-- dump date   	20140619_060617
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
243230000001	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
243230000002	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
243230000003	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
243230000004	P-loop; other site
243230000005	Magnesium ion binding site [ion binding]; other site
243230000006	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
243230000007	ParB-like nuclease domain; Region: ParB; smart00470
243230000008	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
243230000009	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
243230000010	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
243230000011	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
243230000012	putative binding site residues; other site
243230000013	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
243230000014	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
243230000015	homodimer interface [polypeptide binding]; other site
243230000016	Walker A motif; other site
243230000017	ATP binding site [chemical binding]; other site
243230000018	hydroxycobalamin binding site [chemical binding]; other site
243230000019	Walker B motif; other site
243230000020	Cobyrinic acid a,c-diamide synthase [Coenzyme metabolism]; Region: CobB; COG1797
243230000021	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
243230000022	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
243230000023	catalytic triad [active]
243230000024	Cobalamin biosynthesis protein CobD/CbiB [Coenzyme metabolism]; Region: CbiB; COG1270
243230000025	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
243230000026	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243230000027	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243230000028	homodimer interface [polypeptide binding]; other site
243230000029	catalytic residue [active]
243230000030	cobyric acid synthase; Provisional; Region: PRK00784
243230000031	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
243230000032	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
243230000033	catalytic triad [active]
243230000034	Hemin binding protein HutB.  These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149
243230000035	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
243230000036	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
243230000037	ABC-ATPase subunit  interface; other site
243230000038	dimer interface [polypeptide binding]; other site
243230000039	putative PBP binding regions; other site
243230000040	ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559
243230000041	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
243230000042	Walker A/P-loop; other site
243230000043	ATP binding site [chemical binding]; other site
243230000044	Q-loop/lid; other site
243230000045	ABC transporter signature motif; other site
243230000046	Walker B; other site
243230000047	D-loop; other site
243230000048	H-loop/switch region; other site
243230000049	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
243230000050	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
243230000051	FAD binding pocket [chemical binding]; other site
243230000052	FAD binding motif [chemical binding]; other site
243230000053	phosphate binding motif [ion binding]; other site
243230000054	NAD binding pocket [chemical binding]; other site
243230000055	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
243230000056	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
243230000057	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
243230000058	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
243230000059	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
243230000060	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
243230000061	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243230000062	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243230000063	ATP binding site [chemical binding]; other site
243230000064	Mg2+ binding site [ion binding]; other site
243230000065	G-X-G motif; other site
243230000066	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
243230000067	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243230000068	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243230000069	ATP binding site [chemical binding]; other site
243230000070	Mg2+ binding site [ion binding]; other site
243230000071	G-X-G motif; other site
243230000072	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243230000073	dimer interface [polypeptide binding]; other site
243230000074	phosphorylation site [posttranslational modification]
243230000075	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243230000076	ATP binding site [chemical binding]; other site
243230000077	Mg2+ binding site [ion binding]; other site
243230000078	G-X-G motif; other site
243230000079	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243230000080	active site
243230000081	phosphorylation site [posttranslational modification]
243230000082	intermolecular recognition site; other site
243230000083	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243230000084	active site
243230000085	phosphorylation site [posttranslational modification]
243230000086	intermolecular recognition site; other site
243230000087	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243230000088	dimerization interface [polypeptide binding]; other site
243230000089	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243230000090	dimer interface [polypeptide binding]; other site
243230000091	phosphorylation site [posttranslational modification]
243230000092	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243230000093	ATP binding site [chemical binding]; other site
243230000094	Mg2+ binding site [ion binding]; other site
243230000095	G-X-G motif; other site
243230000096	ParB-like nuclease domain; Region: ParB; smart00470
243230000097	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
243230000098	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
243230000099	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
243230000100	P-loop; other site
243230000101	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
243230000102	Magnesium ion binding site [ion binding]; other site
243230000103	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
243230000104	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
243230000105	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
243230000106	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
243230000107	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243230000108	metal binding site [ion binding]; metal-binding site
243230000109	active site
243230000110	I-site; other site
243230000111	Domain of unknown function DUF11; Region: DUF11; pfam01345
243230000112	Domain of unknown function DUF11; Region: DUF11; pfam01345
243230000113	Domain of unknown function DUF11; Region: DUF11; pfam01345
243230000114	Domain of unknown function DUF11; Region: DUF11; pfam01345
243230000115	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
243230000116	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
243230000117	Major Facilitator Superfamily; Region: MFS_1; pfam07690
243230000118	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243230000119	putative substrate translocation pore; other site
243230000120	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
243230000121	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243230000122	metal binding site [ion binding]; metal-binding site
243230000123	active site
243230000124	I-site; other site
243230000125	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
243230000126	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243230000127	Walker A/P-loop; other site
243230000128	ATP binding site [chemical binding]; other site
243230000129	Q-loop/lid; other site
243230000130	ABC transporter signature motif; other site
243230000131	Walker B; other site
243230000132	D-loop; other site
243230000133	H-loop/switch region; other site
243230000134	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
243230000135	FtsX-like permease family; Region: FtsX; pfam02687
243230000136	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412
243230000137	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: Peptidase_C93; cl17596
243230000138	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
243230000139	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
243230000140	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
243230000141	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
243230000142	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
243230000143	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
243230000144	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
243230000145	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
243230000146	Bacterial Ig-like domain 2; Region: BID_2; smart00635
243230000147	Uncharacterized nucleotidyltransferase; Region: NTP_transf_5; pfam14907
243230000148	Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471
243230000149	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
243230000150	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
243230000151	generic binding surface II; other site
243230000152	generic binding surface I; other site
243230000153	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
243230000154	putative active site [active]
243230000155	putative catalytic site [active]
243230000156	putative Mg binding site IVb [ion binding]; other site
243230000157	putative phosphate binding site [ion binding]; other site
243230000158	putative DNA binding site [nucleotide binding]; other site
243230000159	putative Mg binding site IVa [ion binding]; other site
243230000160	Fimbrial protein; Region: Fimbrial; cl01416
243230000161	Lamin Tail Domain; Region: LTD; pfam00932
243230000162	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
243230000163	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
243230000164	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
243230000165	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
243230000166	active site
243230000167	catalytic residues [active]
243230000168	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
243230000169	HprK-related kinase A; Region: HprK_rel_A; TIGR04352
243230000170	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402
243230000171	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
243230000172	Squalene epoxidase; Region: SE; cl17314
243230000173	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
243230000174	active site
243230000175	P-loop; other site
243230000176	phosphorylation site [posttranslational modification]
243230000177	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
243230000178	active site
243230000179	P-loop; other site
243230000180	phosphorylation site [posttranslational modification]
243230000181	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
243230000182	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
243230000183	putative substrate binding site [chemical binding]; other site
243230000184	putative ATP binding site [chemical binding]; other site
243230000185	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
243230000186	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
243230000187	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
243230000188	Uncharacterized conserved protein [Function unknown]; Region: COG3375
243230000189	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230000190	Coenzyme A binding pocket [chemical binding]; other site
243230000191	N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317
243230000192	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
243230000193	active site
243230000194	octamer interface [polypeptide binding]; other site
243230000195	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
243230000196	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243230000197	NAD(P) binding site [chemical binding]; other site
243230000198	active site
243230000199	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
243230000200	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243230000201	active site
243230000202	phosphorylation site [posttranslational modification]
243230000203	intermolecular recognition site; other site
243230000204	dimerization interface [polypeptide binding]; other site
243230000205	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
243230000206	DNA binding residues [nucleotide binding]
243230000207	dimerization interface [polypeptide binding]; other site
243230000208	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
243230000209	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
243230000210	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
243230000211	F subunit of K+-transporting ATPase (Potass_KdpF); Region: Potass_KdpF; pfam09604
243230000212	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
243230000213	K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156
243230000214	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
243230000215	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
243230000216	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
243230000217	Ligand Binding Site [chemical binding]; other site
243230000218	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243230000219	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243230000220	dimer interface [polypeptide binding]; other site
243230000221	phosphorylation site [posttranslational modification]
243230000222	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243230000223	ATP binding site [chemical binding]; other site
243230000224	Mg2+ binding site [ion binding]; other site
243230000225	G-X-G motif; other site
243230000226	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
243230000227	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243230000228	active site
243230000229	phosphorylation site [posttranslational modification]
243230000230	intermolecular recognition site; other site
243230000231	dimerization interface [polypeptide binding]; other site
243230000232	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
243230000233	DNA binding site [nucleotide binding]
243230000234	Ferritin-like domain; Region: Ferritin; pfam00210
243230000235	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
243230000236	dimerization interface [polypeptide binding]; other site
243230000237	DPS ferroxidase diiron center [ion binding]; other site
243230000238	ion pore; other site
243230000239	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243230000240	metal binding site [ion binding]; metal-binding site
243230000241	active site
243230000242	I-site; other site
243230000243	RNA ligase, DRB0094 family; Region: RNA_lig_DRB0094; TIGR02306
243230000244	The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320
243230000245	putative tRNA-binding site [nucleotide binding]; other site
243230000246	RNA ligase; Region: RNA_ligase; pfam09414
243230000247	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
243230000248	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
243230000249	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
243230000250	Putative lysophospholipase; Region: Hydrolase_4; cl19140
243230000251	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
243230000252	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243230000253	Zn2+ binding site [ion binding]; other site
243230000254	Mg2+ binding site [ion binding]; other site
243230000255	Predicted kinase [General function prediction only]; Region: COG4639
243230000256	AAA domain; Region: AAA_33; pfam13671
243230000257	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4295
243230000258	RNA ligase; Region: RNA_ligase; cl19220
243230000259	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
243230000260	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
243230000261	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
243230000262	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
243230000263	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
243230000264	active site
243230000265	DNA binding site [nucleotide binding]
243230000266	Int/Topo IB signature motif; other site
243230000267	Regulator of G protein signaling (RGS) domain superfamily; Region: RGS; cl02565
243230000268	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
243230000269	Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780
243230000270	ribonucleoside-diphosphate reductase, class 1b, alpha subunit; Region: RNR_1b_NrdE; TIGR04170
243230000271	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
243230000272	Class I ribonucleotide reductase; Region: RNR_I; cd01679
243230000273	active site
243230000274	dimer interface [polypeptide binding]; other site
243230000275	catalytic residues [active]
243230000276	effector binding site; other site
243230000277	R2 peptide binding site; other site
243230000278	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
243230000279	dimer interface [polypeptide binding]; other site
243230000280	putative radical transfer pathway; other site
243230000281	diiron center [ion binding]; other site
243230000282	tyrosyl radical; other site
243230000283	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
243230000284	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
243230000285	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
243230000286	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
243230000287	putative active site [active]
243230000288	catalytic site [active]
243230000289	putative metal binding site [ion binding]; other site
243230000290	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
243230000291	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
243230000292	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
243230000293	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
243230000294	Predicted secreted protein [Function unknown]; Region: COG5497
243230000295	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
243230000296	Ferritin-like domain; Region: Ferritin_2; pfam13668
243230000297	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
243230000298	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
243230000299	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
243230000300	Walker A/P-loop; other site
243230000301	ATP binding site [chemical binding]; other site
243230000302	Q-loop/lid; other site
243230000303	ABC transporter signature motif; other site
243230000304	Walker B; other site
243230000305	D-loop; other site
243230000306	H-loop/switch region; other site
243230000307	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
243230000308	ABC-ATPase subunit  interface; other site
243230000309	dimer interface [polypeptide binding]; other site
243230000310	putative PBP binding regions; other site
243230000311	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
243230000312	ABC-ATPase subunit  interface; other site
243230000313	dimer interface [polypeptide binding]; other site
243230000314	putative PBP binding regions; other site
243230000315	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
243230000316	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
243230000317	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
243230000318	FAD binding pocket [chemical binding]; other site
243230000319	FAD binding motif [chemical binding]; other site
243230000320	phosphate binding motif [ion binding]; other site
243230000321	NAD binding pocket [chemical binding]; other site
243230000322	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
243230000323	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
243230000324	siderophore binding site; other site
243230000325	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243230000326	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
243230000327	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
243230000328	Domain of unknown function DUF21; Region: DUF21; pfam01595
243230000329	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
243230000330	Transporter associated domain; Region: CorC_HlyC; pfam03471
243230000331	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
243230000332	Domain of unknown function DUF21; Region: DUF21; pfam01595
243230000333	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
243230000334	Transporter associated domain; Region: CorC_HlyC; pfam03471
243230000335	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
243230000336	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
243230000337	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
243230000338	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
243230000339	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
243230000340	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
243230000341	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
243230000342	ATP binding site [chemical binding]; other site
243230000343	putative Mg++ binding site [ion binding]; other site
243230000344	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243230000345	ATP-binding site [chemical binding]; other site
243230000346	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
243230000347	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
243230000348	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
243230000349	ATP binding site [chemical binding]; other site
243230000350	putative Mg++ binding site [ion binding]; other site
243230000351	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243230000352	nucleotide binding region [chemical binding]; other site
243230000353	ATP-binding site [chemical binding]; other site
243230000354	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
243230000355	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
243230000356	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
243230000357	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
243230000358	6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131
243230000359	HicB family; Region: HicB; pfam05534
243230000360	GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401
243230000361	Restriction endonuclease; Region: Mrr_cat; cl19295
243230000362	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
243230000363	McrBC 5-methylcytosine restriction system component [Defense mechanisms]; Region: McrC; COG4268
243230000364	Plasmid replication initiator protein [DNA replication, recombination, and repair]; Region: COG5534
243230000365	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
243230000366	Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574
243230000367	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
243230000368	Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574
243230000369	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
243230000370	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
243230000371	Winged helix-turn helix; Region: HTH_33; pfam13592
243230000372	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
243230000373	multiple promoter invertase; Provisional; Region: mpi; PRK13413
243230000374	catalytic residues [active]
243230000375	catalytic nucleophile [active]
243230000376	Presynaptic Site I dimer interface [polypeptide binding]; other site
243230000377	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
243230000378	Synaptic Flat tetramer interface [polypeptide binding]; other site
243230000379	Synaptic Site I dimer interface [polypeptide binding]; other site
243230000380	DNA binding site [nucleotide binding]
243230000381	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569
243230000382	DNA-binding interface [nucleotide binding]; DNA binding site
243230000383	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
243230000384	active site
243230000385	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
243230000386	Ligand Binding Site [chemical binding]; other site
243230000387	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
243230000388	Catalytic GIY-YIG domain of type II restriction endonucleases R.Eco29kI, R.Cfr42I, and similar proteins; Region: GIY-YIG_RE_Eco29kI_like; cd10435
243230000389	GIY-YIG motif/motif A; other site
243230000390	active site
243230000391	DNA binding site [nucleotide binding]
243230000392	homodimer interface [polypeptide binding]; other site
243230000393	putative metal binding site [ion binding]; other site
243230000394	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
243230000395	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
243230000396	DNA binding residues [nucleotide binding]
243230000397	dimerization interface [polypeptide binding]; other site
243230000398	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
243230000399	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
243230000400	active site
243230000401	metal binding site [ion binding]; metal-binding site
243230000402	FOG: WD40-like repeat [Function unknown]; Region: COG1520
243230000403	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
243230000404	active site
243230000405	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
243230000406	Transposase and inactivated derivatives, TnpA family [DNA replication, recombination, and repair]; Region: COG4644
243230000407	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
243230000408	active site
243230000409	catalytic residues [active]
243230000410	DNA binding site [nucleotide binding]
243230000411	Int/Topo IB signature motif; other site
243230000412	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
243230000413	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
243230000414	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
243230000415	P-loop; other site
243230000416	Magnesium ion binding site [ion binding]; other site
243230000417	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
243230000418	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
243230000419	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
243230000420	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
243230000421	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
243230000422	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
243230000423	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
243230000424	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
243230000425	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243230000426	FeS/SAM binding site; other site
243230000427	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
243230000428	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
243230000429	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
243230000430	B12 binding site [chemical binding]; other site
243230000431	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243230000432	FeS/SAM binding site; other site
243230000433	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
243230000434	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
243230000435	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243230000436	H+ Antiporter protein; Region: 2A0121; TIGR00900
243230000437	putative substrate translocation pore; other site
243230000438	DNA polymerase III subunit beta; Provisional; Region: PRK14945
243230000439	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
243230000440	putative DNA binding surface [nucleotide binding]; other site
243230000441	dimer interface [polypeptide binding]; other site
243230000442	beta-clamp/translesion DNA polymerase binding surface; other site
243230000443	beta-clamp/clamp loader binding surface; other site
243230000444	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
243230000445	DnaA N-terminal domain; Region: DnaA_N; pfam11638
243230000446	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243230000447	Walker A motif; other site
243230000448	ATP binding site [chemical binding]; other site
243230000449	Walker B motif; other site
243230000450	arginine finger; other site
243230000451	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
243230000452	DnaA box-binding interface [nucleotide binding]; other site
243230000453	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
243230000454	nudix motif; other site
243230000455	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680
243230000456	nudix motif; other site
243230000457	Predicted transcriptional regulators [Transcription]; Region: COG1378
243230000458	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
243230000459	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
243230000460	putative active site [active]
243230000461	catalytic site [active]
243230000462	metal-dependent hydrolase; Provisional; Region: PRK00685
243230000463	Uncharacterized conserved protein [Function unknown]; Region: COG1624
243230000464	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
243230000465	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
243230000466	YbbR-like protein; Region: YbbR; pfam07949
243230000467	Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720
243230000468	VanW like protein; Region: VanW; pfam04294
243230000469	G5 domain; Region: G5; pfam07501
243230000470	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
243230000471	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
243230000472	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
243230000473	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
243230000474	NADP binding site [chemical binding]; other site
243230000475	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
243230000476	ParB-like nuclease domain; Region: ParB; smart00470
243230000477	KorB domain; Region: KorB; pfam08535
243230000478	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
243230000479	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
243230000480	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
243230000481	P-loop; other site
243230000482	Magnesium ion binding site [ion binding]; other site
243230000483	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
243230000484	Methyltransferase domain; Region: Methyltransf_31; pfam13847
243230000485	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243230000486	S-adenosylmethionine binding site [chemical binding]; other site
243230000487	excinuclease ABC, C subunit; Region: uvrC; TIGR00194
243230000488	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
243230000489	NAD+ binding site [chemical binding]; other site
243230000490	substrate binding site [chemical binding]; other site
243230000491	Zn binding site [ion binding]; other site
243230000492	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3877
243230000493	Exoribonuclease R [Transcription]; Region: VacB; COG0557
243230000494	RNB domain; Region: RNB; pfam00773
243230000495	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035
243230000496	putative uracil binding site [chemical binding]; other site
243230000497	putative active site [active]
243230000498	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
243230000499	phosphoribosylaminoimidazole carboxylase, PurK protein; Region: purK; TIGR01161
243230000500	ATP-grasp domain; Region: ATP-grasp_4; cl17255
243230000501	Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720
243230000502	VanW like protein; Region: VanW; pfam04294
243230000503	Methyltransferase domain; Region: Methyltransf_31; pfam13847
243230000504	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243230000505	S-adenosylmethionine binding site [chemical binding]; other site
243230000506	Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445
243230000507	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
243230000508	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
243230000509	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
243230000510	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
243230000511	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
243230000512	catalytic residue [active]
243230000513	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
243230000514	tetramer interface [polypeptide binding]; other site
243230000515	TPP-binding site [chemical binding]; other site
243230000516	heterodimer interface [polypeptide binding]; other site
243230000517	phosphorylation loop region [posttranslational modification]
243230000518	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
243230000519	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
243230000520	alpha subunit interface [polypeptide binding]; other site
243230000521	TPP binding site [chemical binding]; other site
243230000522	heterodimer interface [polypeptide binding]; other site
243230000523	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
243230000524	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
243230000525	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
243230000526	E3 interaction surface; other site
243230000527	lipoyl attachment site [posttranslational modification]; other site
243230000528	e3 binding domain; Region: E3_binding; pfam02817
243230000529	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
243230000530	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
243230000531	homotrimer interaction site [polypeptide binding]; other site
243230000532	putative active site [active]
243230000533	Domain of unknown function (DUF4180); Region: DUF4180; pfam13788
243230000534	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
243230000535	GDP-binding site [chemical binding]; other site
243230000536	ACT binding site; other site
243230000537	IMP binding site; other site
243230000538	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
243230000539	homodecamer interface [polypeptide binding]; other site
243230000540	active site
243230000541	putative catalytic site residues [active]
243230000542	zinc binding site [ion binding]; other site
243230000543	GTP-CH-I/GFRP interaction surface; other site
243230000544	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
243230000545	dimer interface [polypeptide binding]; other site
243230000546	active site
243230000547	glycine-pyridoxal phosphate binding site [chemical binding]; other site
243230000548	folate binding site [chemical binding]; other site
243230000549	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
243230000550	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
243230000551	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
243230000552	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243230000553	Zn2+ binding site [ion binding]; other site
243230000554	Mg2+ binding site [ion binding]; other site
243230000555	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
243230000556	active site
243230000557	metal binding site [ion binding]; metal-binding site
243230000558	Uncharacterized conserved protein [Function unknown]; Region: COG3375
243230000559	N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317
243230000560	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
243230000561	active site
243230000562	octamer interface [polypeptide binding]; other site
243230000563	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3644
243230000564	Leucine rich repeat variant; Region: LRV; pfam01816
243230000565	Predicted membrane protein [Function unknown]; Region: COG2323
243230000566	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
243230000567	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
243230000568	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
243230000569	putative RNA binding site [nucleotide binding]; other site
243230000570	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243230000571	S-adenosylmethionine binding site [chemical binding]; other site
243230000572	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318
243230000573	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
243230000574	Uncharacterized conserved protein [Function unknown]; Region: COG3246
243230000575	DinB family; Region: DinB; pfam05163
243230000576	Uncharacterized conserved protein [Function unknown]; Region: COG1416
243230000577	Predicted transcriptional regulator [Transcription]; Region: COG2378
243230000578	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
243230000579	dimerization interface [polypeptide binding]; other site
243230000580	putative Zn2+ binding site [ion binding]; other site
243230000581	putative DNA binding site [nucleotide binding]; other site
243230000582	WYL domain; Region: WYL; pfam13280
243230000583	Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
243230000584	Benzoate membrane transport protein; Region: BenE; pfam03594
243230000585	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
243230000586	catalytic residues [active]
243230000587	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
243230000588	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
243230000589	active site
243230000590	ATP binding site [chemical binding]; other site
243230000591	substrate binding site [chemical binding]; other site
243230000592	activation loop (A-loop); other site
243230000593	Uncharacterized conserved protein [Function unknown]; Region: COG3391
243230000594	NHL repeat; Region: NHL; pfam01436
243230000595	Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015
243230000596	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
243230000597	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
243230000598	Walker A/P-loop; other site
243230000599	ATP binding site [chemical binding]; other site
243230000600	Q-loop/lid; other site
243230000601	ABC transporter signature motif; other site
243230000602	Walker B; other site
243230000603	D-loop; other site
243230000604	H-loop/switch region; other site
243230000605	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
243230000606	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
243230000607	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243230000608	FeS/SAM binding site; other site
243230000609	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
243230000610	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
243230000611	ATP binding site [chemical binding]; other site
243230000612	putative Mg++ binding site [ion binding]; other site
243230000613	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243230000614	nucleotide binding region [chemical binding]; other site
243230000615	ATP-binding site [chemical binding]; other site
243230000616	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
243230000617	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
243230000618	Phosphotransferase enzyme family; Region: APH; pfam01636
243230000619	active site
243230000620	ATP binding site [chemical binding]; other site
243230000621	antibiotic binding site [chemical binding]; other site
243230000622	DdrB-like protein; Region: DdrB; pfam12747
243230000623	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
243230000624	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
243230000625	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
243230000626	phosphate acetyltransferase; Reviewed; Region: PRK05632
243230000627	DRTGG domain; Region: DRTGG; pfam07085
243230000628	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
243230000629	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243230000630	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
243230000631	Predicted membrane protein [Function unknown]; Region: COG1511
243230000632	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580
243230000633	Predicted membrane protein [Function unknown]; Region: COG1511
243230000634	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
243230000635	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
243230000636	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
243230000637	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
243230000638	dimer interface [polypeptide binding]; other site
243230000639	putative functional site; other site
243230000640	putative MPT binding site; other site
243230000641	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
243230000642	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
243230000643	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
243230000644	shikimate binding site; other site
243230000645	NAD(P) binding site [chemical binding]; other site
243230000646	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
243230000647	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
243230000648	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
243230000649	nudix motif; other site
243230000650	ornithine carbamoyltransferase; Provisional; Region: PRK00779
243230000651	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
243230000652	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
243230000653	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
243230000654	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
243230000655	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
243230000656	E3 interaction surface; other site
243230000657	lipoyl attachment site [posttranslational modification]; other site
243230000658	e3 binding domain; Region: E3_binding; pfam02817
243230000659	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
243230000660	GTPase CgtA; Reviewed; Region: obgE; PRK12297
243230000661	GTP1/OBG; Region: GTP1_OBG; pfam01018
243230000662	Obg GTPase; Region: Obg; cd01898
243230000663	G1 box; other site
243230000664	GTP/Mg2+ binding site [chemical binding]; other site
243230000665	Switch I region; other site
243230000666	G2 box; other site
243230000667	G3 box; other site
243230000668	Switch II region; other site
243230000669	G4 box; other site
243230000670	G5 box; other site
243230000671	Domain of unknown function (DUF1967); Region: DUF1967; cl07779
243230000672	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
243230000673	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
243230000674	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
243230000675	ATP cone domain; Region: ATP-cone; pfam03477
243230000676	classical (c) SDRs; Region: SDR_c; cd05233
