
937777002842	salt bridge; other site
937777002843	sequence-specific DNA binding site [nucleotide binding]; other site
937777002844	Domain of unknown function (DUF955); Region: DUF955; cl01076
937777002845	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
937777002846	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
937777002847	catalytic residues [active]
937777002848	catalytic nucleophile [active]
937777002849	Recombinase; Region: Recombinase; pfam07508
937777002850	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
937777002851	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
937777002852	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
937777002853	dimerization interface [polypeptide binding]; other site
937777002854	domain crossover interface; other site
937777002855	redox-dependent activation switch; other site
937777002856	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
937777002857	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
937777002858	RNA binding surface [nucleotide binding]; other site
937777002859	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
937777002860	active site
937777002861	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
937777002862	superoxide dismutase; Provisional; Region: PRK10925
937777002863	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
937777002864	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
937777002865	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
937777002866	active site
937777002867	(T/H)XGH motif; other site
937777002868	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
937777002869	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
937777002870	S-adenosylmethionine binding site [chemical binding]; other site
937777002871	RDD family; Region: RDD; pfam06271
937777002872	M20 Peptidase acetylornithine deacetylase/acetyl-lysine deacetylase; Region: M20_ArgE_LysK; cd05653
937777002873	acetyl-lysine deacetylase; Provisional; Region: PRK04443
937777002874	metal binding site [ion binding]; metal-binding site
937777002875	putative dimer interface [polypeptide binding]; other site
937777002876	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
937777002877	transmembrane helices; other site
937777002878	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
937777002879	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
937777002880	TrkA-C domain; Region: TrkA_C; pfam02080
937777002881	TrkA-C domain; Region: TrkA_C; pfam02080
937777002882	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
937777002883	Transmembrane secretion effector; Region: MFS_3; pfam05977
937777002884	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
937777002885	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
937777002886	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
937777002887	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
937777002888	NlpC/P60 family; Region: NLPC_P60; pfam00877
937777002889	Cache domain; Region: Cache_1; pfam02743
937777002890	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777002891	dimer interface [polypeptide binding]; other site
937777002892	phosphorylation site [posttranslational modification]
937777002893	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777002894	ATP binding site [chemical binding]; other site
937777002895	Mg2+ binding site [ion binding]; other site
937777002896	G-X-G motif; other site
937777002897	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
937777002898	MPN+ (JAMM) motif; other site
937777002899	Zinc-binding site [ion binding]; other site
937777002900	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
937777002901	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
937777002902	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
937777002903	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
937777002904	Fasciclin domain; Region: Fasciclin; pfam02469
937777002905	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
937777002906	Fasciclin domain; Region: Fasciclin; pfam02469
937777002907	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
937777002908	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
937777002909	Walker A/P-loop; other site
937777002910	ATP binding site [chemical binding]; other site
937777002911	Q-loop/lid; other site
937777002912	ABC transporter signature motif; other site
937777002913	Walker B; other site
937777002914	D-loop; other site
937777002915	H-loop/switch region; other site
937777002916	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
937777002917	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
937777002918	active site
937777002919	catalytic tetrad [active]
937777002920	Response regulator receiver domain; Region: Response_reg; pfam00072
937777002921	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777002922	active site
937777002923	phosphorylation site [posttranslational modification]
937777002924	intermolecular recognition site; other site
937777002925	dimerization interface [polypeptide binding]; other site
937777002926	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777002927	dimer interface [polypeptide binding]; other site
937777002928	phosphorylation site [posttranslational modification]
937777002929	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777002930	ATP binding site [chemical binding]; other site
937777002931	G-X-G motif; other site
937777002932	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
937777002933	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777002934	ATP binding site [chemical binding]; other site
937777002935	Mg2+ binding site [ion binding]; other site
937777002936	G-X-G motif; other site
937777002937	ATP synthase subunit D; Region: ATP-synt_D; cl00613
937777002938	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777002939	dimer interface [polypeptide binding]; other site
937777002940	phosphorylation site [posttranslational modification]
937777002941	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777002942	ATP binding site [chemical binding]; other site
937777002943	Mg2+ binding site [ion binding]; other site
937777002944	G-X-G motif; other site
937777002945	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
937777002946	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
937777002947	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
937777002948	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
937777002949	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
937777002950	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
937777002951	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
937777002952	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
937777002953	cell division topological specificity factor MinE; Region: minE; TIGR01215
937777002954	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
937777002955	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
937777002956	Switch I; other site
937777002957	Switch II; other site
937777002958	FtsH Extracellular; Region: FtsH_ext; pfam06480
937777002959	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
937777002960	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
937777002961	Walker A motif; other site
937777002962	ATP binding site [chemical binding]; other site
937777002963	Walker B motif; other site
937777002964	arginine finger; other site
937777002965	Peptidase family M41; Region: Peptidase_M41; pfam01434
937777002966	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
937777002967	TPR motif; other site
937777002968	binding surface
937777002969	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
937777002970	oligomerization interface [polypeptide binding]; other site
937777002971	active site
937777002972	metal binding site [ion binding]; metal-binding site
937777002973	Protein of unknown function (DUF420); Region: DUF420; cl00989
937777002974	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
937777002975	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
937777002976	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
937777002977	UbiA prenyltransferase family; Region: UbiA; pfam01040
937777002978	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
937777002979	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
937777002980	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
937777002981	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
937777002982	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
937777002983	Subunit I/III interface [polypeptide binding]; other site
937777002984	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
937777002985	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
937777002986	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
937777002987	Cu(I) binding site [ion binding]; other site
937777002988	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
937777002989	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
937777002990	Walker A motif; other site
937777002991	ATP binding site [chemical binding]; other site
937777002992	Walker B motif; other site
937777002993	arginine finger; other site
937777002994	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
937777002995	DNA primase; Validated; Region: dnaG; PRK05667
937777002996	CHC2 zinc finger; Region: zf-CHC2; pfam01807
937777002997	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
937777002998	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
937777002999	active site
937777003000	metal binding site [ion binding]; metal-binding site
937777003001	interdomain interaction site; other site
937777003002	Uncharacterized ACR, COG1678; Region: DUF179; cl00731
937777003003	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
937777003004	Found in ATP-dependent protease La (LON); Region: LON; smart00464
937777003005	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
937777003006	Walker A motif; other site
937777003007	ATP binding site [chemical binding]; other site
937777003008	Walker B motif; other site
937777003009	arginine finger; other site
937777003010	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
937777003011	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
937777003012	histidinol-phosphatase; Provisional; Region: PRK07328
937777003013	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
937777003014	active site
937777003015	dimer interface [polypeptide binding]; other site
937777003016	hypothetical protein; Provisional; Region: PRK08609
937777003017	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
937777003018	active site
937777003019	primer binding site [nucleotide binding]; other site
937777003020	NTP  binding site [chemical binding]; other site
937777003021	metal binding triad [ion binding]; metal-binding site
937777003022	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
937777003023	active site
937777003024	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
937777003025	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
937777003026	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
937777003027	DctM-like transporters; Region: DctM; pfam06808
937777003028	TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665
937777003029	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
937777003030	Chorismate mutase type II; Region: CM_2; cl00693
937777003031	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
937777003032	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
937777003033	twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411
937777003034	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
937777003035	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
937777003036	Substrate binding site; other site
937777003037	Mg++ binding site; other site
937777003038	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
937777003039	active site
937777003040	substrate binding site [chemical binding]; other site
937777003041	CoA binding site [chemical binding]; other site
937777003042	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
937777003043	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
937777003044	Protein of unknown function (DUF456); Region: DUF456; cl01069
937777003045	putative acyltransferase; Provisional; Region: PRK05790
937777003046	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
937777003047	dimer interface [polypeptide binding]; other site
937777003048	active site
937777003049	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
937777003050	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
937777003051	active site
937777003052	catalytic residues [active]
937777003053	metal binding site [ion binding]; metal-binding site
937777003054	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
937777003055	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
937777003056	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
937777003057	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
937777003058	signal recognition particle protein; Provisional; Region: PRK10867
937777003059	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
937777003060	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
937777003061	P loop; other site
937777003062	GTP binding site [chemical binding]; other site
937777003063	Signal peptide binding domain; Region: SRP_SPB; pfam02978
937777003064	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
937777003065	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
937777003066	DDE superfamily endonuclease; Region: DDE_4; pfam13359
937777003067	Predicted membrane protein [Function unknown]; Region: COG2323
937777003068	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
937777003069	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777003070	active site
937777003071	phosphorylation site [posttranslational modification]
937777003072	intermolecular recognition site; other site
937777003073	dimerization interface [polypeptide binding]; other site
937777003074	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
937777003075	DNA binding site [nucleotide binding]
937777003076	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
937777003077	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777003078	active site
937777003079	phosphorylation site [posttranslational modification]
937777003080	intermolecular recognition site; other site
937777003081	dimerization interface [polypeptide binding]; other site
937777003082	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
937777003083	DNA binding site [nucleotide binding]
937777003084	Response regulator receiver domain; Region: Response_reg; pfam00072
937777003085	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777003086	active site
937777003087	phosphorylation site [posttranslational modification]
937777003088	intermolecular recognition site; other site
937777003089	dimerization interface [polypeptide binding]; other site
937777003090	Stress-induced bacterial acidophilic repeat motif; Region: KGG; pfam10685
937777003091	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
937777003092	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777003093	putative active site [active]
937777003094	heme pocket [chemical binding]; other site
937777003095	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777003096	ATP binding site [chemical binding]; other site
937777003097	Mg2+ binding site [ion binding]; other site
937777003098	G-X-G motif; other site
937777003099	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
937777003100	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
937777003101	transaldolase-like protein; Provisional; Region: PTZ00411
937777003102	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
937777003103	active site
937777003104	dimer interface [polypeptide binding]; other site
937777003105	catalytic residue [active]
937777003106	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
937777003107	active site
937777003108	Erythromycin esterase; Region: Erythro_esteras; pfam05139
937777003109	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
937777003110	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
937777003111	Cobalamin-5-phosphate synthase [Coenzyme metabolism]; Region: CobS; COG0368
937777003112	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
937777003113	catalytic core [active]
937777003114	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
937777003115	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
937777003116	active site
937777003117	homotetramer interface [polypeptide binding]; other site
937777003118	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
937777003119	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
937777003120	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
937777003121	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
937777003122	putative dimer interface [polypeptide binding]; other site
937777003123	active site pocket [active]
937777003124	putative cataytic base [active]
937777003125	Response regulator receiver domain; Region: Response_reg; pfam00072
937777003126	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777003127	active site
937777003128	phosphorylation site [posttranslational modification]
937777003129	intermolecular recognition site; other site
937777003130	dimerization interface [polypeptide binding]; other site
937777003131	Penicillin amidase; Region: Penicil_amidase; pfam01804
937777003132	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
937777003133	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
937777003134	active site
937777003135	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
937777003136	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
937777003137	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
937777003138	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
937777003139	TrkA-C domain; Region: TrkA_C; pfam02080
937777003140	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
937777003141	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
937777003142	TrkA-C domain; Region: TrkA_C; pfam02080
937777003143	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
937777003144	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
937777003145	Int/Topo IB signature motif; other site
937777003146	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
937777003147	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
937777003148	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
937777003149	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
937777003150	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
937777003151	Thymidine phosphorylase [Nucleotide transport and metabolism]; Region: DeoA; COG0213
937777003152	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
937777003153	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
937777003154	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734
937777003155	GTPase Era; Reviewed; Region: era; PRK00089
937777003156	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
937777003157	G1 box; other site
937777003158	GTP/Mg2+ binding site [chemical binding]; other site
937777003159	Switch I region; other site
937777003160	G2 box; other site
937777003161	Switch II region; other site
937777003162	G3 box; other site
937777003163	G4 box; other site
937777003164	G5 box; other site
937777003165	KH domain; Region: KH_2; pfam07650
937777003166	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
937777003167	trimer interface [polypeptide binding]; other site
937777003168	active site
937777003169	Acyltransferase family; Region: Acyl_transf_3; pfam01757
937777003170	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
937777003171	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
937777003172	Coenzyme A binding pocket [chemical binding]; other site
937777003173	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
937777003174	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
937777003175	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
937777003176	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
937777003177	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
937777003178	Walker A/P-loop; other site
937777003179	ATP binding site [chemical binding]; other site
937777003180	Q-loop/lid; other site
937777003181	ABC transporter signature motif; other site
937777003182	Walker B; other site
937777003183	D-loop; other site
937777003184	H-loop/switch region; other site
937777003185	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
937777003186	hypothetical protein; Reviewed; Region: PRK12497
937777003187	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
937777003188	active site
937777003189	catalytic triad [active]
937777003190	oxyanion hole [active]
937777003191	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
937777003192	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
937777003193	malate dehydrogenase; Provisional; Region: PRK05442
937777003194	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
937777003195	NAD(P) binding site [chemical binding]; other site
937777003196	dimer interface [polypeptide binding]; other site
937777003197	malate binding site [chemical binding]; other site
937777003198	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
937777003199	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
937777003200	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
937777003201	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
937777003202	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
937777003203	amidase catalytic site [active]
937777003204	Zn binding residues [ion binding]; other site
937777003205	substrate binding site [chemical binding]; other site
937777003206	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
937777003207	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
937777003208	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
937777003209	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
937777003210	nudix motif; other site
937777003211	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
937777003212	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
937777003213	lipoyl synthase; Provisional; Region: PRK05481
937777003214	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
937777003215	FeS/SAM binding site; other site
937777003216	MFS/sugar transport protein; Region: MFS_2; pfam13347
937777003217	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
937777003218	putative substrate translocation pore; other site
937777003219	ERF superfamily; Region: ERF; pfam04404
937777003220	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
937777003221	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
937777003222	active site
937777003223	stage V sporulation protein K; Region: spore_V_K; TIGR02881
937777003224	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
937777003225	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
937777003226	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
937777003227	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
937777003228	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
937777003229	DNA binding residues [nucleotide binding]
937777003230	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
937777003231	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777003232	active site
937777003233	intermolecular recognition site; other site
937777003234	dimerization interface [polypeptide binding]; other site
937777003235	OsmC-like protein; Region: OsmC; pfam02566
937777003236	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
937777003237	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
937777003238	Walker A/P-loop; other site
937777003239	ATP binding site [chemical binding]; other site
937777003240	Q-loop/lid; other site
937777003241	ABC transporter signature motif; other site
937777003242	Walker B; other site
937777003243	D-loop; other site
937777003244	H-loop/switch region; other site
937777003245	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
937777003246	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
937777003247	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
937777003248	Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney,  using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers; Region: iodotyrosine_dehalogenase; cd02144
937777003249	putative FMN binding site [chemical binding]; other site
937777003250	putative dimer interface [polypeptide binding]; other site
937777003251	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
937777003252	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
937777003253	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
937777003254	mercuric reductase; Validated; Region: PRK06370
937777003255	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
937777003256	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
937777003257	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
937777003258	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
937777003259	ligand binding site [chemical binding]; other site
937777003260	flexible hinge region; other site
937777003261	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
937777003262	Domain of unknown function (DUF427); Region: DUF427; pfam04248
937777003263	Protein of unknown function (DUF3179); Region: DUF3179; pfam11376
937777003264	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
937777003265	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
937777003266	catalytic residues [active]
937777003267	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
937777003268	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
937777003269	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
937777003270	MoaE interaction surface [polypeptide binding]; other site
937777003271	MoeB interaction surface [polypeptide binding]; other site
937777003272	thiocarboxylated glycine; other site
937777003273	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
937777003274	MoaE homodimer interface [polypeptide binding]; other site
937777003275	MoaD interaction [polypeptide binding]; other site
937777003276	active site residues [active]
937777003277	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
937777003278	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
937777003279	FeS/SAM binding site; other site
937777003280	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
937777003281	Protein of unknown function (DUF1440); Region: DUF1440; cl01380
937777003282	MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738
937777003283	Protein of unknown function (DUF1440); Region: DUF1440; cl01380
937777003284	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
937777003285	DsrE/DsrF-like family; Region: DrsE; cl00672
937777003286	short chain dehydrogenase; Provisional; Region: PRK09072
937777003287	classical (c) SDRs; Region: SDR_c; cd05233
937777003288	NAD(P) binding site [chemical binding]; other site
937777003289	active site
937777003290	Predicted amidohydrolase [General function prediction only]; Region: COG0388
937777003291	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
937777003292	putative active site [active]
937777003293	catalytic triad [active]
937777003294	putative dimer interface [polypeptide binding]; other site
937777003295	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
937777003296	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
937777003297	metal binding site [ion binding]; metal-binding site
937777003298	dimer interface [polypeptide binding]; other site
937777003299	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
937777003300	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
937777003301	peptide binding site [polypeptide binding]; other site
937777003302	Uncharacterized conserved protein [Function unknown]; Region: COG3342
937777003303	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
937777003304	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
937777003305	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777003306	dimer interface [polypeptide binding]; other site
937777003307	conserved gate region; other site
937777003308	putative PBP binding loops; other site
937777003309	ABC-ATPase subunit interface; other site
937777003310	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
937777003311	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777003312	dimer interface [polypeptide binding]; other site
937777003313	conserved gate region; other site
937777003314	putative PBP binding loops; other site
937777003315	ABC-ATPase subunit interface; other site
937777003316	Uncharacterized conserved protein [Function unknown]; Region: COG0397
937777003317	hypothetical protein; Validated; Region: PRK00029
937777003318	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
937777003319	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
937777003320	DDE superfamily endonuclease; Region: DDE_4; pfam13359
937777003321	WYL domain; Region: WYL; pfam13280
937777003322	Phosphotransferase enzyme family; Region: APH; pfam01636
937777003323	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
937777003324	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
937777003325	Predicted acetyltransferase [General function prediction only]; Region: COG2388
937777003326	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
937777003327	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
937777003328	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
937777003329	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
937777003330	active site
937777003331	dimer interface [polypeptide binding]; other site
937777003332	motif 1; other site
937777003333	motif 2; other site
937777003334	motif 3; other site
937777003335	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
937777003336	anticodon binding site; other site
937777003337	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
937777003338	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
937777003339	metal binding site [ion binding]; metal-binding site
937777003340	active site
937777003341	I-site; other site
937777003342	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
937777003343	catalytic residues [active]
937777003344	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
937777003345	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
937777003346	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
937777003347	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
937777003348	RNase E interface [polypeptide binding]; other site
937777003349	trimer interface [polypeptide binding]; other site
937777003350	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
937777003351	RNase E interface [polypeptide binding]; other site
937777003352	trimer interface [polypeptide binding]; other site
937777003353	active site
937777003354	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
937777003355	putative nucleic acid binding region [nucleotide binding]; other site
937777003356	G-X-X-G motif; other site
937777003357	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
937777003358	RNA binding site [nucleotide binding]; other site
937777003359	domain interface; other site
937777003360	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
937777003361	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
937777003362	putative substrate binding site [chemical binding]; other site
937777003363	putative ATP binding site [chemical binding]; other site
937777003364	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
937777003365	PRC-barrel domain; Region: PRC; pfam05239
937777003366	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
937777003367	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777003368	active site
937777003369	phosphorylation site [posttranslational modification]
937777003370	intermolecular recognition site; other site
937777003371	dimerization interface [polypeptide binding]; other site
937777003372	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
937777003373	DNA binding site [nucleotide binding]
937777003374	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
937777003375	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
937777003376	dimerization interface [polypeptide binding]; other site
937777003377	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777003378	dimer interface [polypeptide binding]; other site
937777003379	phosphorylation site [posttranslational modification]
937777003380	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777003381	ATP binding site [chemical binding]; other site
937777003382	Mg2+ binding site [ion binding]; other site
937777003383	G-X-G motif; other site
937777003384	ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448
937777003385	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
937777003386	ligand binding site; other site
937777003387	oligomer interface; other site
937777003388	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
937777003389	dimer interface [polypeptide binding]; other site
937777003390	N-terminal domain interface [polypeptide binding]; other site
937777003391	sulfate 1 binding site; other site
937777003392	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
937777003393	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777003394	dimer interface [polypeptide binding]; other site
937777003395	conserved gate region; other site
937777003396	putative PBP binding loops; other site
937777003397	ABC-ATPase subunit interface; other site
937777003398	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
937777003399	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
937777003400	Walker A/P-loop; other site
937777003401	ATP binding site [chemical binding]; other site
937777003402	Q-loop/lid; other site
937777003403	ABC transporter signature motif; other site
937777003404	Walker B; other site
937777003405	D-loop; other site
937777003406	H-loop/switch region; other site
937777003407	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
937777003408	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
937777003409	substrate binding pocket [chemical binding]; other site
937777003410	membrane-bound complex binding site; other site
937777003411	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
937777003412	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
937777003413	active site
937777003414	metal binding site [ion binding]; metal-binding site
937777003415	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
937777003416	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
937777003417	ATP binding site [chemical binding]; other site
937777003418	active site
937777003419	substrate binding site [chemical binding]; other site
937777003420	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
937777003421	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
937777003422	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
937777003423	putative active site [active]
937777003424	catalytic triad [active]
937777003425	DinB superfamily; Region: DinB_2; pfam12867
937777003426	DinB superfamily; Region: DinB_2; pfam12867
937777003427	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
937777003428	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
937777003429	dimerization interface [polypeptide binding]; other site
937777003430	ATP binding site [chemical binding]; other site
937777003431	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
937777003432	dimerization interface [polypeptide binding]; other site
937777003433	ATP binding site [chemical binding]; other site
937777003434	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
937777003435	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
937777003436	active site
937777003437	tetramer interface [polypeptide binding]; other site
937777003438	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
937777003439	active site
937777003440	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
937777003441	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
937777003442	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
937777003443	PRC-barrel domain; Region: PRC; pfam05239
937777003444	Domain of unknown function (DUF2382); Region: DUF2382; pfam09557
937777003445	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
937777003446	Major Facilitator Superfamily; Region: MFS_1; pfam07690
937777003447	putative substrate translocation pore; other site
937777003448	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
937777003449	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
937777003450	GAF domain; Region: GAF; pfam01590
937777003451	PAS domain; Region: PAS_9; pfam13426
937777003452	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777003453	putative active site [active]
937777003454	heme pocket [chemical binding]; other site
937777003455	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
937777003456	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
937777003457	metal binding site [ion binding]; metal-binding site
937777003458	active site
937777003459	I-site; other site
937777003460	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
937777003461	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
937777003462	classical (c) SDRs; Region: SDR_c; cd05233
937777003463	NAD(P) binding site [chemical binding]; other site
937777003464	active site
937777003465	Protein of unknown function DUF72; Region: DUF72; pfam01904
937777003466	phosphoglucomutase; Validated; Region: PRK07564
937777003467	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
937777003468	active site
937777003469	substrate binding site [chemical binding]; other site
937777003470	metal binding site [ion binding]; metal-binding site
937777003471	ChaB; Region: ChaB; cl01887
937777003472	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
937777003473	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
937777003474	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
937777003475	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
937777003476	DNA-binding site [nucleotide binding]; DNA binding site
937777003477	RNA-binding motif; other site
937777003478	Protein of unknown function DUF99; Region: DUF99; pfam01949
937777003479	hypothetical protein; Provisional; Region: PRK00766
937777003480	Domain of unknown function (DUF4383); Region: DUF4383; pfam14325
937777003481	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
937777003482	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
937777003483	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
937777003484	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
937777003485	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
937777003486	Walker A/P-loop; other site
937777003487	ATP binding site [chemical binding]; other site
937777003488	Q-loop/lid; other site
937777003489	ABC transporter signature motif; other site
937777003490	Walker B; other site
937777003491	D-loop; other site
937777003492	H-loop/switch region; other site
937777003493	TOBE domain; Region: TOBE_2; pfam08402
937777003494	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
937777003495	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777003496	dimer interface [polypeptide binding]; other site
937777003497	conserved gate region; other site
937777003498	ABC-ATPase subunit interface; other site
937777003499	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
937777003500	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
937777003501	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
937777003502	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777003503	active site
937777003504	phosphorylation site [posttranslational modification]
937777003505	intermolecular recognition site; other site
937777003506	dimerization interface [polypeptide binding]; other site
937777003507	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
937777003508	DNA binding residues [nucleotide binding]
937777003509	dimerization interface [polypeptide binding]; other site
937777003510	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
937777003511	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
937777003512	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
937777003513	Cytochrome c; Region: Cytochrom_C; pfam00034
937777003514	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
937777003515	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
937777003516	iron-sulfur cluster [ion binding]; other site
937777003517	[2Fe-2S] cluster binding site [ion binding]; other site
937777003518	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
937777003519	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
937777003520	interchain domain interface [polypeptide binding]; other site
937777003521	intrachain domain interface; other site
937777003522	heme bL binding site [chemical binding]; other site
937777003523	heme bH binding site [chemical binding]; other site
937777003524	Qo binding site; other site
937777003525	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
937777003526	intrachain domain interface; other site
937777003527	Qo binding site; other site
937777003528	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
937777003529	active site
937777003530	catalytic triad [active]
937777003531	oxyanion hole [active]
937777003532	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
937777003533	active site
937777003534	catalytic triad [active]
937777003535	oxyanion hole [active]
937777003536	hypothetical protein; Validated; Region: PRK00110
937777003537	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
937777003538	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
937777003539	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
937777003540	ribulokinase; Provisional; Region: PRK04123
937777003541	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
937777003542	N- and C-terminal domain interface [polypeptide binding]; other site
937777003543	active site
937777003544	MgATP binding site [chemical binding]; other site
937777003545	catalytic site [active]
937777003546	metal binding site [ion binding]; metal-binding site
937777003547	carbohydrate binding site [chemical binding]; other site
937777003548	homodimer interface [polypeptide binding]; other site
937777003549	L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557
937777003550	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
937777003551	intersubunit interface [polypeptide binding]; other site
937777003552	active site
937777003553	Zn2+ binding site [ion binding]; other site
937777003554	L-arabinose isomerase; Provisional; Region: PRK02929
937777003555	L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557
937777003556	putative hexamer (dimer of trimers) interface [polypeptide binding]; other site
937777003557	trimer interface [polypeptide binding]; other site
937777003558	putative substrate binding site [chemical binding]; other site
937777003559	putative metal binding site [ion binding]; other site
937777003560	Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998
937777003561	substrate binding site [chemical binding]; other site
937777003562	active site
937777003563	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
937777003564	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
937777003565	NAD(P) binding site [chemical binding]; other site
937777003566	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
937777003567	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
937777003568	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
937777003569	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
937777003570	lac repressor; Reviewed; Region: lacI; PRK09526
937777003571	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
937777003572	DNA binding site [nucleotide binding]
937777003573	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
937777003574	ligand binding site [chemical binding]; other site
937777003575	dimerization interface (open form) [polypeptide binding]; other site
937777003576	dimerization interface (closed form) [polypeptide binding]; other site
937777003577	Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998
937777003578	substrate binding site [chemical binding]; other site
937777003579	active site
937777003580	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
937777003581	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
937777003582	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
937777003583	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777003584	dimer interface [polypeptide binding]; other site
937777003585	conserved gate region; other site
937777003586	putative PBP binding loops; other site
937777003587	ABC-ATPase subunit interface; other site
937777003588	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
937777003589	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777003590	dimer interface [polypeptide binding]; other site
937777003591	conserved gate region; other site
937777003592	putative PBP binding loops; other site
937777003593	ABC-ATPase subunit interface; other site
937777003594	BNR repeat-like domain; Region: BNR_2; pfam13088
937777003595	transketolase; Reviewed; Region: PRK12753
937777003596	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
937777003597	TPP-binding site [chemical binding]; other site
937777003598	dimer interface [polypeptide binding]; other site
937777003599	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
937777003600	PYR/PP interface [polypeptide binding]; other site
937777003601	dimer interface [polypeptide binding]; other site
937777003602	TPP binding site [chemical binding]; other site
937777003603	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
937777003604	transaldolase-like protein; Provisional; Region: PTZ00411
937777003605	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
937777003606	active site
937777003607	catalytic residue [active]
937777003608	alpha-galactosidase; Region: PLN02808; cl17638
937777003609	RNA 2'-phosphotransferase; Reviewed; Region: PRK00819
937777003610	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
937777003611	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
937777003612	Peptidase family M23; Region: Peptidase_M23; pfam01551
937777003613	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
937777003614	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
937777003615	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
937777003616	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777003617	active site
937777003618	phosphorylation site [posttranslational modification]
937777003619	intermolecular recognition site; other site
937777003620	dimerization interface [polypeptide binding]; other site
937777003621	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
937777003622	DNA binding site [nucleotide binding]
937777003623	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
937777003624	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777003625	dimer interface [polypeptide binding]; other site
937777003626	phosphorylation site [posttranslational modification]
937777003627	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777003628	ATP binding site [chemical binding]; other site
937777003629	Mg2+ binding site [ion binding]; other site
937777003630	G-X-G motif; other site
937777003631	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
937777003632	PhoU domain; Region: PhoU; pfam01895
937777003633	PhoU domain; Region: PhoU; pfam01895
937777003634	PBP superfamily domain; Region: PBP_like_2; cl17296
937777003635	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
937777003636	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266
937777003637	putative NAD(P) binding site [chemical binding]; other site
937777003638	structural Zn binding site [ion binding]; other site
937777003639	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710
937777003640	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
937777003641	acyl-activating enzyme (AAE) consensus motif; other site
937777003642	putative AMP binding site [chemical binding]; other site
937777003643	putative active site [active]
937777003644	putative CoA binding site [chemical binding]; other site
937777003645	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
937777003646	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777003647	active site
937777003648	phosphorylation site [posttranslational modification]
937777003649	intermolecular recognition site; other site
937777003650	dimerization interface [polypeptide binding]; other site
937777003651	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
937777003652	Transglycosylase; Region: Transgly; pfam00912
937777003653	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
937777003654	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
937777003655	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
937777003656	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
937777003657	Walker A/P-loop; other site
937777003658	ATP binding site [chemical binding]; other site
937777003659	ABC transporter; Region: ABC_tran; pfam00005
937777003660	Q-loop/lid; other site
937777003661	ABC transporter signature motif; other site
937777003662	Walker B; other site
937777003663	D-loop; other site
937777003664	H-loop/switch region; other site
937777003665	CcmB protein; Region: CcmB; cl17444
937777003666	CcmB protein; Region: CcmB; cl17444
937777003667	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
937777003668	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
937777003669	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
937777003670	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
937777003671	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
937777003672	catalytic residues [active]
937777003673	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
937777003674	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
937777003675	TPR motif; other site
937777003676	TPR repeat; Region: TPR_11; pfam13414
937777003677	binding surface
937777003678	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
937777003679	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
937777003680	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
937777003681	iron-sulfur cluster [ion binding]; other site
937777003682	[2Fe-2S] cluster binding site [ion binding]; other site
937777003683	Threonine dehydrogenase; Region: TDH; cd05281
937777003684	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
937777003685	structural Zn binding site [ion binding]; other site
937777003686	catalytic Zn binding site [ion binding]; other site
937777003687	tetramer interface [polypeptide binding]; other site
937777003688	NADP binding site [chemical binding]; other site
937777003689	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
937777003690	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
937777003691	active site
937777003692	catalytic residues [active]
937777003693	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
937777003694	binding surface
937777003695	TPR motif; other site
937777003696	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
937777003697	dimerization interface [polypeptide binding]; other site
937777003698	metal binding site [ion binding]; metal-binding site
937777003699	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
937777003700	nudix motif; other site
937777003701	ribonuclease E; Reviewed; Region: rne; PRK10811
937777003702	Protein of unknown function (DUF1045); Region: DUF1045; cl15435
937777003703	malate dehydrogenase; Provisional; Region: PRK13529
937777003704	Malic enzyme, N-terminal domain; Region: malic; pfam00390
937777003705	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
937777003706	NAD(P) binding site [chemical binding]; other site
937777003707	Predicted thioesterase [General function prediction only]; Region: COG5496
937777003708	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
937777003709	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
937777003710	dimer interface [polypeptide binding]; other site
937777003711	active site
937777003712	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
937777003713	catalytic core [active]
937777003714	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
937777003715	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
937777003716	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
937777003717	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
937777003718	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
937777003719	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
937777003720	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
937777003721	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
937777003722	Phenylacetic acid degradation B; Region: PaaB; cl01371
937777003723	Phenylacetic acid degradation B; Region: PaaB; cl01371
937777003724	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
937777003725	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
937777003726	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
937777003727	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
937777003728	multidrug resistance protein MdtH; Provisional; Region: PRK11646
937777003729	putative substrate translocation pore; other site
937777003730	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
937777003731	Ferritin-like domain; Region: Ferritin; pfam00210
937777003732	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
937777003733	dimerization interface [polypeptide binding]; other site
937777003734	DPS ferroxidase diiron center [ion binding]; other site
937777003735	ion pore; other site
937777003736	Domain of unknown function (DUF4385); Region: DUF4385; pfam14328
937777003737	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
937777003738	active site
937777003739	metal binding site [ion binding]; metal-binding site
937777003740	Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403
937777003741	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
937777003742	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
937777003743	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
937777003744	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
937777003745	putative active site pocket [active]
937777003746	cleavage site
937777003747	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
937777003748	active site
937777003749	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
937777003750	homodecamer interface [polypeptide binding]; other site
937777003751	GTP cyclohydrolase I; Provisional; Region: PLN03044
937777003752	active site
937777003753	putative catalytic site residues [active]
937777003754	zinc binding site [ion binding]; other site
937777003755	GTP-CH-I/GFRP interaction surface; other site
937777003756	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
937777003757	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
937777003758	GDP-binding site [chemical binding]; other site
937777003759	ACT binding site; other site
937777003760	IMP binding site; other site
937777003761	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
937777003762	e3 binding domain; Region: E3_binding; pfam02817
937777003763	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
937777003764	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
937777003765	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
937777003766	NAD binding site [chemical binding]; other site
937777003767	Phe binding site; other site
937777003768	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
937777003769	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
937777003770	ATP-binding site [chemical binding]; other site
937777003771	Sugar specificity; other site
937777003772	Pyrimidine base specificity; other site
937777003773	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
937777003774	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
937777003775	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
937777003776	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
937777003777	Coenzyme A binding pocket [chemical binding]; other site
937777003778	Predicted integral membrane protein [Function unknown]; Region: COG5652
937777003779	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
937777003780	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
937777003781	dimer interface [polypeptide binding]; other site
937777003782	substrate binding site [chemical binding]; other site
937777003783	metal binding site [ion binding]; metal-binding site
937777003784	The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693
937777003785	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934
937777003786	Stage II sporulation protein; Region: SpoIID; pfam08486
937777003787	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
937777003788	hydroxyglutarate oxidase; Provisional; Region: PRK11728
937777003789	FAD dependent oxidoreductase; Region: DAO; pfam01266
937777003790	threonine dehydratase; Reviewed; Region: PRK09224
937777003791	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
937777003792	tetramer interface [polypeptide binding]; other site
937777003793	pyridoxal 5'-phosphate binding site [chemical binding]; other site
937777003794	catalytic residue [active]
937777003795	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
937777003796	putative Ile/Val binding site [chemical binding]; other site
937777003797	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
937777003798	putative Ile/Val binding site [chemical binding]; other site
937777003799	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
937777003800	nudix motif; other site
937777003801	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
937777003802	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
937777003803	ATP binding site [chemical binding]; other site
937777003804	putative Mg++ binding site [ion binding]; other site
937777003805	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
937777003806	nucleotide binding region [chemical binding]; other site
937777003807	ATP-binding site [chemical binding]; other site
937777003808	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
937777003809	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
937777003810	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
937777003811	NAD(P) binding site [chemical binding]; other site
937777003812	catalytic residues [active]
937777003813	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
937777003814	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
937777003815	TPP-binding site [chemical binding]; other site
937777003816	heterodimer interface [polypeptide binding]; other site
937777003817	tetramer interface [polypeptide binding]; other site
937777003818	phosphorylation loop region [posttranslational modification]
937777003819	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
937777003820	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
937777003821	alpha subunit interface [polypeptide binding]; other site
937777003822	TPP binding site [chemical binding]; other site
937777003823	heterodimer interface [polypeptide binding]; other site
937777003824	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
937777003825	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
937777003826	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
937777003827	ligand binding site [chemical binding]; other site
937777003828	dimerization interface [polypeptide binding]; other site
937777003829	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
937777003830	metal binding site [ion binding]; metal-binding site
937777003831	active site
937777003832	I-site; other site
937777003833	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
937777003834	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
937777003835	G1 box; other site
937777003836	putative GEF interaction site [polypeptide binding]; other site
937777003837	GTP/Mg2+ binding site [chemical binding]; other site
937777003838	Switch I region; other site
937777003839	G2 box; other site
937777003840	G3 box; other site
937777003841	Switch II region; other site
937777003842	G4 box; other site
937777003843	G5 box; other site
937777003844	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
937777003845	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
937777003846	putative substrate translocation pore; other site
937777003847	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
937777003848	tartrate dehydrogenase; Provisional; Region: PRK08194
937777003849	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
937777003850	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
937777003851	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
937777003852	MOFRL family; Region: MOFRL; pfam05161
937777003853	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
937777003854	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
937777003855	Walker A/P-loop; other site
937777003856	ATP binding site [chemical binding]; other site
937777003857	Q-loop/lid; other site
937777003858	ABC transporter signature motif; other site
937777003859	Walker B; other site
937777003860	D-loop; other site
937777003861	H-loop/switch region; other site
937777003862	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
937777003863	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
937777003864	Walker A/P-loop; other site
937777003865	ATP binding site [chemical binding]; other site
937777003866	Q-loop/lid; other site
937777003867	ABC transporter signature motif; other site
937777003868	Walker B; other site
937777003869	D-loop; other site
937777003870	H-loop/switch region; other site
937777003871	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
937777003872	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
937777003873	TM-ABC transporter signature motif; other site
937777003874	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
937777003875	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
937777003876	TM-ABC transporter signature motif; other site
937777003877	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
937777003878	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
937777003879	ligand binding site [chemical binding]; other site
937777003880	Transcriptional regulators [Transcription]; Region: GntR; COG1802
937777003881	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
937777003882	DNA-binding site [nucleotide binding]; DNA binding site
937777003883	FCD domain; Region: FCD; pfam07729
937777003884	short chain dehydrogenase; Provisional; Region: PRK06123
937777003885	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
937777003886	NAD(P) binding site [chemical binding]; other site
937777003887	active site
937777003888	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
937777003889	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
937777003890	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
937777003891	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
937777003892	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
937777003893	pyridoxal 5'-phosphate binding site [chemical binding]; other site
937777003894	homodimer interface [polypeptide binding]; other site
937777003895	catalytic residue [active]
937777003896	Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842
937777003897	Domain of unknown function DUF11; Region: DUF11; cl17728
937777003898	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
937777003899	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
937777003900	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
937777003901	dimer interface [polypeptide binding]; other site
937777003902	active site
937777003903	catalytic residue [active]
937777003904	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
937777003905	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
937777003906	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
937777003907	active site
937777003908	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
937777003909	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
937777003910	NAD binding site [chemical binding]; other site
937777003911	catalytic residues [active]
937777003912	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
937777003913	active site
937777003914	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309
937777003915	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
937777003916	3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295
937777003917	N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266
937777003918	tetramer interface [polypeptide binding]; other site
937777003919	C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256
937777003920	tetramer interface [polypeptide binding]; other site
937777003921	active site
937777003922	metal binding site [ion binding]; metal-binding site
937777003923	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
937777003924	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
937777003925	putative ligand binding site [chemical binding]; other site
937777003926	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
937777003927	TM-ABC transporter signature motif; other site
937777003928	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
937777003929	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
937777003930	TM-ABC transporter signature motif; other site
937777003931	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
937777003932	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
937777003933	Walker A/P-loop; other site
937777003934	ATP binding site [chemical binding]; other site
