-- dump date 20140619_060541 -- class Genbank::misc_feature -- table misc_feature_note -- id note 693977000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 693977000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 693977000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693977000004 Walker A motif; other site 693977000005 ATP binding site [chemical binding]; other site 693977000006 Walker B motif; other site 693977000007 arginine finger; other site 693977000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 693977000009 DnaA box-binding interface [nucleotide binding]; other site 693977000010 DNA polymerase III subunit beta; Provisional; Region: PRK14945 693977000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 693977000012 putative DNA binding surface [nucleotide binding]; other site 693977000013 dimer interface [polypeptide binding]; other site 693977000014 beta-clamp/clamp loader binding surface; other site 693977000015 beta-clamp/translesion DNA polymerase binding surface; other site 693977000016 enolase; Provisional; Region: eno; PRK00077 693977000017 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 693977000018 dimer interface [polypeptide binding]; other site 693977000019 metal binding site [ion binding]; metal-binding site 693977000020 substrate binding pocket [chemical binding]; other site 693977000021 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 693977000022 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 693977000023 domain interfaces; other site 693977000024 active site 693977000025 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 693977000026 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 693977000027 active site 693977000028 HIGH motif; other site 693977000029 dimer interface [polypeptide binding]; other site 693977000030 KMSKS motif; other site 693977000031 MOSC domain; Region: MOSC; pfam03473 693977000032 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 693977000033 nudix motif; other site 693977000034 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693977000035 S-adenosylmethionine binding site [chemical binding]; other site 693977000036 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 693977000037 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 693977000038 active site 693977000039 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 693977000040 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 693977000041 metal binding site [ion binding]; metal-binding site 693977000042 dimer interface [polypeptide binding]; other site 693977000043 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 693977000044 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 693977000045 active site 693977000046 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 693977000047 putative catalytic site [active] 693977000048 putative metal binding site [ion binding]; other site 693977000049 putative phosphate binding site [ion binding]; other site 693977000050 short chain dehydrogenase; Provisional; Region: PRK07576 693977000051 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 693977000052 NAD(P) binding site [chemical binding]; other site 693977000053 substrate binding site [chemical binding]; other site 693977000054 homotetramer interface [polypeptide binding]; other site 693977000055 active site 693977000056 homodimer interface [polypeptide binding]; other site 693977000057 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 693977000058 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693977000059 substrate binding site [chemical binding]; other site 693977000060 oxyanion hole (OAH) forming residues; other site 693977000061 trimer interface [polypeptide binding]; other site 693977000062 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 693977000063 pyridoxamine kinase; Validated; Region: PRK05756 693977000064 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 693977000065 dimer interface [polypeptide binding]; other site 693977000066 pyridoxal binding site [chemical binding]; other site 693977000067 ATP binding site [chemical binding]; other site 693977000068 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 693977000069 Peptidase family M23; Region: Peptidase_M23; pfam01551 693977000070 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 693977000071 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693977000072 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 693977000073 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 693977000074 active site residue [active] 693977000075 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 693977000076 active site residue [active] 693977000077 Fe-S metabolism associated domain; Region: SufE; cl00951 693977000078 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 693977000079 active site 693977000080 dimerization interface [polypeptide binding]; other site 693977000081 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 693977000082 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 693977000083 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 693977000084 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 693977000085 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693977000086 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 693977000087 Predicted membrane protein [Function unknown]; Region: COG4270 693977000088 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 693977000089 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 693977000090 active site 693977000091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693977000092 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693977000093 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 693977000094 Peptidase S8 family domain, uncharacterized subfamily 5; Region: Peptidases_S8_5; cd07489 693977000095 active site 693977000096 catalytic triad [active] 693977000097 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 693977000098 PA/protease or protease-like domain interface [polypeptide binding]; other site 693977000099 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 693977000100 catalytic residues [active] 693977000101 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 693977000102 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 693977000103 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 693977000104 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 693977000105 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693977000106 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 693977000107 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693977000108 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 693977000109 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693977000110 FeS/SAM binding site; other site 693977000111 HemN C-terminal domain; Region: HemN_C; pfam06969 693977000112 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 693977000113 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 693977000114 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693977000115 Zn2+ binding site [ion binding]; other site 693977000116 Mg2+ binding site [ion binding]; other site 693977000117 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693977000118 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 693977000119 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693977000120 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 693977000121 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 693977000122 16S/18S rRNA binding site [nucleotide binding]; other site 693977000123 S13e-L30e interaction site [polypeptide binding]; other site 693977000124 25S rRNA binding site [nucleotide binding]; other site 693977000125 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 693977000126 trimer interface [polypeptide binding]; other site 693977000127 dimer interface [polypeptide binding]; other site 693977000128 putative active site [active] 693977000129 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 693977000130 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 693977000131 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 693977000132 substrate binding site; other site 693977000133 metal-binding site 693977000134 Oligomer interface; other site 693977000135 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 693977000136 putative trimer interface [polypeptide binding]; other site 693977000137 putative CoA binding site [chemical binding]; other site 693977000138 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 693977000139 metal binding site 2 [ion binding]; metal-binding site 693977000140 putative DNA binding helix; other site 693977000141 metal binding site 1 [ion binding]; metal-binding site 693977000142 dimer interface [polypeptide binding]; other site 693977000143 structural Zn2+ binding site [ion binding]; other site 693977000144 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 693977000145 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 693977000146 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 693977000147 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 693977000148 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 693977000149 NAD(P) binding pocket [chemical binding]; other site 693977000150 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 693977000151 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 693977000152 purine monophosphate binding site [chemical binding]; other site 693977000153 dimer interface [polypeptide binding]; other site 693977000154 putative catalytic residues [active] 693977000155 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 693977000156 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 693977000157 Haemolytic domain; Region: Haemolytic; cl00506 693977000158 RNase P protein component [Translation, ribosomal structure and biogenesis]; Region: RnpA; COG0594 693977000159 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 693977000160 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 693977000161 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 693977000162 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693977000163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693977000164 active site 693977000165 phosphorylation site [posttranslational modification] 693977000166 intermolecular recognition site; other site 693977000167 dimerization interface [polypeptide binding]; other site 693977000168 Uncharacterized conserved protein [Function unknown]; Region: COG1801 693977000169 Protein of unknown function (DUF817); Region: DUF817; pfam05675 693977000170 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 693977000171 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 693977000172 FMN binding site [chemical binding]; other site 693977000173 active site 693977000174 catalytic residues [active] 693977000175 substrate binding site [chemical binding]; other site 693977000176 e3 binding domain; Region: E3_binding; pfam02817 693977000177 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 693977000178 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 693977000179 GDP-binding site [chemical binding]; other site 693977000180 ACT binding site; other site 693977000181 IMP binding site; other site 693977000182 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 693977000183 homodecamer interface [polypeptide binding]; other site 693977000184 GTP cyclohydrolase I; Provisional; Region: PLN03044 693977000185 active site 693977000186 putative catalytic site residues [active] 693977000187 zinc binding site [ion binding]; other site 693977000188 GTP-CH-I/GFRP interaction surface; other site 693977000189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719 693977000190 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 693977000191 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 693977000192 metal ion-dependent adhesion site (MIDAS); other site 693977000193 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 693977000194 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 693977000195 Ligand Binding Site [chemical binding]; other site 693977000196 TIGR00269 family protein; Region: TIGR00269 693977000197 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 693977000198 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 693977000199 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 693977000200 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 693977000201 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 693977000202 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 693977000203 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 693977000204 NAD(P) binding site [chemical binding]; other site 693977000205 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 693977000206 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 693977000207 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 693977000208 NAD(P) binding site [chemical binding]; other site 693977000209 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 693977000210 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 693977000211 substrate binding pocket [chemical binding]; other site 693977000212 chain length determination region; other site 693977000213 substrate-Mg2+ binding site; other site 693977000214 catalytic residues [active] 693977000215 aspartate-rich region 1; other site 693977000216 active site lid residues [active] 693977000217 aspartate-rich region 2; other site 693977000218 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 693977000219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693977000220 S-adenosylmethionine binding site [chemical binding]; other site 693977000221 Protein of unknown function (DUF461); Region: DUF461; pfam04314 693977000222 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 693977000223 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 693977000224 Cu(I) binding site [ion binding]; other site 693977000225 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 693977000226 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693977000227 EDD domain protein, DegV family; Region: DegV; TIGR00762 693977000228 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 693977000229 Uncharacterized conserved protein [Function unknown]; Region: COG3339 693977000230 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 693977000231 nudix motif; other site 693977000232 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 693977000233 PHP domain; Region: PHP; pfam02811 693977000234 active site 693977000235 PHP Thumb interface [polypeptide binding]; other site 693977000236 metal binding site [ion binding]; metal-binding site 693977000237 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 693977000238 DNA polymerase III subunit alpha; Reviewed; Region: PRK07373 693977000239 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 693977000240 generic binding surface II; other site 693977000241 generic binding surface I; other site 693977000242 Protein of unknown function DUF72; Region: DUF72; pfam01904 693977000243 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 693977000244 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 693977000245 S-layer homology domain; Region: SLH; pfam00395 693977000246 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 693977000247 DHH family; Region: DHH; pfam01368 693977000248 DHHA2 domain; Region: DHHA2; pfam02833 693977000249 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 693977000250 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693977000251 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693977000252 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693977000253 sequence-specific DNA binding site [nucleotide binding]; other site 693977000254 salt bridge; other site 693977000255 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 693977000256 malate dehydrogenase; Provisional; Region: PRK05442 693977000257 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 693977000258 NAD(P) binding site [chemical binding]; other site 693977000259 dimer interface [polypeptide binding]; other site 693977000260 malate binding site [chemical binding]; other site 693977000261 primosomal protein N' Region: priA; TIGR00595 693977000262 Protein of unknown function (DUF808); Region: DUF808; cl01002 693977000263 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 693977000264 Predicted transporter component [General function prediction only]; Region: COG2391 693977000265 Sulphur transport; Region: Sulf_transp; pfam04143 693977000266 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 693977000267 Methyltransferase domain; Region: Methyltransf_18; pfam12847 693977000268 S-adenosylmethionine binding site [chemical binding]; other site 693977000269 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 693977000270 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 693977000271 active site residue [active] 693977000272 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 693977000273 active site residue [active] 693977000274 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 693977000275 putative homodimer interface [polypeptide binding]; other site 693977000276 putative homotetramer interface [polypeptide binding]; other site 693977000277 putative allosteric switch controlling residues; other site 693977000278 putative metal binding site [ion binding]; other site 693977000279 putative homodimer-homodimer interface [polypeptide binding]; other site 693977000280 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693977000281 S-adenosylmethionine binding site [chemical binding]; other site 693977000282 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 693977000283 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 693977000284 active site 693977000285 metal binding site [ion binding]; metal-binding site 693977000286 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 693977000287 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 693977000288 ligand binding site; other site 693977000289 oligomer interface; other site 693977000290 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 693977000291 dimer interface [polypeptide binding]; other site 693977000292 N-terminal domain interface [polypeptide binding]; other site 693977000293 sulfate 1 binding site; other site 693977000294 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 693977000295 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 693977000296 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 693977000297 intersubunit interface [polypeptide binding]; other site 693977000298 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 693977000299 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 693977000300 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 693977000301 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 693977000302 ABC-ATPase subunit interface; other site 693977000303 dimer interface [polypeptide binding]; other site 693977000304 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 693977000305 metal-dependent hydrolase; Provisional; Region: PRK00685 693977000306 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 693977000307 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 693977000308 Dynamin family; Region: Dynamin_N; pfam00350 693977000309 G1 box; other site 693977000310 GTP/Mg2+ binding site [chemical binding]; other site 693977000311 G2 box; other site 693977000312 Switch I region; other site 693977000313 G3 box; other site 693977000314 Switch II region; other site 693977000315 G4 box; other site 693977000316 G5 box; other site 693977000317 Transcriptional regulator [Transcription]; Region: IclR; COG1414 693977000318 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 693977000319 Bacterial transcriptional regulator; Region: IclR; pfam01614 693977000320 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 693977000321 active site clefts [active] 693977000322 zinc binding site [ion binding]; other site 693977000323 dimer interface [polypeptide binding]; other site 693977000324 DNA packaging tegument protein UL25; Provisional; Region: PHA03248 693977000325 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 693977000326 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693977000327 dimer interface [polypeptide binding]; other site 693977000328 phosphorylation site [posttranslational modification] 693977000329 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693977000330 ATP binding site [chemical binding]; other site 693977000331 Mg2+ binding site [ion binding]; other site 693977000332 G-X-G motif; other site 693977000333 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693977000334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693977000335 active site 693977000336 phosphorylation site [posttranslational modification] 693977000337 intermolecular recognition site; other site 693977000338 dimerization interface [polypeptide binding]; other site 693977000339 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693977000340 DNA binding site [nucleotide binding] 693977000341 Oligomerisation domain; Region: Oligomerisation; cl00519 693977000342 Transcriptional regulator [Transcription]; Region: LytR; COG1316 693977000343 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 693977000344 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 693977000345 Uncharacterized conserved protein [Function unknown]; Region: COG1624 693977000346 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 693977000347 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04135 693977000348 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 693977000349 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 693977000350 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 693977000351 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 693977000352 DDE superfamily endonuclease; Region: DDE_3; pfam13358 693977000353 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 693977000354 UPF0126 domain; Region: UPF0126; pfam03458 693977000355 Predicted membrane protein [Function unknown]; Region: COG2860 693977000356 UPF0126 domain; Region: UPF0126; pfam03458 693977000357 hypothetical protein; Validated; Region: PRK00110 693977000358 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 693977000359 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693977000360 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 693977000361 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 693977000362 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693977000363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693977000364 active site 693977000365 phosphorylation site [posttranslational modification] 693977000366 intermolecular recognition site; other site 693977000367 dimerization interface [polypeptide binding]; other site 693977000368 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693977000369 DNA binding site [nucleotide binding] 693977000370 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 693977000371 putative active site pocket [active] 693977000372 cleavage site 693977000373 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 693977000374 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 693977000375 active site 693977000376 catalytic residues [active] 693977000377 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 693977000378 hypothetical protein; Reviewed; Region: PRK09588 693977000379 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 693977000380 CoenzymeA binding site [chemical binding]; other site 693977000381 subunit interaction site [polypeptide binding]; other site 693977000382 PHB binding site; other site 693977000383 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 693977000384 active site 693977000385 Predicted membrane protein [Function unknown]; Region: COG2261 693977000386 homoserine kinase; Provisional; Region: PRK01212 693977000387 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 693977000388 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693977000389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693977000390 active site 693977000391 phosphorylation site [posttranslational modification] 693977000392 intermolecular recognition site; other site 693977000393 dimerization interface [polypeptide binding]; other site 693977000394 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693977000395 DNA binding residues [nucleotide binding] 693977000396 dimerization interface [polypeptide binding]; other site 693977000397 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 693977000398 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 693977000399 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 693977000400 iron-sulfur cluster [ion binding]; other site 693977000401 [2Fe-2S] cluster binding site [ion binding]; other site 693977000402 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 693977000403 intrachain domain interface; other site 693977000404 heme bL binding site [chemical binding]; other site 693977000405 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 693977000406 heme bH binding site [chemical binding]; other site 693977000407 Qo binding site; other site 693977000408 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 693977000409 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 693977000410 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693977000411 DNA-binding site [nucleotide binding]; DNA binding site 693977000412 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693977000413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693977000414 homodimer interface [polypeptide binding]; other site 693977000415 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 693977000416 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 693977000417 active site 693977000418 multimer interface [polypeptide binding]; other site 693977000419 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 693977000420 predicted active site [active] 693977000421 catalytic triad [active] 693977000422 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 693977000423 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 693977000424 HflX GTPase family; Region: HflX; cd01878 693977000425 G1 box; other site 693977000426 GTP/Mg2+ binding site [chemical binding]; other site 693977000427 Switch I region; other site 693977000428 G2 box; other site 693977000429 G3 box; other site 693977000430 Switch II region; other site 693977000431 G4 box; other site 693977000432 G5 box; other site 693977000433 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 693977000434 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 693977000435 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693977000436 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693977000437 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 693977000438 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 693977000439 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 693977000440 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 693977000441 dimer interface [polypeptide binding]; other site 693977000442 putative functional site; other site 693977000443 putative MPT binding site; other site 693977000444 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 693977000445 Chorismate mutase type II; Region: CM_2; cl00693 693977000446 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 693977000447 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 693977000448 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 693977000449 Predicted transcriptional regulator [Transcription]; Region: COG2345 693977000450 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693977000451 putative Zn2+ binding site [ion binding]; other site 693977000452 putative DNA binding site [nucleotide binding]; other site 693977000453 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 693977000454 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 693977000455 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 693977000456 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 693977000457 Peroxiredoxin (PRX) family; composed of the different classes of PRXs including many proteins originally known as bacterioferritin comigratory proteins (BCP), based on their electrophoretic mobility before their function was identified. PRXs are...; Region: PRX_family; cd02971 693977000458 catalytic triad [active] 693977000459 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 693977000460 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 693977000461 HRDC domain; Region: HRDC; pfam00570 693977000462 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693977000463 active site 693977000464 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 693977000465 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 693977000466 active site 693977000467 metal binding site [ion binding]; metal-binding site 693977000468 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693977000469 Coenzyme A binding pocket [chemical binding]; other site 693977000470 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 693977000471 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 693977000472 FMN binding site [chemical binding]; other site 693977000473 active site 693977000474 catalytic residues [active] 693977000475 substrate binding site [chemical binding]; other site 693977000476 Predicted transcriptional regulator [Transcription]; Region: COG2378 693977000477 HTH domain; Region: HTH_11; pfam08279 693977000478 WYL domain; Region: WYL; pfam13280 693977000479 Uncharacterized conserved protein [Function unknown]; Region: COG1416 693977000480 DinB family; Region: DinB; cl17821 693977000481 DinB superfamily; Region: DinB_2; pfam12867 693977000482 DinB family; Region: DinB; cl17821 693977000483 DinB superfamily; Region: DinB_2; pfam12867 693977000484 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 693977000485 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 693977000486 domain interfaces; other site 693977000487 active site 693977000488 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 693977000489 active site 693977000490 homotetramer interface [polypeptide binding]; other site 693977000491 homodimer interface [polypeptide binding]; other site 693977000492 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 693977000493 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 693977000494 active site 693977000495 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 693977000496 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 693977000497 ATP binding site [chemical binding]; other site 693977000498 active site 693977000499 substrate binding site [chemical binding]; other site 693977000500 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 693977000501 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 693977000502 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 693977000503 putative active site [active] 693977000504 catalytic triad [active] 693977000505 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 693977000506 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 693977000507 dimerization interface [polypeptide binding]; other site 693977000508 ATP binding site [chemical binding]; other site 693977000509 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 693977000510 dimerization interface [polypeptide binding]; other site 693977000511 ATP binding site [chemical binding]; other site 693977000512 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 693977000513 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 693977000514 active site 693977000515 tetramer interface [polypeptide binding]; other site 693977000516 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693977000517 active site 693977000518 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 693977000519 trimer interface [polypeptide binding]; other site 693977000520 active site 693977000521 PemK-like protein; Region: PemK; pfam02452 693977000522 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 693977000523 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 693977000524 catalytic core [active] 693977000525 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 693977000526 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 693977000527 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 693977000528 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 693977000529 D-pathway; other site 693977000530 Low-spin heme binding site [chemical binding]; other site 693977000531 Putative water exit pathway; other site 693977000532 Binuclear center (active site) [active] 693977000533 K-pathway; other site 693977000534 Putative proton exit pathway; other site 693977000535 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 693977000536 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 693977000537 C-terminal peptidase (prc); Region: prc; TIGR00225 693977000538 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 693977000539 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 693977000540 Active site serine [active] 693977000541 multidrug resistance protein MdtH; Provisional; Region: PRK11646 693977000542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693977000543 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 693977000544 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 693977000545 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 693977000546 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 693977000547 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 693977000548 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 693977000549 PAS domain; Region: PAS_9; pfam13426 693977000550 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693977000551 putative active site [active] 693977000552 heme pocket [chemical binding]; other site 693977000553 PAS domain; Region: PAS_9; pfam13426 693977000554 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693977000555 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693977000556 metal binding site [ion binding]; metal-binding site 693977000557 active site 693977000558 I-site; other site 693977000559 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693977000560 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 693977000561 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693977000562 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693977000563 homodimer interface [polypeptide binding]; other site 693977000564 catalytic residue [active] 693977000565 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 693977000566 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 693977000567 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 693977000568 putative acetyltransferase; Provisional; Region: PRK03624 693977000569 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693977000570 Coenzyme A binding pocket [chemical binding]; other site 693977000571 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 693977000572 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 693977000573 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 693977000574 catalytic site [active] 693977000575 subunit interface [polypeptide binding]; other site 693977000576 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 693977000577 Domain of unknown function DUF11; Region: DUF11; cl17728 693977000578 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 693977000579 Domain of unknown function DUF11; Region: DUF11; pfam01345 693977000580 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 693977000581 putative active site [active] 693977000582 catalytic residue [active] 693977000583 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 693977000584 Archaeal/vacuolar-type H+-ATPase subunit I [Energy production and conversion]; Region: NtpI; COG1269 693977000585 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 693977000586 V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074 693977000587 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 693977000588 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 693977000589 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632 693977000590 V-type ATP synthase subunit A; Provisional; Region: PRK04192 693977000591 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 693977000592 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 693977000593 Walker A motif/ATP binding site; other site 693977000594 Walker B motif; other site 693977000595 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 693977000596 V-type ATP synthase subunit B; Provisional; Region: PRK04196 693977000597 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 693977000598 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 693977000599 Walker A motif homologous position; other site 693977000600 Walker B motif; other site 693977000601 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 693977000602 Archaeal/vacuolar-type H+-ATPase subunit D [Energy production and conversion]; Region: NtpD; COG1394 693977000603 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 693977000604 TrkA-N domain; Region: TrkA_N; pfam02254 693977000605 TrkA-C domain; Region: TrkA_C; pfam02080 693977000606 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 693977000607 Beta-lactamase; Region: Beta-lactamase; pfam00144 693977000608 Cation transport protein; Region: TrkH; cl17365 693977000609 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 693977000610 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 693977000611 LysE type translocator; Region: LysE; cl00565 693977000612 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 693977000613 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 693977000614 active site 693977000615 catalytic site [active] 693977000616 substrate binding site [chemical binding]; other site 693977000617 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 693977000618 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 693977000619 propionate/acetate kinase; Provisional; Region: PRK12379 693977000620 phosphate acetyltransferase; Reviewed; Region: PRK05632 693977000621 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693977000622 DRTGG domain; Region: DRTGG; pfam07085 693977000623 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 693977000624 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 693977000625 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 693977000626 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693977000627 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 693977000628 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 693977000629 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 693977000630 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 693977000631 GAF domain; Region: GAF_2; pfam13185 693977000632 GAF domain; Region: GAF_3; pfam13492 693977000633 Histidine kinase; Region: HisKA_3; pfam07730 693977000634 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 693977000635 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693977000636 ATP binding site [chemical binding]; other site 693977000637 Mg2+ binding site [ion binding]; other site 693977000638 G-X-G motif; other site 693977000639 Protein of unknown function (DUF3809); Region: DUF3809; pfam12723 693977000640 Protein of unknown function (DUF3248); Region: DUF3248; pfam11609 693977000641 phosphoribosylamine--glycine ligase; Region: purD; TIGR00877 693977000642 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 693977000643 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 693977000644 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 693977000645 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693977000646 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 693977000647 active site 693977000648 catalytic motif [active] 693977000649 Zn binding site [ion binding]; other site 693977000650 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 693977000651 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 693977000652 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 693977000653 Competence protein; Region: Competence; pfam03772 693977000654 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 693977000655 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693977000656 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 693977000657 Peptidase family M28; Region: Peptidase_M28; pfam04389 693977000658 metal binding site [ion binding]; metal-binding site 693977000659 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 693977000660 endonuclease III; Region: ENDO3c; smart00478 693977000661 minor groove reading motif; other site 693977000662 helix-hairpin-helix signature motif; other site 693977000663 substrate binding pocket [chemical binding]; other site 693977000664 active site 693977000665 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 693977000666 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 693977000667 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 693977000668 Found in ATP-dependent protease La (LON); Region: LON; smart00464 693977000669 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693977000670 Walker A motif; other site 693977000671 ATP binding site [chemical binding]; other site 693977000672 Walker B motif; other site 693977000673 arginine finger; other site 693977000674 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 693977000675 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 693977000676 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 693977000677 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 693977000678 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693977000679 catalytic residue [active] 693977000680 AAA domain; Region: AAA_18; pfam13238 693977000681 SnoaL-like domain; Region: SnoaL_3; pfam13474 693977000682 Erythromycin esterase; Region: Erythro_esteras; cl17110 693977000683 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693977000684 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693977000685 non-specific DNA binding site [nucleotide binding]; other site 693977000686 salt bridge; other site 693977000687 sequence-specific DNA binding site [nucleotide binding]; other site 693977000688 glutaminyl-tRNA synthetase/YqeY domain fusion protein; Provisional; Region: PRK14703 693977000689 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 693977000690 active site 693977000691 HIGH motif; other site 693977000692 nucleotide binding site [chemical binding]; other site 693977000693 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 693977000694 KMSKS motif; other site 693977000695 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 693977000696 GatB domain; Region: GatB_Yqey; smart00845 693977000697 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 693977000698 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 693977000699 SPOC domain; Region: SPOC; pfam07744 693977000700 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 693977000701 Walker A motif; other site 693977000702 ATP binding site [chemical binding]; other site 693977000703 Walker B motif; other site 693977000704 monovalent cation/proton antiporter, MnhG/PhaG subunit; Region: CPA3_mnhG_phaG; TIGR01300 693977000705 Multisubunit Na+/H+ antiporter, MnhE subunit [Inorganic ion transport and metabolism]; Region: MnhE; COG1863 693977000706 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 693977000707 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 693977000708 Multicomponent Na+:H+ antiporter, MnhC subunit; Region: 2a6301s03; TIGR00941 693977000709 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 693977000710 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 693977000711 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 693977000712 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 693977000713 UV-endonuclease UvdE; Region: UvdE; cl10036 693977000714 Predicted helicase [General function prediction only]; Region: COG4889 693977000715 DDE superfamily endonuclease; Region: DDE_3; pfam13358 693977000716 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 693977000717 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 693977000718 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 693977000719 homodimer interface [polypeptide binding]; other site 693977000720 substrate-cofactor binding pocket; other site 693977000721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693977000722 catalytic residue [active] 693977000723 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 693977000724 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 693977000725 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 693977000726 Glutamine amidotransferase class-I; Region: GATase; pfam00117 693977000727 glutamine binding [chemical binding]; other site 693977000728 catalytic triad [active] 693977000729 Predicted transcriptional regulator [Transcription]; Region: COG1959 693977000730 Transcriptional regulator; Region: Rrf2; cl17282 693977000731 enoyl-CoA hydratase; Provisional; Region: PRK08140 693977000732 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693977000733 substrate binding site [chemical binding]; other site 693977000734 oxyanion hole (OAH) forming residues; other site 693977000735 trimer interface [polypeptide binding]; other site 693977000736 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 693977000737 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 693977000738 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 693977000739 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 693977000740 dimer interface [polypeptide binding]; other site 693977000741 acyl-activating enzyme (AAE) consensus motif; other site 693977000742 putative active site [active] 693977000743 AMP binding site [chemical binding]; other site 693977000744 putative CoA binding site [chemical binding]; other site 693977000745 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 693977000746 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 693977000747 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 693977000748 putative active site [active] 693977000749 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 693977000750 active site 693977000751 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693977000752 active site 693977000753 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 693977000754 homopentamer interface [polypeptide binding]; other site 693977000755 active site 693977000756 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 693977000757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 693977000758 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 693977000759 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 693977000760 G-X-X-G motif; other site 693977000761 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 693977000762 RxxxH motif; other site 693977000763 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 693977000764 classical (c) SDRs; Region: SDR_c; cd05233 693977000765 NAD(P) binding site [chemical binding]; other site 693977000766 active site 693977000767 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 693977000768 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 693977000769 TRAM domain; Region: TRAM; cl01282 693977000770 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 693977000771 active site 693977000772 oligomerization interface [polypeptide binding]; other site 693977000773 metal binding site [ion binding]; metal-binding site 693977000774 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 693977000775 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693977000776 motif II; other site 693977000777 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 693977000778 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 693977000779 ligand binding site [chemical binding]; other site 693977000780 flexible hinge region; other site 693977000781 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 693977000782 putative switch regulator; other site 693977000783 non-specific DNA interactions [nucleotide binding]; other site 693977000784 DNA binding site [nucleotide binding] 693977000785 sequence specific DNA binding site [nucleotide binding]; other site 693977000786 putative cAMP binding site [chemical binding]; other site 693977000787 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 693977000788 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 693977000789 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 693977000790 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693977000791 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693977000792 DNA binding residues [nucleotide binding] 693977000793 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693977000794 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693977000795 DNA binding site [nucleotide binding] 693977000796 domain linker motif; other site 693977000797 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 693977000798 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 693977000799 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 693977000800 active site residue [active] 693977000801 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 693977000802 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693977000803 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693977000804 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693977000805 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 693977000806 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693977000807 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 693977000808 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 693977000809 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 693977000810 TrkA-N domain; Region: TrkA_N; pfam02254 693977000811 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 693977000812 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 693977000813 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 693977000814 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 693977000815 G1 box; other site 693977000816 GTP/Mg2+ binding site [chemical binding]; other site 693977000817 G2 box; other site 693977000818 Switch I region; other site 693977000819 G3 box; other site 693977000820 Switch II region; other site 693977000821 G4 box; other site 693977000822 G5 box; other site 693977000823 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 693977000824 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 693977000825 E-class dimer interface [polypeptide binding]; other site 693977000826 P-class dimer interface [polypeptide binding]; other site 693977000827 active site 693977000828 Cu2+ binding site [ion binding]; other site 693977000829 Zn2+ binding site [ion binding]; other site 693977000830 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 693977000831 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 693977000832 E-class dimer interface [polypeptide binding]; other site 693977000833 P-class dimer interface [polypeptide binding]; other site 693977000834 active site 693977000835 Cu2+ binding site [ion binding]; other site 693977000836 Zn2+ binding site [ion binding]; other site 693977000837 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 693977000838 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 693977000839 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 693977000840 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 693977000841 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 693977000842 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 693977000843 VanW like protein; Region: VanW; pfam04294 693977000844 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 693977000845 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 693977000846 active site 693977000847 Riboflavin kinase; Region: Flavokinase; pfam01687 693977000848 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 693977000849 dimer interface [polypeptide binding]; other site 693977000850 ADP-ribose binding site [chemical binding]; other site 693977000851 active site 693977000852 nudix motif; other site 693977000853 metal binding site [ion binding]; metal-binding site 693977000854 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 693977000855 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693977000856 Zn2+ binding site [ion binding]; other site 693977000857 Mg2+ binding site [ion binding]; other site 693977000858 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 693977000859 Ion transport protein; Region: Ion_trans; pfam00520 693977000860 Ion channel; Region: Ion_trans_2; pfam07885 693977000861 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 693977000862 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 693977000863 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 693977000864 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 693977000865 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 693977000866 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 693977000867 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 693977000868 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 693977000869 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 693977000870 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 693977000871 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 693977000872 active site 693977000873 Tetratricopeptide repeat; Region: TPR_12; pfam13424 693977000874 Tetratricopeptide repeat; Region: TPR_12; pfam13424 693977000875 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693977000876 binding surface 693977000877 TPR motif; other site 693977000878 Tetratricopeptide repeat; Region: TPR_12; pfam13424 693977000879 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693977000880 binding surface 693977000881 TPR motif; other site 693977000882 Tetratricopeptide repeat; Region: TPR_12; pfam13424 693977000883 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693977000884 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693977000885 metal binding site [ion binding]; metal-binding site 693977000886 active site 693977000887 I-site; other site 693977000888 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693977000889 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 693977000890 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 693977000891 generic binding surface II; other site 693977000892 generic binding surface I; other site 693977000893 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693977000894 Coenzyme A binding pocket [chemical binding]; other site 693977000895 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 693977000896 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693977000897 