243230000677	NAD(P) binding site [chemical binding]; other site
243230000678	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
243230000679	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
243230000680	active site
243230000681	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
243230000682	putative acyl-acceptor binding pocket; other site
243230000683	Predicted membrane protein [Function unknown]; Region: COG2324
243230000684	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
243230000685	nudix motif; other site
243230000686	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
243230000687	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
243230000688	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
243230000689	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
243230000690	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
243230000691	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243230000692	Walker A/P-loop; other site
243230000693	ATP binding site [chemical binding]; other site
243230000694	Q-loop/lid; other site
243230000695	ABC transporter signature motif; other site
243230000696	Walker B; other site
243230000697	D-loop; other site
243230000698	H-loop/switch region; other site
243230000699	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
243230000700	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
243230000701	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243230000702	Walker A/P-loop; other site
243230000703	ATP binding site [chemical binding]; other site
243230000704	Q-loop/lid; other site
243230000705	ABC transporter signature motif; other site
243230000706	Walker B; other site
243230000707	D-loop; other site
243230000708	H-loop/switch region; other site
243230000709	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293
243230000710	Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Region: RpsF; COG0360
243230000711	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
243230000712	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
243230000713	dimer interface [polypeptide binding]; other site
243230000714	ssDNA binding site [nucleotide binding]; other site
243230000715	tetramer (dimer of dimers) interface [polypeptide binding]; other site
243230000716	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
243230000717	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
243230000718	dimer interface [polypeptide binding]; other site
243230000719	ssDNA binding site [nucleotide binding]; other site
243230000720	tetramer (dimer of dimers) interface [polypeptide binding]; other site
243230000721	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
243230000722	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
243230000723	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
243230000724	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
243230000725	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
243230000726	Predicted integral membrane protein [Function unknown]; Region: COG5530
243230000727	multidrug efflux protein NorA; Provisional; Region: PRK00187
243230000728	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
243230000729	cation binding site [ion binding]; other site
243230000730	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
243230000731	MMPL family; Region: MMPL; cl14618
243230000732	MMPL family; Region: MMPL; cl14618
243230000733	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
243230000734	dimer interface [polypeptide binding]; other site
243230000735	putative metal binding site [ion binding]; other site
243230000736	Uncharacterized conserved protein [Function unknown]; Region: COG0327
243230000737	thymidylate kinase; Validated; Region: tmk; PRK00698
243230000738	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
243230000739	TMP-binding site; other site
243230000740	ATP-binding site [chemical binding]; other site
243230000741	Glutamine cyclotransferase; Region: Glu_cyclase_2; pfam05096
243230000742	short chain dehydrogenase; Provisional; Region: PRK07576
243230000743	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
243230000744	NAD(P) binding site [chemical binding]; other site
243230000745	substrate binding site [chemical binding]; other site
243230000746	homotetramer interface [polypeptide binding]; other site
243230000747	active site
243230000748	homodimer interface [polypeptide binding]; other site
243230000749	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
243230000750	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
243230000751	substrate binding site [chemical binding]; other site
243230000752	oxyanion hole (OAH) forming residues; other site
243230000753	trimer interface [polypeptide binding]; other site
243230000754	S-layer homology domain; Region: SLH; pfam00395
243230000755	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
243230000756	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
243230000757	ATP-grasp domain; Region: ATP-grasp_4; cl17255
243230000758	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
243230000759	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
243230000760	carboxyltransferase (CT) interaction site; other site
243230000761	biotinylation site [posttranslational modification]; other site
243230000762	elongation factor P; Validated; Region: PRK00529
243230000763	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
243230000764	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
243230000765	RNA binding site [nucleotide binding]; other site
243230000766	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
243230000767	RNA binding site [nucleotide binding]; other site
243230000768	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
243230000769	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
243230000770	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
243230000771	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243230000772	TPR motif; other site
243230000773	binding surface
243230000774	TPR repeat; Region: TPR_11; pfam13414
243230000775	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243230000776	binding surface
243230000777	TPR motif; other site
243230000778	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243230000779	TPR motif; other site
243230000780	binding surface
243230000781	Sulfatase; Region: Sulfatase; cl19157
243230000782	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
243230000783	active site
243230000784	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
243230000785	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230000786	Coenzyme A binding pocket [chemical binding]; other site
243230000787	chaperone protein DnaJ; Provisional; Region: PRK14299
243230000788	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
243230000789	HSP70 interaction site [polypeptide binding]; other site
243230000790	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
243230000791	substrate binding site [polypeptide binding]; other site
243230000792	dimer interface [polypeptide binding]; other site
243230000793	Uncharacterized conserved protein [Function unknown]; Region: COG4628
243230000794	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
243230000795	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
243230000796	dimer interface [polypeptide binding]; other site
243230000797	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
243230000798	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
243230000799	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
243230000800	nucleotide binding site [chemical binding]; other site
243230000801	NEF interaction site [polypeptide binding]; other site
243230000802	SBD interface [polypeptide binding]; other site
243230000803	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
243230000804	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243230000805	FeS/SAM binding site; other site
243230000806	HemN C-terminal domain; Region: HemN_C; pfam06969
243230000807	e3 binding domain; Region: E3_binding; pfam02817
243230000808	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
243230000809	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
243230000810	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
243230000811	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
243230000812	MOSC domain; Region: MOSC; pfam03473
243230000813	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
243230000814	EamA-like transporter family; Region: EamA; pfam00892
243230000815	EamA-like transporter family; Region: EamA; pfam00892
243230000816	Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977
243230000817	catalytic residue [active]
243230000818	Predicted type IV restriction endonuclease [Defense mechanisms]; Region: COG2810
243230000819	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
243230000820	Domain of unknown function (DUF4357); Region: DUF4357; pfam14267
243230000821	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296
243230000822	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
243230000823	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
243230000824	HflX GTPase family; Region: HflX; cd01878
243230000825	G1 box; other site
243230000826	GTP/Mg2+ binding site [chemical binding]; other site
243230000827	Switch I region; other site
243230000828	G2 box; other site
243230000829	G3 box; other site
243230000830	Switch II region; other site
243230000831	G4 box; other site
243230000832	G5 box; other site
243230000833	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
243230000834	Domain of unknown function DUF11; Region: DUF11; pfam01345
243230000835	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
243230000836	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
243230000837	Domain of unknown function DUF11; Region: DUF11; pfam01345
243230000838	Domain of unknown function DUF11; Region: DUF11; pfam01345
243230000839	Domain of unknown function DUF11; Region: DUF11; pfam01345
243230000840	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
243230000841	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
243230000842	active site
243230000843	HEPN domain; Region: HEPN; cl00824
243230000844	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
243230000845	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
243230000846	active site
243230000847	HIGH motif; other site
243230000848	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
243230000849	KMSKS motif; other site
243230000850	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
243230000851	tRNA binding surface [nucleotide binding]; other site
243230000852	anticodon binding site; other site
243230000853	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
243230000854	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
243230000855	nudix motif; other site
243230000856	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
243230000857	cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976
243230000858	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
243230000859	catalytic residue [active]
243230000860	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
243230000861	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
243230000862	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
243230000863	catalytic motif [active]
243230000864	Zn binding site [ion binding]; other site
243230000865	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
243230000866	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
243230000867	Lumazine binding domain; Region: Lum_binding; pfam00677
243230000868	Lumazine binding domain; Region: Lum_binding; pfam00677
243230000869	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
243230000870	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
243230000871	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
243230000872	dimerization interface [polypeptide binding]; other site
243230000873	active site
243230000874	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
243230000875	homopentamer interface [polypeptide binding]; other site
243230000876	active site
243230000877	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
243230000878	Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812
243230000879	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
243230000880	NAD binding site [chemical binding]; other site
243230000881	Phe binding site; other site
243230000882	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
243230000883	ATP-binding site [chemical binding]; other site
243230000884	Sugar specificity; other site
243230000885	Pyrimidine base specificity; other site
243230000886	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
243230000887	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
243230000888	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
243230000889	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243230000890	Walker A/P-loop; other site
243230000891	ATP binding site [chemical binding]; other site
243230000892	Q-loop/lid; other site
243230000893	ABC transporter signature motif; other site
243230000894	Walker B; other site
243230000895	D-loop; other site
243230000896	H-loop/switch region; other site
243230000897	Uncharacterized conserved protein [Function unknown]; Region: COG3868
243230000898	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
243230000899	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
243230000900	Acyl-CoA-binding protein [Lipid metabolism]; Region: ACB; COG4281
243230000901	acyl-CoA binding pocket [chemical binding]; other site
243230000902	CoA binding site [chemical binding]; other site
243230000903	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
243230000904	Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294
243230000905	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
243230000906	substrate binding pocket [chemical binding]; other site
243230000907	dimer interface [polypeptide binding]; other site
243230000908	inhibitor binding site; inhibition site
243230000909	dihydroneopterin aldolase; Region: folB; TIGR00525
243230000910	active site
243230000911	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
243230000912	catalytic center binding site [active]
243230000913	ATP binding site [chemical binding]; other site
243230000914	Helix-turn-helix domain; Region: HTH_20; pfam12840
243230000915	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
243230000916	peptide chain release factor 2; Validated; Region: prfB; PRK00578
243230000917	PCRF domain; Region: PCRF; pfam03462
243230000918	RF-1 domain; Region: RF-1; pfam00472
243230000919	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
243230000920	23S rRNA interface [nucleotide binding]; other site
243230000921	L3 interface [polypeptide binding]; other site
243230000922	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
243230000923	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
243230000924	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191
243230000925	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
243230000926	Transposase IS200 like; Region: Y1_Tnp; pfam01797
243230000927	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
243230000928	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
243230000929	Probable transposase; Region: OrfB_IS605; pfam01385
243230000930	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
243230000931	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
243230000932	active site
243230000933	dimerization interface [polypeptide binding]; other site
243230000934	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
243230000935	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
243230000936	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
243230000937	DNA binding residues [nucleotide binding]
243230000938	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
243230000939	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691
243230000940	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
243230000941	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
243230000942	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
243230000943	active site
243230000944	dimer interface [polypeptide binding]; other site
243230000945	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
243230000946	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
243230000947	active site
243230000948	FMN binding site [chemical binding]; other site
243230000949	substrate binding site [chemical binding]; other site
243230000950	3Fe-4S cluster binding site [ion binding]; other site
243230000951	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
243230000952	domain interface; other site
243230000953	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
243230000954	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
243230000955	substrate binding site [chemical binding]; other site
243230000956	oxyanion hole (OAH) forming residues; other site
243230000957	trimer interface [polypeptide binding]; other site
243230000958	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
243230000959	Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570
243230000960	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
243230000961	generic binding surface II; other site
243230000962	generic binding surface I; other site
243230000963	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
243230000964	putative active site [active]
243230000965	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
243230000966	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230000967	Coenzyme A binding pocket [chemical binding]; other site
243230000968	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
243230000969	catalytic residues [active]
243230000970	Peptidase family M48; Region: Peptidase_M48; pfam01435
243230000971	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
243230000972	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
243230000973	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
243230000974	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
243230000975	nudix motif; other site
243230000976	Uncharacterized conserved protein [Function unknown]; Region: COG2383
243230000977	Predicted Zn-dependent protease [General function prediction only]; Region: COG2738
243230000978	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
243230000979	homodimer interface [polypeptide binding]; other site
243230000980	substrate-cofactor binding pocket; other site
243230000981	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243230000982	catalytic residue [active]
243230000983	anthranilate synthase component I, archaeal clade; Region: TrpE-arch; TIGR01820
243230000984	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
243230000985	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
243230000986	Glutamine amidotransferase class-I; Region: GATase; pfam00117
243230000987	glutamine binding [chemical binding]; other site
243230000988	catalytic triad [active]
243230000989	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
243230000990	recombination protein RecR; Reviewed; Region: recR; PRK00076
243230000991	RecR protein; Region: RecR; pfam02132
243230000992	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
243230000993	putative active site [active]
243230000994	putative metal-binding site [ion binding]; other site
243230000995	tetramer interface [polypeptide binding]; other site
243230000996	hypothetical protein; Validated; Region: PRK00153
243230000997	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
243230000998	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
243230000999	putative DNA binding site [nucleotide binding]; other site
243230001000	putative Zn2+ binding site [ion binding]; other site
243230001001	AsnC family; Region: AsnC_trans_reg; pfam01037
243230001002	Uncharacterized conserved protein [Function unknown]; Region: COG5403
243230001003	AAA domain; Region: AAA_17; cl19128
243230001004	Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563
243230001005	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
243230001006	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
243230001007	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694
243230001008	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
243230001009	ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267
243230001010	Walker A/P-loop; other site
243230001011	ATP binding site [chemical binding]; other site
243230001012	Q-loop/lid; other site
243230001013	ABC transporter signature motif; other site
243230001014	Walker B; other site
243230001015	D-loop; other site
243230001016	H-loop/switch region; other site
243230001017	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
243230001018	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
243230001019	Glucose inhibited division protein A; Region: GIDA; pfam01134
243230001020	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
243230001021	putative active site [active]
243230001022	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
243230001023	Mechanosensitive ion channel; Region: MS_channel; pfam00924
243230001024	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230001025	Coenzyme A binding pocket [chemical binding]; other site
243230001026	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
243230001027	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
243230001028	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
243230001029	catalytic residue [active]
243230001030	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
243230001031	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
243230001032	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
243230001033	active site residue [active]
243230001034	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
243230001035	active site residue [active]
243230001036	amidophosphoribosyltransferase; Region: purF; TIGR01134
243230001037	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
243230001038	active site
243230001039	tetramer interface [polypeptide binding]; other site
243230001040	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
243230001041	active site
243230001042	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
243230001043	putative active site [active]
243230001044	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
243230001045	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
243230001046	dimerization interface [polypeptide binding]; other site
243230001047	ATP binding site [chemical binding]; other site
243230001048	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
243230001049	dimerization interface [polypeptide binding]; other site
243230001050	ATP binding site [chemical binding]; other site
243230001051	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
243230001052	putative active site [active]
243230001053	catalytic triad [active]
243230001054	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
243230001055	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
243230001056	active site
243230001057	ATP binding site [chemical binding]; other site
243230001058	substrate binding site [chemical binding]; other site
243230001059	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
243230001060	Uncharacterized protein affecting Mg2+/Co2+ transport [Inorganic ion transport and metabolism]; Region: ApaG; COG2967
243230001061	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
243230001062	oligomer interface [polypeptide binding]; other site
243230001063	active site
243230001064	metal binding site [ion binding]; metal-binding site
243230001065	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
243230001066	homotrimer interaction site [polypeptide binding]; other site
243230001067	zinc binding site [ion binding]; other site
243230001068	CDP-binding sites; other site
243230001069	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
243230001070	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
243230001071	putative DNA binding site [nucleotide binding]; other site
243230001072	putative Zn2+ binding site [ion binding]; other site
243230001073	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3860
243230001074	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
243230001075	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
243230001076	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
243230001077	active site
243230001078	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
243230001079	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
243230001080	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
243230001081	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502
243230001082	arginine decarboxylase; Provisional; Region: PRK05354
243230001083	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
243230001084	dimer interface [polypeptide binding]; other site
243230001085	active site
243230001086	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
243230001087	catalytic residues [active]
243230001088	substrate binding site [chemical binding]; other site
243230001089	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
243230001090	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230001091	Coenzyme A binding pocket [chemical binding]; other site
243230001092	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
243230001093	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243230001094	S-adenosylmethionine binding site [chemical binding]; other site
243230001095	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
243230001096	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
243230001097	G-X-X-G motif; other site
243230001098	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
243230001099	RxxxH motif; other site
243230001100	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK14662
243230001101	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
243230001102	active site
243230001103	NTP binding site [chemical binding]; other site
243230001104	metal binding triad [ion binding]; metal-binding site
243230001105	antibiotic binding site [chemical binding]; other site
243230001106	Uncharacterized conserved protein [Function unknown]; Region: COG2361
243230001107	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
243230001108	active site
243230001109	catalytic tetrad [active]
243230001110	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
243230001111	TM-ABC transporter signature motif; other site
243230001112	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
243230001113	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
243230001114	interrupted 23S ribosomal RNA
243230001115	DDE superfamily endonuclease; Region: DDE_3; pfam13358
243230001116	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_long; TIGR01348
243230001117	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
243230001118	E3 interaction surface; other site
243230001119	lipoyl attachment site [posttranslational modification]; other site
243230001120	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
243230001121	E3 interaction surface; other site
243230001122	lipoyl attachment site [posttranslational modification]; other site
243230001123	e3 binding domain; Region: E3_binding; pfam02817
243230001124	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
243230001125	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
243230001126	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
243230001127	dimer interface [polypeptide binding]; other site
243230001128	TPP-binding site [chemical binding]; other site
243230001129	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
243230001130	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243230001131	Major Facilitator Superfamily; Region: MFS_1; pfam07690
243230001132	putative substrate translocation pore; other site
243230001133	Transcriptional regulators [Transcription]; Region: MarR; COG1846
243230001134	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
243230001135	putative DNA binding site [nucleotide binding]; other site
243230001136	dimerization interface [polypeptide binding]; other site
243230001137	putative Zn2+ binding site [ion binding]; other site
243230001138	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
243230001139	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243230001140	putative substrate translocation pore; other site
243230001141	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
243230001142	nudix motif; other site
243230001143	ABC transporter periplasmic binding protein, thiB subfamily; Region: sfuA; TIGR01254
243230001144	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
243230001145	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
243230001146	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
243230001147	active site
243230001148	catalytic site [active]
243230001149	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
243230001150	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
243230001151	DNA-binding site [nucleotide binding]; DNA binding site
243230001152	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
243230001153	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243230001154	Radical SAM superfamily; Region: Radical_SAM; pfam04055
243230001155	FeS/SAM binding site; other site
243230001156	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
243230001157	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243230001158	metal binding site [ion binding]; metal-binding site
243230001159	active site
243230001160	I-site; other site
243230001161	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
243230001162	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
243230001163	ribonuclease Z; Provisional; Region: PRK02126
243230001164	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
243230001165	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
243230001166	MOSC domain; Region: MOSC; pfam03473
243230001167	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_27; cd04686
243230001168	nudix motif; other site
243230001169	Predicted membrane protein [Function unknown]; Region: COG2862
243230001170	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
243230001171	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
243230001172	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
243230001173	catalytic core [active]
243230001174	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
243230001175	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336
243230001176	putative ligand binding site [chemical binding]; other site
243230001177	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
243230001178	TM-ABC transporter signature motif; other site
243230001179	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
243230001180	TM-ABC transporter signature motif; other site
243230001181	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
243230001182	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
243230001183	Walker A/P-loop; other site
243230001184	ATP binding site [chemical binding]; other site
243230001185	Q-loop/lid; other site
243230001186	ABC transporter signature motif; other site
243230001187	Walker B; other site
243230001188	D-loop; other site
243230001189	H-loop/switch region; other site
243230001190	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
243230001191	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
243230001192	Walker A/P-loop; other site
243230001193	ATP binding site [chemical binding]; other site
243230001194	Q-loop/lid; other site
243230001195	ABC transporter signature motif; other site
243230001196	Walker B; other site
243230001197	D-loop; other site
243230001198	H-loop/switch region; other site
243230001199	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
243230001200	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
243230001201	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
243230001202	TPP-binding site [chemical binding]; other site
243230001203	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
243230001204	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
243230001205	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
243230001206	minor groove reading motif; other site
243230001207	helix-hairpin-helix signature motif; other site
243230001208	substrate binding pocket [chemical binding]; other site
243230001209	active site
243230001210	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
243230001211	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243230001212	Major Facilitator Superfamily; Region: MFS_1; pfam07690
243230001213	putative substrate translocation pore; other site
243230001214	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
243230001215	Putative zinc ribbon domain; Region: DUF164; pfam02591
243230001216	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
243230001217	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
243230001218	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243230001219	motif II; other site
243230001220	putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198
243230001221	pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569
243230001222	active site
243230001223	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
243230001224	active site
243230001225	metal binding site [ion binding]; metal-binding site
243230001226	UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085
243230001227	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
243230001228	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
243230001229	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
243230001230	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
243230001231	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
243230001232	Substrate-binding site [chemical binding]; other site
243230001233	Substrate specificity [chemical binding]; other site
243230001234	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
243230001235	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
243230001236	Substrate-binding site [chemical binding]; other site
243230001237	Substrate specificity [chemical binding]; other site
243230001238	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
243230001239	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
243230001240	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331
243230001241	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
243230001242	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
243230001243	glutaminase active site [active]
243230001244	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
243230001245	dimer interface [polypeptide binding]; other site
243230001246	active site
243230001247	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
243230001248	dimer interface [polypeptide binding]; other site
243230001249	active site
243230001250	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
243230001251	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
243230001252	S17 interaction site [polypeptide binding]; other site
243230001253	S8 interaction site; other site
243230001254	16S rRNA interaction site [nucleotide binding]; other site
243230001255	streptomycin interaction site [chemical binding]; other site
243230001256	23S rRNA interaction site [nucleotide binding]; other site
243230001257	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
243230001258	30S ribosomal protein S7; Validated; Region: PRK05302
243230001259	elongation factor G; Reviewed; Region: PRK00007
243230001260	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
243230001261	G1 box; other site
243230001262	putative GEF interaction site [polypeptide binding]; other site
243230001263	GTP/Mg2+ binding site [chemical binding]; other site
243230001264	Switch I region; other site
243230001265	G2 box; other site
243230001266	G3 box; other site
243230001267	Switch II region; other site
243230001268	G4 box; other site
243230001269	G5 box; other site
243230001270	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
243230001271	Elongation Factor G, domain II; Region: EFG_II; pfam14492
243230001272	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
243230001273	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
243230001274	elongation factor Tu; Reviewed; Region: PRK00049
243230001275	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
243230001276	G1 box; other site
243230001277	GEF interaction site [polypeptide binding]; other site
243230001278	GTP/Mg2+ binding site [chemical binding]; other site
243230001279	Switch I region; other site
243230001280	G2 box; other site
243230001281	G3 box; other site
243230001282	Switch II region; other site
243230001283	G4 box; other site
243230001284	G5 box; other site
243230001285	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
243230001286	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
243230001287	Antibiotic Binding Site [chemical binding]; other site
243230001288	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
243230001289	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
243230001290	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
243230001291	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
243230001292	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
243230001293	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
243230001294	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
243230001295	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
243230001296	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
243230001297	putative translocon binding site; other site
243230001298	protein-rRNA interface [nucleotide binding]; other site
243230001299	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
243230001300	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
243230001301	G-X-X-G motif; other site
243230001302	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
243230001303	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
243230001304	23S rRNA interface [nucleotide binding]; other site
243230001305	5S rRNA interface [nucleotide binding]; other site
243230001306	putative antibiotic binding site [chemical binding]; other site
243230001307	L25 interface [polypeptide binding]; other site
243230001308	L27 interface [polypeptide binding]; other site
243230001309	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
243230001310	23S rRNA interface [nucleotide binding]; other site
243230001311	putative translocon interaction site; other site
243230001312	signal recognition particle (SRP54) interaction site; other site
243230001313	L23 interface [polypeptide binding]; other site
243230001314	trigger factor interaction site; other site
243230001315	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
243230001316	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
243230001317	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
243230001318	RNA binding site [nucleotide binding]; other site
243230001319	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
243230001320	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
243230001321	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
243230001322	Methenyl tetrahydrofolate cyclohydrolase [Amino acid transport and metabolism]; Region: COG3404
243230001323	malate dehydrogenase; Provisional; Region: PRK05442
243230001324	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
243230001325	NAD(P) binding site [chemical binding]; other site
243230001326	dimer interface [polypeptide binding]; other site
243230001327	malate binding site [chemical binding]; other site
243230001328	crystallin beta/gamma motif-containing protein; Region: PHA00657
243230001329	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
243230001330	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
243230001331	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
243230001332	protein binding site [polypeptide binding]; other site
243230001333	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
243230001334	putative active site pocket [active]
243230001335	dimerization interface [polypeptide binding]; other site
243230001336	putative catalytic residue [active]
243230001337	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
243230001338	nudix motif; other site
243230001339	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680
243230001340	nudix motif; other site
243230001341	menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701
243230001342	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
243230001343	Domain of unknown function (DUF3885); Region: DUF3885; pfam13021
243230001344	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
243230001345	DEAD-like helicases superfamily; Region: DEXDc; smart00487
243230001346	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
243230001347	ATP binding site [chemical binding]; other site
243230001348	putative Mg++ binding site [ion binding]; other site
243230001349	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243230001350	nucleotide binding region [chemical binding]; other site
243230001351	ATP-binding site [chemical binding]; other site
243230001352	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
243230001353	acyl-CoA synthetase; Validated; Region: PRK08162
243230001354	acyl-activating enzyme (AAE) consensus motif; other site
243230001355	putative active site [active]
243230001356	AMP binding site [chemical binding]; other site
243230001357	putative CoA binding site [chemical binding]; other site
243230001358	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
243230001359	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
243230001360	metal binding site [ion binding]; metal-binding site
243230001361	dimer interface [polypeptide binding]; other site
243230001362	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
243230001363	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
243230001364	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
243230001365	16S/18S rRNA binding site [nucleotide binding]; other site