937777003935	Q-loop/lid; other site
937777003936	ABC transporter signature motif; other site
937777003937	Walker B; other site
937777003938	D-loop; other site
937777003939	H-loop/switch region; other site
937777003940	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
937777003941	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
937777003942	Walker A/P-loop; other site
937777003943	ATP binding site [chemical binding]; other site
937777003944	Q-loop/lid; other site
937777003945	ABC transporter signature motif; other site
937777003946	Walker B; other site
937777003947	D-loop; other site
937777003948	H-loop/switch region; other site
937777003949	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
937777003950	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
937777003951	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
937777003952	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
937777003953	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
937777003954	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
937777003955	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
937777003956	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
937777003957	NADP binding site [chemical binding]; other site
937777003958	active site
937777003959	putative substrate binding site [chemical binding]; other site
937777003960	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
937777003961	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
937777003962	UDP-galactopyranose mutase; Region: GLF; pfam03275
937777003963	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
937777003964	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
937777003965	putative homodimer interface [polypeptide binding]; other site
937777003966	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
937777003967	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
937777003968	Zn2+ binding site [ion binding]; other site
937777003969	Mg2+ binding site [ion binding]; other site
937777003970	GTP-binding protein YchF; Reviewed; Region: PRK09601
937777003971	YchF GTPase; Region: YchF; cd01900
937777003972	G1 box; other site
937777003973	GTP/Mg2+ binding site [chemical binding]; other site
937777003974	Switch I region; other site
937777003975	G2 box; other site
937777003976	Switch II region; other site
937777003977	G3 box; other site
937777003978	G4 box; other site
937777003979	G5 box; other site
937777003980	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
937777003981	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231; cd11544
937777003982	homodimer interface [polypeptide binding]; other site
937777003983	active site
937777003984	metal binding site [ion binding]; metal-binding site
937777003985	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
937777003986	hypothetical protein; Reviewed; Region: PRK09588
937777003987	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
937777003988	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
937777003989	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
937777003990	catalytic residue [active]
937777003991	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
937777003992	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
937777003993	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
937777003994	Glycosyl hydrolase family 43; Region: GH43_bXyl_2; cd08991
937777003995	active site
937777003996	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
937777003997	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
937777003998	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777003999	dimer interface [polypeptide binding]; other site
937777004000	putative PBP binding loops; other site
937777004001	ABC-ATPase subunit interface; other site
937777004002	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
937777004003	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777004004	dimer interface [polypeptide binding]; other site
937777004005	conserved gate region; other site
937777004006	putative PBP binding loops; other site
937777004007	ABC-ATPase subunit interface; other site
937777004008	Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999
937777004009	putative substrate binding site [chemical binding]; other site
937777004010	active site
937777004011	Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999
937777004012	putative substrate binding site [chemical binding]; other site
937777004013	active site
937777004014	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
937777004015	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
937777004016	TPP-binding site [chemical binding]; other site
937777004017	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
937777004018	dimer interface [polypeptide binding]; other site
937777004019	PYR/PP interface [polypeptide binding]; other site
937777004020	TPP binding site [chemical binding]; other site
937777004021	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
937777004022	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
937777004023	E3 interaction surface; other site
937777004024	lipoyl attachment site [posttranslational modification]; other site
937777004025	e3 binding domain; Region: E3_binding; pfam02817
937777004026	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
937777004027	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
937777004028	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
937777004029	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
937777004030	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
937777004031	O-Antigen ligase; Region: Wzy_C; pfam04932
937777004032	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
937777004033	CoA binding domain; Region: CoA_binding; cl17356
937777004034	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
937777004035	NAD(P) binding site [chemical binding]; other site
937777004036	homodimer interface [polypeptide binding]; other site
937777004037	substrate binding site [chemical binding]; other site
937777004038	active site
937777004039	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
937777004040	UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232
937777004041	putative NAD(P) binding site [chemical binding]; other site
937777004042	active site
937777004043	putative substrate binding site [chemical binding]; other site
937777004044	Bacterial sugar transferase; Region: Bac_transf; pfam02397
937777004045	putative glycosyl transferase; Provisional; Region: PRK10307
937777004046	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
937777004047	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
937777004048	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
937777004049	active site
937777004050	homodimer interface [polypeptide binding]; other site
937777004051	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
937777004052	NAD(P) binding site [chemical binding]; other site
937777004053	active site
937777004054	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
937777004055	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
937777004056	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
937777004057	NAD(P) binding site [chemical binding]; other site
937777004058	homodimer interface [polypeptide binding]; other site
937777004059	substrate binding site [chemical binding]; other site
937777004060	active site
937777004061	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
937777004062	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
937777004063	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
937777004064	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
937777004065	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
937777004066	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
937777004067	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185
937777004068	Probable Catalytic site; other site
937777004069	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
937777004070	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
937777004071	active site
937777004072	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
937777004073	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
937777004074	GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183
937777004075	Ligand binding site; other site
937777004076	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
937777004077	active site
937777004078	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
937777004079	active site
937777004080	motif I; other site
937777004081	motif II; other site
937777004082	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
937777004083	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
937777004084	putative ADP-binding pocket [chemical binding]; other site
937777004085	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
937777004086	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
937777004087	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
937777004088	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
937777004089	active site
937777004090	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
937777004091	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
937777004092	active site
937777004093	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
937777004094	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
937777004095	Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022
937777004096	CoA binding domain; Region: CoA_binding; cl17356
937777004097	Bacterial sugar transferase; Region: Bac_transf; pfam02397
937777004098	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
937777004099	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
937777004100	Substrate binding site; other site
937777004101	futalosine nucleosidase; Region: fut_nucase; TIGR03664
937777004102	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
937777004103	active site
937777004104	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
937777004105	dimer interface [polypeptide binding]; other site
937777004106	FMN binding site [chemical binding]; other site
937777004107	NADPH bind site [chemical binding]; other site
937777004108	G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189
937777004109	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
937777004110	substrate binding site; other site
937777004111	metal-binding site
937777004112	Oligomer interface; other site
937777004113	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
937777004114	N-terminal domain interface [polypeptide binding]; other site
937777004115	sulfate 1 binding site; other site
937777004116	acetyl-CoA synthetase; Provisional; Region: PRK00174
937777004117	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
937777004118	active site
937777004119	CoA binding site [chemical binding]; other site
937777004120	acyl-activating enzyme (AAE) consensus motif; other site
937777004121	AMP binding site [chemical binding]; other site
937777004122	acetate binding site [chemical binding]; other site
937777004123	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
937777004124	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
937777004125	DNA-binding site [nucleotide binding]; DNA binding site
937777004126	UTRA domain; Region: UTRA; pfam07702
937777004127	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
937777004128	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
937777004129	2-phosphoglycerate kinase; Provisional; Region: PRK12337
937777004130	ATP cone domain; Region: ATP-cone; pfam03477
937777004131	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
937777004132	Walker A motif; other site
937777004133	ATP binding site [chemical binding]; other site
937777004134	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
937777004135	TrkA-N domain; Region: TrkA_N; pfam02254
937777004136	TrkA-C domain; Region: TrkA_C; pfam02080
937777004137	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
937777004138	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
937777004139	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
937777004140	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
937777004141	S-adenosylmethionine binding site [chemical binding]; other site
937777004142	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
937777004143	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
937777004144	nucleotide binding site [chemical binding]; other site
937777004145	putative RNA polymerase sigma E protein; Provisional; Region: PRK13919
937777004146	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
937777004147	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
937777004148	DNA binding residues [nucleotide binding]
937777004149	putative anti-sigmaE protein; Provisional; Region: PRK13920
937777004150	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
937777004151	23S rRNA binding site [nucleotide binding]; other site
937777004152	L21 binding site [polypeptide binding]; other site
937777004153	L13 binding site [polypeptide binding]; other site
937777004154	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
937777004155	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
937777004156	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
937777004157	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
937777004158	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
937777004159	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
937777004160	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
937777004161	active site
937777004162	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
937777004163	nudix motif; other site
937777004164	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
937777004165	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494
937777004166	recombination protein RecR; Reviewed; Region: recR; PRK00076
937777004167	RecR protein; Region: RecR; pfam02132
937777004168	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
937777004169	putative active site [active]
937777004170	putative metal-binding site [ion binding]; other site
937777004171	tetramer interface [polypeptide binding]; other site
937777004172	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
937777004173	Roadblock/LC7 domain; Region: Robl_LC7; smart00960
937777004174	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
937777004175	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
937777004176	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
937777004177	Walker A/P-loop; other site
937777004178	ATP binding site [chemical binding]; other site
937777004179	Q-loop/lid; other site
937777004180	ABC transporter signature motif; other site
937777004181	Walker B; other site
937777004182	D-loop; other site
937777004183	H-loop/switch region; other site
937777004184	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
937777004185	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
937777004186	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
937777004187	Walker A/P-loop; other site
937777004188	ATP binding site [chemical binding]; other site
937777004189	Q-loop/lid; other site
937777004190	ABC transporter signature motif; other site
937777004191	Walker B; other site
937777004192	D-loop; other site
937777004193	H-loop/switch region; other site
937777004194	elongation factor Tu; Reviewed; Region: PRK00049
937777004195	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
937777004196	G1 box; other site
937777004197	GEF interaction site [polypeptide binding]; other site
937777004198	GTP/Mg2+ binding site [chemical binding]; other site
937777004199	Switch I region; other site
937777004200	G2 box; other site
937777004201	G3 box; other site
937777004202	Switch II region; other site
937777004203	G4 box; other site
937777004204	G5 box; other site
937777004205	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
937777004206	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
937777004207	Antibiotic Binding Site [chemical binding]; other site
937777004208	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
937777004209	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
937777004210	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
937777004211	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
937777004212	putative homodimer interface [polypeptide binding]; other site
937777004213	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
937777004214	heterodimer interface [polypeptide binding]; other site
937777004215	homodimer interface [polypeptide binding]; other site
937777004216	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
937777004217	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
937777004218	23S rRNA interface [nucleotide binding]; other site
937777004219	L7/L12 interface [polypeptide binding]; other site
937777004220	putative thiostrepton binding site; other site
937777004221	L25 interface [polypeptide binding]; other site
937777004222	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
937777004223	mRNA/rRNA interface [nucleotide binding]; other site
937777004224	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
937777004225	23S rRNA interface [nucleotide binding]; other site
937777004226	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
937777004227	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
937777004228	peripheral dimer interface [polypeptide binding]; other site
937777004229	core dimer interface [polypeptide binding]; other site
937777004230	L10 interface [polypeptide binding]; other site
937777004231	L11 interface [polypeptide binding]; other site
937777004232	putative EF-Tu interaction site [polypeptide binding]; other site
937777004233	putative EF-G interaction site [polypeptide binding]; other site
937777004234	Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700
937777004235	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
937777004236	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
937777004237	TPR motif; other site
937777004238	binding surface
937777004239	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
937777004240	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
937777004241	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
937777004242	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
937777004243	RPB10 interaction site [polypeptide binding]; other site
937777004244	RPB1 interaction site [polypeptide binding]; other site
937777004245	RPB11 interaction site [polypeptide binding]; other site
937777004246	RPB3 interaction site [polypeptide binding]; other site
937777004247	RPB12 interaction site [polypeptide binding]; other site
937777004248	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
937777004249	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
937777004250	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
937777004251	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
937777004252	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
937777004253	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
937777004254	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
937777004255	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
937777004256	DNA binding site [nucleotide binding]
937777004257	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
937777004258	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
937777004259	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
937777004260	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
937777004261	active site
937777004262	dimer interface [polypeptide binding]; other site
937777004263	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
937777004264	L-lactate permease; Region: Lactate_perm; cl00701
937777004265	L-lactate permease; Region: Lactate_perm; cl00701
937777004266	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
937777004267	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
937777004268	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
937777004269	Isochorismatase family; Region: Isochorismatase; pfam00857
937777004270	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
937777004271	catalytic triad [active]
937777004272	conserved cis-peptide bond; other site
937777004273	Uncharacterized conserved protein [Function unknown]; Region: COG0398
937777004274	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
937777004275	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
937777004276	MoxR-like ATPases [General function prediction only]; Region: COG0714
937777004277	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
937777004278	Walker A motif; other site
937777004279	ATP binding site [chemical binding]; other site
937777004280	Walker B motif; other site
937777004281	arginine finger; other site
937777004282	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
937777004283	Protein of unknown function DUF58; Region: DUF58; pfam01882
937777004284	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
937777004285	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
937777004286	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
937777004287	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
937777004288	MG2 domain; Region: A2M_N; pfam01835
937777004289	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
937777004290	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
937777004291	glutaminase active site [active]
937777004292	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
937777004293	dimer interface [polypeptide binding]; other site
937777004294	active site
937777004295	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
937777004296	dimer interface [polypeptide binding]; other site
937777004297	active site
937777004298	hypothetical protein; Provisional; Region: PRK12705
937777004299	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
937777004300	Zn2+ binding site [ion binding]; other site
937777004301	Mg2+ binding site [ion binding]; other site
937777004302	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
937777004303	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
937777004304	Active site serine [active]
937777004305	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
937777004306	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
937777004307	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777004308	dimer interface [polypeptide binding]; other site
937777004309	conserved gate region; other site
937777004310	putative PBP binding loops; other site
937777004311	ABC-ATPase subunit interface; other site
937777004312	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
937777004313	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777004314	dimer interface [polypeptide binding]; other site
937777004315	conserved gate region; other site
937777004316	putative PBP binding loops; other site
937777004317	ABC-ATPase subunit interface; other site
937777004318	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
937777004319	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
937777004320	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
937777004321	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
937777004322	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
937777004323	probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648
937777004324	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
937777004325	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
937777004326	dimer interface [polypeptide binding]; other site
937777004327	catalytic triad [active]
937777004328	MarR family; Region: MarR_2; cl17246
937777004329	Predicted membrane protein [Function unknown]; Region: COG2860
937777004330	UPF0126 domain; Region: UPF0126; pfam03458
937777004331	UPF0126 domain; Region: UPF0126; pfam03458
937777004332	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
937777004333	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
937777004334	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
937777004335	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
937777004336	active site
937777004337	dimer interfaces [polypeptide binding]; other site
937777004338	catalytic residues [active]
937777004339	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
937777004340	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
937777004341	Coenzyme A binding pocket [chemical binding]; other site
937777004342	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14963
937777004343	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
937777004344	Walker A motif; other site
937777004345	ATP binding site [chemical binding]; other site
937777004346	Walker B motif; other site
937777004347	arginine finger; other site
937777004348	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
937777004349	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
937777004350	inhibitor-cofactor binding pocket; inhibition site
937777004351	pyridoxal 5'-phosphate binding site [chemical binding]; other site
937777004352	catalytic residue [active]
937777004353	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
937777004354	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
937777004355	PEGA domain; Region: PEGA; pfam08308
937777004356	PEGA domain; Region: PEGA; pfam08308
937777004357	Phosphotransferase enzyme family; Region: APH; pfam01636
937777004358	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
937777004359	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
937777004360	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cl10030
937777004361	homotrimer interaction site [polypeptide binding]; other site
937777004362	zinc binding site [ion binding]; other site
937777004363	CDP-binding sites; other site
937777004364	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
937777004365	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
937777004366	Walker A/P-loop; other site
937777004367	ATP binding site [chemical binding]; other site
937777004368	Q-loop/lid; other site
937777004369	ABC transporter signature motif; other site
937777004370	Walker B; other site
937777004371	D-loop; other site
937777004372	H-loop/switch region; other site
937777004373	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
937777004374	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
937777004375	Zn2+ binding site [ion binding]; other site
937777004376	Mg2+ binding site [ion binding]; other site
937777004377	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
937777004378	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
937777004379	homodimer interface [polypeptide binding]; other site
937777004380	substrate-cofactor binding pocket; other site
937777004381	pyridoxal 5'-phosphate binding site [chemical binding]; other site
937777004382	catalytic residue [active]
937777004383	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
937777004384	Dynamin family; Region: Dynamin_N; pfam00350
937777004385	G1 box; other site
937777004386	GTP/Mg2+ binding site [chemical binding]; other site
937777004387	G2 box; other site
937777004388	Switch I region; other site
937777004389	G3 box; other site
937777004390	Switch II region; other site
937777004391	G4 box; other site
937777004392	G5 box; other site
937777004393	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
937777004394	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
937777004395	motif 1; other site
937777004396	active site
937777004397	motif 2; other site
937777004398	motif 3; other site
937777004399	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
937777004400	Predicted transporter component [General function prediction only]; Region: COG2391
937777004401	Sulphur transport; Region: Sulf_transp; pfam04143
937777004402	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
937777004403	Predicted transporter component [General function prediction only]; Region: COG2391
937777004404	Sulphur transport; Region: Sulf_transp; pfam04143
937777004405	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
937777004406	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
937777004407	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
937777004408	active site residue [active]
937777004409	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
937777004410	active site residue [active]
937777004411	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
937777004412	putative homodimer interface [polypeptide binding]; other site
937777004413	putative homotetramer interface [polypeptide binding]; other site
937777004414	putative allosteric switch controlling residues; other site
937777004415	putative metal binding site [ion binding]; other site
937777004416	putative homodimer-homodimer interface [polypeptide binding]; other site
937777004417	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
937777004418	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
937777004419	motif II; other site
937777004420	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
937777004421	nudix motif; other site
937777004422	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
937777004423	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
937777004424	nudix motif; other site
937777004425	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
937777004426	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
937777004427	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
937777004428	Predicted membrane protein [Function unknown]; Region: COG4325
937777004429	GAF domain; Region: GAF_3; pfam13492
937777004430	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777004431	PAS fold; Region: PAS_3; pfam08447
937777004432	putative active site [active]
937777004433	heme pocket [chemical binding]; other site
937777004434	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777004435	dimer interface [polypeptide binding]; other site
937777004436	phosphorylation site [posttranslational modification]
937777004437	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777004438	ATP binding site [chemical binding]; other site
937777004439	Mg2+ binding site [ion binding]; other site
937777004440	G-X-G motif; other site
937777004441	replicative DNA helicase; Region: DnaB; TIGR00665
937777004442	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
937777004443	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
937777004444	Walker A motif; other site
937777004445	ATP binding site [chemical binding]; other site
937777004446	Walker B motif; other site
937777004447	DNA binding loops [nucleotide binding]
937777004448	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
937777004449	nudix motif; other site
937777004450	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
937777004451	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
937777004452	NAD(P) binding site [chemical binding]; other site
937777004453	active site
937777004454	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
937777004455	ATP cone domain; Region: ATP-cone; pfam03477
937777004456	ornithine cyclodeaminase; Validated; Region: PRK06141
937777004457	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
937777004458	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
937777004459	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
937777004460	TM-ABC transporter signature motif; other site
937777004461	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
937777004462	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
937777004463	TM-ABC transporter signature motif; other site
937777004464	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
937777004465	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
937777004466	putative ligand binding site [chemical binding]; other site
937777004467	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
937777004468	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
937777004469	Walker A/P-loop; other site
937777004470	ATP binding site [chemical binding]; other site
937777004471	Q-loop/lid; other site
937777004472	ABC transporter signature motif; other site
937777004473	Walker B; other site
937777004474	D-loop; other site
937777004475	H-loop/switch region; other site
937777004476	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
937777004477	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
937777004478	Walker A/P-loop; other site
937777004479	ATP binding site [chemical binding]; other site
937777004480	Q-loop/lid; other site
937777004481	ABC transporter signature motif; other site
937777004482	Walker B; other site
937777004483	D-loop; other site
937777004484	H-loop/switch region; other site
937777004485	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
937777004486	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
937777004487	putative RNA binding site [nucleotide binding]; other site
937777004488	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
937777004489	S-adenosylmethionine binding site [chemical binding]; other site
937777004490	Protein of unknown function (DUF3248); Region: DUF3248; pfam11609
937777004491	Protein of unknown function (DUF3809); Region: DUF3809; pfam12723
937777004492	Transcriptional regulators [Transcription]; Region: PurR; COG1609
937777004493	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
937777004494	DNA binding site [nucleotide binding]
937777004495	domain linker motif; other site
937777004496	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_9; cd06290
937777004497	putative dimerization interface [polypeptide binding]; other site
937777004498	putative ligand binding site [chemical binding]; other site
937777004499	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
937777004500	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
937777004501	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777004502	dimer interface [polypeptide binding]; other site
937777004503	conserved gate region; other site
937777004504	putative PBP binding loops; other site
937777004505	ABC-ATPase subunit interface; other site
937777004506	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
937777004507	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777004508	dimer interface [polypeptide binding]; other site
937777004509	conserved gate region; other site
937777004510	putative PBP binding loops; other site
937777004511	ABC-ATPase subunit interface; other site
937777004512	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
937777004513	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
937777004514	beta-galactosidase; Region: BGL; TIGR03356
937777004515	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
937777004516	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
937777004517	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
937777004518	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
937777004519	metal-dependent hydrolase; Provisional; Region: PRK00685
937777004520	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
937777004521	Catalytic domain of Protein Kinases; Region: PKc; cd00180
937777004522	active site
937777004523	ATP binding site [chemical binding]; other site
937777004524	substrate binding site [chemical binding]; other site
937777004525	activation loop (A-loop); other site
937777004526	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
937777004527	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
937777004528	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
937777004529	motif II; other site
937777004530	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
937777004531	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
937777004532	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
937777004533	MgtE intracellular N domain; Region: MgtE_N; smart00924
937777004534	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
937777004535	Divalent cation transporter; Region: MgtE; pfam01769
937777004536	monovalent cation/proton antiporter, MnhG/PhaG subunit; Region: CPA3_mnhG_phaG; TIGR01300
937777004537	Multisubunit Na+/H+ antiporter, MnhF subunit [Inorganic ion transport and metabolism]; Region: MnhF; COG2212
937777004538	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651
937777004539	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
937777004540	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
937777004541	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
937777004542	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
937777004543	monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645
937777004544	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
937777004545	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
937777004546	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
937777004547	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
937777004548	Ligand Binding Site [chemical binding]; other site
937777004549	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
937777004550	Ligand Binding Site [chemical binding]; other site
937777004551	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
937777004552	DNA binding residues [nucleotide binding]
937777004553	PIN domain; Region: PIN_3; cl17397
937777004554	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
937777004555	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
937777004556	polyphosphate kinase; Provisional; Region: PRK05443
937777004557	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
937777004558	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
937777004559	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
937777004560	putative domain interface [polypeptide binding]; other site
937777004561	putative active site [active]
937777004562	catalytic site [active]
937777004563	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
937777004564	putative domain interface [polypeptide binding]; other site
937777004565	putative active site [active]
937777004566	catalytic site [active]
937777004567	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
937777004568	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
937777004569	dimer interface [polypeptide binding]; other site
937777004570	active site
937777004571	acyl carrier protein; Provisional; Region: acpP; PRK00982
937777004572	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
937777004573	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
937777004574	NAD(P) binding site [chemical binding]; other site
937777004575	homotetramer interface [polypeptide binding]; other site
937777004576	homodimer interface [polypeptide binding]; other site
937777004577	active site
937777004578	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
937777004579	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
937777004580	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
937777004581	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
937777004582	dimer interface [polypeptide binding]; other site
937777004583	active site
937777004584	CoA binding pocket [chemical binding]; other site
937777004585	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
937777004586	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855
937777004587	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
937777004588	trimer interface [polypeptide binding]; other site
937777004589	dimer interface [polypeptide binding]; other site
937777004590	putative active site [active]
937777004591	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
937777004592	agmatinase; Region: agmatinase; TIGR01230
937777004593	Arginase family; Region: Arginase; cd09989
937777004594	active site
937777004595	Mn binding site [ion binding]; other site
937777004596	oligomer interface [polypeptide binding]; other site
937777004597	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
937777004598	sequence-specific DNA binding site [nucleotide binding]; other site
937777004599	salt bridge; other site
937777004600	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
937777004601	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
937777004602	active site
937777004603	Zn binding site [ion binding]; other site
937777004604	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
937777004605	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
937777004606	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
937777004607	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
937777004608	DHH family; Region: DHH; pfam01368
937777004609	DHHA2 domain; Region: DHHA2; pfam02833
937777004610	S-layer homology domain; Region: SLH; pfam00395
937777004611	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
937777004612	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
937777004613	Protease prsW family; Region: PrsW-protease; cl15823
937777004614	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280
937777004615	active site
937777004616	putative DNA-binding cleft [nucleotide binding]; other site
937777004617	dimer interface [polypeptide binding]; other site
937777004618	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
937777004619	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777004620	dimer interface [polypeptide binding]; other site
937777004621	conserved gate region; other site
937777004622	putative PBP binding loops; other site
937777004623	ABC-ATPase subunit interface; other site
937777004624	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
937777004625	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777004626	dimer interface [polypeptide binding]; other site
937777004627	conserved gate region; other site
937777004628	putative PBP binding loops; other site
937777004629	ABC-ATPase subunit interface; other site
937777004630	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
937777004631	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
937777004632	peptide binding site [polypeptide binding]; other site
937777004633	dimer interface [polypeptide binding]; other site
937777004634	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
937777004635	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
937777004636	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
937777004637	active site
937777004638	cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04135
937777004639	cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200
937777004640	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
937777004641	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
937777004642	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
937777004643	HRDC domain; Region: HRDC; pfam00570
937777004644	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
937777004645	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
937777004646	catalytic residue [active]
937777004647	putative FPP diphosphate  binding site; other site
937777004648	putative FPP binding hydrophobic cleft; other site
937777004649	dimer interface [polypeptide binding]; other site
937777004650	putative IPP diphosphate binding site; other site
937777004651	A/G-specific adenine glycosylase; Region: mutY; TIGR01084
937777004652	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
937777004653	minor groove reading motif; other site
937777004654	helix-hairpin-helix signature motif; other site
937777004655	substrate binding pocket [chemical binding]; other site
937777004656	active site
937777004657	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
937777004658	Predicted integral membrane protein (DUF2270); Region: DUF2270; cl02337
937777004659	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
937777004660	NAD-dependent deacetylase; Provisional; Region: PRK00481
937777004661	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
937777004662	NAD+ binding site [chemical binding]; other site
937777004663	substrate binding site [chemical binding]; other site
937777004664	Zn binding site [ion binding]; other site
937777004665	Protein of unknown function (DUF3105); Region: DUF3105; pfam11303
937777004666	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
937777004667	Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867
937777004668	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
937777004669	metal ion-dependent adhesion site (MIDAS); other site
937777004670	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
937777004671	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
937777004672	metal binding site [ion binding]; metal-binding site
937777004673	active site
937777004674	I-site; other site
937777004675	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
937777004676	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777004677	active site
937777004678	phosphorylation site [posttranslational modification]
937777004679	intermolecular recognition site; other site
937777004680	dimerization interface [polypeptide binding]; other site
937777004681	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
937777004682	DNA binding site [nucleotide binding]
937777004683	AMIN domain; Region: AMIN; pfam11741
937777004684	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
937777004685	Roadblock/LC7 domain; Region: Robl_LC7; pfam03259
937777004686	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
937777004687	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
937777004688	G1 box; other site
937777004689	GTP/Mg2+ binding site [chemical binding]; other site
937777004690	G2 box; other site
937777004691	Switch I region; other site
937777004692	G3 box; other site
937777004693	Switch II region; other site
937777004694	G4 box; other site
937777004695	G5 box; other site
937777004696	Uncharacterized conserved protein [Function unknown]; Region: COG3603
937777004697	Family description; Region: ACT_7; pfam13840
937777004698	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
937777004699	PhoU domain; Region: PhoU; pfam01895
937777004700	PhoU domain; Region: PhoU; pfam01895
937777004701	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
937777004702	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
937777004703	Walker A/P-loop; other site
937777004704	ATP binding site [chemical binding]; other site
937777004705	Q-loop/lid; other site
937777004706	ABC transporter signature motif; other site
937777004707	Walker B; other site
937777004708	D-loop; other site
937777004709	H-loop/switch region; other site
937777004710	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
937777004711	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777004712	dimer interface [polypeptide binding]; other site
937777004713	conserved gate region; other site
937777004714	putative PBP binding loops; other site
937777004715	ABC-ATPase subunit interface; other site
937777004716	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
937777004717	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777004718	dimer interface [polypeptide binding]; other site
937777004719	conserved gate region; other site
937777004720	putative PBP binding loops; other site
937777004721	ABC-ATPase subunit interface; other site
937777004722	PBP superfamily domain; Region: PBP_like_2; cl17296
937777004723	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
937777004724	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
937777004725	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
937777004726	Family description; Region: UvrD_C_2; pfam13538
937777004727	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
937777004728	Protein of unknown function (DUF4127); Region: DUF4127; pfam13552
937777004729	Protein of unknown function (DUF4127); Region: DUF4127; pfam13552
937777004730	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
937777004731	Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
937777004732	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
937777004733	active site
937777004734	metal binding site [ion binding]; metal-binding site
937777004735	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
937777004736	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
937777004737	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
937777004738	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
937777004739	CutA1 divalent ion tolerance protein; Region: CutA1; pfam03091
937777004740	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
937777004741	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
937777004742	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
937777004743	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
937777004744	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
937777004745	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
937777004746	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
937777004747	E3 interaction surface; other site
937777004748	lipoyl attachment site [posttranslational modification]; other site
937777004749	e3 binding domain; Region: E3_binding; pfam02817
937777004750	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
937777004751	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
937777004752	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
937777004753	alpha subunit interface [polypeptide binding]; other site
937777004754	TPP binding site [chemical binding]; other site
937777004755	heterodimer interface [polypeptide binding]; other site
937777004756	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
937777004757	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
937777004758	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
937777004759	TPP-binding site [chemical binding]; other site
937777004760	tetramer interface [polypeptide binding]; other site
937777004761	heterodimer interface [polypeptide binding]; other site
937777004762	phosphorylation loop region [posttranslational modification]
937777004763	Predicted amidohydrolase [General function prediction only]; Region: COG0388
937777004764	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
937777004765	putative active site [active]
937777004766	catalytic triad [active]
937777004767	putative dimer interface [polypeptide binding]; other site
937777004768	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
937777004769	Coenzyme A binding pocket [chemical binding]; other site
937777004770	conserved hypothetical protein, steroid delta-isomerase-related; Region: TIGR02096
937777004771	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
937777004772	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557
937777004773	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
937777004774	putative active site [active]
937777004775	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
937777004776	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
937777004777	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777004778	dimer interface [polypeptide binding]; other site
937777004779	conserved gate region; other site
937777004780	putative PBP binding loops; other site
937777004781	ABC-ATPase subunit interface; other site
937777004782	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
937777004783	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777004784	dimer interface [polypeptide binding]; other site
937777004785	conserved gate region; other site
937777004786	putative PBP binding loops; other site
937777004787	ABC-ATPase subunit interface; other site
937777004788	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
937777004789	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
937777004790	hypothetical protein; Provisional; Region: PRK02395
937777004791	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
937777004792	putative active site [active]
937777004793	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
937777004794	putative active site [active]
937777004795	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
937777004796	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
937777004797	catalytic core [active]
937777004798	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
937777004799	Phosphotransferase enzyme family; Region: APH; pfam01636
937777004800	putative active site [active]
937777004801	putative substrate binding site [chemical binding]; other site
937777004802	ATP binding site [chemical binding]; other site
937777004803	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
937777004804	classical (c) SDRs; Region: SDR_c; cd05233
937777004805	NAD(P) binding site [chemical binding]; other site
937777004806	active site
937777004807	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
937777004808	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
937777004809	FAD binding site [chemical binding]; other site
937777004810	substrate binding site [chemical binding]; other site
937777004811	catalytic base [active]
937777004812	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
937777004813	putative active site [active]
937777004814	putative catalytic site [active]
937777004815	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
937777004816	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
937777004817	NAD(P) binding site [chemical binding]; other site
937777004818	active site
937777004819	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
937777004820	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
937777004821	TAP-like protein; Region: Abhydrolase_4; pfam08386
937777004822	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
937777004823	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
937777004824	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
937777004825	active site
937777004826	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
937777004827	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
937777004828	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
937777004829	dimer interface [polypeptide binding]; other site
937777004830	active site
937777004831	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
937777004832	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
937777004833	substrate binding site [chemical binding]; other site
937777004834	oxyanion hole (OAH) forming residues; other site
937777004835	trimer interface [polypeptide binding]; other site
937777004836	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
937777004837	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
937777004838	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
937777004839	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
937777004840	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
937777004841	Walker A/P-loop; other site
937777004842	ATP binding site [chemical binding]; other site
937777004843	Q-loop/lid; other site
937777004844	ABC transporter signature motif; other site
937777004845	Walker B; other site
937777004846	D-loop; other site
937777004847	H-loop/switch region; other site
937777004848	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
937777004849	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
937777004850	Walker A/P-loop; other site
937777004851	ATP binding site [chemical binding]; other site
937777004852	Q-loop/lid; other site
937777004853	ABC transporter signature motif; other site
937777004854	Walker B; other site
937777004855	D-loop; other site
937777004856	H-loop/switch region; other site
937777004857	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
937777004858	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
937777004859	TM-ABC transporter signature motif; other site
937777004860	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
937777004861	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
937777004862	TM-ABC transporter signature motif; other site
937777004863	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336
937777004864	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
937777004865	putative ligand binding site [chemical binding]; other site
937777004866	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
937777004867	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
937777004868	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
937777004869	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
937777004870	active site
937777004871	Protein of unknown function (DUF1572); Region: DUF1572; pfam07609
937777004872	Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042
937777004873	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
937777004874	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
937777004875	metal binding site [ion binding]; metal-binding site
937777004876	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
937777004877	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
937777004878	metal binding site [ion binding]; metal-binding site
937777004879	active site
937777004880	I-site; other site
937777004881	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
937777004882	nucleoside/Zn binding site; other site
937777004883	dimer interface [polypeptide binding]; other site
937777004884	catalytic motif [active]
937777004885	menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701
937777004886	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
937777004887	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
937777004888	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
937777004889	active site
937777004890	MarC family integral membrane protein; Region: MarC; pfam01914
937777004891	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
937777004892	Protein of unknown function (DUF3583); Region: DUF3583; pfam12126
937777004893	Predicted membrane protein [Function unknown]; Region: COG2323
937777004894	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
937777004895	intracellular protease, PfpI family; Region: PfpI; TIGR01382
937777004896	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
937777004897	proposed catalytic triad [active]
937777004898	conserved cys residue [active]
937777004899	Transcriptional regulators [Transcription]; Region: PurR; COG1609
937777004900	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
937777004901	DNA binding site [nucleotide binding]
937777004902	domain linker motif; other site
937777004903	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
937777004904	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
937777004905	D-xylulose kinase; Region: XylB; TIGR01312
937777004906	N- and C-terminal domain interface [polypeptide binding]; other site
937777004907	active site
937777004908	MgATP binding site [chemical binding]; other site
937777004909	catalytic site [active]
937777004910	metal binding site [ion binding]; metal-binding site
937777004911	xylulose binding site [chemical binding]; other site
937777004912	homodimer interface [polypeptide binding]; other site
937777004913	xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631
937777004914	xylose isomerase; Provisional; Region: PRK12677
937777004915	MarR family; Region: MarR_2; pfam12802
937777004916	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
937777004917	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
937777004918	nucleotide binding site [chemical binding]; other site
937777004919	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
937777004920	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
937777004921	NAD(P) binding site [chemical binding]; other site
937777004922	Protein of unknown function (DUF421); Region: DUF421; cl00990
937777004923	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
937777004924	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
937777004925	NAD binding site [chemical binding]; other site
937777004926	catalytic Zn binding site [ion binding]; other site
937777004927	structural Zn binding site [ion binding]; other site
937777004928	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
937777004929	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
937777004930	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
937777004931	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
937777004932	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
937777004933	hydroxyglutarate oxidase; Provisional; Region: PRK11728
937777004934	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
937777004935	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
937777004936	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
937777004937	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
937777004938	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
937777004939	DNA binding residues [nucleotide binding]
937777004940	Arginine repressor [Transcription]; Region: ArgR; COG1438
937777004941	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
937777004942	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
937777004943	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
937777004944	Flavoprotein; Region: Flavoprotein; pfam02441
937777004945	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
937777004946	DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758
937777004947	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
937777004948	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
937777004949	Walker A/P-loop; other site
937777004950	ATP binding site [chemical binding]; other site
937777004951	Q-loop/lid; other site
937777004952	ABC transporter signature motif; other site
937777004953	Walker B; other site
937777004954	D-loop; other site
937777004955	H-loop/switch region; other site
937777004956	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
937777004957	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
937777004958	Cl binding site [ion binding]; other site
937777004959	oligomer interface [polypeptide binding]; other site
937777004960	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
937777004961	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
937777004962	structural tetrad; other site
937777004963	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
937777004964	Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like2; cd08198
937777004965	active site
937777004966	metal binding site [ion binding]; metal-binding site
937777004967	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
937777004968	active site
937777004969	TatD related DNase; Region: TatD_DNase; pfam01026
937777004970	UbiA prenyltransferase family; Region: UbiA; pfam01040
937777004971	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
937777004972	Uncharacterized conserved protein [Function unknown]; Region: COG3379
937777004973	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
937777004974	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
937777004975	active site
937777004976	catalytic site [active]
937777004977	substrate binding site [chemical binding]; other site
937777004978	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
937777004979	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
937777004980	ligand binding site [chemical binding]; other site
937777004981	active site
937777004982	UGI interface [polypeptide binding]; other site
937777004983	catalytic site [active]
937777004984	excinuclease ABC subunit B; Provisional; Region: PRK05298
937777004985	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
937777004986	ATP binding site [chemical binding]; other site
937777004987	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
937777004988	nucleotide binding region [chemical binding]; other site
937777004989	ATP-binding site [chemical binding]; other site
937777004990	Ultra-violet resistance protein B; Region: UvrB; pfam12344
937777004991	UvrB/uvrC motif; Region: UVR; pfam02151
937777004992	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
937777004993	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
937777004994	active site
937777004995	metal binding site [ion binding]; metal-binding site
937777004996	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
937777004997	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
937777004998	putative oligomer interface [polypeptide binding]; other site
937777004999	putative active site [active]
937777005000	metal binding site [ion binding]; metal-binding site
937777005001	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
937777005002	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
937777005003	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777005004	active site
937777005005	phosphorylation site [posttranslational modification]
937777005006	intermolecular recognition site; other site
937777005007	dimerization interface [polypeptide binding]; other site
937777005008	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
937777005009	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
937777005010	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777005011	ATP binding site [chemical binding]; other site
937777005012	Mg2+ binding site [ion binding]; other site
937777005013	G-X-G motif; other site
937777005014	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
937777005015	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
937777005016	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
937777005017	PAS fold; Region: PAS_4; pfam08448
937777005018	GAF domain; Region: GAF_2; pfam13185
937777005019	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
937777005020	GAF domain; Region: GAF_3; pfam13492
937777005021	GAF domain; Region: GAF; pfam01590
937777005022	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777005023	dimer interface [polypeptide binding]; other site
937777005024	phosphorylation site [posttranslational modification]
937777005025	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777005026	ATP binding site [chemical binding]; other site
937777005027	G-X-G motif; other site
937777005028	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
937777005029	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