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 693977000898 Chorismate mutase type II; Region: CM_2; cl00693 693977000899 prephenate dehydrogenase; Validated; Region: PRK08507 693977000900 Chorismate mutase type II; Region: CM_2; cl00693 693977000901 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 693977000902 Prephenate dehydratase; Region: PDT; pfam00800 693977000903 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 693977000904 putative L-Phe binding site [chemical binding]; other site 693977000905 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 693977000906 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 693977000907 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 693977000908 active site residue [active] 693977000909 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 693977000910 active site residue [active] 693977000911 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 693977000912 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 693977000913 active site 693977000914 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 693977000915 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 693977000916 putative substrate binding region [chemical binding]; other site 693977000917 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 693977000918 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 693977000919 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 693977000920 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 693977000921 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 693977000922 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 693977000923 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 693977000924 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 693977000925 PYR/PP interface [polypeptide binding]; other site 693977000926 dimer interface [polypeptide binding]; other site 693977000927 TPP binding site [chemical binding]; other site 693977000928 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 693977000929 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 693977000930 TPP-binding site [chemical binding]; other site 693977000931 dimer interface [polypeptide binding]; other site 693977000932 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 693977000933 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 693977000934 putative valine binding site [chemical binding]; other site 693977000935 dimer interface [polypeptide binding]; other site 693977000936 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 693977000937 ketol-acid reductoisomerase; Provisional; Region: PRK05479 693977000938 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 693977000939 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 693977000940 threonine dehydratase; Reviewed; Region: PRK09224 693977000941 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 693977000942 tetramer interface [polypeptide binding]; other site 693977000943 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693977000944 catalytic residue [active] 693977000945 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 693977000946 putative Ile/Val binding site [chemical binding]; other site 693977000947 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 693977000948 putative Ile/Val binding site [chemical binding]; other site 693977000949 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 693977000950 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 693977000951 ribosome recycling factor; Reviewed; Region: frr; PRK00083 693977000952 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 693977000953 hinge region; other site 693977000954 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 693977000955 putative nucleotide binding site [chemical binding]; other site 693977000956 uridine monophosphate binding site [chemical binding]; other site 693977000957 homohexameric interface [polypeptide binding]; other site 693977000958 elongation factor Ts; Provisional; Region: tsf; PRK09377 693977000959 UBA/TS-N domain; Region: UBA; pfam00627 693977000960 Elongation factor TS; Region: EF_TS; pfam00889 693977000961 Elongation factor TS; Region: EF_TS; pfam00889 693977000962 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 693977000963 rRNA interaction site [nucleotide binding]; other site 693977000964 S8 interaction site; other site 693977000965 putative laminin-1 binding site; other site 693977000966 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 693977000967 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693977000968 S-adenosylmethionine binding site [chemical binding]; other site 693977000969 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 693977000970 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 693977000971 active site 693977000972 (T/H)XGH motif; other site 693977000973 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 693977000974 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693977000975 dimer interface [polypeptide binding]; other site 693977000976 phosphorylation site [posttranslational modification] 693977000977 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693977000978 ATP binding site [chemical binding]; other site 693977000979 Mg2+ binding site [ion binding]; other site 693977000980 G-X-G motif; other site 693977000981 Response regulator receiver domain; Region: Response_reg; pfam00072 693977000982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693977000983 active site 693977000984 phosphorylation site [posttranslational modification] 693977000985 intermolecular recognition site; other site 693977000986 dimerization interface [polypeptide binding]; other site 693977000987 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 693977000988 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 693977000989 Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Region: RpsF; COG0360 693977000990 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 693977000991 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 693977000992 dimer interface [polypeptide binding]; other site 693977000993 ssDNA binding site [nucleotide binding]; other site 693977000994 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693977000995 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 693977000996 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 693977000997 dimer interface [polypeptide binding]; other site 693977000998 ssDNA binding site [nucleotide binding]; other site 693977000999 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693977001000 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 693977001001 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 693977001002 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 693977001003 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 693977001004 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 693977001005 Domain of unknown function DUF21; Region: DUF21; pfam01595 693977001006 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 693977001007 Transporter associated domain; Region: CorC_HlyC; smart01091 693977001008 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 693977001009 Domain of unknown function DUF21; Region: DUF21; pfam01595 693977001010 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 693977001011 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 693977001012 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 693977001013 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 693977001014 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 693977001015 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 693977001016 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 693977001017 oligomer interface [polypeptide binding]; other site 693977001018 recombination factor protein RarA; Reviewed; Region: PRK13342 693977001019 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693977001020 Walker A motif; other site 693977001021 ATP binding site [chemical binding]; other site 693977001022 Walker B motif; other site 693977001023 arginine finger; other site 693977001024 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 693977001025 elongation factor Tu; Reviewed; Region: PRK00049 693977001026 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 693977001027 G1 box; other site 693977001028 GEF interaction site [polypeptide binding]; other site 693977001029 GTP/Mg2+ binding site [chemical binding]; other site 693977001030 Switch I region; other site 693977001031 G2 box; other site 693977001032 G3 box; other site 693977001033 Switch II region; other site 693977001034 G4 box; other site 693977001035 G5 box; other site 693977001036 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 693977001037 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 693977001038 Antibiotic Binding Site [chemical binding]; other site 693977001039 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 693977001040 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 693977001041 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 693977001042 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 693977001043 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 693977001044 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 693977001045 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 693977001046 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 693977001047 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 693977001048 putative translocon binding site; other site 693977001049 protein-rRNA interface [nucleotide binding]; other site 693977001050 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 693977001051 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 693977001052 G-X-X-G motif; other site 693977001053 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 693977001054 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 693977001055 23S rRNA interface [nucleotide binding]; other site 693977001056 5S rRNA interface [nucleotide binding]; other site 693977001057 putative antibiotic binding site [chemical binding]; other site 693977001058 L25 interface [polypeptide binding]; other site 693977001059 L27 interface [polypeptide binding]; other site 693977001060 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 693977001061 23S rRNA interface [nucleotide binding]; other site 693977001062 putative translocon interaction site; other site 693977001063 signal recognition particle (SRP54) interaction site; other site 693977001064 L23 interface [polypeptide binding]; other site 693977001065 trigger factor interaction site; other site 693977001066 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 693977001067 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 693977001068 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 693977001069 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 693977001070 RNA binding site [nucleotide binding]; other site 693977001071 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 693977001072 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 693977001073 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 693977001074 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 693977001075 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 693977001076 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 693977001077 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 693977001078 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 693977001079 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 693977001080 5S rRNA interface [nucleotide binding]; other site 693977001081 23S rRNA interface [nucleotide binding]; other site 693977001082 L5 interface [polypeptide binding]; other site 693977001083 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 693977001084 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 693977001085 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 693977001086 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 693977001087 23S rRNA binding site [nucleotide binding]; other site 693977001088 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 693977001089 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 693977001090 SecY translocase; Region: SecY; pfam00344 693977001091 adenylate kinase; Provisional; Region: PRK14527 693977001092 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 693977001093 AMP-binding site [chemical binding]; other site 693977001094 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 693977001095 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 693977001096 rRNA binding site [nucleotide binding]; other site 693977001097 predicted 30S ribosome binding site; other site 693977001098 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 693977001099 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 693977001100 30S ribosomal protein S13; Region: bact_S13; TIGR03631 693977001101 30S ribosomal protein S11; Validated; Region: PRK05309 693977001102 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 693977001103 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 693977001104 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693977001105 RNA binding surface [nucleotide binding]; other site 693977001106 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 693977001107 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 693977001108 alphaNTD - beta interaction site [polypeptide binding]; other site 693977001109 alphaNTD homodimer interface [polypeptide binding]; other site 693977001110 alphaNTD - beta' interaction site [polypeptide binding]; other site 693977001111 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 693977001112 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 693977001113 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 693977001114 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 693977001115 catalytic residues [active] 693977001116 Uncharacterized conserved protein [Function unknown]; Region: COG1432 693977001117 LabA_like proteins; Region: LabA; cd10911 693977001118 putative metal binding site [ion binding]; other site 693977001119 putative phosphate acyltransferase; Provisional; Region: PRK05331 693977001120 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 693977001121 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693977001122 Walker A motif; other site 693977001123 ATP binding site [chemical binding]; other site 693977001124 Walker B motif; other site 693977001125 arginine finger; other site 693977001126 Peptidase family M41; Region: Peptidase_M41; pfam01434 693977001127 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 693977001128 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 693977001129 homodimer interface [polypeptide binding]; other site 693977001130 metal binding site [ion binding]; metal-binding site 693977001131 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 693977001132 Glycoprotease family; Region: Peptidase_M22; pfam00814 693977001133 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 693977001134 dimer interface [polypeptide binding]; other site 693977001135 Citrate synthase; Region: Citrate_synt; pfam00285 693977001136 active site 693977001137 coenzyme A binding site [chemical binding]; other site 693977001138 citrylCoA binding site [chemical binding]; other site 693977001139 oxalacetate/citrate binding site [chemical binding]; other site 693977001140 catalytic triad [active] 693977001141 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 693977001142 active site 693977001143 metal binding site [ion binding]; metal-binding site 693977001144 homotetramer interface [polypeptide binding]; other site 693977001145 PQQ-like domain; Region: PQQ_2; pfam13360 693977001146 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 693977001147 Trp docking motif [polypeptide binding]; other site 693977001148 active site 693977001149 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 693977001150 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 693977001151 active site turn [active] 693977001152 phosphorylation site [posttranslational modification] 693977001153 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 693977001154 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 693977001155 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 693977001156 Ca binding site [ion binding]; other site 693977001157 active site 693977001158 catalytic site [active] 693977001159 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 693977001160 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 693977001161 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 693977001162 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 693977001163 active site 693977001164 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 693977001165 Peptidase family M50; Region: Peptidase_M50; pfam02163 693977001166 active site 693977001167 putative substrate binding region [chemical binding]; other site 693977001168 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 693977001169 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 693977001170 active site 693977001171 NTP binding site [chemical binding]; other site 693977001172 metal binding triad [ion binding]; metal-binding site 693977001173 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 693977001174 putative active site [active] 693977001175 putative catalytic site [active] 693977001176 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 693977001177 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 693977001178 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 693977001179 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 693977001180 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 693977001181 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 693977001182 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 693977001183 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 693977001184 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 693977001185 active site 693977001186 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 693977001187 homotrimer interaction site [polypeptide binding]; other site 693977001188 putative active site [active] 693977001189 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 693977001190 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 693977001191 putative active site; other site 693977001192 catalytic triad [active] 693977001193 putative dimer interface [polypeptide binding]; other site 693977001194 Arginase family; Region: Arginase; cd09989 693977001195 agmatinase; Region: agmatinase; TIGR01230 693977001196 active site 693977001197 Mn binding site [ion binding]; other site 693977001198 oligomer interface [polypeptide binding]; other site 693977001199 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231; cd11544 693977001200 homodimer interface [polypeptide binding]; other site 693977001201 active site 693977001202 metal binding site [ion binding]; metal-binding site 693977001203 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 693977001204 catalytic core [active] 693977001205 hypothetical protein; Provisional; Region: PRK02947 693977001206 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 693977001207 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 693977001208 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 693977001209 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 693977001210 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 693977001211 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693977001212 substrate binding site [chemical binding]; other site 693977001213 oxyanion hole (OAH) forming residues; other site 693977001214 trimer interface [polypeptide binding]; other site 693977001215 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693977001216 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693977001217 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 693977001218 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 693977001219 dimer interface [polypeptide binding]; other site 693977001220 active site 693977001221 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 693977001222 Protein of unknown function (DUF968); Region: DUF968; pfam06147 693977001223 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693977001224 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 693977001225 structural tetrad; other site 693977001226 FOG: WD40 repeat [General function prediction only]; Region: COG2319 693977001227 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 693977001228 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 693977001229 FAD binding domain; Region: FAD_binding_4; pfam01565 693977001230 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 693977001231 PUA domain; Region: PUA; cl00607 693977001232 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 693977001233 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 693977001234 putative RNA binding site [nucleotide binding]; other site 693977001235 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693977001236 S-adenosylmethionine binding site [chemical binding]; other site 693977001237 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 693977001238 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693977001239 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 693977001240 Walker A/P-loop; other site 693977001241 ATP binding site [chemical binding]; other site 693977001242 Q-loop/lid; other site 693977001243 ABC transporter signature motif; other site 693977001244 Walker B; other site 693977001245 D-loop; other site 693977001246 H-loop/switch region; other site 693977001247 hypothetical protein; Provisional; Region: PRK06753 693977001248 hypothetical protein; Provisional; Region: PRK07236 693977001249 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 693977001250 FAD binding domain; Region: FAD_binding_4; pfam01565 693977001251 isocitrate dehydrogenase; Validated; Region: PRK07362 693977001252 isocitrate dehydrogenase; Reviewed; Region: PRK07006 693977001253 DinB superfamily; Region: DinB_2; pfam12867 693977001254 GTPase Era; Reviewed; Region: era; PRK00089 693977001255 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 693977001256 G1 box; other site 693977001257 GTP/Mg2+ binding site [chemical binding]; other site 693977001258 Switch I region; other site 693977001259 G2 box; other site 693977001260 Switch II region; other site 693977001261 G3 box; other site 693977001262 G4 box; other site 693977001263 G5 box; other site 693977001264 KH domain; Region: KH_2; pfam07650 693977001265 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 693977001266 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 693977001267 dimerization interface 3.5A [polypeptide binding]; other site 693977001268 active site 693977001269 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 693977001270 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 693977001271 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 693977001272 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 693977001273 GTPase CgtA; Reviewed; Region: obgE; PRK12297 693977001274 GTP1/OBG; Region: GTP1_OBG; pfam01018 693977001275 Obg GTPase; Region: Obg; cd01898 693977001276 G1 box; other site 693977001277 GTP/Mg2+ binding site [chemical binding]; other site 693977001278 Switch I region; other site 693977001279 G2 box; other site 693977001280 G3 box; other site 693977001281 Switch II region; other site 693977001282 G4 box; other site 693977001283 G5 box; other site 693977001284 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 693977001285 Predicted permeases [General function prediction only]; Region: COG0795 693977001286 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 693977001287 Predicted permeases [General function prediction only]; Region: COG0795 693977001288 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 693977001289 Domain of unknown function (DUF4403); Region: DUF4403; pfam14356 693977001290 seryl-tRNA synthetase; Provisional; Region: PRK05431 693977001291 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 693977001292 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 693977001293 dimer interface [polypeptide binding]; other site 693977001294 active site 693977001295 motif 1; other site 693977001296 motif 2; other site 693977001297 motif 3; other site 693977001298 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 693977001299 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 693977001300 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 693977001301 Thioredoxin; Region: Thioredoxin_4; pfam13462 693977001302 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 693977001303 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 693977001304 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 693977001305 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 693977001306 hypothetical protein; Provisional; Region: PRK12705 693977001307 KH domain; Region: KH_1; pfam00013 693977001308 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693977001309 Zn2+ binding site [ion binding]; other site 693977001310 Mg2+ binding site [ion binding]; other site 693977001311 CHASE3 domain; Region: CHASE3; pfam05227 693977001312 GAF domain; Region: GAF_3; pfam13492 693977001313 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693977001314 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693977001315 metal binding site [ion binding]; metal-binding site 693977001316 active site 693977001317 I-site; other site 693977001318 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 693977001319 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 693977001320 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 693977001321 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 693977001322 CTP synthetase; Validated; Region: pyrG; PRK05380 693977001323 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 693977001324 Catalytic site [active] 693977001325 active site 693977001326 UTP binding site [chemical binding]; other site 693977001327 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 693977001328 active site 693977001329 putative oxyanion hole; other site 693977001330 catalytic triad [active] 693977001331 malate dehydrogenase; Provisional; Region: PRK13529 693977001332 Malic enzyme, N-terminal domain; Region: malic; pfam00390 693977001333 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 693977001334 NAD(P) binding pocket [chemical binding]; other site 693977001335 Predicted thioesterase [General function prediction only]; Region: COG5496 693977001336 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 693977001337 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 693977001338 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 693977001339 active site 693977001340 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 693977001341 ADP-ribose binding site [chemical binding]; other site 693977001342 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 693977001343 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 693977001344 catalytic site [active] 693977001345 G-X2-G-X-G-K; other site 693977001346 Uncharacterized conserved protein [Function unknown]; Region: COG2013 693977001347 Hemerythrin; Region: Hemerythrin; cd12107 693977001348 Fe binding site [ion binding]; other site 693977001349 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 693977001350 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 693977001351 TPP-binding site [chemical binding]; other site 693977001352 dimer interface [polypeptide binding]; other site 693977001353 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 693977001354 PYR/PP interface [polypeptide binding]; other site 693977001355 dimer interface [polypeptide binding]; other site 693977001356 TPP binding site [chemical binding]; other site 693977001357 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 693977001358 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693977001359 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693977001360 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 693977001361 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 693977001362 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693977001363 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 693977001364 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 693977001365 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693977001366 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 693977001367 BON domain; Region: BON; pfam04972 693977001368 argininosuccinate synthase; Provisional; Region: PRK13820 693977001369 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 693977001370 ANP binding site [chemical binding]; other site 693977001371 Substrate Binding Site II [chemical binding]; other site 693977001372 Substrate Binding Site I [chemical binding]; other site 693977001373 argininosuccinate lyase; Provisional; Region: PRK00855 693977001374 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 693977001375 active sites [active] 693977001376 tetramer interface [polypeptide binding]; other site 693977001377 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cl00254 693977001378 active site 693977001379 dimer interface [polypeptide binding]; other site 693977001380 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 693977001381 PA/protease or protease-like domain interface [polypeptide binding]; other site 693977001382 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 693977001383 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693977001384 active site 693977001385 motif I; other site 693977001386 motif II; other site 693977001387 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 693977001388 RibD C-terminal domain; Region: RibD_C; cl17279 693977001389 excinuclease ABC subunit B; Provisional; Region: PRK05298 693977001390 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693977001391 ATP binding site [chemical binding]; other site 693977001392 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693977001393 nucleotide binding region [chemical binding]; other site 693977001394 ATP-binding site [chemical binding]; other site 693977001395 Ultra-violet resistance protein B; Region: UvrB; pfam12344 693977001396 UvrB/uvrC motif; Region: UVR; pfam02151 693977001397 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 693977001398 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 693977001399 active site 693977001400 metal binding site [ion binding]; metal-binding site 693977001401 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 693977001402 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 693977001403 Predicted permeases [General function prediction only]; Region: COG0795 693977001404 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 693977001405 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 693977001406 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 693977001407 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 693977001408 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 693977001409 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 693977001410 NodB motif; other site 693977001411 putative active site [active] 693977001412 putative catalytic site [active] 693977001413 putative Zn binding site [ion binding]; other site 693977001414 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 693977001415 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 693977001416 Predicted transcriptional regulators [Transcription]; Region: COG1695 693977001417 Transcriptional regulator PadR-like family; Region: PadR; cl17335 693977001418 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 693977001419 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14358 693977001420 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 693977001421 Substrate binding site; other site 693977001422 Mg++ binding site; other site 693977001423 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 693977001424 active site 693977001425 substrate binding site [chemical binding]; other site 693977001426 CoA binding site [chemical binding]; other site 693977001427 hypothetical protein; Provisional; Region: PRK10621 693977001428 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 693977001429 Protein of unknown function (DUF2847); Region: DUF2847; cl17683 693977001430 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693977001431 dimerization interface [polypeptide binding]; other site 693977001432 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 693977001433 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693977001434 Zn2+ binding site [ion binding]; other site 693977001435 Mg2+ binding site [ion binding]; other site 693977001436 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 693977001437 synthetase active site [active] 693977001438 NTP binding site [chemical binding]; other site 693977001439 metal binding site [ion binding]; metal-binding site 693977001440 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 693977001441 ACT domain; Region: ACT_4; pfam13291 693977001442 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 693977001443 RNA/DNA hybrid binding site [nucleotide binding]; other site 693977001444 active site 693977001445 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 693977001446 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 693977001447 putative active site [active] 693977001448 catalytic site [active] 693977001449 putative metal binding site [ion binding]; other site 693977001450 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 693977001451 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 693977001452 2-isopropylmalate synthase; Validated; Region: PRK00915 693977001453 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 693977001454 active site 693977001455 catalytic residues [active] 693977001456 metal binding site [ion binding]; metal-binding site 693977001457 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 693977001458 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 693977001459 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 693977001460 substrate binding site [chemical binding]; other site 693977001461 ligand binding site [chemical binding]; other site 693977001462 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 693977001463 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 693977001464 substrate binding site [chemical binding]; other site 693977001465 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 693977001466 tartrate dehydrogenase; Region: TTC; TIGR02089 693977001467 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 693977001468 dimerization interface [polypeptide binding]; other site 693977001469 putative DNA binding site [nucleotide binding]; other site 693977001470 putative Zn2+ binding site [ion binding]; other site 693977001471 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 693977001472 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 693977001473 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 693977001474 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 693977001475 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 693977001476 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 693977001477 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693977001478 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 693977001479 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 693977001480 catalytic residues [active] 693977001481 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 693977001482 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 693977001483 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 693977001484 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 693977001485 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 693977001486 putative substrate binding site [chemical binding]; other site 693977001487 putative ATP binding site [chemical binding]; other site 693977001488 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693977001489 binding surface 693977001490 TPR motif; other site 693977001491 TPR repeat; Region: TPR_11; pfam13414 693977001492 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 693977001493 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 693977001494 Predicted dehydrogenase [General function prediction only]; Region: COG5322 693977001495 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 693977001496 NAD(P) binding pocket [chemical binding]; other site 693977001497 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 693977001498 putative active site [active] 693977001499 catalytic site [active] 693977001500 PLD-like domain; Region: PLDc_2; pfam13091 693977001501 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138 693977001502 putative active site [active] 693977001503 catalytic site [active] 693977001504 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 693977001505 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 693977001506 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 693977001507 Stage II sporulation protein; Region: SpoIID; pfam08486 693977001508 Methyltransferase domain; Region: Methyltransf_31; pfam13847 693977001509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693977001510 S-adenosylmethionine binding site [chemical binding]; other site 693977001511 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693977001512 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693977001513 Coenzyme A binding pocket [chemical binding]; other site 693977001514 arginine decarboxylase; Provisional; Region: PRK05354 693977001515 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 693977001516 dimer interface [polypeptide binding]; other site 693977001517 active site 693977001518 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693977001519 catalytic residues [active] 693977001520 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 693977001521 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 693977001522 dimer interface [polypeptide binding]; other site 693977001523 substrate binding site [chemical binding]; other site 693977001524 metal binding site [ion binding]; metal-binding site 693977001525 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 693977001526 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 693977001527 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693977001528 active site 693977001529 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 693977001530 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 693977001531 active site 693977001532 active site 693977001533 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 693977001534 [2Fe-2S] cluster binding site [ion binding]; other site 693977001535 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 693977001536 metal binding site [ion binding]; metal-binding site 693977001537 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 693977001538 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 693977001539 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 693977001540 acyl-activating enzyme (AAE) consensus motif; other site 693977001541 AMP binding site [chemical binding]; other site 693977001542 active site 693977001543 CoA binding site [chemical binding]; other site 693977001544 chaperone protein DnaJ; Provisional; Region: PRK14292 693977001545 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 693977001546 HSP70 interaction site [polypeptide binding]; other site 693977001547 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 693977001548 Zn binding sites [ion binding]; other site 693977001549 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 693977001550 dimer interface [polypeptide binding]; other site 693977001551 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 693977001552 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 693977001553 active site 693977001554 HIGH motif; other site 693977001555 dimer interface [polypeptide binding]; other site 693977001556 KMSKS motif; other site 693977001557 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 693977001558 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 693977001559 NAD(P) binding site [chemical binding]; other site 693977001560 futalosine nucleosidase; Region: fut_nucase; TIGR03664 693977001561 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 693977001562 Protein of unknown function DUF58; Region: DUF58; pfam01882 693977001563 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 693977001564 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 693977001565 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 693977001566 MoxR-like ATPases [General function prediction only]; Region: COG0714 693977001567 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 693977001568 Walker B motif; other site 693977001569 arginine finger; other site 693977001570 short chain dehydrogenase; Provisional; Region: PRK06701 693977001571 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 693977001572 NAD binding site [chemical binding]; other site 693977001573 metal binding site [ion binding]; metal-binding site 693977001574 active site 693977001575 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 693977001576 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 693977001577 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 693977001578 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 693977001579 active site 693977001580 catalytic site [active] 693977001581 diaminopimelate decarboxylase; Region: lysA; TIGR01048 693977001582 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 693977001583 active site 693977001584 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693977001585 substrate binding site [chemical binding]; other site 693977001586 catalytic residues [active] 693977001587 dimer interface [polypeptide binding]; other site 693977001588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 693977001589 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 693977001590 SET and RING finger associated domain; Region: SRA; smart00466 693977001591 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 693977001592 active site 693977001593 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 693977001594 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 693977001595 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693977001596 ATP binding site [chemical binding]; other site 693977001597 putative Mg++ binding site [ion binding]; other site 693977001598 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693977001599 nucleotide binding region [chemical binding]; other site 693977001600 ATP-binding site [chemical binding]; other site 693977001601 TRCF domain; Region: TRCF; pfam03461 693977001602 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 693977001603 amino acid carrier protein; Region: agcS; TIGR00835 693977001604 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 693977001605 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 693977001606 NAD binding site [chemical binding]; other site 693977001607 ligand binding site [chemical binding]; other site 693977001608 catalytic site [active] 693977001609 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 693977001610 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693977001611 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 693977001612 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 693977001613 Walker A/P-loop; other site 693977001614 ATP binding site [chemical binding]; other site 693977001615 Q-loop/lid; other site 693977001616 ABC transporter signature motif; other site 693977001617 Walker B; other site 693977001618 D-loop; other site 693977001619 H-loop/switch region; other site 693977001620 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 693977001621 putative ligand binding site [chemical binding]; other site 693977001622 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 693977001623 active site 693977001624 catalytic residues [active] 693977001625 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 693977001626 Catalytic domain of Protein Kinases; Region: PKc; cd00180 693977001627 active site 693977001628 ATP binding site [chemical binding]; other site 693977001629 substrate binding site [chemical binding]; other site 693977001630 activation loop (A-loop); other site 693977001631 Transcriptional regulator [Transcription]; Region: LytR; COG1316 693977001632 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 693977001633 H+ Antiporter protein; Region: 2A0121; TIGR00900 693977001634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693977001635 putative substrate translocation pore; other site 693977001636 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 693977001637 active site 693977001638 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 693977001639 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 693977001640 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 693977001641 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 693977001642 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 693977001643 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 693977001644 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693977001645 catalytic residue [active] 693977001646 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14468 693977001647 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693977001648 FeS/SAM binding site; other site 693977001649 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 693977001650 PEGA domain; Region: PEGA; pfam08308 693977001651 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 693977001652 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 693977001653 3D domain; Region: 3D; cl01439 693977001654 Protein of unknown function (DUF423); Region: DUF423; cl01008 693977001655 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 693977001656 SmpB-tmRNA interface; other site 693977001657 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 693977001658 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 693977001659 active site 693977001660 Sporulation and spore germination; Region: Germane; pfam10646 693977001661 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693977001662 Walker A/P-loop; other site 693977001663 ATP binding site [chemical binding]; other site 693977001664 Q-loop/lid; other site 693977001665 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 693977001666 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 693977001667 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 693977001668 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 693977001669 Q-loop/lid; other site 693977001670 ABC transporter signature motif; other site 693977001671 Walker B; other site 693977001672 D-loop; other site 693977001673 H-loop/switch region; other site 693977001674 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 693977001675 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 693977001676 putative active site [active] 693977001677 metal binding site [ion binding]; metal-binding site 693977001678 homodimer binding site [polypeptide binding]; other site 693977001679 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 693977001680 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693977001681 Walker A motif; other site 693977001682 ATP binding site [chemical binding]; other site 693977001683 Walker B motif; other site 693977001684 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693977001685 Walker A motif; other site 693977001686 ATP binding site [chemical binding]; other site 693977001687 Walker B motif; other site 693977001688 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 693977001689 MarR family; Region: MarR_2; pfam12802 693977001690 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 693977001691 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 693977001692 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 693977001693 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 693977001694 putative NADP binding site [chemical binding]; other site 693977001695 putative substrate binding site [chemical binding]; other site 693977001696 active site 693977001697 Uncharacterized conserved protein [Function unknown]; Region: COG2127 693977001698 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693977001699 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 693977001700 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 693977001701 GatB domain; Region: GatB_Yqey; smart00845 693977001702 CAAX protease self-immunity; Region: Abi; pfam02517 693977001703 Protein of unknown function (DUF456); Region: DUF456; cl01069 693977001704 putative acyltransferase; Provisional; Region: PRK05790 693977001705 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 693977001706 dimer interface [polypeptide binding]; other site 693977001707 active site 693977001708 YCII-related domain; Region: YCII; cl00999 693977001709 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 693977001710 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 693977001711 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 693977001712 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 693977001713 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693977001714 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 693977001715 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 693977001716 G1 box; other site 693977001717 putative GEF interaction site [polypeptide binding]; other site 693977001718 GTP/Mg2+ binding site [chemical binding]; other site 693977001719 Switch I region; other site 693977001720 G2 box; other site 693977001721 G3 box; other site 693977001722 Switch II region; other site 693977001723 G4 box; other site 693977001724 G5 box; other site 693977001725 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 693977001726 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 693977001727 Uncharacterized conserved protein [Function unknown]; Region: COG3342 693977001728 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 693977001729 Putative peptidoglycan binding domain; Region: PG_binding_2; pfam08823 693977001730 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 693977001731 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 693977001732 ligand binding site; other site 693977001733 oligomer interface; other site 693977001734 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 693977001735 dimer interface [polypeptide binding]; other site 693977001736 N-terminal domain interface [polypeptide binding]; other site 693977001737 sulfate 1 binding site; other site 693977001738 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 693977001739 tRNA dimethylallyltransferase; Region: miaA; TIGR00174 693977001740 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 693977001741 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 693977001742 putative dimer interface [polypeptide binding]; other site 693977001743 S4 domain; Region: S4_2; pfam13275 693977001744 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 693977001745 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 693977001746 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693977001747 active site 693977001748 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 693977001749 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 693977001750 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 693977001751 Tetramer interface [polypeptide binding]; other site 693977001752 active site 693977001753 FMN-binding site [chemical binding]; other site 693977001754 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 693977001755 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 693977001756 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 693977001757 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 693977001758 Pilus assembly protein, PilO; Region: PilO; cl01234 693977001759 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 693977001760 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 693977001761 Cell division protein FtsA; Region: FtsA; cl17206 693977001762 Cell division protein FtsA; Region: FtsA; cl17206 693977001763 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 693977001764 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 693977001765 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693977001766 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693977001767 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 693977001768 DAK2 domain; Region: Dak2; pfam02734 693977001769 Asp23 family; Region: Asp23; pfam03780 693977001770 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 693977001771 Moco binding site; other site 693977001772 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 693977001773 metal coordination site [ion binding]; other site 693977001774 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 693977001775 active site 693977001776 SUMO-1 interface [polypeptide binding]; other site 693977001777 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 693977001778 Maf-like protein; Provisional; Region: PRK14361 693977001779 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 693977001780 active site 693977001781 dimer interface [polypeptide binding]; other site 693977001782 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693977001783 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 693977001784 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 693977001785 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 693977001786 Sulfate transporter family; Region: Sulfate_transp; pfam00916 693977001787 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 693977001788 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 693977001789 intersubunit interface [polypeptide binding]; other site 693977001790 active site 693977001791 catalytic residue [active] 693977001792 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 693977001793 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 693977001794 catalytic triad [active] 693977001795 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 693977001796 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693977001797 active site 693977001798 dimer interface [polypeptide binding]; other site 693977001799 GMP synthase; Reviewed; Region: guaA; PRK00074 693977001800 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 693977001801 AMP/PPi binding site [chemical binding]; other site 693977001802 candidate oxyanion hole; other site 693977001803 catalytic triad [active] 693977001804 potential glutamine specificity residues [chemical binding]; other site 693977001805 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 