243230001366	S13e-L30e interaction site [polypeptide binding]; other site
243230001367	25S rRNA binding site [nucleotide binding]; other site
243230001368	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
243230001369	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
243230001370	iron-sulfur cluster [ion binding]; other site
243230001371	[2Fe-2S] cluster binding site [ion binding]; other site
243230001372	TPR repeat; Region: TPR_11; pfam13414
243230001373	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243230001374	TPR motif; other site
243230001375	binding surface
243230001376	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
243230001377	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
243230001378	Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088
243230001379	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
243230001380	catalytic residues [active]
243230001381	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
243230001382	Cytochrome c-type biogenesis protein CcmE [Posttranslational modification, protein turnover, chaperones]; Region: CcmE; COG2332
243230001383	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
243230001384	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
243230001385	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
243230001386	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
243230001387	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243230001388	Walker A motif; other site
243230001389	ATP binding site [chemical binding]; other site
243230001390	Walker B motif; other site
243230001391	arginine finger; other site
243230001392	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
243230001393	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
243230001394	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
243230001395	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
243230001396	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
243230001397	Predicted membrane protein [Function unknown]; Region: COG4291
243230001398	Exoribonuclease R [Transcription]; Region: VacB; COG0557
243230001399	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
243230001400	RNB domain; Region: RNB; pfam00773
243230001401	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
243230001402	RNA binding site [nucleotide binding]; other site
243230001403	Exonuclease III [DNA replication, recombination, and repair]; Region: XthA; COG0708
243230001404	putative catalytic site [active]
243230001405	putative metal binding site [ion binding]; other site
243230001406	putative phosphate binding site [ion binding]; other site
243230001407	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243230001408	Putative transcriptional regulator [Transcription]; Region: COG1678
243230001409	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
243230001410	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
243230001411	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
243230001412	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
243230001413	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
243230001414	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
243230001415	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
243230001416	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
243230001417	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
243230001418	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
243230001419	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
243230001420	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
243230001421	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
243230001422	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243230001423	dimer interface [polypeptide binding]; other site
243230001424	conserved gate region; other site
243230001425	putative PBP binding loops; other site
243230001426	ABC-ATPase subunit interface; other site
243230001427	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
243230001428	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
243230001429	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243230001430	dimer interface [polypeptide binding]; other site
243230001431	conserved gate region; other site
243230001432	putative PBP binding loops; other site
243230001433	ABC-ATPase subunit interface; other site
243230001434	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
243230001435	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243230001436	FeS/SAM binding site; other site
243230001437	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
243230001438	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230001439	Coenzyme A binding pocket [chemical binding]; other site
243230001440	Uncharacterized conserved protein [Function unknown]; Region: COG2013
243230001441	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
243230001442	Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427
243230001443	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
243230001444	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
243230001445	dimer interface [polypeptide binding]; other site
243230001446	putative anticodon binding site; other site
243230001447	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
243230001448	motif 1; other site
243230001449	active site
243230001450	motif 2; other site
243230001451	motif 3; other site
243230001452	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
243230001453	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
243230001454	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
243230001455	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
243230001456	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
243230001457	putative active site [active]
243230001458	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
243230001459	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
243230001460	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243230001461	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
243230001462	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
243230001463	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
243230001464	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
243230001465	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
243230001466	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
243230001467	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
243230001468	Surface antigen; Region: Bac_surface_Ag; pfam01103
243230001469	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
243230001470	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
243230001471	tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723
243230001472	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
243230001473	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
243230001474	Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
243230001475	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
243230001476	1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612
243230001477	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4296
243230001478	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
243230001479	Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
243230001480	DAK2 domain; Region: Dak2; pfam02734
243230001481	Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684
243230001482	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
243230001483	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
243230001484	BON domain; Region: BON; pfam04972
243230001485	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
243230001486	elongation factor G; Reviewed; Region: PRK12740
243230001487	G1 box; other site
243230001488	putative GEF interaction site [polypeptide binding]; other site
243230001489	GTP/Mg2+ binding site [chemical binding]; other site
243230001490	Switch I region; other site
243230001491	G2 box; other site
243230001492	G3 box; other site
243230001493	Switch II region; other site
243230001494	G4 box; other site
243230001495	G5 box; other site
243230001496	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
243230001497	Elongation Factor G, domain II; Region: EFG_II; pfam14492
243230001498	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
243230001499	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
243230001500	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
243230001501	Phosphotransferase enzyme family; Region: APH; pfam01636
243230001502	active site
243230001503	ATP binding site [chemical binding]; other site
243230001504	substrate binding site [chemical binding]; other site
243230001505	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
243230001506	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243230001507	putative substrate translocation pore; other site
243230001508	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
243230001509	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
243230001510	putative [4Fe-4S] binding site [ion binding]; other site
243230001511	putative molybdopterin cofactor binding site [chemical binding]; other site
243230001512	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
243230001513	putative molybdopterin cofactor binding site; other site
243230001514	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
243230001515	Fasciclin domain; Region: Fasciclin; pfam02469
243230001516	Fasciclin domain; Region: Fasciclin; pfam02469
243230001517	Fasciclin domain; Region: Fasciclin; pfam02469
243230001518	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
243230001519	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
243230001520	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
243230001521	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
243230001522	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
243230001523	MPN+ (JAMM) motif; other site
243230001524	Zinc-binding site [ion binding]; other site
243230001525	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
243230001526	active site
243230001527	tetramer interface [polypeptide binding]; other site
243230001528	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cl04227
243230001529	carbohydrate binding site [chemical binding]; other site
243230001530	alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103
243230001531	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
243230001532	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
243230001533	Ca binding site [ion binding]; other site
243230001534	active site
243230001535	catalytic site [active]
243230001536	Domain of unknown function (DUF3372); Region: DUF3372; pfam11852
243230001537	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
243230001538	ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133
243230001539	Walker A/P-loop; other site
243230001540	ATP binding site [chemical binding]; other site
243230001541	Q-loop/lid; other site
243230001542	ABC transporter signature motif; other site
243230001543	Walker B; other site
243230001544	D-loop; other site
243230001545	H-loop/switch region; other site
243230001546	ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386
243230001547	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
243230001548	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243230001549	active site
243230001550	phosphorylation site [posttranslational modification]
243230001551	intermolecular recognition site; other site
243230001552	dimerization interface [polypeptide binding]; other site
243230001553	DinB superfamily; Region: DinB_2; pfam12867
243230001554	Inorganic pyrophosphatase [Energy production and conversion]; Region: Ppa; COG0221
243230001555	short chain dehydrogenase; Provisional; Region: PRK08219
243230001556	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243230001557	NAD(P) binding site [chemical binding]; other site
243230001558	active site
243230001559	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
243230001560	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
243230001561	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
243230001562	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243230001563	motif II; other site
243230001564	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
243230001565	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
243230001566	substrate binding pocket [chemical binding]; other site
243230001567	catalytic triad [active]
243230001568	Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336
243230001569	PemK-like protein; Region: PemK; cl00995
243230001570	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875
243230001571	putative active site [active]
243230001572	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
243230001573	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
243230001574	ATP binding site [chemical binding]; other site
243230001575	putative Mg++ binding site [ion binding]; other site
243230001576	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243230001577	nucleotide binding region [chemical binding]; other site
243230001578	ATP-binding site [chemical binding]; other site
243230001579	Helicase associated domain (HA2); Region: HA2; pfam04408
243230001580	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
243230001581	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
243230001582	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243230001583	S-adenosylmethionine binding site [chemical binding]; other site
243230001584	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4712
243230001585	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
243230001586	putative active site pocket [active]
243230001587	4-fold oligomerization interface [polypeptide binding]; other site
243230001588	metal binding residues [ion binding]; metal-binding site
243230001589	3-fold/trimer interface [polypeptide binding]; other site
243230001590	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
243230001591	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142
243230001592	putative active site [active]
243230001593	oxyanion strand; other site
243230001594	catalytic triad [active]
243230001595	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
243230001596	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
243230001597	5S rRNA interface [nucleotide binding]; other site
243230001598	CTC domain interface [polypeptide binding]; other site
243230001599	L16 interface [polypeptide binding]; other site
243230001600	Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693
243230001601	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
243230001602	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
243230001603	DNA binding site [nucleotide binding]
243230001604	active site
243230001605	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
243230001606	Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690
243230001607	tRNA-splicing ligase RtcB; Region: RtcB; pfam01139
243230001608	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243230001609	S-adenosylmethionine binding site [chemical binding]; other site
243230001610	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
243230001611	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243230001612	active site
243230001613	phosphorylation site [posttranslational modification]
243230001614	intermolecular recognition site; other site
243230001615	dimerization interface [polypeptide binding]; other site
243230001616	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
243230001617	DNA binding residues [nucleotide binding]
243230001618	dimerization interface [polypeptide binding]; other site
243230001619	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
243230001620	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
243230001621	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
243230001622	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
243230001623	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
243230001624	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
243230001625	iron-sulfur cluster [ion binding]; other site
243230001626	[2Fe-2S] cluster binding site [ion binding]; other site
243230001627	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
243230001628	intrachain domain interface; other site
243230001629	heme bL binding site [chemical binding]; other site
243230001630	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
243230001631	heme bH binding site [chemical binding]; other site
243230001632	Qo binding site; other site
243230001633	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
243230001634	intrachain domain interface; other site
243230001635	Qo binding site; other site
243230001636	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
243230001637	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280
243230001638	active site
243230001639	putative DNA-binding cleft [nucleotide binding]; other site
243230001640	dimer interface [polypeptide binding]; other site
243230001641	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
243230001642	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
243230001643	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
243230001644	Walker A motif; other site
243230001645	ATP binding site [chemical binding]; other site
243230001646	Walker B motif; other site
243230001647	Thymidine phosphorylase [Nucleotide transport and metabolism]; Region: DeoA; COG0213
243230001648	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
243230001649	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
243230001650	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
243230001651	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
243230001652	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
243230001653	putative ADP-binding pocket [chemical binding]; other site
243230001654	Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504
243230001655	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
243230001656	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
243230001657	active site
243230001658	Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530
243230001659	non-specific DNA binding site [nucleotide binding]; other site
243230001660	salt bridge; other site
243230001661	sequence-specific DNA binding site [nucleotide binding]; other site
243230001662	Ribonuclease H-like superfamily, including RNase H, HI, HII, HIII, and RNase-like domain IV of spliceosomal protein Prp8; Region: RNase_H_like; cl14782
243230001663	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
243230001664	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
243230001665	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
243230001666	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
243230001667	Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141
243230001668	putative RNAase interaction site [polypeptide binding]; other site
243230001669	RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607
243230001670	active site
243230001671	barstar interaction site; other site
243230001672	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
243230001673	Streptomycin 6-kinase [Defense mechanisms]; Region: StrB; COG3570
243230001674	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
243230001675	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
243230001676	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951
243230001677	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003
243230001678	acetyl-CoA synthetase; Provisional; Region: PRK00174
243230001679	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
243230001680	acyl-activating enzyme (AAE) consensus motif; other site
243230001681	AMP binding site [chemical binding]; other site
243230001682	active site
243230001683	CoA binding site [chemical binding]; other site
243230001684	pantothenate kinase; Reviewed; Region: PRK13318
243230001685	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
243230001686	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
243230001687	cobalamin binding residues [chemical binding]; other site
243230001688	putative BtuC binding residues; other site
243230001689	dimer interface [polypeptide binding]; other site
243230001690	Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280
243230001691	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
243230001692	active site
243230001693	catalytic site [active]
243230001694	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
243230001695	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
243230001696	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
243230001697	catalytic site [active]
243230001698	active site
243230001699	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
243230001700	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
243230001701	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
243230001702	PAS fold; Region: PAS_4; pfam08448
243230001703	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243230001704	putative active site [active]
243230001705	heme pocket [chemical binding]; other site
243230001706	PAS fold; Region: PAS_4; pfam08448
243230001707	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
243230001708	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243230001709	metal binding site [ion binding]; metal-binding site
243230001710	active site
243230001711	I-site; other site
243230001712	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243230001713	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
243230001714	hypothetical protein; Provisional; Region: PRK08609
243230001715	active site
243230001716	primer binding site [nucleotide binding]; other site
243230001717	NTP  binding site [chemical binding]; other site
243230001718	metal binding triad [ion binding]; metal-binding site
243230001719	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
243230001720	active site
243230001721	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
243230001722	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
243230001723	putative active site [active]
243230001724	histidinol-phosphatase; Provisional; Region: PRK07328
243230001725	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
243230001726	active site
243230001727	dimer interface [polypeptide binding]; other site
243230001728	TIGR00730 family protein; Region: TIGR00730
243230001729	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243230001730	Major Facilitator Superfamily; Region: MFS_1; pfam07690
243230001731	putative substrate translocation pore; other site
243230001732	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
243230001733	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
243230001734	Walker A/P-loop; other site
243230001735	ATP binding site [chemical binding]; other site
243230001736	Q-loop/lid; other site
243230001737	ABC transporter signature motif; other site
243230001738	Walker B; other site
243230001739	D-loop; other site
243230001740	H-loop/switch region; other site
243230001741	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
243230001742	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
243230001743	FtsX-like permease family; Region: FtsX; pfam02687
243230001744	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
243230001745	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
243230001746	ABC transporter; Region: ABC_tran_2; pfam12848
243230001747	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
243230001748	Predicted membrane protein [Function unknown]; Region: COG3162
243230001749	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
243230001750	Na binding site [ion binding]; other site
243230001751	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
243230001752	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
243230001753	active site
243230001754	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
243230001755	Transglycosylase; Region: Transgly; pfam00912
243230001756	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
243230001757	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
243230001758	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
243230001759	Ligand Binding Site [chemical binding]; other site
243230001760	TIGR00269 family protein; Region: TIGR00269
243230001761	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
243230001762	Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_prohibitin; cd03401
243230001763	SEC-C motif; Region: SEC-C; cl19389
243230001764	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012
243230001765	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
243230001766	Sel1 repeat; Region: Sel1; pfam08238
243230001767	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
243230001768	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
243230001769	active site
243230001770	HIGH motif; other site
243230001771	KMSKS motif; other site
243230001772	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
243230001773	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
243230001774	FtsX-like permease family; Region: FtsX; pfam02687
243230001775	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
243230001776	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
243230001777	putative substrate binding pocket [chemical binding]; other site
243230001778	AC domain interface; other site
243230001779	catalytic triad [active]
243230001780	AB domain interface; other site
243230001781	interchain disulfide; other site
243230001782	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
243230001783	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
243230001784	potential catalytic triad [active]
243230001785	conserved cys residue [active]
243230001786	Uncharacterized conserved protein [Function unknown]; Region: COG1359
243230001787	formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK14811
243230001788	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
243230001789	DNA binding site [nucleotide binding]
243230001790	catalytic residue [active]
243230001791	H2TH interface [polypeptide binding]; other site
243230001792	putative catalytic residues [active]
243230001793	turnover-facilitating residue; other site
243230001794	intercalation triad [nucleotide binding]; other site
243230001795	8OG recognition residue [nucleotide binding]; other site
243230001796	putative reading head residues; other site
243230001797	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
243230001798	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
243230001799	AAA domain; Region: AAA_17; cl19128
243230001800	Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563
243230001801	Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259
243230001802	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
243230001803	Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590
243230001804	ferredoxin-NADP+ reductase; Region: PLN02852
243230001805	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
243230001806	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
243230001807	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
243230001808	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
243230001809	putative L-serine binding site [chemical binding]; other site
243230001810	integral membrane protein MviN; Region: mviN; TIGR01695
243230001811	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
243230001812	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
243230001813	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
243230001814	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833
243230001815	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
243230001816	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
243230001817	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
243230001818	quinone interaction residues [chemical binding]; other site
243230001819	active site
243230001820	catalytic residues [active]
243230001821	FMN binding site [chemical binding]; other site
243230001822	substrate binding site [chemical binding]; other site
243230001823	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
243230001824	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
243230001825	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
243230001826	DHHA1 domain; Region: DHHA1; pfam02272
243230001827	FOG: WD40-like repeat [Function unknown]; Region: COG1520
243230001828	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
243230001829	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
243230001830	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
243230001831	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
243230001832	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243230001833	S-adenosylmethionine binding site [chemical binding]; other site
243230001834	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
243230001835	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
243230001836	putative active site [active]
243230001837	putative metal binding site [ion binding]; other site
243230001838	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
243230001839	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
243230001840	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
243230001841	active site
243230001842	PHP Thumb interface [polypeptide binding]; other site
243230001843	metal binding site [ion binding]; metal-binding site
243230001844	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
243230001845	Helix-hairpin-helix motif; Region: HHH_6; pfam14579
243230001846	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
243230001847	generic binding surface II; other site
243230001848	generic binding surface I; other site
243230001849	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
243230001850	Mrr N-terminal domain; Region: Mrr_N; pfam14338
243230001851	Restriction endonuclease; Region: Mrr_cat; pfam04471
243230001852	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243230001853	PAS domain; Region: PAS_9; pfam13426
243230001854	putative active site [active]
243230001855	heme pocket [chemical binding]; other site
243230001856	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
243230001857	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243230001858	Walker A/P-loop; other site
243230001859	ATP binding site [chemical binding]; other site
243230001860	Q-loop/lid; other site
243230001861	ABC transporter signature motif; other site
243230001862	Walker B; other site
243230001863	D-loop; other site
243230001864	H-loop/switch region; other site
243230001865	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
243230001866	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243230001867	dimer interface [polypeptide binding]; other site
243230001868	conserved gate region; other site
243230001869	putative PBP binding loops; other site
243230001870	ABC-ATPase subunit interface; other site
243230001871	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
243230001872	EamA-like transporter family; Region: EamA; pfam00892
243230001873	EamA-like transporter family; Region: EamA; pfam00892
243230001874	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
243230001875	Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659
243230001876	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
243230001877	active site
243230001878	DNA binding site [nucleotide binding]
243230001879	Int/Topo IB signature motif; other site
243230001880	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
243230001881	non-specific DNA binding site [nucleotide binding]; other site
243230001882	salt bridge; other site
243230001883	sequence-specific DNA binding site [nucleotide binding]; other site
243230001884	anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748
243230001885	TRAP binding interface [polypeptide binding]; other site
243230001886	Zn binding site [ion binding]; other site
243230001887	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
243230001888	polymerase nucleotide-binding site; other site
243230001889	DNA-binding residues [nucleotide binding]; DNA binding site
243230001890	nucleotide binding site [chemical binding]; other site
243230001891	primase nucleotide-binding site [nucleotide binding]; other site
243230001892	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
243230001893	Helix-turn-helix domain; Region: HTH_17; pfam12728
243230001894	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
243230001895	active site
243230001896	ATP binding site [chemical binding]; other site
243230001897	substrate binding site [chemical binding]; other site
243230001898	activation loop (A-loop); other site
243230001899	OmpA family; Region: OmpA; pfam00691
243230001900	ligand binding site [chemical binding]; other site
243230001901	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
243230001902	Tubulin like; Region: Tubulin_2; pfam13809
243230001903	Uncharacterized conserved protein [Function unknown]; Region: COG1801
243230001904	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
243230001905	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
243230001906	active site
243230001907	catalytic site [active]
243230001908	metal binding site [ion binding]; metal-binding site
243230001909	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
243230001910	classical (c) SDRs; Region: SDR_c; cd05233
243230001911	NAD(P) binding site [chemical binding]; other site
243230001912	active site
243230001913	Predicted permeases [General function prediction only]; Region: COG0730
243230001914	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
243230001915	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
243230001916	Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; pfam05090
243230001917	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
243230001918	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
243230001919	replicative DNA helicase; Region: DnaB; TIGR00665
243230001920	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
243230001921	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
243230001922	Walker A motif; other site
243230001923	ATP binding site [chemical binding]; other site
243230001924	Walker B motif; other site
243230001925	DNA binding loops [nucleotide binding]
243230001926	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
243230001927	nudix motif; other site
243230001928	acyl-coenzyme A oxidase; Region: PLN02526
243230001929	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
243230001930	active site
243230001931	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
243230001932	Thiamine pyrophosphokinase; Region: TPK; cd07995
243230001933	active site
243230001934	dimerization interface [polypeptide binding]; other site
243230001935	thiamine binding site [chemical binding]; other site
243230001936	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
243230001937	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
243230001938	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
243230001939	inhibitor-cofactor binding pocket; inhibition site
243230001940	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243230001941	catalytic residue [active]
243230001942	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
243230001943	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
243230001944	tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927
243230001945	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
243230001946	active site
243230001947	HIGH motif; other site
243230001948	dimer interface [polypeptide binding]; other site
243230001949	KMSKS motif; other site
243230001950	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
243230001951	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
243230001952	Domain of unknown function (DUF814); Region: DUF814; pfam05670
243230001953	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
243230001954	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
243230001955	catalytic residues [active]
243230001956	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
243230001957	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
243230001958	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243230001959	dimer interface [polypeptide binding]; other site
243230001960	conserved gate region; other site
243230001961	putative PBP binding loops; other site
243230001962	ABC-ATPase subunit interface; other site
243230001963	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
243230001964	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243230001965	dimer interface [polypeptide binding]; other site
243230001966	conserved gate region; other site
243230001967	putative PBP binding loops; other site
243230001968	ABC-ATPase subunit interface; other site
243230001969	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243230001970	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243230001971	substrate binding pocket [chemical binding]; other site
243230001972	membrane-bound complex binding site; other site
243230001973	hinge residues; other site
243230001974	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
243230001975	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243230001976	dimer interface [polypeptide binding]; other site
243230001977	conserved gate region; other site
243230001978	putative PBP binding loops; other site
243230001979	ABC-ATPase subunit interface; other site
243230001980	Uncharacterized conserved protein [Function unknown]; Region: COG2947
243230001981	threonine dehydratase; Reviewed; Region: PRK09224
243230001982	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
243230001983	tetramer interface [polypeptide binding]; other site
243230001984	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243230001985	catalytic residue [active]
243230001986	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
243230001987	putative Ile/Val binding site [chemical binding]; other site
243230001988	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
243230001989	putative Ile/Val binding site [chemical binding]; other site
243230001990	adenine phosphoribosyltransferase; Provisional; Region: PRK07322
243230001991	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: PspE; COG0607
243230001992	active site residue [active]
243230001993	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
243230001994	Predicted dehydrogenase [General function prediction only]; Region: COG0579
243230001995	Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385
243230001996	Stage II sporulation protein; Region: SpoIID; pfam08486
243230001997	large tegument protein UL36; Provisional; Region: PHA03247
243230001998	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323
243230001999	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906
243230002000	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
243230002001	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243230002002	nucleotide binding region [chemical binding]; other site
243230002003	SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516
243230002004	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
243230002005	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
243230002006	GAF domain; Region: GAF_3; pfam13492
243230002007	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
243230002008	Histidine kinase; Region: HisKA_3; pfam07730
243230002009	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243230002010	ATP binding site [chemical binding]; other site
243230002011	Mg2+ binding site [ion binding]; other site
243230002012	G-X-G motif; other site
243230002013	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
243230002014	Flavoprotein; Region: Flavoprotein; cl19190
243230002015	DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127
243230002016	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
243230002017	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
243230002018	trimer interface [polypeptide binding]; other site
243230002019	active site
243230002020	substrate binding site [chemical binding]; other site
243230002021	CoA binding site [chemical binding]; other site
243230002022	DinB superfamily; Region: DinB_2; pfam12867
243230002023	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
243230002024	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243230002025	Walker A motif; other site
243230002026	ATP binding site [chemical binding]; other site
243230002027	Walker B motif; other site
243230002028	arginine finger; other site
243230002029	Peptidase family M41; Region: Peptidase_M41; pfam01434
243230002030	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
243230002031	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
243230002032	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
243230002033	putative active site [active]
243230002034	putative substrate binding site [chemical binding]; other site
243230002035	putative cosubstrate binding site; other site
243230002036	catalytic site [active]
243230002037	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
243230002038	Uncharacterized conserved protein [Function unknown]; Region: COG2127
243230002039	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
243230002040	Mrr N-terminal domain; Region: Mrr_N; pfam14338
243230002041	Restriction endonuclease; Region: Mrr_cat; pfam04471
243230002042	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
243230002043	Clp amino terminal domain; Region: Clp_N; pfam02861
243230002044	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243230002045	Walker A motif; other site
243230002046	ATP binding site [chemical binding]; other site
243230002047	Walker B motif; other site
243230002048	arginine finger; other site
243230002049	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243230002050	Walker A motif; other site
243230002051	ATP binding site [chemical binding]; other site
243230002052	Walker B motif; other site
243230002053	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