937777005030	PA/protease or protease-like domain interface [polypeptide binding]; other site
937777005031	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
937777005032	Peptidase family M28; Region: Peptidase_M28; pfam04389
937777005033	metal binding site [ion binding]; metal-binding site
937777005034	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
937777005035	proposed catalytic triad [active]
937777005036	active site nucleophile [active]
937777005037	Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and  L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635
937777005038	active site
937777005039	dimer interface [polypeptide binding]; other site
937777005040	catalytic nucleophile [active]
937777005041	cyanophycin synthetase; Provisional; Region: PRK14016
937777005042	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
937777005043	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
937777005044	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
937777005045	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
937777005046	putative active site [active]
937777005047	catalytic triad [active]
937777005048	PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818
937777005049	PA/protease or protease-like domain interface [polypeptide binding]; other site
937777005050	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
937777005051	catalytic residues [active]
937777005052	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
937777005053	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
937777005054	NADP binding site [chemical binding]; other site
937777005055	dimer interface [polypeptide binding]; other site
937777005056	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
937777005057	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
937777005058	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
937777005059	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
937777005060	metal binding site [ion binding]; metal-binding site
937777005061	active site
937777005062	I-site; other site
937777005063	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
937777005064	Cytochrome P450; Region: p450; pfam00067
937777005065	Carbohydrate binding domain (family 17/28); Region: CBM_17_28; pfam03424
937777005066	Carbohydrate binding domain (family 17/28); Region: CBM_17_28; pfam03424
937777005067	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
937777005068	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
937777005069	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
937777005070	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
937777005071	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777005072	dimer interface [polypeptide binding]; other site
937777005073	conserved gate region; other site
937777005074	putative PBP binding loops; other site
937777005075	ABC-ATPase subunit interface; other site
937777005076	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
937777005077	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777005078	dimer interface [polypeptide binding]; other site
937777005079	conserved gate region; other site
937777005080	putative PBP binding loops; other site
937777005081	ABC-ATPase subunit interface; other site
937777005082	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
937777005083	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511
937777005084	Transcriptional regulators [Transcription]; Region: FadR; COG2186
937777005085	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
937777005086	DNA-binding site [nucleotide binding]; DNA binding site
937777005087	FCD domain; Region: FCD; pfam07729
937777005088	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
937777005089	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
937777005090	FMN binding site [chemical binding]; other site
937777005091	active site
937777005092	substrate binding site [chemical binding]; other site
937777005093	catalytic residue [active]
937777005094	Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447
937777005095	active site
937777005096	catalytic residue [active]
937777005097	AAA domain; Region: AAA_33; pfam13671
937777005098	tRNA ligase kinase domain; Region: tRNA_lig_kinase; pfam08303
937777005099	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
937777005100	classical (c) SDRs; Region: SDR_c; cd05233
937777005101	NAD(P) binding site [chemical binding]; other site
937777005102	active site
937777005103	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
937777005104	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
937777005105	active site
937777005106	catalytic tetrad [active]
937777005107	Cupin domain; Region: Cupin_2; pfam07883
937777005108	Cupin domain; Region: Cupin_2; pfam07883
937777005109	Hypothetical protein TTHB210, a sigma(E)-regulated gene product found in Thermus thermophilus, and similar proteins; Region: TTHB210-like; cd11669
937777005110	oligomer interface [polypeptide binding]; other site
937777005111	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
937777005112	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
937777005113	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
937777005114	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
937777005115	PYR/PP interface [polypeptide binding]; other site
937777005116	dimer interface [polypeptide binding]; other site
937777005117	TPP binding site [chemical binding]; other site
937777005118	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
937777005119	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
937777005120	TPP-binding site [chemical binding]; other site
937777005121	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
937777005122	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
937777005123	substrate binding site [chemical binding]; other site
937777005124	ATP binding site [chemical binding]; other site
937777005125	KduI/IolB family; Region: KduI; pfam04962
937777005126	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
937777005127	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777005128	PAS domain; Region: PAS_9; pfam13426
937777005129	putative active site [active]
937777005130	heme pocket [chemical binding]; other site
937777005131	GAF domain; Region: GAF; pfam01590
937777005132	GAF domain; Region: GAF_2; pfam13185
937777005133	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
937777005134	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
937777005135	PAS domain S-box; Region: sensory_box; TIGR00229
937777005136	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777005137	putative active site [active]
937777005138	heme pocket [chemical binding]; other site
937777005139	PAS domain S-box; Region: sensory_box; TIGR00229
937777005140	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777005141	putative active site [active]
937777005142	heme pocket [chemical binding]; other site
937777005143	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
937777005144	GAF domain; Region: GAF; pfam01590
937777005145	GAF domain; Region: GAF_3; pfam13492
937777005146	GAF domain; Region: GAF_2; pfam13185
937777005147	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
937777005148	GAF domain; Region: GAF; pfam01590
937777005149	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777005150	dimer interface [polypeptide binding]; other site
937777005151	phosphorylation site [posttranslational modification]
937777005152	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777005153	ATP binding site [chemical binding]; other site
937777005154	Mg2+ binding site [ion binding]; other site
937777005155	G-X-G motif; other site
937777005156	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
937777005157	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777005158	active site
937777005159	phosphorylation site [posttranslational modification]
937777005160	intermolecular recognition site; other site
937777005161	dimerization interface [polypeptide binding]; other site
937777005162	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
937777005163	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
937777005164	active site
937777005165	catalytic site [active]
937777005166	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
937777005167	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
937777005168	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
937777005169	YibE/F-like protein; Region: YibE_F; pfam07907
937777005170	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
937777005171	Chromate transporter; Region: Chromate_transp; pfam02417
937777005172	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
937777005173	classical (c) SDRs; Region: SDR_c; cd05233
937777005174	NAD(P) binding site [chemical binding]; other site
937777005175	active site
937777005176	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
937777005177	endonuclease III; Region: ENDO3c; smart00478
937777005178	minor groove reading motif; other site
937777005179	helix-hairpin-helix signature motif; other site
937777005180	substrate binding pocket [chemical binding]; other site
937777005181	active site
937777005182	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
937777005183	dimer interface [polypeptide binding]; other site
937777005184	[2Fe-2S] cluster binding site [ion binding]; other site
937777005185	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
937777005186	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
937777005187	Walker A/P-loop; other site
937777005188	ATP binding site [chemical binding]; other site
937777005189	Q-loop/lid; other site
937777005190	ABC transporter signature motif; other site
937777005191	Walker B; other site
937777005192	D-loop; other site
937777005193	H-loop/switch region; other site
937777005194	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
937777005195	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
937777005196	ABC-ATPase subunit  interface; other site
937777005197	dimer interface [polypeptide binding]; other site
937777005198	putative PBP binding regions; other site
937777005199	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
937777005200	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
937777005201	Septum formation initiator; Region: DivIC; cl17659
937777005202	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
937777005203	active site
937777005204	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
937777005205	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
937777005206	nucleotide binding site [chemical binding]; other site
937777005207	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
937777005208	Major Facilitator Superfamily; Region: MFS_1; pfam07690
937777005209	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
937777005210	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
937777005211	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
937777005212	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
937777005213	catalytic residue [active]
937777005214	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
937777005215	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
937777005216	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
937777005217	classical (c) SDRs; Region: SDR_c; cd05233
937777005218	NAD(P) binding site [chemical binding]; other site
937777005219	active site
937777005220	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
937777005221	cheY-homologous receiver domain; Region: REC; smart00448
937777005222	active site
937777005223	phosphorylation site [posttranslational modification]
937777005224	intermolecular recognition site; other site
937777005225	dimerization interface [polypeptide binding]; other site
937777005226	Response regulator receiver domain; Region: Response_reg; pfam00072
937777005227	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777005228	active site
937777005229	phosphorylation site [posttranslational modification]
937777005230	intermolecular recognition site; other site
937777005231	dimerization interface [polypeptide binding]; other site
937777005232	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
937777005233	dimerization interface [polypeptide binding]; other site
937777005234	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777005235	dimer interface [polypeptide binding]; other site
937777005236	phosphorylation site [posttranslational modification]
937777005237	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777005238	ATP binding site [chemical binding]; other site
937777005239	Mg2+ binding site [ion binding]; other site
937777005240	G-X-G motif; other site
937777005241	Transcriptional regulators [Transcription]; Region: PurR; COG1609
937777005242	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
937777005243	DNA binding site [nucleotide binding]
937777005244	domain linker motif; other site
937777005245	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
937777005246	ligand binding site [chemical binding]; other site
937777005247	dimerization interface [polypeptide binding]; other site
937777005248	alpha-galactosidase; Provisional; Region: PRK15076
937777005249	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
937777005250	NAD binding site [chemical binding]; other site
937777005251	sugar binding site [chemical binding]; other site
937777005252	divalent metal binding site [ion binding]; other site
937777005253	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
937777005254	dimer interface [polypeptide binding]; other site
937777005255	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
937777005256	active site
937777005257	catalytic residues [active]
937777005258	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
937777005259	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
937777005260	oligomer interface [polypeptide binding]; other site
937777005261	active site
937777005262	metal binding site [ion binding]; metal-binding site
937777005263	Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827
937777005264	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782
937777005265	active site
937777005266	RNA/DNA hybrid binding site [nucleotide binding]; other site
937777005267	Predicted integral membrane protein [Function unknown]; Region: COG5637
937777005268	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
937777005269	putative hydrophobic ligand binding site [chemical binding]; other site
937777005270	short chain dehydrogenase; Provisional; Region: PRK06701
937777005271	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
937777005272	NAD binding site [chemical binding]; other site
937777005273	metal binding site [ion binding]; metal-binding site
937777005274	active site
937777005275	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
937777005276	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
937777005277	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777005278	dimer interface [polypeptide binding]; other site
937777005279	conserved gate region; other site
937777005280	putative PBP binding loops; other site
937777005281	ABC-ATPase subunit interface; other site
937777005282	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
937777005283	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777005284	dimer interface [polypeptide binding]; other site
937777005285	conserved gate region; other site
937777005286	putative PBP binding loops; other site
937777005287	ABC-ATPase subunit interface; other site
937777005288	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
937777005289	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
937777005290	Transcriptional regulators [Transcription]; Region: PurR; COG1609
937777005291	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
937777005292	DNA binding site [nucleotide binding]
937777005293	domain linker motif; other site
937777005294	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
937777005295	dimerization interface [polypeptide binding]; other site
937777005296	ligand binding site [chemical binding]; other site
937777005297	Protein of unknown function (DUF2961); Region: DUF2961; pfam11175
937777005298	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
937777005299	hexamer (dimer of trimers) interface [polypeptide binding]; other site
937777005300	substrate binding site [chemical binding]; other site
937777005301	trimer interface [polypeptide binding]; other site
937777005302	Mn binding site [ion binding]; other site
937777005303	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
937777005304	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804
937777005305	N- and C-terminal domain interface [polypeptide binding]; other site
937777005306	putative active site [active]
937777005307	MgATP binding site [chemical binding]; other site
937777005308	catalytic site [active]
937777005309	metal binding site [ion binding]; metal-binding site
937777005310	putative xylulose binding site [chemical binding]; other site
937777005311	putative homodimer interface [polypeptide binding]; other site
937777005312	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
937777005313	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
937777005314	active site
937777005315	PHP-associated; Region: PHP_C; pfam13263
937777005316	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
937777005317	Alcohol dehydrogenase GroES-like domain; Region: ADH_N; pfam08240
937777005318	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
937777005319	putative NAD(P) binding site [chemical binding]; other site
937777005320	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
937777005321	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
937777005322	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
937777005323	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
937777005324	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
937777005325	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
937777005326	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
937777005327	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
937777005328	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
937777005329	homotrimer interaction site [polypeptide binding]; other site
937777005330	putative active site [active]
937777005331	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
937777005332	active site
937777005333	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
937777005334	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
937777005335	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
937777005336	dimer interface [polypeptide binding]; other site
937777005337	motif 1; other site
937777005338	active site
937777005339	motif 2; other site
937777005340	motif 3; other site
937777005341	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
937777005342	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
937777005343	putative tRNA-binding site [nucleotide binding]; other site
937777005344	B3/4 domain; Region: B3_4; pfam03483
937777005345	tRNA synthetase B5 domain; Region: B5; smart00874
937777005346	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
937777005347	dimer interface [polypeptide binding]; other site
937777005348	motif 1; other site
937777005349	motif 3; other site
937777005350	motif 2; other site
937777005351	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
937777005352	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
937777005353	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
937777005354	active site
937777005355	DNA binding site [nucleotide binding]
937777005356	Int/Topo IB signature motif; other site
937777005357	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
937777005358	CheB methylesterase; Region: CheB_methylest; pfam01339
937777005359	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
937777005360	putative FMN binding site [chemical binding]; other site
937777005361	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
937777005362	active site
937777005363	catalytic triad [active]
937777005364	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; cl01930
937777005365	Response regulator receiver domain; Region: Response_reg; pfam00072
937777005366	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777005367	active site
937777005368	phosphorylation site [posttranslational modification]
937777005369	intermolecular recognition site; other site
937777005370	dimerization interface [polypeptide binding]; other site
937777005371	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
937777005372	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
937777005373	RNA polymerase sigma factor; Provisional; Region: PRK12519
937777005374	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
937777005375	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
937777005376	putative metal binding site [ion binding]; other site
937777005377	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
937777005378	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
937777005379	putative metal binding site [ion binding]; other site
937777005380	Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110
937777005381	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
937777005382	putative metal binding site [ion binding]; other site
937777005383	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
937777005384	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
937777005385	putative metal binding site [ion binding]; other site
937777005386	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
937777005387	metal ion-dependent adhesion site (MIDAS); other site
937777005388	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
937777005389	hypothetical protein; Provisional; Region: PRK10621
937777005390	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
937777005391	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
937777005392	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
937777005393	active site
937777005394	catalytic site [active]
937777005395	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
937777005396	nucleoside/Zn binding site; other site
937777005397	dimer interface [polypeptide binding]; other site
937777005398	catalytic motif [active]
937777005399	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
937777005400	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
937777005401	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
937777005402	DNA polymerase type-B family; Region: POLBc; smart00486
937777005403	active site
937777005404	catalytic site [active]
937777005405	substrate binding site [chemical binding]; other site
937777005406	DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023
937777005407	active site
937777005408	metal-binding site
937777005409	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
937777005410	Walker A motif; other site
937777005411	ATP binding site [chemical binding]; other site
937777005412	Walker B motif; other site
937777005413	Putative metallopeptidase domain; Region: DUF2201_N; pfam13203
937777005414	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
937777005415	metal ion-dependent adhesion site (MIDAS); other site
937777005416	HD domain; Region: HD_3; pfam13023
937777005417	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
937777005418	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
937777005419	generic binding surface II; other site
937777005420	generic binding surface I; other site
937777005421	Exonuclease VII, large subunit; Region: Exonuc_VII_L; pfam02601
937777005422	Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609
937777005423	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
937777005424	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
937777005425	GTPase CgtA; Reviewed; Region: obgE; PRK12297
937777005426	GTP1/OBG; Region: GTP1_OBG; pfam01018
937777005427	Obg GTPase; Region: Obg; cd01898
937777005428	G1 box; other site
937777005429	GTP/Mg2+ binding site [chemical binding]; other site
937777005430	Switch I region; other site
937777005431	G2 box; other site
937777005432	G3 box; other site
937777005433	Switch II region; other site
937777005434	G4 box; other site
937777005435	G5 box; other site
937777005436	Domain of unknown function (DUF1967); Region: DUF1967; cl07779
937777005437	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
937777005438	Zn2+ binding site [ion binding]; other site
937777005439	Mg2+ binding site [ion binding]; other site
937777005440	Transcriptional regulator [Transcription]; Region: LytR; COG1316
937777005441	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
937777005442	Oligomerisation domain; Region: Oligomerisation; pfam02410
937777005443	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
937777005444	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777005445	ATP binding site [chemical binding]; other site
937777005446	Mg2+ binding site [ion binding]; other site
937777005447	G-X-G motif; other site
937777005448	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
937777005449	Moco binding site; other site
937777005450	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
937777005451	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
937777005452	putative [4Fe-4S] binding site [ion binding]; other site
937777005453	putative molybdopterin cofactor binding site [chemical binding]; other site
937777005454	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
937777005455	putative molybdopterin cofactor binding site; other site
937777005456	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
937777005457	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
937777005458	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
937777005459	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
937777005460	active site
937777005461	PHP-associated; Region: PHP_C; pfam13263
937777005462	Fic family protein [Function unknown]; Region: COG3177
937777005463	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
937777005464	Fic/DOC family; Region: Fic; pfam02661
937777005465	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
937777005466	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
937777005467	Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123
937777005468	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
937777005469	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
937777005470	Terminase-like family; Region: Terminase_6; pfam03237
937777005471	VRR-NUC domain; Region: VRR_NUC; pfam08774
937777005472	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
937777005473	non-specific DNA binding site [nucleotide binding]; other site
937777005474	salt bridge; other site
937777005475	sequence-specific DNA binding site [nucleotide binding]; other site
937777005476	DdrB-like protein; Region: DdrB; pfam12747
937777005477	Helix-turn-helix domain; Region: HTH_17; pfam12728
937777005478	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
937777005479	non-specific DNA binding site [nucleotide binding]; other site
937777005480	salt bridge; other site
937777005481	sequence-specific DNA binding site [nucleotide binding]; other site
937777005482	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
937777005483	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
937777005484	non-specific DNA binding site [nucleotide binding]; other site
937777005485	salt bridge; other site
937777005486	sequence-specific DNA binding site [nucleotide binding]; other site
937777005487	Domain of unknown function (DUF4393); Region: DUF4393; pfam14337
937777005488	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
937777005489	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
937777005490	Int/Topo IB signature motif; other site
937777005491	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
937777005492	non-specific DNA binding site [nucleotide binding]; other site
937777005493	salt bridge; other site
937777005494	sequence-specific DNA binding site [nucleotide binding]; other site
937777005495	Domain of unknown function (DUF3846); Region: DUF3846; pfam12957
937777005496	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777005497	Response regulator receiver domain; Region: Response_reg; pfam00072
937777005498	active site
937777005499	phosphorylation site [posttranslational modification]
937777005500	intermolecular recognition site; other site
937777005501	dimerization interface [polypeptide binding]; other site
937777005502	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
937777005503	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777005504	dimer interface [polypeptide binding]; other site
937777005505	phosphorylation site [posttranslational modification]
937777005506	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777005507	ATP binding site [chemical binding]; other site
937777005508	Mg2+ binding site [ion binding]; other site
937777005509	G-X-G motif; other site
937777005510	Response regulator receiver domain; Region: Response_reg; pfam00072
937777005511	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777005512	active site
937777005513	phosphorylation site [posttranslational modification]
937777005514	intermolecular recognition site; other site
937777005515	dimerization interface [polypeptide binding]; other site
937777005516	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
937777005517	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777005518	active site
937777005519	phosphorylation site [posttranslational modification]
937777005520	intermolecular recognition site; other site
937777005521	dimerization interface [polypeptide binding]; other site
937777005522	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
937777005523	DNA binding site [nucleotide binding]
937777005524	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
937777005525	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
937777005526	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
937777005527	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
937777005528	amidase catalytic site [active]
937777005529	Zn binding residues [ion binding]; other site
937777005530	substrate binding site [chemical binding]; other site
937777005531	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
937777005532	active site
937777005533	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
937777005534	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
937777005535	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
937777005536	NlpC/P60 family; Region: NLPC_P60; cl17555
937777005537	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
937777005538	active site
937777005539	Myosin tail; Region: Myosin_tail_1; pfam01576
937777005540	Prohead core protein protease; Region: Peptidase_U9; cl11614
937777005541	Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306
937777005542	protein-splicing catalytic site; other site
937777005543	thioester formation/cholesterol transfer; other site
937777005544	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
937777005545	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
937777005546	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
937777005547	ParB-like nuclease domain; Region: ParB; smart00470
937777005548	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
937777005549	DNA methylase; Region: N6_N4_Mtase; pfam01555
937777005550	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
937777005551	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
937777005552	PAS fold; Region: PAS_4; pfam08448
937777005553	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777005554	putative active site [active]
937777005555	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777005556	ATP binding site [chemical binding]; other site
937777005557	Mg2+ binding site [ion binding]; other site
937777005558	G-X-G motif; other site
937777005559	Response regulator receiver domain; Region: Response_reg; pfam00072
937777005560	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777005561	active site
937777005562	phosphorylation site [posttranslational modification]
937777005563	intermolecular recognition site; other site
937777005564	dimerization interface [polypeptide binding]; other site
937777005565	PAS fold; Region: PAS_4; pfam08448
937777005566	GAF domain; Region: GAF_3; pfam13492
937777005567	GAF domain; Region: GAF_2; pfam13185
937777005568	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777005569	putative active site [active]
937777005570	heme pocket [chemical binding]; other site
937777005571	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
937777005572	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777005573	dimer interface [polypeptide binding]; other site
937777005574	phosphorylation site [posttranslational modification]
937777005575	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777005576	ATP binding site [chemical binding]; other site
937777005577	Mg2+ binding site [ion binding]; other site
937777005578	G-X-G motif; other site
937777005579	Response regulator receiver domain; Region: Response_reg; pfam00072
937777005580	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777005581	active site
937777005582	phosphorylation site [posttranslational modification]
937777005583	intermolecular recognition site; other site
937777005584	dimerization interface [polypeptide binding]; other site
937777005585	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
937777005586	sequence-specific DNA binding site [nucleotide binding]; other site
937777005587	salt bridge; other site
937777005588	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
937777005589	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
937777005590	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
937777005591	active site
937777005592	catalytic site [active]
937777005593	substrate binding site [chemical binding]; other site
937777005594	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
937777005595	Catalytic site; other site
937777005596	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
937777005597	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
937777005598	cofactor binding site; other site
937777005599	DNA binding site [nucleotide binding]
937777005600	substrate interaction site [chemical binding]; other site
937777005601	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
937777005602	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
937777005603	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
937777005604	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
937777005605	replicative DNA helicase; Region: DnaB; TIGR00665
937777005606	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
937777005607	Walker A motif; other site
937777005608	ATP binding site [chemical binding]; other site
937777005609	Walker B motif; other site
937777005610	DNA binding loops [nucleotide binding]
937777005611	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
937777005612	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
937777005613	ERF superfamily; Region: ERF; pfam04404
937777005614	Helix-turn-helix domain; Region: HTH_17; pfam12728
937777005615	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
937777005616	non-specific DNA binding site [nucleotide binding]; other site
937777005617	salt bridge; other site
937777005618	sequence-specific DNA binding site [nucleotide binding]; other site
937777005619	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
937777005620	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
937777005621	Int/Topo IB signature motif; other site
937777005622	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
937777005623	active site
937777005624	homotetramer interface [polypeptide binding]; other site
937777005625	homodimer interface [polypeptide binding]; other site
937777005626	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
937777005627	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
937777005628	active site
937777005629	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
937777005630	sugar binding site [chemical binding]; other site
937777005631	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
937777005632	threonine synthase; Reviewed; Region: PRK06721
937777005633	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
937777005634	homodimer interface [polypeptide binding]; other site
937777005635	pyridoxal 5'-phosphate binding site [chemical binding]; other site
937777005636	catalytic residue [active]
937777005637	homoserine kinase; Provisional; Region: PRK01212
937777005638	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
937777005639	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
937777005640	UbiA prenyltransferase family; Region: UbiA; pfam01040
937777005641	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
937777005642	cyclase homology domain; Region: CHD; cd07302
937777005643	nucleotidyl binding site; other site
937777005644	metal binding site [ion binding]; metal-binding site
937777005645	dimer interface [polypeptide binding]; other site
937777005646	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
937777005647	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777005648	active site
937777005649	phosphorylation site [posttranslational modification]
937777005650	intermolecular recognition site; other site
937777005651	dimerization interface [polypeptide binding]; other site
937777005652	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
937777005653	DNA binding site [nucleotide binding]
937777005654	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
937777005655	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
937777005656	dimerization interface [polypeptide binding]; other site
937777005657	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777005658	dimer interface [polypeptide binding]; other site
937777005659	phosphorylation site [posttranslational modification]
937777005660	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777005661	ATP binding site [chemical binding]; other site
937777005662	Mg2+ binding site [ion binding]; other site
937777005663	G-X-G motif; other site
937777005664	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3877
937777005665	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
937777005666	CrcB-like protein; Region: CRCB; pfam02537
937777005667	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
937777005668	RNB domain; Region: RNB; pfam00773
937777005669	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14618
937777005670	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
937777005671	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
937777005672	Methyltransferase domain; Region: Methyltransf_31; pfam13847
937777005673	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
937777005674	S-adenosylmethionine binding site [chemical binding]; other site
937777005675	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
937777005676	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
937777005677	active site
937777005678	Zn binding site [ion binding]; other site
937777005679	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
937777005680	dinuclear metal binding motif [ion binding]; other site
937777005681	Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316
937777005682	Ion channel; Region: Ion_trans_2; pfam07885
937777005683	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
937777005684	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
937777005685	beta-galactosidase; Region: BGL; TIGR03356
937777005686	Response regulator receiver domain; Region: Response_reg; pfam00072
937777005687	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777005688	active site
937777005689	phosphorylation site [posttranslational modification]
937777005690	intermolecular recognition site; other site
937777005691	dimerization interface [polypeptide binding]; other site
937777005692	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777005693	PAS domain; Region: PAS_9; pfam13426
937777005694	putative active site [active]
937777005695	heme pocket [chemical binding]; other site
937777005696	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
937777005697	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
937777005698	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
937777005699	PAS domain S-box; Region: sensory_box; TIGR00229
937777005700	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777005701	putative active site [active]
937777005702	heme pocket [chemical binding]; other site
937777005703	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777005704	PAS fold; Region: PAS_3; pfam08447
937777005705	putative active site [active]
937777005706	heme pocket [chemical binding]; other site
937777005707	GAF domain; Region: GAF_3; pfam13492
937777005708	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
937777005709	GAF domain; Region: GAF; pfam01590
937777005710	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777005711	dimer interface [polypeptide binding]; other site
937777005712	phosphorylation site [posttranslational modification]
937777005713	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777005714	ATP binding site [chemical binding]; other site
937777005715	Mg2+ binding site [ion binding]; other site
937777005716	G-X-G motif; other site
937777005717	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
937777005718	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
937777005719	active site
937777005720	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
937777005721	ATP binding site [chemical binding]; other site
937777005722	putative Mg++ binding site [ion binding]; other site
937777005723	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
937777005724	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
937777005725	nucleotide binding region [chemical binding]; other site
937777005726	ATP-binding site [chemical binding]; other site
937777005727	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
937777005728	nucleotide binding region [chemical binding]; other site
937777005729	ATP-binding site [chemical binding]; other site
937777005730	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
937777005731	Putative catalytic domain of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar4; cd09132
937777005732	PLD-like domain; Region: PLDc_2; pfam13091
937777005733	putative active site [active]
937777005734	putative catalytic site [active]
937777005735	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
937777005736	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
937777005737	cofactor binding site; other site
937777005738	DNA binding site [nucleotide binding]
937777005739	substrate interaction site [chemical binding]; other site
937777005740	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
937777005741	additional DNA contacts [nucleotide binding]; other site
937777005742	mismatch recognition site; other site
937777005743	active site
937777005744	zinc binding site [ion binding]; other site
937777005745	DNA intercalation site [nucleotide binding]; other site
937777005746	Archaebacterial flagellin; Region: Arch_flagellin; cl00732
937777005747	hypothetical protein; Provisional; Region: PRK06153
937777005748	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
937777005749	ATP binding site [chemical binding]; other site
937777005750	substrate interface [chemical binding]; other site
937777005751	Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452
937777005752	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
937777005753	non-specific DNA binding site [nucleotide binding]; other site
937777005754	salt bridge; other site
937777005755	sequence-specific DNA binding site [nucleotide binding]; other site
937777005756	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
937777005757	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
937777005758	Int/Topo IB signature motif; other site
937777005759	Domain of unknown function (DUF927); Region: DUF927; cl12098
937777005760	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
937777005761	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
937777005762	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
937777005763	Int/Topo IB signature motif; other site
937777005764	Helix-turn-helix domain; Region: HTH_17; cl17695
937777005765	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
937777005766	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
937777005767	non-specific DNA binding site [nucleotide binding]; other site
937777005768	salt bridge; other site
937777005769	sequence-specific DNA binding site [nucleotide binding]; other site
937777005770	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
937777005771	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
937777005772	active site
937777005773	catalytic residues [active]
937777005774	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
937777005775	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
937777005776	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
937777005777	Divergent AAA domain; Region: AAA_4; pfam04326
937777005778	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
937777005779	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864
937777005780	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
937777005781	metal ion-dependent adhesion site (MIDAS); other site
937777005782	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
937777005783	Walker A motif; other site
937777005784	ATP binding site [chemical binding]; other site
937777005785	Walker B motif; other site
937777005786	arginine finger; other site
937777005787	PLD-like domain; Region: PLDc_2; pfam13091
937777005788	Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117
937777005789	homodimer interface [polypeptide binding]; other site
937777005790	putative active site [active]
937777005791	catalytic site [active]
937777005792	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
937777005793	Divergent AAA domain; Region: AAA_4; pfam04326
937777005794	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
937777005795	DDE superfamily endonuclease; Region: DDE_3; pfam13358
937777005796	Homeodomain-like domain; Region: HTH_23; pfam13384
937777005797	Winged helix-turn helix; Region: HTH_29; pfam13551
937777005798	Winged helix-turn helix; Region: HTH_33; pfam13592
937777005799	AzlC protein; Region: AzlC; pfam03591
937777005800	Predicted membrane protein [Function unknown]; Region: COG4392
937777005801	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
937777005802	Domain of unknown function (DUF305); Region: DUF305; pfam03713
937777005803	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
937777005804	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777005805	active site
937777005806	phosphorylation site [posttranslational modification]
937777005807	intermolecular recognition site; other site
937777005808	dimerization interface [polypeptide binding]; other site
937777005809	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
937777005810	DNA binding site [nucleotide binding]
937777005811	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
937777005812	dimerization interface [polypeptide binding]; other site
937777005813	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
937777005814	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777005815	dimer interface [polypeptide binding]; other site
937777005816	phosphorylation site [posttranslational modification]
937777005817	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777005818	ATP binding site [chemical binding]; other site
937777005819	Mg2+ binding site [ion binding]; other site
937777005820	G-X-G motif; other site
937777005821	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
937777005822	dimerization interface [polypeptide binding]; other site
937777005823	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
937777005824	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
937777005825	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
937777005826	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
937777005827	Amidohydrolase; Region: Amidohydro_2; pfam04909
937777005828	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
937777005829	catalytic core [active]
937777005830	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
937777005831	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
937777005832	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
937777005833	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
937777005834	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
937777005835	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
937777005836	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
937777005837	Transposase; Region: HTH_Tnp_1; pfam01527
937777005838	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
937777005839	putative transposase OrfB; Reviewed; Region: PHA02517
937777005840	HTH-like domain; Region: HTH_21; pfam13276
937777005841	Integrase core domain; Region: rve; pfam00665
937777005842	Integrase core domain; Region: rve_3; pfam13683
937777005843	HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008
937777005844	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
937777005845	Cupin domain; Region: Cupin_2; pfam07883
937777005846	Cupin domain; Region: Cupin_2; pfam07883
937777005847	Hypothetical protein TTHB210, a sigma(E)-regulated gene product found in Thermus thermophilus, and similar proteins; Region: TTHB210-like; cd11669
937777005848	oligomer interface [polypeptide binding]; other site
937777005849	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
937777005850	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
937777005851	active site
937777005852	DNA polymerase IV; Validated; Region: PRK02406
937777005853	DNA binding site [nucleotide binding]
937777005854	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
937777005855	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
937777005856	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
937777005857	ABC transporter signature motif; other site
937777005858	Walker B; other site
937777005859	D-loop; other site
937777005860	H-loop/switch region; other site
937777005861	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
937777005862	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
937777005863	HD domain; Region: HD_4; pfam13328
937777005864	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
937777005865	Transposase; Region: HTH_Tnp_1; pfam01527
937777005866	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
937777005867	active site
937777005868	oxyanion hole [active]
937777005869	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
937777005870	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
937777005871	active site
937777005872	catalytic tetrad [active]
937777005873	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
937777005874	Glycerophosphodiester phosphodiesterase domain of putative Agrobacterium tumefaciens glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_pAtGDE_like; cd08565
937777005875	active site
937777005876	catalytic site [active]
937777005877	metal binding site [ion binding]; metal-binding site
937777005878	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
937777005879	catalytic core [active]
937777005880	Protein of unknown function (DUF664); Region: DUF664; pfam04978
937777005881	DinB superfamily; Region: DinB_2; pfam12867
937777005882	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
937777005883	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
937777005884	Glycosyl hydrolase family 52; Region: Glyco_hydro_52; pfam03512
937777005885	HTH domain; Region: HTH_11; cl17392
937777005886	birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121
937777005887	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
937777005888	BioY family; Region: BioY; pfam02632
937777005889	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
937777005890	active site
937777005891	Domain of unknown function (DUF2382); Region: DUF2382; pfam09557
937777005892	PRC-barrel domain; Region: PRC; pfam05239
937777005893	Domain of unknown function (DUF2382); Region: DUF2382; cl01590
937777005894	Domain of unknown function (DUF2382); Region: DUF2382; pfam09557
937777005895	PRC-barrel domain; Region: PRC; pfam05239
937777005896	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861
937777005897	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
937777005898	DNA polymerase III subunit delta'; Validated; Region: PRK08485
937777005899	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
937777005900	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
937777005901	active site
937777005902	metal binding site [ion binding]; metal-binding site
937777005903	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
937777005904	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
937777005905	catalytic triad [active]
937777005906	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
937777005907	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
937777005908	FeS/SAM binding site; other site
937777005909	HemN C-terminal domain; Region: HemN_C; pfam06969
937777005910	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
937777005911	metal binding site [ion binding]; metal-binding site
937777005912	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
937777005913	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
937777005914	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
937777005915	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
937777005916	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331
937777005917	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
937777005918	active site
937777005919	catalytic site [active]
937777005920	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
937777005921	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133
937777005922	Transcriptional regulator [Transcription]; Region: LytR; COG1316
937777005923	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
937777005924	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
937777005925	active site
937777005926	catalytic residues [active]
937777005927	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
937777005928	active site
937777005929	catalytic residues [active]
937777005930	Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988
937777005931	Methyltransferase domain; Region: Methyltransf_23; pfam13489
937777005932	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
937777005933	S-adenosylmethionine binding site [chemical binding]; other site
937777005934	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
937777005935	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959
937777005936	NodB motif; other site
937777005937	putative active site [active]
937777005938	putative catalytic site [active]
937777005939	putative Zn binding site [ion binding]; other site
937777005940	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
937777005941	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
937777005942	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
937777005943	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
937777005944	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
937777005945	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
937777005946	rod shape-determining protein MreB; Provisional; Region: PRK13927
937777005947	MreB and similar proteins; Region: MreB_like; cd10225
937777005948	nucleotide binding site [chemical binding]; other site
937777005949	Mg binding site [ion binding]; other site
937777005950	putative protofilament interaction site [polypeptide binding]; other site
937777005951	RodZ interaction site [polypeptide binding]; other site
937777005952	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
937777005953	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
937777005954	motif II; other site
937777005955	CCC1-related family of proteins; Region: CCC1_like; cl00278
937777005956	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
937777005957	Major Facilitator Superfamily; Region: MFS_1; pfam07690
937777005958	putative substrate translocation pore; other site
937777005959	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
937777005960	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777005961	active site
937777005962	phosphorylation site [posttranslational modification]
937777005963	intermolecular recognition site; other site
937777005964	dimerization interface [polypeptide binding]; other site
937777005965	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
937777005966	DNA binding site [nucleotide binding]
937777005967	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
937777005968	Major Facilitator Superfamily; Region: MFS_1; pfam07690
937777005969	putative substrate translocation pore; other site
937777005970	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
937777005971	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
937777005972	metal binding site [ion binding]; metal-binding site
937777005973	active site
937777005974	I-site; other site
937777005975	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
937777005976	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
937777005977	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
937777005978	metal binding site [ion binding]; metal-binding site
937777005979	active site
937777005980	I-site; other site
937777005981	Phospholipid methyltransferase; Region: PEMT; cl17370
937777005982	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
937777005983	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
937777005984	malonyl-CoA binding site [chemical binding]; other site
937777005985	dimer interface [polypeptide binding]; other site
937777005986	active site
937777005987	product binding site; other site
937777005988	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
937777005989	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
937777005990	active site
937777005991	catalytic tetrad [active]
937777005992	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
937777005993	FMN binding site [chemical binding]; other site
937777005994	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
937777005995	dimer interface [polypeptide binding]; other site
937777005996	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
937777005997	DNA protecting protein DprA; Region: dprA; TIGR00732
937777005998	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
937777005999	Beta-lactamase; Region: Beta-lactamase; cl17358
937777006000	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
937777006001	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
937777006002	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
937777006003	DNA-binding site [nucleotide binding]; DNA binding site
937777006004	UTRA domain; Region: UTRA; pfam07702
937777006005	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
937777006006	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
937777006007	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
937777006008	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777006009	dimer interface [polypeptide binding]; other site
937777006010	conserved gate region; other site
937777006011	putative PBP binding loops; other site
937777006012	ABC-ATPase subunit interface; other site
937777006013	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
937777006014	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
937777006015	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777006016	dimer interface [polypeptide binding]; other site
937777006017	conserved gate region; other site
937777006018	putative PBP binding loops; other site
937777006019	ABC-ATPase subunit interface; other site
937777006020	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
937777006021	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
937777006022	putative active site [active]
937777006023	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
937777006024	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
937777006025	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
937777006026	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
937777006027	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
937777006028	oligomer interface [polypeptide binding]; other site
937777006029	metal binding site [ion binding]; metal-binding site
937777006030	metal binding site [ion binding]; metal-binding site
937777006031	putative Cl binding site [ion binding]; other site
937777006032	aspartate ring; other site
937777006033	basic sphincter; other site
937777006034	hydrophobic gate; other site
937777006035	periplasmic entrance; other site
937777006036	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
937777006037	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
937777006038	Walker A motif; other site
937777006039	ATP binding site [chemical binding]; other site
937777006040	Walker B motif; other site
937777006041	arginine finger; other site
937777006042	PRC-barrel domain; Region: PRC; pfam05239
937777006043	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861
937777006044	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
937777006045	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777006046	active site
937777006047	phosphorylation site [posttranslational modification]
937777006048	intermolecular recognition site; other site
937777006049	dimerization interface [polypeptide binding]; other site
937777006050	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
937777006051	DNA binding residues [nucleotide binding]
937777006052	dimerization interface [polypeptide binding]; other site
937777006053	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
937777006054	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777006055	dimer interface [polypeptide binding]; other site
937777006056	phosphorylation site [posttranslational modification]
937777006057	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777006058	ATP binding site [chemical binding]; other site
937777006059	Mg2+ binding site [ion binding]; other site
937777006060	G-X-G motif; other site
937777006061	GTP-binding protein LepA; Provisional; Region: PRK05433
937777006062	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
937777006063	G1 box; other site
937777006064	putative GEF interaction site [polypeptide binding]; other site
937777006065	GTP/Mg2+ binding site [chemical binding]; other site
937777006066	Switch I region; other site
937777006067	G2 box; other site
937777006068	G3 box; other site
937777006069	Switch II region; other site
937777006070	G4 box; other site
937777006071	G5 box; other site
937777006072	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
937777006073	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
937777006074	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
937777006075	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
937777006076	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
937777006077	PA/protease or protease-like domain interface [polypeptide binding]; other site
937777006078	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
937777006079	Peptidase family M28; Region: Peptidase_M28; pfam04389
937777006080	metal binding site [ion binding]; metal-binding site
937777006081	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
937777006082	dimerization interface [polypeptide binding]; other site
937777006083	putative DNA binding site [nucleotide binding]; other site
937777006084	putative Zn2+ binding site [ion binding]; other site
937777006085	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777006086	PAS domain; Region: PAS_9; pfam13426
937777006087	putative active site [active]
937777006088	heme pocket [chemical binding]; other site
937777006089	PAS fold; Region: PAS_4; pfam08448
937777006090	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
937777006091	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
937777006092	GAF domain; Region: GAF_3; pfam13492
937777006093	PAS fold; Region: PAS; pfam00989
937777006094	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
937777006095	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777006096	putative active site [active]
937777006097	heme pocket [chemical binding]; other site
937777006098	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777006099	dimer interface [polypeptide binding]; other site
937777006100	phosphorylation site [posttranslational modification]
937777006101	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777006102	ATP binding site [chemical binding]; other site
937777006103	Mg2+ binding site [ion binding]; other site
937777006104	G-X-G motif; other site
937777006105	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
937777006106	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
937777006107	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
937777006108	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
937777006109	putative dimer interface [polypeptide binding]; other site
937777006110	N-terminal domain interface [polypeptide binding]; other site
937777006111	putative substrate binding pocket (H-site) [chemical binding]; other site
937777006112	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
937777006113	Coenzyme A binding pocket [chemical binding]; other site
937777006114	Predicted transcriptional regulators [Transcription]; Region: COG1733
937777006115	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
937777006116	DoxX; Region: DoxX; pfam07681