693977001806 ATP Binding subdomain [chemical binding]; other site 693977001807 Ligand Binding sites [chemical binding]; other site 693977001808 Dimerization subdomain; other site 693977001809 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 693977001810 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 693977001811 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 693977001812 metal ion-dependent adhesion site (MIDAS); other site 693977001813 Phosphotransferase enzyme family; Region: APH; pfam01636 693977001814 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 693977001815 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 693977001816 DHH family; Region: DHH; pfam01368 693977001817 DHHA1 domain; Region: DHHA1; pfam02272 693977001818 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 693977001819 dimer interface [polypeptide binding]; other site 693977001820 active site 693977001821 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 693977001822 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 693977001823 ScpA/B protein; Region: ScpA_ScpB; cl00598 693977001824 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 693977001825 PRC-barrel domain; Region: PRC; pfam05239 693977001826 PRC-barrel domain; Region: PRC; pfam05239 693977001827 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 693977001828 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 693977001829 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 693977001830 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693977001831 Walker A/P-loop; other site 693977001832 ATP binding site [chemical binding]; other site 693977001833 Q-loop/lid; other site 693977001834 ABC transporter signature motif; other site 693977001835 Walker B; other site 693977001836 D-loop; other site 693977001837 H-loop/switch region; other site 693977001838 Protein of unknown function (DUF970); Region: DUF970; cl17525 693977001839 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 693977001840 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 693977001841 putative active site [active] 693977001842 Zn binding site [ion binding]; other site 693977001843 2-phosphoglycerate kinase; Provisional; Region: PRK12337 693977001844 AAA domain; Region: AAA_17; pfam13207 693977001845 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693977001846 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693977001847 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693977001848 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693977001849 NlpC/P60 family; Region: NLPC_P60; pfam00877 693977001850 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 693977001851 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 693977001852 hinge; other site 693977001853 active site 693977001854 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 693977001855 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 693977001856 hexamer interface [polypeptide binding]; other site 693977001857 ligand binding site [chemical binding]; other site 693977001858 putative active site [active] 693977001859 NAD(P) binding site [chemical binding]; other site 693977001860 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 693977001861 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693977001862 putative DNA binding site [nucleotide binding]; other site 693977001863 putative Zn2+ binding site [ion binding]; other site 693977001864 AsnC family; Region: AsnC_trans_reg; pfam01037 693977001865 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 693977001866 active site 693977001867 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 693977001868 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 693977001869 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693977001870 Walker A motif; other site 693977001871 ATP binding site [chemical binding]; other site 693977001872 Walker B motif; other site 693977001873 arginine finger; other site 693977001874 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693977001875 Walker A motif; other site 693977001876 ATP binding site [chemical binding]; other site 693977001877 Walker B motif; other site 693977001878 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 693977001879 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693977001880 Coenzyme A binding pocket [chemical binding]; other site 693977001881 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 693977001882 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 693977001883 active site 693977001884 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693977001885 dimer interface [polypeptide binding]; other site 693977001886 substrate binding site [chemical binding]; other site 693977001887 catalytic residues [active] 693977001888 prolyl-tRNA synthetase; Provisional; Region: PRK08661 693977001889 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 693977001890 dimer interface [polypeptide binding]; other site 693977001891 motif 1; other site 693977001892 active site 693977001893 motif 2; other site 693977001894 motif 3; other site 693977001895 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 693977001896 anticodon binding site; other site 693977001897 zinc-binding site [ion binding]; other site 693977001898 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 693977001899 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693977001900 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 693977001901 Sm and related proteins; Region: Sm_like; cl00259 693977001902 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 693977001903 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 693977001904 putative oligomer interface [polypeptide binding]; other site 693977001905 putative RNA binding site [nucleotide binding]; other site 693977001906 transcription termination factor NusA; Region: NusA; TIGR01953 693977001907 NusA N-terminal domain; Region: NusA_N; pfam08529 693977001908 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 693977001909 RNA binding site [nucleotide binding]; other site 693977001910 homodimer interface [polypeptide binding]; other site 693977001911 NusA-like KH domain; Region: KH_5; pfam13184 693977001912 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 693977001913 G-X-X-G motif; other site 693977001914 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 693977001915 putative RNA binding cleft [nucleotide binding]; other site 693977001916 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 693977001917 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 693977001918 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 693977001919 G1 box; other site 693977001920 putative GEF interaction site [polypeptide binding]; other site 693977001921 GTP/Mg2+ binding site [chemical binding]; other site 693977001922 Switch I region; other site 693977001923 G2 box; other site 693977001924 G3 box; other site 693977001925 Switch II region; other site 693977001926 G4 box; other site 693977001927 G5 box; other site 693977001928 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 693977001929 Translation-initiation factor 2; Region: IF-2; pfam11987 693977001930 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 693977001931 GTP-binding protein YchF; Reviewed; Region: PRK09601 693977001932 YchF GTPase; Region: YchF; cd01900 693977001933 G1 box; other site 693977001934 GTP/Mg2+ binding site [chemical binding]; other site 693977001935 Switch I region; other site 693977001936 G2 box; other site 693977001937 Switch II region; other site 693977001938 G3 box; other site 693977001939 G4 box; other site 693977001940 G5 box; other site 693977001941 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 693977001942 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 693977001943 Ferritin-like domain; Region: Ferritin; pfam00210 693977001944 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 693977001945 dimerization interface [polypeptide binding]; other site 693977001946 DPS ferroxidase diiron center [ion binding]; other site 693977001947 ion pore; other site 693977001948 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 693977001949 dimer interface [polypeptide binding]; other site 693977001950 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693977001951 metal binding site [ion binding]; metal-binding site 693977001952 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 693977001953 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 693977001954 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 693977001955 active site 693977001956 Zn binding site [ion binding]; other site 693977001957 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 693977001958 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693977001959 Zn2+ binding site [ion binding]; other site 693977001960 Mg2+ binding site [ion binding]; other site 693977001961 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 693977001962 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 693977001963 intersubunit interface [polypeptide binding]; other site 693977001964 Cytochrome c; Region: Cytochrom_C; pfam00034 693977001965 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 693977001966 tetramerization interface [polypeptide binding]; other site 693977001967 active site 693977001968 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 693977001969 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693977001970 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693977001971 metal binding site [ion binding]; metal-binding site 693977001972 active site 693977001973 I-site; other site 693977001974 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 693977001975 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 693977001976 motif 1; other site 693977001977 active site 693977001978 motif 2; other site 693977001979 motif 3; other site 693977001980 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 693977001981 Tetratricopeptide repeat; Region: TPR_12; pfam13424 693977001982 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 693977001983 TPR motif; other site 693977001984 binding surface 693977001985 Tetratricopeptide repeat; Region: TPR_12; pfam13424 693977001986 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693977001987 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693977001988 metal binding site [ion binding]; metal-binding site 693977001989 active site 693977001990 I-site; other site 693977001991 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693977001992 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 693977001993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693977001994 active site 693977001995 phosphorylation site [posttranslational modification] 693977001996 intermolecular recognition site; other site 693977001997 dimerization interface [polypeptide binding]; other site 693977001998 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 693977001999 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 693977002000 active site 693977002001 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 693977002002 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 693977002003 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 693977002004 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 693977002005 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 693977002006 active site 693977002007 benzoate transport; Region: 2A0115; TIGR00895 693977002008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693977002009 putative substrate translocation pore; other site 693977002010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693977002011 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 693977002012 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 693977002013 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 693977002014 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 693977002015 active site 693977002016 dimer interface [polypeptide binding]; other site 693977002017 motif 1; other site 693977002018 motif 2; other site 693977002019 motif 3; other site 693977002020 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 693977002021 anticodon binding site; other site 693977002022 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 693977002023 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 693977002024 potential catalytic triad [active] 693977002025 conserved cys residue [active] 693977002026 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 693977002027 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 693977002028 DNA binding residues [nucleotide binding] 693977002029 putative dimer interface [polypeptide binding]; other site 693977002030 signal recognition particle protein; Provisional; Region: PRK10867 693977002031 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 693977002032 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 693977002033 P loop; other site 693977002034 GTP binding site [chemical binding]; other site 693977002035 Signal peptide binding domain; Region: SRP_SPB; pfam02978 693977002036 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 693977002037 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693977002038 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 693977002039 Dehydroquinase class II; Region: DHquinase_II; pfam01220 693977002040 trimer interface [polypeptide binding]; other site 693977002041 active site 693977002042 dimer interface [polypeptide binding]; other site 693977002043 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 693977002044 active site 693977002045 dimer interface [polypeptide binding]; other site 693977002046 metal binding site [ion binding]; metal-binding site 693977002047 shikimate kinase; Provisional; Region: PRK13948 693977002048 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 693977002049 ADP binding site [chemical binding]; other site 693977002050 magnesium binding site [ion binding]; other site 693977002051 putative shikimate binding site; other site 693977002052 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 693977002053 active site 693977002054 catalytic triad [active] 693977002055 Uncharacterized conserved protein [Function unknown]; Region: COG4850 693977002056 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 693977002057 ribonuclease R; Region: RNase_R; TIGR02063 693977002058 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 693977002059 RNB domain; Region: RNB; pfam00773 693977002060 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 693977002061 RNA binding site [nucleotide binding]; other site 693977002062 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 693977002063 putative catalytic site [active] 693977002064 putative metal binding site [ion binding]; other site 693977002065 putative phosphate binding site [ion binding]; other site 693977002066 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 693977002067 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 693977002068 active site 693977002069 ATP binding site [chemical binding]; other site 693977002070 substrate binding site [chemical binding]; other site 693977002071 activation loop (A-loop); other site 693977002072 Predicted membrane protein [Function unknown]; Region: COG2364 693977002073 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 693977002074 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 693977002075 putative NAD(P) binding site [chemical binding]; other site 693977002076 putative active site [active] 693977002077 Predicted secreted protein (DUF2259); Region: DUF2259; cl02309 693977002078 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 693977002079 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 693977002080 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 693977002081 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 693977002082 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 693977002083 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 693977002084 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 693977002085 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 693977002086 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 693977002087 DNA binding site [nucleotide binding] 693977002088 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 693977002089 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 693977002090 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 693977002091 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 693977002092 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 693977002093 RPB12 interaction site [polypeptide binding]; other site 693977002094 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 693977002095 RPB10 interaction site [polypeptide binding]; other site 693977002096 RPB1 interaction site [polypeptide binding]; other site 693977002097 RPB11 interaction site [polypeptide binding]; other site 693977002098 RPB3 interaction site [polypeptide binding]; other site 693977002099 RPB12 interaction site [polypeptide binding]; other site 693977002100 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 693977002101 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 693977002102 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693977002103 inhibitor-cofactor binding pocket; inhibition site 693977002104 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693977002105 catalytic residue [active] 693977002106 Protein of unknown function (DUF1517); Region: DUF1517; cl01807 693977002107 PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393 693977002108 active site 693977002109 GAF domain; Region: GAF_3; pfam13492 693977002110 GAF domain; Region: GAF_2; pfam13185 693977002111 PAS domain; Region: PAS; smart00091 693977002112 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 693977002113 Histidine kinase; Region: HisKA_3; pfam07730 693977002114 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693977002115 ATP binding site [chemical binding]; other site 693977002116 Mg2+ binding site [ion binding]; other site 693977002117 G-X-G motif; other site 693977002118 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693977002119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693977002120 active site 693977002121 phosphorylation site [posttranslational modification] 693977002122 intermolecular recognition site; other site 693977002123 dimerization interface [polypeptide binding]; other site 693977002124 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693977002125 DNA binding residues [nucleotide binding] 693977002126 dimerization interface [polypeptide binding]; other site 693977002127 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693977002128 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693977002129 metal binding site [ion binding]; metal-binding site 693977002130 active site 693977002131 I-site; other site 693977002132 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693977002133 Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl17317 693977002134 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 693977002135 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 693977002136 active site 693977002137 DNA binding site [nucleotide binding] 693977002138 Int/Topo IB signature motif; other site 693977002139 catalytic residues [active] 693977002140 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693977002141 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 693977002142 Peptidase family M23; Region: Peptidase_M23; pfam01551 693977002143 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 693977002144 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 693977002145 generic binding surface II; other site 693977002146 ssDNA binding site; other site 693977002147 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693977002148 ATP binding site [chemical binding]; other site 693977002149 putative Mg++ binding site [ion binding]; other site 693977002150 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693977002151 nucleotide binding region [chemical binding]; other site 693977002152 ATP-binding site [chemical binding]; other site 693977002153 Protein of unknown function (DUF2572); Region: DUF2572; pfam10833 693977002154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693977002155 short chain dehydrogenase; Provisional; Region: PRK07454 693977002156 NAD(P) binding site [chemical binding]; other site 693977002157 active site 693977002158 Uncharacterized conserved protein [Function unknown]; Region: COG1434 693977002159 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 693977002160 putative active site [active] 693977002161 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 693977002162 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14323 693977002163 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 693977002164 active site 693977002165 substrate binding site [chemical binding]; other site 693977002166 metal binding site [ion binding]; metal-binding site 693977002167 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 693977002168 active site 693977002169 DNA binding site [nucleotide binding] 693977002170 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 693977002171 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693977002172 catalytic loop [active] 693977002173 iron binding site [ion binding]; other site 693977002174 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 693977002175 OsmC-like protein; Region: OsmC; cl00767 693977002176 CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918 693977002177 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 693977002178 ligand binding site [chemical binding]; other site 693977002179 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 693977002180 non-specific DNA interactions [nucleotide binding]; other site 693977002181 DNA binding site [nucleotide binding] 693977002182 sequence specific DNA binding site [nucleotide binding]; other site 693977002183 putative cAMP binding site [chemical binding]; other site 693977002184 DNA gyrase subunit A; Validated; Region: PRK05560 693977002185 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 693977002186 CAP-like domain; other site 693977002187 active site 693977002188 primary dimer interface [polypeptide binding]; other site 693977002189 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693977002190 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693977002191 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693977002192 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693977002193 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693977002194 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693977002195 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 693977002196 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 693977002197 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 693977002198 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693977002199 P-loop; other site 693977002200 Magnesium ion binding site [ion binding]; other site 693977002201 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 693977002202 active site 693977002203 HIGH motif; other site 693977002204 nucleotide binding site [chemical binding]; other site 693977002205 active site 693977002206 KMSKS motif; other site 693977002207 Pantoate-beta-alanine ligase; Region: PanC; cd00560 693977002208 pantoate--beta-alanine ligase; Region: panC; TIGR00018 693977002209 active site 693977002210 ATP-binding site [chemical binding]; other site 693977002211 pantoate-binding site; other site 693977002212 HXXH motif; other site 693977002213 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 693977002214 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693977002215 Walker A motif; other site 693977002216 ATP binding site [chemical binding]; other site 693977002217 Walker B motif; other site 693977002218 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 693977002219 transcription elongation factor GreA; Region: greA; TIGR01462 693977002220 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 693977002221 4-alpha-glucanotransferase; Provisional; Region: PRK14508 693977002222 Phospholipid methyltransferase; Region: PEMT; cl17370 693977002223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693977002224 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693977002225 putative substrate translocation pore; other site 693977002226 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 693977002227 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 693977002228 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 693977002229 active site 693977002230 dimer interface [polypeptide binding]; other site 693977002231 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 693977002232 dimer interface [polypeptide binding]; other site 693977002233 active site 693977002234 Protein of unknown function (DUF4127); Region: DUF4127; pfam13552 693977002235 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 693977002236 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 693977002237 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693977002238 motif II; other site 693977002239 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 693977002240 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693977002241 ATP binding site [chemical binding]; other site 693977002242 putative Mg++ binding site [ion binding]; other site 693977002243 nucleotide binding region [chemical binding]; other site 693977002244 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 693977002245 ATP-binding site [chemical binding]; other site 693977002246 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 693977002247 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 693977002248 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 693977002249 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 693977002250 EamA-like transporter family; Region: EamA; pfam00892 693977002251 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 693977002252 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 693977002253 Catalytic site [active] 693977002254 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 693977002255 Protein of unknown function (DUF503); Region: DUF503; cl00669 693977002256 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 693977002257 Protein of unknown function (DUF1999); Region: DUF1999; pfam09390 693977002258 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 693977002259 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 693977002260 acyl-activating enzyme (AAE) consensus motif; other site 693977002261 putative AMP binding site [chemical binding]; other site 693977002262 putative active site [active] 693977002263 putative CoA binding site [chemical binding]; other site 693977002264 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 693977002265 Transglycosylase; Region: Transgly; pfam00912 693977002266 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 693977002267 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 693977002268 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 693977002269 CoA-binding site [chemical binding]; other site 693977002270 ATP-binding [chemical binding]; other site 693977002271 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 693977002272 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 693977002273 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 693977002274 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 693977002275 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 693977002276 ferredoxin-NADP+ reductase; Region: PLN02852 693977002277 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693977002278 Phytase; Region: Phytase; cl17685 693977002279 short chain dehydrogenase; Provisional; Region: PRK07326 693977002280 classical (c) SDR, subgroup 4; Region: SDR_c4; cd08929 693977002281 putative NAD(P) binding site [chemical binding]; other site 693977002282 homodimer interface [polypeptide binding]; other site 693977002283 active site 693977002284 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333 693977002285 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 693977002286 homodimer interface [polypeptide binding]; other site 693977002287 metal binding site [ion binding]; metal-binding site 693977002288 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 693977002289 putative active site [active] 693977002290 putative CoA binding site [chemical binding]; other site 693977002291 nudix motif; other site 693977002292 metal binding site [ion binding]; metal-binding site 693977002293 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 693977002294 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 693977002295 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 693977002296 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693977002297 ATP binding site [chemical binding]; other site 693977002298 putative Mg++ binding site [ion binding]; other site 693977002299 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 693977002300 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693977002301 nucleotide binding region [chemical binding]; other site 693977002302 ATP-binding site [chemical binding]; other site 693977002303 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 693977002304 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 693977002305 G1 box; other site 693977002306 putative GEF interaction site [polypeptide binding]; other site 693977002307 GTP/Mg2+ binding site [chemical binding]; other site 693977002308 Switch I region; other site 693977002309 G2 box; other site 693977002310 G3 box; other site 693977002311 Switch II region; other site 693977002312 G4 box; other site 693977002313 G5 box; other site 693977002314 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 693977002315 Uncharacterized conserved protein [Function unknown]; Region: COG3603 693977002316 Family description; Region: ACT_7; pfam13840 693977002317 short chain dehydrogenase; Provisional; Region: PRK08219 693977002318 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693977002319 NAD(P) binding site [chemical binding]; other site 693977002320 active site 693977002321 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 693977002322 putative homodimer interface [polypeptide binding]; other site 693977002323 putative active site pocket [active] 693977002324 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 693977002325 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693977002326 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693977002327 dimer interface [polypeptide binding]; other site 693977002328 phosphorylation site [posttranslational modification] 693977002329 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693977002330 ATP binding site [chemical binding]; other site 693977002331 Mg2+ binding site [ion binding]; other site 693977002332 G-X-G motif; other site 693977002333 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 693977002334 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 693977002335 active site 693977002336 Ap6A binding site [chemical binding]; other site 693977002337 nudix motif; other site 693977002338 metal binding site [ion binding]; metal-binding site 693977002339 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 693977002340 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 693977002341 trimer interface [polypeptide binding]; other site 693977002342 putative metal binding site [ion binding]; other site 693977002343 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693977002344 DNA-binding site [nucleotide binding]; DNA binding site 693977002345 RNA-binding motif; other site 693977002346 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 693977002347 Glucose inhibited division protein A; Region: GIDA; pfam01134 693977002348 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693977002349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693977002350 ATP binding site [chemical binding]; other site 693977002351 Mg2+ binding site [ion binding]; other site 693977002352 G-X-G motif; other site 693977002353 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693977002354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693977002355 active site 693977002356 phosphorylation site [posttranslational modification] 693977002357 intermolecular recognition site; other site 693977002358 dimerization interface [polypeptide binding]; other site 693977002359 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693977002360 DNA binding residues [nucleotide binding] 693977002361 dimerization interface [polypeptide binding]; other site 693977002362 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 693977002363 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 693977002364 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 693977002365 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693977002366 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14603 693977002367 RuvA N terminal domain; Region: RuvA_N; pfam01330 693977002368 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 693977002369 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 693977002370 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 693977002371 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 693977002372 nucleotide binding pocket [chemical binding]; other site 693977002373 K-X-D-G motif; other site 693977002374 catalytic site [active] 693977002375 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 693977002376 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 693977002377 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 693977002378 Dimer interface [polypeptide binding]; other site 693977002379 BRCT sequence motif; other site 693977002380 Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700 693977002381 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 693977002382 peripheral dimer interface [polypeptide binding]; other site 693977002383 core dimer interface [polypeptide binding]; other site 693977002384 L10 interface [polypeptide binding]; other site 693977002385 L11 interface [polypeptide binding]; other site 693977002386 putative EF-Tu interaction site [polypeptide binding]; other site 693977002387 putative EF-G interaction site [polypeptide binding]; other site 693977002388 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 693977002389 23S rRNA interface [nucleotide binding]; other site 693977002390 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 693977002391 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 693977002392 mRNA/rRNA interface [nucleotide binding]; other site 693977002393 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 693977002394 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 693977002395 23S rRNA interface [nucleotide binding]; other site 693977002396 L7/L12 interface [polypeptide binding]; other site 693977002397 putative thiostrepton binding site; other site 693977002398 L25 interface [polypeptide binding]; other site 693977002399 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 693977002400 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 693977002401 putative homodimer interface [polypeptide binding]; other site 693977002402 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 693977002403 heterodimer interface [polypeptide binding]; other site 693977002404 homodimer interface [polypeptide binding]; other site 693977002405 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 693977002406 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 693977002407 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 693977002408 Part of AAA domain; Region: AAA_19; pfam13245 693977002409 Family description; Region: UvrD_C_2; pfam13538 693977002410 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 693977002411 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 693977002412 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 693977002413 phosphate binding site [ion binding]; other site 693977002414 putative substrate binding pocket [chemical binding]; other site 693977002415 dimer interface [polypeptide binding]; other site 693977002416 S-layer homology domain; Region: SLH; pfam00395 693977002417 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 693977002418 iron-sulfur cluster [ion binding]; other site 693977002419 [2Fe-2S] cluster binding site [ion binding]; other site 693977002420 TPR repeat; Region: TPR_11; pfam13414 693977002421 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693977002422 TPR motif; other site 693977002423 binding surface 693977002424 Tetratricopeptide repeat; Region: TPR_9; pfam13371 693977002425 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 693977002426 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 693977002427 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 693977002428 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 693977002429 catalytic residues [active] 693977002430 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 693977002431 CcmE; Region: CcmE; pfam03100 693977002432 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 693977002433 Rhomboid family; Region: Rhomboid; pfam01694 693977002434 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 693977002435 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 693977002436 glycogen branching enzyme; Provisional; Region: PRK14706 693977002437 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 693977002438 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 693977002439 active site 693977002440 catalytic site [active] 693977002441 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 693977002442 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693977002443 active site 693977002444 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 693977002445 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 693977002446 Mg++ binding site [ion binding]; other site 693977002447 putative catalytic motif [active] 693977002448 substrate binding site [chemical binding]; other site 693977002449 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 693977002450 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 693977002451 active site 693977002452 homodimer interface [polypeptide binding]; other site 693977002453 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 693977002454 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 693977002455 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 693977002456 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 693977002457 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693977002458 motif II; other site 693977002459 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 693977002460 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 693977002461 HIGH motif; other site 693977002462 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 693977002463 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 693977002464 active site 693977002465 KMSKS motif; other site 693977002466 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 693977002467 tRNA binding surface [nucleotide binding]; other site 693977002468 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 693977002469 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 693977002470 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 693977002471 MraW methylase family; Region: Methyltransf_5; cl17771 693977002472 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 693977002473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 693977002474 MraZ protein; Region: MraZ; pfam02381 693977002475 MraZ protein; Region: MraZ; pfam02381 693977002476 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693977002477 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693977002478 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 693977002479 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693977002480 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693977002481 homodimer interface [polypeptide binding]; other site 693977002482 catalytic residue [active] 693977002483 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 693977002484 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 693977002485 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 693977002486 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 693977002487 active site 693977002488 FemAB family; Region: FemAB; pfam02388 693977002489 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 693977002490 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 693977002491 active site 693977002492 catalytic residues [active] 693977002493 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 693977002494 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 693977002495 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14334 693977002496 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 693977002497 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693977002498 FeS/SAM binding site; other site 693977002499 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 693977002500 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 693977002501 active site 693977002502 substrate-binding site [chemical binding]; other site 693977002503 metal-binding site [ion binding] 693977002504 ATP binding site [chemical binding]; other site 693977002505 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 693977002506 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 693977002507 Walker A/P-loop; other site 693977002508 ATP binding site [chemical binding]; other site 693977002509 Q-loop/lid; other site 693977002510 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 693977002511 ABC transporter signature motif; other site 693977002512 Walker B; other site 693977002513 D-loop; other site 693977002514 H-loop/switch region; other site 693977002515 PrcB C-terminal; Region: PrcB_C; pfam14343 693977002516 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 693977002517 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693977002518 active site 693977002519 motif I; other site 693977002520 motif II; other site 693977002521 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693977002522 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 693977002523 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 693977002524 putative dimer interface [polypeptide binding]; other site 693977002525 putative anticodon binding site; other site 693977002526 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 693977002527 homodimer interface [polypeptide binding]; other site 693977002528 motif 1; other site 693977002529 motif 2; other site 693977002530 active site 693977002531 motif 3; other site 693977002532 triosephosphate isomerase; Provisional; Region: PRK14567 693977002533 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 693977002534 substrate binding site [chemical binding]; other site 693977002535 dimer interface [polypeptide binding]; other site 693977002536 catalytic triad [active] 693977002537 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 693977002538 Phosphoglycerate kinase; Region: PGK; pfam00162 693977002539 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 693977002540 substrate binding site [chemical binding]; other site 693977002541 hinge regions; other site 693977002542 ADP binding site [chemical binding]; other site 693977002543 catalytic site [active] 693977002544 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 693977002545 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 693977002546 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 693977002547 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 693977002548 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 693977002549 CopC domain; Region: CopC; cl01012 693977002550 aspartate kinase; Provisional; Region: PRK06291 693977002551 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 693977002552 nucleotide binding site [chemical binding]; other site 693977002553 substrate binding site [chemical binding]; other site 693977002554 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 693977002555 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 693977002556 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 693977002557 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 693977002558 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 693977002559 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 693977002560 catalytic residues [active] 693977002561 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 693977002562 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 693977002563 active site turn [active] 693977002564 phosphorylation site [posttranslational modification] 693977002565 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 693977002566 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 693977002567 HPr interaction site; other site 693977002568 glycerol kinase (GK) interaction site [polypeptide binding]; other site 693977002569 active site 693977002570 phosphorylation site [posttranslational modification] 693977002571 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 693977002572 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 693977002573 putative substrate binding site [chemical binding]; other site 693977002574 putative ATP binding site [chemical binding]; other site 693977002575 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 693977002576 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 693977002577 substrate binding [chemical binding]; other site 693977002578 active site 693977002579 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 693977002580 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 693977002581 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 693977002582 active site 693977002583 HIGH motif; other site 693977002584 nucleotide binding site [chemical binding]; other site 693977002585 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 693977002586 active site 693977002587 KMSKS motif; other site 693977002588 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 693977002589 tRNA binding surface [nucleotide binding]; other site 693977002590 anticodon binding site; other site 693977002591 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 693977002592 active site 693977002593 intersubunit interactions; other site 693977002594 catalytic residue [active] 693977002595 transcription termination factor Rho; Provisional; Region: rho; PRK09376 693977002596 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 693977002597 RNA binding site [nucleotide binding]; other site 693977002598 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693977002599 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693977002600 Walker A motif; other site 693977002601 Walker A motif; other site 693977002602 ATP binding site [chemical binding]; other site 693977002603 Walker B motif; other site 693977002604 PGAP1-like protein; Region: PGAP1; pfam07819 693977002605 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693977002606 TAP-like protein; Region: Abhydrolase_4; pfam08386 693977002607 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 693977002608 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 693977002609 active site 693977002610 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 693977002611 NlpC/P60 family; Region: NLPC_P60; pfam00877 693977002612 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 693977002613 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 693977002614 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 693977002615 putative active site [active] 693977002616 catalytic triad [active] 693977002617 putative dimer interface [polypeptide binding]; other site 693977002618 H+ Antiporter protein; Region: 2A0121; TIGR00900 693977002619 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 693977002620 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 693977002621 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 693977002622 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 693977002623 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 693977002624 dimer interface [polypeptide binding]; other site 693977002625 motif 1; other site 693977002626 active site 693977002627 motif 2; other site 693977002628 motif 3; other site 693977002629 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 693977002630 anticodon binding site; other site 693977002631 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 693977002632 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 693977002633 dimer interface [polypeptide binding]; other site 693977002634 anticodon binding site; other site 693977002635 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 693977002636 homodimer interface [polypeptide binding]; other site 693977002637 motif 1; other site 693977002638 active site 693977002639 motif 2; other site 693977002640 GAD domain; Region: GAD; pfam02938 693977002641 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 693977002642 active site 693977002643 motif 3; other site 693977002644 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 693977002645 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 693977002646 GIY-YIG motif/motif A; other site 693977002647 active site 693977002648 catalytic site [active] 693977002649 putative DNA binding site [nucleotide binding]; other site 693977002650 metal binding site [ion binding]; metal-binding site 693977002651 UvrB/uvrC motif; Region: UVR; pfam02151 693977002652 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 693977002653 EDD domain protein, DegV family; Region: DegV; TIGR00762 693977002654 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 693977002655 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 693977002656 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 693977002657 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 693977002658 CoA binding domain; Region: CoA_binding; pfam02629 693977002659 CoA-ligase; Region: Ligase_CoA; pfam00549 693977002660 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 693977002661 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 693977002662 CoA-ligase; Region: Ligase_CoA; pfam00549 693977002663 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 693977002664 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 693977002665 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 693977002666 active site 693977002667 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 693977002668 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 693977002669 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 693977002670 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 693977002671 Protein of unknown function (DUF1622); Region: DUF1622; cl01991 693977002672 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 693977002673 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 693977002674 EDD domain protein, DegV family; Region: DegV; TIGR00762 693977002675 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 693977002676 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 693977002677 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 693977002678 Asp_Lys_Asn_RS_N: N-terminal, anticodon recognition domain of class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. Class 2b aaRSs include the homodimeric aspartyl-; Region: Asp_Lys_Asn_RS_N; cd04100 693977002679 Dimer interface [polypeptide binding]; other site 693977002680 anticodon binding site; other site 693977002681 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 693977002682 homodimer interface [polypeptide binding]; other site 693977002683 motif 1; other site 693977002684 motif 2; other site 693977002685 active site 693977002686 motif 3; other site 693977002687 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 693977002688 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 693977002689 active site 693977002690 recombination protein F; Provisional; Region: recF; PRK14079 693977002691 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693977002692 Walker A/P-loop; other site 693977002693 ATP binding site [chemical binding]; other site 693977002694 Q-loop/lid; other site 693977002695 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693977002696 ABC transporter signature motif; other site 693977002697 Walker B; other site 693977002698 D-loop; other site 693977002699 H-loop/switch region; other site 693977002700 Protein of unknown function (DUF721); Region: DUF721; pfam05258 693977002701 Protein of unknown function (DUF721); Region: DUF721; cl02324 693977002702 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 693977002703 MPT binding site; other site 693977002704 trimer interface [polypeptide binding]; other site 693977002705 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 693977002706 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 693977002707 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 693977002708 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693977002709 Walker A/P-loop; other site 693977002710 ATP binding site [chemical binding]; other site 693977002711 Q-loop/lid; other site 693977002712 ABC transporter signature motif; other site 693977002713 Walker B; other site 693977002714 D-loop; other site 693977002715 H-loop/switch region; other site 693977002716 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 693977002717 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 693977002718 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 693977002719 PhoH-like protein; Region: PhoH; pfam02562 693977002720 superoxide dismutase; Provisional; Region: PRK10925 693977002721 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 693977002722 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 693977002723 Protein of unknown function (DUF3208); Region: DUF3208; pfam11482 693977002724 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 693977002725 dimer interface [polypeptide binding]; other site 693977002726 active site 693977002727 Schiff base residues; other site 693977002728 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 693977002729 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 693977002730 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 693977002731 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693977002732 catalytic loop [active] 693977002733 iron binding site [ion binding]; other site 693977002734 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 693977002735 L-aspartate oxidase; Provisional; Region: PRK06175 693977002736 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 693977002737 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 693977002738 putative Iron-sulfur protein interface [polypeptide binding]; other