243230002054	Haemolytic domain; Region: Haemolytic; cl00506
243230002055	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
243230002056	Putative lysophospholipase; Region: Hydrolase_4; cl19140
243230002057	glycogen synthase; Provisional; Region: glgA; PRK00654
243230002058	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
243230002059	ADP-binding pocket [chemical binding]; other site
243230002060	homodimer interface [polypeptide binding]; other site
243230002061	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
243230002062	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243230002063	Walker A motif; other site
243230002064	ATP binding site [chemical binding]; other site
243230002065	Walker B motif; other site
243230002066	arginine finger; other site
243230002067	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
243230002068	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
243230002069	Cu(I) binding site [ion binding]; other site
243230002070	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
243230002071	Peptidase family M23; Region: Peptidase_M23; pfam01551
243230002072	Aminoglycoside N3'-acetyltransferase [Defense mechanisms]; Region: COG2746
243230002073	DNA primase; Validated; Region: dnaG; PRK05667
243230002074	CHC2 zinc finger; Region: zf-CHC2; cl17510
243230002075	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
243230002076	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
243230002077	active site
243230002078	metal binding site [ion binding]; metal-binding site
243230002079	interdomain interaction site; other site
243230002080	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
243230002081	catalytic core [active]
243230002082	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
243230002083	nucleoside/Zn binding site; other site
243230002084	dimer interface [polypeptide binding]; other site
243230002085	catalytic motif [active]
243230002086	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
243230002087	nudix motif; other site
243230002088	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243230002089	S-adenosylmethionine binding site [chemical binding]; other site
243230002090	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
243230002091	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230002092	Coenzyme A binding pocket [chemical binding]; other site
243230002093	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243230002094	metal binding site [ion binding]; metal-binding site
243230002095	active site
243230002096	I-site; other site
243230002097	Ribbon-helix-helix domain; Region: RHH_3; pfam12651
243230002098	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
243230002099	oligomerisation interface [polypeptide binding]; other site
243230002100	mobile loop; other site
243230002101	roof hairpin; other site
243230002102	chaperonin GroEL; Reviewed; Region: groEL; PRK12850
243230002103	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
243230002104	ring oligomerisation interface [polypeptide binding]; other site
243230002105	ATP/Mg binding site [chemical binding]; other site
243230002106	stacking interactions; other site
243230002107	hinge regions; other site
243230002108	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230002109	Coenzyme A binding pocket [chemical binding]; other site
243230002110	Predicted kinase [General function prediction only]; Region: COG0645
243230002111	AAA domain; Region: AAA_33; pfam13671
243230002112	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
243230002113	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
243230002114	Arginine degradation protein (predicted deacylase) [Amino acid transport and metabolism]; Region: RocB; COG4187
243230002115	Uncharacterized conserved protein [Function unknown]; Region: COG3665
243230002116	Uncharacterized conserved protein [Function unknown]; Region: COG3403
243230002117	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
243230002118	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243230002119	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
243230002120	dimerization interface [polypeptide binding]; other site
243230002121	substrate binding pocket [chemical binding]; other site
243230002122	Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018
243230002123	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
243230002124	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
243230002125	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
243230002126	Peptidase M16C associated; Region: M16C_assoc; pfam08367
243230002127	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
243230002128	Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590
243230002129	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
243230002130	Protein of unknown function DUF58; Region: DUF58; pfam01882
243230002131	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
243230002132	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
243230002133	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
243230002134	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
243230002135	MoxR-like ATPases [General function prediction only]; Region: COG0714
243230002136	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243230002137	Walker A motif; other site
243230002138	ATP binding site [chemical binding]; other site
243230002139	Walker B motif; other site
243230002140	arginine finger; other site
243230002141	aspartate aminotransferase; Provisional; Region: PRK05764
243230002142	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243230002143	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243230002144	homodimer interface [polypeptide binding]; other site
243230002145	catalytic residue [active]
243230002146	Predicted flavoprotein [General function prediction only]; Region: COG0431
243230002147	Uncharacterized conserved protein [Function unknown]; Region: COG2013
243230002148	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133
243230002149	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
243230002150	active site
243230002151	homodimer interface [polypeptide binding]; other site
243230002152	UDP-N-acetylmuramate--alanine ligase; Region: murC; TIGR01082
243230002153	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
243230002154	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
243230002155	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
243230002156	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14651
243230002157	FAD binding domain; Region: FAD_binding_4; cl19922
243230002158	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
243230002159	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
243230002160	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
243230002161	Cell division protein FtsQ; Region: FtsQ; pfam03799
243230002162	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
243230002163	Cell division protein FtsA; Region: FtsA; smart00842
243230002164	Cell division protein FtsA; Region: FtsA; pfam14450
243230002165	cell division protein FtsZ; Validated; Region: PRK09330
243230002166	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
243230002167	nucleotide binding site [chemical binding]; other site
243230002168	SulA interaction site; other site
243230002169	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3021
243230002170	putative catalytic site [active]
243230002171	putative metal binding site [ion binding]; other site
243230002172	putative phosphate binding site [ion binding]; other site
243230002173	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
243230002174	Predicted membrane protein [Function unknown]; Region: COG4392
243230002175	6-phosphofructokinase; Provisional; Region: PRK03202
243230002176	active site
243230002177	ADP/pyrophosphate binding site [chemical binding]; other site
243230002178	dimerization interface [polypeptide binding]; other site
243230002179	allosteric effector site; other site
243230002180	fructose-1,6-bisphosphate binding site; other site
243230002181	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
243230002182	putative SAM binding site [chemical binding]; other site
243230002183	putative homodimer interface [polypeptide binding]; other site
243230002184	Cysteine-rich D. radiodurans N terminus; Region: CDRN; pfam05174
243230002185	S-adenosylmethionine synthetase; Validated; Region: PRK05250
243230002186	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
243230002187	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
243230002188	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
243230002189	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
243230002190	active site
243230002191	(T/H)XGH motif; other site
243230002192	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243230002193	S-adenosylmethionine binding site [chemical binding]; other site
243230002194	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
243230002195	GTP binding site; other site
243230002196	GTPase [General function prediction only]; Region: Era; COG1159
243230002197	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
243230002198	G1 box; other site
243230002199	GTP/Mg2+ binding site [chemical binding]; other site
243230002200	Switch I region; other site
243230002201	G2 box; other site
243230002202	Switch II region; other site
243230002203	G3 box; other site
243230002204	G4 box; other site
243230002205	G5 box; other site
243230002206	KH domain; Region: KH_2; pfam07650
243230002207	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
243230002208	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
243230002209	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243230002210	Walker A motif; other site
243230002211	ATP binding site [chemical binding]; other site
243230002212	Walker B motif; other site
243230002213	arginine finger; other site
243230002214	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
243230002215	Arginase family; Region: Arginase; cd09989
243230002216	active site
243230002217	Mn binding site [ion binding]; other site
243230002218	oligomer interface [polypeptide binding]; other site
243230002219	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
243230002220	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
243230002221	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
243230002222	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
243230002223	Putative lysophospholipase; Region: Hydrolase_4; cl19140
243230002224	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
243230002225	Predicted esterase [General function prediction only]; Region: COG0400
243230002226	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
243230002227	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
243230002228	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
243230002229	catalytic residues [active]
243230002230	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
243230002231	putative active site [active]
243230002232	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
243230002233	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
243230002234	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
243230002235	PLD-like domain; Region: PLDc_2; pfam13091
243230002236	putative active site [active]
243230002237	catalytic site [active]
243230002238	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
243230002239	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
243230002240	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
243230002241	Probable transposase; Region: OrfB_IS605; pfam01385
243230002242	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
243230002243	Transposase IS200 like; Region: Y1_Tnp; pfam01797
243230002244	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
243230002245	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
243230002246	ATP-grasp domain; Region: ATP-grasp_4; cl17255
243230002247	Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787
243230002248	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
243230002249	ATP-grasp domain; Region: ATP-grasp_4; cl17255
243230002250	Phosphotransferase enzyme family; Region: APH; pfam01636
243230002251	active site
243230002252	substrate binding site [chemical binding]; other site
243230002253	ATP binding site [chemical binding]; other site
243230002254	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
243230002255	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359
243230002256	putative dimer interface [polypeptide binding]; other site
243230002257	aminotransferase; Validated; Region: PRK07777
243230002258	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243230002259	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243230002260	homodimer interface [polypeptide binding]; other site
243230002261	catalytic residue [active]
243230002262	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
243230002263	ANP binding site [chemical binding]; other site
243230002264	Substrate Binding Site II [chemical binding]; other site
243230002265	Substrate Binding Site I [chemical binding]; other site
243230002266	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230002267	Coenzyme A binding pocket [chemical binding]; other site
243230002268	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
243230002269	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230002270	Coenzyme A binding pocket [chemical binding]; other site
243230002271	putative acetyltransferase; Provisional; Region: PRK03624
243230002272	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230002273	Coenzyme A binding pocket [chemical binding]; other site
243230002274	argininosuccinate lyase; Provisional; Region: PRK00855
243230002275	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
243230002276	active sites [active]
243230002277	tetramer interface [polypeptide binding]; other site
243230002278	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
243230002279	active site
243230002280	NTP binding site [chemical binding]; other site
243230002281	metal binding triad [ion binding]; metal-binding site
243230002282	antibiotic binding site [chemical binding]; other site
243230002283	Uncharacterized conserved protein [Function unknown]; Region: COG2361
243230002284	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230002285	Coenzyme A binding pocket [chemical binding]; other site
243230002286	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230002287	Coenzyme A binding pocket [chemical binding]; other site
243230002288	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
243230002289	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230002290	Coenzyme A binding pocket [chemical binding]; other site
243230002291	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
243230002292	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
243230002293	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
243230002294	catalytic site [active]
243230002295	subunit interface [polypeptide binding]; other site
243230002296	conserved repeat domain; Region: B_ant_repeat; TIGR01451
243230002297	Domain of unknown function DUF11; Region: DUF11; pfam01345
243230002298	Domain of unknown function DUF11; Region: DUF11; pfam01345
243230002299	Domain of unknown function DUF11; Region: DUF11; pfam01345
243230002300	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
243230002301	Domain of unknown function DUF11; Region: DUF11; pfam01345
243230002302	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
243230002303	Domain of unknown function DUF11; Region: DUF11; pfam01345
243230002304	Domain of unknown function DUF11; Region: DUF11; pfam01345
243230002305	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
243230002306	ligand binding site [chemical binding]; other site
243230002307	active site
243230002308	UGI interface [polypeptide binding]; other site
243230002309	catalytic site [active]
243230002310	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
243230002311	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659
243230002312	active site
243230002313	DNA binding site [nucleotide binding]
243230002314	Int/Topo IB signature motif; other site
243230002315	catalytic residues [active]
243230002316	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
243230002317	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
243230002318	Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811
243230002319	Archaeal/vacuolar-type H+-ATPase subunit I [Energy production and conversion]; Region: NtpI; COG1269
243230002320	Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390
243230002321	V-type ATP synthase subunit E; Provisional; Region: PRK01194
243230002322	F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192
243230002323	Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527
243230002324	ATP synthase (C/AC39) subunit; Region: vATP-synt_AC39; cl00660
243230002325	Archaeal/vacuolar-type H+-ATPase subunit F [Energy production and conversion]; Region: NtpG; COG1436
243230002326	V-type ATP synthase subunit A; Provisional; Region: PRK04192
243230002327	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
243230002328	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
243230002329	Walker A motif/ATP binding site; other site
243230002330	Walker B motif; other site
243230002331	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
243230002332	V-type ATP synthase subunit B; Provisional; Region: PRK04196
243230002333	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
243230002334	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
243230002335	Walker A motif homologous position; other site
243230002336	Walker B motif; other site
243230002337	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
243230002338	Archaeal/vacuolar-type H+-ATPase subunit D [Energy production and conversion]; Region: NtpD; COG1394
243230002339	Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297
243230002340	HD domain; Region: HD_3; pfam13023
243230002341	extracellular protein; Region: TIGR01370
243230002342	Uncharacterized conserved protein [Function unknown]; Region: COG3868
243230002343	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
243230002344	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243230002345	active site
243230002346	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
243230002347	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
243230002348	active site
243230002349	Substrate binding site; other site
243230002350	Mg++ binding site; other site
243230002351	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
243230002352	NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180
243230002353	NAD binding site [chemical binding]; other site
243230002354	substrate binding site [chemical binding]; other site
243230002355	active site
243230002356	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813
243230002357	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
243230002358	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
243230002359	active site
243230002360	SUMO-1 interface [polypeptide binding]; other site
243230002361	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
243230002362	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
243230002363	Moco binding site; other site
243230002364	metal coordination site [ion binding]; other site
243230002365	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
243230002366	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
243230002367	interface (dimer of trimers) [polypeptide binding]; other site
243230002368	Substrate-binding/catalytic site; other site
243230002369	Zn-binding sites [ion binding]; other site
243230002370	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
243230002371	tetramerization interface [polypeptide binding]; other site
243230002372	active site
243230002373	GAF domain; Region: GAF_3; pfam13492
243230002374	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
243230002375	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243230002376	Zn2+ binding site [ion binding]; other site
243230002377	Mg2+ binding site [ion binding]; other site
243230002378	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243230002379	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
243230002380	WHG domain; Region: WHG; pfam13305
243230002381	Uncharacterized conserved protein [Function unknown]; Region: COG4891
243230002382	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822
243230002383	putative hydrophobic ligand binding site [chemical binding]; other site
243230002384	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
243230002385	homodimer interface [polypeptide binding]; other site
243230002386	maltodextrin glucosidase; Provisional; Region: PRK10785
243230002387	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
243230002388	active site
243230002389	homodimer interface [polypeptide binding]; other site
243230002390	catalytic site [active]
243230002391	Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947
243230002392	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14965
243230002393	NADH-quinone oxidoreductase chain 15; Region: NADH_Oxid_Nqo15; pfam11497
243230002394	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
243230002395	putative substrate binding site [chemical binding]; other site
243230002396	putative ATP binding site [chemical binding]; other site
243230002397	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
243230002398	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
243230002399	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243230002400	motif II; other site
243230002401	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
243230002402	classical (c) SDRs; Region: SDR_c; cd05233
243230002403	NAD(P) binding site [chemical binding]; other site
243230002404	active site
243230002405	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243230002406	active site
243230002407	phosphorylation site [posttranslational modification]
243230002408	intermolecular recognition site; other site
243230002409	dimerization interface [polypeptide binding]; other site
243230002410	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
243230002411	substrate binding site [chemical binding]; other site
243230002412	glutamase interaction surface [polypeptide binding]; other site
243230002413	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
243230002414	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
243230002415	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
243230002416	metal binding site [ion binding]; metal-binding site
243230002417	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243230002418	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
243230002419	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
243230002420	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
243230002421	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
243230002422	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
243230002423	HlyD family secretion protein; Region: HlyD_3; pfam13437
243230002424	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
243230002425	MMPL family; Region: MMPL; cl14618
243230002426	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
243230002427	arginine repressor; Region: argR_whole; TIGR01529
243230002428	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
243230002429	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
243230002430	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243230002431	active site
243230002432	phosphorylation site [posttranslational modification]
243230002433	intermolecular recognition site; other site
243230002434	dimerization interface [polypeptide binding]; other site
243230002435	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
243230002436	DNA binding site [nucleotide binding]
243230002437	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243230002438	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243230002439	dimerization interface [polypeptide binding]; other site
243230002440	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243230002441	dimer interface [polypeptide binding]; other site
243230002442	phosphorylation site [posttranslational modification]
243230002443	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243230002444	ATP binding site [chemical binding]; other site
243230002445	Mg2+ binding site [ion binding]; other site
243230002446	G-X-G motif; other site
243230002447	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
243230002448	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
243230002449	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
243230002450	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
243230002451	active site
243230002452	catalytic residues [active]
243230002453	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
243230002454	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
243230002455	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
243230002456	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651
243230002457	PAS fold; Region: PAS_4; pfam08448
243230002458	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243230002459	putative active site [active]
243230002460	heme pocket [chemical binding]; other site
243230002461	PAS domain; Region: PAS_9; pfam13426
243230002462	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243230002463	metal binding site [ion binding]; metal-binding site
243230002464	active site
243230002465	I-site; other site
243230002466	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243230002467	cell division topological specificity factor MinE; Region: minE; TIGR01215
243230002468	septum site-determining protein MinD; Region: minD_bact; TIGR01968
243230002469	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
243230002470	P-loop; other site
243230002471	ADP binding residues [chemical binding]; other site
243230002472	Switch I; other site
243230002473	Switch II; other site
243230002474	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
243230002475	Thioredoxin; Region: Thioredoxin_4; pfam13462
243230002476	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
243230002477	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
243230002478	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
243230002479	Glycoprotease family; Region: Peptidase_M22; pfam00814
243230002480	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
243230002481	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118
243230002482	dimer interface [polypeptide binding]; other site
243230002483	active site
243230002484	coenzyme A binding site [chemical binding]; other site
243230002485	citrylCoA binding site [chemical binding]; other site
243230002486	oxalacetate/citrate binding site [chemical binding]; other site
243230002487	catalytic triad [active]
243230002488	Uncharacterized conserved protein [Function unknown]; Region: COG1801
243230002489	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243230002490	Walker A motif; other site
243230002491	ATP binding site [chemical binding]; other site
243230002492	Walker B motif; other site
243230002493	Beta-lactamase; Region: Beta-lactamase; pfam00144
243230002494	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
243230002495	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
243230002496	active site
243230002497	metal binding site [ion binding]; metal-binding site
243230002498	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
243230002499	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230002500	Coenzyme A binding pocket [chemical binding]; other site
243230002501	Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321
243230002502	lipoyl synthase; Provisional; Region: PRK05481
243230002503	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243230002504	FeS/SAM binding site; other site
243230002505	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
243230002506	PQQ-like domain; Region: PQQ_2; pfam13360
243230002507	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
243230002508	Trp docking motif [polypeptide binding]; other site
243230002509	active site
243230002510	short chain dehydrogenase; Provisional; Region: PRK08309
243230002511	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
243230002512	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
243230002513	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
243230002514	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
243230002515	type IV pilus assembly protein PilM; Region: pilM; TIGR01175
243230002516	Cell division protein FtsA; Region: FtsA; cl17206
243230002517	Cell division protein FtsA; Region: FtsA; pfam14450
243230002518	Fimbrial assembly protein (PilN); Region: PilN; cl19830
243230002519	Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741
243230002520	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
243230002521	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
243230002522	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
243230002523	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
243230002524	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
243230002525	Tetramer interface [polypeptide binding]; other site
243230002526	active site
243230002527	FMN-binding site [chemical binding]; other site
243230002528	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
243230002529	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
243230002530	ADP binding site [chemical binding]; other site
243230002531	magnesium binding site [ion binding]; other site
243230002532	putative shikimate binding site; other site
243230002533	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
243230002534	dimer interface [polypeptide binding]; other site
243230002535	active site
243230002536	metal binding site [ion binding]; metal-binding site
243230002537	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
243230002538	trimer interface [polypeptide binding]; other site
243230002539	active site
243230002540	dimer interface [polypeptide binding]; other site
243230002541	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
243230002542	Putative esterase; Region: Esterase; pfam00756
243230002543	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
243230002544	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243230002545	active site
243230002546	phosphorylation site [posttranslational modification]
243230002547	intermolecular recognition site; other site
243230002548	dimerization interface [polypeptide binding]; other site
243230002549	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
243230002550	DNA binding site [nucleotide binding]
243230002551	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
243230002552	putative active site pocket [active]
243230002553	cleavage site
243230002554	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
243230002555	nudix motif; other site
243230002556	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
243230002557	nudix motif; other site
243230002558	ORF080 virion core protein; Provisional; Region: PHA02682
243230002559	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
243230002560	active site
243230002561	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
243230002562	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
243230002563	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
243230002564	dimerization interface [polypeptide binding]; other site
243230002565	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
243230002566	ligand binding site [chemical binding]; other site
243230002567	cysteine synthase; Region: PLN02565
243230002568	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
243230002569	dimer interface [polypeptide binding]; other site
243230002570	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243230002571	catalytic residue [active]
243230002572	Predicted membrane protein [Function unknown]; Region: COG0344
243230002573	Predicted dehydrogenase [General function prediction only]; Region: COG5322
243230002574	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
243230002575	NAD(P) binding pocket [chemical binding]; other site
243230002576	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
243230002577	Putative lysophospholipase; Region: Hydrolase_4; cl19140
243230002578	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
243230002579	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
243230002580	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
243230002581	folate binding site [chemical binding]; other site
243230002582	NADP+ binding site [chemical binding]; other site
243230002583	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
243230002584	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
243230002585	inhibitor-cofactor binding pocket; inhibition site
243230002586	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243230002587	catalytic residue [active]
243230002588	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
243230002589	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
243230002590	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
243230002591	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230002592	Coenzyme A binding pocket [chemical binding]; other site
243230002593	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
243230002594	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
243230002595	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
243230002596	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
243230002597	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
243230002598	lycopene cyclase family protein; Region: carotene-cycl; TIGR01790
243230002599	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
243230002600	Anti-sigma-K factor rskA; Region: RskA; pfam10099
243230002601	putative anti-sigmaE protein; Provisional; Region: PRK13920
243230002602	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
243230002603	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
243230002604	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
243230002605	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
243230002606	Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682
243230002607	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14358
243230002608	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
243230002609	Substrate binding site; other site
243230002610	Mg++ binding site; other site
243230002611	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
243230002612	active site
243230002613	substrate binding site [chemical binding]; other site
243230002614	CoA binding site [chemical binding]; other site
243230002615	UbiA family of prenyltransferases (PTases), Unknown subgroup; Region: PT_UbiA_4; cd13966
243230002616	putative active site [active]
243230002617	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
243230002618	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
243230002619	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3169
243230002620	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
243230002621	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
243230002622	Subtilase family; Region: Peptidase_S8; pfam00082
243230002623	active site
243230002624	catalytic residues [active]
243230002625	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538
243230002626	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
243230002627	PA/protease or protease-like domain interface [polypeptide binding]; other site
243230002628	catalytic residues [active]
243230002629	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
243230002630	Glutamate binding site [chemical binding]; other site
243230002631	homodimer interface [polypeptide binding]; other site
243230002632	NAD binding site [chemical binding]; other site
243230002633	catalytic residues [active]
243230002634	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
243230002635	Proline dehydrogenase; Region: Pro_dh; pfam01619
243230002636	Transcriptional regulators [Transcription]; Region: FadR; COG2186
243230002637	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
243230002638	DNA-binding site [nucleotide binding]; DNA binding site
243230002639	FCD domain; Region: FCD; pfam07729
243230002640	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
243230002641	MgtC family; Region: MgtC; pfam02308
243230002642	Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381
243230002643	Recombination protein O N terminal; Region: RecO_N; pfam11967
243230002644	Recombination protein O C terminal; Region: RecO_C; pfam02565
243230002645	Cysteine-rich D. radiodurans N terminus; Region: CDRN; pfam05174
243230002646	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl19094
243230002647	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
243230002648	substrate binding pocket [chemical binding]; other site
243230002649	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
243230002650	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
243230002651	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
243230002652	putative NAD(P) binding site [chemical binding]; other site
243230002653	putative active site [active]
243230002654	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
243230002655	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
243230002656	nucleotide binding site [chemical binding]; other site
243230002657	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
243230002658	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
243230002659	active site
243230002660	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
243230002661	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
243230002662	DHH family; Region: DHH; pfam01368
243230002663	DHHA1 domain; Region: DHHA1; pfam02272
243230002664	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
243230002665	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243230002666	motif II; other site
243230002667	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
243230002668	tetramer interface [polypeptide binding]; other site
243230002669	active site
243230002670	Mg2+/Mn2+ binding site [ion binding]; other site
243230002671	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
243230002672	FOG: WD40 repeat [General function prediction only]; Region: COG2319
243230002673	structural tetrad; other site
243230002674	Ion transport protein; Region: Ion_trans; pfam00520
243230002675	Ion channel; Region: Ion_trans_2; pfam07885
243230002676	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
243230002677	Double zinc ribbon; Region: DZR; pfam12773
243230002678	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
243230002679	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
243230002680	putative NAD(P) binding site [chemical binding]; other site
243230002681	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
243230002682	putative active site [active]
243230002683	Zn binding site [ion binding]; other site
243230002684	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
243230002685	CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918
243230002686	ligand binding site [chemical binding]; other site
243230002687	flexible hinge region; other site
243230002688	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
243230002689	putative switch regulator; other site
243230002690	non-specific DNA interactions [nucleotide binding]; other site
243230002691	DNA binding site [nucleotide binding]
243230002692	sequence specific DNA binding site [nucleotide binding]; other site
243230002693	putative cAMP binding site [chemical binding]; other site
243230002694	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2380
243230002695	HerA helicase [Replication, recombination, and repair]; Region: COG0433
243230002696	Domain of unknown function DUF87; Region: DUF87; cl19135
243230002697	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
243230002698	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
243230002699	DNA-binding site [nucleotide binding]; DNA binding site
243230002700	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243230002701	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243230002702	homodimer interface [polypeptide binding]; other site
243230002703	catalytic residue [active]
243230002704	metal-dependent hydrolase; Provisional; Region: PRK13291
243230002705	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
243230002706	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
243230002707	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
243230002708	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
243230002709	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
243230002710	catalytic residues [active]
243230002711	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; cl19840
243230002712	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
243230002713	tetramer (dimer of dimers) interface [polypeptide binding]; other site
243230002714	active site
243230002715	dimer interface [polypeptide binding]; other site
243230002716	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
243230002717	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
243230002718	catalytic triad [active]
243230002719	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
243230002720	CoenzymeA binding site [chemical binding]; other site
243230002721	subunit interaction site [polypeptide binding]; other site
243230002722	PHB binding site; other site
243230002723	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
243230002724	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
243230002725	Peptidase family M23; Region: Peptidase_M23; pfam01551
243230002726	4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959
243230002727	putative active site [active]
243230002728	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
243230002729	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
243230002730	G1 box; other site
243230002731	GTP/Mg2+ binding site [chemical binding]; other site