937777006117	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
937777006118	NADH(P)-binding; Region: NAD_binding_10; pfam13460
937777006119	NAD binding site [chemical binding]; other site
937777006120	substrate binding site [chemical binding]; other site
937777006121	putative active site [active]
937777006122	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
937777006123	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
937777006124	putative metal binding site [ion binding]; other site
937777006125	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
937777006126	active site
937777006127	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
937777006128	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
937777006129	Zn binding site [ion binding]; other site
937777006130	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
937777006131	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
937777006132	Zn binding site [ion binding]; other site
937777006133	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
937777006134	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
937777006135	Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842
937777006136	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
937777006137	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
937777006138	Allophanate hydrolase subunit 2; Region: AHS2; cl00865
937777006139	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
937777006140	putative active site [active]
937777006141	CAAX protease self-immunity; Region: Abi; pfam02517
937777006142	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
937777006143	dimerization interface [polypeptide binding]; other site
937777006144	putative DNA binding site [nucleotide binding]; other site
937777006145	putative Zn2+ binding site [ion binding]; other site
937777006146	Predicted integral membrane protein [Function unknown]; Region: COG5658
937777006147	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
937777006148	Dodecin; Region: Dodecin; pfam07311
937777006149	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
937777006150	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
937777006151	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
937777006152	Rhs element Vgr protein; Region: vgr_GE; TIGR01646
937777006153	Phage protein D [General function prediction only]; Region: COG3500
937777006154	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
937777006155	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
937777006156	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
937777006157	active site
937777006158	ATP binding site [chemical binding]; other site
937777006159	substrate binding site [chemical binding]; other site
937777006160	activation loop (A-loop); other site
937777006161	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
937777006162	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
937777006163	phosphopeptide binding site; other site
937777006164	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
937777006165	phosphopeptide binding site; other site
937777006166	phage tail protein domain; Region: tail_TIGR02242
937777006167	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
937777006168	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
937777006169	HD domain; Region: HD_3; pfam13023
937777006170	Cupin domain; Region: Cupin_2; pfam07883
937777006171	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
937777006172	AIR carboxylase; Region: AIRC; cl00310
937777006173	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
937777006174	ATP-grasp domain; Region: ATP-grasp_4; cl17255
937777006175	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
937777006176	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
937777006177	substrate binding site [chemical binding]; other site
937777006178	ATP binding site [chemical binding]; other site
937777006179	YceG-like family; Region: YceG; pfam02618
937777006180	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
937777006181	dimerization interface [polypeptide binding]; other site
937777006182	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
937777006183	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
937777006184	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
937777006185	metal binding site 2 [ion binding]; metal-binding site
937777006186	putative DNA binding helix; other site
937777006187	metal binding site 1 [ion binding]; metal-binding site
937777006188	dimer interface [polypeptide binding]; other site
937777006189	structural Zn2+ binding site [ion binding]; other site
937777006190	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
937777006191	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
937777006192	putative NAD(P) binding site [chemical binding]; other site
937777006193	active site
937777006194	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
937777006195	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
937777006196	putative acyl-acceptor binding pocket; other site
937777006197	Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283
937777006198	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
937777006199	CMP-binding site; other site
937777006200	The sites determining sugar specificity; other site
937777006201	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
937777006202	active site
937777006203	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
937777006204	active site
937777006205	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
937777006206	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
937777006207	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
937777006208	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
937777006209	dimer interface [polypeptide binding]; other site
937777006210	acyl-activating enzyme (AAE) consensus motif; other site
937777006211	putative active site [active]
937777006212	AMP binding site [chemical binding]; other site
937777006213	putative CoA binding site [chemical binding]; other site
937777006214	GTP-binding protein Der; Reviewed; Region: PRK00093
937777006215	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
937777006216	G1 box; other site
937777006217	GTP/Mg2+ binding site [chemical binding]; other site
937777006218	Switch I region; other site
937777006219	G2 box; other site
937777006220	Switch II region; other site
937777006221	G3 box; other site
937777006222	G4 box; other site
937777006223	G5 box; other site
937777006224	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
937777006225	G1 box; other site
937777006226	GTP/Mg2+ binding site [chemical binding]; other site
937777006227	Switch I region; other site
937777006228	G2 box; other site
937777006229	G3 box; other site
937777006230	Switch II region; other site
937777006231	G4 box; other site
937777006232	G5 box; other site
937777006233	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
937777006234	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
937777006235	FUN14 family; Region: FUN14; pfam04930
937777006236	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
937777006237	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
937777006238	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
937777006239	DNA binding residues [nucleotide binding]
937777006240	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
937777006241	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
937777006242	intersubunit interface [polypeptide binding]; other site
937777006243	active site
937777006244	zinc binding site [ion binding]; other site
937777006245	Na+ binding site [ion binding]; other site
937777006246	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
937777006247	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
937777006248	GatB domain; Region: GatB_Yqey; smart00845
937777006249	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
937777006250	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
937777006251	active site
937777006252	catalytic site [active]
937777006253	substrate binding site [chemical binding]; other site
937777006254	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
937777006255	Ligand Binding Site [chemical binding]; other site
937777006256	Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590
937777006257	Predicted methyltransferases [General function prediction only]; Region: COG0313
937777006258	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
937777006259	putative SAM binding site [chemical binding]; other site
937777006260	putative homodimer interface [polypeptide binding]; other site
937777006261	6-phosphofructokinase; Provisional; Region: PRK03202
937777006262	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
937777006263	active site
937777006264	ADP/pyrophosphate binding site [chemical binding]; other site
937777006265	dimerization interface [polypeptide binding]; other site
937777006266	allosteric effector site; other site
937777006267	fructose-1,6-bisphosphate binding site; other site
937777006268	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
937777006269	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
937777006270	substrate binding site [chemical binding]; other site
937777006271	dimer interface [polypeptide binding]; other site
937777006272	ATP binding site [chemical binding]; other site
937777006273	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
937777006274	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
937777006275	Zn2+ binding site [ion binding]; other site
937777006276	Mg2+ binding site [ion binding]; other site
937777006277	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
937777006278	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
937777006279	nudix motif; other site
937777006280	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
937777006281	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
937777006282	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
937777006283	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
937777006284	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777006285	dimer interface [polypeptide binding]; other site
937777006286	conserved gate region; other site
937777006287	putative PBP binding loops; other site
937777006288	ABC-ATPase subunit interface; other site
937777006289	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
937777006290	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777006291	dimer interface [polypeptide binding]; other site
937777006292	ABC-ATPase subunit interface; other site
937777006293	putative PBP binding loops; other site
937777006294	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
937777006295	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
937777006296	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
937777006297	Predicted transcriptional regulator [Transcription]; Region: COG4189
937777006298	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
937777006299	dimerization interface [polypeptide binding]; other site
937777006300	putative DNA binding site [nucleotide binding]; other site
937777006301	putative Zn2+ binding site [ion binding]; other site
937777006302	Transposase; Region: DEDD_Tnp_IS110; pfam01548
937777006303	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
937777006304	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
937777006305	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
937777006306	Uncharacterized conserved protein, YhbC family [Function unknown]; Region: COG0782
937777006307	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
937777006308	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
937777006309	PEGA domain; Region: PEGA; pfam08308
937777006310	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
937777006311	dinuclear metal binding motif [ion binding]; other site
937777006312	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
937777006313	PLD-like domain; Region: PLDc_2; pfam13091
937777006314	putative active site [active]
937777006315	catalytic site [active]
937777006316	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
937777006317	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
937777006318	ATP binding site [chemical binding]; other site
937777006319	putative Mg++ binding site [ion binding]; other site
937777006320	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
937777006321	nucleotide binding region [chemical binding]; other site
937777006322	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
937777006323	Uncharacterized conserved protein [Function unknown]; Region: COG1479
937777006324	Protein of unknown function DUF262; Region: DUF262; pfam03235
937777006325	Protein of unknown function DUF262; Region: DUF262; pfam03235
937777006326	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
937777006327	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719
937777006328	GIY-YIG motif/motif A; other site
937777006329	active site
937777006330	catalytic site [active]
937777006331	metal binding site [ion binding]; metal-binding site
937777006332	tRNA synthetases class I (R); Region: tRNA-synt_1d; pfam00750
937777006333	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
937777006334	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
937777006335	Int/Topo IB signature motif; other site
937777006336	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
937777006337	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
937777006338	DNA binding residues [nucleotide binding]
937777006339	Prephenate dehydratase; Region: PDT; pfam00800
937777006340	Chorismate mutase type II; Region: CM_2; cl00693
937777006341	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
937777006342	Domain of unknown function (DUF955); Region: DUF955; cl01076
937777006343	Restriction endonuclease; Region: Mrr_cat; pfam04471
937777006344	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
937777006345	Divergent AAA domain; Region: AAA_4; pfam04326
937777006346	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
937777006347	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
937777006348	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
937777006349	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
937777006350	ATP binding site [chemical binding]; other site
937777006351	putative Mg++ binding site [ion binding]; other site
937777006352	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
937777006353	Protein of unknown function DUF45; Region: DUF45; pfam01863
937777006354	Protein of unknown function (DUF2764); Region: DUF2764; pfam10962
937777006355	Helix-turn-helix domain; Region: HTH_17; cl17695
937777006356	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
937777006357	FOG: CBS domain [General function prediction only]; Region: COG0517
937777006358	Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844
937777006359	Predicted membrane protein [Function unknown]; Region: COG2323
937777006360	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
937777006361	metal binding site [ion binding]; metal-binding site
937777006362	active site
937777006363	I-site; other site
937777006364	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
937777006365	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
937777006366	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
937777006367	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
937777006368	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
937777006369	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
937777006370	Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720
937777006371	VanW like protein; Region: VanW; pfam04294
937777006372	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
937777006373	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
937777006374	ParB-like nuclease domain; Region: ParB; smart00470
937777006375	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
937777006376	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
937777006377	P-loop; other site
937777006378	Magnesium ion binding site [ion binding]; other site
937777006379	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
937777006380	Magnesium ion binding site [ion binding]; other site
937777006381	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726
937777006382	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
937777006383	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
937777006384	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
937777006385	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
937777006386	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
937777006387	DnaA N-terminal domain; Region: DnaA_N; pfam11638
937777006388	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
937777006389	Walker A motif; other site
937777006390	ATP binding site [chemical binding]; other site
937777006391	Walker B motif; other site
937777006392	arginine finger; other site
937777006393	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
937777006394	DnaA box-binding interface [nucleotide binding]; other site
937777006395	DNA polymerase III subunit beta; Provisional; Region: PRK14945
937777006396	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
937777006397	putative DNA binding surface [nucleotide binding]; other site
937777006398	dimer interface [polypeptide binding]; other site
937777006399	beta-clamp/clamp loader binding surface; other site
937777006400	beta-clamp/translesion DNA polymerase binding surface; other site
937777006401	enolase; Provisional; Region: eno; PRK00077
937777006402	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
937777006403	dimer interface [polypeptide binding]; other site
937777006404	metal binding site [ion binding]; metal-binding site
937777006405	substrate binding pocket [chemical binding]; other site
937777006406	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
937777006407	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
937777006408	domain interfaces; other site
937777006409	active site
937777006410	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
937777006411	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
937777006412	active site
937777006413	HIGH motif; other site
937777006414	dimer interface [polypeptide binding]; other site
937777006415	KMSKS motif; other site
937777006416	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
937777006417	RNA binding surface [nucleotide binding]; other site
937777006418	MOSC domain; Region: MOSC; pfam03473
937777006419	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
937777006420	Family of unknown function (DUF633); Region: DUF633; pfam04816
937777006421	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
937777006422	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
937777006423	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
937777006424	active site
937777006425	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
937777006426	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
937777006427	active site
937777006428	catalytic tetrad [active]
937777006429	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
937777006430	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
937777006431	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
937777006432	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
937777006433	protein-splicing catalytic site; other site
937777006434	thioester formation/cholesterol transfer; other site
937777006435	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
937777006436	Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867
937777006437	TSCPD domain; Region: TSCPD; pfam12637
937777006438	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
937777006439	tellurite resistance protein terB; Region: terB; cd07176
937777006440	putative metal binding site [ion binding]; other site
937777006441	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
937777006442	Protein of unknown function (DUF2983); Region: DUF2983; pfam11202
937777006443	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
937777006444	active site
937777006445	Protein of unknown function (DUF3706); Region: DUF3706; pfam12500
937777006446	carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767
937777006447	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
937777006448	hypothetical protein; Provisional; Region: PRK14013
937777006449	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
937777006450	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
937777006451	putative metal binding site [ion binding]; other site
937777006452	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
937777006453	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
937777006454	putative metal binding site [ion binding]; other site
937777006455	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
937777006456	Domain of unknown function (DUF1802); Region: DUF1802; pfam08819
937777006457	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
937777006458	PilX N-terminal; Region: PilX_N; pfam14341
937777006459	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
937777006460	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
937777006461	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
937777006462	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
937777006463	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
937777006464	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
937777006465	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
937777006466	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
937777006467	oligomer interface [polypeptide binding]; other site
937777006468	active site residues [active]
937777006469	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
937777006470	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
937777006471	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
937777006472	Walker A motif; other site
937777006473	ATP binding site [chemical binding]; other site
937777006474	Walker B motif; other site
937777006475	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
937777006476	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
937777006477	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
937777006478	Walker A motif; other site
937777006479	ATP binding site [chemical binding]; other site
937777006480	Walker B motif; other site
937777006481	arginine finger; other site
937777006482	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
937777006483	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
937777006484	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
937777006485	active site
937777006486	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
937777006487	active site
937777006488	metal binding site 1 [ion binding]; metal-binding site
937777006489	putative 5' ssDNA interaction site; other site
937777006490	metal binding site 3; metal-binding site
937777006491	metal binding site 2 [ion binding]; metal-binding site
937777006492	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
937777006493	putative DNA binding site [nucleotide binding]; other site
937777006494	putative metal binding site [ion binding]; other site
937777006495	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
937777006496	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
937777006497	metal binding site [ion binding]; metal-binding site
937777006498	active site
937777006499	I-site; other site
937777006500	Response regulator receiver domain; Region: Response_reg; pfam00072
937777006501	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777006502	active site
937777006503	phosphorylation site [posttranslational modification]
937777006504	intermolecular recognition site; other site
937777006505	dimerization interface [polypeptide binding]; other site
937777006506	enoyl-CoA hydratase; Provisional; Region: PRK08140
937777006507	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
937777006508	substrate binding site [chemical binding]; other site
937777006509	oxyanion hole (OAH) forming residues; other site
937777006510	trimer interface [polypeptide binding]; other site
937777006511	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
937777006512	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
937777006513	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777006514	active site
937777006515	phosphorylation site [posttranslational modification]
937777006516	intermolecular recognition site; other site
937777006517	dimerization interface [polypeptide binding]; other site
937777006518	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
937777006519	DNA binding site [nucleotide binding]
937777006520	Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947
937777006521	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777006522	active site
937777006523	phosphorylation site [posttranslational modification]
937777006524	intermolecular recognition site; other site
937777006525	dimerization interface [polypeptide binding]; other site
937777006526	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
937777006527	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
937777006528	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
937777006529	dimer interface [polypeptide binding]; other site
937777006530	ssDNA binding site [nucleotide binding]; other site
937777006531	tetramer (dimer of dimers) interface [polypeptide binding]; other site
937777006532	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
937777006533	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
937777006534	dimer interface [polypeptide binding]; other site
937777006535	ssDNA binding site [nucleotide binding]; other site
937777006536	tetramer (dimer of dimers) interface [polypeptide binding]; other site
937777006537	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
937777006538	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
937777006539	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
937777006540	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
937777006541	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
937777006542	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
937777006543	active site
937777006544	metal binding site [ion binding]; metal-binding site
937777006545	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
937777006546	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
937777006547	TPP-binding site [chemical binding]; other site
937777006548	dimer interface [polypeptide binding]; other site
937777006549	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
937777006550	PYR/PP interface [polypeptide binding]; other site
937777006551	dimer interface [polypeptide binding]; other site
937777006552	TPP binding site [chemical binding]; other site
937777006553	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
937777006554	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
937777006555	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
937777006556	catalytic site [active]
937777006557	G-X2-G-X-G-K; other site
937777006558	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
937777006559	putative ADP-ribose binding site [chemical binding]; other site
937777006560	putative active site [active]
937777006561	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
937777006562	active site
937777006563	Int/Topo IB signature motif; other site
937777006564	catalytic residues [active]
937777006565	DNA binding site [nucleotide binding]
937777006566	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
937777006567	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
937777006568	dimerization interface 3.5A [polypeptide binding]; other site
937777006569	active site
937777006570	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
937777006571	nudix motif; other site
937777006572	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
937777006573	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
937777006574	NAD(P) binding site [chemical binding]; other site
937777006575	active site
937777006576	transcriptional regulator MalT; Provisional; Region: PRK04841
937777006577	Bacterial transcriptional activator domain; Region: BTAD; smart01043
937777006578	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
937777006579	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
937777006580	Esterase PHB depolymerase; Region: Esterase_phd; pfam10503
937777006581	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
937777006582	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
937777006583	Walker A/P-loop; other site
937777006584	ATP binding site [chemical binding]; other site
937777006585	Q-loop/lid; other site
937777006586	ABC transporter signature motif; other site
937777006587	Walker B; other site
937777006588	D-loop; other site
937777006589	H-loop/switch region; other site
937777006590	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
937777006591	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
937777006592	Walker A/P-loop; other site
937777006593	ATP binding site [chemical binding]; other site
937777006594	Q-loop/lid; other site
937777006595	ABC transporter signature motif; other site
937777006596	Walker B; other site
937777006597	D-loop; other site
937777006598	H-loop/switch region; other site
937777006599	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
937777006600	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
937777006601	TM-ABC transporter signature motif; other site
937777006602	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
937777006603	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
937777006604	TM-ABC transporter signature motif; other site
937777006605	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
937777006606	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
937777006607	homoserine O-acetyltransferase; Provisional; Region: PRK06765
937777006608	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
937777006609	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
937777006610	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
937777006611	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
937777006612	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
937777006613	Patatin-like phospholipase; Region: Patatin; pfam01734
937777006614	active site
937777006615	nucleophile elbow; other site
937777006616	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
937777006617	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
937777006618	TM-ABC transporter signature motif; other site
937777006619	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
937777006620	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
937777006621	TM-ABC transporter signature motif; other site
937777006622	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
937777006623	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
937777006624	Walker A/P-loop; other site
937777006625	ATP binding site [chemical binding]; other site
937777006626	Q-loop/lid; other site
937777006627	ABC transporter signature motif; other site
937777006628	Walker B; other site
937777006629	D-loop; other site
937777006630	H-loop/switch region; other site
937777006631	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
937777006632	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
937777006633	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
937777006634	putative ligand binding site [chemical binding]; other site
937777006635	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
937777006636	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
937777006637	putative NAD(P) binding site [chemical binding]; other site
937777006638	catalytic Zn binding site [ion binding]; other site
937777006639	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
937777006640	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
937777006641	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
937777006642	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
937777006643	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
937777006644	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
937777006645	active site
937777006646	catalytic residues [active]
937777006647	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
937777006648	Predicted permeases [General function prediction only]; Region: COG0795
937777006649	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
937777006650	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
937777006651	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
937777006652	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
937777006653	catalytic residues [active]
937777006654	catalytic nucleophile [active]
937777006655	Presynaptic Site I dimer interface [polypeptide binding]; other site
937777006656	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
937777006657	Synaptic Flat tetramer interface [polypeptide binding]; other site
937777006658	Synaptic Site I dimer interface [polypeptide binding]; other site
937777006659	DNA binding site [nucleotide binding]
937777006660	Recombinase; Region: Recombinase; pfam07508
937777006661	Domain of unknown function (DUF955); Region: DUF955; cl01076
937777006662	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
937777006663	non-specific DNA binding site [nucleotide binding]; other site
937777006664	salt bridge; other site
937777006665	sequence-specific DNA binding site [nucleotide binding]; other site
937777006666	RecT family; Region: RecT; cl04285
937777006667	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
937777006668	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
937777006669	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
937777006670	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14263
937777006671	MarR family; Region: MarR_2; cl17246
937777006672	VRR-NUC domain; Region: VRR_NUC; pfam08774
937777006673	Terminase small subunit; Region: Terminase_2; cl01513
937777006674	Terminase-like family; Region: Terminase_6; pfam03237
937777006675	Phage terminase large subunit; Region: Terminase_3; cl12054
937777006676	P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651
937777006677	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
937777006678	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
937777006679	active site
937777006680	catalytic triad [active]
937777006681	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
937777006682	active site
937777006683	catalytic triad [active]
937777006684	oxyanion hole [active]
937777006685	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
937777006686	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
937777006687	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
937777006688	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
937777006689	active site
937777006690	DNA binding site [nucleotide binding]
937777006691	Int/Topo IB signature motif; other site
937777006692	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
937777006693	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
937777006694	cofactor binding site; other site
937777006695	DNA binding site [nucleotide binding]
937777006696	substrate interaction site [chemical binding]; other site
937777006697	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
937777006698	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
937777006699	Competence protein; Region: Competence; pfam03772
937777006700	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
937777006701	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
937777006702	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
937777006703	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
937777006704	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
937777006705	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
937777006706	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
937777006707	AAA ATPase domain; Region: AAA_16; pfam13191
937777006708	Tetratricopeptide repeat; Region: TPR_12; pfam13424
937777006709	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
937777006710	binding surface
937777006711	TPR motif; other site
937777006712	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
937777006713	binding surface
937777006714	TPR motif; other site
937777006715	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
937777006716	S-adenosylmethionine binding site [chemical binding]; other site
937777006717	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
937777006718	binding surface
937777006719	TPR motif; other site
937777006720	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
937777006721	TPR motif; other site
937777006722	binding surface
937777006723	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
937777006724	active site
937777006725	catalytic residues [active]
937777006726	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
937777006727	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
937777006728	short chain dehydrogenase; Provisional; Region: PRK08703
937777006729	classical (c) SDRs; Region: SDR_c; cd05233
937777006730	NAD(P) binding site [chemical binding]; other site
937777006731	active site
937777006732	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
937777006733	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
937777006734	ligand binding site [chemical binding]; other site
937777006735	dimerization interface [polypeptide binding]; other site
937777006736	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
937777006737	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
937777006738	metal binding site [ion binding]; metal-binding site
937777006739	active site
937777006740	I-site; other site
937777006741	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
937777006742	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
937777006743	NlpC/P60 family; Region: NLPC_P60; pfam00877
937777006744	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
937777006745	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
937777006746	active site
937777006747	catalytic tetrad [active]
937777006748	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
937777006749	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
937777006750	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
937777006751	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
937777006752	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
937777006753	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
937777006754	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
937777006755	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
937777006756	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
937777006757	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
937777006758	Response regulator receiver domain; Region: Response_reg; pfam00072
937777006759	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777006760	active site
937777006761	phosphorylation site [posttranslational modification]
937777006762	intermolecular recognition site; other site
937777006763	dimerization interface [polypeptide binding]; other site
937777006764	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
937777006765	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
937777006766	ATP binding site [chemical binding]; other site
937777006767	putative Mg++ binding site [ion binding]; other site
937777006768	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
937777006769	nucleotide binding region [chemical binding]; other site
937777006770	ATP-binding site [chemical binding]; other site
937777006771	Fe-S metabolism associated domain; Region: SufE; cl00951
937777006772	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
937777006773	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
937777006774	active site residue [active]
937777006775	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
937777006776	active site residue [active]
937777006777	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
937777006778	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
937777006779	active site
937777006780	metal binding site [ion binding]; metal-binding site
937777006781	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
937777006782	DNA-binding site [nucleotide binding]; DNA binding site
937777006783	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
937777006784	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
937777006785	Walker A motif; other site
937777006786	ATP binding site [chemical binding]; other site
937777006787	Walker B motif; other site
937777006788	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
937777006789	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
937777006790	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
937777006791	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
937777006792	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
937777006793	Walker A motif; other site
937777006794	ATP binding site [chemical binding]; other site
937777006795	Walker B motif; other site
937777006796	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
937777006797	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
937777006798	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
937777006799	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
937777006800	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
937777006801	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
937777006802	NAD binding site [chemical binding]; other site
937777006803	homotetramer interface [polypeptide binding]; other site
937777006804	homodimer interface [polypeptide binding]; other site
937777006805	substrate binding site [chemical binding]; other site
937777006806	active site
937777006807	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777006808	PAS domain; Region: PAS_9; pfam13426
937777006809	putative active site [active]
937777006810	heme pocket [chemical binding]; other site
937777006811	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
937777006812	GAF domain; Region: GAF_3; pfam13492
937777006813	GAF domain; Region: GAF; pfam01590
937777006814	GAF domain; Region: GAF_2; pfam13185
937777006815	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777006816	putative active site [active]
937777006817	PAS fold; Region: PAS_3; pfam08447
937777006818	heme pocket [chemical binding]; other site
937777006819	PAS domain S-box; Region: sensory_box; TIGR00229
937777006820	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777006821	putative active site [active]
937777006822	heme pocket [chemical binding]; other site
937777006823	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777006824	dimer interface [polypeptide binding]; other site
937777006825	phosphorylation site [posttranslational modification]
937777006826	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777006827	ATP binding site [chemical binding]; other site
937777006828	Mg2+ binding site [ion binding]; other site
937777006829	G-X-G motif; other site
937777006830	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
937777006831	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
937777006832	Thermus thermophiles TTHB029 and similar proteins; Region: YdjC_TTHB029_like; cd10802
937777006833	putative active site [active]
937777006834	YdjC motif; other site
937777006835	Mg binding site [ion binding]; other site
937777006836	homodimer interface [polypeptide binding]; other site
937777006837	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
937777006838	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
937777006839	substrate binding pocket [chemical binding]; other site
937777006840	membrane-bound complex binding site; other site
937777006841	hinge residues; other site
937777006842	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
937777006843	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
937777006844	Walker A/P-loop; other site
937777006845	ATP binding site [chemical binding]; other site
937777006846	Q-loop/lid; other site
937777006847	ABC transporter signature motif; other site
937777006848	Walker B; other site
937777006849	D-loop; other site
937777006850	H-loop/switch region; other site
937777006851	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
937777006852	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777006853	dimer interface [polypeptide binding]; other site
937777006854	ABC-ATPase subunit interface; other site
937777006855	putative PBP binding loops; other site
937777006856	DsrE/DsrF-like family; Region: DrsE; cl00672
937777006857	putative lipid kinase; Reviewed; Region: PRK13057
937777006858	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
937777006859	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
937777006860	classical (c) SDRs; Region: SDR_c; cd05233
937777006861	NAD(P) binding site [chemical binding]; other site
937777006862	active site
937777006863	acyl-CoA synthetase; Validated; Region: PRK07788
937777006864	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
937777006865	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
937777006866	acyl-activating enzyme (AAE) consensus motif; other site
937777006867	AMP binding site [chemical binding]; other site
937777006868	active site
937777006869	CoA binding site [chemical binding]; other site
937777006870	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
937777006871	PQQ-like domain; Region: PQQ_2; pfam13360
937777006872	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
937777006873	Trp docking motif [polypeptide binding]; other site
937777006874	active site
937777006875	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
937777006876	Trp docking motif [polypeptide binding]; other site
937777006877	active site
937777006878	PQQ-like domain; Region: PQQ_2; pfam13360
937777006879	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
937777006880	Protease prsW family; Region: PrsW-protease; pfam13367
937777006881	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
937777006882	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
937777006883	active site
937777006884	catalytic tetrad [active]
937777006885	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
937777006886	CoenzymeA binding site [chemical binding]; other site
937777006887	subunit interaction site [polypeptide binding]; other site
937777006888	PHB binding site; other site
937777006889	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
937777006890	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
937777006891	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
937777006892	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
937777006893	Walker A/P-loop; other site
937777006894	ATP binding site [chemical binding]; other site
937777006895	Q-loop/lid; other site
937777006896	ABC transporter signature motif; other site
937777006897	Walker B; other site
937777006898	D-loop; other site
937777006899	H-loop/switch region; other site
937777006900	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
937777006901	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
937777006902	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
937777006903	Walker A/P-loop; other site
937777006904	ATP binding site [chemical binding]; other site
937777006905	Q-loop/lid; other site
937777006906	ABC transporter signature motif; other site
937777006907	Walker B; other site
937777006908	D-loop; other site
937777006909	H-loop/switch region; other site
937777006910	Stf0 sulphotransferase; Region: Sulphotransf; cl01835
937777006911	Major Facilitator Superfamily; Region: MFS_1; pfam07690
937777006912	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
937777006913	MarR family; Region: MarR_2; pfam12802
937777006914	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
937777006915	putative catalytic residues [active]
937777006916	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
937777006917	active site
937777006918	NTP binding site [chemical binding]; other site
937777006919	metal binding triad [ion binding]; metal-binding site
937777006920	Sporulation and spore germination; Region: Germane; cl11253
937777006921	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
937777006922	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
937777006923	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
937777006924	Uncharacterized conserved protein, YhbC family [Function unknown]; Region: COG0782
937777006925	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
937777006926	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
937777006927	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
937777006928	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
937777006929	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
937777006930	active site
937777006931	catalytic tetrad [active]
937777006932	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
937777006933	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
937777006934	catalytic residues [active]
937777006935	Transcriptional regulator [Transcription]; Region: LysR; COG0583
937777006936	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
937777006937	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
937777006938	dimerization interface [polypeptide binding]; other site
937777006939	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
937777006940	Haemolytic domain; Region: Haemolytic; cl00506
937777006941	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
937777006942	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
937777006943	putative active site [active]
937777006944	putative metal binding site [ion binding]; other site
937777006945	Predicted membrane protein [Function unknown]; Region: COG2323
937777006946	Predicted membrane protein [Function unknown]; Region: COG4325
937777006947	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
937777006948	Conserved TM helix; Region: TM_helix; pfam05552
937777006949	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
937777006950	Mechanosensitive ion channel; Region: MS_channel; pfam00924
937777006951	na(+)/h(+) antiporter; Region: c_cpa1; TIGR00844
937777006952	Erythromycin esterase; Region: Erythro_esteras; pfam05139
937777006953	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
937777006954	dimerization interface [polypeptide binding]; other site
937777006955	putative DNA binding site [nucleotide binding]; other site
937777006956	putative Zn2+ binding site [ion binding]; other site
937777006957	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
937777006958	hydrophobic ligand binding site; other site
937777006959	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
937777006960	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
937777006961	NAD(P) binding site [chemical binding]; other site
937777006962	active site
937777006963	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
937777006964	Major Facilitator Superfamily; Region: MFS_1; pfam07690
937777006965	putative substrate translocation pore; other site
937777006966	Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310
937777006967	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
937777006968	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
937777006969	Interdomain contacts; other site
937777006970	Cytokine receptor motif; other site
937777006971	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
937777006972	metal binding site [ion binding]; metal-binding site
937777006973	ligand binding site [chemical binding]; other site
937777006974	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
937777006975	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
937777006976	Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155
937777006977	Phosphotransferase enzyme family; Region: APH; pfam01636
937777006978	putative active site [active]
937777006979	putative substrate binding site [chemical binding]; other site
937777006980	ATP binding site [chemical binding]; other site
937777006981	Transcriptional regulators [Transcription]; Region: MarR; COG1846
937777006982	Flagellar regulatory protein FleQ; Region: FleQ; pfam06490
937777006983	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
937777006984	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
937777006985	DNA binding site [nucleotide binding]
937777006986	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
937777006987	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
937777006988	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
937777006989	NAD(P) binding site [chemical binding]; other site
937777006990	active site
937777006991	FOG: CBS domain [General function prediction only]; Region: COG0517
937777006992	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
937777006993	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
937777006994	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
937777006995	active site
937777006996	Zn binding site [ion binding]; other site
937777006997	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
937777006998	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
937777006999	Homeodomain-like domain; Region: HTH_32; pfam13565
937777007000	Winged helix-turn helix; Region: HTH_33; pfam13592
937777007001	DDE superfamily endonuclease; Region: DDE_3; pfam13358
937777007002	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
937777007003	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
937777007004	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
937777007005	homodimer interface [polypeptide binding]; other site
937777007006	homotetramer interface [polypeptide binding]; other site
937777007007	active site pocket [active]
937777007008	cleavage site
937777007009	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
937777007010	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
937777007011	active site
937777007012	catalytic tetrad [active]
937777007013	CHASE3 domain; Region: CHASE3; pfam05227
937777007014	HAMP domain; Region: HAMP; pfam00672
937777007015	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
937777007016	GAF domain; Region: GAF_3; pfam13492
937777007017	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
937777007018	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
937777007019	metal binding site [ion binding]; metal-binding site
937777007020	active site
937777007021	I-site; other site
937777007022	SWIM zinc finger; Region: SWIM; pfam04434
937777007023	MoxR-like ATPases [General function prediction only]; Region: COG0714
937777007024	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
937777007025	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
937777007026	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
937777007027	metal ion-dependent adhesion site (MIDAS); other site
937777007028	Predicted integral membrane protein (DUF2270); Region: DUF2270; pfam10028
937777007029	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
937777007030	PHP domain; Region: PHP; pfam02811
937777007031	active site
937777007032	PHP Thumb interface [polypeptide binding]; other site
937777007033	metal binding site [ion binding]; metal-binding site
937777007034	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
937777007035	DNA polymerase III subunit alpha; Reviewed; Region: PRK07373
937777007036	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
937777007037	generic binding surface II; other site
937777007038	generic binding surface I; other site
937777007039	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
937777007040	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
937777007041	active site
937777007042	catalytic tetrad [active]
937777007043	histidinol-phosphatase; Provisional; Region: PRK07328
937777007044	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
937777007045	active site
937777007046	dimer interface [polypeptide binding]; other site
937777007047	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
937777007048	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
937777007049	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
937777007050	IHF - DNA interface [nucleotide binding]; other site
937777007051	IHF dimer interface [polypeptide binding]; other site
937777007052	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
937777007053	Predicted amidohydrolase [General function prediction only]; Region: COG0388
937777007054	active site
937777007055	catalytic triad [active]
937777007056	dimer interface [polypeptide binding]; other site
937777007057	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
937777007058	16S/18S rRNA binding site [nucleotide binding]; other site
937777007059	S13e-L30e interaction site [polypeptide binding]; other site
937777007060	25S rRNA binding site [nucleotide binding]; other site
937777007061	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
937777007062	binding surface
937777007063	TPR motif; other site
937777007064	Tetratricopeptide repeat; Region: TPR_12; pfam13424
937777007065	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
937777007066	DNA binding site [nucleotide binding]
937777007067	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
937777007068	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
937777007069	active site
937777007070	tetramer interface [polypeptide binding]; other site
937777007071	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
937777007072	aminotransferase; Validated; Region: PRK07777
937777007073	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
937777007074	pyridoxal 5'-phosphate binding site [chemical binding]; other site
937777007075	homodimer interface [polypeptide binding]; other site
937777007076	catalytic residue [active]
937777007077	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777007078	PAS domain; Region: PAS_9; pfam13426
937777007079	putative active site [active]
937777007080	heme pocket [chemical binding]; other site
937777007081	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777007082	ATP binding site [chemical binding]; other site
937777007083	Mg2+ binding site [ion binding]; other site
937777007084	G-X-G motif; other site
937777007085	Transcriptional regulator [Transcription]; Region: PaiB; COG2808
937777007086	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
937777007087	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
937777007088	Protein of unknown function DUF45; Region: DUF45; pfam01863
937777007089	DEAD-like helicases superfamily; Region: DEXDc; smart00487
937777007090	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
937777007091	ATP binding site [chemical binding]; other site
937777007092	putative Mg++ binding site [ion binding]; other site
937777007093	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
937777007094	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
937777007095	nucleotide binding region [chemical binding]; other site
937777007096	ATP-binding site [chemical binding]; other site
937777007097	Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372
937777007098	Protein of unknown function (DUF790); Region: DUF790; pfam05626
937777007099	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
937777007100	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
937777007101	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777007102	putative active site [active]
937777007103	heme pocket [chemical binding]; other site
937777007104	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777007105	putative active site [active]
937777007106	heme pocket [chemical binding]; other site
937777007107	PAS fold; Region: PAS; pfam00989
937777007108	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
937777007109	putative active site [active]
937777007110	heme pocket [chemical binding]; other site
937777007111	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
937777007112	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777007113	active site
937777007114	phosphorylation site [posttranslational modification]
937777007115	intermolecular recognition site; other site
937777007116	dimerization interface [polypeptide binding]; other site
937777007117	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
937777007118	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
937777007119	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
937777007120	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
937777007121	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
937777007122	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
937777007123	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
937777007124	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
937777007125	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
937777007126	homodimer interface [polypeptide binding]; other site
937777007127	active site
937777007128	FMN binding site [chemical binding]; other site
937777007129	substrate binding site [chemical binding]; other site
937777007130	4Fe-4S binding domain; Region: Fer4; cl02805
937777007131	4Fe-4S binding domain; Region: Fer4; pfam00037
937777007132	phenylhydantoinase; Validated; Region: PRK08323
937777007133	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
937777007134	tetramer interface [polypeptide binding]; other site
937777007135	active site
937777007136	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
937777007137	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
937777007138	Walker A/P-loop; other site
937777007139	ATP binding site [chemical binding]; other site
937777007140	Q-loop/lid; other site
937777007141	ABC transporter signature motif; other site
937777007142	Walker B; other site
937777007143	D-loop; other site
937777007144	H-loop/switch region; other site
937777007145	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
937777007146	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777007147	dimer interface [polypeptide binding]; other site
937777007148	conserved gate region; other site
937777007149	putative PBP binding loops; other site
937777007150	ABC-ATPase subunit interface; other site
937777007151	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
937777007152	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
937777007153	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
937777007154	NMT1/THI5 like; Region: NMT1; pfam09084
937777007155	substrate binding pocket [chemical binding]; other site
937777007156	membrane-bound complex binding site; other site
937777007157	allantoate amidohydrolase; Reviewed; Region: PRK09290
937777007158	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
937777007159	active site
937777007160	metal binding site [ion binding]; metal-binding site
937777007161	dimer interface [polypeptide binding]; other site
937777007162	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
937777007163	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
937777007164	hypothetical protein; Provisional; Region: PRK06062
937777007165	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
937777007166	inhibitor-cofactor binding pocket; inhibition site
937777007167	pyridoxal 5'-phosphate binding site [chemical binding]; other site
937777007168	catalytic residue [active]
937777007169	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
937777007170	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
937777007171	tetrameric interface [polypeptide binding]; other site
937777007172	NAD binding site [chemical binding]; other site
937777007173	catalytic residues [active]
937777007174	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
937777007175	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
937777007176	non-specific DNA binding site [nucleotide binding]; other site
937777007177	salt bridge; other site
937777007178	sequence-specific DNA binding site [nucleotide binding]; other site
937777007179	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
937777007180	active site
937777007181	tetramer interface [polypeptide binding]; other site
937777007182	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
937777007183	catalytic core [active]
937777007184	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
937777007185	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
937777007186	active site
937777007187	motif I; other site
937777007188	motif II; other site
937777007189	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
937777007190	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
937777007191	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
937777007192	succinyldiaminopimelate transaminase; Validated; Region: PRK07366
937777007193	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
937777007194	pyridoxal 5'-phosphate binding site [chemical binding]; other site
937777007195	homodimer interface [polypeptide binding]; other site
937777007196	catalytic residue [active]
937777007197	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
937777007198	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
937777007199	putative binding site residues; other site
937777007200	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
937777007201	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
937777007202	homodimer interface [polypeptide binding]; other site
937777007203	Walker A motif; other site
937777007204	ATP binding site [chemical binding]; other site
937777007205	hydroxycobalamin binding site [chemical binding]; other site
937777007206	Walker B motif; other site
937777007207	High-affinity nickel-transport protein; Region: NicO; cl00964
937777007208	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
937777007209	active site
937777007210	putative homodimer interface [polypeptide binding]; other site