site 693977002739 putative proximal heme binding site [chemical binding]; other site 693977002740 putative SdhC-like subunit interface [polypeptide binding]; other site 693977002741 putative distal heme binding site [chemical binding]; other site 693977002742 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 693977002743 putative Iron-sulfur protein interface [polypeptide binding]; other site 693977002744 putative proximal heme binding site [chemical binding]; other site 693977002745 putative SdhD-like interface [polypeptide binding]; other site 693977002746 putative distal heme binding site [chemical binding]; other site 693977002747 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 693977002748 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 693977002749 Ligand Binding Site [chemical binding]; other site 693977002750 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693977002751 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693977002752 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 693977002753 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 693977002754 NADP binding site [chemical binding]; other site 693977002755 dimer interface [polypeptide binding]; other site 693977002756 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 693977002757 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 693977002758 RNA binding site [nucleotide binding]; other site 693977002759 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 693977002760 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 693977002761 hinge; other site 693977002762 active site 693977002763 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 693977002764 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693977002765 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 693977002766 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 693977002767 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693977002768 catalytic residue [active] 693977002769 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 693977002770 hypothetical protein; Provisional; Region: PRK04233 693977002771 SEC-C motif; Region: SEC-C; pfam02810 693977002772 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 693977002773 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 693977002774 HIGH motif; other site 693977002775 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 693977002776 active site 693977002777 KMSKS motif; other site 693977002778 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 693977002779 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 693977002780 substrate binding pocket [chemical binding]; other site 693977002781 chain length determination region; other site 693977002782 substrate-Mg2+ binding site; other site 693977002783 catalytic residues [active] 693977002784 aspartate-rich region 1; other site 693977002785 active site lid residues [active] 693977002786 aspartate-rich region 2; other site 693977002787 Peptidase family M23; Region: Peptidase_M23; pfam01551 693977002788 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 693977002789 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 693977002790 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 693977002791 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693977002792 Walker A/P-loop; other site 693977002793 ATP binding site [chemical binding]; other site 693977002794 Q-loop/lid; other site 693977002795 ABC transporter signature motif; other site 693977002796 Walker B; other site 693977002797 D-loop; other site 693977002798 H-loop/switch region; other site 693977002799 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 693977002800 C-terminal peptidase (prc); Region: prc; TIGR00225 693977002801 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 693977002802 protein binding site [polypeptide binding]; other site 693977002803 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 693977002804 Catalytic dyad [active] 693977002805 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 693977002806 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 693977002807 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 693977002808 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 693977002809 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 693977002810 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 693977002811 nudix motif; other site 693977002812 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 693977002813 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 693977002814 active site 693977002815 HIGH motif; other site 693977002816 nucleotide binding site [chemical binding]; other site 693977002817 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 693977002818 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 693977002819 active site 693977002820 KMSKS motif; other site 693977002821 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 693977002822 tRNA binding surface [nucleotide binding]; other site 693977002823 anticodon binding site; other site 693977002824 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 693977002825 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 693977002826 SdpI/YhfL protein family; Region: SdpI; pfam13630 693977002827 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693977002828 dimerization interface [polypeptide binding]; other site 693977002829 putative DNA binding site [nucleotide binding]; other site 693977002830 putative Zn2+ binding site [ion binding]; other site 693977002831 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 693977002832 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 693977002833 AAA domain; Region: AAA_33; pfam13671 693977002834 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 693977002835 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 693977002836 TilS substrate C-terminal domain; Region: TilS_C; smart00977 693977002837 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 693977002838 nucleoside/Zn binding site; other site 693977002839 dimer interface [polypeptide binding]; other site 693977002840 catalytic motif [active] 693977002841 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 693977002842 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693977002843 putative DNA binding site [nucleotide binding]; other site 693977002844 putative Zn2+ binding site [ion binding]; other site 693977002845 AsnC family; Region: AsnC_trans_reg; pfam01037 693977002846 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 693977002847 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 693977002848 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 693977002849 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 693977002850 active site 693977002851 metal binding site [ion binding]; metal-binding site 693977002852 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 693977002853 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693977002854 PAS fold; Region: PAS_3; pfam08447 693977002855 putative active site [active] 693977002856 heme pocket [chemical binding]; other site 693977002857 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 693977002858 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693977002859 Zn2+ binding site [ion binding]; other site 693977002860 Mg2+ binding site [ion binding]; other site 693977002861 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK14811 693977002862 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 693977002863 DNA binding site [nucleotide binding] 693977002864 catalytic residue [active] 693977002865 H2TH interface [polypeptide binding]; other site 693977002866 putative catalytic residues [active] 693977002867 turnover-facilitating residue; other site 693977002868 intercalation triad [nucleotide binding]; other site 693977002869 8OG recognition residue [nucleotide binding]; other site 693977002870 putative reading head residues; other site 693977002871 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 693977002872 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 693977002873 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 693977002874 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 693977002875 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 693977002876 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 693977002877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 693977002878 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 693977002879 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 693977002880 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 693977002881 active site 693977002882 non-prolyl cis peptide bond; other site 693977002883 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693977002884 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693977002885 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 693977002886 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 693977002887 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 693977002888 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 693977002889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693977002890 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 693977002891 putative substrate translocation pore; other site 693977002892 DNA polymerase I; Region: pola; TIGR00593 693977002893 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 693977002894 active site 693977002895 metal binding site 1 [ion binding]; metal-binding site 693977002896 putative 5' ssDNA interaction site; other site 693977002897 metal binding site 3; metal-binding site 693977002898 metal binding site 2 [ion binding]; metal-binding site 693977002899 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 693977002900 putative DNA binding site [nucleotide binding]; other site 693977002901 putative metal binding site [ion binding]; other site 693977002902 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 693977002903 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 693977002904 active site 693977002905 DNA binding site [nucleotide binding] 693977002906 catalytic site [active] 693977002907 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 693977002908 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 693977002909 Amidase; Region: Amidase; cl11426 693977002910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693977002911 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 693977002912 Walker A motif; other site 693977002913 ATP binding site [chemical binding]; other site 693977002914 Walker B motif; other site 693977002915 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 693977002916 arginine finger; other site 693977002917 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 693977002918 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 693977002919 DNA binding residues [nucleotide binding] 693977002920 dimer interface [polypeptide binding]; other site 693977002921 [2Fe-2S] cluster binding site [ion binding]; other site 693977002922 short chain dehydrogenase; Provisional; Region: PRK08309 693977002923 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 693977002924 active site 693977002925 metal binding site [ion binding]; metal-binding site 693977002926 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693977002927 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 693977002928 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 693977002929 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 693977002930 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 693977002931 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 693977002932 recombinase A; Provisional; Region: recA; PRK09354 693977002933 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 693977002934 hexamer interface [polypeptide binding]; other site 693977002935 Walker A motif; other site 693977002936 ATP binding site [chemical binding]; other site 693977002937 Walker B motif; other site 693977002938 CHASE2 domain; Region: CHASE2; pfam05226 693977002939 FecR protein; Region: FecR; pfam04773 693977002940 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 693977002941 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693977002942 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693977002943 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693977002944 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693977002945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693977002946 active site 693977002947 phosphorylation site [posttranslational modification] 693977002948 intermolecular recognition site; other site 693977002949 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693977002950 dimerization interface [polypeptide binding]; other site 693977002951 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693977002952 dimer interface [polypeptide binding]; other site 693977002953 phosphorylation site [posttranslational modification] 693977002954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693977002955 ATP binding site [chemical binding]; other site 693977002956 Mg2+ binding site [ion binding]; other site 693977002957 G-X-G motif; other site 693977002958 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693977002959 PAS domain; Region: PAS_9; pfam13426 693977002960 putative active site [active] 693977002961 heme pocket [chemical binding]; other site 693977002962 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 693977002963 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693977002964 putative active site [active] 693977002965 heme pocket [chemical binding]; other site 693977002966 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693977002967 putative active site [active] 693977002968 heme pocket [chemical binding]; other site 693977002969 GAF domain; Region: GAF_3; pfam13492 693977002970 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693977002971 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693977002972 dimer interface [polypeptide binding]; other site 693977002973 phosphorylation site [posttranslational modification] 693977002974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693977002975 ATP binding site [chemical binding]; other site 693977002976 Mg2+ binding site [ion binding]; other site 693977002977 G-X-G motif; other site 693977002978 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 693977002979 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 693977002980 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 693977002981 NAD(P) binding site [chemical binding]; other site 693977002982 shikimate binding site; other site 693977002983 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 693977002984 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 693977002985 Permutation of conserved domain; other site 693977002986 active site 693977002987 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 693977002988 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 693977002989 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 693977002990 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693977002991 RNA binding surface [nucleotide binding]; other site 693977002992 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 693977002993 active site 693977002994 TRAM domain; Region: TRAM; cl01282 693977002995 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 693977002996 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 693977002997 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 693977002998 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 693977002999 protein binding site [polypeptide binding]; other site 693977003000 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 693977003001 META domain; Region: META; pfam03724 693977003002 META domain; Region: META; pfam03724 693977003003 META domain; Region: META; cl01245 693977003004 META domain; Region: META; pfam03724 693977003005 Protein of unknown function (DUF402); Region: DUF402; cl00979 693977003006 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 693977003007 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 693977003008 active site 693977003009 substrate binding site [chemical binding]; other site 693977003010 cosubstrate binding site; other site 693977003011 catalytic site [active] 693977003012 hypothetical protein; Provisional; Region: PRK08201 693977003013 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 693977003014 metal binding site [ion binding]; metal-binding site 693977003015 putative dimer interface [polypeptide binding]; other site 693977003016 Predicted transcriptional regulators [Transcription]; Region: COG1695 693977003017 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 693977003018 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 693977003019 Uncharacterized conserved protein [Function unknown]; Region: COG1432 693977003020 LabA_like proteins; Region: LabA; cd10911 693977003021 putative metal binding site [ion binding]; other site 693977003022 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 693977003023 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 693977003024 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 693977003025 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 693977003026 dimer interface [polypeptide binding]; other site 693977003027 FMN binding site [chemical binding]; other site 693977003028 NADPH bind site [chemical binding]; other site 693977003029 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 693977003030 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 693977003031 active site 693977003032 FMN binding site [chemical binding]; other site 693977003033 substrate binding site [chemical binding]; other site 693977003034 homotetramer interface [polypeptide binding]; other site 693977003035 catalytic residue [active] 693977003036 Sulphur transport; Region: Sulf_transp; pfam04143 693977003037 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 693977003038 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 693977003039 putative RNA binding site [nucleotide binding]; other site 693977003040 S-adenosylmethionine binding site [chemical binding]; other site 693977003041 Methyltransferase domain; Region: Methyltransf_26; pfam13659 693977003042 EamA-like transporter family; Region: EamA; pfam00892 693977003043 amidase; Provisional; Region: PRK06828 693977003044 Amidase; Region: Amidase; cl11426 693977003045 DNA repair protein RadA; Provisional; Region: PRK11823 693977003046 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693977003047 Walker A motif; other site 693977003048 ATP binding site [chemical binding]; other site 693977003049 Walker B motif; other site 693977003050 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 693977003051 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 693977003052 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 693977003053 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 693977003054 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 693977003055 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 693977003056 Clp amino terminal domain; Region: Clp_N; pfam02861 693977003057 Clp amino terminal domain; Region: Clp_N; pfam02861 693977003058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693977003059 Walker A motif; other site 693977003060 ATP binding site [chemical binding]; other site 693977003061 Walker B motif; other site 693977003062 arginine finger; other site 693977003063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693977003064 Walker A motif; other site 693977003065 ATP binding site [chemical binding]; other site 693977003066 Walker B motif; other site 693977003067 arginine finger; other site 693977003068 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 693977003069 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 693977003070 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 693977003071 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 693977003072 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693977003073 inhibitor-cofactor binding pocket; inhibition site 693977003074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693977003075 catalytic residue [active] 693977003076 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 693977003077 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 693977003078 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 693977003079 putative active site [active] 693977003080 putative substrate binding site [chemical binding]; other site 693977003081 putative cosubstrate binding site; other site 693977003082 catalytic site [active] 693977003083 Uncharacterized conserved protein [Function unknown]; Region: COG0327 693977003084 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 693977003085 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 693977003086 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693977003087 ATP binding site [chemical binding]; other site 693977003088 putative Mg++ binding site [ion binding]; other site 693977003089 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693977003090 nucleotide binding region [chemical binding]; other site 693977003091 ATP-binding site [chemical binding]; other site 693977003092 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 693977003093 HRDC domain; Region: HRDC; pfam00570 693977003094 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 693977003095 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 693977003096 non-specific DNA interactions [nucleotide binding]; other site 693977003097 DNA binding site [nucleotide binding] 693977003098 sequence specific DNA binding site [nucleotide binding]; other site 693977003099 putative cAMP binding site [chemical binding]; other site 693977003100 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 693977003101 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 693977003102 amphipathic channel; other site 693977003103 Asn-Pro-Ala signature motifs; other site 693977003104 glycerol kinase; Provisional; Region: glpK; PRK00047 693977003105 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 693977003106 N- and C-terminal domain interface [polypeptide binding]; other site 693977003107 active site 693977003108 MgATP binding site [chemical binding]; other site 693977003109 catalytic site [active] 693977003110 metal binding site [ion binding]; metal-binding site 693977003111 glycerol binding site [chemical binding]; other site 693977003112 homotetramer interface [polypeptide binding]; other site 693977003113 homodimer interface [polypeptide binding]; other site 693977003114 FBP binding site [chemical binding]; other site 693977003115 protein IIAGlc interface [polypeptide binding]; other site 693977003116 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 693977003117 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693977003118 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 693977003119 B12 binding site [chemical binding]; other site 693977003120 cobalt ligand [ion binding]; other site 693977003121 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 693977003122 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 693977003123 Walker A; other site 693977003124 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 693977003125 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 693977003126 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 693977003127 dimer interface [polypeptide binding]; other site 693977003128 putative anticodon binding site; other site 693977003129 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 693977003130 motif 1; other site 693977003131 active site 693977003132 motif 2; other site 693977003133 motif 3; other site 693977003134 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 693977003135 Uncharacterized conserved protein, YhbC family [Function unknown]; Region: COG0782 693977003136 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 693977003137 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 693977003138 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 693977003139 active site 693977003140 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 693977003141 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK14655 693977003142 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 693977003143 Mg++ binding site [ion binding]; other site 693977003144 putative catalytic motif [active] 693977003145 putative substrate binding site [chemical binding]; other site 693977003146 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 693977003147 Uncharacterized conserved protein [Function unknown]; Region: COG4121 693977003148 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 693977003149 PRC-barrel domain; Region: PRC; pfam05239 693977003150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 693977003151 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 693977003152 nudix motif; other site 693977003153 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 693977003154 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 693977003155 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 693977003156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 693977003157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693977003158 putative PBP binding loops; other site 693977003159 ABC-ATPase subunit interface; other site 693977003160 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 693977003161 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693977003162 Walker A/P-loop; other site 693977003163 ATP binding site [chemical binding]; other site 693977003164 Q-loop/lid; other site 693977003165 ABC transporter signature motif; other site 693977003166 Walker B; other site 693977003167 D-loop; other site 693977003168 H-loop/switch region; other site 693977003169 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 693977003170 Thiamine pyrophosphokinase; Region: TPK; cd07995 693977003171 active site 693977003172 dimerization interface [polypeptide binding]; other site 693977003173 thiamine binding site [chemical binding]; other site 693977003174 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 693977003175 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 693977003176 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 693977003177 putative dimer interface [polypeptide binding]; other site 693977003178 catalytic triad [active] 693977003179 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 693977003180 TMAO/DMSO reductase; Reviewed; Region: PRK05363 693977003181 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 693977003182 Moco binding site; other site 693977003183 metal coordination site [ion binding]; other site 693977003184 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693977003185 MarR family; Region: MarR_2; pfam12802 693977003186 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 693977003187 Cytochrome P450; Region: p450; cl12078 693977003188 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 693977003189 beta-galactosidase; Region: BGL; TIGR03356 693977003190 peptide chain release factor 1; Validated; Region: prfA; PRK00591 693977003191 PCRF domain; Region: PCRF; pfam03462 693977003192 RF-1 domain; Region: RF-1; pfam00472 693977003193 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 693977003194 nudix motif; other site 693977003195 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 693977003196 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693977003197 RNA binding surface [nucleotide binding]; other site 693977003198 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 693977003199 active site 693977003200 hypothetical protein; Provisional; Region: PRK00766 693977003201 Protein of unknown function DUF99; Region: DUF99; pfam01949 693977003202 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 693977003203 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 693977003204 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 693977003205 hypothetical protein; Validated; Region: PRK00153 693977003206 recombination protein RecR; Reviewed; Region: recR; PRK00076 693977003207 RecR protein; Region: RecR; pfam02132 693977003208 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 693977003209 putative active site [active] 693977003210 putative metal-binding site [ion binding]; other site 693977003211 tetramer interface [polypeptide binding]; other site 693977003212 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 693977003213 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 693977003214 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693977003215 active site 693977003216 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 693977003217 catalytic core [active] 693977003218 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 693977003219 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 693977003220 dimerization interface [polypeptide binding]; other site 693977003221 putative ATP binding site [chemical binding]; other site 693977003222 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 693977003223 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 693977003224 catalytic residues [active] 693977003225 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 693977003226 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 693977003227 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 693977003228 active site 693977003229 HIGH motif; other site 693977003230 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 693977003231 KMSKS motif; other site 693977003232 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 693977003233 ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885 693977003234 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693977003235 inhibitor-cofactor binding pocket; inhibition site 693977003236 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693977003237 catalytic residue [active] 693977003238 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 693977003239 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 693977003240 DNA binding residues [nucleotide binding] 693977003241 putative dimer interface [polypeptide binding]; other site 693977003242 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 693977003243 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 693977003244 DNA binding residues [nucleotide binding] 693977003245 putative dimer interface [polypeptide binding]; other site 693977003246 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 693977003247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693977003248 S-adenosylmethionine binding site [chemical binding]; other site 693977003249 aconitate hydratase; Validated; Region: PRK09277 693977003250 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 693977003251 substrate binding site [chemical binding]; other site 693977003252 ligand binding site [chemical binding]; other site 693977003253 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 693977003254 substrate binding site [chemical binding]; other site 693977003255 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693977003256 DEAD-like helicases superfamily; Region: DEXDc; smart00487 693977003257 ATP binding site [chemical binding]; other site 693977003258 Mg++ binding site [ion binding]; other site 693977003259 motif III; other site 693977003260 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693977003261 nucleotide binding region [chemical binding]; other site 693977003262 ATP-binding site [chemical binding]; other site 693977003263 RNA-binding GUCT-like domain found in Thermus thermophilus heat resistant RNA-dependent ATPase (Hera) and similar proteins; Region: GUCT_Hera; cd12938 693977003264 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 693977003265 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 693977003266 substrate binding site [chemical binding]; other site 693977003267 ATP binding site [chemical binding]; other site 693977003268 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 693977003269 6-phosphofructokinase; Provisional; Region: PRK03202 693977003270 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 693977003271 active site 693977003272 ADP/pyrophosphate binding site [chemical binding]; other site 693977003273 dimerization interface [polypeptide binding]; other site 693977003274 allosteric effector site; other site 693977003275 fructose-1,6-bisphosphate binding site; other site 693977003276 Predicted methyltransferases [General function prediction only]; Region: COG0313 693977003277 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 693977003278 putative SAM binding site [chemical binding]; other site 693977003279 putative homodimer interface [polypeptide binding]; other site 693977003280 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 693977003281 active site 693977003282 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 693977003283 nudix motif; other site 693977003284 BON domain; Region: BON; pfam04972 693977003285 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693977003286 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 693977003287 Histidine kinase; Region: HisKA_3; pfam07730 693977003288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693977003289 ATP binding site [chemical binding]; other site 693977003290 G-X-G motif; other site 693977003291 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 693977003292 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693977003293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693977003294 active site 693977003295 phosphorylation site [posttranslational modification] 693977003296 intermolecular recognition site; other site 693977003297 dimerization interface [polypeptide binding]; other site 693977003298 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693977003299 DNA binding residues [nucleotide binding] 693977003300 dimerization interface [polypeptide binding]; other site 693977003301 periplasmic chaperone; Provisional; Region: PRK10780 693977003302 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 693977003303 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 693977003304 MutS domain III; Region: MutS_III; pfam05192 693977003305 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 693977003306 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 693977003307 Walker A/P-loop; other site 693977003308 ATP binding site [chemical binding]; other site 693977003309 Q-loop/lid; other site 693977003310 ABC transporter signature motif; other site 693977003311 Walker B; other site 693977003312 D-loop; other site 693977003313 H-loop/switch region; other site 693977003314 Smr domain; Region: Smr; pfam01713 693977003315 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 693977003316 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 693977003317 ligand binding site [chemical binding]; other site 693977003318 flexible hinge region; other site 693977003319 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 693977003320 putative switch regulator; other site 693977003321 non-specific DNA interactions [nucleotide binding]; other site 693977003322 DNA binding site [nucleotide binding] 693977003323 sequence specific DNA binding site [nucleotide binding]; other site 693977003324 putative cAMP binding site [chemical binding]; other site 693977003325 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 693977003326 Transglycosylase; Region: Transgly; pfam00912 693977003327 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 693977003328 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 693977003329 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 693977003330 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 693977003331 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 693977003332 Protein of unknown function (DUF512); Region: DUF512; pfam04459 693977003333 NAD-dependent deacetylase; Provisional; Region: PRK00481 693977003334 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 693977003335 NAD+ binding site [chemical binding]; other site 693977003336 substrate binding site [chemical binding]; other site 693977003337 Zn binding site [ion binding]; other site 693977003338 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693977003339 binding surface 693977003340 TPR motif; other site 693977003341 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 693977003342 binding surface 693977003343 TPR motif; other site 693977003344 Sporulation related domain; Region: SPOR; pfam05036 693977003345 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 693977003346 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 693977003347 CoA binding domain; Region: CoA_binding; pfam02629 693977003348 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693977003349 PEP synthetase regulatory protein; Provisional; Region: PRK05339 693977003350 phosphoenolpyruvate synthase; Validated; Region: PRK06464 693977003351 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 693977003352 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 693977003353 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 693977003354 Haemolytic domain; Region: Haemolytic; cl00506 693977003355 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 693977003356 Mechanosensitive ion channel; Region: MS_channel; pfam00924 693977003357 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 693977003358 Fasciclin domain; Region: Fasciclin; cl02663 693977003359 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 693977003360 tandem repeat interface [polypeptide binding]; other site 693977003361 oligomer interface [polypeptide binding]; other site 693977003362 active site residues [active] 693977003363 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 693977003364 tandem repeat interface [polypeptide binding]; other site 693977003365 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 693977003366 oligomer interface [polypeptide binding]; other site 693977003367 active site residues [active] 693977003368 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 693977003369 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 693977003370 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 693977003371 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 693977003372 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 693977003373 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 693977003374 putative RNA binding site [nucleotide binding]; other site 693977003375 16S rRNA methyltransferase B; Provisional; Region: PRK14902 693977003376 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 693977003377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693977003378 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693977003379 putative substrate translocation pore; other site 693977003380 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 693977003381 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 693977003382 TPP-binding site; other site 693977003383 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 693977003384 PYR/PP interface [polypeptide binding]; other site 693977003385 dimer interface [polypeptide binding]; other site 693977003386 TPP binding site [chemical binding]; other site 693977003387 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 693977003388 PspA/IM30 family; Region: PspA_IM30; pfam04012 693977003389 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 693977003390 DHH family; Region: DHH; pfam01368 693977003391 DHHA1 domain; Region: DHHA1; pfam02272 693977003392 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 693977003393 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 693977003394 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 693977003395 4Fe-4S binding domain; Region: Fer4; cl02805 693977003396 Cysteine-rich domain; Region: CCG; pfam02754 693977003397 Cysteine-rich domain; Region: CCG; pfam02754 693977003398 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 693977003399 Protein export membrane protein; Region: SecD_SecF; cl14618 693977003400 Protein export membrane protein; Region: SecD_SecF; pfam02355 693977003401 hypothetical protein; Validated; Region: PRK05629 693977003402 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 693977003403 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 693977003404 Ion channel; Region: Ion_trans_2; pfam07885 693977003405 Ion transport protein; Region: Ion_trans; pfam00520 693977003406 EamA-like transporter family; Region: EamA; pfam00892 693977003407 HerA helicase [Replication, recombination, and repair]; Region: COG0433 693977003408 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 693977003409 conserved cys residue [active] 693977003410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2380 693977003411 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 693977003412 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 693977003413 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 693977003414 Cytochrome P450; Region: p450; cl12078 693977003415 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 693977003416 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 693977003417 substrate binding site [chemical binding]; other site 693977003418 oxyanion hole (OAH) forming residues; other site 693977003419 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 693977003420 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 693977003421 active site 693977003422 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 693977003423 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 693977003424 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 693977003425 Domain of unknown function DUF20; Region: UPF0118; pfam01594 693977003426 UDP-N-acetylmuramoylalanine--D-glutamate ligase; Region: murD; TIGR01087 693977003427 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693977003428 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 693977003429 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 693977003430 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693977003431 Zn2+ binding site [ion binding]; other site 693977003432 Mg2+ binding site [ion binding]; other site 693977003433 Flagellin N-methylase; Region: FliB; cl00497 693977003434 epoxyqueuosine reductase; Region: TIGR00276 693977003435 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 693977003436 HEAT repeats; Region: HEAT_2; pfam13646 693977003437 HEAT repeat; Region: HEAT; pfam02985 693977003438 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 693977003439 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 693977003440 adenylosuccinate lyase; Provisional; Region: PRK07492 693977003441 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 693977003442 tetramer interface [polypeptide binding]; other site 693977003443 active site 693977003444 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 693977003445 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 693977003446 active site 693977003447 HIGH motif; other site 693977003448 KMSKS motif; other site 693977003449 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 693977003450 tRNA binding surface [nucleotide binding]; other site 693977003451 anticodon binding site; other site 693977003452 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 693977003453 dimer interface [polypeptide binding]; other site 693977003454 putative tRNA-binding site [nucleotide binding]; other site 693977003455 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 693977003456 Chloramphenicol acetyltransferase; Region: CAT; smart01059 693977003457 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693977003458 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693977003459 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693977003460 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 693977003461 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 693977003462 metal ion-dependent adhesion site (MIDAS); other site 693977003463 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 693977003464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693977003465 Mg2+ binding site [ion binding]; other site 693977003466 G-X-G motif; other site 693977003467 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 693977003468 anchoring element; other site 693977003469 dimer interface [polypeptide binding]; other site 693977003470 ATP binding site [chemical binding]; other site 693977003471 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 693977003472 active site 693977003473 putative metal-binding site [ion binding]; other site 693977003474 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 693977003475 BioY family; Region: BioY; pfam02632 693977003476 HTH domain; Region: HTH_11; cl17392 693977003477 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 693977003478 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 693977003479 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 693977003480 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 693977003481 metal binding site 2 [ion binding]; metal-binding site 693977003482 putative DNA binding helix; other site 693977003483 metal binding site 1 [ion binding]; metal-binding site 693977003484 dimer interface [polypeptide binding]; other site 693977003485 structural Zn2+ binding site [ion binding]; other site 693977003486 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 693977003487 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 693977003488 active site 693977003489 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 693977003490 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 693977003491 active site 693977003492 nucleophile elbow; other site 693977003493 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693977003494 E3 interaction surface; other site 693977003495 lipoyl attachment site [posttranslational modification]; other site 693977003496 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693977003497 E3 interaction surface; other site 693977003498 lipoyl attachment site [posttranslational modification]; other site 693977003499 e3 binding domain; Region: E3_binding; pfam02817 693977003500 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 693977003501 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 693977003502 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 693977003503 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 693977003504 dimer interface [polypeptide binding]; other site 693977003505 TPP-binding site [chemical binding]; other site 693977003506 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 693977003507 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 693977003508 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 693977003509 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693977003510 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 693977003511 dimerization interface [polypeptide binding]; other site 693977003512 substrate binding pocket [chemical binding]; other site 693977003513 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 693977003514 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 693977003515 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 693977003516 quinone interaction residues [chemical binding]; other site 693977003517 active site 693977003518 catalytic residues [active] 693977003519 FMN binding site [chemical binding]; other site 693977003520 substrate binding site [chemical binding]; other site 693977003521 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 693977003522 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 693977003523 active site 693977003524 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 693977003525 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 693977003526 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 693977003527 Ligand Binding Site [chemical binding]; other site 693977003528 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 693977003529 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13829 693977003530 RimM N-terminal domain; Region: RimM; pfam01782 693977003531 PRC-barrel domain; Region: PRC; pfam05239 693977003532 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 693977003533 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 693977003534 G-X-X-G motif; other site 693977003535 tRNA pseudouridine synthase B; Provisional; Region: PRK14122 693977003536 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 693977003537 RNA binding site [nucleotide binding]; other site 693977003538 active site 693977003539 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 693977003540 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693977003541 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 693977003542 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 693977003543 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 693977003544 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 693977003545 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 693977003546 MPN+ (JAMM) motif; other site 693977003547 Zinc-binding site [ion binding]; other site 693977003548 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 693977003549 Cation efflux family; Region: Cation_efflux; pfam01545 693977003550 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693977003551 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 693977003552 dimer interface [polypeptide binding]; other site 693977003553 putative metal binding site [ion binding]; other site 693977003554 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 693977003555 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 693977003556 23S rRNA binding site [nucleotide binding]; other site 693977003557 L21 binding site [polypeptide binding]; other site 693977003558 L13 binding site [polypeptide binding]; other site 693977003559 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 693977003560 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 693977003561 CutC family; Region: CutC; cl01218 693977003562 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 693977003563 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693977003564 active site 693977003565 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 693977003566 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 693977003567 Soluble P-type ATPase [General function prediction only]; Region: COG4087 693977003568 Haem-binding domain; Region: Haem_bd; pfam14376 693977003569 TPR repeat; Region: TPR_11; pfam13414 693977003570 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693977003571 TPR motif; other site 693977003572 binding surface 693977003573 TPR repeat; Region: TPR_11; pfam13414 693977003574 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693977003575 binding surface 693977003576 TPR motif; other site 693977003577 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 693977003578 TPR motif; other site 693977003579 binding surface 693977003580 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 693977003581 putative active site [active] 693977003582 dimerization interface [polypeptide binding]; other site 693977003583 putative tRNAtyr binding site [nucleotide binding]; other site 693977003584 Domain of unknown function (DUF1844); Region: DUF1844; pfam08899 693977003585 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 693977003586 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 693977003587 malonyl-CoA binding site [chemical binding]; other site 693977003588 dimer interface [polypeptide binding]; other site 693977003589 active site 693977003590 product binding site; other site 693977003591 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693977003592 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 693977003593 active site 693977003594 catalytic tetrad [active] 693977003595 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 693977003596 FMN binding site [chemical binding]; other site 693977003597 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 693977003598 dimer interface [polypeptide binding]; other site 693977003599 metabolite-proton symporter; Region: 2A0106; TIGR00883 693977003600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693977003601 putative substrate translocation pore; other site 693977003602 ornithine cyclodeaminase; Validated; Region: PRK08618 693977003603 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 693977003604 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 693977003605 active site 693977003606 multimer interface [polypeptide binding]; other site 693977003607 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 693977003608 Domain of unknown function DUF20; Region: UPF0118; pfam01594 693977003609 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693977003610 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 693977003611 active site 693977003612 metal binding site [ion binding]; metal-binding site 693977003613 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 693977003614 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 693977003615 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693977003616 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 693977003617 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 693977003618 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 693977003619 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 693977003620 dimerization interface [polypeptide binding]; other site 693977003621 domain crossover interface; other site 693977003622 redox-dependent activation switch; other site 693977003623 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 693977003624 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 693977003625 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 693977003626 active site 693977003627 dimer interface [polypeptide binding]; other site 693977003628 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 693977003629 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 693977003630 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693977003631 Peptidase M16C associated; Region: M16C_assoc; pfam08367 693977003632 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693977003633 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693977003634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693977003635 active site 693977003636 phosphorylation site [posttranslational modification] 693977003637 intermolecular recognition site; other site 693977003638 dimerization interface [polypeptide binding]; other site 693977003639 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693977003640 DNA binding site [nucleotide binding] 693977003641 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 693977003642 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 693977003643 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 