243230002732	G2 box; other site
243230002733	Switch I region; other site
243230002734	G3 box; other site
243230002735	Switch II region; other site
243230002736	G4 box; other site
243230002737	G5 box; other site
243230002738	Roadblock/LC7 domain; Region: Robl_LC7; pfam03259
243230002739	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
243230002740	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
243230002741	active site
243230002742	catalytic site [active]
243230002743	substrate binding site [chemical binding]; other site
243230002744	CAAX protease self-immunity; Region: Abi; pfam02517
243230002745	RraA famliy; Region: NOT-MenG; TIGR01935
243230002746	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243230002747	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
243230002748	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243230002749	dimer interface [polypeptide binding]; other site
243230002750	phosphorylation site [posttranslational modification]
243230002751	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243230002752	ATP binding site [chemical binding]; other site
243230002753	Mg2+ binding site [ion binding]; other site
243230002754	G-X-G motif; other site
243230002755	phytoene desaturase; Region: crtI_fam; TIGR02734
243230002756	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
243230002757	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
243230002758	active site lid residues [active]
243230002759	substrate binding pocket [chemical binding]; other site
243230002760	catalytic residues [active]
243230002761	substrate-Mg2+ binding site; other site
243230002762	aspartate-rich region 1; other site
243230002763	aspartate-rich region 2; other site
243230002764	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
243230002765	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
243230002766	metal binding site 2 [ion binding]; metal-binding site
243230002767	putative DNA binding helix; other site
243230002768	metal binding site 1 [ion binding]; metal-binding site
243230002769	dimer interface [polypeptide binding]; other site
243230002770	structural Zn2+ binding site [ion binding]; other site
243230002771	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
243230002772	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
243230002773	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
243230002774	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
243230002775	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
243230002776	homodimer interface [polypeptide binding]; other site
243230002777	NADP binding site [chemical binding]; other site
243230002778	substrate binding site [chemical binding]; other site
243230002779	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
243230002780	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
243230002781	purine monophosphate binding site [chemical binding]; other site
243230002782	dimer interface [polypeptide binding]; other site
243230002783	putative catalytic residues [active]
243230002784	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
243230002785	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
243230002786	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
243230002787	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
243230002788	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
243230002789	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
243230002790	homodimer interface [polypeptide binding]; other site
243230002791	substrate-cofactor binding pocket; other site
243230002792	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243230002793	catalytic residue [active]
243230002794	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
243230002795	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
243230002796	Zn binding site [ion binding]; other site
243230002797	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
243230002798	nudix motif; other site
243230002799	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
243230002800	active site
243230002801	monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645
243230002802	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
243230002803	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
243230002804	monovalent cation:proton antiporter; Region: 2a6301s02; TIGR00943
243230002805	Multicomponent Na+:H+ antiporter, MnhC subunit; Region: 2a6301s03; TIGR00941
243230002806	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
243230002807	Multisubunit Na+/H+ antiporter, MnhE subunit [Inorganic ion transport and metabolism]; Region: MnhE; COG1863
243230002808	Multisubunit Na+/H+ antiporter, MnhF subunit [Inorganic ion transport and metabolism]; Region: MnhF; COG2212
243230002809	monovalent cation/proton antiporter, MnhG/PhaG subunit; Region: CPA3_mnhG_phaG; TIGR01300
243230002810	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
243230002811	bacterial OsmY and nodulation domain; Region: BON; smart00749
243230002812	bacterial OsmY and nodulation domain; Region: BON; smart00749
243230002813	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
243230002814	Domain of unknown function (DUF1844); Region: DUF1844; pfam08899
243230002815	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
243230002816	putative active site [active]
243230002817	dimerization interface [polypeptide binding]; other site
243230002818	putative tRNAtyr binding site [nucleotide binding]; other site
243230002819	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
243230002820	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243230002821	active site
243230002822	phosphorylation site [posttranslational modification]
243230002823	intermolecular recognition site; other site
243230002824	dimerization interface [polypeptide binding]; other site
243230002825	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
243230002826	DNA binding residues [nucleotide binding]
243230002827	dimerization interface [polypeptide binding]; other site
243230002828	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243230002829	HAMP domain; Region: HAMP; pfam00672
243230002830	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243230002831	dimer interface [polypeptide binding]; other site
243230002832	phosphorylation site [posttranslational modification]
243230002833	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243230002834	ATP binding site [chemical binding]; other site
243230002835	Mg2+ binding site [ion binding]; other site
243230002836	G-X-G motif; other site
243230002837	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
243230002838	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
243230002839	PRC-barrel domain; Region: PRC; pfam05239
243230002840	PRC-barrel domain; Region: PRC; pfam05239
243230002841	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
243230002842	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
243230002843	RNA binding surface [nucleotide binding]; other site
243230002844	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
243230002845	active site
243230002846	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
243230002847	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
243230002848	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
243230002849	RNA/DNA hybrid binding site [nucleotide binding]; other site
243230002850	active site
243230002851	Protein of unknown function (DUF3197); Region: DUF3197; pfam11432
243230002852	Ribosome-binding factor A [Translation, ribosomal structure and biogenesis]; Region: RbfA; COG0858
243230002853	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
243230002854	active site
243230002855	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
243230002856	metal ion-dependent adhesion site (MIDAS); other site
243230002857	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
243230002858	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243230002859	ATP binding site [chemical binding]; other site
243230002860	Mg2+ binding site [ion binding]; other site
243230002861	G-X-G motif; other site
243230002862	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
243230002863	anchoring element; other site
243230002864	dimer interface [polypeptide binding]; other site
243230002865	ATP binding site [chemical binding]; other site
243230002866	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
243230002867	active site
243230002868	putative metal-binding site [ion binding]; other site
243230002869	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
243230002870	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
243230002871	DNA-binding site [nucleotide binding]; DNA binding site
243230002872	RNA-binding motif; other site
243230002873	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
243230002874	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
243230002875	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
243230002876	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
243230002877	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
243230002878	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
243230002879	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
243230002880	Largest subunit of RNA polymerase (RNAP), N-terminal domain; Region: RNAP_largest_subunit_N; cl19114
243230002881	Zn-binding [ion binding]; other site
243230002882	Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609
243230002883	beta and beta' interface [polypeptide binding]; other site
243230002884	beta' and sigma factor interface [polypeptide binding]; other site
243230002885	active site region [active]
243230002886	catalytic site [active]
243230002887	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
243230002888	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
243230002889	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
243230002890	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
243230002891	G-loop; other site
243230002892	DNA binding site [nucleotide binding]
243230002893	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
243230002894	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
243230002895	RPB12 interaction site [polypeptide binding]; other site
243230002896	RPB1 interaction site [polypeptide binding]; other site
243230002897	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
243230002898	RPB10 interaction site [polypeptide binding]; other site
243230002899	RPB11 interaction site [polypeptide binding]; other site
243230002900	RPB3 interaction site [polypeptide binding]; other site
243230002901	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
243230002902	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243230002903	S-adenosylmethionine binding site [chemical binding]; other site
243230002904	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
243230002905	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
243230002906	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
243230002907	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
243230002908	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
243230002909	DNA binding residues [nucleotide binding]
243230002910	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
243230002911	MoxR-like ATPases [General function prediction only]; Region: COG0714
243230002912	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243230002913	Walker A motif; other site
243230002914	ATP binding site [chemical binding]; other site
243230002915	Walker B motif; other site
243230002916	arginine finger; other site
243230002917	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
243230002918	Protein of unknown function DUF58; Region: DUF58; pfam01882
243230002919	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
243230002920	homodimer interface [polypeptide binding]; other site
243230002921	substrate-cofactor binding pocket; other site
243230002922	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243230002923	catalytic residue [active]
243230002924	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
243230002925	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
243230002926	active site
243230002927	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
243230002928	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
243230002929	TIGR00153 family protein; Region: TIGR00153
243230002930	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
243230002931	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
243230002932	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
243230002933	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
243230002934	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243230002935	Walker A/P-loop; other site
243230002936	ATP binding site [chemical binding]; other site
243230002937	Q-loop/lid; other site
243230002938	ABC transporter signature motif; other site
243230002939	Walker B; other site
243230002940	D-loop; other site
243230002941	H-loop/switch region; other site
243230002942	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
243230002943	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
243230002944	minor groove reading motif; other site
243230002945	helix-hairpin-helix signature motif; other site
243230002946	substrate binding pocket [chemical binding]; other site
243230002947	active site
243230002948	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
243230002949	acylphosphatase; Provisional; Region: PRK14433
243230002950	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
243230002951	active site
243230002952	substrate binding pocket [chemical binding]; other site
243230002953	homodimer interaction site [polypeptide binding]; other site
243230002954	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
243230002955	substrate binding pocket [chemical binding]; other site
243230002956	chain length determination region; other site
243230002957	substrate-Mg2+ binding site; other site
243230002958	catalytic residues [active]
243230002959	aspartate-rich region 1; other site
243230002960	active site lid residues [active]
243230002961	aspartate-rich region 2; other site
243230002962	Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324
243230002963	trehalose synthase; Region: treS_nterm; TIGR02456
243230002964	active site
243230002965	catalytic site [active]
243230002966	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
243230002967	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
243230002968	DNA binding residues [nucleotide binding]
243230002969	putative dimer interface [polypeptide binding]; other site
243230002970	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
243230002971	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
243230002972	DNA binding residues [nucleotide binding]
243230002973	putative dimer interface [polypeptide binding]; other site
243230002974	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
243230002975	active site
243230002976	metal binding site [ion binding]; metal-binding site
243230002977	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
243230002978	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243230002979	FeS/SAM binding site; other site
243230002980	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
243230002981	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243230002982	TPR motif; other site
243230002983	binding surface
243230002984	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
243230002985	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243230002986	TPR motif; other site
243230002987	binding surface
243230002988	Sporulation related domain; Region: SPOR; pfam05036
243230002989	Sporulation related domain; Region: SPOR; pfam05036
243230002990	AT-rich DNA-binding protein [General function prediction only]; Region: COG2344
243230002991	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
243230002992	CoA binding domain; Region: CoA_binding; pfam02629
243230002993	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
243230002994	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243230002995	catalytic residue [active]
243230002996	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
243230002997	substrate binding site [chemical binding]; other site
243230002998	active site
243230002999	catalytic residues [active]
243230003000	heterodimer interface [polypeptide binding]; other site
243230003001	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547
243230003002	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
243230003003	catalytic residues [active]
243230003004	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
243230003005	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
243230003006	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
243230003007	metal binding site [ion binding]; metal-binding site
243230003008	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
243230003009	conserved cis-peptide bond; other site
243230003010	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
243230003011	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
243230003012	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
243230003013	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
243230003014	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
243230003015	catalytic loop [active]
243230003016	iron binding site [ion binding]; other site
243230003017	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
243230003018	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
243230003019	L-aspartate oxidase; Provisional; Region: PRK06175
243230003020	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
243230003021	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500
243230003022	putative Iron-sulfur protein interface [polypeptide binding]; other site
243230003023	putative proximal heme binding site [chemical binding]; other site
243230003024	putative SdhC-like subunit interface [polypeptide binding]; other site
243230003025	putative distal heme binding site [chemical binding]; other site
243230003026	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501
243230003027	putative Iron-sulfur protein interface [polypeptide binding]; other site
243230003028	putative proximal heme binding site [chemical binding]; other site
243230003029	putative SdhD-like interface [polypeptide binding]; other site
243230003030	putative distal heme binding site [chemical binding]; other site
243230003031	PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393
243230003032	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
243230003033	active site
243230003034	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
243230003035	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
243230003036	Walker A/P-loop; other site
243230003037	ATP binding site [chemical binding]; other site
243230003038	Q-loop/lid; other site
243230003039	ABC transporter signature motif; other site
243230003040	Walker B; other site
243230003041	D-loop; other site
243230003042	H-loop/switch region; other site
243230003043	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
243230003044	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
243230003045	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243230003046	dimer interface [polypeptide binding]; other site
243230003047	conserved gate region; other site
243230003048	putative PBP binding loops; other site
243230003049	ABC-ATPase subunit interface; other site
243230003050	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
243230003051	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243230003052	dimer interface [polypeptide binding]; other site
243230003053	conserved gate region; other site
243230003054	putative PBP binding loops; other site
243230003055	ABC-ATPase subunit interface; other site
243230003056	FOG: WD40 repeat [General function prediction only]; Region: COG2319
243230003057	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
243230003058	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
243230003059	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
243230003060	active site
243230003061	Predicted flavoprotein [General function prediction only]; Region: COG0431
243230003062	N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850
243230003063	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
243230003064	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935
243230003065	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
243230003066	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
243230003067	choline dehydrogenase; Validated; Region: PRK02106
243230003068	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
243230003069	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
243230003070	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
243230003071	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
243230003072	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
243230003073	substrate binding pocket [chemical binding]; other site
243230003074	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
243230003075	B12 binding site [chemical binding]; other site
243230003076	cobalt ligand [ion binding]; other site
243230003077	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
243230003078	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
243230003079	5,10-methylenetetrahydrofolate reductase [Amino acid transport and metabolism]; Region: MetF; COG0685
243230003080	FAD binding site [chemical binding]; other site
243230003081	Uncharacterized conserved protein [Function unknown]; Region: COG5316
243230003082	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
243230003083	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
243230003084	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
243230003085	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
243230003086	Ligand binding site [chemical binding]; other site
243230003087	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
243230003088	hypothetical protein; Validated; Region: PRK06217
243230003089	Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563
243230003090	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
243230003091	nudix motif; other site
243230003092	peptide chain release factor 1; Validated; Region: prfA; PRK00591
243230003093	PCRF domain; Region: PCRF; pfam03462
243230003094	RF-1 domain; Region: RF-1; pfam00472
243230003095	phosphoenolpyruvate carboxykinase; Provisional; Region: PRK09344
243230003096	active site
243230003097	metal-binding site [ion binding]
243230003098	nucleotide-binding site [chemical binding]; other site
243230003099	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
243230003100	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
243230003101	Probable transposase; Region: OrfB_IS605; pfam01385
243230003102	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
243230003103	Transposase IS200 like; Region: Y1_Tnp; pfam01797
243230003104	Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812
243230003105	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208
243230003106	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
243230003107	NAD(P) binding site [chemical binding]; other site
243230003108	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243230003109	metal binding site [ion binding]; metal-binding site
243230003110	active site
243230003111	I-site; other site
243230003112	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
243230003113	Peptidase family M50; Region: Peptidase_M50; pfam02163
243230003114	active site
243230003115	putative substrate binding region [chemical binding]; other site
243230003116	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
243230003117	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
243230003118	active site
243230003119	NTP binding site [chemical binding]; other site
243230003120	metal binding triad [ion binding]; metal-binding site
243230003121	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
243230003122	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
243230003123	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
243230003124	dimerization interface [polypeptide binding]; other site
243230003125	domain crossover interface; other site
243230003126	redox-dependent activation switch; other site
243230003127	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
243230003128	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
243230003129	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
243230003130	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243230003131	active site
243230003132	phosphorylation site [posttranslational modification]
243230003133	intermolecular recognition site; other site
243230003134	dimerization interface [polypeptide binding]; other site
243230003135	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
243230003136	DNA binding residues [nucleotide binding]
243230003137	dimerization interface [polypeptide binding]; other site
243230003138	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825
243230003139	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825
243230003140	FOG: CBS domain [General function prediction only]; Region: COG0517
243230003141	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
243230003142	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
243230003143	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
243230003144	homodimer interface [polypeptide binding]; other site
243230003145	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243230003146	catalytic residue [active]
243230003147	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
243230003148	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
243230003149	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
243230003150	Roadblock/LC7 domain; Region: Robl_LC7; pfam03259
243230003151	Roadblock/LC7 domain; Region: Robl_LC7; smart00960
243230003152	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
243230003153	Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018
243230003154	CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918
243230003155	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
243230003156	ligand binding site [chemical binding]; other site
243230003157	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
243230003158	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
243230003159	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
243230003160	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
243230003161	Predicted transcriptional regulator [Transcription]; Region: COG2345
243230003162	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
243230003163	putative DNA binding site [nucleotide binding]; other site
243230003164	putative Zn2+ binding site [ion binding]; other site
243230003165	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
243230003166	chorismate mutase domain of gram positive AroA protein; Region: CM_A; TIGR01801
243230003167	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
243230003168	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
243230003169	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
243230003170	apolar tunnel; other site
243230003171	heme binding site [chemical binding]; other site
243230003172	dimerization interface [polypeptide binding]; other site
243230003173	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243230003174	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
243230003175	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
243230003176	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
243230003177	deoxyguanosinetriphosphate triphosphohydrolase, putative; Region: dGTP_triPase; TIGR01353
243230003178	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243230003179	Zn2+ binding site [ion binding]; other site
243230003180	Mg2+ binding site [ion binding]; other site
243230003181	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
243230003182	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
243230003183	dimer interface [polypeptide binding]; other site
243230003184	ADP-ribose binding site [chemical binding]; other site
243230003185	active site
243230003186	nudix motif; other site
243230003187	metal binding site [ion binding]; metal-binding site
243230003188	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
243230003189	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
243230003190	active site
243230003191	Riboflavin kinase; Region: Flavokinase; smart00904
243230003192	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
243230003193	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
243230003194	Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107
243230003195	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
243230003196	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243230003197	Walker A/P-loop; other site
243230003198	ATP binding site [chemical binding]; other site
243230003199	Q-loop/lid; other site
243230003200	ABC transporter signature motif; other site
243230003201	Walker B; other site
243230003202	D-loop; other site
243230003203	H-loop/switch region; other site
243230003204	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
243230003205	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
243230003206	active site
243230003207	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
243230003208	Predicted GTPase [General function prediction only]; Region: ThdF; COG0486
243230003209	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
243230003210	trmE is a tRNA modification GTPase; Region: trmE; cd04164
243230003211	G1 box; other site
243230003212	GTP/Mg2+ binding site [chemical binding]; other site
243230003213	Switch I region; other site
243230003214	G2 box; other site
243230003215	Switch II region; other site
243230003216	G3 box; other site
243230003217	G4 box; other site
243230003218	G5 box; other site
243230003219	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
243230003220	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
243230003221	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
243230003222	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
243230003223	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
243230003224	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
243230003225	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
243230003226	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243230003227	Walker A motif; other site
243230003228	ATP binding site [chemical binding]; other site
243230003229	Walker B motif; other site
243230003230	arginine finger; other site
243230003231	Peptidase family M41; Region: Peptidase_M41; pfam01434
243230003232	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
243230003233	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
243230003234	homodimer interface [polypeptide binding]; other site
243230003235	metal binding site [ion binding]; metal-binding site
243230003236	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108
243230003237	metal-dependent hydrolase; Provisional; Region: PRK13291
243230003238	DR1025 from Deinococcus radiodurans, a member of the Nudix hydrolase superfamily, show nucleoside triphosphatase and dinucleoside polyphosphate pyrophosphatase activities. Like other enzymes belonging to this superfamily, it requires a divalent cation; Region: DR1025_like; cd04700
243230003239	dimer interface [polypeptide binding]; other site
243230003240	active site
243230003241	ATP binding site [chemical binding]; other site
243230003242	Mg2+ binding site [ion binding]; other site
243230003243	nudix motif; other site
243230003244	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
243230003245	FAD binding domain; Region: FAD_binding_4; pfam01565
243230003246	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
243230003247	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243230003248	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243230003249	substrate binding pocket [chemical binding]; other site
243230003250	membrane-bound complex binding site; other site
243230003251	hinge residues; other site
243230003252	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
243230003253	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243230003254	dimer interface [polypeptide binding]; other site
243230003255	conserved gate region; other site
243230003256	putative PBP binding loops; other site
243230003257	ABC-ATPase subunit interface; other site
243230003258	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
243230003259	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
243230003260	non-specific DNA binding site [nucleotide binding]; other site
243230003261	salt bridge; other site
243230003262	sequence-specific DNA binding site [nucleotide binding]; other site
243230003263	Cupin domain; Region: Cupin_2; pfam07883
243230003264	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
243230003265	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243230003266	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243230003267	homodimer interface [polypeptide binding]; other site
243230003268	catalytic residue [active]
243230003269	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
243230003270	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
243230003271	active site
243230003272	substrate binding site [chemical binding]; other site
243230003273	FMN binding site [chemical binding]; other site
243230003274	putative catalytic residues [active]
243230003275	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
243230003276	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
243230003277	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
243230003278	Walker A/P-loop; other site
243230003279	ATP binding site [chemical binding]; other site
243230003280	Q-loop/lid; other site
243230003281	ABC transporter signature motif; other site
243230003282	Walker B; other site
243230003283	D-loop; other site
243230003284	H-loop/switch region; other site
243230003285	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
243230003286	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
243230003287	Walker A/P-loop; other site
243230003288	ATP binding site [chemical binding]; other site
243230003289	Q-loop/lid; other site
243230003290	ABC transporter signature motif; other site
243230003291	Walker B; other site
243230003292	D-loop; other site
243230003293	H-loop/switch region; other site
243230003294	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
243230003295	TM-ABC transporter signature motif; other site
243230003296	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
243230003297	TM-ABC transporter signature motif; other site
243230003298	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
243230003299	dimerization interface [polypeptide binding]; other site
243230003300	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
243230003301	ligand binding site [chemical binding]; other site
243230003302	MutS domain I; Region: MutS_I; pfam01624
243230003303	MutS domain II; Region: MutS_II; pfam05188
243230003304	Predicted secreted hydrolase [General function prediction only]; Region: COG5621
243230003305	Predicted transcriptional regulators [Transcription]; Region: COG1695
243230003306	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
243230003307	Clp amino terminal domain; Region: Clp_N; pfam02861
243230003308	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243230003309	Walker A motif; other site
243230003310	ATP binding site [chemical binding]; other site
243230003311	Walker B motif; other site
243230003312	arginine finger; other site
243230003313	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243230003314	Walker A motif; other site
243230003315	ATP binding site [chemical binding]; other site
243230003316	Walker B motif; other site
243230003317	arginine finger; other site
243230003318	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
243230003319	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
243230003320	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
243230003321	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4367
243230003322	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
243230003323	MOSC domain; Region: MOSC; pfam03473
243230003324	Spermidine synthase [Amino acid transport and metabolism]; Region: SpeE; COG0421
243230003325	Putative lysophospholipase; Region: Hydrolase_4; cl19140
243230003326	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
243230003327	aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159
243230003328	Asp_Lys_Asn_RS_N: N-terminal, anticodon recognition domain of class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop.  Class 2b aaRSs include the homodimeric aspartyl-; Region: Asp_Lys_Asn_RS_N; cd04100
243230003329	Dimer interface [polypeptide binding]; other site
243230003330	anticodon binding site; other site
243230003331	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
243230003332	homodimer interface [polypeptide binding]; other site
243230003333	motif 1; other site
243230003334	motif 2; other site
243230003335	active site
243230003336	motif 3; other site
243230003337	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243230003338	putative substrate translocation pore; other site
243230003339	PUCC protein; Region: PUCC; pfam03209
243230003340	putative acetyltransferase; Provisional; Region: PRK03624
243230003341	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230003342	Coenzyme A binding pocket [chemical binding]; other site
243230003343	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
243230003344	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230003345	Coenzyme A binding pocket [chemical binding]; other site
243230003346	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
243230003347	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230003348	Coenzyme A binding pocket [chemical binding]; other site
243230003349	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230003350	Coenzyme A binding pocket [chemical binding]; other site
243230003351	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243230003352	Zn2+ binding site [ion binding]; other site
243230003353	Mg2+ binding site [ion binding]; other site
243230003354	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
243230003355	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
243230003356	Walker A; other site
243230003357	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
243230003358	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
243230003359	NAD(P) binding site [chemical binding]; other site
243230003360	Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348
243230003361	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
243230003362	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
243230003363	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
243230003364	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
243230003365	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
243230003366	Protein of unknown function (DUF664); Region: DUF664; pfam04978
243230003367	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
243230003368	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
243230003369	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
243230003370	Peptidase E [Amino acid transport and metabolism]; Region: PepE; COG3340
243230003371	conserved cys residue [active]
243230003372	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350
243230003373	putative acyltransferase; Provisional; Region: PRK05790
243230003374	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
243230003375	dimer interface [polypeptide binding]; other site
243230003376	active site
243230003377	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
243230003378	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
243230003379	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707
243230003380	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
243230003381	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
243230003382	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
243230003383	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959
243230003384	NodB motif; other site
243230003385	putative active site [active]
243230003386	putative catalytic site [active]
243230003387	putative Zn binding site [ion binding]; other site
243230003388	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243230003389	S-adenosylmethionine binding site [chemical binding]; other site
243230003390	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
243230003391	Ligand binding site; other site
243230003392	Putative Catalytic site; other site
243230003393	DXD motif; other site
243230003394	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
243230003395	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243230003396	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
243230003397	30S subunit binding site; other site
243230003398	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
243230003399	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
243230003400	active site
243230003401	substrate binding site [chemical binding]; other site
243230003402	coenzyme B12 binding site [chemical binding]; other site
243230003403	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
243230003404	B12 binding site [chemical binding]; other site
243230003405	cobalt ligand [ion binding]; other site
243230003406	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
243230003407	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243230003408	S-adenosylmethionine binding site [chemical binding]; other site
243230003409	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
243230003410	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
243230003411	active site
243230003412	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
243230003413	dimer interface [polypeptide binding]; other site
243230003414	substrate binding site [chemical binding]; other site