937777007211	SAM binding site [chemical binding]; other site
937777007212	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
937777007213	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
937777007214	putative active site [active]
937777007215	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
937777007216	putative active site [active]
937777007217	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
937777007218	Precorrin-8X methylmutase; Region: CbiC; pfam02570
937777007219	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
937777007220	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
937777007221	active site
937777007222	SAM binding site [chemical binding]; other site
937777007223	homodimer interface [polypeptide binding]; other site
937777007224	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
937777007225	active site
937777007226	SAM binding site [chemical binding]; other site
937777007227	homodimer interface [polypeptide binding]; other site
937777007228	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
937777007229	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
937777007230	cobalamin biosynthesis protein CbiG; Provisional; Region: PRK07027
937777007231	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
937777007232	active site
937777007233	SAM binding site [chemical binding]; other site
937777007234	homodimer interface [polypeptide binding]; other site
937777007235	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
937777007236	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
937777007237	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
937777007238	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
937777007239	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
937777007240	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
937777007241	dimer interface [polypeptide binding]; other site
937777007242	[2Fe-2S] cluster binding site [ion binding]; other site
937777007243	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
937777007244	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
937777007245	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
937777007246	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
937777007247	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
937777007248	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
937777007249	Walker A motif; other site
937777007250	ATP binding site [chemical binding]; other site
937777007251	Walker B motif; other site
937777007252	arginine finger; other site
937777007253	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
937777007254	metal ion-dependent adhesion site (MIDAS); other site
937777007255	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
937777007256	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
937777007257	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
937777007258	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
937777007259	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
937777007260	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
937777007261	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
937777007262	catalytic residue [active]
937777007263	cobyric acid synthase; Provisional; Region: PRK00784
937777007264	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
937777007265	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
937777007266	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
937777007267	catalytic triad [active]
937777007268	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
937777007269	homotrimer interface [polypeptide binding]; other site
937777007270	Walker A motif; other site
937777007271	GTP binding site [chemical binding]; other site
937777007272	Walker B motif; other site
937777007273	Secretory lipase; Region: LIP; pfam03583
937777007274	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
937777007275	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
937777007276	transmembrane helices; other site
937777007277	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
937777007278	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
937777007279	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
937777007280	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
937777007281	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
937777007282	Walker A/P-loop; other site
937777007283	ATP binding site [chemical binding]; other site
937777007284	Q-loop/lid; other site
937777007285	ABC transporter signature motif; other site
937777007286	Walker B; other site
937777007287	D-loop; other site
937777007288	H-loop/switch region; other site
937777007289	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
937777007290	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
937777007291	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
937777007292	Walker A/P-loop; other site
937777007293	ATP binding site [chemical binding]; other site
937777007294	Q-loop/lid; other site
937777007295	ABC transporter signature motif; other site
937777007296	Walker B; other site
937777007297	D-loop; other site
937777007298	H-loop/switch region; other site
937777007299	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
937777007300	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777007301	active site
937777007302	phosphorylation site [posttranslational modification]
937777007303	intermolecular recognition site; other site
937777007304	dimerization interface [polypeptide binding]; other site
937777007305	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
937777007306	DNA binding site [nucleotide binding]
937777007307	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
937777007308	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
937777007309	dimer interface [polypeptide binding]; other site
937777007310	phosphorylation site [posttranslational modification]
937777007311	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777007312	ATP binding site [chemical binding]; other site
937777007313	G-X-G motif; other site
937777007314	active site
937777007315	MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804
937777007316	Ferredoxin [Energy production and conversion]; Region: COG1146
937777007317	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
937777007318	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
937777007319	hinge; other site
937777007320	active site
937777007321	trigger factor; Region: tig; TIGR00115
937777007322	ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020
937777007323	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
937777007324	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
937777007325	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
937777007326	active site
937777007327	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
937777007328	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
937777007329	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
937777007330	DdrB-like protein; Region: DdrB; pfam12747
937777007331	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
937777007332	Catalytic domain of Protein Kinases; Region: PKc; cd00180
937777007333	active site
937777007334	ATP binding site [chemical binding]; other site
937777007335	substrate binding site [chemical binding]; other site
937777007336	activation loop (A-loop); other site
937777007337	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
937777007338	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
937777007339	Catalytic site [active]
937777007340	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
937777007341	Protein of unknown function (DUF503); Region: DUF503; cl00669
937777007342	Protein of unknown function (DUF1999); Region: DUF1999; pfam09390
937777007343	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
937777007344	putative active site [active]
937777007345	catalytic residue [active]
937777007346	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
937777007347	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
937777007348	oligomer interface [polypeptide binding]; other site
937777007349	active site
937777007350	metal binding site [ion binding]; metal-binding site
937777007351	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
937777007352	Nitrogen regulatory protein P-II; Region: P-II; smart00938
937777007353	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
937777007354	Archaeal/vacuolar-type H+-ATPase subunit I [Energy production and conversion]; Region: NtpI; COG1269
937777007355	ATP synthase subunit C; Region: ATP-synt_C; cl00466
937777007356	Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390
937777007357	V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074
937777007358	Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527
937777007359	V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660
937777007360	Archaeal/vacuolar-type H+-ATPase subunit F [Energy production and conversion]; Region: NtpG; COG1436
937777007361	V-type ATP synthase subunit A; Provisional; Region: PRK04192
937777007362	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
937777007363	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
937777007364	Walker A motif/ATP binding site; other site
937777007365	Walker B motif; other site
937777007366	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
937777007367	V-type ATP synthase subunit B; Provisional; Region: PRK04196
937777007368	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
937777007369	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
937777007370	Walker A motif homologous position; other site
937777007371	Walker B motif; other site
937777007372	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
937777007373	Archaeal/vacuolar-type H+-ATPase subunit D [Energy production and conversion]; Region: NtpD; COG1394
937777007374	chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214
937777007375	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
937777007376	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
937777007377	Glyco_18 domain; Region: Glyco_18; smart00636
937777007378	active site
937777007379	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
937777007380	putative hydrophobic ligand binding site [chemical binding]; other site
937777007381	MMPL family; Region: MMPL; pfam03176
937777007382	MMPL family; Region: MMPL; pfam03176
937777007383	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
937777007384	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
937777007385	metal binding site [ion binding]; metal-binding site
937777007386	active site
937777007387	I-site; other site
937777007388	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
937777007389	isopropylmalate/citramalate/homocitrate synthases; Region: LEU1_arch; TIGR02090
937777007390	active site
937777007391	catalytic residues [active]
937777007392	metal binding site [ion binding]; metal-binding site
937777007393	Helix-turn-helix domain; Region: HTH_17; pfam12728
937777007394	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102
937777007395	dimer interface [polypeptide binding]; other site
937777007396	active site
937777007397	coenzyme A binding site [chemical binding]; other site
937777007398	citrylCoA binding site [chemical binding]; other site
937777007399	Citrate synthase; Region: Citrate_synt; pfam00285
937777007400	oxalacetate/citrate binding site [chemical binding]; other site
937777007401	catalytic triad [active]
937777007402	Transcriptional regulators [Transcription]; Region: PurR; COG1609
937777007403	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
937777007404	DNA binding site [nucleotide binding]
937777007405	domain linker motif; other site
937777007406	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279
937777007407	putative dimerization interface [polypeptide binding]; other site
937777007408	putative ligand binding site [chemical binding]; other site
937777007409	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
937777007410	sugar binding site [chemical binding]; other site
937777007411	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
937777007412	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
937777007413	NAD binding site [chemical binding]; other site
937777007414	homodimer interface [polypeptide binding]; other site
937777007415	active site
937777007416	substrate binding site [chemical binding]; other site
937777007417	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
937777007418	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
937777007419	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
937777007420	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
937777007421	Peptidase family M50; Region: Peptidase_M50; pfam02163
937777007422	active site
937777007423	putative substrate binding region [chemical binding]; other site
937777007424	FOG: CBS domain [General function prediction only]; Region: COG0517
937777007425	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
937777007426	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
937777007427	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
937777007428	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
937777007429	Walker A/P-loop; other site
937777007430	ATP binding site [chemical binding]; other site
937777007431	Q-loop/lid; other site
937777007432	ABC transporter signature motif; other site
937777007433	Walker B; other site
937777007434	D-loop; other site
937777007435	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
937777007436	H-loop/switch region; other site
937777007437	motif II; other site
937777007438	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
937777007439	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
937777007440	NAD(P) binding site [chemical binding]; other site
937777007441	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
937777007442	NmrA-like family; Region: NmrA; pfam05368
937777007443	NAD(P) binding site [chemical binding]; other site
937777007444	active site
937777007445	Membrane transport protein; Region: Mem_trans; cl09117
937777007446	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
937777007447	carbohydrate binding site [chemical binding]; other site
937777007448	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
937777007449	carbohydrate binding site [chemical binding]; other site
937777007450	alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103
937777007451	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
937777007452	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
937777007453	Ca binding site [ion binding]; other site
937777007454	active site
937777007455	catalytic site [active]
937777007456	Domain of unknown function (DUF3372); Region: DUF3372; pfam11852
937777007457	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
937777007458	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
937777007459	catalytic motif [active]
937777007460	Zn binding site [ion binding]; other site
937777007461	RibD C-terminal domain; Region: RibD_C; cl17279
937777007462	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
937777007463	Lumazine binding domain; Region: Lum_binding; pfam00677
937777007464	Lumazine binding domain; Region: Lum_binding; pfam00677
937777007465	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
937777007466	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
937777007467	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
937777007468	dimerization interface [polypeptide binding]; other site
937777007469	active site
937777007470	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
937777007471	homopentamer interface [polypeptide binding]; other site
937777007472	active site
937777007473	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
937777007474	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
937777007475	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
937777007476	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
937777007477	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
937777007478	putative active site [active]
937777007479	substrate binding site [chemical binding]; other site
937777007480	putative cosubstrate binding site; other site
937777007481	catalytic site [active]
937777007482	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
937777007483	substrate binding site [chemical binding]; other site
937777007484	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
937777007485	active site
937777007486	catalytic residues [active]
937777007487	metal binding site [ion binding]; metal-binding site
937777007488	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
937777007489	Uncharacterized conserved protein [Function unknown]; Region: COG1624
937777007490	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
937777007491	DinB family; Region: DinB; cl17821
937777007492	Predicted transcriptional regulator [Transcription]; Region: COG2378
937777007493	HTH domain; Region: HTH_11; pfam08279
937777007494	WYL domain; Region: WYL; pfam13280
937777007495	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
937777007496	Roadblock/LC7 domain; Region: Robl_LC7; smart00960
937777007497	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
937777007498	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
937777007499	substrate-cofactor binding pocket; other site
937777007500	pyridoxal 5'-phosphate binding site [chemical binding]; other site
937777007501	catalytic residue [active]
937777007502	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
937777007503	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
937777007504	S-adenosylmethionine binding site [chemical binding]; other site
937777007505	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
937777007506	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
937777007507	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
937777007508	active site residue [active]
937777007509	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
937777007510	active site residue [active]
937777007511	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
937777007512	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
937777007513	S-adenosylmethionine binding site [chemical binding]; other site
937777007514	Response regulator receiver domain; Region: Response_reg; pfam00072
937777007515	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777007516	active site
937777007517	phosphorylation site [posttranslational modification]
937777007518	intermolecular recognition site; other site
937777007519	dimerization interface [polypeptide binding]; other site
937777007520	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
937777007521	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777007522	putative active site [active]
937777007523	heme pocket [chemical binding]; other site
937777007524	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777007525	dimer interface [polypeptide binding]; other site
937777007526	phosphorylation site [posttranslational modification]
937777007527	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777007528	ATP binding site [chemical binding]; other site
937777007529	Mg2+ binding site [ion binding]; other site
937777007530	G-X-G motif; other site
937777007531	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
937777007532	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
937777007533	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
937777007534	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
937777007535	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
937777007536	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
937777007537	dimerization interface [polypeptide binding]; other site
937777007538	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
937777007539	dimerization interface [polypeptide binding]; other site
937777007540	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
937777007541	dimerization interface [polypeptide binding]; other site
937777007542	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
937777007543	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
937777007544	dimerization interface [polypeptide binding]; other site
937777007545	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
937777007546	dimerization interface [polypeptide binding]; other site
937777007547	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
937777007548	dimerization interface [polypeptide binding]; other site
937777007549	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
937777007550	dimerization interface [polypeptide binding]; other site
937777007551	GAF domain; Region: GAF_2; pfam13185
937777007552	GAF domain; Region: GAF; pfam01590
937777007553	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777007554	ATP binding site [chemical binding]; other site
937777007555	Mg2+ binding site [ion binding]; other site
937777007556	G-X-G motif; other site
937777007557	Response regulator receiver domain; Region: Response_reg; pfam00072
937777007558	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777007559	active site
937777007560	phosphorylation site [posttranslational modification]
937777007561	intermolecular recognition site; other site
937777007562	Response regulator receiver domain; Region: Response_reg; pfam00072
937777007563	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777007564	active site
937777007565	phosphorylation site [posttranslational modification]
937777007566	intermolecular recognition site; other site
937777007567	dimerization interface [polypeptide binding]; other site
937777007568	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
937777007569	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777007570	active site
937777007571	phosphorylation site [posttranslational modification]
937777007572	intermolecular recognition site; other site
937777007573	dimerization interface [polypeptide binding]; other site
937777007574	Helix-turn-helix domain; Region: HTH_17; cl17695
937777007575	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
937777007576	polymerase nucleotide-binding site; other site
937777007577	DNA-binding residues [nucleotide binding]; DNA binding site
937777007578	nucleotide binding site [chemical binding]; other site
937777007579	primase nucleotide-binding site [nucleotide binding]; other site
937777007580	Domain of unknown function (DUF2357); Region: DUF2357; pfam09823
937777007581	Protein of unknown function (DUF524); Region: DUF524; pfam04411
937777007582	GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401
937777007583	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
937777007584	DNA methylase; Region: N6_N4_Mtase; pfam01555
937777007585	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
937777007586	S-adenosylmethionine binding site [chemical binding]; other site
937777007587	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
937777007588	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
937777007589	Int/Topo IB signature motif; other site
937777007590	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
937777007591	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
937777007592	nucleotide binding site [chemical binding]; other site
937777007593	N-acetyl-L-glutamate binding site [chemical binding]; other site
937777007594	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
937777007595	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
937777007596	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
937777007597	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
937777007598	FMN binding site [chemical binding]; other site
937777007599	active site
937777007600	catalytic residues [active]
937777007601	substrate binding site [chemical binding]; other site
937777007602	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
937777007603	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
937777007604	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
937777007605	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
937777007606	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
937777007607	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
937777007608	Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195
937777007609	M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896
937777007610	putative metal binding site [ion binding]; other site
937777007611	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
937777007612	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
937777007613	tetramer interface [polypeptide binding]; other site
937777007614	pyridoxal 5'-phosphate binding site [chemical binding]; other site
937777007615	catalytic residue [active]
937777007616	Predicted integral membrane protein [Function unknown]; Region: COG5637
937777007617	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
937777007618	putative hydrophobic ligand binding site [chemical binding]; other site
937777007619	Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939
937777007620	EamA-like transporter family; Region: EamA; pfam00892
937777007621	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
937777007622	EamA-like transporter family; Region: EamA; pfam00892
937777007623	RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248
937777007624	Kae1-associated kinase Bud32; Region: arch_bud32; TIGR03724
937777007625	ATP binding site [chemical binding]; other site
937777007626	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
937777007627	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354
937777007628	putative metal binding site [ion binding]; other site
937777007629	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
937777007630	catalytic core [active]
937777007631	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
937777007632	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
937777007633	tRNA; other site
937777007634	putative tRNA binding site [nucleotide binding]; other site
937777007635	putative NADP binding site [chemical binding]; other site
937777007636	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
937777007637	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
937777007638	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
937777007639	sugar binding site [chemical binding]; other site
937777007640	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
937777007641	sugar binding site [chemical binding]; other site
937777007642	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
937777007643	active site
937777007644	SAM binding site [chemical binding]; other site
937777007645	homodimer interface [polypeptide binding]; other site
937777007646	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
937777007647	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
937777007648	active site
937777007649	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
937777007650	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
937777007651	domain interfaces; other site
937777007652	active site
937777007653	Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575
937777007654	active site
937777007655	dimer interface [polypeptide binding]; other site
937777007656	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
937777007657	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
937777007658	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
937777007659	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
937777007660	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
937777007661	trimer interface [polypeptide binding]; other site
937777007662	active site
937777007663	CoA binding site [chemical binding]; other site
937777007664	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
937777007665	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
937777007666	putative active site; other site
937777007667	catalytic triad [active]
937777007668	putative dimer interface [polypeptide binding]; other site
937777007669	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
937777007670	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
937777007671	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
937777007672	Peptidase family M23; Region: Peptidase_M23; pfam01551
937777007673	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777007674	PAS fold; Region: PAS_3; pfam08447
937777007675	putative active site [active]
937777007676	heme pocket [chemical binding]; other site
937777007677	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
937777007678	GAF domain; Region: GAF; pfam01590
937777007679	PAS fold; Region: PAS_4; pfam08448
937777007680	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777007681	ATP binding site [chemical binding]; other site
937777007682	G-X-G motif; other site
937777007683	Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149
937777007684	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
937777007685	NAD(P) binding site [chemical binding]; other site
937777007686	catalytic residues [active]
937777007687	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
937777007688	classical (c) SDRs; Region: SDR_c; cd05233
937777007689	NAD(P) binding site [chemical binding]; other site
937777007690	active site
937777007691	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
937777007692	BON domain; Region: BON; pfam04972
937777007693	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
937777007694	oxidoreductase; Provisional; Region: PRK12743
937777007695	NAD(P) binding site [chemical binding]; other site
937777007696	active site
937777007697	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
937777007698	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
937777007699	active site residue [active]
937777007700	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
937777007701	active site residue [active]
937777007702	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
937777007703	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
937777007704	Multicopper oxidase; Region: Cu-oxidase; pfam00394
937777007705	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
937777007706	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
937777007707	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
937777007708	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
937777007709	fumarate hydratase; Reviewed; Region: fumC; PRK00485
937777007710	Class II fumarases; Region: Fumarase_classII; cd01362
937777007711	active site
937777007712	tetramer interface [polypeptide binding]; other site
937777007713	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
937777007714	putative active site [active]
937777007715	nucleotide binding site [chemical binding]; other site
937777007716	nudix motif; other site
937777007717	putative metal binding site [ion binding]; other site
937777007718	Tetratricopeptide repeat; Region: TPR_12; pfam13424
937777007719	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
937777007720	binding surface
937777007721	TPR motif; other site
937777007722	Tetratricopeptide repeat; Region: TPR_12; pfam13424
937777007723	Tetratricopeptide repeat; Region: TPR_12; pfam13424
937777007724	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
937777007725	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777007726	dimer interface [polypeptide binding]; other site
937777007727	phosphorylation site [posttranslational modification]
937777007728	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777007729	ATP binding site [chemical binding]; other site
937777007730	Mg2+ binding site [ion binding]; other site
937777007731	G-X-G motif; other site
937777007732	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
937777007733	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
937777007734	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
937777007735	sequence-specific DNA binding site [nucleotide binding]; other site
937777007736	salt bridge; other site
937777007737	Cupin domain; Region: Cupin_2; cl17218
937777007738	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
937777007739	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
937777007740	Coenzyme A binding pocket [chemical binding]; other site
937777007741	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
937777007742	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
937777007743	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
937777007744	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
937777007745	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
937777007746	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
937777007747	minor groove reading motif; other site
937777007748	helix-hairpin-helix signature motif; other site
937777007749	active site
937777007750	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
937777007751	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
937777007752	Predicted membrane protein [Function unknown]; Region: COG2261
937777007753	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
937777007754	S-ribosylhomocysteinase; Provisional; Region: PRK02260
937777007755	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
937777007756	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
937777007757	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
937777007758	TPR motif; other site
937777007759	Tetratricopeptide repeat; Region: TPR_12; pfam13424
937777007760	binding surface
937777007761	Tetratricopeptide repeat; Region: TPR_12; pfam13424
937777007762	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
937777007763	Zn2+ binding site [ion binding]; other site
937777007764	Mg2+ binding site [ion binding]; other site
937777007765	Predicted transcriptional regulator [Transcription]; Region: COG2932
937777007766	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
937777007767	Catalytic site [active]
937777007768	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
937777007769	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659
937777007770	active site
937777007771	DNA binding site [nucleotide binding]
937777007772	Int/Topo IB signature motif; other site
937777007773	catalytic residues [active]
937777007774	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
937777007775	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
937777007776	catalytic loop [active]
937777007777	iron binding site [ion binding]; other site
937777007778	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
937777007779	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
937777007780	active site
937777007781	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
937777007782	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
937777007783	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
937777007784	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
937777007785	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
937777007786	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
937777007787	ABC-ATPase subunit  interface; other site
937777007788	dimer interface [polypeptide binding]; other site
937777007789	putative PBP binding regions; other site
937777007790	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
937777007791	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
937777007792	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
937777007793	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
937777007794	intersubunit interface [polypeptide binding]; other site
937777007795	C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851
937777007796	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173
937777007797	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
937777007798	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
937777007799	Cu(I) binding site [ion binding]; other site
937777007800	Protein of unknown function (DUF461); Region: DUF461; pfam04314
937777007801	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
937777007802	nudix motif; other site
937777007803	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
937777007804	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
937777007805	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
937777007806	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
937777007807	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
937777007808	glycerol kinase; Provisional; Region: glpK; PRK00047
937777007809	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
937777007810	N- and C-terminal domain interface [polypeptide binding]; other site
937777007811	active site
937777007812	MgATP binding site [chemical binding]; other site
937777007813	catalytic site [active]
937777007814	metal binding site [ion binding]; metal-binding site
937777007815	glycerol binding site [chemical binding]; other site
937777007816	homotetramer interface [polypeptide binding]; other site
937777007817	homodimer interface [polypeptide binding]; other site
937777007818	FBP binding site [chemical binding]; other site
937777007819	protein IIAGlc interface [polypeptide binding]; other site
937777007820	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
937777007821	Domain of unkown function (DUF1775); Region: DUF1775; pfam07987
937777007822	Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043
937777007823	Domain of unknown function (DUF305); Region: DUF305; pfam03713
937777007824	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
937777007825	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
937777007826	N- and C-terminal domain interface [polypeptide binding]; other site
937777007827	active site
937777007828	catalytic site [active]
937777007829	metal binding site [ion binding]; metal-binding site
937777007830	carbohydrate binding site [chemical binding]; other site
937777007831	ATP binding site [chemical binding]; other site
937777007832	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
937777007833	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
937777007834	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
937777007835	putative active site [active]
937777007836	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
937777007837	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
937777007838	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
937777007839	putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198
937777007840	pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569
937777007841	active site
937777007842	bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379
937777007843	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
937777007844	active site
937777007845	nucleotide binding site [chemical binding]; other site
937777007846	HIGH motif; other site
937777007847	KMSKS motif; other site
937777007848	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
937777007849	nudix motif; other site
937777007850	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
937777007851	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
937777007852	active site
937777007853	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
937777007854	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
937777007855	active site
937777007856	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
937777007857	active site
937777007858	Zn binding site [ion binding]; other site
937777007859	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
937777007860	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
937777007861	peptide binding site [polypeptide binding]; other site
937777007862	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
937777007863	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
937777007864	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
937777007865	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
937777007866	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
937777007867	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
937777007868	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777007869	ABC-ATPase subunit interface; other site
937777007870	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
937777007871	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777007872	dimer interface [polypeptide binding]; other site
937777007873	conserved gate region; other site
937777007874	putative PBP binding loops; other site
937777007875	ABC-ATPase subunit interface; other site
937777007876	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
937777007877	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
937777007878	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
937777007879	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
937777007880	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
937777007881	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
937777007882	EamA-like transporter family; Region: EamA; pfam00892
937777007883	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
937777007884	EamA-like transporter family; Region: EamA; pfam00892
937777007885	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777007886	dimer interface [polypeptide binding]; other site
937777007887	conserved gate region; other site
937777007888	ABC-ATPase subunit interface; other site
937777007889	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
937777007890	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
937777007891	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
937777007892	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
937777007893	non-specific DNA binding site [nucleotide binding]; other site
937777007894	salt bridge; other site
937777007895	sequence-specific DNA binding site [nucleotide binding]; other site
937777007896	PBP superfamily domain; Region: PBP_like; pfam12727
937777007897	phosphodiesterase YaeI; Provisional; Region: PRK11340
937777007898	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
937777007899	putative active site [active]
937777007900	putative metal binding site [ion binding]; other site
937777007901	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
937777007902	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
937777007903	putative active site [active]
937777007904	putative metal binding site [ion binding]; other site
937777007905	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
937777007906	binding surface
937777007907	TPR motif; other site
937777007908	TPR repeat; Region: TPR_11; pfam13414
937777007909	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
937777007910	binding surface
937777007911	TPR motif; other site
937777007912	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
937777007913	active site clefts [active]
937777007914	zinc binding site [ion binding]; other site
937777007915	dimer interface [polypeptide binding]; other site
937777007916	Predicted esterase [General function prediction only]; Region: COG0627
937777007917	S-formylglutathione hydrolase; Region: PLN02442
937777007918	Colicin V production protein; Region: Colicin_V; pfam02674
937777007919	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
937777007920	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
937777007921	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
937777007922	FAD binding domain; Region: FAD_binding_4; pfam01565
937777007923	L-aspartate oxidase; Provisional; Region: PRK06175
937777007924	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
937777007925	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
937777007926	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
937777007927	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
937777007928	dimerization interface [polypeptide binding]; other site
937777007929	active site
937777007930	Quinolinate synthetase A protein; Region: NadA; pfam02445
937777007931	Predicted transcriptional regulators [Transcription]; Region: COG1695
937777007932	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
937777007933	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
937777007934	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
937777007935	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
937777007936	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
937777007937	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
937777007938	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
937777007939	substrate binding site [chemical binding]; other site
937777007940	ATP binding site [chemical binding]; other site
937777007941	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
937777007942	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
937777007943	putative DNA binding site [nucleotide binding]; other site
937777007944	putative Zn2+ binding site [ion binding]; other site
937777007945	AsnC family; Region: AsnC_trans_reg; pfam01037
937777007946	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
937777007947	EamA-like transporter family; Region: EamA; pfam00892
937777007948	EamA-like transporter family; Region: EamA; pfam00892
937777007949	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
937777007950	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
937777007951	Ribonuclease P; Region: Ribonuclease_P; pfam00825
937777007952	Haemolytic domain; Region: Haemolytic; pfam01809
937777007953	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
937777007954	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
937777007955	Protein of unknown function (DUF402); Region: DUF402; cl00979
937777007956	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
937777007957	S-adenosylmethionine binding site [chemical binding]; other site
937777007958	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
937777007959	nucleotide binding site/active site [active]
937777007960	HIT family signature motif; other site
937777007961	catalytic residue [active]
937777007962	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
937777007963	nucleotide binding site/active site [active]
937777007964	HIT family signature motif; other site
937777007965	catalytic residue [active]
937777007966	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
937777007967	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
937777007968	G-X-X-G motif; other site
937777007969	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
937777007970	RxxxH motif; other site
937777007971	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
937777007972	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
937777007973	short chain dehydrogenase; Provisional; Region: PRK07576
937777007974	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
937777007975	NAD(P) binding site [chemical binding]; other site
937777007976	substrate binding site [chemical binding]; other site
937777007977	homotetramer interface [polypeptide binding]; other site
937777007978	active site
937777007979	homodimer interface [polypeptide binding]; other site
937777007980	enoyl-CoA hydratase; Provisional; Region: PRK06142
937777007981	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
937777007982	substrate binding site [chemical binding]; other site
937777007983	oxyanion hole (OAH) forming residues; other site
937777007984	trimer interface [polypeptide binding]; other site
937777007985	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
937777007986	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
937777007987	dimer interface [polypeptide binding]; other site
937777007988	putative functional site; other site
937777007989	putative MPT binding site; other site
937777007990	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
937777007991	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
937777007992	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
937777007993	Cytochrome P450; Region: p450; cl12078
937777007994	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
937777007995	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
937777007996	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
937777007997	active site
937777007998	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
937777007999	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
937777008000	putative acyl-acceptor binding pocket; other site
937777008001	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
937777008002	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
937777008003	Protein of unknown function (DUF422); Region: DUF422; cl00991
937777008004	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
937777008005	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
937777008006	RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678
937777008007	S-adenosylmethionine synthetase; Validated; Region: PRK05250
937777008008	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
937777008009	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
937777008010	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
937777008011	Protein of unknown function (DUF418); Region: DUF418; pfam04235
937777008012	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
937777008013	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
937777008014	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
937777008015	active site
937777008016	Zn binding site [ion binding]; other site
937777008017	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
937777008018	Cupin domain; Region: Cupin_2; cl17218
937777008019	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
937777008020	AsnC family; Region: AsnC_trans_reg; pfam01037
937777008021	Ion channel; Region: Ion_trans_2; pfam07885
937777008022	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
937777008023	TrkA-N domain; Region: TrkA_N; pfam02254
937777008024	TrkA-C domain; Region: TrkA_C; pfam02080
937777008025	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
937777008026	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
937777008027	metal binding site [ion binding]; metal-binding site
937777008028	dimer interface [polypeptide binding]; other site
937777008029	recombinase A; Provisional; Region: recA; PRK09354
937777008030	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
937777008031	hexamer interface [polypeptide binding]; other site
937777008032	Walker A motif; other site
937777008033	ATP binding site [chemical binding]; other site
937777008034	Walker B motif; other site
937777008035	MOSC domain; Region: MOSC; pfam03473
937777008036	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
937777008037	sugar efflux transporter; Region: 2A0120; TIGR00899
937777008038	Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326
937777008039	SpoOM protein; Region: Spo0M; pfam07070
937777008040	FRG domain; Region: FRG; pfam08867
937777008041	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
937777008042	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
937777008043	Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962
937777008044	Methyltransferase domain; Region: Methyltransf_31; pfam13847
937777008045	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
937777008046	S-adenosylmethionine binding site [chemical binding]; other site
937777008047	hypothetical protein; Provisional; Region: PRK13665
937777008048	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
937777008049	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021
937777008050	dimer interface [polypeptide binding]; other site
937777008051	active site residues [active]
937777008052	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
937777008053	Galactose oxidase, central domain; Region: Kelch_3; cl02701
937777008054	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
937777008055	dinuclear metal binding motif [ion binding]; other site
937777008056	Domain of unknown function (DUF305); Region: DUF305; pfam03713
937777008057	pyridoxamine kinase; Validated; Region: PRK05756
937777008058	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
937777008059	dimer interface [polypeptide binding]; other site
937777008060	pyridoxal binding site [chemical binding]; other site
937777008061	ATP binding site [chemical binding]; other site
937777008062	Uncharacterized conserved protein [Function unknown]; Region: COG0432
937777008063	helicase 45; Provisional; Region: PTZ00424
937777008064	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
937777008065	ATP binding site [chemical binding]; other site
937777008066	Mg++ binding site [ion binding]; other site
937777008067	motif III; other site
937777008068	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
937777008069	nucleotide binding region [chemical binding]; other site
937777008070	ATP-binding site [chemical binding]; other site
937777008071	Domain of unknown function DUF21; Region: DUF21; pfam01595
937777008072	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
937777008073	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
937777008074	Transporter associated domain; Region: CorC_HlyC; smart01091
937777008075	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
937777008076	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663
937777008077	SxDxEG motif; other site
937777008078	active site
937777008079	metal binding site [ion binding]; metal-binding site
937777008080	homopentamer interface [polypeptide binding]; other site
937777008081	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
937777008082	Tetratricopeptide repeat; Region: TPR_12; pfam13424
937777008083	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
937777008084	binding surface
937777008085	TPR motif; other site
937777008086	Tetratricopeptide repeat; Region: TPR_12; pfam13424
937777008087	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
937777008088	binding surface
937777008089	TPR motif; other site
937777008090	Tetratricopeptide repeat; Region: TPR_12; pfam13424
937777008091	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
937777008092	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
937777008093	metal binding site [ion binding]; metal-binding site
937777008094	active site
937777008095	I-site; other site
937777008096	glycine dehydrogenase; Provisional; Region: PRK05367
937777008097	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
937777008098	tetramer interface [polypeptide binding]; other site
937777008099	pyridoxal 5'-phosphate binding site [chemical binding]; other site
937777008100	catalytic residue [active]
937777008101	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
937777008102	tetramer interface [polypeptide binding]; other site
937777008103	pyridoxal 5'-phosphate binding site [chemical binding]; other site
937777008104	catalytic residue [active]
937777008105	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
937777008106	lipoyl attachment site [posttranslational modification]; other site
937777008107	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
937777008108	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
937777008109	Transglycosylase; Region: Transgly; pfam00912
937777008110	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
937777008111	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
937777008112	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
937777008113	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
937777008114	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
937777008115	putative active site [active]
937777008116	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
937777008117	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
937777008118	active site
937777008119	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
937777008120	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
937777008121	dimer interface [polypeptide binding]; other site
937777008122	active site
937777008123	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
937777008124	dimer interface [polypeptide binding]; other site
937777008125	active site
937777008126	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
937777008127	homodimer interface [polypeptide binding]; other site
937777008128	homotetramer interface [polypeptide binding]; other site
937777008129	active site pocket [active]
937777008130	cleavage site
937777008131	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
937777008132	GAF domain; Region: GAF_2; pfam13185
937777008133	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
937777008134	GAF domain; Region: GAF; pfam01590
937777008135	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
937777008136	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
937777008137	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
937777008138	Zn2+ binding site [ion binding]; other site
937777008139	Mg2+ binding site [ion binding]; other site
937777008140	L-asparaginase II; Region: Asparaginase_II; pfam06089
937777008141	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
937777008142	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
937777008143	NAD(P) binding site [chemical binding]; other site
937777008144	active site
937777008145	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
937777008146	DNA binding site [nucleotide binding]
937777008147	active site
937777008148	DinB family; Region: DinB; cl17821
937777008149	Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427
937777008150	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
937777008151	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
937777008152	FeS/SAM binding site; other site
937777008153	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
937777008154	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
937777008155	Astacin (Peptidase family M12A); Region: Astacin; pfam01400
937777008156	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
937777008157	active site
937777008158	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
937777008159	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
937777008160	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
937777008161	metal binding site [ion binding]; metal-binding site
937777008162	active site
937777008163	I-site; other site
937777008164	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
937777008165	oligomerisation interface [polypeptide binding]; other site
937777008166	mobile loop; other site
937777008167	roof hairpin; other site
937777008168	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
937777008169	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
937777008170	ring oligomerisation interface [polypeptide binding]; other site
937777008171	ATP/Mg binding site [chemical binding]; other site
937777008172	stacking interactions; other site
937777008173	hinge regions; other site
937777008174	metal-dependent hydrolase; Provisional; Region: PRK13291
937777008175	DinB superfamily; Region: DinB_2; pfam12867
937777008176	Protein of unknown function (DUF2511); Region: DUF2511; pfam10709
937777008177	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
937777008178	heterotetramer interface [polypeptide binding]; other site
937777008179	active site pocket [active]
937777008180	cleavage site
937777008181	PAS domain S-box; Region: sensory_box; TIGR00229
937777008182	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
937777008183	putative active site [active]
937777008184	heme pocket [chemical binding]; other site
937777008185	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
937777008186	GAF domain; Region: GAF_3; pfam13492
937777008187	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777008188	dimer interface [polypeptide binding]; other site
937777008189	phosphorylation site [posttranslational modification]
937777008190	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777008191	ATP binding site [chemical binding]; other site
937777008192	G-X-G motif; other site
937777008193	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
937777008194	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
937777008195	PAAR motif; Region: PAAR_motif; cl15808
937777008196	ornithine carbamoyltransferase; Provisional; Region: PRK00779
937777008197	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
937777008198	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
937777008199	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
937777008200	GAF domain; Region: GAF; pfam01590
937777008201	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
937777008202	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
937777008203	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
937777008204	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
937777008205	metal binding site [ion binding]; metal-binding site
937777008206	active site
937777008207	I-site; other site
937777008208	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
937777008209	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
937777008210	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
937777008211	Ligand Binding Site [chemical binding]; other site
937777008212	UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085
937777008213	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
937777008214	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
937777008215	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
937777008216	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
937777008217	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
937777008218	Substrate-binding site [chemical binding]; other site
937777008219	Substrate specificity [chemical binding]; other site
937777008220	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
937777008221	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
937777008222	Substrate-binding site [chemical binding]; other site
937777008223	Substrate specificity [chemical binding]; other site
937777008224	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
937777008225	Coenzyme A binding pocket [chemical binding]; other site
937777008226	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
937777008227	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
937777008228	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
937777008229	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
937777008230	protein binding site [polypeptide binding]; other site
937777008231	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
937777008232	enoyl-CoA hydratase; Provisional; Region: PRK05995
937777008233	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
937777008234	substrate binding site [chemical binding]; other site
937777008235	oxyanion hole (OAH) forming residues; other site
937777008236	trimer interface [polypeptide binding]; other site
937777008237	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
937777008238	recombinase A; Provisional; Region: recA; PRK09354
937777008239	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
937777008240	hexamer interface [polypeptide binding]; other site
937777008241	Walker A motif; other site
937777008242	ATP binding site [chemical binding]; other site
937777008243	Walker B motif; other site
937777008244	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
937777008245	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
937777008246	competence damage-inducible protein A; Provisional; Region: PRK00549
937777008247	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
937777008248	putative MPT binding site; other site
937777008249	Competence-damaged protein; Region: CinA; cl00666
937777008250	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
937777008251	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
937777008252	Walker A/P-loop; other site
937777008253	ATP binding site [chemical binding]; other site
937777008254	Q-loop/lid; other site
937777008255	ABC transporter signature motif; other site
937777008256	Walker B; other site
937777008257	D-loop; other site
937777008258	H-loop/switch region; other site
937777008259	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
937777008260	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
937777008261	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
937777008262	tetramer interface [polypeptide binding]; other site
937777008263	pyridoxal 5'-phosphate binding site [chemical binding]; other site
937777008264	catalytic residue [active]
937777008265	CAAX protease self-immunity; Region: Abi; pfam02517
937777008266	Replication-relaxation; Region: Replic_Relax; pfam13814
937777008267	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
937777008268	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
937777008269	bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
937777008270	N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128
937777008271	substrate binding site [chemical binding]; other site
937777008272	dimer interface [polypeptide binding]; other site
937777008273	NADP binding site [chemical binding]; other site
937777008274	catalytic residues [active]
937777008275	MaoC_C  The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452
937777008276	substrate binding site [chemical binding]; other site
937777008277	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
937777008278	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
937777008279	acyl-activating enzyme (AAE) consensus motif; other site
937777008280	AMP binding site [chemical binding]; other site
937777008281	active site
937777008282	CoA binding site [chemical binding]; other site
937777008283	glutaminyl-tRNA synthetase/YqeY domain fusion protein; Provisional; Region: PRK14703
937777008284	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
937777008285	active site
937777008286	HIGH motif; other site
937777008287	nucleotide binding site [chemical binding]; other site
937777008288	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
937777008289	KMSKS motif; other site