693977003644 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 693977003645 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 693977003646 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 693977003647 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 693977003648 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 693977003649 oligomer interface [polypeptide binding]; other site 693977003650 active site residues [active] 693977003651 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 693977003652 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 693977003653 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693977003654 Walker A motif; other site 693977003655 ATP binding site [chemical binding]; other site 693977003656 Walker B motif; other site 693977003657 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 693977003658 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 693977003659 Found in ATP-dependent protease La (LON); Region: LON; smart00464 693977003660 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693977003661 Walker A motif; other site 693977003662 ATP binding site [chemical binding]; other site 693977003663 Walker B motif; other site 693977003664 arginine finger; other site 693977003665 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 693977003666 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 693977003667 SPOC domain; Region: SPOC; pfam07744 693977003668 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 693977003669 Walker A motif; other site 693977003670 ATP binding site [chemical binding]; other site 693977003671 Walker B motif; other site 693977003672 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 693977003673 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 693977003674 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 693977003675 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 693977003676 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 693977003677 Walker A motif; other site 693977003678 ATP binding site [chemical binding]; other site 693977003679 Walker B motif; other site 693977003680 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 693977003681 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693977003682 motif II; other site 693977003683 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 693977003684 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 693977003685 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 693977003686 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 693977003687 NAD binding site [chemical binding]; other site 693977003688 homotetramer interface [polypeptide binding]; other site 693977003689 homodimer interface [polypeptide binding]; other site 693977003690 substrate binding site [chemical binding]; other site 693977003691 active site 693977003692 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 693977003693 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 693977003694 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 693977003695 metal binding site [ion binding]; metal-binding site 693977003696 Neisseria meningitidis TspB protein; Region: Neisseria_TspB; pfam05616 693977003697 Predicted metalloprotease [General function prediction only]; Region: COG2321 693977003698 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 693977003699 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 693977003700 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 693977003701 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693977003702 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693977003703 E3 interaction surface; other site 693977003704 lipoyl attachment site [posttranslational modification]; other site 693977003705 HlyD family secretion protein; Region: HlyD_3; pfam13437 693977003706 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693977003707 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693977003708 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 693977003709 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693977003710 Walker A/P-loop; other site 693977003711 ATP binding site [chemical binding]; other site 693977003712 Q-loop/lid; other site 693977003713 ABC transporter signature motif; other site 693977003714 Walker B; other site 693977003715 D-loop; other site 693977003716 H-loop/switch region; other site 693977003717 TOBE domain; Region: TOBE_2; pfam08402 693977003718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 693977003719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693977003720 dimer interface [polypeptide binding]; other site 693977003721 conserved gate region; other site 693977003722 putative PBP binding loops; other site 693977003723 ABC-ATPase subunit interface; other site 693977003724 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 693977003725 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 693977003726 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 693977003727 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 693977003728 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693977003729 Uncharacterized conserved protein [Function unknown]; Region: COG5316 693977003730 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 693977003731 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 693977003732 Uncharacterized conserved protein [Function unknown]; Region: COG5316 693977003733 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 693977003734 Protein of unknown function (DUF805); Region: DUF805; pfam05656 693977003735 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 693977003736 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693977003737 Walker A/P-loop; other site 693977003738 ATP binding site [chemical binding]; other site 693977003739 Q-loop/lid; other site 693977003740 ABC transporter signature motif; other site 693977003741 Walker B; other site 693977003742 D-loop; other site 693977003743 H-loop/switch region; other site 693977003744 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693977003745 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 693977003746 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693977003747 Walker A/P-loop; other site 693977003748 ATP binding site [chemical binding]; other site 693977003749 Q-loop/lid; other site 693977003750 ABC transporter signature motif; other site 693977003751 Walker B; other site 693977003752 D-loop; other site 693977003753 H-loop/switch region; other site 693977003754 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693977003755 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 693977003756 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 693977003757 Putative zinc ribbon domain; Region: DUF164; pfam02591 693977003758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693977003759 putative substrate translocation pore; other site 693977003760 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693977003761 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 693977003762 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 693977003763 minor groove reading motif; other site 693977003764 helix-hairpin-helix signature motif; other site 693977003765 substrate binding pocket [chemical binding]; other site 693977003766 active site 693977003767 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 693977003768 Septum formation initiator; Region: DivIC; cl17659 693977003769 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 693977003770 TrkA-C domain; Region: TrkA_C; pfam02080 693977003771 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 693977003772 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 693977003773 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693977003774 nucleotide binding region [chemical binding]; other site 693977003775 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 693977003776 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 693977003777 active site 693977003778 nucleotide binding site [chemical binding]; other site 693977003779 HIGH motif; other site 693977003780 KMSKS motif; other site 693977003781 Type III pantothenate kinase; Region: Pan_kinase; cl17198 693977003782 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 693977003783 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 693977003784 acyl-activating enzyme (AAE) consensus motif; other site 693977003785 AMP binding site [chemical binding]; other site 693977003786 active site 693977003787 CoA binding site [chemical binding]; other site 693977003788 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 693977003789 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 693977003790 Predicted amidohydrolase [General function prediction only]; Region: COG0388 693977003791 active site 693977003792 catalytic triad [active] 693977003793 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 693977003794 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 693977003795 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 693977003796 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 693977003797 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 693977003798 carboxyltransferase (CT) interaction site; other site 693977003799 biotinylation site [posttranslational modification]; other site 693977003800 elongation factor P; Validated; Region: PRK00529 693977003801 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 693977003802 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 693977003803 RNA binding site [nucleotide binding]; other site 693977003804 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 693977003805 RNA binding site [nucleotide binding]; other site 693977003806 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 693977003807 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 693977003808 5S rRNA interface [nucleotide binding]; other site 693977003809 CTC domain interface [polypeptide binding]; other site 693977003810 L16 interface [polypeptide binding]; other site 693977003811 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 693977003812 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693977003813 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 693977003814 V4R domain; Region: V4R; cl15268 693977003815 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 693977003816 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693977003817 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693977003818 homodimer interface [polypeptide binding]; other site 693977003819 catalytic residue [active] 693977003820 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 693977003821 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 693977003822 HD domain; Region: HD_3; pfam13023 693977003823 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 693977003824 FeS assembly protein SufD; Region: sufD; TIGR01981 693977003825 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 693977003826 FeS assembly protein SufB; Region: sufB; TIGR01980 693977003827 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 693977003828 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 693977003829 Walker A/P-loop; other site 693977003830 ATP binding site [chemical binding]; other site 693977003831 Q-loop/lid; other site 693977003832 ABC transporter signature motif; other site 693977003833 Walker B; other site 693977003834 D-loop; other site 693977003835 H-loop/switch region; other site 693977003836 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 693977003837 Protein of unknown function DUF58; Region: DUF58; pfam01882 693977003838 MoxR-like ATPases [General function prediction only]; Region: COG0714 693977003839 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693977003840 ATP binding site [chemical binding]; other site 693977003841 Walker A motif; other site 693977003842 Walker B motif; other site 693977003843 arginine finger; other site 693977003844 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 693977003845 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 693977003846 CoenzymeA binding site [chemical binding]; other site 693977003847 subunit interaction site [polypeptide binding]; other site 693977003848 PHB binding site; other site 693977003849 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 693977003850 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 693977003851 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693977003852 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 693977003853 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693977003854 DNA binding residues [nucleotide binding] 693977003855 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 693977003856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693977003857 S-adenosylmethionine binding site [chemical binding]; other site 693977003858 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693977003859 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693977003860 metal binding site [ion binding]; metal-binding site 693977003861 active site 693977003862 I-site; other site 693977003863 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693977003864 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693977003865 metal binding site [ion binding]; metal-binding site 693977003866 active site 693977003867 I-site; other site 693977003868 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 693977003869 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 693977003870 active site 693977003871 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693977003872 substrate binding site [chemical binding]; other site 693977003873 catalytic residues [active] 693977003874 dimer interface [polypeptide binding]; other site 693977003875 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 693977003876 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693977003877 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693977003878 homodimer interface [polypeptide binding]; other site 693977003879 catalytic residue [active] 693977003880 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 693977003881 dihydrodipicolinate synthase; Region: dapA; TIGR00674 693977003882 dimer interface [polypeptide binding]; other site 693977003883 active site 693977003884 catalytic residue [active] 693977003885 dihydrodipicolinate reductase; Provisional; Region: PRK00048 693977003886 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 693977003887 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 693977003888 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 693977003889 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 693977003890 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693977003891 catalytic residue [active] 693977003892 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 693977003893 AAA domain; Region: AAA_30; pfam13604 693977003894 Family description; Region: UvrD_C_2; pfam13538 693977003895 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 693977003896 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 693977003897 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 693977003898 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 693977003899 active site 693977003900 metal binding site [ion binding]; metal-binding site 693977003901 DNA binding site [nucleotide binding] 693977003902 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 693977003903 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 693977003904 Walker A/P-loop; other site 693977003905 ATP binding site [chemical binding]; other site 693977003906 Q-loop/lid; other site 693977003907 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 693977003908 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693977003909 ABC transporter signature motif; other site 693977003910 Walker B; other site 693977003911 D-loop; other site 693977003912 H-loop/switch region; other site 693977003913 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693977003914 active site 693977003915 phytoene desaturase; Region: crtI_fam; TIGR02734 693977003916 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 693977003917 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 693977003918 putative active site [active] 693977003919 tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723 693977003920 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 693977003921 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 693977003922 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 693977003923 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 693977003924 phosphoglucomutase; Validated; Region: PRK07564 693977003925 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 693977003926 active site 693977003927 substrate binding site [chemical binding]; other site 693977003928 metal binding site [ion binding]; metal-binding site 693977003929 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 693977003930 GTP binding site; other site 693977003931 acylphosphatase; Provisional; Region: PRK14433 693977003932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693977003933 S-adenosylmethionine binding site [chemical binding]; other site 693977003934 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 693977003935 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 693977003936 dihydroorotase; Validated; Region: pyrC; PRK09357 693977003937 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693977003938 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 693977003939 active site 693977003940 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 693977003941 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 693977003942 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 693977003943 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 693977003944 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693977003945 active site 693977003946 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 693977003947 methionine sulfoxide reductase A; Provisional; Region: PRK14054 693977003948 butyrate kinase; Provisional; Region: PRK03011 693977003949 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 693977003950 endonuclease III; Region: ENDO3c; smart00478 693977003951 minor groove reading motif; other site 693977003952 helix-hairpin-helix signature motif; other site 693977003953 substrate binding pocket [chemical binding]; other site 693977003954 active site 693977003955 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 693977003956 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 693977003957 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 693977003958 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 693977003959 DNA binding residues [nucleotide binding] 693977003960 dimer interface [polypeptide binding]; other site 693977003961 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 693977003962 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 693977003963 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 693977003964 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 693977003965 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14173 693977003966 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 693977003967 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 693977003968 homodimer interface [polypeptide binding]; other site 693977003969 NADP binding site [chemical binding]; other site 693977003970 substrate binding site [chemical binding]; other site 693977003971 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 693977003972 Asp23 family; Region: Asp23; pfam03780 693977003973 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693977003974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693977003975 dimer interface [polypeptide binding]; other site 693977003976 conserved gate region; other site 693977003977 putative PBP binding loops; other site 693977003978 ABC-ATPase subunit interface; other site 693977003979 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 693977003980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693977003981 dimer interface [polypeptide binding]; other site 693977003982 conserved gate region; other site 693977003983 putative PBP binding loops; other site 693977003984 ABC-ATPase subunit interface; other site 693977003985 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 693977003986 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 693977003987 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 693977003988 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 693977003989 tRNA; other site 693977003990 putative tRNA binding site [nucleotide binding]; other site 693977003991 putative NADP binding site [chemical binding]; other site 693977003992 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 693977003993 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 693977003994 active site 693977003995 GTP-binding protein Der; Reviewed; Region: PRK00093 693977003996 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 693977003997 G1 box; other site 693977003998 GTP/Mg2+ binding site [chemical binding]; other site 693977003999 Switch I region; other site 693977004000 G2 box; other site 693977004001 Switch II region; other site 693977004002 G3 box; other site 693977004003 G4 box; other site 693977004004 G5 box; other site 693977004005 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 693977004006 G1 box; other site 693977004007 GTP/Mg2+ binding site [chemical binding]; other site 693977004008 Switch I region; other site 693977004009 G2 box; other site 693977004010 G3 box; other site 693977004011 Switch II region; other site 693977004012 G4 box; other site 693977004013 G5 box; other site 693977004014 elongation factor G; Reviewed; Region: PRK00007 693977004015 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 693977004016 G1 box; other site 693977004017 putative GEF interaction site [polypeptide binding]; other site 693977004018 GTP/Mg2+ binding site [chemical binding]; other site 693977004019 Switch I region; other site 693977004020 G2 box; other site 693977004021 G3 box; other site 693977004022 Switch II region; other site 693977004023 G4 box; other site 693977004024 G5 box; other site 693977004025 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 693977004026 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 693977004027 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 693977004028 30S ribosomal protein S7; Validated; Region: PRK05302 693977004029 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 693977004030 S17 interaction site [polypeptide binding]; other site 693977004031 S8 interaction site; other site 693977004032 16S rRNA interaction site [nucleotide binding]; other site 693977004033 streptomycin interaction site [chemical binding]; other site 693977004034 23S rRNA interaction site [nucleotide binding]; other site 693977004035 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 693977004036 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 693977004037 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693977004038 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 693977004039 Walker A/P-loop; other site 693977004040 ATP binding site [chemical binding]; other site 693977004041 Q-loop/lid; other site 693977004042 ABC transporter signature motif; other site 693977004043 Walker B; other site 693977004044 D-loop; other site 693977004045 H-loop/switch region; other site 693977004046 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 693977004047 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693977004048 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693977004049 Walker A/P-loop; other site 693977004050 ATP binding site [chemical binding]; other site 693977004051 Q-loop/lid; other site 693977004052 ABC transporter signature motif; other site 693977004053 Walker B; other site 693977004054 D-loop; other site 693977004055 H-loop/switch region; other site 693977004056 elongation factor Tu; Reviewed; Region: PRK00049 693977004057 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 693977004058 G1 box; other site 693977004059 GEF interaction site [polypeptide binding]; other site 693977004060 GTP/Mg2+ binding site [chemical binding]; other site 693977004061 Switch I region; other site 693977004062 G2 box; other site 693977004063 G3 box; other site 693977004064 Switch II region; other site 693977004065 G4 box; other site 693977004066 G5 box; other site 693977004067 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 693977004068 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 693977004069 Antibiotic Binding Site [chemical binding]; other site 693977004070 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 693977004071 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 693977004072 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 693977004073 RNA binding site [nucleotide binding]; other site 693977004074 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 693977004075 RNA binding site [nucleotide binding]; other site 693977004076 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 693977004077 RNA binding site [nucleotide binding]; other site 693977004078 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 693977004079 RNA binding site [nucleotide binding]; other site 693977004080 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 693977004081 RNA binding site [nucleotide binding]; other site 693977004082 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 693977004083 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 693977004084 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693977004085 substrate binding site [chemical binding]; other site 693977004086 oxyanion hole (OAH) forming residues; other site 693977004087 trimer interface [polypeptide binding]; other site 693977004088 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 693977004089 HD supefamily hydrolase [General function prediction only]; Region: COG3294 693977004090 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 693977004091 VanW like protein; Region: VanW; pfam04294 693977004092 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 693977004093 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 693977004094 FAD binding site [chemical binding]; other site 693977004095 homotetramer interface [polypeptide binding]; other site 693977004096 substrate binding pocket [chemical binding]; other site 693977004097 catalytic base [active] 693977004098 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 693977004099 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 693977004100 active site 693977004101 substrate binding site [chemical binding]; other site 693977004102 Mg2+ binding site [ion binding]; other site 693977004103 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 693977004104 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 693977004105 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 693977004106 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 693977004107 active site 693977004108 metal binding site [ion binding]; metal-binding site 693977004109 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 693977004110 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 693977004111 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 693977004112 P loop; other site 693977004113 GTP binding site [chemical binding]; other site 693977004114 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 693977004115 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 693977004116 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 693977004117 hypothetical protein; Provisional; Region: PRK08609 693977004118 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 693977004119 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 693977004120 active site 693977004121 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 693977004122 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 693977004123 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 693977004124 Catalytic site [active] 693977004125 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693977004126 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 693977004127 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 693977004128 substrate binding pocket [chemical binding]; other site 693977004129 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693977004130 GTP-binding protein LepA; Provisional; Region: PRK05433 693977004131 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 693977004132 G1 box; other site 693977004133 putative GEF interaction site [polypeptide binding]; other site 693977004134 GTP/Mg2+ binding site [chemical binding]; other site 693977004135 Switch I region; other site 693977004136 G2 box; other site 693977004137 G3 box; other site 693977004138 Switch II region; other site 693977004139 G4 box; other site 693977004140 G5 box; other site 693977004141 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 693977004142 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 693977004143 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 693977004144 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 693977004145 homotrimer interaction site [polypeptide binding]; other site 693977004146 putative active site [active] 693977004147 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 693977004148 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 693977004149 Na binding site [ion binding]; other site 693977004150 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 693977004151 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 693977004152 PSP1 C-terminal conserved region; Region: PSP1; cl00770 693977004153 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693977004154 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693977004155 DNA binding site [nucleotide binding] 693977004156 domain linker motif; other site 693977004157 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 693977004158 dimerization interface [polypeptide binding]; other site 693977004159 ligand binding site [chemical binding]; other site 693977004160 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 693977004161 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 693977004162 substrate binding site [chemical binding]; other site 693977004163 dimer interface [polypeptide binding]; other site 693977004164 ATP binding site [chemical binding]; other site 693977004165 D-ribose pyranase; Provisional; Region: PRK11797 693977004166 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 693977004167 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693977004168 Walker A/P-loop; other site 693977004169 ATP binding site [chemical binding]; other site 693977004170 Q-loop/lid; other site 693977004171 ABC transporter signature motif; other site 693977004172 Walker B; other site 693977004173 D-loop; other site 693977004174 H-loop/switch region; other site 693977004175 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693977004176 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693977004177 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 693977004178 TM-ABC transporter signature motif; other site 693977004179 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 693977004180 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 693977004181 ligand binding site [chemical binding]; other site 693977004182 dimerization interface [polypeptide binding]; other site 693977004183 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693977004184 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 693977004185 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 693977004186 metal ion-dependent adhesion site (MIDAS); other site 693977004187 Protein phosphatase 2C; Region: PP2C_2; pfam13672 693977004188 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 693977004189 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 693977004190 substrate binding site [chemical binding]; other site 693977004191 activation loop (A-loop); other site 693977004192 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 693977004193 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 693977004194 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693977004195 ATP binding site [chemical binding]; other site 693977004196 putative Mg++ binding site [ion binding]; other site 693977004197 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 693977004198 Protein of unknown function DUF262; Region: DUF262; pfam03235 693977004199 Uncharacterized conserved protein [Function unknown]; Region: COG1479 693977004200 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 693977004201 Uncharacterized conserved protein [Function unknown]; Region: COG3586 693977004202 HsdM N-terminal domain; Region: HsdM_N; pfam12161 693977004203 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 693977004204 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693977004205 S-adenosylmethionine binding site [chemical binding]; other site 693977004206 CGNR zinc finger; Region: zf-CGNR; pfam11706 693977004207 Helix-turn-helix domain; Region: HTH_17; pfam12728 693977004208 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 693977004209 HD domain; Region: HD_4; pfam13328 693977004210 Protein of unknown function DUF45; Region: DUF45; pfam01863 693977004211 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 693977004212 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 693977004213 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 693977004214 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 693977004215 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 693977004216 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 693977004217 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 693977004218 Abi-like protein; Region: Abi_2; pfam07751 693977004219 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 693977004220 HsdM N-terminal domain; Region: HsdM_N; pfam12161 693977004221 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 693977004222 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693977004223 non-specific DNA binding site [nucleotide binding]; other site 693977004224 salt bridge; other site 693977004225 sequence-specific DNA binding site [nucleotide binding]; other site 693977004226 integrase; Provisional; Region: int; PHA02601 693977004227 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 693977004228 Int/Topo IB signature motif; other site 693977004229 putative 4-hydroxybenzoate polyprenyltransferase; Region: ubiA_other; TIGR01475 693977004230 UbiA prenyltransferase family; Region: UbiA; pfam01040 693977004231 cyclase homology domain; Region: CHD; cd07302 693977004232 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 693977004233 nucleotidyl binding site; other site 693977004234 metal binding site [ion binding]; metal-binding site 693977004235 dimer interface [polypeptide binding]; other site 693977004236 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693977004237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693977004238 active site 693977004239 phosphorylation site [posttranslational modification] 693977004240 intermolecular recognition site; other site 693977004241 dimerization interface [polypeptide binding]; other site 693977004242 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693977004243 DNA binding site [nucleotide binding] 693977004244 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693977004245 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693977004246 dimerization interface [polypeptide binding]; other site 693977004247 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693977004248 dimer interface [polypeptide binding]; other site 693977004249 phosphorylation site [posttranslational modification] 693977004250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693977004251 ATP binding site [chemical binding]; other site 693977004252 Mg2+ binding site [ion binding]; other site 693977004253 G-X-G motif; other site 693977004254 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 693977004255 arginine repressor; Region: argR_whole; TIGR01529 693977004256 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 693977004257 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 693977004258 Flavoprotein; Region: Flavoprotein; pfam02441 693977004259 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 693977004260 FtsH Extracellular; Region: FtsH_ext; pfam06480 693977004261 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 693977004262 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693977004263 Walker A motif; other site 693977004264 ATP binding site [chemical binding]; other site 693977004265 Walker B motif; other site 693977004266 arginine finger; other site 693977004267 Peptidase family M41; Region: Peptidase_M41; pfam01434 693977004268 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 693977004269 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 693977004270 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693977004271 catalytic residue [active] 693977004272 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 693977004273 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 693977004274 homodimer interface [polypeptide binding]; other site 693977004275 substrate-cofactor binding pocket; other site 693977004276 catalytic residue [active] 693977004277 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 693977004278 dimer interface [polypeptide binding]; other site 693977004279 ADP-ribose binding site [chemical binding]; other site 693977004280 active site 693977004281 nudix motif; other site 693977004282 metal binding site [ion binding]; metal-binding site 693977004283 Uncharacterized conserved protein [Function unknown]; Region: COG1739 693977004284 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 693977004285 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 693977004286 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 693977004287 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 693977004288 trmE is a tRNA modification GTPase; Region: trmE; cd04164 693977004289 G1 box; other site 693977004290 GTP/Mg2+ binding site [chemical binding]; other site 693977004291 Switch I region; other site 693977004292 G2 box; other site 693977004293 Switch II region; other site 693977004294 G3 box; other site 693977004295 G4 box; other site 693977004296 G5 box; other site 693977004297 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 693977004298 topology modulation protein; Reviewed; Region: PRK08118 693977004299 AAA domain; Region: AAA_17; pfam13207 693977004300 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 693977004301 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 693977004302 Peptidase family U32; Region: Peptidase_U32; pfam01136 693977004303 Collagenase; Region: DUF3656; pfam12392 693977004304 Quinolinate phosphoribosyl transferase, C-terminal domain; Region: QRPTase_C; pfam01729 693977004305 Peptidase family U32; Region: Peptidase_U32; cl03113 693977004306 Nuclease-related domain; Region: NERD; pfam08378 693977004307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693977004308 putative substrate translocation pore; other site 693977004309 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693977004310 Peptidase M14 Carboxypeptidase T-like subfamily; Region: M14_CPT_like; cd06226 693977004311 putative active site [active] 693977004312 Zn binding site [ion binding]; other site 693977004313 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: PspE; COG0607 693977004314 active site residue [active] 693977004315 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 693977004316 active site residue [active] 693977004317 Domain of unknown function DUF59; Region: DUF59; cl00941 693977004318 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 693977004319 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 693977004320 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 693977004321 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693977004322 catalytic residue [active] 693977004323 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 693977004324 malate synthase A; Region: malate_syn_A; TIGR01344 693977004325 active site 693977004326 isocitrate lyase; Provisional; Region: PRK15063 693977004327 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 693977004328 tetramer interface [polypeptide binding]; other site 693977004329 active site 693977004330 Mg2+/Mn2+ binding site [ion binding]; other site 693977004331 acetyl-CoA synthetase; Provisional; Region: PRK00174 693977004332 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 693977004333 active site 693977004334 CoA binding site [chemical binding]; other site 693977004335 acyl-activating enzyme (AAE) consensus motif; other site 693977004336 AMP binding site [chemical binding]; other site 693977004337 acetate binding site [chemical binding]; other site 693977004338 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 693977004339 Cytochrome P450; Region: p450; cl12078 693977004340 AAA domain; Region: AAA_33; pfam13671 693977004341 glycyl-tRNA synthetase; Provisional; Region: PRK04173 693977004342 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 693977004343 motif 1; other site 693977004344 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 693977004345 active site 693977004346 motif 2; other site 693977004347 motif 3; other site 693977004348 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 693977004349 anticodon binding site; other site 693977004350 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 693977004351 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 693977004352 Ligand binding site [chemical binding]; other site 693977004353 Electron transfer flavoprotein domain; Region: ETF; pfam01012 693977004354 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 693977004355 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 693977004356 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 693977004357 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 693977004358 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 693977004359 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 693977004360 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 693977004361 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 693977004362 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 693977004363 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 693977004364 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 693977004365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 693977004366 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 693977004367 RNA/DNA hybrid binding site [nucleotide binding]; other site 693977004368 active site 693977004369 Predicted transcriptional regulators [Transcription]; Region: COG1378 693977004370 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 693977004371 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 693977004372 C-terminal domain interface [polypeptide binding]; other site 693977004373 sugar binding site [chemical binding]; other site 693977004374 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693977004375 S-adenosylmethionine binding site [chemical binding]; other site 693977004376 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 693977004377 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 693977004378 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 693977004379 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 693977004380 putative active site [active] 693977004381 putative FMN binding site [chemical binding]; other site 693977004382 putative substrate binding site [chemical binding]; other site 693977004383 putative catalytic residue [active] 693977004384 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 693977004385 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 693977004386 substrate binding pocket [chemical binding]; other site 693977004387 catalytic triad [active] 693977004388 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 693977004389 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 693977004390 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 693977004391 catalytic triad [active] 693977004392 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642 693977004393 Peptidase family M28; Region: Peptidase_M28; pfam04389 693977004394 putative metal binding site [ion binding]; other site 693977004395 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 693977004396 Interdomain contacts; other site 693977004397 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 693977004398 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 693977004399 Active site serine [active] 693977004400 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 693977004401 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 693977004402 putative tRNA-binding site [nucleotide binding]; other site 693977004403 B3/4 domain; Region: B3_4; pfam03483 693977004404 tRNA synthetase B5 domain; Region: B5; smart00874 693977004405 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 693977004406 dimer interface [polypeptide binding]; other site 693977004407 motif 1; other site 693977004408 motif 3; other site 693977004409 motif 2; other site 693977004410 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 693977004411 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 693977004412 nudix motif; other site 693977004413 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 693977004414 nudix motif; other site 693977004415 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 693977004416 putative active site pocket [active] 693977004417 dimerization interface [polypeptide binding]; other site 693977004418 putative catalytic residue [active] 693977004419 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 693977004420 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 693977004421 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 693977004422 dimer interface [polypeptide binding]; other site 693977004423 motif 1; other site 693977004424 active site 693977004425 motif 2; other site 693977004426 motif 3; other site 693977004427 potassium/proton antiporter; Reviewed; Region: PRK05326 693977004428 TrkA-C domain; Region: TrkA_C; pfam02080 693977004429 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 693977004430 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 693977004431 dimer interface [polypeptide binding]; other site 693977004432 active site 693977004433 glycine-pyridoxal phosphate binding site [chemical binding]; other site 693977004434 folate binding site [chemical binding]; other site 693977004435 V4R domain; Region: V4R; cl15268 693977004436 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 693977004437 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693977004438 dimerization interface [polypeptide binding]; other site 693977004439 putative DNA binding site [nucleotide binding]; other site 693977004440 putative Zn2+ binding site [ion binding]; other site 693977004441 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 693977004442 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 693977004443 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 693977004444 homotrimer interaction site [polypeptide binding]; other site 693977004445 zinc binding site [ion binding]; other site 693977004446 CDP-binding sites; other site 693977004447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 693977004448 Family of unknown function (DUF490); Region: DUF490; pfam04357 693977004449 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693977004450 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693977004451 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 693977004452 Walker A/P-loop; other site 693977004453 ATP binding site [chemical binding]; other site 693977004454 Q-loop/lid; other site 693977004455 ABC transporter signature motif; other site 693977004456 Walker B; other site 693977004457 D-loop; other site 693977004458 H-loop/switch region; other site 693977004459 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 693977004460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693977004461 ATP binding site [chemical binding]; other site 693977004462 Mg2+ binding site [ion binding]; other site 693977004463 G-X-G motif; other site 693977004464 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 693977004465 ATP binding site [chemical binding]; other site 693977004466 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 693977004467 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 693977004468 MutS domain I; Region: MutS_I; pfam01624 693977004469 MutS domain II; Region: MutS_II; pfam05188 693977004470 MutS domain III; Region: MutS_III; pfam05192 693977004471 MutS domain V; Region: MutS_V; pfam00488 693977004472 Walker A/P-loop; other site 693977004473 ATP binding site [chemical binding]; other site 693977004474 Q-loop/lid; other site 693977004475 ABC transporter signature motif; other site 693977004476 Walker B; other site 693977004477 D-loop; other site 693977004478 H-loop/switch region; other site 693977004479 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 693977004480 23S rRNA interface [nucleotide binding]; other site 693977004481 L3 interface [polypeptide binding]; other site 693977004482 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 693977004483 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 693977004484 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 693977004485 active site 693977004486 motif I; other site 693977004487 motif II; other site 693977004488 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 693977004489 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 693977004490 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693977004491 active site 693977004492 motif I; other site 693977004493 motif II; other site 693977004494 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 693977004495 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693977004496 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 693977004497 trimer interface [polypeptide binding]; other site 693977004498 active site 693977004499 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 693977004500 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693977004501 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 693977004502 lipoyl synthase; Provisional; Region: PRK05481 693977004503 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693977004504 FeS/SAM binding site; other site 693977004505 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 693977004506 EamA-like transporter family; Region: EamA; pfam00892 693977004507 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 693977004508 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 693977004509 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693977004510 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 693977004511 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 693977004512 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 693977004513 dimerization interface [polypeptide binding]; other site 693977004514 active site 693977004515 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 693977004516 Lumazine binding domain; Region: Lum_binding; pfam00677 693977004517 Lumazine binding domain; Region: Lum_binding; pfam00677 693977004518 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 693977004519 catalytic motif [active] 693977004520 Zn binding site [ion binding]; other site 693977004521 RibD C-terminal domain; Region: RibD_C; cl17279 693977004522 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 693977004523 RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885 693977004524 Predicted type IV restriction endonuclease [Defense mechanisms]; Region: COG2810 693977004525 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 693977004526 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 693977004527 S-adenosylmethionine synthetase; Validated; Region: PRK05250 693977004528 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 693977004529 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 693977004530 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 693977004531 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693977004532 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 693977004533 DdrB-like protein; Region: DdrB; pfam12747 693977004534 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 693977004535 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693977004536 NAD(P) binding site [chemical binding]; other site 693977004537 active site 693977004538 L-asparaginase II; Region: Asparaginase_II; pfam06089 693977004539 Protein of unknown function (DUF2283); Region: DUF2283; cl02251 693977004540 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 693977004541 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 693977004542 active site 693977004543 Zn binding site [ion binding]; other site 693977004544 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 693977004545 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 693977004546 active site 693977004547 metal binding site [ion binding]; metal-binding site 693977004548 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 693977004549 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 693977004550 classical (c) SDRs; Region: SDR_c; cd05233 693977004551 NAD(P) binding site [chemical binding]; other site 693977004552 active site 693977004553 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 693977004554 DNA polymerase III subunit delta'; Validated; Region: PRK08485 693977004555 DinB superfamily; Region: DinB_2; pfam12867 693977004556 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 693977004557 dimer interface [polypeptide binding]; other site 693977004558 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693977004559 ligand binding site [chemical binding]; other site 693977004560 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 693977004561 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 693977004562 Predicted integral membrane protein (DUF2270); Region: DUF2270; cl02337 693977004563 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14612 693977004564 PIN domain; Region: PIN; pfam01850 693977004565 putative active site [active] 693977004566 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 693977004567 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 693977004568 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 693977004569 substrate binding site; other site 693977004570 dimer interface; other site 693977004571 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 693977004572 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693977004573 