243230003415	catalytic residues [active]
243230003416	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
243230003417	FMN binding site [chemical binding]; other site
243230003418	homodimer contacts [polypeptide binding]; other site
243230003419	putative active site [active]
243230003420	putative substrate binding site [chemical binding]; other site
243230003421	homotetramer interface [polypeptide binding]; other site
243230003422	Zn-ribbon-containing, possibly RNA-binding protein and truncated derivatives [General function prediction only]; Region: COG5512
243230003423	recombination protein F; Provisional; Region: recF; PRK14079
243230003424	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
243230003425	Walker A/P-loop; other site
243230003426	ATP binding site [chemical binding]; other site
243230003427	Q-loop/lid; other site
243230003428	ABC transporter signature motif; other site
243230003429	Walker B; other site
243230003430	D-loop; other site
243230003431	H-loop/switch region; other site
243230003432	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
243230003433	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243230003434	metal binding site [ion binding]; metal-binding site
243230003435	active site
243230003436	I-site; other site
243230003437	YcaO domain protein; Region: TIGR03549
243230003438	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
243230003439	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
243230003440	active site
243230003441	HIGH motif; other site
243230003442	dimer interface [polypeptide binding]; other site
243230003443	KMSKS motif; other site
243230003444	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4298
243230003445	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
243230003446	3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356
243230003447	hinge; other site
243230003448	active site
243230003449	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
243230003450	catalytic core [active]
243230003451	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544
243230003452	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
243230003453	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
243230003454	active site residue [active]
243230003455	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243230003456	S-adenosylmethionine binding site [chemical binding]; other site
243230003457	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
243230003458	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
243230003459	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
243230003460	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
243230003461	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
243230003462	DNA repair protein RadA; Provisional; Region: PRK11823
243230003463	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
243230003464	Walker A motif/ATP binding site; other site
243230003465	ATP binding site [chemical binding]; other site
243230003466	Walker B motif; other site
243230003467	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
243230003468	dihydroorotase; Validated; Region: pyrC; PRK09357
243230003469	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
243230003470	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
243230003471	active site
243230003472	Protein of unknown function (DUF3995); Region: DUF3995; pfam13160
243230003473	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
243230003474	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
243230003475	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
243230003476	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
243230003477	active site
243230003478	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
243230003479	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282
243230003480	DNA binding residues [nucleotide binding]
243230003481	putative dimer interface [polypeptide binding]; other site
243230003482	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
243230003483	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
243230003484	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
243230003485	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
243230003486	putative dimer interface [polypeptide binding]; other site
243230003487	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
243230003488	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
243230003489	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
243230003490	Clp amino terminal domain; Region: Clp_N; pfam02861
243230003491	Clp amino terminal domain; Region: Clp_N; pfam02861
243230003492	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243230003493	Walker A motif; other site
243230003494	ATP binding site [chemical binding]; other site
243230003495	Walker B motif; other site
243230003496	arginine finger; other site
243230003497	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243230003498	Walker A motif; other site
243230003499	ATP binding site [chemical binding]; other site
243230003500	Walker B motif; other site
243230003501	arginine finger; other site
243230003502	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
243230003503	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
243230003504	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
243230003505	putative active site [active]
243230003506	Deinococcus radiodurans DR1119 and related proteins, metallophosphatase domain; Region: MPP_DR1119; cd07393
243230003507	putative active site [active]
243230003508	putative metal binding site [ion binding]; other site
243230003509	Butyrate kinase [Energy production and conversion]; Region: COG3426
243230003510	prephenate dehydrogenase; Validated; Region: PRK06545
243230003511	prephenate dehydrogenase; Validated; Region: PRK08507
243230003512	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
243230003513	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275
243230003514	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
243230003515	hinge; other site
243230003516	active site
243230003517	S-layer homology domain; Region: SLH; pfam00395
243230003518	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
243230003519	Single-stranded DNA-specific exonuclease [DNA replication, recombination, and repair]; Region: RecJ; COG0608
243230003520	DHH family; Region: DHH; pfam01368
243230003521	DHHA1 domain; Region: DHHA1; pfam02272
243230003522	Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853
243230003523	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
243230003524	Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232
243230003525	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
243230003526	Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276
243230003527	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
243230003528	C-terminal domain interface [polypeptide binding]; other site
243230003529	active site
243230003530	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
243230003531	active site
243230003532	N-terminal domain interface [polypeptide binding]; other site
243230003533	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
243230003534	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
243230003535	substrate binding site [chemical binding]; other site
243230003536	active site
243230003537	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
243230003538	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230003539	Coenzyme A binding pocket [chemical binding]; other site
243230003540	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
243230003541	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
243230003542	Inorganic pyrophosphatase [Energy production and conversion]; Region: Ppa; COG0221
243230003543	metal binding sites [ion binding]; metal-binding site
243230003544	dimer interface [polypeptide binding]; other site
243230003545	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
243230003546	Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128
243230003547	active site
243230003548	homodimer interface [polypeptide binding]; other site
243230003549	catalytic site [active]
243230003550	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
243230003551	MAEBL; Provisional; Region: PTZ00121
243230003552	GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440
243230003553	GIY-YIG motif/motif A; other site
243230003554	putative active site [active]
243230003555	putative metal binding site [ion binding]; other site
243230003556	GTP-binding protein LepA; Provisional; Region: PRK05433
243230003557	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
243230003558	G1 box; other site
243230003559	putative GEF interaction site [polypeptide binding]; other site
243230003560	GTP/Mg2+ binding site [chemical binding]; other site
243230003561	Switch I region; other site
243230003562	G2 box; other site
243230003563	G3 box; other site
243230003564	Switch II region; other site
243230003565	G4 box; other site
243230003566	G5 box; other site
243230003567	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
243230003568	Elongation Factor G, domain II; Region: EFG_II; pfam14492
243230003569	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
243230003570	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
243230003571	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
243230003572	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
243230003573	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
243230003574	Prephenate dehydratase; Region: PDT; pfam00800
243230003575	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
243230003576	putative L-Phe binding site [chemical binding]; other site
243230003577	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
243230003578	TrkA-C domain; Region: TrkA_C; pfam02080
243230003579	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
243230003580	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14334
243230003581	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
243230003582	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243230003583	FeS/SAM binding site; other site
243230003584	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
243230003585	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
243230003586	substrate binding site [chemical binding]; other site
243230003587	oxyanion hole (OAH) forming residues; other site
243230003588	trimer interface [polypeptide binding]; other site
243230003589	putative allantoin catabolism protein; Region: ura-cupin; TIGR03214
243230003590	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
243230003591	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
243230003592	allantoinase; Provisional; Region: PRK06189
243230003593	L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315
243230003594	active site
243230003595	allantoate amidohydrolase; Reviewed; Region: PRK09290
243230003596	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
243230003597	active site
243230003598	metal binding site [ion binding]; metal-binding site
243230003599	dimer interface [polypeptide binding]; other site
243230003600	malate synthase; Validated; Region: PRK09255
243230003601	active site
243230003602	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
243230003603	Transcriptional regulator [Transcription]; Region: IclR; COG1414
243230003604	Bacterial transcriptional regulator; Region: IclR; pfam01614
243230003605	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
243230003606	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
243230003607	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195
243230003608	Transcriptional regulators [Transcription]; Region: MarR; COG1846
243230003609	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
243230003610	Uricase (urate oxidase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3648
243230003611	Urate oxidase (UO, uricase) is a peroxisomal enzyme that catalyzes the oxidation of uric acid to allantoin in most fish, amphibian, and mammalian species. The enzymatic process involves catalyzing the oxidative opening of the purine ring during the...; Region: Uricase; cd00445
243230003612	tetramer interface [polypeptide binding]; other site
243230003613	active site
243230003614	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
243230003615	active site
243230003616	homotetramer interface [polypeptide binding]; other site
243230003617	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
243230003618	transcription elongation factor GreA; Region: greA; TIGR01462
243230003619	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
243230003620	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
243230003621	pilus retraction protein PilT; Region: pilT_fam; TIGR01420
243230003622	Walker A motif; other site
243230003623	ATP binding site [chemical binding]; other site
243230003624	Walker B motif; other site
243230003625	Pantoate-beta-alanine ligase; Region: PanC; cd00560
243230003626	active site
243230003627	ATP-binding site [chemical binding]; other site
243230003628	pantoate-binding site; other site
243230003629	HXXH motif; other site
243230003630	Predicted membrane protein [Function unknown]; Region: COG1950
243230003631	Fimbrial assembly protein (PilN); Region: PilN; cl19830
243230003632	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
243230003633	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
243230003634	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
243230003635	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
243230003636	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
243230003637	putative NADH binding site [chemical binding]; other site
243230003638	putative active site [active]
243230003639	nudix motif; other site
243230003640	putative metal binding site [ion binding]; other site
243230003641	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864
243230003642	Putative metallopeptidase domain; Region: DUF2201_N; pfam13203
243230003643	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
243230003644	enterobactin exporter EntS; Provisional; Region: PRK10489
243230003645	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243230003646	MoxR-like ATPases [General function prediction only]; Region: COG0714
243230003647	Walker A motif; other site
243230003648	ATP binding site [chemical binding]; other site
243230003649	Walker B motif; other site
243230003650	arginine finger; other site
243230003651	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
243230003652	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
243230003653	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
243230003654	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
243230003655	shikimate binding site; other site
243230003656	NAD(P) binding site [chemical binding]; other site
243230003657	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3614
243230003658	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243230003659	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
243230003660	putative active site [active]
243230003661	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243230003662	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
243230003663	putative active site [active]
243230003664	heme pocket [chemical binding]; other site
243230003665	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243230003666	putative active site [active]
243230003667	heme pocket [chemical binding]; other site
243230003668	GAF domain; Region: GAF_3; pfam13492
243230003669	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243230003670	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243230003671	dimer interface [polypeptide binding]; other site
243230003672	phosphorylation site [posttranslational modification]
243230003673	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243230003674	ATP binding site [chemical binding]; other site
243230003675	Mg2+ binding site [ion binding]; other site
243230003676	G-X-G motif; other site
243230003677	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243230003678	active site
243230003679	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243230003680	phosphorylation site [posttranslational modification]
243230003681	intermolecular recognition site; other site
243230003682	dimerization interface [polypeptide binding]; other site
243230003683	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243230003684	dimer interface [polypeptide binding]; other site
243230003685	phosphorylation site [posttranslational modification]
243230003686	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243230003687	ATP binding site [chemical binding]; other site
243230003688	Mg2+ binding site [ion binding]; other site
243230003689	G-X-G motif; other site
243230003690	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
243230003691	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
243230003692	Catalytic domain, repeat 1, of phospholipase D from Streptomyces Sp. Strain PMF and similar proteins; Region: PLDc_PMFPLD_like_1; cd09108
243230003693	domain interface [polypeptide binding]; other site
243230003694	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
243230003695	putative active site [active]
243230003696	catalytic site [active]
243230003697	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
243230003698	putative active site [active]
243230003699	catalytic site [active]
243230003700	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
243230003701	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
243230003702	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
243230003703	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230003704	Coenzyme A binding pocket [chemical binding]; other site
243230003705	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
243230003706	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333
243230003707	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
243230003708	homodimer interface [polypeptide binding]; other site
243230003709	metal binding site [ion binding]; metal-binding site
243230003710	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
243230003711	putative active site [active]
243230003712	putative CoA binding site [chemical binding]; other site
243230003713	nudix motif; other site
243230003714	metal binding site [ion binding]; metal-binding site
243230003715	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
243230003716	PEGA domain; Region: PEGA; pfam08308
243230003717	PEGA domain; Region: PEGA; pfam08308
243230003718	Cysteine-rich D. radiodurans N terminus; Region: CDRN; pfam05174
243230003719	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
243230003720	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
243230003721	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680
243230003722	Predicted integral membrane protein [Function unknown]; Region: COG3548
243230003723	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
243230003724	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
243230003725	metal binding triad [ion binding]; metal-binding site
243230003726	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
243230003727	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243230003728	Zn2+ binding site [ion binding]; other site
243230003729	Mg2+ binding site [ion binding]; other site
243230003730	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
243230003731	Uncharacterized conserved protein [Function unknown]; Region: COG4850
243230003732	Protein of unknown function (DUF1999); Region: DUF1999; pfam09390
243230003733	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
243230003734	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
243230003735	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
243230003736	G1 box; other site
243230003737	putative GEF interaction site [polypeptide binding]; other site
243230003738	GTP/Mg2+ binding site [chemical binding]; other site
243230003739	Switch I region; other site
243230003740	G2 box; other site
243230003741	G3 box; other site
243230003742	Switch II region; other site
243230003743	G4 box; other site
243230003744	G5 box; other site
243230003745	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
243230003746	Elongation Factor G, domain II; Region: EFG_II; pfam14492
243230003747	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
243230003748	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
243230003749	intracellular protease, PfpI family; Region: PfpI; TIGR01382
243230003750	proposed catalytic triad [active]
243230003751	conserved cys residue [active]
243230003752	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243230003753	TPR motif; other site
243230003754	binding surface
243230003755	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
243230003756	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
243230003757	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
243230003758	intersubunit interface [polypeptide binding]; other site
243230003759	active site
243230003760	catalytic residue [active]
243230003761	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
243230003762	active site
243230003763	dimer interface [polypeptide binding]; other site
243230003764	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
243230003765	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
243230003766	Ligand Binding Site [chemical binding]; other site
243230003767	TilS substrate C-terminal domain; Region: TilS_C; smart00977
243230003768	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
243230003769	nucleoside/Zn binding site; other site
243230003770	dimer interface [polypeptide binding]; other site
243230003771	catalytic motif [active]
243230003772	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
243230003773	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
243230003774	catalytic triad [active]
243230003775	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
243230003776	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
243230003777	catalytic triad [active]
243230003778	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
243230003779	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
243230003780	active site
243230003781	ATP binding site [chemical binding]; other site
243230003782	substrate binding site [chemical binding]; other site
243230003783	activation loop (A-loop); other site
243230003784	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
243230003785	Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777
243230003786	membrane glycoprotein; Provisional; Region: PHA03332
243230003787	Transcriptional regulator [Transcription]; Region: IclR; COG1414
243230003788	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
243230003789	Bacterial transcriptional regulator; Region: IclR; pfam01614
243230003790	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
243230003791	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
243230003792	G1 box; other site
243230003793	GTP/Mg2+ binding site [chemical binding]; other site
243230003794	Switch I region; other site
243230003795	G2 box; other site
243230003796	G3 box; other site
243230003797	Switch II region; other site
243230003798	G4 box; other site
243230003799	G5 box; other site
243230003800	Nucleoside recognition; Region: Gate; pfam07670
243230003801	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
243230003802	Nucleoside recognition; Region: Gate; pfam07670
243230003803	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
243230003804	Tetratricopeptide repeat; Region: TPR_12; pfam13424
243230003805	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
243230003806	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959
243230003807	NodB motif; other site
243230003808	putative active site [active]
243230003809	putative catalytic site [active]
243230003810	putative Zn binding site [ion binding]; other site
243230003811	Major Facilitator Superfamily; Region: MFS_1; pfam07690
243230003812	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243230003813	putative substrate translocation pore; other site
243230003814	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
243230003815	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
243230003816	active site
243230003817	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
243230003818	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
243230003819	putative ADP-binding pocket [chemical binding]; other site
243230003820	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
243230003821	PAS domain; Region: PAS; smart00091
243230003822	PAS domain; Region: PAS_9; pfam13426
243230003823	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
243230003824	Histidine kinase; Region: HisKA_3; pfam07730
243230003825	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243230003826	ATP binding site [chemical binding]; other site
243230003827	Mg2+ binding site [ion binding]; other site
243230003828	G-X-G motif; other site
243230003829	N-terminus of kinetochore NMS complex subunit Spc7; Region: Spc7_N; pfam15402
243230003830	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
243230003831	PilX N-terminal; Region: PilX_N; pfam14341
243230003832	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
243230003833	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
243230003834	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
243230003835	Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963
243230003836	Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
243230003837	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
243230003838	G1 box; other site
243230003839	GTP/Mg2+ binding site [chemical binding]; other site
243230003840	G2 box; other site
243230003841	Switch I region; other site
243230003842	G3 box; other site
243230003843	Switch II region; other site
243230003844	G4 box; other site
243230003845	G5 box; other site
243230003846	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
243230003847	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762
243230003848	Saccharomyces cerevisiae homocitrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_HCS; cd07948
243230003849	homocitrate synthase; Region: LysS_fung_arch; TIGR02146
243230003850	active site
243230003851	catalytic residues [active]
243230003852	metal binding site [ion binding]; metal-binding site
243230003853	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
243230003854	putative active site [active]
243230003855	putative catalytic site [active]
243230003856	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
243230003857	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
243230003858	PsbP; Region: PsbP; cl03356
243230003859	Catalytic domain of Protein Kinases; Region: PKc; cd00180
243230003860	active site
243230003861	ATP binding site [chemical binding]; other site
243230003862	substrate binding site [chemical binding]; other site
243230003863	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
243230003864	activation loop (A-loop); other site
243230003865	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
243230003866	DNA polymerase III, delta subunit; Region: holA; TIGR01128
243230003867	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
243230003868	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
243230003869	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
243230003870	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
243230003871	active site
243230003872	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
243230003873	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
243230003874	CoA-ligase; Region: Ligase_CoA; pfam00549
243230003875	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
243230003876	CoA binding domain; Region: CoA_binding; pfam02629
243230003877	CoA-ligase; Region: Ligase_CoA; pfam00549
243230003878	Protein of unknown function (DUF1553); Region: PSD1; pfam07587
243230003879	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
243230003880	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243230003881	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
243230003882	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
243230003883	FAD binding site [chemical binding]; other site
243230003884	homotetramer interface [polypeptide binding]; other site
243230003885	substrate binding pocket [chemical binding]; other site
243230003886	catalytic base [active]
243230003887	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
243230003888	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645
243230003889	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
243230003890	Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306
243230003891	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
243230003892	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
243230003893	putative Mg++ binding site [ion binding]; other site
243230003894	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243230003895	nucleotide binding region [chemical binding]; other site
243230003896	ATP-binding site [chemical binding]; other site
243230003897	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
243230003898	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
243230003899	active site
243230003900	metal binding site [ion binding]; metal-binding site
243230003901	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3798
243230003902	TROVE domain; Region: TROVE; pfam05731
243230003903	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236
243230003904	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
243230003905	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230003906	Coenzyme A binding pocket [chemical binding]; other site
243230003907	prolyl-tRNA synthetase; Provisional; Region: PRK08661
243230003908	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
243230003909	dimer interface [polypeptide binding]; other site
243230003910	motif 1; other site
243230003911	active site
243230003912	motif 2; other site
243230003913	motif 3; other site
243230003914	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
243230003915	anticodon binding site; other site
243230003916	zinc-binding site [ion binding]; other site
243230003917	Tetratrico peptide repeat; Region: TPR_5; pfam12688
243230003918	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
243230003919	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
243230003920	putative dimer interface [polypeptide binding]; other site
243230003921	putative anticodon binding site; other site
243230003922	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
243230003923	homodimer interface [polypeptide binding]; other site
243230003924	motif 1; other site
243230003925	motif 2; other site
243230003926	active site
243230003927	motif 3; other site
243230003928	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
243230003929	FMN binding site [chemical binding]; other site
243230003930	dimer interface [polypeptide binding]; other site
243230003931	Predicted membrane protein [Function unknown]; Region: COG4292
243230003932	Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14603
243230003933	RuvA N terminal domain; Region: RuvA_N; pfam01330
243230003934	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cd00080
243230003935	DNA binding site [nucleotide binding]
243230003936	metal binding site [ion binding]; metal-binding site
243230003937	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
243230003938	aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135
243230003939	seryl-tRNA synthetase; Provisional; Region: PRK05431
243230003940	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
243230003941	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
243230003942	dimer interface [polypeptide binding]; other site
243230003943	active site
243230003944	motif 1; other site
243230003945	motif 2; other site
243230003946	motif 3; other site
243230003947	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
243230003948	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243230003949	substrate binding pocket [chemical binding]; other site
243230003950	membrane-bound complex binding site; other site
243230003951	hinge residues; other site
243230003952	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
243230003953	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
243230003954	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
243230003955	superoxide dismutase; Provisional; Region: PRK10925
243230003956	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
243230003957	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
243230003958	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
243230003959	putative active site [active]
243230003960	metal binding site [ion binding]; metal-binding site
243230003961	homodimer binding site [polypeptide binding]; other site
243230003962	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
243230003963	DDE superfamily endonuclease; Region: DDE_5; cl17874
243230003964	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
243230003965	Uncharacterized conserved protein [Function unknown]; Region: COG2353
243230003966	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
243230003967	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
243230003968	ATP binding site [chemical binding]; other site
243230003969	putative Mg++ binding site [ion binding]; other site
243230003970	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243230003971	nucleotide binding region [chemical binding]; other site
243230003972	ATP-binding site [chemical binding]; other site
243230003973	RQC domain; Region: RQC; pfam09382
243230003974	HRDC domain; Region: HRDC; pfam00570
243230003975	HRDC domain; Region: HRDC; pfam00570
243230003976	HRDC domain; Region: HRDC; pfam00570
243230003977	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
243230003978	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
243230003979	peptide binding site [polypeptide binding]; other site
243230003980	D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327
243230003981	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
243230003982	ligand binding site [chemical binding]; other site
243230003983	NAD binding site [chemical binding]; other site
243230003984	dimerization interface [polypeptide binding]; other site
243230003985	catalytic site [active]
243230003986	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
243230003987	putative L-serine binding site [chemical binding]; other site
243230003988	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
243230003989	MPT binding site; other site
243230003990	trimer interface [polypeptide binding]; other site
243230003991	Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228
243230003992	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
243230003993	EamA-like transporter family; Region: EamA; pfam00892
243230003994	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
243230003995	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
243230003996	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
243230003997	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
243230003998	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
243230003999	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354
243230004000	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
243230004001	B12 binding site [chemical binding]; other site
243230004002	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243230004003	Radical SAM superfamily; Region: Radical_SAM; pfam04055
243230004004	FeS/SAM binding site; other site
243230004005	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
243230004006	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
243230004007	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243230004008	Walker A/P-loop; other site
243230004009	ATP binding site [chemical binding]; other site
243230004010	Q-loop/lid; other site
243230004011	ABC transporter signature motif; other site
243230004012	Walker B; other site
243230004013	D-loop; other site
243230004014	H-loop/switch region; other site
243230004015	TOBE domain; Region: TOBE_2; pfam08402
243230004016	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
243230004017	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243230004018	dimer interface [polypeptide binding]; other site
243230004019	conserved gate region; other site
243230004020	putative PBP binding loops; other site
243230004021	ABC-ATPase subunit interface; other site
243230004022	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
243230004023	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243230004024	dimer interface [polypeptide binding]; other site
243230004025	conserved gate region; other site
243230004026	putative PBP binding loops; other site
243230004027	ABC-ATPase subunit interface; other site
243230004028	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
243230004029	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243230004030	Major Facilitator Superfamily; Region: MFS_1; pfam07690
243230004031	putative substrate translocation pore; other site
243230004032	C-terminal peptidase (prc); Region: prc; TIGR00225
243230004033	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
243230004034	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
243230004035	Active site serine [active]
243230004036	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
243230004037	recombination regulator RecX; Provisional; Region: recX; PRK14137
243230004038	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
243230004039	active site
243230004040	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183
243230004041	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
243230004042	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
243230004043	tetramer interface [polypeptide binding]; other site
243230004044	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243230004045	catalytic residue [active]
243230004046	PRC-barrel domain; Region: PRC; pfam05239
243230004047	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861
243230004048	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861
243230004049	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
243230004050	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172
243230004051	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172
243230004052	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
243230004053	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
243230004054	active site
243230004055	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
243230004056	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
243230004057	Catalytic site [active]
243230004058	sugar efflux transporter; Region: 2A0120; TIGR00899
243230004059	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243230004060	putative substrate translocation pore; other site
243230004061	tRNA pseudouridine synthase B; Provisional; Region: PRK14122
243230004062	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
243230004063	RNA binding site [nucleotide binding]; other site
243230004064	active site
243230004065	H+ Antiporter protein; Region: 2A0121; TIGR00900
243230004066	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243230004067	putative substrate translocation pore; other site
243230004068	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
243230004069	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
243230004070	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
243230004071	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
243230004072	NlpC/P60 family; Region: NLPC_P60; pfam00877
243230004073	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
243230004074	Putative lysophospholipase; Region: Hydrolase_4; cl19140
243230004075	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243230004076	Major Facilitator Superfamily; Region: MFS_1; pfam07690
243230004077	putative substrate translocation pore; other site
243230004078	Predicted membrane protein [Function unknown]; Region: COG4828
243230004079	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
243230004080	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243230004081	active site
243230004082	motif I; other site
243230004083	motif II; other site
243230004084	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243230004085	Diaminopimelate epimerase; Region: DAP_epimerase; cl19724
243230004086	Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567
243230004087	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
243230004088	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
243230004089	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
243230004090	active site
243230004091	HIGH motif; other site
243230004092	nucleotide binding site [chemical binding]; other site
243230004093	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
243230004094	active site
243230004095	KMSKS motif; other site
243230004096	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
243230004097	tRNA binding surface [nucleotide binding]; other site
243230004098	anticodon binding site; other site
243230004099	Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
243230004100	Benzoate membrane transport protein; Region: BenE; pfam03594
243230004101	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
243230004102	active site
243230004103	intersubunit interactions; other site
243230004104	catalytic residue [active]
243230004105	transcription termination factor Rho; Provisional; Region: rho; PRK09376
243230004106	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
243230004107	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
243230004108	RNA binding site [nucleotide binding]; other site
243230004109	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
243230004110	multimer interface [polypeptide binding]; other site
243230004111	Walker A motif; other site
243230004112	ATP binding site [chemical binding]; other site
243230004113	Walker B motif; other site