937777008290	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
937777008291	GatB domain; Region: GatB_Yqey; smart00845
937777008292	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
937777008293	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
937777008294	tetramer interface [polypeptide binding]; other site
937777008295	heme binding pocket [chemical binding]; other site
937777008296	Transcriptional regulators [Transcription]; Region: MarR; COG1846
937777008297	MarR family; Region: MarR; pfam01047
937777008298	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
937777008299	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
937777008300	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
937777008301	DNA binding residues [nucleotide binding]
937777008302	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
937777008303	Phosphotransferase enzyme family; Region: APH; pfam01636
937777008304	active site
937777008305	ATP binding site [chemical binding]; other site
937777008306	antibiotic binding site [chemical binding]; other site
937777008307	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
937777008308	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
937777008309	active site
937777008310	catalytic residues [active]
937777008311	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
937777008312	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
937777008313	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
937777008314	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
937777008315	trmE is a tRNA modification GTPase; Region: trmE; cd04164
937777008316	G1 box; other site
937777008317	GTP/Mg2+ binding site [chemical binding]; other site
937777008318	Switch I region; other site
937777008319	G2 box; other site
937777008320	Switch II region; other site
937777008321	G3 box; other site
937777008322	G4 box; other site
937777008323	G5 box; other site
937777008324	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
937777008325	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
937777008326	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
937777008327	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
937777008328	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
937777008329	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
937777008330	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
937777008331	Walker A/P-loop; other site
937777008332	ATP binding site [chemical binding]; other site
937777008333	Q-loop/lid; other site
937777008334	ABC transporter signature motif; other site
937777008335	Walker B; other site
937777008336	D-loop; other site
937777008337	H-loop/switch region; other site
937777008338	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
937777008339	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
937777008340	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
937777008341	Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994
937777008342	Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977
937777008343	ArsC family; Region: ArsC; pfam03960
937777008344	catalytic residue [active]
937777008345	acetylornithine aminotransferase; Provisional; Region: PRK02627
937777008346	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
937777008347	inhibitor-cofactor binding pocket; inhibition site
937777008348	pyridoxal 5'-phosphate binding site [chemical binding]; other site
937777008349	catalytic residue [active]
937777008350	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
937777008351	Cupin domain; Region: Cupin_2; pfam07883
937777008352	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
937777008353	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
937777008354	DNA-binding site [nucleotide binding]; DNA binding site
937777008355	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
937777008356	pyridoxal 5'-phosphate binding site [chemical binding]; other site
937777008357	homodimer interface [polypeptide binding]; other site
937777008358	catalytic residue [active]
937777008359	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
937777008360	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
937777008361	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
937777008362	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
937777008363	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
937777008364	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
937777008365	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
937777008366	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
937777008367	Cysteine-rich domain; Region: CCG; pfam02754
937777008368	Cysteine-rich domain; Region: CCG; pfam02754
937777008369	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
937777008370	active site
937777008371	GAF domain; Region: GAF_2; pfam13185
937777008372	GAF domain; Region: GAF; pfam01590
937777008373	GAF domain; Region: GAF; pfam01590
937777008374	GAF domain; Region: GAF_2; pfam13185
937777008375	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777008376	dimer interface [polypeptide binding]; other site
937777008377	phosphorylation site [posttranslational modification]
937777008378	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777008379	ATP binding site [chemical binding]; other site
937777008380	Mg2+ binding site [ion binding]; other site
937777008381	G-X-G motif; other site
937777008382	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
937777008383	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777008384	putative active site [active]
937777008385	heme pocket [chemical binding]; other site
937777008386	GAF domain; Region: GAF; pfam01590
937777008387	Phytochrome region; Region: PHY; pfam00360
937777008388	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777008389	dimer interface [polypeptide binding]; other site
937777008390	phosphorylation site [posttranslational modification]
937777008391	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777008392	ATP binding site [chemical binding]; other site
937777008393	Mg2+ binding site [ion binding]; other site
937777008394	G-X-G motif; other site
937777008395	Response regulator receiver domain; Region: Response_reg; pfam00072
937777008396	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777008397	active site
937777008398	phosphorylation site [posttranslational modification]
937777008399	intermolecular recognition site; other site
937777008400	dimerization interface [polypeptide binding]; other site
937777008401	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
937777008402	heme binding pocket [chemical binding]; other site
937777008403	heme ligand [chemical binding]; other site
937777008404	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
937777008405	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
937777008406	Ca binding site [ion binding]; other site
937777008407	active site
937777008408	catalytic site [active]
937777008409	AAK_NAGK-UC: N-Acetyl-L-glutamate kinase - uncharacterized (NAGK-UC). This domain is similar to Escherichia coli and Pseudomonas aeruginosa NAGKs which catalyze the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the...; Region: AAK_NAGK-UC; cd04251
937777008410	putative nucleotide binding site [chemical binding]; other site
937777008411	putative N-acetyl-L-glutamate binding site [chemical binding]; other site
937777008412	GTPase RsgA; Reviewed; Region: PRK01889
937777008413	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
937777008414	GTPase/Zn-binding domain interface [polypeptide binding]; other site
937777008415	GTP/Mg2+ binding site [chemical binding]; other site
937777008416	G4 box; other site
937777008417	G5 box; other site
937777008418	G1 box; other site
937777008419	Switch I region; other site
937777008420	G2 box; other site
937777008421	G3 box; other site
937777008422	Switch II region; other site
937777008423	Protein of unknown function DUF84; Region: NTPase_I-T; cl00866
937777008424	DinB family; Region: DinB; cl17821
937777008425	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
937777008426	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
937777008427	Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144
937777008428	ATP-grasp domain; Region: ATP-grasp_4; cl17255
937777008429	lysine biosynthesis protein LysW; Region: lysW; TIGR01206
937777008430	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
937777008431	homoaconitate hydratase small subunit; Provisional; Region: PRK14023
937777008432	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
937777008433	substrate binding site [chemical binding]; other site
937777008434	metal binding sites [ion binding]; metal-binding site
937777008435	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217
937777008436	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
937777008437	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
937777008438	substrate binding site [chemical binding]; other site
937777008439	ligand binding site [chemical binding]; other site
937777008440	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
937777008441	Saccharomyces cerevisiae homocitrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_HCS; cd07948
937777008442	homocitrate synthase; Region: LysS_fung_arch; TIGR02146
937777008443	active site
937777008444	catalytic residues [active]
937777008445	metal binding site [ion binding]; metal-binding site
937777008446	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
937777008447	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
937777008448	active site
937777008449	catalytic tetrad [active]
937777008450	Subtilase family; Region: Peptidase_S8; pfam00082
937777008451	active site
937777008452	catalytic residues [active]
937777008453	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
937777008454	active site
937777008455	catalytic residues [active]
937777008456	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
937777008457	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
937777008458	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
937777008459	active site
937777008460	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
937777008461	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_long; TIGR01348
937777008462	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
937777008463	E3 interaction surface; other site
937777008464	lipoyl attachment site [posttranslational modification]; other site
937777008465	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
937777008466	E3 interaction surface; other site
937777008467	lipoyl attachment site [posttranslational modification]; other site
937777008468	e3 binding domain; Region: E3_binding; pfam02817
937777008469	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
937777008470	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
937777008471	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
937777008472	dimer interface [polypeptide binding]; other site
937777008473	TPP-binding site [chemical binding]; other site
937777008474	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
937777008475	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
937777008476	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
937777008477	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
937777008478	dimerization interface [polypeptide binding]; other site
937777008479	substrate binding pocket [chemical binding]; other site
937777008480	Kelch motif; Region: Kelch_6; pfam13964
937777008481	Galactose oxidase, central domain; Region: Kelch_3; cl02701
937777008482	Kelch motif; Region: Kelch_1; pfam01344
937777008483	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
937777008484	FOG: PKD repeat [General function prediction only]; Region: COG3291
937777008485	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
937777008486	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
937777008487	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
937777008488	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
937777008489	ATP binding site [chemical binding]; other site
937777008490	putative Mg++ binding site [ion binding]; other site
937777008491	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
937777008492	nucleotide binding region [chemical binding]; other site
937777008493	ATP-binding site [chemical binding]; other site
937777008494	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
937777008495	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
937777008496	Transcriptional regulators [Transcription]; Region: GntR; COG1802
937777008497	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
937777008498	DNA-binding site [nucleotide binding]; DNA binding site
937777008499	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
937777008500	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
937777008501	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
937777008502	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
937777008503	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
937777008504	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
937777008505	Glutamate binding site [chemical binding]; other site
937777008506	homodimer interface [polypeptide binding]; other site
937777008507	NAD binding site [chemical binding]; other site
937777008508	catalytic residues [active]
937777008509	Bacterial Ig-like domain; Region: Big_5; pfam13205
937777008510	Trehalose utilisation; Region: ThuA; pfam06283
937777008511	Kelch motif; Region: Kelch_1; pfam01344
937777008512	Galactose oxidase, central domain; Region: Kelch_3; cl02701
937777008513	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
937777008514	Kelch motif; Region: Kelch_1; pfam01344
937777008515	Galactose oxidase, central domain; Region: Kelch_3; cl02701
937777008516	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
937777008517	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
937777008518	Cu(I) binding site [ion binding]; other site
937777008519	Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250
937777008520	Kelch motif; Region: Kelch_2; pfam07646
937777008521	C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851
937777008522	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
937777008523	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
937777008524	putative ADP-binding pocket [chemical binding]; other site
937777008525	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
937777008526	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
937777008527	active site
937777008528	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
937777008529	Putative Catalytic site; other site
937777008530	DXD motif; other site
937777008531	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
937777008532	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
937777008533	Substrate binding site; other site
937777008534	Cupin domain; Region: Cupin_2; cl17218
937777008535	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
937777008536	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
937777008537	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
937777008538	putative acyl-acceptor binding pocket; other site
937777008539	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
937777008540	nucleoside/Zn binding site; other site
937777008541	dimer interface [polypeptide binding]; other site
937777008542	catalytic motif [active]
937777008543	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
937777008544	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
937777008545	metal binding site [ion binding]; metal-binding site
937777008546	active site
937777008547	I-site; other site
937777008548	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
937777008549	active site
937777008550	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
937777008551	active site
937777008552	metal binding site [ion binding]; metal-binding site
937777008553	homotetramer interface [polypeptide binding]; other site
937777008554	Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563
937777008555	AAA domain; Region: AAA_17; pfam13207
937777008556	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
937777008557	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
937777008558	Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077
937777008559	calcium binding site 2 [ion binding]; other site
937777008560	active site
937777008561	catalytic triad [active]
937777008562	calcium binding site 1 [ion binding]; other site
937777008563	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
937777008564	catalytic triad [active]
937777008565	putative active site [active]
937777008566	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
937777008567	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777008568	dimer interface [polypeptide binding]; other site
937777008569	conserved gate region; other site
937777008570	putative PBP binding loops; other site
937777008571	ABC-ATPase subunit interface; other site
937777008572	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
937777008573	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777008574	dimer interface [polypeptide binding]; other site
937777008575	conserved gate region; other site
937777008576	putative PBP binding loops; other site
937777008577	ABC-ATPase subunit interface; other site
937777008578	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
937777008579	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
937777008580	Transcriptional regulators [Transcription]; Region: PurR; COG1609
937777008581	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
937777008582	DNA binding site [nucleotide binding]
937777008583	domain linker motif; other site
937777008584	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
937777008585	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
937777008586	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
937777008587	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
937777008588	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
937777008589	conserved cys residue [active]
937777008590	maltodextrin glucosidase; Provisional; Region: PRK10785
937777008591	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
937777008592	active site
937777008593	homodimer interface [polypeptide binding]; other site
937777008594	catalytic site [active]
937777008595	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
937777008596	Major Facilitator Superfamily; Region: MFS_1; pfam07690
937777008597	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
937777008598	Domain of unknown function DUF59; Region: DUF59; cl00941
937777008599	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
937777008600	active site residue [active]
937777008601	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
937777008602	active site residue [active]
937777008603	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
937777008604	Peptidase family U32; Region: Peptidase_U32; pfam01136
937777008605	Collagenase; Region: DUF3656; pfam12392
937777008606	Quinolinate phosphoribosyl transferase, C-terminal domain; Region: QRPTase_C; pfam01729
937777008607	Peptidase family U32; Region: Peptidase_U32; cl03113
937777008608	Protein of unknown function (DUF402); Region: DUF402; cl00979
937777008609	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
937777008610	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
937777008611	active site
937777008612	metal binding site [ion binding]; metal-binding site
937777008613	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
937777008614	Transposase; Region: DEDD_Tnp_IS110; pfam01548
937777008615	DinB superfamily; Region: DinB_2; pfam12867
937777008616	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
937777008617	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
937777008618	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
937777008619	Moco binding site; other site
937777008620	metal coordination site [ion binding]; other site
937777008621	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
937777008622	active site
937777008623	SUMO-1 interface [polypeptide binding]; other site
937777008624	diaminopimelate decarboxylase; Region: lysA; TIGR01048
937777008625	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
937777008626	active site
937777008627	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
937777008628	substrate binding site [chemical binding]; other site
937777008629	catalytic residues [active]
937777008630	dimer interface [polypeptide binding]; other site
937777008631	Major Facilitator Superfamily; Region: MFS_1; pfam07690
937777008632	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
937777008633	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
937777008634	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
937777008635	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
937777008636	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
937777008637	Ligand Binding Site [chemical binding]; other site
937777008638	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
937777008639	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
937777008640	transcription elongation factor GreA; Region: greA; TIGR01462
937777008641	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
937777008642	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
937777008643	pilus retraction protein PilT; Region: pilT_fam; TIGR01420
937777008644	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
937777008645	Walker A motif; other site
937777008646	ATP binding site [chemical binding]; other site
937777008647	Walker B motif; other site
937777008648	Pantoate-beta-alanine ligase; Region: PanC; cd00560
937777008649	pantoate--beta-alanine ligase; Region: panC; TIGR00018
937777008650	active site
937777008651	ATP-binding site [chemical binding]; other site
937777008652	pantoate-binding site; other site
937777008653	HXXH motif; other site
937777008654	adenylosuccinate lyase; Provisional; Region: PRK07492
937777008655	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
937777008656	tetramer interface [polypeptide binding]; other site
937777008657	active site
937777008658	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
937777008659	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
937777008660	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
937777008661	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
937777008662	active site
937777008663	dimerization interface [polypeptide binding]; other site
937777008664	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
937777008665	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
937777008666	putative active site [active]
937777008667	Zn binding site [ion binding]; other site
937777008668	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
937777008669	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
937777008670	active site
937777008671	ATP binding site [chemical binding]; other site
937777008672	substrate binding site [chemical binding]; other site
937777008673	activation loop (A-loop); other site
937777008674	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687
937777008675	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501
937777008676	putative Iron-sulfur protein interface [polypeptide binding]; other site
937777008677	putative proximal heme binding site [chemical binding]; other site
937777008678	putative SdhD-like interface [polypeptide binding]; other site
937777008679	putative distal heme binding site [chemical binding]; other site
937777008680	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500
937777008681	putative Iron-sulfur protein interface [polypeptide binding]; other site
937777008682	putative proximal heme binding site [chemical binding]; other site
937777008683	putative SdhC-like subunit interface [polypeptide binding]; other site
937777008684	putative distal heme binding site [chemical binding]; other site
937777008685	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
937777008686	L-aspartate oxidase; Provisional; Region: PRK06175
937777008687	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
937777008688	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
937777008689	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
937777008690	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
937777008691	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
937777008692	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
937777008693	Sulfocyanin (SoxE); Region: SoxE; cl17563
937777008694	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
937777008695	Thiamine pyrophosphokinase; Region: TPK; cd07995
937777008696	active site
937777008697	dimerization interface [polypeptide binding]; other site
937777008698	thiamine binding site [chemical binding]; other site
937777008699	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
937777008700	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
937777008701	Walker A/P-loop; other site
937777008702	ATP binding site [chemical binding]; other site
937777008703	Q-loop/lid; other site
937777008704	ABC transporter signature motif; other site
937777008705	Walker B; other site
937777008706	D-loop; other site
937777008707	H-loop/switch region; other site
937777008708	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
937777008709	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777008710	dimer interface [polypeptide binding]; other site
937777008711	conserved gate region; other site
937777008712	ABC-ATPase subunit interface; other site
937777008713	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
937777008714	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
937777008715	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
937777008716	MarR family; Region: MarR; pfam01047
937777008717	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
937777008718	Major Facilitator Superfamily; Region: MFS_1; pfam07690
937777008719	putative substrate translocation pore; other site
937777008720	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
937777008721	putative substrate translocation pore; other site
937777008722	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
937777008723	GAF domain; Region: GAF_3; pfam13492
937777008724	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
937777008725	GAF domain; Region: GAF_3; pfam13492
937777008726	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777008727	dimer interface [polypeptide binding]; other site
937777008728	phosphorylation site [posttranslational modification]
937777008729	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777008730	ATP binding site [chemical binding]; other site
937777008731	Mg2+ binding site [ion binding]; other site
937777008732	G-X-G motif; other site
937777008733	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
937777008734	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
937777008735	Peptidase S8 family domain, uncharacterized subfamily 5; Region: Peptidases_S8_5; cd07489
937777008736	active site
937777008737	catalytic triad [active]
937777008738	PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818
937777008739	PA/protease or protease-like domain interface [polypeptide binding]; other site
937777008740	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
937777008741	catalytic residues [active]
937777008742	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
937777008743	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
937777008744	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
937777008745	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
937777008746	putative active site [active]
937777008747	putative substrate binding site [chemical binding]; other site
937777008748	putative cosubstrate binding site; other site
937777008749	catalytic site [active]
937777008750	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
937777008751	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
937777008752	pyridoxal 5'-phosphate binding site [chemical binding]; other site
937777008753	homodimer interface [polypeptide binding]; other site
937777008754	catalytic residue [active]
937777008755	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
937777008756	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
937777008757	5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128
937777008758	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
937777008759	hinge; other site
937777008760	active site
937777008761	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
937777008762	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
937777008763	Fe-S cluster binding site [ion binding]; other site
937777008764	DNA binding site [nucleotide binding]
937777008765	active site
937777008766	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
937777008767	elongation factor G; Reviewed; Region: PRK12740
937777008768	G1 box; other site
937777008769	putative GEF interaction site [polypeptide binding]; other site
937777008770	GTP/Mg2+ binding site [chemical binding]; other site
937777008771	Switch I region; other site
937777008772	G2 box; other site
937777008773	G3 box; other site
937777008774	Switch II region; other site
937777008775	G4 box; other site
937777008776	G5 box; other site
937777008777	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
937777008778	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
937777008779	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
937777008780	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
937777008781	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
937777008782	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
937777008783	Rhomboid family; Region: Rhomboid; cl11446
937777008784	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
937777008785	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
937777008786	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
937777008787	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
937777008788	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
937777008789	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
937777008790	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
937777008791	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
937777008792	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
937777008793	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
937777008794	homotetramer interface [polypeptide binding]; other site
937777008795	FMN binding site [chemical binding]; other site
937777008796	homodimer contacts [polypeptide binding]; other site
937777008797	putative active site [active]
937777008798	putative substrate binding site [chemical binding]; other site
937777008799	Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324
937777008800	trehalose synthase; Region: treS_nterm; TIGR02456
937777008801	active site
937777008802	catalytic site [active]
937777008803	pyruvate phosphate dikinase; Provisional; Region: PRK09279
937777008804	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
937777008805	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
937777008806	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
937777008807	Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618
937777008808	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
937777008809	homotrimer interaction site [polypeptide binding]; other site
937777008810	putative active site [active]
937777008811	prolyl-tRNA synthetase; Provisional; Region: PRK08661
937777008812	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
937777008813	dimer interface [polypeptide binding]; other site
937777008814	motif 1; other site
937777008815	active site
937777008816	motif 2; other site
937777008817	motif 3; other site
937777008818	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
937777008819	anticodon binding site; other site
937777008820	zinc-binding site [ion binding]; other site
937777008821	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
937777008822	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
937777008823	metal binding site [ion binding]; metal-binding site
937777008824	active site
937777008825	I-site; other site
937777008826	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
937777008827	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
937777008828	5S rRNA interface [nucleotide binding]; other site
937777008829	CTC domain interface [polypeptide binding]; other site
937777008830	L16 interface [polypeptide binding]; other site
937777008831	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
937777008832	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
937777008833	substrate binding site [chemical binding]; other site
937777008834	ATP binding site [chemical binding]; other site
937777008835	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
937777008836	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
937777008837	S-adenosylmethionine binding site [chemical binding]; other site
937777008838	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
937777008839	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
937777008840	TPR repeat; Region: TPR_11; pfam13414
937777008841	binding surface
937777008842	TPR motif; other site
937777008843	Uncharacterized conserved protein [Function unknown]; Region: COG0062
937777008844	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
937777008845	putative substrate binding site [chemical binding]; other site
937777008846	putative ATP binding site [chemical binding]; other site
937777008847	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
937777008848	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
937777008849	Acyl CoA binding protein; Region: ACBP; pfam00887
937777008850	acyl-CoA binding pocket [chemical binding]; other site
937777008851	CoA binding site [chemical binding]; other site
937777008852	Domain of unknown function (DUF955); Region: DUF955; cl01076
937777008853	dihydropteroate synthase; Region: DHPS; TIGR01496
937777008854	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
937777008855	substrate binding pocket [chemical binding]; other site
937777008856	dimer interface [polypeptide binding]; other site
937777008857	inhibitor binding site; inhibition site
937777008858	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
937777008859	sugar binding site [chemical binding]; other site
937777008860	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
937777008861	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
937777008862	homooctamer interface [polypeptide binding]; other site
937777008863	active site
937777008864	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
937777008865	catalytic center binding site [active]
937777008866	ATP binding site [chemical binding]; other site
937777008867	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
937777008868	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
937777008869	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
937777008870	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
937777008871	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
937777008872	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
937777008873	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
937777008874	catalytic residue [active]
937777008875	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
937777008876	active site
937777008877	catalytic residues [active]
937777008878	Domain of unknown function (DUF4396); Region: DUF4396; pfam14342
937777008879	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
937777008880	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
937777008881	metal binding site [ion binding]; metal-binding site
937777008882	active site
937777008883	I-site; other site
937777008884	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
937777008885	dimanganese center [ion binding]; other site
937777008886	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
937777008887	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
937777008888	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
937777008889	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
937777008890	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
937777008891	ATP-grasp domain; Region: ATP-grasp_4; cl17255
937777008892	argininosuccinate synthase; Provisional; Region: PRK13820
937777008893	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
937777008894	ANP binding site [chemical binding]; other site
937777008895	Substrate Binding Site II [chemical binding]; other site
937777008896	Substrate Binding Site I [chemical binding]; other site
937777008897	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
937777008898	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
937777008899	Coenzyme A binding pocket [chemical binding]; other site
937777008900	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
937777008901	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
937777008902	Coenzyme A binding pocket [chemical binding]; other site
937777008903	argininosuccinate lyase; Provisional; Region: PRK00855
937777008904	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
937777008905	active sites [active]
937777008906	tetramer interface [polypeptide binding]; other site
937777008907	putative acetyltransferase; Provisional; Region: PRK03624
937777008908	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
937777008909	Coenzyme A binding pocket [chemical binding]; other site
937777008910	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
937777008911	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
937777008912	Coenzyme A binding pocket [chemical binding]; other site
937777008913	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
937777008914	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
937777008915	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
937777008916	catalytic site [active]
937777008917	subunit interface [polypeptide binding]; other site
937777008918	Protein of unknown function (DUF3197); Region: DUF3197; pfam11432
937777008919	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
937777008920	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
937777008921	AFG1-like ATPase; Region: AFG1_ATPase; pfam03969
937777008922	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
937777008923	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
937777008924	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
937777008925	metal binding site [ion binding]; metal-binding site
937777008926	dimer interface [polypeptide binding]; other site
937777008927	Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107
937777008928	Uncharacterized conserved protein [Function unknown]; Region: COG1434
937777008929	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
937777008930	putative active site [active]
937777008931	recombination factor protein RarA; Reviewed; Region: PRK13342
937777008932	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
937777008933	Walker A motif; other site
937777008934	ATP binding site [chemical binding]; other site
937777008935	Walker B motif; other site
937777008936	arginine finger; other site
937777008937	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
937777008938	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
937777008939	active site
937777008940	ATP binding site [chemical binding]; other site
937777008941	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
937777008942	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
937777008943	active site
937777008944	substrate binding site [chemical binding]; other site
937777008945	metal binding site [ion binding]; metal-binding site
937777008946	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14323
937777008947	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
937777008948	active site
937777008949	substrate binding site [chemical binding]; other site
937777008950	metal binding site [ion binding]; metal-binding site
937777008951	Ribosome-binding factor A [Translation, ribosomal structure and biogenesis]; Region: RbfA; COG0858
937777008952	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
937777008953	active site
937777008954	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
937777008955	Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; cl01558
937777008956	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
937777008957	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
937777008958	IHF - DNA interface [nucleotide binding]; other site
937777008959	IHF dimer interface [polypeptide binding]; other site
937777008960	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
937777008961	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
937777008962	ATP binding site [chemical binding]; other site
937777008963	substrate interface [chemical binding]; other site
937777008964	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
937777008965	photosystem I assembly protein Ycf3; Provisional; Region: PRK02603
937777008966	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
937777008967	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
937777008968	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14612
937777008969	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
937777008970	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
937777008971	substrate binding site; other site
937777008972	dimer interface; other site
937777008973	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
937777008974	Flavoprotein; Region: Flavoprotein; pfam02441
937777008975	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
937777008976	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
937777008977	Walker A/P-loop; other site
937777008978	ATP binding site [chemical binding]; other site
937777008979	Q-loop/lid; other site
937777008980	ABC transporter signature motif; other site
937777008981	Walker B; other site
937777008982	D-loop; other site
937777008983	H-loop/switch region; other site
937777008984	Predicted transcriptional regulators [Transcription]; Region: COG1725
937777008985	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
937777008986	DNA-binding site [nucleotide binding]; DNA binding site
937777008987	aminoglycoside resistance protein; Provisional; Region: PRK13746
937777008988	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
937777008989	active site
937777008990	NTP binding site [chemical binding]; other site
937777008991	metal binding triad [ion binding]; metal-binding site
937777008992	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
937777008993	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314
937777008994	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
937777008995	Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935
937777008996	acyl-activating enzyme (AAE) consensus motif; other site
937777008997	putative AMP binding site [chemical binding]; other site
937777008998	putative active site [active]
937777008999	putative CoA binding site [chemical binding]; other site
937777009000	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
937777009001	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
937777009002	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
937777009003	active site
937777009004	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
937777009005	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
937777009006	active site
937777009007	metal binding site [ion binding]; metal-binding site
937777009008	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
937777009009	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
937777009010	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
937777009011	protein binding site [polypeptide binding]; other site
937777009012	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
937777009013	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
937777009014	putative dimer interface [polypeptide binding]; other site
937777009015	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
937777009016	structural tetrad; other site
937777009017	FOG: WD40 repeat [General function prediction only]; Region: COG2319
937777009018	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
937777009019	TMAO/DMSO reductase; Reviewed; Region: PRK05363
937777009020	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
937777009021	Moco binding site; other site
937777009022	metal coordination site [ion binding]; other site
937777009023	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
937777009024	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
937777009025	putative DNA binding site [nucleotide binding]; other site
937777009026	putative Zn2+ binding site [ion binding]; other site
937777009027	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
937777009028	Catalytic site [active]
937777009029	Y-family of DNA polymerases; Region: PolY; cl12025
937777009030	active site
937777009031	DNA binding site [nucleotide binding]
937777009032	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
937777009033	active site
937777009034	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
937777009035	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
937777009036	generic binding surface II; other site
937777009037	generic binding surface I; other site
937777009038	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
937777009039	multiple promoter invertase; Provisional; Region: mpi; PRK13413
937777009040	catalytic residues [active]
937777009041	catalytic nucleophile [active]
937777009042	Presynaptic Site I dimer interface [polypeptide binding]; other site
937777009043	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
937777009044	Synaptic Flat tetramer interface [polypeptide binding]; other site
937777009045	Synaptic Site I dimer interface [polypeptide binding]; other site
937777009046	DNA binding site [nucleotide binding]
937777009047	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
937777009048	Tetratricopeptide repeat; Region: TPR_12; pfam13424
937777009049	Tetratricopeptide repeat; Region: TPR_12; pfam13424
937777009050	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
937777009051	binding surface
937777009052	TPR motif; other site
937777009053	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
937777009054	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
937777009055	metal binding site [ion binding]; metal-binding site
937777009056	active site
937777009057	I-site; other site
937777009058	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
937777009059	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
937777009060	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
937777009061	putative RNA binding site [nucleotide binding]; other site
937777009062	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
937777009063	S-adenosylmethionine binding site [chemical binding]; other site
937777009064	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
937777009065	Mechanosensitive ion channel; Region: MS_channel; pfam00924
937777009066	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
937777009067	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
937777009068	ligand binding site [chemical binding]; other site
937777009069	flexible hinge region; other site
937777009070	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
937777009071	putative switch regulator; other site
937777009072	non-specific DNA interactions [nucleotide binding]; other site
937777009073	DNA binding site [nucleotide binding]
937777009074	sequence specific DNA binding site [nucleotide binding]; other site
937777009075	putative cAMP binding site [chemical binding]; other site
937777009076	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
937777009077	endonuclease III; Region: ENDO3c; smart00478
937777009078	minor groove reading motif; other site
937777009079	helix-hairpin-helix signature motif; other site
937777009080	substrate binding pocket [chemical binding]; other site
937777009081	active site
937777009082	Uncharacterized conserved protein [Function unknown]; Region: COG0398
937777009083	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
937777009084	Transcriptional regulator [Transcription]; Region: LytR; COG1316
937777009085	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
937777009086	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
937777009087	NAD(P) binding site [chemical binding]; other site
937777009088	active site
937777009089	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
937777009090	nudix motif; other site
937777009091	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
937777009092	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136
937777009093	Fe-S oxidoreductase, related to NifB/MoaA family [Energy production and conversion]; Region: COG1625
937777009094	Protein of unknown function (DUF512); Region: DUF512; pfam04459
937777009095	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
937777009096	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
937777009097	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
937777009098	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
937777009099	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
937777009100	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
937777009101	Ferredoxin [Energy production and conversion]; Region: COG1146
937777009102	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
937777009103	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
937777009104	ligand binding site [chemical binding]; other site
937777009105	flexible hinge region; other site
937777009106	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
937777009107	non-specific DNA interactions [nucleotide binding]; other site
937777009108	DNA binding site [nucleotide binding]
937777009109	sequence specific DNA binding site [nucleotide binding]; other site
937777009110	putative cAMP binding site [chemical binding]; other site
937777009111	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
937777009112	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
937777009113	active site
937777009114	metal binding site [ion binding]; metal-binding site
937777009115	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
937777009116	ADP-ribose binding site [chemical binding]; other site
937777009117	dimer interface [polypeptide binding]; other site
937777009118	active site
937777009119	nudix motif; other site
937777009120	metal binding site [ion binding]; metal-binding site
937777009121	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
937777009122	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
937777009123	active site
937777009124	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934
937777009125	OstA-like protein; Region: OstA; cl00844
937777009126	aspartate aminotransferase; Provisional; Region: PRK05764
937777009127	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
937777009128	pyridoxal 5'-phosphate binding site [chemical binding]; other site
937777009129	homodimer interface [polypeptide binding]; other site
937777009130	catalytic residue [active]
937777009131	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
937777009132	active site
937777009133	multimer interface [polypeptide binding]; other site
937777009134	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
937777009135	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
937777009136	TM-ABC transporter signature motif; other site
937777009137	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
937777009138	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
937777009139	TM-ABC transporter signature motif; other site
937777009140	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
937777009141	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
937777009142	non-specific DNA binding site [nucleotide binding]; other site
937777009143	salt bridge; other site
937777009144	sequence-specific DNA binding site [nucleotide binding]; other site
937777009145	PEGA domain; Region: PEGA; pfam08308
937777009146	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
937777009147	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
937777009148	Domain of unknown function DUF20; Region: UPF0118; pfam01594
937777009149	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
937777009150	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
937777009151	active site
937777009152	metal binding site [ion binding]; metal-binding site
937777009153	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
937777009154	active site
937777009155	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
937777009156	catalytic tetrad [active]
937777009157	Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253
937777009158	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
937777009159	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
937777009160	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
937777009161	Uncharacterized conserved protein [Function unknown]; Region: COG2947
937777009162	Thymidylate synthase complementing protein; Region: Thy1; cl03630
937777009163	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
937777009164	gamma-glutamyl kinase; Provisional; Region: PRK05429
937777009165	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
937777009166	nucleotide binding site [chemical binding]; other site
937777009167	homotetrameric interface [polypeptide binding]; other site
937777009168	putative phosphate binding site [ion binding]; other site
937777009169	putative allosteric binding site; other site
937777009170	PUA domain; Region: PUA; pfam01472
937777009171	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
937777009172	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
937777009173	putative catalytic cysteine [active]
937777009174	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
937777009175	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
937777009176	catalytic residues [active]
937777009177	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
937777009178	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
937777009179	putative ADP-binding pocket [chemical binding]; other site
937777009180	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
937777009181	S17 interaction site [polypeptide binding]; other site
937777009182	S8 interaction site; other site
937777009183	16S rRNA interaction site [nucleotide binding]; other site
937777009184	streptomycin interaction site [chemical binding]; other site
937777009185	23S rRNA interaction site [nucleotide binding]; other site
937777009186	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
937777009187	30S ribosomal protein S7; Validated; Region: PRK05302
937777009188	elongation factor G; Reviewed; Region: PRK00007
937777009189	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
937777009190	G1 box; other site
937777009191	putative GEF interaction site [polypeptide binding]; other site
937777009192	GTP/Mg2+ binding site [chemical binding]; other site
937777009193	Switch I region; other site
937777009194	G2 box; other site
937777009195	G3 box; other site
937777009196	Switch II region; other site
937777009197	G4 box; other site
937777009198	G5 box; other site
937777009199	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
937777009200	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
937777009201	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
937777009202	elongation factor Tu; Reviewed; Region: PRK00049
937777009203	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
937777009204	G1 box; other site
937777009205	GEF interaction site [polypeptide binding]; other site
937777009206	GTP/Mg2+ binding site [chemical binding]; other site
937777009207	Switch I region; other site
937777009208	G2 box; other site
937777009209	G3 box; other site
937777009210	Switch II region; other site
937777009211	G4 box; other site
937777009212	G5 box; other site
937777009213	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
937777009214	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
937777009215	Antibiotic Binding Site [chemical binding]; other site
937777009216	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
937777009217	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
937777009218	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
937777009219	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
937777009220	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
937777009221	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
937777009222	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
937777009223	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
937777009224	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
937777009225	putative translocon binding site; other site
937777009226	protein-rRNA interface [nucleotide binding]; other site
937777009227	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
937777009228	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
937777009229	G-X-X-G motif; other site
937777009230	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
937777009231	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
937777009232	23S rRNA interface [nucleotide binding]; other site
937777009233	5S rRNA interface [nucleotide binding]; other site
937777009234	putative antibiotic binding site [chemical binding]; other site
937777009235	L25 interface [polypeptide binding]; other site
937777009236	L27 interface [polypeptide binding]; other site
937777009237	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
937777009238	23S rRNA interface [nucleotide binding]; other site
937777009239	putative translocon interaction site; other site
937777009240	signal recognition particle (SRP54) interaction site; other site
937777009241	L23 interface [polypeptide binding]; other site
937777009242	trigger factor interaction site; other site
937777009243	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
937777009244	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
937777009245	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
937777009246	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
937777009247	RNA binding site [nucleotide binding]; other site
937777009248	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
937777009249	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
937777009250	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
937777009251	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
937777009252	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
937777009253	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
937777009254	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
937777009255	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
937777009256	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
937777009257	5S rRNA interface [nucleotide binding]; other site
937777009258	23S rRNA interface [nucleotide binding]; other site
937777009259	L5 interface [polypeptide binding]; other site
937777009260	ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021
937777009261	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
937777009262	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
937777009263	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
937777009264	23S rRNA binding site [nucleotide binding]; other site
937777009265	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
937777009266	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
937777009267	SecY translocase; Region: SecY; pfam00344
937777009268	adenylate kinase; Provisional; Region: PRK14527
937777009269	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
937777009270	AMP-binding site [chemical binding]; other site
937777009271	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
937777009272	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
937777009273	rRNA binding site [nucleotide binding]; other site
937777009274	predicted 30S ribosome binding site; other site
937777009275	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
937777009276	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
937777009277	30S ribosomal protein S13; Region: bact_S13; TIGR03631
937777009278	30S ribosomal protein S11; Validated; Region: PRK05309
937777009279	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
937777009280	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
937777009281	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
937777009282	RNA binding surface [nucleotide binding]; other site
937777009283	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
937777009284	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
937777009285	alphaNTD - beta interaction site [polypeptide binding]; other site
937777009286	alphaNTD homodimer interface [polypeptide binding]; other site
937777009287	alphaNTD - beta' interaction site [polypeptide binding]; other site
937777009288	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
937777009289	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
937777009290	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
937777009291	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
937777009292	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
937777009293	catalytic residues [active]
937777009294	Domain of unknown function (DUF309); Region: DUF309; pfam03745
937777009295	Uncharacterized conserved protein [Function unknown]; Region: COG1432
937777009296	LabA_like proteins; Region: LabA; cd10911
937777009297	putative metal binding site [ion binding]; other site
937777009298	envelope glycoprotein E; Provisional; Region: PHA03281
937777009299	putative phosphate acyltransferase; Provisional; Region: PRK05331
937777009300	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
937777009301	Mechanosensitive ion channel; Region: MS_channel; pfam00924
937777009302	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
937777009303	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
937777009304	Walker A motif; other site
937777009305	ATP binding site [chemical binding]; other site
937777009306	Walker B motif; other site
937777009307	arginine finger; other site
937777009308	Peptidase family M41; Region: Peptidase_M41; pfam01434
937777009309	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
937777009310	metal-dependent hydrolase; Provisional; Region: PRK13291
937777009311	DinB superfamily; Region: DinB_2; pfam12867
937777009312	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
937777009313	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
937777009314	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
937777009315	FeS/SAM binding site; other site
937777009316	Predicted permeases [General function prediction only]; Region: COG0679
937777009317	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
937777009318	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
937777009319	dimer interface [polypeptide binding]; other site
937777009320	active site
937777009321	CoA binding pocket [chemical binding]; other site
937777009322	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
937777009323	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777009324	active site
937777009325	phosphorylation site [posttranslational modification]
937777009326	intermolecular recognition site; other site
937777009327	dimerization interface [polypeptide binding]; other site
937777009328	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
937777009329	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777009330	active site
937777009331	phosphorylation site [posttranslational modification]
937777009332	intermolecular recognition site; other site
937777009333	dimerization interface [polypeptide binding]; other site
937777009334	Response regulator receiver domain; Region: Response_reg; pfam00072
937777009335	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777009336	active site
937777009337	phosphorylation site [posttranslational modification]
937777009338	intermolecular recognition site; other site
937777009339	dimerization interface [polypeptide binding]; other site
937777009340	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_8; cd06905
937777009341	putative active site [active]
937777009342	Zn binding site [ion binding]; other site
937777009343	hypothetical protein; Provisional; Region: PRK04233
937777009344	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
937777009345	Part of AAA domain; Region: AAA_19; pfam13245
937777009346	Family description; Region: UvrD_C_2; pfam13538
937777009347	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
937777009348	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
937777009349	CHAP domain; Region: CHAP; cl17642
937777009350	arginine decarboxylase; Provisional; Region: PRK05354
937777009351	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
937777009352	dimer interface [polypeptide binding]; other site
937777009353	active site
937777009354	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
937777009355	catalytic residues [active]
937777009356	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
937777009357	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
937777009358	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
937777009359	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK14662
937777009360	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
937777009361	active site
937777009362	NTP binding site [chemical binding]; other site
937777009363	metal binding triad [ion binding]; metal-binding site
937777009364	antibiotic binding site [chemical binding]; other site