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693977004574 Coenzyme A binding pocket [chemical binding]; other site 693977004575 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 693977004576 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693977004577 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 693977004578 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693977004579 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693977004580 ABC transporter; Region: ABC_tran_2; pfam12848 693977004581 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 693977004582 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 693977004583 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 693977004584 Flavoprotein; Region: Flavoprotein; pfam02441 693977004585 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 693977004586 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 693977004587 active site 693977004588 Zn binding site [ion binding]; other site 693977004589 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693977004590 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 693977004591 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 693977004592 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 693977004593 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 693977004594 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 693977004595 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 693977004596 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 693977004597 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 693977004598 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 693977004599 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 693977004600 active site 693977004601 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 693977004602 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 693977004603 Excalibur calcium-binding domain; Region: Excalibur; smart00894 693977004604 RNHCP domain; Region: RNHCP; pfam12647 693977004605 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 693977004606 MOSC domain; Region: MOSC; pfam03473 693977004607 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 693977004608 Domain of unknown function (DUF814); Region: DUF814; pfam05670 693977004609 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 693977004610 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693977004611 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 693977004612 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693977004613 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 693977004614 Surface antigen; Region: Bac_surface_Ag; pfam01103 693977004615 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 693977004616 transmembrane helices; other site 693977004617 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 693977004618 TrkA-C domain; Region: TrkA_C; pfam02080 693977004619 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 693977004620 TrkA-C domain; Region: TrkA_C; pfam02080 693977004621 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 693977004622 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 693977004623 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 693977004624 Helix-turn-helix domain; Region: HTH_28; pfam13518 693977004625 Winged helix-turn helix; Region: HTH_29; pfam13551 693977004626 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 693977004627 TniQ; Region: TniQ; pfam06527 693977004628 Winged helix-turn helix; Region: HTH_29; pfam13551 693977004629 Ethanolamine utilisation protein EutA; Region: EutA; pfam06277 693977004630 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 693977004631 DNA methylase; Region: N6_N4_Mtase; pfam01555 693977004632 DNA methylase; Region: N6_N4_Mtase; pfam01555 693977004633 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 693977004634 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 693977004635 Catalytic site [active] 693977004636 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 693977004637 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 693977004638 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 693977004639 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 693977004640 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 693977004641 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693977004642 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 693977004643 IHF - DNA interface [nucleotide binding]; other site 693977004644 IHF dimer interface [polypeptide binding]; other site 693977004645 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 693977004646 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 693977004647 ATP binding site [chemical binding]; other site 693977004648 substrate interface [chemical binding]; other site 693977004649 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 693977004650 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 693977004651 Uncharacterized metal-binding protein [General function prediction only]; Region: COG2389 693977004652 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 693977004653 Fe-S cluster binding site [ion binding]; other site 693977004654 active site 693977004655 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 693977004656 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693977004657 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 693977004658 NlpC/P60 family; Region: NLPC_P60; pfam00877 693977004659 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693977004660 EamA-like transporter family; Region: EamA; pfam00892 693977004661 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693977004662 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 693977004663 30S subunit binding site; other site 693977004664 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 693977004665 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 693977004666 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 693977004667 active site 693977004668 HIGH motif; other site 693977004669 KMSK motif region; other site 693977004670 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 693977004671 tRNA binding surface [nucleotide binding]; other site 693977004672 anticodon binding site; other site 693977004673 Predicted phosphohydrolase [General function prediction only]; Region: COG1768 693977004674 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 693977004675 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 693977004676 PhoU domain; Region: PhoU; pfam01895 693977004677 PhoU domain; Region: PhoU; pfam01895 693977004678 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 693977004679 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 693977004680 FMN binding site [chemical binding]; other site 693977004681 substrate binding site [chemical binding]; other site 693977004682 putative catalytic residue [active] 693977004683 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 693977004684 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 693977004685 Walker A/P-loop; other site 693977004686 ATP binding site [chemical binding]; other site 693977004687 Q-loop/lid; other site 693977004688 ABC transporter signature motif; other site 693977004689 Walker B; other site 693977004690 D-loop; other site 693977004691 H-loop/switch region; other site 693977004692 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 693977004693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693977004694 dimer interface [polypeptide binding]; other site 693977004695 conserved gate region; other site 693977004696 putative PBP binding loops; other site 693977004697 ABC-ATPase subunit interface; other site 693977004698 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 693977004699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693977004700 dimer interface [polypeptide binding]; other site 693977004701 conserved gate region; other site 693977004702 putative PBP binding loops; other site 693977004703 ABC-ATPase subunit interface; other site 693977004704 PBP superfamily domain; Region: PBP_like_2; cl17296 693977004705 Uncharacterized conserved protein [Function unknown]; Region: COG0327 693977004706 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 693977004707 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 693977004708 thymidylate kinase; Validated; Region: tmk; PRK00698 693977004709 TMP-binding site; other site 693977004710 ATP-binding site [chemical binding]; other site 693977004711 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 693977004712 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 693977004713 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 693977004714 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 693977004715 Walker A/P-loop; other site 693977004716 ATP binding site [chemical binding]; other site 693977004717 Q-loop/lid; other site 693977004718 ABC transporter signature motif; other site 693977004719 Walker B; other site 693977004720 D-loop; other site 693977004721 H-loop/switch region; other site 693977004722 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 693977004723 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 693977004724 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 693977004725 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 693977004726 4Fe-4S binding domain; Region: Fer4; pfam00037 693977004727 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 693977004728 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 693977004729 Catalytic domain of Protein Kinases; Region: PKc; cd00180 693977004730 active site 693977004731 ATP binding site [chemical binding]; other site 693977004732 substrate binding site [chemical binding]; other site 693977004733 activation loop (A-loop); other site 693977004734 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 693977004735 peptide chain release factor 2; Validated; Region: prfB; PRK00578 693977004736 PCRF domain; Region: PCRF; pfam03462 693977004737 RF-1 domain; Region: RF-1; pfam00472 693977004738 Flagellin N-methylase; Region: FliB; cl00497 693977004739 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 693977004740 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693977004741 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693977004742 homodimer interface [polypeptide binding]; other site 693977004743 catalytic residue [active] 693977004744 Predicted integral membrane protein [Function unknown]; Region: COG5637 693977004745 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 693977004746 putative hydrophobic ligand binding site [chemical binding]; other site 693977004747 EamA-like transporter family; Region: EamA; pfam00892 693977004748 EamA-like transporter family; Region: EamA; pfam00892 693977004749 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 693977004750 active site 693977004751 NTP binding site [chemical binding]; other site 693977004752 metal binding triad [ion binding]; metal-binding site 693977004753 antibiotic binding site [chemical binding]; other site 693977004754 Uncharacterized conserved protein [Function unknown]; Region: COG2361 693977004755 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 693977004756 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 693977004757 ring oligomerisation interface [polypeptide binding]; other site 693977004758 ATP/Mg binding site [chemical binding]; other site 693977004759 stacking interactions; other site 693977004760 hinge regions; other site 693977004761 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 693977004762 oligomerisation interface [polypeptide binding]; other site 693977004763 mobile loop; other site 693977004764 roof hairpin; other site 693977004765 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693977004766 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693977004767 metal binding site [ion binding]; metal-binding site 693977004768 active site 693977004769 I-site; other site 693977004770 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 693977004771 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693977004772 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 693977004773 active site 693977004774 catalytic residues [active] 693977004775 metal binding site [ion binding]; metal-binding site 693977004776 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 693977004777 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 693977004778 putative active site [active] 693977004779 substrate binding site [chemical binding]; other site 693977004780 putative cosubstrate binding site; other site 693977004781 catalytic site [active] 693977004782 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 693977004783 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cl00254 693977004784 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 693977004785 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 693977004786 minor groove reading motif; other site 693977004787 helix-hairpin-helix signature motif; other site 693977004788 active site 693977004789 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 693977004790 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693977004791 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 693977004792 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693977004793 homodimer interface [polypeptide binding]; other site 693977004794 catalytic residue [active] 693977004795 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 693977004796 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 693977004797 ligand binding site [chemical binding]; other site 693977004798 flexible hinge region; other site 693977004799 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 693977004800 putative switch regulator; other site 693977004801 non-specific DNA interactions [nucleotide binding]; other site 693977004802 DNA binding site [nucleotide binding] 693977004803 sequence specific DNA binding site [nucleotide binding]; other site 693977004804 putative cAMP binding site [chemical binding]; other site 693977004805 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 693977004806 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 693977004807 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 693977004808 active site 693977004809 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 693977004810 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 693977004811 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 693977004812 Cl binding site [ion binding]; other site 693977004813 oligomer interface [polypeptide binding]; other site 693977004814 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 693977004815 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 693977004816 VanW like protein; Region: VanW; pfam04294 693977004817 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 693977004818 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 693977004819 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693977004820 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693977004821 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693977004822 salt bridge; other site 693977004823 non-specific DNA binding site [nucleotide binding]; other site 693977004824 sequence-specific DNA binding site [nucleotide binding]; other site 693977004825 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 693977004826 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693977004827 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 693977004828 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 693977004829 Protein of unknown function (DUF422); Region: DUF422; pfam04240 693977004830 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 693977004831 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 693977004832 putative acyl-acceptor binding pocket; other site 693977004833 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693977004834 active site 693977004835 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 693977004836 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693977004837 active site 693977004838 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693977004839 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693977004840 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693977004841 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 693977004842 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 693977004843 Walker A/P-loop; other site 693977004844 ATP binding site [chemical binding]; other site 693977004845 Q-loop/lid; other site 693977004846 ABC transporter signature motif; other site 693977004847 Walker B; other site 693977004848 D-loop; other site 693977004849 H-loop/switch region; other site 693977004850 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 693977004851 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 693977004852 L-lactate permease; Region: Lactate_perm; cl00701 693977004853 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 693977004854 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 693977004855 generic binding surface II; other site 693977004856 generic binding surface I; other site 693977004857 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 693977004858 putative active site [active] 693977004859 putative catalytic site [active] 693977004860 putative Mg binding site IVb [ion binding]; other site 693977004861 putative phosphate binding site [ion binding]; other site 693977004862 putative DNA binding site [nucleotide binding]; other site 693977004863 putative Mg binding site IVa [ion binding]; other site 693977004864 fumarate hydratase; Reviewed; Region: fumC; PRK00485 693977004865 Class II fumarases; Region: Fumarase_classII; cd01362 693977004866 active site 693977004867 tetramer interface [polypeptide binding]; other site 693977004868 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 693977004869 putative active site [active] 693977004870 putative metal binding site [ion binding]; other site 693977004871 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 693977004872 Domain of unknown function (DUF305); Region: DUF305; pfam03713 693977004873 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 693977004874 RNB domain; Region: RNB; pfam00773 693977004875 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 693977004876 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693977004877 E3 interaction surface; other site 693977004878 lipoyl attachment site [posttranslational modification]; other site 693977004879 e3 binding domain; Region: E3_binding; pfam02817 693977004880 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 693977004881 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 693977004882 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 693977004883 TPP-binding site [chemical binding]; other site 693977004884 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 693977004885 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 693977004886 thymidylate synthase; Reviewed; Region: thyA; PRK01827 693977004887 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 693977004888 dimerization interface [polypeptide binding]; other site 693977004889 active site 693977004890 Deoxycytidylate deaminase [Nucleotide transport and metabolism]; Region: ComEB; COG2131 693977004891 active site 693977004892 Zn binding site [ion binding]; other site 693977004893 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 693977004894 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 693977004895 folate binding site [chemical binding]; other site 693977004896 NADP+ binding site [chemical binding]; other site 693977004897 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 693977004898 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 693977004899 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693977004900 Walker A motif; other site 693977004901 ATP binding site [chemical binding]; other site 693977004902 Walker B motif; other site 693977004903 arginine finger; other site 693977004904 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 693977004905 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 693977004906 putative active site; other site 693977004907 putative metal binding residues [ion binding]; other site 693977004908 signature motif; other site 693977004909 putative triphosphate binding site [ion binding]; other site 693977004910 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 693977004911 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 693977004912 Cu(I) binding site [ion binding]; other site 693977004913 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 693977004914 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 693977004915 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 693977004916 Subunit I/III interface [polypeptide binding]; other site 693977004917 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00185 693977004918 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 693977004919 Cytochrome c; Region: Cytochrom_C; cl11414 693977004920 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 693977004921 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 693977004922 UbiA prenyltransferase family; Region: UbiA; pfam01040 693977004923 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 693977004924 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 693977004925 YceG-like family; Region: YceG; pfam02618 693977004926 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 693977004927 dimerization interface [polypeptide binding]; other site 693977004928 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 693977004929 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 693977004930 Walker A; other site 693977004931 phosphopentomutase; Provisional; Region: PRK05362 693977004932 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 693977004933 Predicted membrane protein [Function unknown]; Region: COG2322 693977004934 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 693977004935 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 693977004936 Walker A/P-loop; other site 693977004937 ATP binding site [chemical binding]; other site 693977004938 Q-loop/lid; other site 693977004939 ABC transporter signature motif; other site 693977004940 Walker B; other site 693977004941 D-loop; other site 693977004942 H-loop/switch region; other site 693977004943 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 693977004944 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 693977004945 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 693977004946 glutaminase active site [active] 693977004947 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 693977004948 dimer interface [polypeptide binding]; other site 693977004949 active site 693977004950 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 693977004951 dimer interface [polypeptide binding]; other site 693977004952 active site 693977004953 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 693977004954 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 693977004955 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 693977004956 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 693977004957 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 693977004958 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 693977004959 active site 693977004960 P-loop; other site 693977004961 phosphorylation site [posttranslational modification] 693977004962 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 693977004963 active site 693977004964 phosphorylation site [posttranslational modification] 693977004965 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 693977004966 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 693977004967 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 693977004968 protein binding site [polypeptide binding]; other site 693977004969 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 693977004970 Zn2+ binding site [ion binding]; other site 693977004971 Mg2+ binding site [ion binding]; other site 693977004972 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 693977004973 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 693977004974 active site 693977004975 homodimer interface [polypeptide binding]; other site 693977004976 UDP-N-acetylmuramate--alanine ligase; Region: murC; TIGR01082 693977004977 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 693977004978 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693977004979 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693977004980 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14651 693977004981 FAD binding domain; Region: FAD_binding_4; pfam01565 693977004982 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 693977004983 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 693977004984 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 693977004985 cell division protein FtsA; Region: ftsA; TIGR01174 693977004986 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693977004987 nucleotide binding site [chemical binding]; other site 693977004988 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 693977004989 Cell division protein FtsA; Region: FtsA; pfam14450 693977004990 cell division protein FtsZ; Validated; Region: PRK09330 693977004991 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 693977004992 nucleotide binding site [chemical binding]; other site 693977004993 SulA interaction site; other site 693977004994 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 693977004995 catalytic residues [active] 693977004996 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 693977004997 polyphosphate kinase; Provisional; Region: PRK05443 693977004998 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 693977004999 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 693977005000 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 693977005001 putative domain interface [polypeptide binding]; other site 693977005002 putative active site [active] 693977005003 catalytic site [active] 693977005004 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 693977005005 putative domain interface [polypeptide binding]; other site 693977005006 putative active site [active] 693977005007 catalytic site [active] 693977005008 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 693977005009 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 693977005010 dimer interface [polypeptide binding]; other site 693977005011 active site 693977005012 acyl carrier protein; Provisional; Region: acpP; PRK00982 693977005013 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 693977005014 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 693977005015 NAD(P) binding site [chemical binding]; other site 693977005016 homotetramer interface [polypeptide binding]; other site 693977005017 homodimer interface [polypeptide binding]; other site 693977005018 active site 693977005019 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 693977005020 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 693977005021 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 693977005022 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 693977005023 dimer interface [polypeptide binding]; other site 693977005024 active site 693977005025 CoA binding pocket [chemical binding]; other site 693977005026 trigger factor; Region: tig; TIGR00115 693977005027 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 693977005028 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 693977005029 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693977005030 putative active site [active] 693977005031 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693977005032 heme pocket [chemical binding]; other site 693977005033 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693977005034 dimer interface [polypeptide binding]; other site 693977005035 phosphorylation site [posttranslational modification] 693977005036 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693977005037 ATP binding site [chemical binding]; other site 693977005038 Mg2+ binding site [ion binding]; other site 693977005039 G-X-G motif; other site 693977005040 Predicted membrane protein [Function unknown]; Region: COG2311 693977005041 Protein of unknown function (DUF418); Region: DUF418; cl12135 693977005042 Protein of unknown function (DUF418); Region: DUF418; pfam04235 693977005043 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 693977005044 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 693977005045 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 693977005046 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693977005047 ATP binding site [chemical binding]; other site 693977005048 putative Mg++ binding site [ion binding]; other site 693977005049 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693977005050 nucleotide binding region [chemical binding]; other site 693977005051 ATP-binding site [chemical binding]; other site 693977005052 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 693977005053 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 693977005054 PhoU domain; Region: PhoU; pfam01895 693977005055 PhoU domain; Region: PhoU; pfam01895 693977005056 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 693977005057 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 693977005058 nudix motif; other site 693977005059 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 693977005060 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693977005061 Walker A motif; other site 693977005062 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 693977005063 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 693977005064 protein-splicing catalytic site; other site 693977005065 thioester formation/cholesterol transfer; other site 693977005066 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 693977005067 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 693977005068 protein-splicing catalytic site; other site 693977005069 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 693977005070 ATP binding site [chemical binding]; other site 693977005071 Walker B motif; other site 693977005072 DNA binding loops [nucleotide binding] 693977005073 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 693977005074 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693977005075 S-adenosylmethionine binding site [chemical binding]; other site 693977005076 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 693977005077 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14618 693977005078 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 693977005079 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 693977005080 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693977005081 motif II; other site 693977005082 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 693977005083 nucleotide binding site/active site [active] 693977005084 HIT family signature motif; other site 693977005085 catalytic residue [active] 693977005086 short chain dehydrogenase; Provisional; Region: PRK06181 693977005087 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693977005088 NAD(P) binding site [chemical binding]; other site 693977005089 active site 693977005090 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 693977005091 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 693977005092 RNA methyltransferase, RsmE family; Region: TIGR00046 693977005093 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 693977005094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693977005095 S-adenosylmethionine binding site [chemical binding]; other site 693977005096 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 693977005097 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 693977005098 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693977005099 TAP-like protein; Region: Abhydrolase_4; pfam08386 693977005100 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 693977005101 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 693977005102 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 693977005103 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 693977005104 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 693977005105 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 693977005106 Recombination protein O N terminal; Region: RecO_N; pfam11967 693977005107 Recombination protein O C terminal; Region: RecO_C; pfam02565 693977005108 Proline dehydrogenase; Region: Pro_dh; cl03282 693977005109 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 693977005110 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 693977005111 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 693977005112 Glutamate binding site [chemical binding]; other site 693977005113 homodimer interface [polypeptide binding]; other site 693977005114 NAD binding site [chemical binding]; other site 693977005115 catalytic residues [active] 693977005116 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 693977005117 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 693977005118 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 693977005119 active site 693977005120 catalytic residues [active] 693977005121 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 693977005122 PA/protease or protease-like domain interface [polypeptide binding]; other site 693977005123 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 693977005124 catalytic residues [active] 693977005125 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 693977005126 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693977005127 Coenzyme A binding pocket [chemical binding]; other site 693977005128 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 693977005129 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 693977005130 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 693977005131 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 693977005132 alpha subunit interface [polypeptide binding]; other site 693977005133 TPP binding site [chemical binding]; other site 693977005134 heterodimer interface [polypeptide binding]; other site 693977005135 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 693977005136 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 693977005137 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 693977005138 tetramer interface [polypeptide binding]; other site 693977005139 TPP-binding site [chemical binding]; other site 693977005140 heterodimer interface [polypeptide binding]; other site 693977005141 phosphorylation loop region [posttranslational modification] 693977005142 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 693977005143 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 693977005144 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 693977005145 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 693977005146 homodimer interface [polypeptide binding]; other site 693977005147 NAD binding pocket [chemical binding]; other site 693977005148 ATP binding pocket [chemical binding]; other site 693977005149 Mg binding site [ion binding]; other site 693977005150 active-site loop [active] 693977005151 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 693977005152 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 693977005153 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 693977005154 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 693977005155 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 693977005156 active site 693977005157 metal binding site [ion binding]; metal-binding site 693977005158 hypothetical protein; Provisional; Region: PRK04164 693977005159 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 693977005160 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 693977005161 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 693977005162 metal binding site [ion binding]; metal-binding site 693977005163 hypothetical protein; Reviewed; Region: PRK12497 693977005164 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 693977005165 Predicted periplasmic protein [Function unknown]; Region: COG3698 693977005166 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 693977005167 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 693977005168 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 693977005169 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 693977005170 NAD binding site [chemical binding]; other site 693977005171 Phe binding site; other site 693977005172 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 693977005173 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 693977005174 putative active site [active] 693977005175 short chain dehydrogenase; Provisional; Region: PRK12827 693977005176 classical (c) SDRs; Region: SDR_c; cd05233 693977005177 NAD(P) binding site [chemical binding]; other site 693977005178 active site 693977005179 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 693977005180 ATP cone domain; Region: ATP-cone; pfam03477 693977005181 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 693977005182 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 693977005183 putative acyl-acceptor binding pocket; other site 693977005184 oxidoreductase; Provisional; Region: PRK06128 693977005185 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 693977005186 NAD binding site [chemical binding]; other site 693977005187 metal binding site [ion binding]; metal-binding site 693977005188 active site 693977005189 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 693977005190 dimer interface [polypeptide binding]; other site 693977005191 [2Fe-2S] cluster binding site [ion binding]; other site 693977005192 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 693977005193 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 693977005194 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 693977005195 Walker A/P-loop; other site 693977005196 ATP binding site [chemical binding]; other site 693977005197 Q-loop/lid; other site 693977005198 ABC transporter signature motif; other site 693977005199 Walker B; other site 693977005200 D-loop; other site 693977005201 H-loop/switch region; other site 693977005202 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 693977005203 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693977005204 ABC-ATPase subunit interface; other site 693977005205 dimer interface [polypeptide binding]; other site 693977005206 putative PBP binding regions; other site 693977005207 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 693977005208 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 693977005209 putative acyl-acceptor binding pocket; other site 693977005210 Exonuclease VII small subunit [DNA replication, recombination, and repair]; Region: XseB; COG1722 693977005211 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 693977005212 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 693977005213 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 693977005214 ATP-grasp domain; Region: ATP-grasp; pfam02222 693977005215 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 693977005216 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 693977005217 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 693977005218 metal binding site [ion binding]; metal-binding site 693977005219 dimer interface [polypeptide binding]; other site 693977005220 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 693977005221 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693977005222 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 693977005223 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 693977005224 FeoA domain; Region: FeoA; pfam04023 693977005225 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 693977005226 active site 693977005227 metal binding site [ion binding]; metal-binding site 693977005228 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 693977005229 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 693977005230 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 693977005231 oligomer interface [polypeptide binding]; other site 693977005232 active site 693977005233 metal binding site [ion binding]; metal-binding site 693977005234 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 693977005235 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 693977005236 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 693977005237 putative [4Fe-4S] binding site [ion binding]; other site 693977005238 putative molybdopterin cofactor binding site [chemical binding]; other site 693977005239 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 693977005240 putative molybdopterin cofactor binding site; other site 693977005241 Uncharacterized conserved protein [Function unknown]; Region: COG2947 693977005242 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 693977005243 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 693977005244 catalytic residue [active] 693977005245 putative FPP diphosphate binding site; other site 693977005246 putative FPP binding hydrophobic cleft; other site 693977005247 dimer interface [polypeptide binding]; other site 693977005248 putative IPP diphosphate binding site; other site 693977005249 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 693977005250 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 693977005251 RNase E interface [polypeptide binding]; other site 693977005252 trimer interface [polypeptide binding]; other site 693977005253 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 693977005254 RNase E interface [polypeptide binding]; other site 693977005255 trimer interface [polypeptide binding]; other site 693977005256 active site 693977005257 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 693977005258 putative nucleic acid binding region [nucleotide binding]; other site 693977005259 G-X-X-G motif; other site 693977005260 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 693977005261 RNA binding site [nucleotide binding]; other site 693977005262 domain interface; other site 693977005263 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 693977005264 catalytic center binding site [active] 693977005265 ATP binding site [chemical binding]; other site 693977005266 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 693977005267 active site 693977005268 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 693977005269 dihydropteroate synthase; Region: DHPS; TIGR01496 693977005270 substrate binding pocket [chemical binding]; other site 693977005271 inhibitor binding site; inhibition site 693977005272 Domain of unknown function (DUF955); Region: DUF955; cl01076 693977005273 Acyl CoA binding protein; Region: ACBP; pfam00887 693977005274 acyl-CoA binding pocket [chemical binding]; other site 693977005275 CoA binding site [chemical binding]; other site 693977005276 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 693977005277 methionine sulfoxide reductase B; Provisional; Region: PRK00222 693977005278 SelR domain; Region: SelR; pfam01641 693977005279 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 693977005280 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 693977005281 catalytic residues [active] 693977005282 Nitronate monooxygenase; Region: NMO; pfam03060 693977005283 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 693977005284 FMN binding site [chemical binding]; other site 693977005285 substrate binding site [chemical binding]; other site 693977005286 putative catalytic residue [active] 693977005287 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 693977005288 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 693977005289 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693977005290 catalytic residue [active] 693977005291 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 693977005292 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693977005293 Coenzyme A binding pocket [chemical binding]; other site 693977005294 FtsH Extracellular; Region: FtsH_ext; pfam06480 693977005295 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 693977005296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693977005297 Walker A motif; other site 693977005298 ATP binding site [chemical binding]; other site 693977005299 Walker B motif; other site 693977005300 arginine finger; other site 693977005301 Peptidase family M41; Region: Peptidase_M41; pfam01434 693977005302 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 693977005303 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 693977005304 nucleotide binding site [chemical binding]; other site 693977005305 NEF interaction site [polypeptide binding]; other site 693977005306 SBD interface [polypeptide binding]; other site 693977005307 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 693977005308 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 693977005309 dimer interface [polypeptide binding]; other site 693977005310 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 693977005311 Uncharacterized conserved protein (DUF2132); Region: DUF2132; cl01894 693977005312 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 693977005313 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 693977005314 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 693977005315 HSP70 interaction site [polypeptide binding]; other site 693977005316 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 693977005317 dimer interface [polypeptide binding]; other site 693977005318 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 693977005319 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 693977005320 NAD binding site [chemical binding]; other site 693977005321 homodimer interface [polypeptide binding]; other site 693977005322 active site 693977005323 substrate binding site [chemical binding]; other site 693977005324 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 693977005325 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 693977005326 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 693977005327 active site 693977005328 putative DNA-binding cleft [nucleotide binding]; other site 693977005329 dimer interface [polypeptide binding]; other site 693977005330 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 693977005331 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 693977005332 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 693977005333 Switch I; other site 693977005334 Switch II; other site 693977005335 cell division topological specificity factor MinE; Region: minE; TIGR01215 693977005336 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 693977005337 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693977005338 active site 693977005339 catalytic tetrad [active] 693977005340 Ferredoxin [Energy production and conversion]; Region: COG1146 693977005341 4Fe-4S binding domain; Region: Fer4; pfam00037 693977005342 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693977005343 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693977005344 dimerization interface [polypeptide binding]; other site 693977005345 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693977005346 dimer interface [polypeptide binding]; other site 693977005347 phosphorylation site [posttranslational modification] 693977005348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693977005349 ATP binding site [chemical binding]; other site 693977005350 Mg2+ binding site [ion binding]; other site 693977005351 G-X-G motif; other site 693977005352 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693977005353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693977005354 active site 693977005355 phosphorylation site [posttranslational modification] 693977005356 intermolecular recognition site; other site 693977005357 dimerization interface [polypeptide binding]; other site 693977005358 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693977005359 DNA binding site [nucleotide binding] 693977005360 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 693977005361 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 693977005362 CMP-binding site; other site 693977005363 The sites determining sugar specificity; other site 693977005364 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 693977005365 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 693977005366 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 693977005367 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 693977005368 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693977005369 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 693977005370 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693977005371 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 693977005372 Phosphotransferase enzyme family; Region: APH; pfam01636 693977005373 active site 693977005374 ATP binding site [chemical binding]; other site 693977005375 antibiotic binding site [chemical binding]; other site 693977005376 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 693977005377 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 693977005378 minor groove reading motif; other site 693977005379 helix-hairpin-helix signature motif; other site 693977005380 substrate binding pocket [chemical binding]; other site 693977005381 active site 693977005382 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 693977005383 Cupin domain; Region: Cupin_2; cl17218 693977005384 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 693977005385 putative active site [active] 693977005386 putative substrate binding site [chemical binding]; other site 693977005387 ATP binding site [chemical binding]; other site 693977005388 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 693977005389 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 693977005390 active site 693977005391 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 693977005392 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693977005393 NAD(P) binding site [chemical binding]; other site 693977005394 active site 693977005395 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693977005396 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693977005397 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 693977005398 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 693977005399 active site 693977005400 interdomain interaction site; other site 693977005401 putative metal-binding site [ion binding]; other site 693977005402 nucleotide binding site [chemical binding]; other site 693977005403 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 693977005404 domain I; other site 693977005405 phosphate binding site [ion binding]; other site 693977005406 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 693977005407 domain II; other site 693977005408 domain III; other site 693977005409 nucleotide binding site [chemical binding]; other site 693977005410 DNA binding groove [nucleotide binding] 693977005411 catalytic site [active] 693977005412 domain IV; other site 693977005413 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 693977005414 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 693977005415 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 693977005416 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 693977005417 putative active site [active] 693977005418 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 693977005419 MviN-like protein; Region: MVIN; pfam03023 693977005420 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 693977005421 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 693977005422 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693977005423 FeS/SAM binding site; other site 693977005424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693977005425 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693977005426 putative substrate translocation pore; other site 693977005427 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 693977005428 dimer interface [polypeptide binding]; other site 693977005429 FMN binding site [chemical binding]; other site 693977005430 Predicted transcriptional regulators [Transcription]; Region: COG1733 693977005431 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693977005432 putative DNA binding site [nucleotide binding]; other site 693977005433 putative Zn2+ binding site [ion binding]; other site 693977005434 Cupin domain; Region: Cupin_2; cl17218 693977005435 Cytochrome P450; Region: p450; cl12078 693977005436 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 693977005437 AAA ATPase domain; Region: AAA_16; pfam13191 693977005438 glycine dehydrogenase; Provisional; Region: PRK05367 693977005439 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 693977005440 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693977005441 tetramer interface [polypeptide binding]; other site 693977005442 catalytic residue [active] 693977005443 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 693977005444 tetramer interface [polypeptide binding]; other site 693977005445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693977005446 catalytic residue [active] 693977005447 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 693977005448 lipoyl attachment site [posttranslational modification]; other site 693977005449 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 693977005450 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 693977005451 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 693977005452 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 693977005453 intracellular protease, PfpI family; Region: PfpI; TIGR01382 693977005454 proposed catalytic triad [active] 693977005455 conserved cys residue [active] 693977005456 DNA primase, catalytic core; Region: dnaG; TIGR01391 693977005457 CHC2 zinc finger; Region: zf-CHC2; pfam01807 693977005458 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 693977005459 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 693977005460 active site 693977005461 metal binding site [ion binding]; metal-binding site 693977005462 interdomain interaction site; other site 693977005463 glutamate racemase; Provisional; Region: PRK00865 693977005464 Methyltransferase domain; Region: Methyltransf_23; pfam13489 693977005465 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693977005466 S-adenosylmethionine binding site [chemical binding]; other site 693977005467 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 693977005468 putative active site [active] 693977005469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693977005470 S-adenosylmethionine binding site [chemical binding]; other site 693977005471 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 693977005472 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 693977005473 DNA protecting protein