243230004114	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
243230004115	substrate binding site [chemical binding]; other site
243230004116	dimer interface [polypeptide binding]; other site
243230004117	catalytic triad [active]
243230004118	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
243230004119	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
243230004120	dimer interface [polypeptide binding]; other site
243230004121	ligand binding site [chemical binding]; other site
243230004122	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
243230004123	substrate binding site [chemical binding]; other site
243230004124	hinge regions; other site
243230004125	ADP binding site [chemical binding]; other site
243230004126	catalytic site [active]
243230004127	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
243230004128	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
243230004129	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
243230004130	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
243230004131	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
243230004132	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243230004133	motif II; other site
243230004134	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
243230004135	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
243230004136	active site
243230004137	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
243230004138	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
243230004139	dimer interface [polypeptide binding]; other site
243230004140	anticodon binding site; other site
243230004141	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
243230004142	homodimer interface [polypeptide binding]; other site
243230004143	motif 1; other site
243230004144	active site
243230004145	motif 2; other site
243230004146	GAD domain; Region: GAD; pfam02938
243230004147	motif 3; other site
243230004148	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3798
243230004149	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
243230004150	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
243230004151	dimer interface [polypeptide binding]; other site
243230004152	motif 1; other site
243230004153	active site
243230004154	motif 2; other site
243230004155	motif 3; other site
243230004156	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
243230004157	anticodon binding site; other site
243230004158	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
243230004159	homodimer interface [polypeptide binding]; other site
243230004160	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243230004161	catalytic residue [active]
243230004162	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
243230004163	Putative lysophospholipase; Region: Hydrolase_4; cl19140
243230004164	Putative lysophospholipase; Region: Hydrolase_4; cl19140
243230004165	Putative lysophospholipase; Region: Hydrolase_4; cl19140
243230004166	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
243230004167	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
243230004168	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
243230004169	putative active site [active]
243230004170	catalytic triad [active]
243230004171	putative dimer interface [polypeptide binding]; other site
243230004172	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
243230004173	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
243230004174	GIY-YIG motif/motif A; other site
243230004175	active site
243230004176	catalytic site [active]
243230004177	putative DNA binding site [nucleotide binding]; other site
243230004178	metal binding site [ion binding]; metal-binding site
243230004179	UvrB/uvrC motif; Region: UVR; pfam02151
243230004180	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
243230004181	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
243230004182	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
243230004183	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
243230004184	active site
243230004185	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
243230004186	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
243230004187	Walker A/P-loop; other site
243230004188	ATP binding site [chemical binding]; other site
243230004189	Q-loop/lid; other site
243230004190	ABC transporter signature motif; other site
243230004191	Walker B; other site
243230004192	D-loop; other site
243230004193	H-loop/switch region; other site
243230004194	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243230004195	dimer interface [polypeptide binding]; other site
243230004196	conserved gate region; other site
243230004197	ABC-ATPase subunit interface; other site
243230004198	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
243230004199	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
243230004200	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
243230004201	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
243230004202	active site
243230004203	metal binding site [ion binding]; metal-binding site
243230004204	Bacterial SH3 domain; Region: SH3_3; pfam08239
243230004205	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
243230004206	NlpC/P60 family; Region: NLPC_P60; pfam00877
243230004207	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
243230004208	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
243230004209	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
243230004210	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
243230004211	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
243230004212	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
243230004213	aspartate kinase; Provisional; Region: PRK06291
243230004214	AAK_AK-LysC-like: Amino Acid Kinase Superfamily (AAK), AK-LysC-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive AK isoenzyme found in higher plants. The lysine-sensitive AK isoenzyme is a monofunctional...; Region: AAK_AK-LysC-like; cd04244
243230004215	putative catalytic residues [active]
243230004216	putative nucleotide binding site [chemical binding]; other site
243230004217	aspartate binding site [chemical binding]; other site
243230004218	dimer interface [polypeptide binding]; other site
243230004219	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
243230004220	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
243230004221	predicted active site [active]
243230004222	catalytic triad [active]
243230004223	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
243230004224	active site
243230004225	multimer interface [polypeptide binding]; other site
243230004226	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
243230004227	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
243230004228	catalytic residue [active]
243230004229	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
243230004230	DivIVA protein; Region: DivIVA; pfam05103
243230004231	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
243230004232	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
243230004233	Water Stress and Hypersensitive response; Region: WHy; smart00769
243230004234	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
243230004235	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
243230004236	cobalamin binding residues [chemical binding]; other site
243230004237	putative BtuC binding residues; other site
243230004238	dimer interface [polypeptide binding]; other site
243230004239	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
243230004240	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
243230004241	active site
243230004242	interdomain interaction site; other site
243230004243	putative metal-binding site [ion binding]; other site
243230004244	nucleotide binding site [chemical binding]; other site
243230004245	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
243230004246	domain I; other site
243230004247	DNA binding groove [nucleotide binding]
243230004248	phosphate binding site [ion binding]; other site
243230004249	domain II; other site
243230004250	domain III; other site
243230004251	nucleotide binding site [chemical binding]; other site
243230004252	catalytic site [active]
243230004253	domain IV; other site
243230004254	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
243230004255	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
243230004256	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
243230004257	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331
243230004258	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
243230004259	active site
243230004260	catalytic site [active]
243230004261	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
243230004262	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
243230004263	active site
243230004264	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
243230004265	methionine sulfoxide reductase B; Provisional; Region: PRK00222
243230004266	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243230004267	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
243230004268	Protein of unknown function (DUF981); Region: DUF981; pfam06168
243230004269	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
243230004270	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
243230004271	Probable transposase; Region: OrfB_IS605; pfam01385
243230004272	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
243230004273	Transposase IS200 like; Region: Y1_Tnp; pfam01797
243230004274	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243230004275	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
243230004276	Predicted outer membrane protein [Function unknown]; Region: COG3652
243230004277	GTP-binding protein YchF; Reviewed; Region: PRK09601
243230004278	YchF GTPase; Region: YchF; cd01900
243230004279	G1 box; other site
243230004280	GTP/Mg2+ binding site [chemical binding]; other site
243230004281	Switch I region; other site
243230004282	G2 box; other site
243230004283	Switch II region; other site
243230004284	G3 box; other site
243230004285	G4 box; other site
243230004286	G5 box; other site
243230004287	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
243230004288	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
243230004289	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
243230004290	active site
243230004291	metal binding site [ion binding]; metal-binding site
243230004292	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243230004293	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
243230004294	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
243230004295	active site
243230004296	Uncharacterized conserved protein [Function unknown]; Region: COG3358
243230004297	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
243230004298	RNA binding surface [nucleotide binding]; other site
243230004299	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
243230004300	catalytic core [active]
243230004301	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
243230004302	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
243230004303	dimerization interface [polypeptide binding]; other site
243230004304	putative ATP binding site [chemical binding]; other site
243230004305	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
243230004306	substrate binding pocket [chemical binding]; other site
243230004307	chain length determination region; other site
243230004308	substrate-Mg2+ binding site; other site
243230004309	catalytic residues [active]
243230004310	aspartate-rich region 1; other site
243230004311	active site lid residues [active]
243230004312	aspartate-rich region 2; other site
243230004313	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
243230004314	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230004315	Coenzyme A binding pocket [chemical binding]; other site
243230004316	N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741
243230004317	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
243230004318	dimer interface [polypeptide binding]; other site
243230004319	FMN binding site [chemical binding]; other site
243230004320	NADPH bind site [chemical binding]; other site
243230004321	2-phosphosulfolactate phosphatase; Provisional; Region: PRK14100
243230004322	Cysteine-rich D. radiodurans N terminus; Region: CDRN; pfam05174
243230004323	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
243230004324	substrate binding site [chemical binding]; other site
243230004325	hexamer interface [polypeptide binding]; other site
243230004326	metal binding site [ion binding]; metal-binding site
243230004327	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243230004328	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
243230004329	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
243230004330	Putative lysophospholipase; Region: Hydrolase_4; cl19140
243230004331	Putative lysophospholipase; Region: Hydrolase_4; cl19140
243230004332	Putative Ig domain; Region: He_PIG; pfam05345
243230004333	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
243230004334	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
243230004335	dimer interface [polypeptide binding]; other site
243230004336	active site
243230004337	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
243230004338	catalytic residues [active]
243230004339	substrate binding site [chemical binding]; other site
243230004340	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
243230004341	transmembrane helices; other site
243230004342	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
243230004343	TrkA-C domain; Region: TrkA_C; pfam02080
243230004344	TrkA-C domain; Region: TrkA_C; pfam02080
243230004345	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
243230004346	acetyl-lysine deacetylase; Provisional; Region: PRK04443
243230004347	M20 Peptidase acetylornithine deacetylase/acetyl-lysine deacetylase; Region: M20_ArgE_LysK; cd05653
243230004348	metal binding site [ion binding]; metal-binding site
243230004349	putative dimer interface [polypeptide binding]; other site
243230004350	large tegument protein UL36; Provisional; Region: PHA03247
243230004351	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
243230004352	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
243230004353	inhibitor-cofactor binding pocket; inhibition site
243230004354	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243230004355	catalytic residue [active]
243230004356	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
243230004357	Transglycosylase; Region: Transgly; pfam00912
243230004358	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
243230004359	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
243230004360	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243230004361	active site
243230004362	phosphorylation site [posttranslational modification]
243230004363	intermolecular recognition site; other site
243230004364	dimerization interface [polypeptide binding]; other site
243230004365	AAA domain; Region: AAA_33; pfam13671
243230004366	AAA domain; Region: AAA_18; pfam13238
243230004367	AAK_NAGK-UC: N-Acetyl-L-glutamate kinase - uncharacterized (NAGK-UC). This domain is similar to Escherichia coli and Pseudomonas aeruginosa NAGKs which catalyze the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the...; Region: AAK_NAGK-UC; cd04251
243230004368	putative nucleotide binding site [chemical binding]; other site
243230004369	putative N-acetyl-L-glutamate binding site [chemical binding]; other site
243230004370	TFIIE alpha subunit; Region: TFIIE_alpha; pfam02002
243230004371	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870
243230004372	chaperone protein DnaJ; Provisional; Region: PRK14292
243230004373	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
243230004374	HSP70 interaction site [polypeptide binding]; other site
243230004375	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
243230004376	Zn binding sites [ion binding]; other site
243230004377	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
243230004378	dimer interface [polypeptide binding]; other site
243230004379	Predicted secreted protein [Function unknown]; Region: COG5497
243230004380	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
243230004381	active site
243230004382	ribulose/triose binding site [chemical binding]; other site
243230004383	phosphate binding site [ion binding]; other site
243230004384	substrate (anthranilate) binding pocket [chemical binding]; other site
243230004385	product (indole) binding pocket [chemical binding]; other site
243230004386	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
243230004387	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
243230004388	Catalytic site [active]
243230004389	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
243230004390	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
243230004391	dimer interface [polypeptide binding]; other site
243230004392	active site
243230004393	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
243230004394	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
243230004395	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
243230004396	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
243230004397	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
243230004398	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
243230004399	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
243230004400	active site
243230004401	HIGH motif; other site
243230004402	KMSKS motif; other site
243230004403	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
243230004404	tRNA binding surface [nucleotide binding]; other site
243230004405	anticodon binding site; other site
243230004406	HMG14 and HMG17; Region: HMG14_17; pfam01101
243230004407	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
243230004408	dimer interface [polypeptide binding]; other site
243230004409	putative tRNA-binding site [nucleotide binding]; other site
243230004410	Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660
243230004411	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
243230004412	phosphate binding site [ion binding]; other site
243230004413	putative substrate binding pocket [chemical binding]; other site
243230004414	dimer interface [polypeptide binding]; other site
243230004415	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
243230004416	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243230004417	dimer interface [polypeptide binding]; other site
243230004418	conserved gate region; other site
243230004419	putative PBP binding loops; other site
243230004420	ABC-ATPase subunit interface; other site
243230004421	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
243230004422	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243230004423	dimer interface [polypeptide binding]; other site
243230004424	conserved gate region; other site
243230004425	putative PBP binding loops; other site
243230004426	ABC-ATPase subunit interface; other site
243230004427	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
243230004428	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
243230004429	Haem-binding domain; Region: Haem_bd; pfam14376
243230004430	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
243230004431	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
243230004432	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839
243230004433	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
243230004434	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
243230004435	HD supefamily hydrolase [General function prediction only]; Region: COG3294
243230004436	ATP phosphoribosyltransferase involved in histidine biosynthesis [Amino acid transport and metabolism]; Region: HisZ; COG3705
243230004437	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
243230004438	dimer interface [polypeptide binding]; other site
243230004439	motif 1; other site
243230004440	active site
243230004441	motif 2; other site
243230004442	motif 3; other site
243230004443	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
243230004444	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
243230004445	Domain of unknown function (DUF4493); Region: DUF4493; pfam14900
243230004446	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
243230004447	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
243230004448	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
243230004449	putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350
243230004450	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243230004451	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243230004452	homodimer interface [polypeptide binding]; other site
243230004453	catalytic residue [active]
243230004454	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
243230004455	Helix-turn-helix domain; Region: HTH_17; pfam12728
243230004456	ribose-phosphate pyrophosphokinase; Region: ribP_PPkin; TIGR01251
243230004457	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
243230004458	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
243230004459	active site
243230004460	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
243230004461	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
243230004462	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
243230004463	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
243230004464	Subtilase family; Region: Peptidase_S8; pfam00082
243230004465	active site
243230004466	catalytic residues [active]
243230004467	Family of unknown function (DUF490); Region: DUF490; pfam04357
243230004468	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
243230004469	Family of unknown function (DUF490); Region: DUF490; pfam04357
243230004470	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
243230004471	short chain dehydrogenase; Provisional; Region: PRK07326
243230004472	classical (c) SDR, subgroup 4; Region: SDR_c4; cd08929
243230004473	putative NAD(P) binding site [chemical binding]; other site
243230004474	homodimer interface [polypeptide binding]; other site
243230004475	active site
243230004476	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
243230004477	SmpB-tmRNA interface; other site
243230004478	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
243230004479	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713
243230004480	active site
243230004481	Sporulation and spore germination; Region: Germane; pfam10646
243230004482	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
243230004483	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470
243230004484	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
243230004485	ABC transporter signature motif; other site
243230004486	Walker B; other site
243230004487	D-loop; other site
243230004488	H-loop/switch region; other site
243230004489	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
243230004490	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
243230004491	active site
243230004492	catalytic site [active]
243230004493	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
243230004494	PspA/IM30 family; Region: PspA_IM30; pfam04012
243230004495	Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154
243230004496	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
243230004497	TPP-binding site; other site
243230004498	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
243230004499	PYR/PP interface [polypeptide binding]; other site
243230004500	dimer interface [polypeptide binding]; other site
243230004501	TPP binding site [chemical binding]; other site
243230004502	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
243230004503	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
243230004504	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
243230004505	Walker A/P-loop; other site
243230004506	ATP binding site [chemical binding]; other site
243230004507	Q-loop/lid; other site
243230004508	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
243230004509	ABC transporter signature motif; other site
243230004510	Walker B; other site
243230004511	D-loop; other site
243230004512	H-loop/switch region; other site
243230004513	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550
243230004514	Heavy-metal-associated domain; Region: HMA; pfam00403
243230004515	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
243230004516	envelope glycoprotein C; Provisional; Region: PHA03269
243230004517	Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253
243230004518	2-isopropylmalate synthase; Validated; Region: PRK00915
243230004519	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
243230004520	active site
243230004521	catalytic residues [active]
243230004522	metal binding site [ion binding]; metal-binding site
243230004523	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
243230004524	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
243230004525	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
243230004526	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
243230004527	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
243230004528	substrate binding site [chemical binding]; other site
243230004529	oxyanion hole (OAH) forming residues; other site
243230004530	trimer interface [polypeptide binding]; other site
243230004531	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
243230004532	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
243230004533	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
243230004534	Transcriptional regulator [Transcription]; Region: LytR; COG1316
243230004535	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
243230004536	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
243230004537	NAD(P) binding site [chemical binding]; other site
243230004538	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
243230004539	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
243230004540	protein binding site [polypeptide binding]; other site
243230004541	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
243230004542	Active site serine [active]
243230004543	proton-translocating NADH-quinone oxidoreductase, chain N; Region: NDH_I_N; TIGR01770
243230004544	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
243230004545	proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972
243230004546	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
243230004547	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
243230004548	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
243230004549	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
243230004550	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
243230004551	NADH-ubiquinone/plastoquinone oxidoreductase chain 6; Region: Oxidored_q3; cl17265
243230004552	Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143
243230004553	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
243230004554	NADH:ubiquinone oxidoreductase subunit 1 (chain H) [Energy production and conversion]; Region: NuoH; COG1005
243230004555	NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973
243230004556	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
243230004557	catalytic loop [active]
243230004558	iron binding site [ion binding]; other site
243230004559	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
243230004560	MopB_NADH-Q-OR-NuoG2: The NuoG/Nad11/75-kDa subunit (second domain) of the NADH-quinone oxidoreductase (NADH-Q-OR)/respiratory complex I/NADH dehydrogenase-1 (NDH-1). The NADH-Q-OR is the first energy-transducting complex in the respiratory chains of...; Region: MopB_NADH-Q-OR-NuoG2; cd02768
243230004561	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
243230004562	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
243230004563	SLBB domain; Region: SLBB; pfam10531
243230004564	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
243230004565	NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958
243230004566	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
243230004567	putative dimer interface [polypeptide binding]; other site
243230004568	[2Fe-2S] cluster binding site [ion binding]; other site
243230004569	NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962
243230004570	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
243230004571	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
243230004572	NADH dehydrogenase subunit B; Validated; Region: PRK06411
243230004573	NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; Region: NuoA; COG0838
243230004574	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
243230004575	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
243230004576	active site
243230004577	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
243230004578	protein binding site [polypeptide binding]; other site
243230004579	putative substrate binding region [chemical binding]; other site
243230004580	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
243230004581	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
243230004582	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
243230004583	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
243230004584	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
243230004585	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
243230004586	hinge region; other site
243230004587	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
243230004588	putative nucleotide binding site [chemical binding]; other site
243230004589	uridine monophosphate binding site [chemical binding]; other site
243230004590	homohexameric interface [polypeptide binding]; other site
243230004591	elongation factor Ts; Provisional; Region: tsf; PRK09377
243230004592	UBA/TS-N domain; Region: UBA; pfam00627
243230004593	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
243230004594	rRNA interaction site [nucleotide binding]; other site
243230004595	S8 interaction site; other site
243230004596	putative laminin-1 binding site; other site
243230004597	2-phosphoglycerate kinase; Provisional; Region: PRK12337
243230004598	ATP cone domain; Region: ATP-cone; pfam03477
243230004599	ATP cone domain; Region: ATP-cone; pfam03477
243230004600	AAA domain; Region: AAA_17; cl19128
243230004601	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
243230004602	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
243230004603	PYR/PP interface [polypeptide binding]; other site
243230004604	dimer interface [polypeptide binding]; other site
243230004605	TPP binding site [chemical binding]; other site
243230004606	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
243230004607	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
243230004608	TPP-binding site [chemical binding]; other site
243230004609	dimer interface [polypeptide binding]; other site
243230004610	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
243230004611	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
243230004612	putative valine binding site [chemical binding]; other site
243230004613	dimer interface [polypeptide binding]; other site
243230004614	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
243230004615	ketol-acid reductoisomerase; Provisional; Region: PRK05479
243230004616	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
243230004617	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
243230004618	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
243230004619	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
243230004620	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243230004621	S-adenosylmethionine binding site [chemical binding]; other site
243230004622	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126
243230004623	pyrroline-5-carboxylate reductase; Region: proC; TIGR00112
243230004624	Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748
243230004625	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
243230004626	Winged helix-turn helix; Region: HTH_33; pfam13592
243230004627	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
243230004628	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
243230004629	substrate binding site [chemical binding]; other site
243230004630	ATP binding site [chemical binding]; other site
243230004631	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243230004632	S-adenosylmethionine binding site [chemical binding]; other site
243230004633	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243230004634	TPR motif; other site
243230004635	binding surface
243230004636	Uncharacterized conserved protein [Function unknown]; Region: COG0062
243230004637	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
243230004638	putative substrate binding site [chemical binding]; other site
243230004639	putative ATP binding site [chemical binding]; other site
243230004640	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875
243230004641	putative active site [active]
243230004642	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
243230004643	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
243230004644	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
243230004645	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
243230004646	ATP binding site [chemical binding]; other site
243230004647	putative Mg++ binding site [ion binding]; other site
243230004648	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243230004649	nucleotide binding region [chemical binding]; other site
243230004650	ATP-binding site [chemical binding]; other site
243230004651	TRCF domain; Region: TRCF; pfam03461
243230004652	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440
243230004653	SET and RING finger associated domain; Region: SRA; smart00466
243230004654	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
243230004655	active site
243230004656	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
243230004657	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230004658	Coenzyme A binding pocket [chemical binding]; other site
243230004659	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
243230004660	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
243230004661	Subtilase family; Region: Peptidase_S8; pfam00082
243230004662	active site
243230004663	catalytic residues [active]
243230004664	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
243230004665	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
243230004666	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187
243230004667	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
243230004668	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
243230004669	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
243230004670	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
243230004671	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172
243230004672	AAA domain; Region: AAA_17; cl19128
243230004673	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
243230004674	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
243230004675	active site
243230004676	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
243230004677	E-class dimer interface [polypeptide binding]; other site
243230004678	P-class dimer interface [polypeptide binding]; other site
243230004679	active site
243230004680	Cu2+ binding site [ion binding]; other site
243230004681	Zn2+ binding site [ion binding]; other site
243230004682	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
243230004683	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
243230004684	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
243230004685	Uncharacterized conserved protein (DUF2203); Region: DUF2203; cl02056
243230004686	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
243230004687	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
243230004688	Peptidase family M23; Region: Peptidase_M23; pfam01551
243230004689	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
243230004690	ATP-binding cassette domain of the cell division transporter; Region: ABC_FtsE_transporter; cd03292
243230004691	Walker A/P-loop; other site
243230004692	ATP binding site [chemical binding]; other site
243230004693	Q-loop/lid; other site
243230004694	ABC transporter signature motif; other site
243230004695	Walker B; other site
243230004696	D-loop; other site
243230004697	H-loop/switch region; other site
243230004698	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
243230004699	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
243230004700	C-terminal peptidase (prc); Region: prc; TIGR00225
243230004701	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
243230004702	protein binding site [polypeptide binding]; other site
243230004703	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
243230004704	Catalytic dyad [active]
243230004705	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
243230004706	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
243230004707	G1 box; other site
243230004708	putative GEF interaction site [polypeptide binding]; other site
243230004709	GTP/Mg2+ binding site [chemical binding]; other site
243230004710	Switch I region; other site
243230004711	G2 box; other site
243230004712	G3 box; other site
243230004713	Switch II region; other site
243230004714	G4 box; other site
243230004715	G5 box; other site
243230004716	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
243230004717	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307
243230004718	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
243230004719	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
243230004720	Putative sensor; Region: Sensor; pfam13796
243230004721	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
243230004722	Histidine kinase; Region: HisKA_3; pfam07730
243230004723	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243230004724	ATP binding site [chemical binding]; other site
243230004725	Mg2+ binding site [ion binding]; other site
243230004726	G-X-G motif; other site
243230004727	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
243230004728	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
243230004729	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243230004730	active site
243230004731	phosphorylation site [posttranslational modification]
243230004732	intermolecular recognition site; other site
243230004733	dimerization interface [polypeptide binding]; other site
243230004734	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
243230004735	DNA binding residues [nucleotide binding]
243230004736	dimerization interface [polypeptide binding]; other site
243230004737	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
243230004738	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
243230004739	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
243230004740	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
243230004741	active site
243230004742	homodimer interface [polypeptide binding]; other site
243230004743	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
243230004744	Mg++ binding site [ion binding]; other site
243230004745	putative catalytic motif [active]
243230004746	substrate binding site [chemical binding]; other site
243230004747	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
243230004748	active site
243230004749	Phosphotransferase enzyme family; Region: APH; pfam01636
243230004750	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
243230004751	active site
243230004752	substrate binding site [chemical binding]; other site
243230004753	ATP binding site [chemical binding]; other site
243230004754	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
243230004755	GAF domain; Region: GAF_3; pfam13492
243230004756	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243230004757	Zn2+ binding site [ion binding]; other site
243230004758	Mg2+ binding site [ion binding]; other site
243230004759	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
243230004760	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
243230004761	Walker A/P-loop; other site
243230004762	ATP binding site [chemical binding]; other site
243230004763	Q-loop/lid; other site
243230004764	ABC transporter signature motif; other site
243230004765	Walker B; other site
243230004766	D-loop; other site
243230004767	H-loop/switch region; other site
243230004768	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
243230004769	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
243230004770	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
243230004771	Walker A/P-loop; other site
243230004772	ATP binding site [chemical binding]; other site
243230004773	Q-loop/lid; other site
243230004774	ABC transporter signature motif; other site
243230004775	Walker B; other site
243230004776	D-loop; other site
243230004777	H-loop/switch region; other site
243230004778	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
243230004779	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
243230004780	dipeptide transporter; Provisional; Region: PRK10913
243230004781	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243230004782	dimer interface [polypeptide binding]; other site
243230004783	conserved gate region; other site
243230004784	putative PBP binding loops; other site
243230004785	ABC-ATPase subunit interface; other site
243230004786	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
243230004787	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243230004788	dimer interface [polypeptide binding]; other site
243230004789	conserved gate region; other site
243230004790	putative PBP binding loops; other site
243230004791	ABC-ATPase subunit interface; other site
243230004792	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
243230004793	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
243230004794	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
243230004795	CTP synthetase; Validated; Region: pyrG; PRK05380
243230004796	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
243230004797	Catalytic site [active]
243230004798	active site