937777009365	Uncharacterized conserved protein [Function unknown]; Region: COG2361
937777009366	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
937777009367	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
937777009368	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
937777009369	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
937777009370	putative active site [active]
937777009371	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
937777009372	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
937777009373	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
937777009374	metal binding site [ion binding]; metal-binding site
937777009375	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
937777009376	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
937777009377	substrate binding site [chemical binding]; other site
937777009378	glutamase interaction surface [polypeptide binding]; other site
937777009379	Response regulator receiver domain; Region: Response_reg; pfam00072
937777009380	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777009381	active site
937777009382	phosphorylation site [posttranslational modification]
937777009383	intermolecular recognition site; other site
937777009384	dimerization interface [polypeptide binding]; other site
937777009385	Uncharacterized conserved protein [Function unknown]; Region: COG1801
937777009386	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
937777009387	Moco binding site; other site
937777009388	metal coordination site [ion binding]; other site
937777009389	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
937777009390	Methyltransferase domain; Region: Methyltransf_23; pfam13489
937777009391	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
937777009392	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
937777009393	MutS domain I; Region: MutS_I; pfam01624
937777009394	MutS domain II; Region: MutS_II; pfam05188
937777009395	MutS domain III; Region: MutS_III; pfam05192
937777009396	MutS domain V; Region: MutS_V; pfam00488
937777009397	Walker A/P-loop; other site
937777009398	ATP binding site [chemical binding]; other site
937777009399	Q-loop/lid; other site
937777009400	ABC transporter signature motif; other site
937777009401	Walker B; other site
937777009402	D-loop; other site
937777009403	H-loop/switch region; other site
937777009404	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
937777009405	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777009406	ATP binding site [chemical binding]; other site
937777009407	Mg2+ binding site [ion binding]; other site
937777009408	G-X-G motif; other site
937777009409	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
937777009410	ATP binding site [chemical binding]; other site
937777009411	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
937777009412	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
937777009413	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
937777009414	malonyl-CoA binding site [chemical binding]; other site
937777009415	dimer interface [polypeptide binding]; other site
937777009416	active site
937777009417	product binding site; other site
937777009418	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227
937777009419	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
937777009420	S-adenosylmethionine binding site [chemical binding]; other site
937777009421	FAD binding domain; Region: FAD_binding_3; pfam01494
937777009422	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
937777009423	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
937777009424	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
937777009425	active site
937777009426	catalytic site [active]
937777009427	metal binding site [ion binding]; metal-binding site
937777009428	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
937777009429	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
937777009430	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
937777009431	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777009432	putative PBP binding loops; other site
937777009433	ABC-ATPase subunit interface; other site
937777009434	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
937777009435	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777009436	dimer interface [polypeptide binding]; other site
937777009437	conserved gate region; other site
937777009438	putative PBP binding loops; other site
937777009439	ABC-ATPase subunit interface; other site
937777009440	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
937777009441	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
937777009442	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
937777009443	Walker A/P-loop; other site
937777009444	ATP binding site [chemical binding]; other site
937777009445	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
937777009446	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
937777009447	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
937777009448	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
937777009449	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
937777009450	thymidine kinase; Provisional; Region: PRK04296
937777009451	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
937777009452	DEAD-like helicases superfamily; Region: DEXDc; smart00487
937777009453	ATP binding site [chemical binding]; other site
937777009454	Mg++ binding site [ion binding]; other site
937777009455	motif III; other site
937777009456	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
937777009457	nucleotide binding region [chemical binding]; other site
937777009458	ATP-binding site [chemical binding]; other site
937777009459	RNA-binding GUCT domain found in the RNA helicase II/Gu protein family; Region: GUCT; cl06960
937777009460	Predicted transcriptional regulators [Transcription]; Region: COG1733
937777009461	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
937777009462	NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370
937777009463	dimer interface [polypeptide binding]; other site
937777009464	FMN binding site [chemical binding]; other site
937777009465	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
937777009466	metal binding site 2 [ion binding]; metal-binding site
937777009467	putative DNA binding helix; other site
937777009468	metal binding site 1 [ion binding]; metal-binding site
937777009469	dimer interface [polypeptide binding]; other site
937777009470	structural Zn2+ binding site [ion binding]; other site
937777009471	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
937777009472	S-adenosylmethionine binding site [chemical binding]; other site
937777009473	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
937777009474	active site lid residues [active]
937777009475	substrate binding pocket [chemical binding]; other site
937777009476	catalytic residues [active]
937777009477	substrate-Mg2+ binding site; other site
937777009478	aspartate-rich region 1; other site
937777009479	aspartate-rich region 2; other site
937777009480	phytoene desaturase; Region: crtI_fam; TIGR02734
937777009481	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
937777009482	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
937777009483	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
937777009484	putative NAD(P) binding site [chemical binding]; other site
937777009485	active site
937777009486	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
937777009487	CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918
937777009488	ligand binding site [chemical binding]; other site
937777009489	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
937777009490	putative switch regulator; other site
937777009491	non-specific DNA interactions [nucleotide binding]; other site
937777009492	DNA binding site [nucleotide binding]
937777009493	sequence specific DNA binding site [nucleotide binding]; other site
937777009494	putative cAMP binding site [chemical binding]; other site
937777009495	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
937777009496	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
937777009497	DNA binding residues [nucleotide binding]
937777009498	B12 binding domain; Region: B12-binding_2; pfam02607
937777009499	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065
937777009500	B12 binding site [chemical binding]; other site
937777009501	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
937777009502	active site
937777009503	catalytic residues [active]
937777009504	metal binding site [ion binding]; metal-binding site
937777009505	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
937777009506	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
937777009507	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
937777009508	Recombination protein O C terminal; Region: RecO_C; pfam02565
937777009509	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
937777009510	Uncharacterized conserved protein, YhbC family [Function unknown]; Region: COG0782
937777009511	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
937777009512	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
937777009513	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
937777009514	dimer interface [polypeptide binding]; other site
937777009515	putative anticodon binding site; other site
937777009516	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
937777009517	motif 1; other site
937777009518	active site
937777009519	motif 2; other site
937777009520	motif 3; other site
937777009521	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
937777009522	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
937777009523	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
937777009524	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
937777009525	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
937777009526	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777009527	putative PBP binding loops; other site
937777009528	ABC-ATPase subunit interface; other site
937777009529	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
937777009530	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777009531	dimer interface [polypeptide binding]; other site
937777009532	conserved gate region; other site
937777009533	putative PBP binding loops; other site
937777009534	ABC-ATPase subunit interface; other site
937777009535	Tthb094 and related proteins, classical (c) SDRs; Region: Tthb094_like_SDR_c; cd11730
937777009536	NAD(P) binding site [chemical binding]; other site
937777009537	putative active site [active]
937777009538	Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14603
937777009539	RuvA N terminal domain; Region: RuvA_N; pfam01330
937777009540	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
937777009541	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
937777009542	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
937777009543	Catalytic site [active]
937777009544	DNA polymerase I; Provisional; Region: PRK05755
937777009545	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
937777009546	active site
937777009547	metal binding site 1 [ion binding]; metal-binding site
937777009548	putative 5' ssDNA interaction site; other site
937777009549	metal binding site 3; metal-binding site
937777009550	metal binding site 2 [ion binding]; metal-binding site
937777009551	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
937777009552	putative DNA binding site [nucleotide binding]; other site
937777009553	putative metal binding site [ion binding]; other site
937777009554	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
937777009555	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
937777009556	active site
937777009557	DNA binding site [nucleotide binding]
937777009558	catalytic site [active]
937777009559	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
937777009560	dimerization interface [polypeptide binding]; other site
937777009561	Protein of unknown function (DUF2847); Region: DUF2847; pfam11009
937777009562	glycogen synthase; Provisional; Region: glgA; PRK00654
937777009563	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
937777009564	ADP-binding pocket [chemical binding]; other site
937777009565	homodimer interface [polypeptide binding]; other site
937777009566	CheB methylesterase; Region: CheB_methylest; pfam01339
937777009567	CheB methylesterase; Region: CheB_methylest; pfam01339
937777009568	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
937777009569	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
937777009570	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
937777009571	PAS domain; Region: PAS_10; pfam13596
937777009572	PAS fold; Region: PAS_4; pfam08448
937777009573	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777009574	dimer interface [polypeptide binding]; other site
937777009575	phosphorylation site [posttranslational modification]
937777009576	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777009577	ATP binding site [chemical binding]; other site
937777009578	Mg2+ binding site [ion binding]; other site
937777009579	G-X-G motif; other site
937777009580	CheB methylesterase; Region: CheB_methylest; pfam01339
937777009581	MarR family; Region: MarR_2; cl17246
937777009582	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
937777009583	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
937777009584	catalytic triad [active]
937777009585	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
937777009586	Cytochrome P450; Region: p450; cl12078
937777009587	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
937777009588	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
937777009589	ATP binding site [chemical binding]; other site
937777009590	putative Mg++ binding site [ion binding]; other site
937777009591	nucleotide binding region [chemical binding]; other site
937777009592	helicase superfamily c-terminal domain; Region: HELICc; smart00490
937777009593	Helicase associated domain (HA2); Region: HA2; pfam04408
937777009594	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
937777009595	Uncharacterized conserved protein [Function unknown]; Region: COG2127
937777009596	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
937777009597	Clp amino terminal domain; Region: Clp_N; pfam02861
937777009598	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
937777009599	Walker A motif; other site
937777009600	ATP binding site [chemical binding]; other site
937777009601	Walker B motif; other site
937777009602	arginine finger; other site
937777009603	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
937777009604	Walker A motif; other site
937777009605	ATP binding site [chemical binding]; other site
937777009606	Walker B motif; other site
937777009607	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
937777009608	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
937777009609	Nitronate monooxygenase; Region: NMO; pfam03060
937777009610	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
937777009611	FMN binding site [chemical binding]; other site
937777009612	substrate binding site [chemical binding]; other site
937777009613	putative catalytic residue [active]
937777009614	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
937777009615	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
937777009616	homodimer interface [polypeptide binding]; other site
937777009617	substrate-cofactor binding pocket; other site
937777009618	pyridoxal 5'-phosphate binding site [chemical binding]; other site
937777009619	catalytic residue [active]
937777009620	Peptidase family M48; Region: Peptidase_M48; cl12018
937777009621	Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987
937777009622	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
937777009623	active site
937777009624	Ap6A binding site [chemical binding]; other site
937777009625	nudix motif; other site
937777009626	metal binding site [ion binding]; metal-binding site
937777009627	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
937777009628	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
937777009629	trimer interface [polypeptide binding]; other site
937777009630	putative metal binding site [ion binding]; other site
937777009631	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
937777009632	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
937777009633	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
937777009634	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
937777009635	NPCBM/NEW2 domain; Region: NPCBM; pfam08305
937777009636	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
937777009637	Bacterial Ig-like domain; Region: Big_5; pfam13205
937777009638	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
937777009639	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
937777009640	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
937777009641	active site
937777009642	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
937777009643	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
937777009644	putative active site [active]
937777009645	putative metal binding site [ion binding]; other site
937777009646	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
937777009647	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
937777009648	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
937777009649	active site
937777009650	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
937777009651	Ligand binding site [chemical binding]; other site
937777009652	Electron transfer flavoprotein domain; Region: ETF; pfam01012
937777009653	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
937777009654	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
937777009655	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
937777009656	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
937777009657	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
937777009658	Zn2+ binding site [ion binding]; other site
937777009659	Mg2+ binding site [ion binding]; other site
937777009660	Phosphotransferase enzyme family; Region: APH; pfam01636
937777009661	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
937777009662	active site
937777009663	substrate binding site [chemical binding]; other site
937777009664	ATP binding site [chemical binding]; other site
937777009665	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
937777009666	active site
937777009667	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
937777009668	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
937777009669	Mg++ binding site [ion binding]; other site
937777009670	putative catalytic motif [active]
937777009671	substrate binding site [chemical binding]; other site
937777009672	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
937777009673	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
937777009674	active site
937777009675	homodimer interface [polypeptide binding]; other site
937777009676	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
937777009677	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
937777009678	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
937777009679	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
937777009680	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
937777009681	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
937777009682	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
937777009683	TPR motif; other site
937777009684	binding surface
937777009685	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
937777009686	malate synthase A; Region: malate_syn_A; TIGR01344
937777009687	active site
937777009688	isocitrate lyase; Provisional; Region: PRK15063
937777009689	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
937777009690	tetramer interface [polypeptide binding]; other site
937777009691	active site
937777009692	Mg2+/Mn2+ binding site [ion binding]; other site
937777009693	Bacterial Ig-like domain; Region: Big_5; pfam13205
937777009694	Bacterial Ig-like domain; Region: Big_5; pfam13205
937777009695	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
937777009696	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
937777009697	Domain of unknown function DUF20; Region: UPF0118; pfam01594
937777009698	Protein of unknown function (DUF1517); Region: DUF1517; cl01807
937777009699	PAS fold; Region: PAS; pfam00989
937777009700	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777009701	putative active site [active]
937777009702	heme pocket [chemical binding]; other site
937777009703	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
937777009704	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
937777009705	Walker A motif; other site
937777009706	ATP binding site [chemical binding]; other site
937777009707	Walker B motif; other site
937777009708	arginine finger; other site
937777009709	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
937777009710	Walker A motif; other site
937777009711	ATP binding site [chemical binding]; other site
937777009712	Walker B motif; other site
937777009713	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
937777009714	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
937777009715	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
937777009716	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
937777009717	putative ligand binding site [chemical binding]; other site
937777009718	NAD binding site [chemical binding]; other site
937777009719	catalytic site [active]
937777009720	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
937777009721	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
937777009722	NAD(P) binding site [chemical binding]; other site
937777009723	active site
937777009724	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
937777009725	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
937777009726	inhibitor site; inhibition site
937777009727	active site
937777009728	dimer interface [polypeptide binding]; other site
937777009729	catalytic residue [active]
937777009730	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
937777009731	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
937777009732	active site
937777009733	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
937777009734	CoA-transferase family III; Region: CoA_transf_3; pfam02515
937777009735	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
937777009736	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
937777009737	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
937777009738	Predicted dehydrogenase [General function prediction only]; Region: COG0579
937777009739	hydroxyglutarate oxidase; Provisional; Region: PRK11728
937777009740	Transcriptional regulators [Transcription]; Region: FadR; COG2186
937777009741	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
937777009742	DNA-binding site [nucleotide binding]; DNA binding site
937777009743	FCD domain; Region: FCD; pfam07729
937777009744	Lipocalin-like domain; Region: Lipocalin_5; pfam13924
937777009745	chaperone protein DnaJ; Provisional; Region: PRK14299
937777009746	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
937777009747	HSP70 interaction site [polypeptide binding]; other site
937777009748	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
937777009749	substrate binding site [polypeptide binding]; other site
937777009750	dimer interface [polypeptide binding]; other site
937777009751	GrpE; Region: GrpE; pfam01025
937777009752	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
937777009753	dimer interface [polypeptide binding]; other site
937777009754	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
937777009755	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
937777009756	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
937777009757	nucleotide binding site [chemical binding]; other site
937777009758	NEF interaction site [polypeptide binding]; other site
937777009759	SBD interface [polypeptide binding]; other site
937777009760	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
937777009761	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
937777009762	Walker A motif; other site
937777009763	ATP binding site [chemical binding]; other site
937777009764	Walker B motif; other site
937777009765	arginine finger; other site
937777009766	Peptidase family M41; Region: Peptidase_M41; pfam01434
937777009767	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
937777009768	putative substrate translocation pore; other site
937777009769	Major Facilitator Superfamily; Region: MFS_1; pfam07690
937777009770	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
937777009771	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
937777009772	Walker A/P-loop; other site
937777009773	ATP binding site [chemical binding]; other site
937777009774	Q-loop/lid; other site
937777009775	ABC transporter signature motif; other site
937777009776	Walker B; other site
937777009777	D-loop; other site
937777009778	H-loop/switch region; other site
937777009779	thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277
937777009780	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
937777009781	Walker A/P-loop; other site
937777009782	ATP binding site [chemical binding]; other site
937777009783	Q-loop/lid; other site
937777009784	ABC transporter signature motif; other site
937777009785	Walker B; other site
937777009786	D-loop; other site
937777009787	H-loop/switch region; other site
937777009788	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
937777009789	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
937777009790	substrate binding site [chemical binding]; other site
937777009791	oxyanion hole (OAH) forming residues; other site
937777009792	trimer interface [polypeptide binding]; other site
937777009793	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
937777009794	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
937777009795	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
937777009796	active site
937777009797	motif I; other site
937777009798	motif II; other site
937777009799	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
937777009800	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
937777009801	multifunctional aminopeptidase A; Provisional; Region: PRK00913
937777009802	interface (dimer of trimers) [polypeptide binding]; other site
937777009803	Substrate-binding/catalytic site; other site
937777009804	Zn-binding sites [ion binding]; other site
937777009805	seryl-tRNA synthetase; Provisional; Region: PRK05431
937777009806	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
937777009807	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
937777009808	dimer interface [polypeptide binding]; other site
937777009809	active site
937777009810	motif 1; other site
937777009811	motif 2; other site
937777009812	motif 3; other site
937777009813	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
937777009814	tyrosine decarboxylase; Region: PLN02880
937777009815	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
937777009816	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
937777009817	catalytic residue [active]
937777009818	Helix-turn-helix domain; Region: HTH_17; pfam12728
937777009819	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
937777009820	Cytochrome P450; Region: p450; cl12078
937777009821	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
937777009822	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
937777009823	substrate binding pocket [chemical binding]; other site
937777009824	chain length determination region; other site
937777009825	substrate-Mg2+ binding site; other site
937777009826	catalytic residues [active]
937777009827	aspartate-rich region 1; other site
937777009828	active site lid residues [active]
937777009829	aspartate-rich region 2; other site
937777009830	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
937777009831	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
937777009832	dimerization interface [polypeptide binding]; other site
937777009833	putative ATP binding site [chemical binding]; other site
937777009834	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
937777009835	catalytic core [active]
937777009836	membrane ATPase/protein kinase; Provisional; Region: PRK09435
937777009837	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
937777009838	Walker A; other site
937777009839	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
937777009840	homodimer interface [polypeptide binding]; other site
937777009841	substrate-cofactor binding pocket; other site
937777009842	Aminotransferase class IV; Region: Aminotran_4; pfam01063
937777009843	pyridoxal 5'-phosphate binding site [chemical binding]; other site
937777009844	catalytic residue [active]
937777009845	anthranilate synthase component I, archaeal clade; Region: TrpE-arch; TIGR01820
937777009846	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
937777009847	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
937777009848	Glutamine amidotransferase class-I; Region: GATase; pfam00117
937777009849	glutamine binding [chemical binding]; other site
937777009850	catalytic triad [active]
937777009851	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
937777009852	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777009853	active site
937777009854	phosphorylation site [posttranslational modification]
937777009855	intermolecular recognition site; other site
937777009856	dimerization interface [polypeptide binding]; other site
937777009857	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
937777009858	DNA binding residues [nucleotide binding]
937777009859	dimerization interface [polypeptide binding]; other site
937777009860	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
937777009861	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
937777009862	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
937777009863	GAF domain; Region: GAF_3; pfam13492
937777009864	GAF domain; Region: GAF_2; pfam13185
937777009865	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777009866	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
937777009867	putative active site [active]
937777009868	heme pocket [chemical binding]; other site
937777009869	Histidine kinase; Region: HisKA_3; pfam07730
937777009870	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777009871	ATP binding site [chemical binding]; other site
937777009872	Mg2+ binding site [ion binding]; other site
937777009873	G-X-G motif; other site
937777009874	LrgB-like family; Region: LrgB; cl00596
937777009875	LrgA family; Region: LrgA; pfam03788
937777009876	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
937777009877	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
937777009878	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
937777009879	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
937777009880	pyridoxal 5'-phosphate binding site [chemical binding]; other site
937777009881	homodimer interface [polypeptide binding]; other site
937777009882	catalytic residue [active]
937777009883	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
937777009884	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846
937777009885	putative homodimer interface [polypeptide binding]; other site
937777009886	putative homotetramer interface [polypeptide binding]; other site
937777009887	putative allosteric switch controlling residues; other site
937777009888	putative metal binding site [ion binding]; other site
937777009889	putative homodimer-homodimer interface [polypeptide binding]; other site
937777009890	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
937777009891	metal-binding site [ion binding]
937777009892	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
937777009893	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
937777009894	metal-binding site [ion binding]
937777009895	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
937777009896	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
937777009897	metal-binding site [ion binding]
937777009898	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
937777009899	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
937777009900	motif II; other site
937777009901	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
937777009902	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
937777009903	dimer interface [polypeptide binding]; other site
937777009904	pyridoxal 5'-phosphate binding site [chemical binding]; other site
937777009905	catalytic residue [active]
937777009906	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
937777009907	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
937777009908	active site
937777009909	metal binding site [ion binding]; metal-binding site
937777009910	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
937777009911	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
937777009912	HflX GTPase family; Region: HflX; cd01878
937777009913	G1 box; other site
937777009914	GTP/Mg2+ binding site [chemical binding]; other site
937777009915	Switch I region; other site
937777009916	G2 box; other site
937777009917	G3 box; other site
937777009918	Switch II region; other site
937777009919	G4 box; other site
937777009920	G5 box; other site
937777009921	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
937777009922	MviN-like protein; Region: MVIN; pfam03023
937777009923	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
937777009924	putative active site [active]
937777009925	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
937777009926	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
937777009927	homodimer interface [polypeptide binding]; other site
937777009928	substrate-cofactor binding pocket; other site
937777009929	catalytic residue [active]
937777009930	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
937777009931	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
937777009932	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
937777009933	protein binding site [polypeptide binding]; other site
937777009934	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
937777009935	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
937777009936	active site
937777009937	interdomain interaction site; other site
937777009938	putative metal-binding site [ion binding]; other site
937777009939	nucleotide binding site [chemical binding]; other site
937777009940	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
937777009941	domain I; other site
937777009942	DNA binding groove [nucleotide binding]
937777009943	phosphate binding site [ion binding]; other site
937777009944	domain II; other site
937777009945	domain III; other site
937777009946	nucleotide binding site [chemical binding]; other site
937777009947	catalytic site [active]
937777009948	domain IV; other site
937777009949	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
937777009950	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
937777009951	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
937777009952	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
937777009953	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
937777009954	FeS/SAM binding site; other site
937777009955	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
937777009956	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
937777009957	FMN binding site [chemical binding]; other site
937777009958	active site
937777009959	catalytic residues [active]
937777009960	substrate binding site [chemical binding]; other site
937777009961	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
937777009962	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
937777009963	oligomer interface [polypeptide binding]; other site
937777009964	active site
937777009965	metal binding site [ion binding]; metal-binding site
937777009966	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
937777009967	GAF domain; Region: GAF_2; pfam13185
937777009968	GAF domain; Region: GAF_3; pfam13492
937777009969	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
937777009970	Histidine kinase; Region: HisKA_3; pfam07730
937777009971	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777009972	ATP binding site [chemical binding]; other site
937777009973	Mg2+ binding site [ion binding]; other site
937777009974	G-X-G motif; other site
937777009975	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
937777009976	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
937777009977	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
937777009978	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
937777009979	putative RNA binding site [nucleotide binding]; other site
937777009980	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
937777009981	Glucose inhibited division protein A; Region: GIDA; pfam01134
937777009982	Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; cl01558
937777009983	Predicted metalloprotease [General function prediction only]; Region: COG2321
937777009984	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
937777009985	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
937777009986	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
937777009987	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
937777009988	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
937777009989	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
937777009990	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
937777009991	putative active site [active]
937777009992	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
937777009993	glycyl-tRNA synthetase; Provisional; Region: PRK04173
937777009994	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
937777009995	motif 1; other site
937777009996	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
937777009997	active site
937777009998	motif 2; other site
937777009999	motif 3; other site
937777010000	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
937777010001	anticodon binding site; other site
937777010002	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
937777010003	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
937777010004	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
937777010005	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
937777010006	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
937777010007	Coenzyme A binding pocket [chemical binding]; other site
937777010008	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
937777010009	Coenzyme A binding pocket [chemical binding]; other site
937777010010	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
937777010011	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
937777010012	active site
937777010013	HIGH motif; other site
937777010014	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
937777010015	KMSKS motif; other site
937777010016	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
937777010017	tRNA binding surface [nucleotide binding]; other site
937777010018	anticodon binding site; other site
937777010019	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
937777010020	CHRD domain; Region: CHRD; pfam07452
937777010021	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
937777010022	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777010023	Mg2+ binding site [ion binding]; other site
937777010024	G-X-G motif; other site
937777010025	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
937777010026	anchoring element; other site
937777010027	dimer interface [polypeptide binding]; other site
937777010028	ATP binding site [chemical binding]; other site
937777010029	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
937777010030	active site
937777010031	putative metal-binding site [ion binding]; other site
937777010032	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
937777010033	tRNA pseudouridine synthase B; Provisional; Region: PRK14122
937777010034	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
937777010035	RNA binding site [nucleotide binding]; other site
937777010036	active site
937777010037	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
937777010038	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
937777010039	RNA binding surface [nucleotide binding]; other site
937777010040	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
937777010041	active site
937777010042	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
937777010043	MraZ protein; Region: MraZ; pfam02381
937777010044	MraZ protein; Region: MraZ; pfam02381
937777010045	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
937777010046	MraW methylase family; Region: Methyltransf_5; cl17771
937777010047	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
937777010048	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
937777010049	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
937777010050	3D domain; Region: 3D; cl01439
937777010051	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
937777010052	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
937777010053	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
937777010054	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
937777010055	putative active site [active]
937777010056	metal binding site [ion binding]; metal-binding site
937777010057	homodimer binding site [polypeptide binding]; other site
937777010058	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
937777010059	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
937777010060	Uncharacterized conserved protein [Function unknown]; Region: COG1432
937777010061	LabA_like proteins; Region: LabA; cd10911
937777010062	putative metal binding site [ion binding]; other site
937777010063	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
937777010064	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
937777010065	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
937777010066	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
937777010067	active site
937777010068	Zn binding site [ion binding]; other site
937777010069	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
937777010070	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777010071	ATP binding site [chemical binding]; other site
937777010072	Mg2+ binding site [ion binding]; other site
937777010073	G-X-G motif; other site
937777010074	NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; Region: NuoA; COG0838
937777010075	NADH dehydrogenase subunit B; Validated; Region: PRK06411
937777010076	NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852
937777010077	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
937777010078	NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962
937777010079	NADH dehydrogenase subunit D; Validated; Region: PRK06075
937777010080	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
937777010081	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
937777010082	putative dimer interface [polypeptide binding]; other site
937777010083	[2Fe-2S] cluster binding site [ion binding]; other site
937777010084	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
937777010085	SLBB domain; Region: SLBB; pfam10531
937777010086	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
937777010087	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
937777010088	NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973
937777010089	catalytic loop [active]
937777010090	iron binding site [ion binding]; other site
937777010091	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
937777010092	MopB_NADH-Q-OR-NuoG2: The NuoG/Nad11/75-kDa subunit (second domain) of the NADH-quinone oxidoreductase (NADH-Q-OR)/respiratory complex I/NADH dehydrogenase-1 (NDH-1). The NADH-Q-OR is the first energy-transducting complex in the respiratory chains of...; Region: MopB_NADH-Q-OR-NuoG2; cd02768
937777010093	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
937777010094	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
937777010095	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
937777010096	4Fe-4S binding domain; Region: Fer4; pfam00037
937777010097	4Fe-4S binding domain; Region: Fer4; pfam00037
937777010098	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
937777010099	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
937777010100	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
937777010101	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
937777010102	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
937777010103	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
937777010104	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
937777010105	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
937777010106	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
937777010107	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
937777010108	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
937777010109	Walker A/P-loop; other site
937777010110	ATP binding site [chemical binding]; other site
937777010111	Q-loop/lid; other site
937777010112	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
937777010113	ABC transporter signature motif; other site
937777010114	Walker B; other site
937777010115	D-loop; other site
937777010116	ABC transporter; Region: ABC_tran_2; pfam12848
937777010117	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
937777010118	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
937777010119	DHH family; Region: DHH; pfam01368
937777010120	DHHA1 domain; Region: DHHA1; pfam02272
937777010121	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
937777010122	Protein export membrane protein; Region: SecD_SecF; cl14618
937777010123	Protein export membrane protein; Region: SecD_SecF; pfam02355
937777010124	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
937777010125	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
937777010126	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
937777010127	G1 box; other site
937777010128	putative GEF interaction site [polypeptide binding]; other site
937777010129	GTP/Mg2+ binding site [chemical binding]; other site
937777010130	Switch I region; other site
937777010131	G2 box; other site
937777010132	G3 box; other site
937777010133	Switch II region; other site
937777010134	G4 box; other site
937777010135	G5 box; other site
937777010136	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
937777010137	Translation-initiation factor 2; Region: IF-2; pfam11987
937777010138	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
937777010139	Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740
937777010140	putative RNA binding cleft [nucleotide binding]; other site
937777010141	transcription termination factor NusA; Region: NusA; TIGR01953
937777010142	NusA N-terminal domain; Region: NusA_N; pfam08529
937777010143	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
937777010144	RNA binding site [nucleotide binding]; other site
937777010145	homodimer interface [polypeptide binding]; other site
937777010146	NusA-like KH domain; Region: KH_5; pfam13184
937777010147	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
937777010148	G-X-X-G motif; other site
937777010149	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779
937777010150	Sm and related proteins; Region: Sm_like; cl00259
937777010151	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
937777010152	putative oligomer interface [polypeptide binding]; other site
937777010153	putative RNA binding site [nucleotide binding]; other site
937777010154	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
937777010155	general stress protein 13; Validated; Region: PRK08059
937777010156	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
937777010157	RNA binding site [nucleotide binding]; other site
937777010158	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
937777010159	active site
937777010160	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
937777010161	active site
937777010162	ribulose/triose binding site [chemical binding]; other site
937777010163	phosphate binding site [ion binding]; other site
937777010164	substrate (anthranilate) binding pocket [chemical binding]; other site
937777010165	product (indole) binding pocket [chemical binding]; other site
937777010166	Ion transport protein; Region: Ion_trans; pfam00520
937777010167	Ion channel; Region: Ion_trans_2; pfam07885
937777010168	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
937777010169	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
937777010170	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
937777010171	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
937777010172	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
937777010173	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
937777010174	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
937777010175	Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
937777010176	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
937777010177	active site
937777010178	PrcB C-terminal; Region: PrcB_C; pfam14343
937777010179	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
937777010180	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
937777010181	Walker A/P-loop; other site
937777010182	ATP binding site [chemical binding]; other site
937777010183	Q-loop/lid; other site
937777010184	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
937777010185	ABC transporter signature motif; other site
937777010186	Walker B; other site
937777010187	D-loop; other site
937777010188	H-loop/switch region; other site
937777010189	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
937777010190	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
937777010191	metal binding site [ion binding]; metal-binding site
937777010192	substrate binding pocket [chemical binding]; other site
937777010193	aconitate hydratase; Validated; Region: PRK09277
937777010194	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
937777010195	substrate binding site [chemical binding]; other site
937777010196	ligand binding site [chemical binding]; other site
937777010197	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
937777010198	substrate binding site [chemical binding]; other site
937777010199	Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720
937777010200	VanW like protein; Region: VanW; pfam04294
937777010201	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
937777010202	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
937777010203	active site
937777010204	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
937777010205	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
937777010206	ligand binding site [chemical binding]; other site
937777010207	flexible hinge region; other site
937777010208	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
937777010209	non-specific DNA interactions [nucleotide binding]; other site
937777010210	DNA binding site [nucleotide binding]
937777010211	sequence specific DNA binding site [nucleotide binding]; other site
937777010212	putative cAMP binding site [chemical binding]; other site
937777010213	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
937777010214	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
937777010215	Walker A/P-loop; other site
937777010216	ATP binding site [chemical binding]; other site
937777010217	Q-loop/lid; other site
937777010218	ABC transporter signature motif; other site
937777010219	Walker B; other site
937777010220	D-loop; other site
937777010221	H-loop/switch region; other site
937777010222	S-layer homology domain; Region: SLH; pfam00395
937777010223	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
937777010224	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
937777010225	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
937777010226	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
937777010227	substrate binding site [chemical binding]; other site
937777010228	oxyanion hole (OAH) forming residues; other site
937777010229	trimer interface [polypeptide binding]; other site
937777010230	HD supefamily hydrolase [General function prediction only]; Region: COG3294
937777010231	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680
937777010232	bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379
937777010233	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
937777010234	active site
937777010235	nucleotide binding site [chemical binding]; other site
937777010236	HIGH motif; other site
937777010237	KMSKS motif; other site
937777010238	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
937777010239	nudix motif; other site
937777010240	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
937777010241	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
937777010242	active site
937777010243	benzoate transport; Region: 2A0115; TIGR00895
937777010244	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
937777010245	putative substrate translocation pore; other site
937777010246	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
937777010247	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
937777010248	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
937777010249	homodimer interface [polypeptide binding]; other site
937777010250	NAD binding pocket [chemical binding]; other site
937777010251	ATP binding pocket [chemical binding]; other site
937777010252	Mg binding site [ion binding]; other site
937777010253	active-site loop [active]
937777010254	RNHCP domain; Region: RNHCP; pfam12647
937777010255	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
937777010256	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
937777010257	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
937777010258	active site
937777010259	substrate binding site [chemical binding]; other site
937777010260	cosubstrate binding site; other site
937777010261	catalytic site [active]
937777010262	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
937777010263	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
937777010264	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
937777010265	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
937777010266	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
937777010267	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
937777010268	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
937777010269	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777010270	dimer interface [polypeptide binding]; other site
937777010271	conserved gate region; other site
937777010272	putative PBP binding loops; other site
937777010273	ABC-ATPase subunit interface; other site
937777010274	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
937777010275	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
937777010276	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777010277	dimer interface [polypeptide binding]; other site
937777010278	conserved gate region; other site
937777010279	putative PBP binding loops; other site
937777010280	ABC-ATPase subunit interface; other site
937777010281	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
937777010282	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
937777010283	Walker A/P-loop; other site
937777010284	ATP binding site [chemical binding]; other site
937777010285	Q-loop/lid; other site
937777010286	ABC transporter signature motif; other site
937777010287	Walker B; other site
937777010288	D-loop; other site
937777010289	H-loop/switch region; other site
937777010290	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
937777010291	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
937777010292	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
937777010293	Walker A/P-loop; other site
937777010294	ATP binding site [chemical binding]; other site
937777010295	Q-loop/lid; other site
937777010296	ABC transporter signature motif; other site
937777010297	Walker B; other site
937777010298	D-loop; other site
937777010299	H-loop/switch region; other site
937777010300	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
937777010301	Uncharacterized conserved protein [Function unknown]; Region: COG5316
937777010302	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
937777010303	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
937777010304	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
937777010305	active site
937777010306	substrate binding site [chemical binding]; other site
937777010307	coenzyme B12 binding site [chemical binding]; other site
937777010308	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
937777010309	B12 binding site [chemical binding]; other site
937777010310	cobalt ligand [ion binding]; other site
937777010311	membrane ATPase/protein kinase; Provisional; Region: PRK09435
937777010312	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
937777010313	Walker A; other site
937777010314	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
937777010315	nucleotide binding site/active site [active]
937777010316	HIT family signature motif; other site
937777010317	catalytic residue [active]
937777010318	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
937777010319	classical (c) SDRs; Region: SDR_c; cd05233
937777010320	NAD(P) binding site [chemical binding]; other site
937777010321	active site
937777010322	Creatinine amidohydrolase; Region: Creatininase; pfam02633
937777010323	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
937777010324	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
937777010325	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
937777010326	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
937777010327	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
937777010328	dimerization interface [polypeptide binding]; other site
937777010329	putative DNA binding site [nucleotide binding]; other site
937777010330	putative Zn2+ binding site [ion binding]; other site
937777010331	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
937777010332	Low molecular weight phosphatase family; Region: LMWPc; cd00115
937777010333	active site
937777010334	arsenical pump membrane protein; Provisional; Region: PRK15445
937777010335	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
937777010336	transmembrane helices; other site
937777010337	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
937777010338	classical (c) SDRs; Region: SDR_c; cd05233
937777010339	NAD(P) binding site [chemical binding]; other site
937777010340	active site
937777010341	hypothetical protein; Provisional; Region: PRK14013
937777010342	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
937777010343	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777010344	dimer interface [polypeptide binding]; other site
937777010345	conserved gate region; other site
937777010346	putative PBP binding loops; other site
937777010347	ABC-ATPase subunit interface; other site
937777010348	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
937777010349	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777010350	dimer interface [polypeptide binding]; other site
937777010351	conserved gate region; other site
937777010352	putative PBP binding loops; other site
937777010353	ABC-ATPase subunit interface; other site
937777010354	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
937777010355	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
937777010356	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
937777010357	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
937777010358	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
937777010359	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
937777010360	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
937777010361	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
937777010362	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
937777010363	CTP synthetase; Validated; Region: pyrG; PRK05380
937777010364	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
937777010365	Catalytic site [active]
937777010366	active site
937777010367	UTP binding site [chemical binding]; other site
937777010368	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
937777010369	active site
937777010370	putative oxyanion hole; other site
937777010371	catalytic triad [active]
937777010372	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
937777010373	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
937777010374	CoA-binding site [chemical binding]; other site
937777010375	ATP-binding [chemical binding]; other site
937777010376	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
937777010377	binding surface
937777010378	Tetratricopeptide repeat; Region: TPR_16; pfam13432
937777010379	TPR motif; other site
937777010380	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
937777010381	TPR motif; other site
937777010382	TPR repeat; Region: TPR_11; pfam13414
937777010383	binding surface
937777010384	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
937777010385	binding surface
937777010386	TPR motif; other site
937777010387	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
937777010388	TPR motif; other site
937777010389	binding surface
937777010390	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
937777010391	rRNA interaction site [nucleotide binding]; other site
937777010392	S8 interaction site; other site
937777010393	putative laminin-1 binding site; other site
937777010394	elongation factor Ts; Provisional; Region: tsf; PRK09377
937777010395	UBA/TS-N domain; Region: UBA; pfam00627
937777010396	Elongation factor TS; Region: EF_TS; pfam00889
937777010397	Elongation factor TS; Region: EF_TS; pfam00889
937777010398	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
937777010399	putative nucleotide binding site [chemical binding]; other site
937777010400	uridine monophosphate binding site [chemical binding]; other site
937777010401	homohexameric interface [polypeptide binding]; other site
937777010402	ribosome recycling factor; Reviewed; Region: frr; PRK00083
937777010403	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
937777010404	hinge region; other site
937777010405	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
937777010406	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
937777010407	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
937777010408	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
937777010409	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
937777010410	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
937777010411	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
937777010412	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
937777010413	active site
937777010414	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
937777010415	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
937777010416	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
937777010417	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
937777010418	Ligand binding site; other site
937777010419	Putative Catalytic site; other site
937777010420	DXD motif; other site
937777010421	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
937777010422	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
937777010423	active site
937777010424	substrate binding site [chemical binding]; other site
937777010425	Mg2+ binding site [ion binding]; other site
937777010426	Flagellin N-methylase; Region: FliB; cl00497
937777010427	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
937777010428	4Fe-4S binding domain; Region: Fer4; pfam00037
937777010429	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
937777010430	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
937777010431	glutamate racemase; Provisional; Region: PRK00865
937777010432	ribonuclease PH; Reviewed; Region: rph; PRK00173
937777010433	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
937777010434	oligomer interface [polypeptide binding]; other site
937777010435	RNA binding site [nucleotide binding]; other site
937777010436	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
937777010437	active site
937777010438	dimerization interface [polypeptide binding]; other site
937777010439	peptide chain release factor 2; Validated; Region: prfB; PRK00578
937777010440	PCRF domain; Region: PCRF; pfam03462
937777010441	RF-1 domain; Region: RF-1; pfam00472
937777010442	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
937777010443	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
937777010444	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
937777010445	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
937777010446	dimer interface [polypeptide binding]; other site
937777010447	active site
937777010448	glycine-pyridoxal phosphate binding site [chemical binding]; other site
937777010449	folate binding site [chemical binding]; other site
937777010450	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
937777010451	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
937777010452	GAF domain; Region: GAF; cl17456
937777010453	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
937777010454	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
937777010455	metal binding site [ion binding]; metal-binding site
937777010456	active site
937777010457	I-site; other site
937777010458	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
937777010459	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
937777010460	RNA methyltransferase, RsmE family; Region: TIGR00046
937777010461	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217