DprA; Region: dprA; TIGR00732 693977005474 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693977005475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693977005476 ATP binding site [chemical binding]; other site 693977005477 G-X-G motif; other site 693977005478 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693977005479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693977005480 active site 693977005481 phosphorylation site [posttranslational modification] 693977005482 intermolecular recognition site; other site 693977005483 dimerization interface [polypeptide binding]; other site 693977005484 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693977005485 DNA binding site [nucleotide binding] 693977005486 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 693977005487 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693977005488 E3 interaction surface; other site 693977005489 lipoyl attachment site [posttranslational modification]; other site 693977005490 e3 binding domain; Region: E3_binding; pfam02817 693977005491 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 693977005492 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 693977005493 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 693977005494 alpha subunit interface [polypeptide binding]; other site 693977005495 TPP binding site [chemical binding]; other site 693977005496 heterodimer interface [polypeptide binding]; other site 693977005497 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 693977005498 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 693977005499 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 693977005500 tetramer interface [polypeptide binding]; other site 693977005501 TPP-binding site [chemical binding]; other site 693977005502 heterodimer interface [polypeptide binding]; other site 693977005503 phosphorylation loop region [posttranslational modification] 693977005504 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 693977005505 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 693977005506 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 693977005507 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 693977005508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693977005509 S-adenosylmethionine binding site [chemical binding]; other site 693977005510 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 693977005511 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693977005512 P-loop; other site 693977005513 Magnesium ion binding site [ion binding]; other site 693977005514 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693977005515 Magnesium ion binding site [ion binding]; other site 693977005516 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 693977005517 ParB-like nuclease domain; Region: ParB; smart00470 693977005518 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 693977005519 Ligand Binding Site [chemical binding]; other site 693977005520 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 693977005521 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 693977005522 NAD(P) binding site [chemical binding]; other site 693977005523 LDH/MDH dimer interface [polypeptide binding]; other site 693977005524 substrate binding site [chemical binding]; other site 693977005525 OstA-like protein; Region: OstA; cl00844 693977005526 OstA-like protein; Region: OstA; cl00844 693977005527 OstA-like protein; Region: OstA; cl00844 693977005528 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 693977005529 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 693977005530 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 693977005531 Walker A/P-loop; other site 693977005532 ATP binding site [chemical binding]; other site 693977005533 Q-loop/lid; other site 693977005534 ABC transporter signature motif; other site 693977005535 Walker B; other site 693977005536 D-loop; other site 693977005537 H-loop/switch region; other site 693977005538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 693977005539 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693977005540 ABC-ATPase subunit interface; other site 693977005541 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 693977005542 Helix-turn-helix domain; Region: HTH_17; pfam12728 693977005543 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 693977005544 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 693977005545 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 693977005546 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 693977005547 oligomer interface [polypeptide binding]; other site 693977005548 metal binding site [ion binding]; metal-binding site 693977005549 metal binding site [ion binding]; metal-binding site 693977005550 putative Cl binding site [ion binding]; other site 693977005551 aspartate ring; other site 693977005552 basic sphincter; other site 693977005553 hydrophobic gate; other site 693977005554 periplasmic entrance; other site 693977005555 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 693977005556 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 693977005557 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 693977005558 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 693977005559 putative Zn2+ binding site [ion binding]; other site 693977005560 putative DNA binding site [nucleotide binding]; other site 693977005561 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 693977005562 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 693977005563 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693977005564 S-adenosylmethionine binding site [chemical binding]; other site 693977005565 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 693977005566 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 693977005567 substrate-cofactor binding pocket; other site 693977005568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693977005569 catalytic residue [active] 693977005570 Helix-turn-helix domain; Region: HTH_17; pfam12728 693977005571 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693977005572 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 693977005573 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693977005574 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693977005575 homodimer interface [polypeptide binding]; other site 693977005576 catalytic residue [active] 693977005577 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 693977005578 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 693977005579 Walker A/P-loop; other site 693977005580 ATP binding site [chemical binding]; other site 693977005581 Q-loop/lid; other site 693977005582 ABC transporter signature motif; other site 693977005583 Walker B; other site 693977005584 D-loop; other site 693977005585 H-loop/switch region; other site 693977005586 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 693977005587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693977005588 dimer interface [polypeptide binding]; other site 693977005589 conserved gate region; other site 693977005590 putative PBP binding loops; other site 693977005591 ABC-ATPase subunit interface; other site 693977005592 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693977005593 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693977005594 substrate binding pocket [chemical binding]; other site 693977005595 membrane-bound complex binding site; other site 693977005596 hinge residues; other site 693977005597 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 693977005598 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 693977005599 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 693977005600 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693977005601 Coenzyme A binding pocket [chemical binding]; other site 693977005602 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 693977005603 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 693977005604 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 693977005605 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 693977005606 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 693977005607 active site 693977005608 substrate binding site [chemical binding]; other site 693977005609 coenzyme B12 binding site [chemical binding]; other site 693977005610 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 693977005611 B12 binding site [chemical binding]; other site 693977005612 cobalt ligand [ion binding]; other site 693977005613 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 693977005614 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 693977005615 active site 693977005616 dimer interface [polypeptide binding]; other site 693977005617 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 693977005618 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 693977005619 active site 693977005620 FMN binding site [chemical binding]; other site 693977005621 substrate binding site [chemical binding]; other site 693977005622 3Fe-4S cluster binding site [ion binding]; other site 693977005623 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 693977005624 domain interface; other site 693977005625 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 693977005626 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 693977005627 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 693977005628 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 693977005629 substrate binding site [chemical binding]; other site 693977005630 hexamer interface [polypeptide binding]; other site 693977005631 metal binding site [ion binding]; metal-binding site 693977005632 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 693977005633 2-phosphosulfolactate phosphatase; Provisional; Region: PRK14100 693977005634 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 693977005635 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 693977005636 dimer interface [polypeptide binding]; other site 693977005637 active site 693977005638 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693977005639 catalytic residues [active] 693977005640 substrate binding site [chemical binding]; other site 693977005641 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 693977005642 DNA binding site [nucleotide binding] 693977005643 active site 693977005644 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 693977005645 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 693977005646 intersubunit interface [polypeptide binding]; other site 693977005647 active site 693977005648 zinc binding site [ion binding]; other site 693977005649 Na+ binding site [ion binding]; other site 693977005650 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 693977005651 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 693977005652 active site 693977005653 metal binding site [ion binding]; metal-binding site 693977005654 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 693977005655 putative active site [active] 693977005656 putative metal binding site [ion binding]; other site 693977005657 glycogen synthase; Provisional; Region: glgA; PRK00654 693977005658 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 693977005659 ADP-binding pocket [chemical binding]; other site 693977005660 homodimer interface [polypeptide binding]; other site 693977005661 Methyltransferase domain; Region: Methyltransf_26; pfam13659 693977005662 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 693977005663 DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864 693977005664 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 693977005665 active site 693977005666 substrate binding site [chemical binding]; other site 693977005667 Mg2+ binding site [ion binding]; other site 693977005668 Excalibur calcium-binding domain; Region: Excalibur; smart00894 693977005669 CRISPR/Cas system-associated protein Csx16; Region: Csx16_III-U; cl09866 693977005670 Domain of unknown function (DUF4326); Region: DUF4326; pfam14216 693977005671 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 693977005672 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 693977005673 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 693977005674 dimer interface [polypeptide binding]; other site 693977005675 ssDNA binding site [nucleotide binding]; other site 693977005676 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693977005677 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 693977005678 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 693977005679 dimer interface [polypeptide binding]; other site 693977005680 ssDNA binding site [nucleotide binding]; other site 693977005681 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693977005682 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 693977005683 dimer interface [polypeptide binding]; other site 693977005684 ssDNA binding site [nucleotide binding]; other site 693977005685 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693977005686 RES domain; Region: RES; pfam08808 693977005687 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 693977005688 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693977005689 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693977005690 catalytic residue [active] 693977005691 N-terminal catalytic domain of GIY-YIG intron endonuclease I-TevI, I-BmoI, I-BanI, I-BthII and similar proteins; Region: GIY-YIG_HE_I-TevI_like; cd10437 693977005692 GIY-YIG motif/motif A; other site 693977005693 putative active site [active] 693977005694 catalytic site [active] 693977005695 putative metal binding site [ion binding]; other site 693977005696 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 693977005697 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 693977005698 ATP binding site [chemical binding]; other site 693977005699 putative Mg++ binding site [ion binding]; other site 693977005700 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693977005701 nucleotide binding region [chemical binding]; other site 693977005702 ATP-binding site [chemical binding]; other site 693977005703 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 693977005704 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 693977005705 dimer interface [polypeptide binding]; other site 693977005706 ssDNA binding site [nucleotide binding]; other site 693977005707 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693977005708 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 693977005709 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 693977005710 dimer interface [polypeptide binding]; other site 693977005711 ssDNA binding site [nucleotide binding]; other site 693977005712 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693977005713 CheD chemotactic sensory transduction; Region: CheD; cl00810 693977005714 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 693977005715 RNA/DNA hybrid binding site [nucleotide binding]; other site 693977005716 active site 693977005717 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 693977005718 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 693977005719 dimer interface [polypeptide binding]; other site 693977005720 ssDNA binding site [nucleotide binding]; other site 693977005721 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693977005722 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 693977005723 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 693977005724 dimer interface [polypeptide binding]; other site 693977005725 ssDNA binding site [nucleotide binding]; other site 693977005726 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693977005727 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 693977005728 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693977005729 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693977005730 catalytic residue [active] 693977005731 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693977005732 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 693977005733 putative active site [active] 693977005734 ParB-like nuclease domain; Region: ParB; smart00470 693977005735 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 693977005736 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693977005737 P-loop; other site 693977005738 Magnesium ion binding site [ion binding]; other site 693977005739 ParB-like nuclease domain; Region: ParB; smart00470 693977005740 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 693977005741 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 693977005742 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 693977005743 metal ion-dependent adhesion site (MIDAS); other site 693977005744 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 693977005745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693977005746 S-adenosylmethionine binding site [chemical binding]; other site 693977005747 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693977005748 nucleotide binding region [chemical binding]; other site 693977005749 ATP-binding site [chemical binding]; other site 693977005750 DdrB-like protein; Region: DdrB; pfam12747 693977005751 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 693977005752 AAA domain; Region: AAA_30; pfam13604 693977005753 Family description; Region: UvrD_C_2; pfam13538 693977005754 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 693977005755 DNA topoisomerase I, bacterial; Region: topA_bact; TIGR01051 693977005756 active site 693977005757 interdomain interaction site; other site 693977005758 putative metal-binding site [ion binding]; other site 693977005759 nucleotide binding site [chemical binding]; other site 693977005760 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 693977005761 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 693977005762 domain II; other site 693977005763 domain III; other site 693977005764 nucleotide binding site [chemical binding]; other site 693977005765 DNA binding groove [nucleotide binding] 693977005766 catalytic site [active] 693977005767 domain IV; other site 693977005768 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 693977005769 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693977005770 Walker A/P-loop; other site 693977005771 ATP binding site [chemical binding]; other site 693977005772 PRTRC system protein E; Region: PRTRC_E; TIGR03741 693977005773 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 693977005774 Prokaryotic Ubiquitin; Region: Prok_Ub; cl14020 693977005775 Prokaryotic E2 family D; Region: Prok-E2_D; cl14019 693977005776 PRTRC system ThiF family protein; Region: PRTRC_ThiF; TIGR03736 693977005777 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 693977005778 ATP binding site [chemical binding]; other site 693977005779 substrate interface [chemical binding]; other site 693977005780 Prokaryotic E2 family D; Region: Prok-E2_D; cl14019 693977005781 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 693977005782 ATP binding site [chemical binding]; other site 693977005783 substrate interface [chemical binding]; other site 693977005784 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 693977005785 IHF - DNA interface [nucleotide binding]; other site 693977005786 IHF dimer interface [polypeptide binding]; other site 693977005787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 693977005788 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 693977005789 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 693977005790 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 693977005791 Probable transposase; Region: OrfB_IS605; pfam01385 693977005792 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 693977005793 Replication initiator protein A; Region: RPA; cl17860 693977005794 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 693977005795 photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060 693977005796 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 693977005797 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 693977005798 Family description; Region: UvrD_C_2; pfam13538 693977005799 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 693977005800 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 693977005801 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 693977005802 RES domain; Region: RES; smart00953 693977005803 Thioredoxin; Region: Thioredoxin_4; pfam13462 693977005804 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 693977005805 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 693977005806 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 693977005807 metal-binding site [ion binding] 693977005808 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 693977005809 Soluble P-type ATPase [General function prediction only]; Region: COG4087 693977005810 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 693977005811 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 693977005812 catalytic residues [active] 693977005813 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 693977005814 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 693977005815 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 693977005816 Cu(I) binding site [ion binding]; other site 693977005817 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693977005818 dimerization interface [polypeptide binding]; other site 693977005819 putative DNA binding site [nucleotide binding]; other site 693977005820 putative Zn2+ binding site [ion binding]; other site 693977005821 hypothetical protein; Provisional; Region: PRK02237 693977005822 Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; cl01558 693977005823 DDE superfamily endonuclease; Region: DDE_5; cl17874 693977005824 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693977005825 Protein of unknown function (DUF3419); Region: DUF3419; cl15422 693977005826 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 693977005827 Protein of unknown function DUF91; Region: DUF91; cl00709 693977005828 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 693977005829 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693977005830 Beta-Casp domain; Region: Beta-Casp; smart01027 693977005831 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 693977005832 Predicted transcriptional regulator [Transcription]; Region: COG4189 693977005833 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; cl01017 693977005834 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 693977005835 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 693977005836 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693977005837 Walker A motif; other site 693977005838 ATP binding site [chemical binding]; other site 693977005839 Walker B motif; other site 693977005840 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 693977005841 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693977005842 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693977005843 Walker A motif; other site 693977005844 Walker A/P-loop; other site 693977005845 ATP binding site [chemical binding]; other site 693977005846 ATP binding site [chemical binding]; other site 693977005847 Walker B motif; other site 693977005848 Pilus assembly protein, PilO; Region: PilO; cl01234 693977005849 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 693977005850 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 693977005851 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 693977005852 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 693977005853 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 693977005854 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 693977005855 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 693977005856 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 693977005857 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 693977005858 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 693977005859 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 693977005860 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 693977005861 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693977005862 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693977005863 Coenzyme A binding pocket [chemical binding]; other site 693977005864 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 693977005865 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 693977005866 putative active site [active] 693977005867 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 693977005868 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 693977005869 polymerase nucleotide-binding site; other site 693977005870 DNA-binding residues [nucleotide binding]; DNA binding site 693977005871 nucleotide binding site [chemical binding]; other site 693977005872 primase nucleotide-binding site [nucleotide binding]; other site 693977005873 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 693977005874 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 693977005875 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693977005876 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 693977005877 AAA-like domain; Region: AAA_10; pfam12846 693977005878 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 693977005879 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693977005880 Walker A motif; other site 693977005881 ATP binding site [chemical binding]; other site 693977005882 Walker B motif; other site 693977005883 DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864 693977005884 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 693977005885 active site 693977005886 substrate binding site [chemical binding]; other site 693977005887 Mg2+ binding site [ion binding]; other site 693977005888 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 693977005889 AAA domain; Region: AAA_30; pfam13604 693977005890 Family description; Region: UvrD_C_2; pfam13538 693977005891 Helix-turn-helix domain; Region: HTH_17; pfam12728 693977005892 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 693977005893 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 693977005894 active site 693977005895 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 693977005896 PemK-like protein; Region: PemK; cl00995 693977005897 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 693977005898 putative active site [active] 693977005899 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 693977005900 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 693977005901 RES domain; Region: RES; pfam08808 693977005902 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 693977005903 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693977005904 dimerization interface [polypeptide binding]; other site 693977005905 putative DNA binding site [nucleotide binding]; other site 693977005906 putative Zn2+ binding site [ion binding]; other site 693977005907 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 693977005908 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 693977005909 Walker A/P-loop; other site 693977005910 ATP binding site [chemical binding]; other site 693977005911 Q-loop/lid; other site 693977005912 ABC transporter signature motif; other site 693977005913 Walker B; other site 693977005914 D-loop; other site 693977005915 H-loop/switch region; other site 693977005916 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 693977005917 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 693977005918 DNA binding residues [nucleotide binding] 693977005919 putative dimer interface [polypeptide binding]; other site 693977005920 Integrase core domain; Region: rve; pfam00665 693977005921 Integrase core domain; Region: rve_3; pfam13683 693977005922 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693977005923 Transposase; Region: HTH_Tnp_1; pfam01527 693977005924 Nuclease-related domain; Region: NERD; pfam08378 693977005925 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 693977005926 Family description; Region: UvrD_C_2; pfam13538 693977005927 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693977005928 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 693977005929 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 693977005930 active site 693977005931 Zn binding site [ion binding]; other site 693977005932 DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864 693977005933 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 693977005934 active site 693977005935 substrate binding site [chemical binding]; other site 693977005936 Mg2+ binding site [ion binding]; other site 693977005937 AAA domain; Region: AAA_30; pfam13604 693977005938 Family description; Region: UvrD_C_2; pfam13538 693977005939 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 693977005940 multiple promoter invertase; Provisional; Region: mpi; PRK13413 693977005941 catalytic residues [active] 693977005942 catalytic nucleophile [active] 693977005943 Presynaptic Site I dimer interface [polypeptide binding]; other site 693977005944 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 693977005945 Synaptic Flat tetramer interface [polypeptide binding]; other site 693977005946 Synaptic Site I dimer interface [polypeptide binding]; other site 693977005947 DNA binding site [nucleotide binding] 693977005948 Homeodomain-like domain; Region: HTH_23; pfam13384 693977005949 Predicted transcriptional regulator [Transcription]; Region: COG1959 693977005950 Transcriptional regulator; Region: Rrf2; pfam02082 693977005951 short chain dehydrogenase; Provisional; Region: PRK12747 693977005952 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693977005953 NAD(P) binding site [chemical binding]; other site 693977005954 active site 693977005955 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 693977005956 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 693977005957 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 693977005958 DDE superfamily endonuclease; Region: DDE_3; pfam13358 693977005959 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 693977005960 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 693977005961 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693977005962 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 693977005963 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693977005964 Integrase core domain; Region: rve; pfam00665 693977005965 Integrase core domain; Region: rve_3; pfam13683 693977005966 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693977005967 Transposase; Region: HTH_Tnp_1; pfam01527 693977005968 Domain of unknown function (DUF305); Region: DUF305; pfam03713 693977005969 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693977005970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693977005971 active site 693977005972 phosphorylation site [posttranslational modification] 693977005973 intermolecular recognition site; other site 693977005974 dimerization interface [polypeptide binding]; other site 693977005975 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693977005976 DNA binding site [nucleotide binding] 693977005977 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693977005978 dimerization interface [polypeptide binding]; other site 693977005979 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693977005980 dimer interface [polypeptide binding]; other site 693977005981 phosphorylation site [posttranslational modification] 693977005982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693977005983 ATP binding site [chemical binding]; other site 693977005984 Mg2+ binding site [ion binding]; other site 693977005985 G-X-G motif; other site 693977005986 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 693977005987 dimerization interface [polypeptide binding]; other site 693977005988 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 693977005989 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 693977005990 Integrase core domain; Region: rve; pfam00665 693977005991 Domain of unknown function (DUF305); Region: DUF305; pfam03713 693977005992 Replication initiator protein A; Region: RPA; cl17860 693977005993 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 693977005994 ParB-like nuclease domain; Region: ParBc; pfam02195 693977005995 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 693977005996 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693977005997 P-loop; other site 693977005998 Magnesium ion binding site [ion binding]; other site 693977005999 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693977006000 Magnesium ion binding site [ion binding]; other site 693977006001 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 693977006002 Protein of unknown function (DUF790); Region: DUF790; pfam05626 693977006003 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 693977006004 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693977006005 ATP binding site [chemical binding]; other site 693977006006 putative Mg++ binding site [ion binding]; other site 693977006007 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693977006008 nucleotide binding region [chemical binding]; other site 693977006009 ATP-binding site [chemical binding]; other site 693977006010 DDE superfamily endonuclease; Region: DDE_3; pfam13358 693977006011 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 693977006012 Domain of unknown function (DUF305); Region: DUF305; pfam03713 693977006013 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693977006014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693977006015 active site 693977006016 phosphorylation site [posttranslational modification] 693977006017 intermolecular recognition site; other site 693977006018 dimerization interface [polypeptide binding]; other site 693977006019 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693977006020 DNA binding site [nucleotide binding] 693977006021 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693977006022 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693977006023 dimerization interface [polypeptide binding]; other site 693977006024 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693977006025 dimer interface [polypeptide binding]; other site 693977006026 phosphorylation site [posttranslational modification] 693977006027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693977006028 ATP binding site [chemical binding]; other site 693977006029 Mg2+ binding site [ion binding]; other site 693977006030 G-X-G motif; other site 693977006031 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 693977006032 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 693977006033 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 693977006034 Soluble P-type ATPase [General function prediction only]; Region: COG4087 693977006035 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 693977006036 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 693977006037 Homeodomain-like domain; Region: HTH_23; pfam13384 693977006038 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693977006039 SEFIR domain; Region: SEFIR; pfam08357 693977006040 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 693977006041 metal binding site [ion binding]; metal-binding site 693977006042 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 693977006043 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 693977006044 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693977006045 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693977006046 non-specific DNA binding site [nucleotide binding]; other site 693977006047 salt bridge; other site 693977006048 sequence-specific DNA binding site [nucleotide binding]; other site 693977006049 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 693977006050 Helix-turn-helix domain; Region: HTH_36; pfam13730 693977006051 LexA repressor; Validated; Region: PRK00215 693977006052 AntA/AntB antirepressor; Region: AntA; pfam08346 693977006053 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 693977006054 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 693977006055 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 693977006056 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693977006057 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 693977006058 catalytic residues [active] 693977006059 catalytic nucleophile [active] 693977006060 Presynaptic Site I dimer interface [polypeptide binding]; other site 693977006061 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 693977006062 Synaptic Flat tetramer interface [polypeptide binding]; other site 693977006063 Synaptic Site I dimer interface [polypeptide binding]; other site 693977006064 DNA binding site [nucleotide binding] 693977006065 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 693977006066 DNA-binding interface [nucleotide binding]; DNA binding site 693977006067 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693977006068 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 693977006069 CAAX protease self-immunity; Region: Abi; pfam02517 693977006070 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 693977006071 RibD C-terminal domain; Region: RibD_C; cl17279 693977006072 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693977006073 Transposase; Region: HTH_Tnp_1; pfam01527 693977006074 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693977006075 HTH-like domain; Region: HTH_21; pfam13276 693977006076 Integrase core domain; Region: rve; pfam00665 693977006077 Integrase core domain; Region: rve_2; pfam13333 693977006078 Transposase; Region: HTH_Tnp_1; pfam01527 693977006079 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693977006080 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 693977006081 catalytic residues [active] 693977006082 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 693977006083 putative homodimer interface [polypeptide binding]; other site 693977006084 putative homotetramer interface [polypeptide binding]; other site 693977006085 allosteric switch controlling residues; other site 693977006086 putative metal binding site [ion binding]; other site 693977006087 putative homodimer-homodimer interface [polypeptide binding]; other site 693977006088 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693977006089 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 693977006090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693977006091 dimer interface [polypeptide binding]; other site 693977006092 conserved gate region; other site 693977006093 putative PBP binding loops; other site 693977006094 ABC-ATPase subunit interface; other site 693977006095 NMT1-like family; Region: NMT1_2; pfam13379 693977006096 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 693977006097 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 693977006098 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 693977006099 Walker A/P-loop; other site 693977006100 ATP binding site [chemical binding]; other site 693977006101 Q-loop/lid; other site 693977006102 ABC transporter signature motif; other site 693977006103 Walker B; other site 693977006104 D-loop; other site 693977006105 H-loop/switch region; other site 693977006106 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 693977006107 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 693977006108 active site 693977006109 Uncharacterized conserved protein [Function unknown]; Region: COG2128 693977006110 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 693977006111 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 693977006112 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693977006113 Walker A/P-loop; other site 693977006114 ATP binding site [chemical binding]; other site 693977006115 Q-loop/lid; other site 693977006116 ABC transporter signature motif; other site 693977006117 Walker B; other site 693977006118 D-loop; other site 693977006119 H-loop/switch region; other site 693977006120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693977006121 dimer interface [polypeptide binding]; other site 693977006122 conserved gate region; other site 693977006123 ABC-ATPase subunit interface; other site 693977006124 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 693977006125 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 693977006126 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 693977006127 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 693977006128 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 693977006129 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 693977006130 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 693977006131 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693977006132 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693977006133 metal binding site [ion binding]; metal-binding site 693977006134 active site 693977006135 I-site; other site 693977006136 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 693977006137 Domain of unknown function DUF21; Region: DUF21; pfam01595 693977006138 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 693977006139 Transporter associated domain; Region: CorC_HlyC; smart01091 693977006140 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 693977006141 Domain of unknown function DUF21; Region: DUF21; pfam01595 693977006142 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 693977006143 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 693977006144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 693977006145 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 693977006146 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 693977006147 tetramer interface [polypeptide binding]; other site 693977006148 heme binding pocket [chemical binding]; other site 693977006149 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693977006150 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 693977006151 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693977006152 P-loop; other site 693977006153 Magnesium ion binding site [ion binding]; other site 693977006154 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693977006155 Magnesium ion binding site [ion binding]; other site 693977006156 ParB-like nuclease domain; Region: ParB; smart00470 693977006157 Replication initiator protein A; Region: RPA; cl17860 693977006158 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 693977006159 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 693977006160 Cysteine-rich domain; Region: CCG; pfam02754 693977006161 Cysteine-rich domain; Region: CCG; pfam02754 693977006162 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 693977006163 FAD binding domain; Region: FAD_binding_4; pfam01565 693977006164 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 693977006165 Yip1 domain; Region: Yip1; cl17815 693977006166 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 693977006167 catalytic triad [active] 693977006168 conserved cis-peptide bond; other site 693977006169 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 693977006170 multidrug efflux protein NorA; Provisional; Region: PRK00187 693977006171 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 693977006172 cation binding site [ion binding]; other site 693977006173 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 693977006174 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 693977006175 metal-binding site [ion binding] 693977006176 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 693977006177 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693977006178 motif II; other site 693977006179 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 693977006180 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 693977006181 metal-binding site [ion binding] 693977006182 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 693977006183 metal-binding site [ion binding] 693977006184 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 693977006185 putative homodimer interface [polypeptide binding]; other site 693977006186 putative homotetramer interface [polypeptide binding]; other site 693977006187 allosteric switch controlling residues; other site 693977006188 putative metal binding site [ion binding]; other site 693977006189 putative homodimer-homodimer interface [polypeptide binding]; other site 693977006190 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 693977006191 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 693977006192 hydroperoxidase II; Provisional; Region: katE; PRK11249 693977006193 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 693977006194 tetramer interface [polypeptide binding]; other site 693977006195 heme binding pocket [chemical binding]; other site 693977006196 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 693977006197 domain interactions; other site 693977006198 Chain length determinant protein; Region: Wzz; cl15801 693977006199 AAA domain; Region: AAA_31; pfam13614 693977006200 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693977006201 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693977006202 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 693977006203 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 693977006204 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693977006205 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 693977006206 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 693977006207 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 693977006208 NAD(P) binding site [chemical binding]; other site 693977006209 homodimer interface [polypeptide binding]; other site 693977006210 substrate binding site [chemical binding]; other site 693977006211 active site 693977006212 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 693977006213 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693977006214 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 693977006215 NAD(P) binding site [chemical binding]; other site 693977006216 active site 693977006217 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 693977006218 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 693977006219 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 693977006220 active site 693977006221 homodimer interface [polypeptide binding]; other site 693977006222 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 693977006223 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 693977006224 Bacterial sugar transferase; Region: Bac_transf; pfam02397 693977006225 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 693977006226 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693977006227 Coenzyme A binding pocket [chemical binding]; other site 693977006228 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 693977006229 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 693977006230 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693977006231 catalytic residue [active] 693977006232 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 693977006233 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 693977006234 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 693977006235 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 693977006236 inhibitor-cofactor binding pocket; inhibition site 693977006237 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693977006238 catalytic residue [active] 693977006239 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 693977006240 CoA binding domain; Region: CoA_binding; smart00881 693977006241 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693977006242 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 693977006243 NAD(P) binding site [chemical binding]; other site 693977006244 homodimer interface [polypeptide binding]; other site 693977006245 substrate binding site [chemical binding]; other site 693977006246 active site 693977006247 DNA photolyase; Region: DNA_photolyase; pfam00875 693977006248 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 693977006249 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 693977006250 ligand binding site [chemical binding]; other site 693977006251 active site 693977006252 UGI interface [polypeptide binding]; other site 693977006253 catalytic site [active] 693977006254 MarR family; Region: MarR_2; cl17246 693977006255 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 693977006256 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 693977006257 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 693977006258 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 693977006259 dimer interface [polypeptide binding]; other site 693977006260 substrate binding site [chemical binding]; other site 693977006261 ATP binding site [chemical binding]; other site 693977006262 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 693977006263 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 693977006264 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 693977006265 ThiS interaction site; other site 693977006266 putative active site [active] 693977006267 tetramer interface [polypeptide binding]; other site 693977006268 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 693977006269 thiS-thiF/thiG interaction site; other site 693977006270 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 693977006271 thiamine phosphate binding site [chemical binding]; other site 693977006272 active site 693977006273 pyrophosphate binding site [ion binding]; other site 693977006274 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 693977006275 ThiC-associated domain; Region: ThiC-associated; pfam13667 693977006276 ThiC family; Region: ThiC; pfam01964 693977006277 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 693977006278 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 693977006279 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 693977006280 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 693977006281 substrate binding site [chemical binding]; other site 693977006282 glutamase interaction surface [polypeptide binding]; other site 693977006283 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 693977006284 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 693977006285 catalytic residues [active] 693977006286 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 693977006287 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 693977006288 putative active site [active] 693977006289 oxyanion strand; other site 693977006290 catalytic triad [active] 693977006291 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 693977006292 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693977006293 active site 693977006294 motif I; other site 693977006295 motif II; other site 693977006296 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 693977006297 4-fold oligomerization interface [polypeptide binding]; other site 693977006298 putative active site pocket [active] 693977006299 metal binding residues [ion binding]; metal-binding site 693977006300 3-fold/trimer interface [polypeptide binding]; other site 693977006301 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 693977006302 histidinol dehydrogenase; Region: hisD; TIGR00069 693977006303 NAD binding site [chemical binding]; other site 693977006304 dimerization interface [polypeptide binding]; other site 693977006305 product binding site; other site 693977006306 substrate binding site [chemical binding]; other site 693977006307 zinc binding site [ion binding]; other site 693977006308 catalytic residues [active] 693977006309 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 693977006310 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 693977006311 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 693977006312 ornithine carbamoyltransferase; Validated; Region: PRK02102 693977006313 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 693977006314 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 693977006315 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 693977006316 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 693977006317 active site 693977006318 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693977006319 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693977006320 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693977006321 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 693977006322 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 693977006323 N-acetyl-D-glucosamine binding site [chemical binding]; other site 693977006324 catalytic residue [active] 693977006325 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 693977006326 MoaE interaction surface [polypeptide binding]; other site 693977006327 MoeB interaction surface [polypeptide binding]; other site 693977006328 thiocarboxylated glycine; other site 693977006329 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 693977006330 MoaE homodimer interface [polypeptide binding]; other site 693977006331 MoaD interaction [polypeptide binding]; other site 693977006332 active site residues [active] 693977006333 Sodium Bile acid symporter family; Region: SBF; cl17470 693977006334 bile acid transporter; Region: bass; TIGR00841 693977006335 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 693977006336 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 693977006337 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 693977006338 active site turn [active] 693977006339 phosphorylation site [posttranslational modification] 693977006340 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 693977006341 HPr interaction site; other site 693977006342 glycerol kinase (GK) interaction site [polypeptide binding]; other site 693977006343 active site 693977006344 phosphorylation site [posttranslational modification] 693977006345 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 693977006346 dimerization domain swap beta strand [polypeptide binding]; other site 693977006347 regulatory protein interface [polypeptide binding]; other site 693977006348 active site 693977006349 regulatory phosphorylation site [posttranslational modification]; other site 693977006350 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 693977006351 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 693977006352 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 693977006353 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 693977006354 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 693977006355 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693977006356 active site 693977006357 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 693977006358 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 693977006359 dimer interface [polypeptide binding]; other site 693977006360 active site 693977006361 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 693977006362 dimer interface [polypeptide binding]; other site 693977006363 active site 693977006364 