937777010462	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
937777010463	FAD binding domain; Region: FAD_binding_4; pfam01565
937777010464	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
937777010465	active site
937777010466	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
937777010467	active site
937777010468	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
937777010469	Predicted dehydrogenase [General function prediction only]; Region: COG5322
937777010470	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
937777010471	NAD(P) binding pocket [chemical binding]; other site
937777010472	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
937777010473	Acyltransferase family; Region: Acyl_transf_3; pfam01757
937777010474	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
937777010475	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
937777010476	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
937777010477	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
937777010478	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
937777010479	GTP binding site; other site
937777010480	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
937777010481	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
937777010482	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
937777010483	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
937777010484	putative dimer interface [polypeptide binding]; other site
937777010485	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
937777010486	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
937777010487	active site
937777010488	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
937777010489	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
937777010490	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
937777010491	dihydroorotase; Validated; Region: pyrC; PRK09357
937777010492	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
937777010493	active site
937777010494	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
937777010495	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
937777010496	quinone interaction residues [chemical binding]; other site
937777010497	active site
937777010498	catalytic residues [active]
937777010499	FMN binding site [chemical binding]; other site
937777010500	substrate binding site [chemical binding]; other site
937777010501	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
937777010502	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
937777010503	Transcriptional regulator; Region: Rrf2; cl17282
937777010504	Rrf2 family protein; Region: rrf2_super; TIGR00738
937777010505	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
937777010506	dimer interface [polypeptide binding]; other site
937777010507	active site
937777010508	Schiff base residues; other site
937777010509	Protein kinase domain; Region: Pkinase; pfam00069
937777010510	Catalytic domain of Protein Kinases; Region: PKc; cd00180
937777010511	active site
937777010512	ATP binding site [chemical binding]; other site
937777010513	substrate binding site [chemical binding]; other site
937777010514	activation loop (A-loop); other site
937777010515	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
937777010516	DNA polymerase III, delta subunit; Region: holA; TIGR01128
937777010517	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
937777010518	Protein of unknown function (DUF3208); Region: DUF3208; pfam11482
937777010519	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
937777010520	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
937777010521	motif II; other site
937777010522	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
937777010523	DHH family; Region: DHH; pfam01368
937777010524	HerA helicase [Replication, recombination, and repair]; Region: COG0433
937777010525	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2380
937777010526	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
937777010527	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
937777010528	Ligand Binding Site [chemical binding]; other site
937777010529	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
937777010530	AAA domain; Region: AAA_30; pfam13604
937777010531	Family description; Region: UvrD_C_2; pfam13538
937777010532	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
937777010533	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
937777010534	active site
937777010535	metal binding site [ion binding]; metal-binding site
937777010536	DNA binding site [nucleotide binding]
937777010537	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
937777010538	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
937777010539	Walker A/P-loop; other site
937777010540	ATP binding site [chemical binding]; other site
937777010541	Q-loop/lid; other site
937777010542	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
937777010543	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
937777010544	Q-loop/lid; other site
937777010545	ABC transporter signature motif; other site
937777010546	Walker B; other site
937777010547	D-loop; other site
937777010548	H-loop/switch region; other site
937777010549	PQQ-like domain; Region: PQQ_2; pfam13360
937777010550	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
937777010551	Trp docking motif [polypeptide binding]; other site
937777010552	active site
937777010553	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
937777010554	glycogen branching enzyme; Provisional; Region: PRK14706
937777010555	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
937777010556	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
937777010557	active site
937777010558	catalytic site [active]
937777010559	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
937777010560	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181
937777010561	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
937777010562	putative active site [active]
937777010563	oxyanion strand; other site
937777010564	catalytic triad [active]
937777010565	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
937777010566	putative active site pocket [active]
937777010567	4-fold oligomerization interface [polypeptide binding]; other site
937777010568	metal binding residues [ion binding]; metal-binding site
937777010569	3-fold/trimer interface [polypeptide binding]; other site
937777010570	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
937777010571	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
937777010572	aspartate racemase; Region: asp_race; TIGR00035
937777010573	methionine sulfoxide reductase A; Provisional; Region: PRK14054
937777010574	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
937777010575	MOSC domain; Region: MOSC; pfam03473
937777010576	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
937777010577	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
937777010578	Sulfate transporter family; Region: Sulfate_transp; pfam00916
937777010579	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
937777010580	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
937777010581	sugar binding site [chemical binding]; other site
937777010582	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
937777010583	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
937777010584	putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308
937777010585	amidase; Provisional; Region: PRK06828
937777010586	Amidase; Region: Amidase; cl11426
937777010587	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
937777010588	Prephenate dehydratase; Region: PDT; pfam00800
937777010589	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
937777010590	putative L-Phe binding site [chemical binding]; other site
937777010591	putative transposase OrfB; Reviewed; Region: PHA02517
937777010592	HTH-like domain; Region: HTH_21; pfam13276
937777010593	Integrase core domain; Region: rve; pfam00665
937777010594	Integrase core domain; Region: rve_3; pfam13683
937777010595	Transposase; Region: HTH_Tnp_1; pfam01527
937777010596	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
937777010597	PAS domain; Region: PAS_9; pfam13426
937777010598	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
937777010599	PAS domain; Region: PAS_9; pfam13426
937777010600	putative active site [active]
937777010601	heme pocket [chemical binding]; other site
937777010602	DoxX-like family; Region: DoxX_2; pfam13564
937777010603	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
937777010604	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
937777010605	putative metal binding site [ion binding]; other site
937777010606	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
937777010607	active site
937777010608	MarR family; Region: MarR_2; cl17246
937777010609	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
937777010610	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
937777010611	classical (c) SDRs; Region: SDR_c; cd05233
937777010612	NAD(P) binding site [chemical binding]; other site
937777010613	active site
937777010614	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
937777010615	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
937777010616	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
937777010617	motif II; other site
937777010618	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
937777010619	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
937777010620	putative substrate binding site [chemical binding]; other site
937777010621	putative ATP binding site [chemical binding]; other site
937777010622	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
937777010623	Glycoprotease family; Region: Peptidase_M22; pfam00814
937777010624	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
937777010625	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777010626	dimer interface [polypeptide binding]; other site
937777010627	conserved gate region; other site
937777010628	ABC-ATPase subunit interface; other site
937777010629	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777010630	dimer interface [polypeptide binding]; other site
937777010631	conserved gate region; other site
937777010632	putative PBP binding loops; other site
937777010633	ABC-ATPase subunit interface; other site
937777010634	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
937777010635	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
937777010636	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
937777010637	Divergent AAA domain; Region: AAA_4; pfam04326
937777010638	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
937777010639	tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142
937777010640	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
937777010641	Permutation of conserved domain; other site
937777010642	active site
937777010643	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cd01291
937777010644	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
937777010645	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
937777010646	G1 box; other site
937777010647	putative GEF interaction site [polypeptide binding]; other site
937777010648	GTP/Mg2+ binding site [chemical binding]; other site
937777010649	Switch I region; other site
937777010650	G2 box; other site
937777010651	G3 box; other site
937777010652	Switch II region; other site
937777010653	G4 box; other site
937777010654	G5 box; other site
937777010655	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
937777010656	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
937777010657	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
937777010658	Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096
937777010659	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
937777010660	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
937777010661	Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923
937777010662	Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096
937777010663	NodB motif; other site
937777010664	putative active site [active]
937777010665	putative catalytic site [active]
937777010666	putative Zn binding site [ion binding]; other site
937777010667	bacteriophage N4 adsorption protein B; Provisional; Region: PRK14716
937777010668	active site
937777010669	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
937777010670	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
937777010671	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
937777010672	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
937777010673	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
937777010674	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
937777010675	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
937777010676	ligand binding site; other site
937777010677	oligomer interface; other site
937777010678	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
937777010679	dimer interface [polypeptide binding]; other site
937777010680	N-terminal domain interface [polypeptide binding]; other site
937777010681	sulfate 1 binding site; other site
937777010682	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14468
937777010683	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
937777010684	FeS/SAM binding site; other site
937777010685	TPR repeat; Region: TPR_11; pfam13414
937777010686	TPR repeat; Region: TPR_11; pfam13414
937777010687	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
937777010688	binding surface
937777010689	TPR motif; other site
937777010690	TPR repeat; Region: TPR_11; pfam13414
937777010691	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
937777010692	binding surface
937777010693	TPR motif; other site
937777010694	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
937777010695	binding surface
937777010696	TPR motif; other site
937777010697	Sporulation related domain; Region: SPOR; pfam05036
937777010698	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
937777010699	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
937777010700	CoA binding domain; Region: CoA_binding; pfam02629
937777010701	Protein of unknown function (DUF970); Region: DUF970; pfam06153
937777010702	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
937777010703	Domain of unknown function (DUF814); Region: DUF814; pfam05670
937777010704	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
937777010705	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
937777010706	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
937777010707	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
937777010708	NAD binding site [chemical binding]; other site
937777010709	ligand binding site [chemical binding]; other site
937777010710	catalytic site [active]
937777010711	4-alpha-glucanotransferase; Provisional; Region: PRK14508
937777010712	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
937777010713	Ca2+ binding site [ion binding]; other site
937777010714	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
937777010715	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
937777010716	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
937777010717	active site
937777010718	metal binding site [ion binding]; metal-binding site
937777010719	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
937777010720	EDD domain protein, DegV family; Region: DegV; TIGR00762
937777010721	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
937777010722	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
937777010723	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
937777010724	active site
937777010725	aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159
937777010726	Asp_Lys_Asn_RS_N: N-terminal, anticodon recognition domain of class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop.  Class 2b aaRSs include the homodimeric aspartyl-; Region: Asp_Lys_Asn_RS_N; cd04100
937777010727	Dimer interface [polypeptide binding]; other site
937777010728	anticodon binding site; other site
937777010729	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
937777010730	motif 1; other site
937777010731	dimer interface [polypeptide binding]; other site
937777010732	active site
937777010733	motif 2; other site
937777010734	motif 3; other site
937777010735	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
937777010736	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
937777010737	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
937777010738	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
937777010739	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
937777010740	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
937777010741	Walker A/P-loop; other site
937777010742	ATP binding site [chemical binding]; other site
937777010743	Q-loop/lid; other site
937777010744	ABC transporter signature motif; other site
937777010745	Walker B; other site
937777010746	D-loop; other site
937777010747	H-loop/switch region; other site
937777010748	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
937777010749	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
937777010750	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
937777010751	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
937777010752	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
937777010753	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
937777010754	Peptidase M16C associated; Region: M16C_assoc; pfam08367
937777010755	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
937777010756	RNA binding surface [nucleotide binding]; other site
937777010757	Protein of unknown function (DUF1684); Region: DUF1684; pfam07920
937777010758	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
937777010759	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
937777010760	adenylate kinase; Region: adk; TIGR01351
937777010761	active site
937777010762	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
937777010763	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
937777010764	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
937777010765	DNA-binding site [nucleotide binding]; DNA binding site
937777010766	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
937777010767	pyridoxal 5'-phosphate binding site [chemical binding]; other site
937777010768	homodimer interface [polypeptide binding]; other site
937777010769	catalytic residue [active]
937777010770	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
937777010771	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
937777010772	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
937777010773	putative RNA binding site [nucleotide binding]; other site
937777010774	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
937777010775	S-adenosylmethionine binding site [chemical binding]; other site
937777010776	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
937777010777	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
937777010778	catalytic triad [active]
937777010779	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
937777010780	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
937777010781	Ligand Binding Site [chemical binding]; other site
937777010782	TilS substrate C-terminal domain; Region: TilS_C; smart00977
937777010783	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
937777010784	nucleoside/Zn binding site; other site
937777010785	dimer interface [polypeptide binding]; other site
937777010786	catalytic motif [active]
937777010787	Predicted phosphohydrolase [General function prediction only]; Region: COG1768
937777010788	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
937777010789	Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137
937777010790	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
937777010791	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
937777010792	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
937777010793	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
937777010794	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
937777010795	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
937777010796	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
937777010797	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
937777010798	active site
937777010799	catalytic site [active]
937777010800	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
937777010801	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
937777010802	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
937777010803	catalytic site [active]
937777010804	active site
937777010805	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
937777010806	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
937777010807	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
937777010808	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
937777010809	active site
937777010810	catalytic site [active]
937777010811	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
937777010812	active site
937777010813	DNA binding site [nucleotide binding]
937777010814	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
937777010815	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
937777010816	NAD binding site [chemical binding]; other site
937777010817	catalytic Zn binding site [ion binding]; other site
937777010818	structural Zn binding site [ion binding]; other site
937777010819	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
937777010820	putative hydrophobic ligand binding site [chemical binding]; other site
937777010821	Protein of unknown function (DUF419); Region: DUF419; pfam04237
937777010822	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
937777010823	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
937777010824	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
937777010825	dimer interface [polypeptide binding]; other site
937777010826	active site
937777010827	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
937777010828	catalytic residues [active]
937777010829	substrate binding site [chemical binding]; other site
937777010830	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
937777010831	FAD binding site [chemical binding]; other site
937777010832	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
937777010833	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
937777010834	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
937777010835	substrate binding pocket [chemical binding]; other site
937777010836	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
937777010837	B12 binding site [chemical binding]; other site
937777010838	cobalt ligand [ion binding]; other site
937777010839	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
937777010840	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
937777010841	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
937777010842	ATP-sulfurylase; Region: ATPS; cd00517
937777010843	active site
937777010844	HXXH motif; other site
937777010845	flexible loop; other site
937777010846	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
937777010847	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
937777010848	Active Sites [active]
937777010849	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
937777010850	ligand-binding site [chemical binding]; other site
937777010851	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
937777010852	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
937777010853	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
937777010854	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
937777010855	Rrf2 family protein; Region: rrf2_super; TIGR00738
937777010856	Transcriptional regulator; Region: Rrf2; pfam02082
937777010857	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
937777010858	active sites [active]
937777010859	tetramer interface [polypeptide binding]; other site
937777010860	imidazolonepropionase; Validated; Region: PRK09356
937777010861	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
937777010862	active site
937777010863	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
937777010864	active site
937777010865	metal binding site [ion binding]; metal-binding site
937777010866	urocanate hydratase; Provisional; Region: PRK05414
937777010867	major capsid protein; Provisional; Region: 23; PHA02541
937777010868	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
937777010869	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
937777010870	Na binding site [ion binding]; other site
937777010871	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
937777010872	Transcriptional regulator [Transcription]; Region: IclR; COG1414
937777010873	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
937777010874	Bacterial transcriptional regulator; Region: IclR; pfam01614
937777010875	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
937777010876	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
937777010877	metal binding site [ion binding]; metal-binding site
937777010878	active site
937777010879	I-site; other site
937777010880	Uncharacterized conserved protein [Function unknown]; Region: COG3342
937777010881	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
937777010882	Putative peptidoglycan binding domain; Region: PG_binding_2; pfam08823
937777010883	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
937777010884	Part of AAA domain; Region: AAA_19; pfam13245
937777010885	Family description; Region: UvrD_C_2; pfam13538
937777010886	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
937777010887	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
937777010888	Ligand Binding Site [chemical binding]; other site
937777010889	UGMP family protein; Validated; Region: PRK09604
937777010890	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
937777010891	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
937777010892	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
937777010893	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
937777010894	nucleotide binding region [chemical binding]; other site
937777010895	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
937777010896	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
937777010897	Walker A/P-loop; other site
937777010898	ATP binding site [chemical binding]; other site
937777010899	Q-loop/lid; other site
937777010900	ABC transporter signature motif; other site
937777010901	Walker B; other site
937777010902	D-loop; other site
937777010903	H-loop/switch region; other site
937777010904	TOBE domain; Region: TOBE; pfam03459
937777010905	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
937777010906	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
937777010907	substrate binding pocket [chemical binding]; other site
937777010908	membrane-bound complex binding site; other site
937777010909	hinge residues; other site
937777010910	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
937777010911	dimer interface [polypeptide binding]; other site
937777010912	conserved gate region; other site
937777010913	putative PBP binding loops; other site
937777010914	ABC-ATPase subunit interface; other site
937777010915	Uncharacterized conserved protein [Function unknown]; Region: COG3375
937777010916	N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317
937777010917	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
937777010918	active site
937777010919	octamer interface [polypeptide binding]; other site
937777010920	TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666
937777010921	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
937777010922	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
937777010923	membrane-bound complex binding site; other site
937777010924	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
937777010925	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
937777010926	Walker A/P-loop; other site
937777010927	ATP binding site [chemical binding]; other site
937777010928	Q-loop/lid; other site
937777010929	ABC transporter signature motif; other site
937777010930	Walker B; other site
937777010931	D-loop; other site
937777010932	H-loop/switch region; other site
937777010933	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
937777010934	Major Facilitator Superfamily; Region: MFS_1; pfam07690
937777010935	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
937777010936	Voltage gated chloride channel; Region: Voltage_CLC; pfam00654
937777010937	pore gating glutamate residue; other site
937777010938	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
937777010939	bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998
937777010940	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
937777010941	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
937777010942	ligand binding site [chemical binding]; other site
937777010943	flexible hinge region; other site
937777010944	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
937777010945	putative switch regulator; other site
937777010946	non-specific DNA interactions [nucleotide binding]; other site
937777010947	DNA binding site [nucleotide binding]
937777010948	sequence specific DNA binding site [nucleotide binding]; other site
937777010949	putative cAMP binding site [chemical binding]; other site
937777010950	2-phosphosulfolactate phosphatase; Provisional; Region: PRK14100
937777010951	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029
937777010952	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
937777010953	hypothetical protein; Provisional; Region: PRK07483
937777010954	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
937777010955	inhibitor-cofactor binding pocket; inhibition site
937777010956	pyridoxal 5'-phosphate binding site [chemical binding]; other site
937777010957	catalytic residue [active]
937777010958	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
937777010959	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
937777010960	Glutamate binding site [chemical binding]; other site
937777010961	homodimer interface [polypeptide binding]; other site
937777010962	NAD binding site [chemical binding]; other site
937777010963	catalytic residues [active]
937777010964	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
937777010965	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
937777010966	putative DNA binding site [nucleotide binding]; other site
937777010967	putative Zn2+ binding site [ion binding]; other site
937777010968	AsnC family; Region: AsnC_trans_reg; pfam01037
937777010969	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
937777010970	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
937777010971	FeS/SAM binding site; other site
937777010972	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
937777010973	4-aminobutyrate aminotransferase; Provisional; Region: PRK05769
937777010974	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
937777010975	inhibitor-cofactor binding pocket; inhibition site
937777010976	pyridoxal 5'-phosphate binding site [chemical binding]; other site
937777010977	catalytic residue [active]
937777010978	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
937777010979	generic binding surface I; other site
937777010980	generic binding surface II; other site
937777010981	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
937777010982	putative active site [active]
937777010983	putative catalytic site [active]
937777010984	putative Mg binding site IVb [ion binding]; other site
937777010985	putative phosphate binding site [ion binding]; other site
937777010986	putative DNA binding site [nucleotide binding]; other site
937777010987	putative Mg binding site IVa [ion binding]; other site
937777010988	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
937777010989	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
937777010990	Zn binding site [ion binding]; other site
937777010991	beta-phosphoglucomutase; Region: bPGM; TIGR01990
937777010992	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
937777010993	short chain dehydrogenase; Provisional; Region: PRK08219
937777010994	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
937777010995	NAD(P) binding site [chemical binding]; other site
937777010996	active site
937777010997	prephenate dehydrogenase; Validated; Region: PRK06545
937777010998	prephenate dehydrogenase; Validated; Region: PRK08507
937777010999	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
937777011000	hypothetical protein; Provisional; Region: PRK06446
937777011001	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681
937777011002	metal binding site [ion binding]; metal-binding site
937777011003	dimer interface [polypeptide binding]; other site
937777011004	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
937777011005	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
937777011006	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
937777011007	active site
937777011008	catalytic residues [active]
937777011009	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
937777011010	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
937777011011	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
937777011012	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
937777011013	16S rRNA methyltransferase B; Provisional; Region: PRK14902
937777011014	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
937777011015	S-adenosylmethionine binding site [chemical binding]; other site
937777011016	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
937777011017	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
937777011018	Walker A/P-loop; other site
937777011019	ATP binding site [chemical binding]; other site
937777011020	Q-loop/lid; other site
937777011021	ABC transporter signature motif; other site
937777011022	Walker B; other site
937777011023	D-loop; other site
937777011024	H-loop/switch region; other site
937777011025	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
937777011026	PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393
937777011027	active site
937777011028	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
937777011029	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
937777011030	ligand binding site [chemical binding]; other site
937777011031	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
937777011032	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
937777011033	nucleotide binding pocket [chemical binding]; other site
937777011034	K-X-D-G motif; other site
937777011035	catalytic site [active]
937777011036	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
937777011037	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
937777011038	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
937777011039	Dimer interface [polypeptide binding]; other site
937777011040	Asp23 family; Region: Asp23; cl00574
937777011041	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
937777011042	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14181
937777011043	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
937777011044	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
937777011045	homodimer interface [polypeptide binding]; other site
937777011046	NADP binding site [chemical binding]; other site
937777011047	substrate binding site [chemical binding]; other site
937777011048	Divergent PAP2 family; Region: DUF212; pfam02681
937777011049	NADH-quinone oxidoreductase chain 15; Region: NADH_Oxid_Nqo15; pfam11497
937777011050	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
937777011051	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
937777011052	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
937777011053	active site
937777011054	HIGH motif; other site
937777011055	KMSK motif region; other site
937777011056	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
937777011057	tRNA binding surface [nucleotide binding]; other site
937777011058	anticodon binding site; other site
937777011059	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
937777011060	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
937777011061	S-adenosylmethionine binding site [chemical binding]; other site
937777011062	isoleucyl-tRNA synthetase; Region: ileS; TIGR00392
937777011063	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
937777011064	active site
937777011065	HIGH motif; other site
937777011066	nucleotide binding site [chemical binding]; other site
937777011067	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
937777011068	active site
937777011069	KMSKS motif; other site
937777011070	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
937777011071	tRNA binding surface [nucleotide binding]; other site
937777011072	anticodon binding site; other site
937777011073	transcription termination factor Rho; Provisional; Region: rho; PRK09376
937777011074	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
937777011075	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
937777011076	RNA binding site [nucleotide binding]; other site
937777011077	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
937777011078	multimer interface [polypeptide binding]; other site
937777011079	Walker A motif; other site
937777011080	ATP binding site [chemical binding]; other site
937777011081	Walker B motif; other site
937777011082	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
937777011083	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
937777011084	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
937777011085	Peptidase family M23; Region: Peptidase_M23; pfam01551
937777011086	Response regulator receiver domain; Region: Response_reg; pfam00072
937777011087	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777011088	active site
937777011089	phosphorylation site [posttranslational modification]
937777011090	intermolecular recognition site; other site
937777011091	dimerization interface [polypeptide binding]; other site
937777011092	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
937777011093	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
937777011094	active site
937777011095	multimer interface [polypeptide binding]; other site
937777011096	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
937777011097	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181
937777011098	predicted active site [active]
937777011099	catalytic triad [active]
937777011100	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
937777011101	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
937777011102	oligoendopeptidase F; Region: pepF; TIGR00181
937777011103	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
937777011104	active site
937777011105	Zn binding site [ion binding]; other site
937777011106	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
937777011107	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
937777011108	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
937777011109	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
937777011110	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
937777011111	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
937777011112	active site
937777011113	triosephosphate isomerase; Provisional; Region: PRK14565
937777011114	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
937777011115	substrate binding site [chemical binding]; other site
937777011116	dimer interface [polypeptide binding]; other site
937777011117	catalytic triad [active]
937777011118	Phosphoglycerate kinase; Region: PGK; pfam00162
937777011119	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
937777011120	substrate binding site [chemical binding]; other site
937777011121	hinge regions; other site
937777011122	ADP binding site [chemical binding]; other site
937777011123	catalytic site [active]
937777011124	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
937777011125	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
937777011126	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
937777011127	aspartate kinase; Provisional; Region: PRK06291
937777011128	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
937777011129	nucleotide binding site [chemical binding]; other site
937777011130	substrate binding site [chemical binding]; other site
937777011131	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
937777011132	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
937777011133	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
937777011134	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
937777011135	putative dimer interface [polypeptide binding]; other site
937777011136	putative anticodon binding site; other site
937777011137	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
937777011138	homodimer interface [polypeptide binding]; other site
937777011139	motif 1; other site
937777011140	motif 2; other site
937777011141	active site
937777011142	motif 3; other site
937777011143	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
937777011144	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
937777011145	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
937777011146	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
937777011147	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
937777011148	dimer interface [polypeptide binding]; other site
937777011149	anticodon binding site; other site
937777011150	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
937777011151	homodimer interface [polypeptide binding]; other site
937777011152	motif 1; other site
937777011153	active site
937777011154	motif 2; other site
937777011155	GAD domain; Region: GAD; pfam02938
937777011156	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
937777011157	active site
937777011158	motif 3; other site
937777011159	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
937777011160	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
937777011161	dimer interface [polypeptide binding]; other site
937777011162	motif 1; other site
937777011163	active site
937777011164	motif 2; other site
937777011165	motif 3; other site
937777011166	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
937777011167	anticodon binding site; other site
937777011168	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
937777011169	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
937777011170	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
937777011171	active site
937777011172	DNA binding site [nucleotide binding]
937777011173	Int/Topo IB signature motif; other site
937777011174	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
937777011175	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
937777011176	active site
937777011177	DNA binding site [nucleotide binding]
937777011178	Int/Topo IB signature motif; other site
937777011179	Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936
937777011180	Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078
937777011181	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
937777011182	Walker A/P-loop; other site
937777011183	ATP binding site [chemical binding]; other site
937777011184	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
937777011185	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
937777011186	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
937777011187	ABC transporter signature motif; other site
937777011188	Walker B; other site
937777011189	D-loop; other site
937777011190	H-loop/switch region; other site
937777011191	Sporulation and spore germination; Region: Germane; pfam10646
937777011192	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
937777011193	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713
937777011194	active site
937777011195	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
937777011196	SmpB-tmRNA interface; other site
937777011197	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
937777011198	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
937777011199	putative active site [active]
937777011200	catalytic triad [active]
937777011201	putative dimer interface [polypeptide binding]; other site
937777011202	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
937777011203	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
937777011204	active site
937777011205	metal binding site [ion binding]; metal-binding site
937777011206	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
937777011207	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
937777011208	metal binding site [ion binding]; metal-binding site
937777011209	active site
937777011210	I-site; other site
937777011211	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
937777011212	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
937777011213	homodimer interface [polypeptide binding]; other site
937777011214	pyridoxal 5'-phosphate binding site [chemical binding]; other site
937777011215	catalytic residue [active]
937777011216	Acetokinase family; Region: Acetate_kinase; cl17229
937777011217	propionate/acetate kinase; Provisional; Region: PRK12379
937777011218	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
937777011219	dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232
937777011220	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
937777011221	Zn2+ binding site [ion binding]; other site
937777011222	Mg2+ binding site [ion binding]; other site
937777011223	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
937777011224	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
937777011225	substrate binding site [chemical binding]; other site
937777011226	active site
937777011227	catalytic residues [active]
937777011228	heterodimer interface [polypeptide binding]; other site
937777011229	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
937777011230	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
937777011231	pyridoxal 5'-phosphate binding site [chemical binding]; other site
937777011232	catalytic residue [active]
937777011233	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
937777011234	active site
937777011235	HIGH motif; other site
937777011236	nucleotide binding site [chemical binding]; other site
937777011237	active site
937777011238	KMSKS motif; other site
937777011239	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
937777011240	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
937777011241	active site
937777011242	catalytic site [active]
937777011243	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
937777011244	Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077
937777011245	calcium binding site 2 [ion binding]; other site
937777011246	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
937777011247	active site
937777011248	catalytic triad [active]
937777011249	calcium binding site 1 [ion binding]; other site
937777011250	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
937777011251	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
937777011252	active site
937777011253	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
937777011254	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
937777011255	GIY-YIG motif/motif A; other site
937777011256	active site
937777011257	catalytic site [active]
937777011258	putative DNA binding site [nucleotide binding]; other site
937777011259	metal binding site [ion binding]; metal-binding site
937777011260	UvrB/uvrC motif; Region: UVR; pfam02151
937777011261	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
937777011262	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
937777011263	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
937777011264	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
937777011265	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
937777011266	putative dimer interface [polypeptide binding]; other site
937777011267	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
937777011268	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
937777011269	4Fe-4S binding domain; Region: Fer4; cl02805
937777011270	Cysteine-rich domain; Region: CCG; pfam02754
937777011271	Cysteine-rich domain; Region: CCG; pfam02754
937777011272	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
937777011273	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
937777011274	purine monophosphate binding site [chemical binding]; other site
937777011275	dimer interface [polypeptide binding]; other site
937777011276	putative catalytic residues [active]
937777011277	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
937777011278	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
937777011279	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
937777011280	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
937777011281	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
937777011282	homodimer interface [polypeptide binding]; other site
937777011283	NADP binding site [chemical binding]; other site
937777011284	substrate binding site [chemical binding]; other site
937777011285	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
937777011286	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
937777011287	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
937777011288	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
937777011289	homodimer interface [polypeptide binding]; other site
937777011290	substrate-cofactor binding pocket; other site
937777011291	pyridoxal 5'-phosphate binding site [chemical binding]; other site
937777011292	catalytic residue [active]
937777011293	acylphosphatase; Provisional; Region: PRK14433
937777011294	Family of unknown function (DUF490); Region: DUF490; pfam04357
937777011295	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
937777011296	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
937777011297	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
937777011298	ABC transporter; Region: ABC_tran_2; pfam12848
937777011299	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
937777011300	Walker A/P-loop; other site
937777011301	ATP binding site [chemical binding]; other site
937777011302	Q-loop/lid; other site
937777011303	ABC transporter signature motif; other site
937777011304	Walker B; other site
937777011305	D-loop; other site
937777011306	H-loop/switch region; other site
937777011307	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
937777011308	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
937777011309	CoA-ligase; Region: Ligase_CoA; pfam00549
937777011310	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
937777011311	CoA binding domain; Region: CoA_binding; smart00881
937777011312	CoA-ligase; Region: Ligase_CoA; pfam00549
937777011313	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
937777011314	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
937777011315	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
937777011316	trehalose synthase; Region: treS_nterm; TIGR02456
937777011317	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
937777011318	active site
937777011319	catalytic site [active]
937777011320	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
937777011321	monoglyceride lipase; Provisional; Region: PHA02857
937777011322	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
937777011323	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
937777011324	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
937777011325	active site
937777011326	substrate-binding site [chemical binding]; other site
937777011327	metal-binding site [ion binding]
937777011328	ATP binding site [chemical binding]; other site
937777011329	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
937777011330	Protein of unknown function (DUF1806); Region: DUF1806; pfam08830
937777011331	MoxR-like ATPases [General function prediction only]; Region: COG0714
937777011332	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
937777011333	Walker A motif; other site
937777011334	ATP binding site [chemical binding]; other site
937777011335	Walker B motif; other site
937777011336	arginine finger; other site
937777011337	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
937777011338	Protein of unknown function DUF58; Region: DUF58; pfam01882
937777011339	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
937777011340	metal ion-dependent adhesion site (MIDAS); other site
937777011341	von Willebrand factor type A domain; Region: VWA_2; pfam13519
937777011342	metal ion-dependent adhesion site (MIDAS); other site
937777011343	von Willebrand factor type A domain; Region: VWA_2; pfam13519
937777011344	metal ion-dependent adhesion site (MIDAS); other site
937777011345	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
937777011346	CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918
937777011347	ligand binding site [chemical binding]; other site
937777011348	flexible hinge region; other site
937777011349	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
937777011350	non-specific DNA interactions [nucleotide binding]; other site
937777011351	DNA binding site [nucleotide binding]
937777011352	sequence specific DNA binding site [nucleotide binding]; other site
937777011353	putative cAMP binding site [chemical binding]; other site
937777011354	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
937777011355	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
937777011356	substrate binding pocket [chemical binding]; other site
937777011357	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
937777011358	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
937777011359	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
937777011360	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
937777011361	putative L-serine binding site [chemical binding]; other site
937777011362	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
937777011363	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
937777011364	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
937777011365	active site
937777011366	catalytic residues [active]
937777011367	Predicted transcriptional regulators [Transcription]; Region: COG1695
937777011368	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
937777011369	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
937777011370	GAF domain; Region: GAF_2; pfam13185
937777011371	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
937777011372	dimer interface [polypeptide binding]; other site
937777011373	phosphorylation site [posttranslational modification]
937777011374	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
937777011375	ATP binding site [chemical binding]; other site
937777011376	Mg2+ binding site [ion binding]; other site
937777011377	G-X-G motif; other site
937777011378	Response regulator receiver domain; Region: Response_reg; pfam00072
937777011379	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
937777011380	active site
937777011381	phosphorylation site [posttranslational modification]
937777011382	intermolecular recognition site; other site
937777011383	dimerization interface [polypeptide binding]; other site
937777011384	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
937777011385	Winged helix-turn helix; Region: HTH_33; pfam13592
937777011386	Predicted transcriptional regulators [Transcription]; Region: COG1733
937777011387	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
937777011388	Predicted transcriptional regulators [Transcription]; Region: COG1733
937777011389	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
937777011390	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
937777011391	NADH(P)-binding; Region: NAD_binding_10; pfam13460
937777011392	NAD binding site [chemical binding]; other site
937777011393	substrate binding site [chemical binding]; other site
937777011394	putative active site [active]
937777011395	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
937777011396	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
937777011397	putative NAD(P) binding site [chemical binding]; other site
937777011398	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
937777011399	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
937777011400	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
937777011401	META domain; Region: META; pfam03724
937777011402	META domain; Region: META; pfam03724
937777011403	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
937777011404	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
937777011405	HIGH motif; other site
937777011406	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
937777011407	active site
937777011408	KMSKS motif; other site
937777011409	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
937777011410	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
937777011411	DNA-binding site [nucleotide binding]; DNA binding site
937777011412	UTRA domain; Region: UTRA; pfam07702
937777011413	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
937777011414	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
937777011415	iron-sulfur cluster [ion binding]; other site
937777011416	[2Fe-2S] cluster binding site [ion binding]; other site
937777011417	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
937777011418	FeS assembly protein SufD; Region: sufD; TIGR01981
937777011419	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
937777011420	FeS assembly protein SufB; Region: sufB; TIGR01980
937777011421	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
937777011422	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
937777011423	Walker A/P-loop; other site
937777011424	ATP binding site [chemical binding]; other site
937777011425	Q-loop/lid; other site
937777011426	ABC transporter signature motif; other site
937777011427	Walker B; other site
937777011428	D-loop; other site
937777011429	H-loop/switch region; other site
937777011430	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
937777011431	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
937777011432	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
937777011433	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
937777011434	nucleotide binding site [chemical binding]; other site
937777011435	chaperone protein DnaJ; Provisional; Region: PRK14292
937777011436	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
937777011437	HSP70 interaction site [polypeptide binding]; other site
937777011438	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
937777011439	Zn binding sites [ion binding]; other site
937777011440	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
937777011441	dimer interface [polypeptide binding]; other site
937777011442	Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462
937777011443	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
937777011444	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
937777011445	active site
937777011446	Predicted membrane protein (DUF2243); Region: DUF2243; cl01783
937777011447	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
937777011448	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
937777011449	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
937777011450	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
937777011451	active site
937777011452	Transcriptional regulators [Transcription]; Region: PurR; COG1609
937777011453	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
937777011454	DNA binding site [nucleotide binding]
937777011455	domain linker motif; other site
937777011456	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
937777011457	dimerization interface (closed form) [polypeptide binding]; other site
937777011458	ligand binding site [chemical binding]; other site
937777011459	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
937777011460	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
937777011461	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
937777011462	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
937777011463	acetyl-CoA acetyltransferase; Provisional; Region: PRK07661
937777011464	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
937777011465	dimer interface [polypeptide binding]; other site
937777011466	active site
937777011467	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
937777011468	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
937777011469	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
937777011470	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
937777011471	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
937777011472	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
937777011473	substrate binding site [chemical binding]; other site
937777011474	oxyanion hole (OAH) forming residues; other site
937777011475	trimer interface [polypeptide binding]; other site
937777011476	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
937777011477	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
937777011478	Active site serine [active]
937777011479	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
937777011480	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
937777011481	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
937777011482	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
937777011483	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
937777011484	inhibitor-cofactor binding pocket; inhibition site
937777011485	pyridoxal 5'-phosphate binding site [chemical binding]; other site
937777011486	catalytic residue [active]
937777011487	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118
937777011488	dimer interface [polypeptide binding]; other site
937777011489	Citrate synthase; Region: Citrate_synt; pfam00285
937777011490	active site
937777011491	coenzyme A binding site [chemical binding]; other site
937777011492	citrylCoA binding site [chemical binding]; other site
937777011493	oxalacetate/citrate binding site [chemical binding]; other site
937777011494	catalytic triad [active]
937777011495	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
937777011496	MutS domain III; Region: MutS_III; pfam05192
937777011497	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
937777011498	Walker A/P-loop; other site
937777011499	ATP binding site [chemical binding]; other site
937777011500	Q-loop/lid; other site
937777011501	ABC transporter signature motif; other site
937777011502	Walker B; other site
937777011503	D-loop; other site
937777011504	H-loop/switch region; other site
937777011505	Smr domain; Region: Smr; pfam01713
937777011506	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
937777011507	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
937777011508	putative active site [active]
937777011509	putative metal binding site [ion binding]; other site
937777011510	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666
937777011511	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
937777011512	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
937777011513	S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711
937777011514	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
937777011515	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
937777011516	tartrate dehydrogenase; Region: TTC; TIGR02089
937777011517	type IV pilus assembly protein PilM; Region: pilM; TIGR01175
937777011518	Cell division protein FtsA; Region: FtsA; pfam14450
937777011519	Pilus assembly protein, PilO; Region: PilO; cl01234
937777011520	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
937777011521	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
937777011522	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
937777011523	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
937777011524	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
937777011525	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
937777011526	Tetramer interface [polypeptide binding]; other site
937777011527	active site
937777011528	FMN-binding site [chemical binding]; other site
937777011529	shikimate kinase; Provisional; Region: PRK13948
937777011530	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
937777011531	ADP binding site [chemical binding]; other site
937777011532	magnesium binding site [ion binding]; other site
937777011533	putative shikimate binding site; other site
937777011534	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
937777011535	active site
937777011536	dimer interface [polypeptide binding]; other site
937777011537	metal binding site [ion binding]; metal-binding site
937777011538	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
937777011539	Dehydroquinase class II; Region: DHquinase_II; pfam01220
937777011540	active site
937777011541	trimer interface [polypeptide binding]; other site
937777011542	dimer interface [polypeptide binding]; other site
937777011543	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
937777011544	23S rRNA interface [nucleotide binding]; other site
937777011545	L3 interface [polypeptide binding]; other site
937777011546	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
937777011547	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
937777011548	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
937777011549	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
937777011550	Zn2+ binding site [ion binding]; other site
937777011551	Mg2+ binding site [ion binding]; other site
937777011552	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
937777011553	synthetase active site [active]
937777011554	NTP binding site [chemical binding]; other site
937777011555	metal binding site [ion binding]; metal-binding site
937777011556	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
937777011557	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876