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 693977006365 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 693977006366 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 693977006367 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 693977006368 active site 693977006369 NTP binding site [chemical binding]; other site 693977006370 metal binding triad [ion binding]; metal-binding site 693977006371 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 693977006372 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693977006373 Zn2+ binding site [ion binding]; other site 693977006374 Mg2+ binding site [ion binding]; other site 693977006375 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 693977006376 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693977006377 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 693977006378 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 693977006379 dimanganese center [ion binding]; other site 693977006380 Bacterial SH3 domain; Region: SH3_3; pfam08239 693977006381 Right handed beta helix region; Region: Beta_helix; pfam13229 693977006382 Right handed beta helix region; Region: Beta_helix; pfam13229 693977006383 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 693977006384 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693977006385 active site 693977006386 Int/Topo IB signature motif; other site 693977006387 DNA binding site [nucleotide binding] 693977006388 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 693977006389 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 693977006390 substrate binding site [chemical binding]; other site 693977006391 active site 693977006392 catalytic residues [active] 693977006393 heterodimer interface [polypeptide binding]; other site 693977006394 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 693977006395 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 693977006396 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693977006397 catalytic residue [active] 693977006398 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 693977006399 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 693977006400 active site 693977006401 ribulose/triose binding site [chemical binding]; other site 693977006402 phosphate binding site [ion binding]; other site 693977006403 substrate (anthranilate) binding pocket [chemical binding]; other site 693977006404 product (indole) binding pocket [chemical binding]; other site 693977006405 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 693977006406 active site 693977006407 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 693977006408 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 693977006409 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 693977006410 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 693977006411 Glutamine amidotransferase class-I; Region: GATase; pfam00117 693977006412 glutamine binding [chemical binding]; other site 693977006413 catalytic triad [active] 693977006414 anthranilate synthase component I; Provisional; Region: PRK13564 693977006415 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 693977006416 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 693977006417 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 693977006418 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 693977006419 putative active site [active] 693977006420 putative metal binding site [ion binding]; other site 693977006421 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 693977006422 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 693977006423 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693977006424 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577 693977006425 putative active site [active] 693977006426 catalytic site [active] 693977006427 FeoC like transcriptional regulator; Region: FeoC; cl17677 693977006428 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 693977006429 ferrous iron transporter FeoB; Region: feoB; TIGR00437 693977006430 G1 box; other site 693977006431 GTP/Mg2+ binding site [chemical binding]; other site 693977006432 Switch I region; other site 693977006433 G2 box; other site 693977006434 G3 box; other site 693977006435 Switch II region; other site 693977006436 G4 box; other site 693977006437 G5 box; other site 693977006438 Nucleoside recognition; Region: Gate; pfam07670 693977006439 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 693977006440 Nucleoside recognition; Region: Gate; pfam07670 693977006441 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 693977006442 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 693977006443 Carbon starvation protein CstA; Region: CstA; pfam02554 693977006444 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 693977006445 Carbon starvation protein CstA; Region: CstA; pfam02554 693977006446 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 693977006447 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693977006448 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693977006449 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693977006450 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 693977006451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693977006452 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693977006453 putative substrate translocation pore; other site 693977006454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693977006455 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 693977006456 active sites [active] 693977006457 tetramer interface [polypeptide binding]; other site 693977006458 imidazolonepropionase; Validated; Region: PRK09356 693977006459 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 693977006460 active site 693977006461 agmatinase; Region: agmatinase; TIGR01230 693977006462 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 693977006463 active site 693977006464 metal binding site [ion binding]; metal-binding site 693977006465 Protein of unknown function (DUF664); Region: DUF664; pfam04978 693977006466 DinB superfamily; Region: DinB_2; pfam12867 693977006467 urocanate hydratase; Provisional; Region: PRK05414 693977006468 Transcriptional regulator [Transcription]; Region: IclR; COG1414 693977006469 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 693977006470 Bacterial transcriptional regulator; Region: IclR; pfam01614 693977006471 CotH protein; Region: CotH; pfam08757 693977006472 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 693977006473 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 693977006474 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 693977006475 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 693977006476 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693977006477 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 693977006478 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 693977006479 C-terminal domain interface [polypeptide binding]; other site 693977006480 active site 693977006481 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 693977006482 active site 693977006483 N-terminal domain interface [polypeptide binding]; other site 693977006484 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 693977006485 substrate binding site [chemical binding]; other site 693977006486 active site 693977006487 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 693977006488 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 693977006489 GTPase RsgA; Reviewed; Region: PRK01889 693977006490 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 693977006491 RNA binding site [nucleotide binding]; other site 693977006492 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 693977006493 GTPase/Zn-binding domain interface [polypeptide binding]; other site 693977006494 GTP/Mg2+ binding site [chemical binding]; other site 693977006495 G4 box; other site 693977006496 G5 box; other site 693977006497 G1 box; other site 693977006498 Switch I region; other site 693977006499 G2 box; other site 693977006500 G3 box; other site 693977006501 Switch II region; other site 693977006502 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 693977006503 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 693977006504 G1 box; other site 693977006505 GTP/Mg2+ binding site [chemical binding]; other site 693977006506 G2 box; other site 693977006507 Switch I region; other site 693977006508 G3 box; other site 693977006509 Switch II region; other site 693977006510 G4 box; other site 693977006511 G5 box; other site 693977006512 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 693977006513 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 693977006514 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693977006515 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 693977006516 active site 693977006517 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 693977006518 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 693977006519 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 693977006520 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 693977006521 malonyl-CoA binding site [chemical binding]; other site 693977006522 dimer interface [polypeptide binding]; other site 693977006523 active site 693977006524 product binding site; other site 693977006525 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 693977006526 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693977006527 S-adenosylmethionine binding site [chemical binding]; other site 693977006528 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 693977006529 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 693977006530 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 693977006531 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 693977006532 Potassium binding sites [ion binding]; other site 693977006533 Cesium cation binding sites [ion binding]; other site 693977006534 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 693977006535 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 693977006536 XdhC Rossmann domain; Region: XdhC_C; pfam13478 693977006537 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 693977006538 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 693977006539 NAD(P) binding site [chemical binding]; other site 693977006540 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 693977006541 metal-binding site 693977006542 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 693977006543 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 693977006544 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693977006545 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 693977006546 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 693977006547 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 693977006548 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693977006549 catalytic loop [active] 693977006550 iron binding site [ion binding]; other site 693977006551 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 693977006552 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 693977006553 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 693977006554 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 693977006555 4Fe-4S binding domain; Region: Fer4_6; pfam12837 693977006556 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 693977006557 [4Fe-4S] binding site [ion binding]; other site 693977006558 molybdopterin cofactor binding site; other site 693977006559 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 693977006560 molybdopterin cofactor binding site; other site 693977006561 Protein of unknown function (DUF1641); Region: DUF1641; pfam07849 693977006562 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 693977006563 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 693977006564 active site 693977006565 catalytic residues [active] 693977006566 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 693977006567 IHF - DNA interface [nucleotide binding]; other site 693977006568 IHF dimer interface [polypeptide binding]; other site 693977006569 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 693977006570 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 693977006571 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 693977006572 metal-binding site [ion binding] 693977006573 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 693977006574 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 693977006575 Astacin (Peptidase family M12A); Region: Astacin; pfam01400 693977006576 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 693977006577 active site 693977006578 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 693977006579 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 693977006580 Homeodomain-like domain; Region: HTH_23; pfam13384 693977006581 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 693977006582 Homeodomain-like domain; Region: HTH_32; pfam13565 693977006583 Winged helix-turn helix; Region: HTH_33; pfam13592 693977006584 DDE superfamily endonuclease; Region: DDE_3; pfam13358 693977006585 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 693977006586 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693977006587 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 693977006588 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693977006589 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 693977006590 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 693977006591 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 693977006592 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693977006593 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 693977006594 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 693977006595 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 693977006596 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693977006597 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693977006598 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693977006599 Coenzyme A binding pocket [chemical binding]; other site 693977006600 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 693977006601 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 693977006602 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 693977006603 active site 693977006604 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 693977006605 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 693977006606 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 693977006607 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 693977006608 putative NADH binding site [chemical binding]; other site 693977006609 putative active site [active] 693977006610 nudix motif; other site 693977006611 putative metal binding site [ion binding]; other site 693977006612 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 693977006613 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693977006614 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 693977006615 Tetratricopeptide repeat; Region: TPR_12; pfam13424 693977006616 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693977006617 binding surface 693977006618 TPR motif; other site 693977006619 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693977006620 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693977006621 metal binding site [ion binding]; metal-binding site 693977006622 active site 693977006623 I-site; other site 693977006624 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693977006625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693977006626 putative substrate translocation pore; other site 693977006627 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 693977006628 HD domain; Region: HD_4; pfam13328 693977006629 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 693977006630 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 693977006631 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693977006632 ABC transporter signature motif; other site 693977006633 Walker B; other site 693977006634 D-loop; other site 693977006635 H-loop/switch region; other site 693977006636 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 693977006637 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 693977006638 dimerization interface [polypeptide binding]; other site 693977006639 metal binding site [ion binding]; metal-binding site 693977006640 C-terminal peptidase (prc); Region: prc; TIGR00225 693977006641 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 693977006642 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 693977006643 Active site serine [active] 693977006644 putative oxidoreductase; Provisional; Region: PRK11579 693977006645 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693977006646 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693977006647 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 693977006648 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 693977006649 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693977006650 NAD(P) binding site [chemical binding]; other site 693977006651 active site 693977006652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 693977006653 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 693977006654 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 693977006655 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 693977006656 dimer interface [polypeptide binding]; other site 693977006657 putative radical transfer pathway; other site 693977006658 diiron center [ion binding]; other site 693977006659 tyrosyl radical; other site 693977006660 ribonucleoside-diphosphate reductase, class 1b, alpha subunit; Region: RNR_1b_NrdE; TIGR04170 693977006661 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 693977006662 Class I ribonucleotide reductase; Region: RNR_I; cd01679 693977006663 active site 693977006664 dimer interface [polypeptide binding]; other site 693977006665 catalytic residues [active] 693977006666 effector binding site; other site 693977006667 R2 peptide binding site; other site 693977006668 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 693977006669 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 693977006670 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 693977006671 active site 693977006672 Int/Topo IB signature motif; other site 693977006673 catalytic residues [active] 693977006674 DNA binding site [nucleotide binding] 693977006675 PAS fold; Region: PAS_4; pfam08448 693977006676 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 693977006677 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693977006678 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693977006679 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 693977006680 EamA-like transporter family; Region: EamA; pfam00892 693977006681 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 693977006682 Isochorismatase family; Region: Isochorismatase; pfam00857 693977006683 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 693977006684 catalytic triad [active] 693977006685 conserved cis-peptide bond; other site 693977006686 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 693977006687 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 693977006688 GDSL-like Lipase/Acylhydrolase; Region: Lipase_GDSL; pfam00657 693977006689 active site 693977006690 catalytic triad [active] 693977006691 Protein of unknown function (DUF554); Region: DUF554; pfam04474 693977006692 Beta-lactamase; Region: Beta-lactamase; pfam00144 693977006693 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 693977006694 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693977006695 Predicted membrane protein [Function unknown]; Region: COG1511 693977006696 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 693977006697 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 693977006698 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693977006699 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693977006700 acyl-coenzyme A oxidase; Region: PLN02526 693977006701 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 693977006702 active site 693977006703 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 693977006704 Synechococcus sp. strain PCC 7942 PhoA and related proteins, N-terminal metallophosphatase domain; Region: MPP_PhoA_N; cd08162 693977006705 putative active site [active] 693977006706 putative metal binding site [ion binding]; other site 693977006707 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 693977006708 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 693977006709 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693977006710 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693977006711 metal binding site [ion binding]; metal-binding site 693977006712 active site 693977006713 I-site; other site 693977006714 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 693977006715 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 693977006716 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 693977006717 putative catalytic cysteine [active] 693977006718 gamma-glutamyl kinase; Provisional; Region: PRK05429 693977006719 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 693977006720 nucleotide binding site [chemical binding]; other site 693977006721 homotetrameric interface [polypeptide binding]; other site 693977006722 putative phosphate binding site [ion binding]; other site 693977006723 putative allosteric binding site; other site 693977006724 PUA domain; Region: PUA; pfam01472 693977006725 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 693977006726 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 693977006727 NAD(P) binding site [chemical binding]; other site 693977006728 catalytic residues [active] 693977006729 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 693977006730 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 693977006731 hydroxyglutarate oxidase; Provisional; Region: PRK11728 693977006732 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 693977006733 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 693977006734 GAF domain; Region: GAF; pfam01590 693977006735 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 693977006736 GAF domain; Region: GAF_3; pfam13492 693977006737 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693977006738 dimer interface [polypeptide binding]; other site 693977006739 phosphorylation site [posttranslational modification] 693977006740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693977006741 ATP binding site [chemical binding]; other site 693977006742 Mg2+ binding site [ion binding]; other site 693977006743 G-X-G motif; other site 693977006744 BON domain; Region: BON; pfam04972 693977006745 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 693977006746 classical (c) SDRs; Region: SDR_c; cd05233 693977006747 NAD(P) binding site [chemical binding]; other site 693977006748 active site 693977006749 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 693977006750 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 693977006751 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 693977006752 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 693977006753 active site 693977006754 phosphorylation site [posttranslational modification] 693977006755 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 693977006756 dimerization domain swap beta strand [polypeptide binding]; other site 693977006757 regulatory protein interface [polypeptide binding]; other site 693977006758 active site 693977006759 regulatory phosphorylation site [posttranslational modification]; other site 693977006760 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 693977006761 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 693977006762 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 693977006763 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 693977006764 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 693977006765 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 693977006766 putative substrate binding site [chemical binding]; other site 693977006767 putative ATP binding site [chemical binding]; other site 693977006768 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 693977006769 active site 693977006770 P-loop; other site 693977006771 phosphorylation site [posttranslational modification] 693977006772 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 693977006773 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 693977006774 S-adenosylmethionine binding site [chemical binding]; other site 693977006775 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693977006776 active site 693977006777 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 693977006778 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693977006779 putative homodimer interface [polypeptide binding]; other site 693977006780 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 693977006781 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693977006782 UDP-galactopyranose mutase; Region: GLF; pfam03275 693977006783 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 693977006784 kynureninase; Region: kynureninase; TIGR01814 693977006785 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693977006786 catalytic residue [active] 693977006787 Putative cyclase; Region: Cyclase; cl00814 693977006788 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 693977006789 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 693977006790 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 693977006791 NAD binding site [chemical binding]; other site 693977006792 catalytic Zn binding site [ion binding]; other site 693977006793 structural Zn binding site [ion binding]; other site 693977006794 Predicted integral membrane protein [Function unknown]; Region: COG5637 693977006795 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 693977006796 putative hydrophobic ligand binding site [chemical binding]; other site 693977006797 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 693977006798 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 693977006799 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 693977006800 calcium binding site 2 [ion binding]; other site 693977006801 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 693977006802 active site 693977006803 catalytic triad [active] 693977006804 calcium binding site 1 [ion binding]; other site 693977006805 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 693977006806 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693977006807 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 693977006808 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 693977006809 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 693977006810 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 693977006811 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 693977006812 dimer interface [polypeptide binding]; other site 693977006813 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693977006814 catalytic residue [active] 693977006815 serine O-acetyltransferase; Region: cysE; TIGR01172 693977006816 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 693977006817 trimer interface [polypeptide binding]; other site 693977006818 active site 693977006819 substrate binding site [chemical binding]; other site 693977006820 CoA binding site [chemical binding]; other site 693977006821 Transcriptional regulators [Transcription]; Region: FadR; COG2186 693977006822 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693977006823 DNA-binding site [nucleotide binding]; DNA binding site 693977006824 FCD domain; Region: FCD; pfam07729 693977006825 L-lactate permease; Region: Lactate_perm; cl00701 693977006826 glycolate transporter; Provisional; Region: PRK09695 693977006827 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 693977006828 Cysteine-rich domain; Region: CCG; pfam02754 693977006829 Cysteine-rich domain; Region: CCG; pfam02754 693977006830 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 693977006831 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 693977006832 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 693977006833 Uncharacterized conserved protein [Function unknown]; Region: COG1556 693977006834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693977006835 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693977006836 putative substrate translocation pore; other site 693977006837 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 693977006838 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693977006839 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693977006840 Walker A/P-loop; other site 693977006841 ATP binding site [chemical binding]; other site 693977006842 Q-loop/lid; other site 693977006843 ABC transporter signature motif; other site 693977006844 Walker B; other site 693977006845 D-loop; other site 693977006846 H-loop/switch region; other site 693977006847 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 693977006848 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693977006849 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693977006850 Walker A/P-loop; other site 693977006851 ATP binding site [chemical binding]; other site 693977006852 Q-loop/lid; other site 693977006853 ABC transporter signature motif; other site 693977006854 Walker B; other site 693977006855 D-loop; other site 693977006856 H-loop/switch region; other site 693977006857 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 693977006858 cleavage site 693977006859 active site 693977006860 substrate binding sites [chemical binding]; other site 693977006861 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 693977006862 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693977006863 dimer interface [polypeptide binding]; other site 693977006864 phosphorylation site [posttranslational modification] 693977006865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693977006866 ATP binding site [chemical binding]; other site 693977006867 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693977006868 G-X-G motif; other site 693977006869 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 693977006870 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 693977006871 NAD(P) binding site [chemical binding]; other site 693977006872 catalytic residues [active] 693977006873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 693977006874 HTH domain; Region: HTH_11; cl17392 693977006875 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 693977006876 MMPL family; Region: MMPL; pfam03176 693977006877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693977006878 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 693977006879 Response regulator receiver domain; Region: Response_reg; pfam00072 693977006880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693977006881 active site 693977006882 phosphorylation site [posttranslational modification] 693977006883 intermolecular recognition site; other site 693977006884 dimerization interface [polypeptide binding]; other site 693977006885 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 693977006886 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693977006887 dimerization interface [polypeptide binding]; other site 693977006888 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693977006889 dimer interface [polypeptide binding]; other site 693977006890 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 693977006891 putative CheW interface [polypeptide binding]; other site 693977006892 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693977006893 dimerization interface [polypeptide binding]; other site 693977006894 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693977006895 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693977006896 dimer interface [polypeptide binding]; other site 693977006897 putative CheW interface [polypeptide binding]; other site 693977006898 Hpt domain; Region: Hpt; pfam01627 693977006899 putative binding surface; other site 693977006900 active site 693977006901 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 693977006902 putative binding surface; other site 693977006903 active site 693977006904 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 693977006905 putative binding surface; other site 693977006906 active site 693977006907 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 693977006908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693977006909 ATP binding site [chemical binding]; other site 693977006910 G-X-G motif; other site 693977006911 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 693977006912 Response regulator receiver domain; Region: Response_reg; pfam00072 693977006913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693977006914 active site 693977006915 phosphorylation site [posttranslational modification] 693977006916 intermolecular recognition site; other site 693977006917 dimerization interface [polypeptide binding]; other site 693977006918 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 693977006919 Response regulator receiver domain; Region: Response_reg; pfam00072 693977006920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693977006921 active site 693977006922 phosphorylation site [posttranslational modification] 693977006923 intermolecular recognition site; other site 693977006924 dimerization interface [polypeptide binding]; other site 693977006925 Predicted membrane protein [Function unknown]; Region: COG2323 693977006926 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 693977006927 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 693977006928 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693977006929 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 693977006930 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 693977006931 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 693977006932 active site 693977006933 metal binding site [ion binding]; metal-binding site 693977006934 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 693977006935 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 693977006936 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 693977006937 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 693977006938 homodimer interface [polypeptide binding]; other site 693977006939 substrate-cofactor binding pocket; other site 693977006940 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693977006941 catalytic residue [active] 693977006942 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 693977006943 FAD binding site [chemical binding]; other site 693977006944 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 693977006945 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 693977006946 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 693977006947 substrate binding pocket [chemical binding]; other site 693977006948 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 693977006949 B12 binding site [chemical binding]; other site 693977006950 cobalt ligand [ion binding]; other site 693977006951 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 693977006952 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 693977006953 aromatic amino acid transport protein; Region: araaP; TIGR00837 693977006954 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 693977006955 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693977006956 Walker A/P-loop; other site 693977006957 ATP binding site [chemical binding]; other site 693977006958 Q-loop/lid; other site 693977006959 ABC transporter signature motif; other site 693977006960 Walker B; other site 693977006961 D-loop; other site 693977006962 H-loop/switch region; other site 693977006963 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693977006964 dimer interface [polypeptide binding]; other site 693977006965 conserved gate region; other site 693977006966 ABC-ATPase subunit interface; other site 693977006967 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 693977006968 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693977006969 membrane-bound complex binding site; other site 693977006970 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 693977006971 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 693977006972 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 693977006973 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 693977006974 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 693977006975 putative active site [active] 693977006976 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 693977006977 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 693977006978 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 693977006979 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 693977006980 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 693977006981 Replication initiator protein A; Region: RPA; cl17860 693977006982 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 693977006983 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693977006984 PAS domain; Region: PAS_9; pfam13426 693977006985 putative active site [active] 693977006986 heme pocket [chemical binding]; other site 693977006987 GAF domain; Region: GAF_3; pfam13492 693977006988 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 693977006989 GAF domain; Region: GAF_3; pfam13492 693977006990 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693977006991 dimer interface [polypeptide binding]; other site 693977006992 phosphorylation site [posttranslational modification] 693977006993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693977006994 ATP binding site [chemical binding]; other site 693977006995 Mg2+ binding site [ion binding]; other site 693977006996 G-X-G motif; other site 693977006997 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 693977006998 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693977006999 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693977007000 metal binding site [ion binding]; metal-binding site 693977007001 active site 693977007002 I-site; other site 693977007003 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 693977007004 active site 693977007005 DNA polymerase IV; Validated; Region: PRK02406 693977007006 DNA binding site [nucleotide binding] 693977007007 Predicted membrane protein [Function unknown]; Region: COG2855 693977007008 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 693977007009 MarR family; Region: MarR; pfam01047 693977007010 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693977007011 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 693977007012 Zn binding site [ion binding]; other site 693977007013 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 693977007014 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693977007015 Zn binding site [ion binding]; other site 693977007016 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 693977007017 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693977007018 Zn binding site [ion binding]; other site 693977007019 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 693977007020 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 693977007021 Zn binding site [ion binding]; other site 693977007022 Predicted esterase [General function prediction only]; Region: COG0400 693977007023 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 693977007024 catalytic site [active] 693977007025 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 693977007026 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 693977007027 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 693977007028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693977007029 putative substrate translocation pore; other site 693977007030 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693977007031 Predicted flavoprotein [General function prediction only]; Region: COG0431 693977007032 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 693977007033 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 693977007034 active site 693977007035 Predicted acetyltransferase [General function prediction only]; Region: COG2388 693977007036 Isochorismatase family; Region: Isochorismatase; pfam00857 693977007037 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 693977007038 catalytic triad [active] 693977007039 conserved cis-peptide bond; other site 693977007040 PhoD-like phosphatase; Region: PhoD; pfam09423 693977007041 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 693977007042 putative active site [active] 693977007043 putative metal binding site [ion binding]; other site 693977007044 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 693977007045 Rrf2 family protein; Region: rrf2_super; TIGR00738 693977007046 Transcriptional regulator; Region: Rrf2; pfam02082 693977007047 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693977007048 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693977007049 metal binding site [ion binding]; metal-binding site 693977007050 active site 693977007051 I-site; other site 693977007052 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693977007053 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 693977007054 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 693977007055 heme-binding site [chemical binding]; other site 693977007056 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 693977007057 FAD binding pocket [chemical binding]; other site 693977007058 FAD binding motif [chemical binding]; other site 693977007059 phosphate binding motif [ion binding]; other site 693977007060 beta-alpha-beta structure motif; other site 693977007061 NAD binding pocket [chemical binding]; other site 693977007062 Heme binding pocket [chemical binding]; other site 693977007063 BCCT family transporter; Region: BCCT; pfam02028 693977007064 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 693977007065 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693977007066 P-loop; other site 693977007067 Magnesium ion binding site [ion binding]; other site 693977007068 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693977007069 Magnesium ion binding site [ion binding]; other site 693977007070 ParB-like nuclease domain; Region: ParBc; pfam02195 693977007071 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 693977007072 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693977007073 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693977007074 metal binding site [ion binding]; metal-binding site 693977007075 active site 693977007076 I-site; other site 693977007077 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693977007078 mechanosensitive channel MscS; Provisional; Region: PRK10334 693977007079 Mechanosensitive ion channel; Region: MS_channel; pfam00924 693977007080 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 693977007081 manganese transport protein MntH; Reviewed; Region: PRK00701 693977007082 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 693977007083 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 693977007084 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 693977007085 ligand binding site [chemical binding]; other site 693977007086 NAD binding site [chemical binding]; other site 693977007087 dimerization interface [polypeptide binding]; other site 693977007088 catalytic site [active] 693977007089 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 693977007090 putative L-serine binding site [chemical binding]; other site 693977007091 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 693977007092 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693977007093 catalytic residue [active] 693977007094 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 693977007095 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693977007096 motif II; other site 693977007097 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 693977007098 TPR motif; other site 693977007099 binding surface 693977007100 WYL domain; Region: WYL; pfam13280 693977007101 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 693977007102 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 693977007103 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 693977007104 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 693977007105 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693977007106 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 693977007107 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 693977007108 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 693977007109 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 693977007110 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 693977007111 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 693977007112 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 693977007113 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 693977007114 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 693977007115 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693977007116 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 693977007117 putative ADP-binding pocket [chemical binding]; other site 693977007118 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 693977007119 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693977007120 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 693977007121 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693977007122 putative ADP-binding pocket [chemical binding]; other site 693977007123 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 693977007124 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693977007125 NAD(P) binding site [chemical binding]; other site 693977007126 active site 693977007127 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693977007128 AAA domain; Region: AAA_31; pfam13614 693977007129 Bacterial sugar transferase; Region: Bac_transf; pfam02397 693977007130 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693977007131 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693977007132 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 693977007133 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 693977007134 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 693977007135 Walker A/P-loop; other site 693977007136 ATP binding site [chemical binding]; other site 693977007137 Q-loop/lid; other site 693977007138 ABC transporter signature motif; other site 693977007139 Walker B; other site 693977007140 D-loop; other site 693977007141 H-loop/switch region; other site 693977007142 ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism]; Region: FepD; COG0609 693977007143 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 693977007144 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693977007145 putative PBP binding regions; other site 693977007146 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 693977007147 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 693977007148 siderophore binding site; other site 693977007149 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 693977007150 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693977007151 ABC-ATPase subunit interface; other site 693977007152 dimer interface [polypeptide binding]; other site 693977007153 putative PBP binding regions; other site 693977007154 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 693977007155 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 693977007156 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 693977007157 siderophore binding site; other site 693977007158 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 693977007159 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 693977007160 intersubunit interface [polypeptide binding]; other site 693977007161 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 693977007162 CoA-transferase family III; Region: CoA_transf_3; pfam02515 693977007163 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 693977007164 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 693977007165 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693977007166 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 693977007167 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 693977007168 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 693977007169 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693977007170 catalytic loop [active] 693977007171 iron binding site [ion binding]; other site 693977007172 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 693977007173 Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; cl01558 693977007174 Predicted membrane protein [Function unknown]; Region: COG2323 693977007175 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 693977007176 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693977007177 FeS/SAM binding site; other site 693977007178 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 693977007179 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 693977007180 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 693977007181 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 693977007182 putative dimer interface [polypeptide binding]; other site 693977007183 active site pocket [active] 693977007184 putative cataytic base [active] 693977007185 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 693977007186 homotrimer interface [polypeptide binding]; other site 693977007187 Walker A motif; other site 693977007188 GTP binding site [chemical binding]; other site 693977007189 Walker B motif; other site 693977007190 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 693977007191 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 693977007192 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 693977007193 catalytic triad [active] 693977007194 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 693977007195 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 693977007196 homodimer interface [polypeptide binding]; other site 693977007197 Walker A motif; other site 693977007198 ATP binding site [chemical binding]; other site 693977007199 hydroxycobalamin binding site [chemical binding]; other site 693977007200 Walker B motif; other site 693977007201 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 693977007202 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 693977007203 putative binding site residues; other site 693977007204 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 693977007205 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 693977007206 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 693977007207 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 693977007208 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 693977007209 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 693977007210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693977007211 dimer interface [polypeptide binding]; other site 693977007212 conserved gate region; other site 693977007213 putative PBP binding loops; other site 693977007214 ABC-ATPase subunit interface; other site 693977007215 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693977007216 Walker A/P-loop; other site 693977007217 ATP binding site [chemical binding]; other site 693977007218 ABC transporter; Region: ABC_tran; pfam00005 693977007219 Q-loop/lid; other site 693977007220 ABC transporter signature motif; other site 693977007221 Walker B; other site 693977007222 D-loop; other site 693977007223 H-loop/switch region; other site 693977007224 thymidine kinase; Provisional; Region: PRK04296 693977007225 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 693977007226 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 693977007227 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 693977007228 putative substrate binding pocket [chemical binding]; other site 693977007229 trimer interface [polypeptide binding]; other site 693977007230 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 693977007231 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 693977007232 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 693977007233 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 693977007234 tetramer interface [polypeptide binding]; other site 693977007235 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 693977007236 tetramer interface [polypeptide binding]; other site 693977007237 active site 693977007238 metal binding site [ion binding]; metal-binding site 693977007239 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 693977007240 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 693977007241 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 693977007242 putative active site [active] 693977007243 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693977007244 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 693977007245 NAD(P) binding site [chemical binding]; other site 693977007246 active site 693977007247 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 693977007248 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 693977007249 NAD binding site [chemical binding]; other site 693977007250 catalytic residues [active] 693977007251 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 693977007252 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 693977007253 active site 693977007254 catalytic site [active] 693977007255 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 693977007256 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693977007257 metal binding site [ion binding]; metal-binding site 693977007258 active site 693977007259 I-site; other site 693977007260 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 693977007261 Low molecular weight phosphatase family; Region: LMWPc; cd00115 693977007262 active site 693977007263 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 693977007264 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 693977007265 active site 693977007266 metal binding site [ion binding]; metal-binding site 693977007267 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693977007268 dimerization interface [polypeptide binding]; other site 693977007269 putative DNA binding site [nucleotide binding]; other site 693977007270 putative Zn2+ binding site [ion binding]; other site 693977007271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693977007272 Response regulator receiver domain; Region: Response_reg; pfam00072 693977007273 active site 693977007274 phosphorylation site [posttranslational modification] 693977007275 intermolecular recognition site; other site 693977007276 dimerization interface [polypeptide binding]; other site 693977007277 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 693977007278 heme-binding site [chemical binding]; other site