243230004799	UTP binding site [chemical binding]; other site
243230004800	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
243230004801	active site
243230004802	putative oxyanion hole; other site
243230004803	catalytic triad [active]
243230004804	Phosphatidylserine decarboxylase [Lipid metabolism]; Region: Psd; COG0688
243230004805	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
243230004806	Uncharacterized conserved protein [Function unknown]; Region: COG1432
243230004807	LabA_like proteins; Region: LabA; cd10911
243230004808	putative metal binding site [ion binding]; other site
243230004809	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
243230004810	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243230004811	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243230004812	homodimer interface [polypeptide binding]; other site
243230004813	catalytic residue [active]
243230004814	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
243230004815	active site
243230004816	metal binding site [ion binding]; metal-binding site
243230004817	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
243230004818	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243230004819	Walker A/P-loop; other site
243230004820	ATP binding site [chemical binding]; other site
243230004821	Q-loop/lid; other site
243230004822	ABC transporter signature motif; other site
243230004823	Walker B; other site
243230004824	D-loop; other site
243230004825	H-loop/switch region; other site
243230004826	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
243230004827	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
243230004828	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694
243230004829	ribonuclease PH; Reviewed; Region: rph; PRK00173
243230004830	Ribonuclease PH; Region: RNase_PH_bact; cd11362
243230004831	hexamer interface [polypeptide binding]; other site
243230004832	active site
243230004833	glutamate racemase; Provisional; Region: PRK00865
243230004834	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533
243230004835	homodimer interface [polypeptide binding]; other site
243230004836	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
243230004837	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243230004838	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243230004839	homodimer interface [polypeptide binding]; other site
243230004840	catalytic residue [active]
243230004841	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
243230004842	intersubunit interface [polypeptide binding]; other site
243230004843	active site
243230004844	zinc binding site [ion binding]; other site
243230004845	Na+ binding site [ion binding]; other site
243230004846	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
243230004847	Hypothetical protein TTHB210, a sigma(E)-regulated gene product found in Thermus thermophilus, and similar proteins; Region: TTHB210-like; cd11669
243230004848	oligomer interface [polypeptide binding]; other site
243230004849	Transposase IS200 like; Region: Y1_Tnp; pfam01797
243230004850	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
243230004851	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
243230004852	Probable transposase; Region: OrfB_IS605; pfam01385
243230004853	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
243230004854	Fimbrial, major and minor subunit; Region: Fimbrial_K88; pfam02432
243230004855	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
243230004856	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
243230004857	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
243230004858	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
243230004859	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
243230004860	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
243230004861	Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429
243230004862	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
243230004863	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
243230004864	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
243230004865	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
243230004866	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
243230004867	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
243230004868	Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356
243230004869	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
243230004870	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
243230004871	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
243230004872	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959
243230004873	NodB motif; other site
243230004874	putative active site [active]
243230004875	putative catalytic site [active]
243230004876	putative Zn binding site [ion binding]; other site
243230004877	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
243230004878	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243230004879	active site
243230004880	phosphorylation site [posttranslational modification]
243230004881	intermolecular recognition site; other site
243230004882	dimerization interface [polypeptide binding]; other site
243230004883	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
243230004884	DNA binding site [nucleotide binding]
243230004885	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243230004886	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243230004887	dimerization interface [polypeptide binding]; other site
243230004888	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243230004889	dimer interface [polypeptide binding]; other site
243230004890	phosphorylation site [posttranslational modification]
243230004891	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243230004892	ATP binding site [chemical binding]; other site
243230004893	Mg2+ binding site [ion binding]; other site
243230004894	G-X-G motif; other site
243230004895	DinB superfamily; Region: DinB_2; pfam12867
243230004896	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
243230004897	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
243230004898	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
243230004899	homoaconitate hydratase family protein; Region: hacA_fam; TIGR01343
243230004900	substrate binding site [chemical binding]; other site
243230004901	ligand binding site [chemical binding]; other site
243230004902	V4R domain; Region: V4R; cl15268
243230004903	Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018
243230004904	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
243230004905	dimerization interface [polypeptide binding]; other site
243230004906	putative DNA binding site [nucleotide binding]; other site
243230004907	putative Zn2+ binding site [ion binding]; other site
243230004908	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
243230004909	substrate binding site [chemical binding]; other site
243230004910	Predicted membrane protein [Function unknown]; Region: COG4371
243230004911	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
243230004912	active site
243230004913	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
243230004914	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
243230004915	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
243230004916	Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720
243230004917	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
243230004918	VanW like protein; Region: VanW; pfam04294
243230004919	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
243230004920	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243230004921	NAD(P) binding site [chemical binding]; other site
243230004922	active site
243230004923	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
243230004924	nucleotide binding site/active site [active]
243230004925	HIT family signature motif; other site
243230004926	catalytic residue [active]
243230004927	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243230004928	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
243230004929	active site
243230004930	motif I; other site
243230004931	motif II; other site
243230004932	PrcB C-terminal; Region: PrcB_C; pfam14343
243230004933	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
243230004934	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
243230004935	putative Mg++ binding site [ion binding]; other site
243230004936	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243230004937	nucleotide binding region [chemical binding]; other site
243230004938	ATP-binding site [chemical binding]; other site
243230004939	RNA-binding GUCT-like domain found in Thermus thermophilus heat resistant RNA-dependent ATPase (Hera) and similar proteins; Region: GUCT_Hera; cd12938
243230004940	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951
243230004941	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
243230004942	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
243230004943	homodimer interface [polypeptide binding]; other site
243230004944	substrate-cofactor binding pocket; other site
243230004945	catalytic residue [active]
243230004946	oligoendopeptidase F; Region: pepF; TIGR00181
243230004947	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
243230004948	active site
243230004949	Zn binding site [ion binding]; other site
243230004950	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
243230004951	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
243230004952	DNA binding residues [nucleotide binding]
243230004953	dimer interface [polypeptide binding]; other site
243230004954	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
243230004955	Tetratricopeptide repeat; Region: TPR_12; pfam13424
243230004956	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243230004957	binding surface
243230004958	TPR motif; other site
243230004959	Tetratricopeptide repeat; Region: TPR_12; pfam13424
243230004960	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243230004961	metal binding site [ion binding]; metal-binding site
243230004962	active site
243230004963	I-site; other site
243230004964	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243230004965	Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811
243230004966	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
243230004967	synthetase active site [active]
243230004968	NTP binding site [chemical binding]; other site
243230004969	metal binding site [ion binding]; metal-binding site
243230004970	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
243230004971	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
243230004972	active site
243230004973	metal binding site [ion binding]; metal-binding site
243230004974	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
243230004975	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243230004976	metal binding site [ion binding]; metal-binding site
243230004977	active site
243230004978	I-site; other site
243230004979	FecR protein; Region: FecR; pfam04773
243230004980	FixH; Region: FixH; cl19376
243230004981	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
243230004982	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
243230004983	ABC transporter; Region: ABC_tran_2; pfam12848
243230004984	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
243230004985	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
243230004986	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
243230004987	ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636
243230004988	DinB superfamily; Region: DinB_2; pfam12867
243230004989	DinB superfamily; Region: DinB_2; pfam12867
243230004990	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
243230004991	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
243230004992	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
243230004993	ligand binding site [chemical binding]; other site
243230004994	flexible hinge region; other site
243230004995	non-specific DNA interactions [nucleotide binding]; other site
243230004996	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
243230004997	DNA binding site [nucleotide binding]
243230004998	sequence specific DNA binding site [nucleotide binding]; other site
243230004999	putative cAMP binding site [chemical binding]; other site
243230005000	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
243230005001	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
243230005002	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
243230005003	Walker A/P-loop; other site
243230005004	ATP binding site [chemical binding]; other site
243230005005	Q-loop/lid; other site
243230005006	ABC transporter signature motif; other site
243230005007	Walker B; other site
243230005008	D-loop; other site
243230005009	H-loop/switch region; other site
243230005010	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
243230005011	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
243230005012	TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666
243230005013	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
243230005014	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
243230005015	Probable transposase; Region: OrfB_IS605; pfam01385
243230005016	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
243230005017	Transposase IS200 like; Region: Y1_Tnp; pfam01797
243230005018	TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666
243230005019	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
243230005020	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
243230005021	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243230005022	substrate binding pocket [chemical binding]; other site
243230005023	membrane-bound complex binding site; other site
243230005024	hinge residues; other site
243230005025	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
243230005026	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
243230005027	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243230005028	Walker A motif; other site
243230005029	ATP binding site [chemical binding]; other site
243230005030	Walker B motif; other site
243230005031	arginine finger; other site
243230005032	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
243230005033	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
243230005034	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
243230005035	active site
243230005036	Zn binding site [ion binding]; other site
243230005037	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
243230005038	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
243230005039	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
243230005040	NAD(P) binding site [chemical binding]; other site
243230005041	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
243230005042	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
243230005043	TrkA-N domain; Region: TrkA_N; pfam02254
243230005044	TrkA-C domain; Region: TrkA_C; pfam02080
243230005045	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
243230005046	Cation transport protein; Region: TrkH; cl17365
243230005047	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
243230005048	Cation transport protein; Region: TrkH; pfam02386
243230005049	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
243230005050	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243230005051	S-adenosylmethionine binding site [chemical binding]; other site
243230005052	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
243230005053	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
243230005054	active site
243230005055	HIGH motif; other site
243230005056	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
243230005057	active site
243230005058	nucleotide binding site [chemical binding]; other site
243230005059	HIGH motif; other site
243230005060	KMSKS motif; other site
243230005061	KMSKS motif; other site
243230005062	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
243230005063	tRNA binding surface [nucleotide binding]; other site
243230005064	anticodon binding site; other site
243230005065	Uncharacterized conserved protein [Function unknown]; Region: COG4121
243230005066	FAD dependent oxidoreductase; Region: DAO; pfam01266
243230005067	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
243230005068	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
243230005069	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
243230005070	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
243230005071	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243230005072	S-adenosylmethionine binding site [chemical binding]; other site
243230005073	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
243230005074	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243230005075	S-adenosylmethionine binding site [chemical binding]; other site
243230005076	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243230005077	S-adenosylmethionine binding site [chemical binding]; other site
243230005078	Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445
243230005079	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
243230005080	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
243230005081	Transcriptional regulator [Transcription]; Region: PaiB; COG2808
243230005082	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
243230005083	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
243230005084	active site
243230005085	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
243230005086	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
243230005087	P-loop; other site
243230005088	Magnesium ion binding site [ion binding]; other site
243230005089	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
243230005090	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
243230005091	active site
243230005092	nucleotide binding site [chemical binding]; other site
243230005093	HIGH motif; other site
243230005094	KMSKS motif; other site
243230005095	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
243230005096	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
243230005097	ligand binding site; other site
243230005098	oligomer interface; other site
243230005099	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
243230005100	dimer interface [polypeptide binding]; other site
243230005101	N-terminal domain interface [polypeptide binding]; other site
243230005102	sulfate 1 binding site; other site
243230005103	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
243230005104	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
243230005105	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
243230005106	putative dimer interface [polypeptide binding]; other site
243230005107	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710
243230005108	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
243230005109	acyl-activating enzyme (AAE) consensus motif; other site
243230005110	putative AMP binding site [chemical binding]; other site
243230005111	putative active site [active]
243230005112	putative CoA binding site [chemical binding]; other site
243230005113	tegument protein VP22; Provisional; Region: PHA03381
243230005114	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
243230005115	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
243230005116	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
243230005117	putative RNA binding site [nucleotide binding]; other site
243230005118	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243230005119	S-adenosylmethionine binding site [chemical binding]; other site
243230005120	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
243230005121	active site
243230005122	metal binding site [ion binding]; metal-binding site
243230005123	DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323
243230005124	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243230005125	ATP binding site [chemical binding]; other site
243230005126	Mg2+ binding site [ion binding]; other site
243230005127	G-X-G motif; other site
243230005128	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
243230005129	ATP binding site [chemical binding]; other site
243230005130	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
243230005131	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
243230005132	Dihydrouridine synthase (Dus); Region: Dus; pfam01207
243230005133	FMN binding site [chemical binding]; other site
243230005134	active site
243230005135	catalytic residues [active]
243230005136	substrate binding site [chemical binding]; other site
243230005137	Cysteine-rich D. radiodurans N terminus; Region: CDRN; pfam05174
243230005138	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
243230005139	short chain dehydrogenase; Provisional; Region: PRK07454
243230005140	putative NAD(P) binding site [chemical binding]; other site
243230005141	active site
243230005142	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
243230005143	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
243230005144	NAD binding site [chemical binding]; other site
243230005145	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
243230005146	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
243230005147	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
243230005148	active site
243230005149	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
243230005150	heterotetramer interface [polypeptide binding]; other site
243230005151	active site pocket [active]
243230005152	cleavage site
243230005153	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
243230005154	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243230005155	motif II; other site
243230005156	DNA polymerase I; Region: pola; TIGR00593
243230005157	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
243230005158	active site
243230005159	metal binding site 1 [ion binding]; metal-binding site
243230005160	putative 5' ssDNA interaction site; other site
243230005161	metal binding site 3; metal-binding site
243230005162	metal binding site 2 [ion binding]; metal-binding site
243230005163	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
243230005164	putative DNA binding site [nucleotide binding]; other site
243230005165	putative metal binding site [ion binding]; other site
243230005166	Taq polymerase, exonuclease; Region: Taq-exonuc; pfam09281
243230005167	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
243230005168	active site
243230005169	DNA binding site [nucleotide binding]
243230005170	catalytic site [active]
243230005171	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719
243230005172	manganese transport protein MntH; Reviewed; Region: PRK00701
243230005173	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
243230005174	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
243230005175	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
243230005176	metal binding site [ion binding]; metal-binding site
243230005177	dimer interface [polypeptide binding]; other site
243230005178	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
243230005179	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
243230005180	peptide binding site [polypeptide binding]; other site
243230005181	leucyl/phenylalanyl-tRNA--protein transferase; Region: aat; TIGR00667
243230005182	Uncharacterized conserved protein [Function unknown]; Region: COG3603
243230005183	ACT domain; Region: ACT_7; pfam13840
243230005184	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
243230005185	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
243230005186	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
243230005187	glutamate dehydrogenase; Provisional; Region: PRK09414
243230005188	Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812
243230005189	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
243230005190	NAD(P) binding site [chemical binding]; other site
243230005191	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
243230005192	aconitate hydratase; Validated; Region: PRK09277
243230005193	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
243230005194	substrate binding site [chemical binding]; other site
243230005195	ligand binding site [chemical binding]; other site
243230005196	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
243230005197	substrate binding site [chemical binding]; other site
243230005198	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
243230005199	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
243230005200	putative active site [active]
243230005201	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
243230005202	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
243230005203	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
243230005204	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
243230005205	structural tetrad; other site
243230005206	FOG: WD40 repeat [General function prediction only]; Region: COG2319
243230005207	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183
243230005208	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
243230005209	active site
243230005210	phosphoenolpyruvate synthase; Validated; Region: PRK06464
243230005211	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
243230005212	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
243230005213	PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
243230005214	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806
243230005215	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
243230005216	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
243230005217	Cysteine-rich domain; Region: CCG; pfam02754
243230005218	Cysteine-rich domain; Region: CCG; pfam02754
243230005219	FAD binding domain; Region: FAD_binding_4; pfam01565
243230005220	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
243230005221	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
243230005222	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
243230005223	Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462
243230005224	2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390
243230005225	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
243230005226	active site
243230005227	metal binding site [ion binding]; metal-binding site
243230005228	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
243230005229	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
243230005230	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
243230005231	Catalytic site [active]
243230005232	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
243230005233	Predicted transcriptional regulators [Transcription]; Region: COG1695
243230005234	Cysteine-rich D. radiodurans N terminus; Region: CDRN; pfam05174
243230005235	Protein of unknown function (DUF4127); Region: DUF4127; pfam13552
243230005236	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
243230005237	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
243230005238	active site
243230005239	dimer interface [polypeptide binding]; other site
243230005240	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
243230005241	dimer interface [polypeptide binding]; other site
243230005242	active site
243230005243	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243230005244	putative substrate translocation pore; other site
243230005245	Major Facilitator Superfamily; Region: MFS_1; pfam07690
243230005246	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
243230005247	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
243230005248	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
243230005249	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
243230005250	Walker A; other site
243230005251	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
243230005252	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
243230005253	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
243230005254	NlpC/P60 family; Region: NLPC_P60; pfam00877
243230005255	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
243230005256	Fe-S cluster binding site [ion binding]; other site
243230005257	active site
243230005258	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
243230005259	Cl- selectivity filter; other site
243230005260	Cl- binding residues [ion binding]; other site
243230005261	pore gating glutamate residue; other site
243230005262	dimer interface [polypeptide binding]; other site
243230005263	TrkA-C domain; Region: TrkA_C; pfam02080
243230005264	Septum formation inhibitor [Cell division and chromosome partitioning]; Region: MinC; COG0850
243230005265	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
243230005266	general stress protein 13; Validated; Region: PRK08059
243230005267	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
243230005268	RNA binding site [nucleotide binding]; other site
243230005269	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
243230005270	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
243230005271	protein binding site [polypeptide binding]; other site
243230005272	Nuclease-related domain; Region: NERD; pfam08378
243230005273	diaminopimelate decarboxylase; Region: lysA; TIGR01048
243230005274	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
243230005275	active site
243230005276	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
243230005277	substrate binding site [chemical binding]; other site
243230005278	catalytic residues [active]
243230005279	dimer interface [polypeptide binding]; other site
243230005280	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
243230005281	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
243230005282	Ligand Binding Site [chemical binding]; other site
243230005283	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
243230005284	FMN binding site [chemical binding]; other site
243230005285	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
243230005286	Helix-turn-helix domain; Region: HTH_28; pfam13518
243230005287	Winged helix-turn helix; Region: HTH_33; pfam13592
243230005288	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
243230005289	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
243230005290	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
243230005291	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
243230005292	putative metal binding site [ion binding]; other site
243230005293	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
243230005294	active site
243230005295	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
243230005296	Uncharacterized conserved protein [Function unknown]; Region: COG2128
243230005297	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
243230005298	Glutamine amidotransferase class-I; Region: GATase; pfam00117
243230005299	glutamine binding [chemical binding]; other site
243230005300	catalytic triad [active]
243230005301	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
243230005302	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
243230005303	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
243230005304	FOG: WD40-like repeat [Function unknown]; Region: COG1520
243230005305	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
243230005306	Trp docking motif [polypeptide binding]; other site
243230005307	active site
243230005308	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
243230005309	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
243230005310	chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777
243230005311	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
243230005312	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
243230005313	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; cl19891
243230005314	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
243230005315	Part of AAA domain; Region: AAA_19; pfam13245
243230005316	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
243230005317	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
243230005318	nudix motif; other site
243230005319	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
243230005320	substrate binding site [chemical binding]; other site
243230005321	ligand binding site [chemical binding]; other site
243230005322	Protein of unknown function (DUF2839); Region: DUF2839; pfam10999
243230005323	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
243230005324	substrate binding site [chemical binding]; other site
243230005325	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
243230005326	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
243230005327	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
243230005328	DNA-binding site [nucleotide binding]; DNA binding site
243230005329	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243230005330	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243230005331	homodimer interface [polypeptide binding]; other site
243230005332	catalytic residue [active]
243230005333	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
243230005334	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
243230005335	RNA binding surface [nucleotide binding]; other site
243230005336	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
243230005337	active site
243230005338	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
243230005339	Major royal jelly protein; Region: MRJP; pfam03022
243230005340	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
243230005341	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
243230005342	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
243230005343	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
243230005344	Predicted periplasmic protein [Function unknown]; Region: COG3656
243230005345	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
243230005346	hypothetical protein; Provisional; Region: PRK14645
243230005347	heptamer interface [polypeptide binding]; other site
243230005348	Sm1 motif; other site
243230005349	hexamer interface [polypeptide binding]; other site
243230005350	RNA binding site [nucleotide binding]; other site
243230005351	Sm2 motif; other site
243230005352	transcription termination factor NusA; Region: NusA; TIGR01953
243230005353	NusA N-terminal domain; Region: NusA_N; pfam08529
243230005354	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
243230005355	RNA binding site [nucleotide binding]; other site
243230005356	homodimer interface [polypeptide binding]; other site
243230005357	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
243230005358	G-X-X-G motif; other site
243230005359	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
243230005360	G-X-X-G motif; other site
243230005361	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
243230005362	putative RNA binding cleft [nucleotide binding]; other site
243230005363	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
243230005364	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
243230005365	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
243230005366	G1 box; other site
243230005367	putative GEF interaction site [polypeptide binding]; other site
243230005368	GTP/Mg2+ binding site [chemical binding]; other site
243230005369	Switch I region; other site
243230005370	G2 box; other site
243230005371	G3 box; other site
243230005372	Switch II region; other site
243230005373	G4 box; other site
243230005374	G5 box; other site
243230005375	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
243230005376	Translation-initiation factor 2; Region: IF-2; pfam11987
243230005377	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
243230005378	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
243230005379	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
243230005380	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
243230005381	Cupin domain; Region: Cupin_2; pfam07883
243230005382	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
243230005383	active site
243230005384	NTP binding site [chemical binding]; other site
243230005385	metal binding triad [ion binding]; metal-binding site
243230005386	antibiotic binding site [chemical binding]; other site
243230005387	Uncharacterized conserved protein [Function unknown]; Region: COG2361
243230005388	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318
243230005389	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243230005390	Zn2+ binding site [ion binding]; other site
243230005391	Mg2+ binding site [ion binding]; other site
243230005392	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
243230005393	glycine dehydrogenase; Provisional; Region: PRK05367
243230005394	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
243230005395	tetramer interface [polypeptide binding]; other site
243230005396	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243230005397	catalytic residue [active]
243230005398	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
243230005399	tetramer interface [polypeptide binding]; other site
243230005400	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243230005401	catalytic residue [active]
243230005402	VP2/VP3; Provisional; Region: PHA02616
243230005403	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
243230005404	lipoyl attachment site [posttranslational modification]; other site
243230005405	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
243230005406	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
243230005407	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
243230005408	Predicted membrane protein [Function unknown]; Region: COG4758
243230005409	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
243230005410	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
243230005411	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
243230005412	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
243230005413	UV damage repair endonuclease [DNA replication, recombination, and repair]; Region: Uve; COG4294
243230005414	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14954
243230005415	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
243230005416	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
243230005417	Protein export membrane protein; Region: SecD_SecF; pfam02355
243230005418	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
243230005419	ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448
243230005420	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
243230005421	ligand binding site; other site
243230005422	oligomer interface; other site
243230005423	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
243230005424	putative trimer interface [polypeptide binding]; other site
243230005425	putative CoA binding site [chemical binding]; other site
243230005426	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
243230005427	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
243230005428	putative catalytic cysteine [active]
243230005429	gamma-glutamyl kinase; Provisional; Region: PRK05429
243230005430	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
243230005431	nucleotide binding site [chemical binding]; other site
243230005432	homotetrameric interface [polypeptide binding]; other site
243230005433	putative phosphate binding site [ion binding]; other site
243230005434	putative allosteric binding site; other site
243230005435	PUA domain; Region: PUA; pfam01472
243230005436	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
243230005437	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243230005438	dimerization interface [polypeptide binding]; other site
243230005439	Protein of unknown function (DUF2847); Region: DUF2847; pfam11009
243230005440	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
243230005441	Methyltransferase domain; Region: Methyltransf_26; pfam13659
243230005442	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
243230005443	Mg++ binding site [ion binding]; other site
243230005444	putative catalytic motif [active]
243230005445	putative substrate binding site [chemical binding]; other site
243230005446	signal recognition particle protein; Region: ffh; TIGR00959
243230005447	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
243230005448	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
243230005449	P loop; other site
243230005450	GTP binding site [chemical binding]; other site
243230005451	Signal peptide binding domain; Region: SRP_SPB; pfam02978
243230005452	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
243230005453	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243230005454	Zn2+ binding site [ion binding]; other site
243230005455	Mg2+ binding site [ion binding]; other site
243230005456	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
243230005457	synthetase active site [active]
243230005458	NTP binding site [chemical binding]; other site
243230005459	metal binding site [ion binding]; metal-binding site
243230005460	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
243230005461	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
243230005462	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
243230005463	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
243230005464	Predicted membrane protein [Function unknown]; Region: COG2259
243230005465	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663
243230005466	SxDxEG motif; other site
243230005467	active site
243230005468	metal binding site [ion binding]; metal-binding site
243230005469	homopentamer interface [polypeptide binding]; other site
243230005470	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230005471	Coenzyme A binding pocket [chemical binding]; other site
243230005472	Transcriptional regulator PadR-like family; Region: PadR; cl17335
243230005473	glycogen branching enzyme; Provisional; Region: PRK14706
243230005474	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
243230005475	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
243230005476	active site
243230005477	catalytic site [active]
243230005478	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
243230005479	methionine sulfoxide reductase A; Provisional; Region: PRK14054
243230005480	Protein kinase domain; Region: Pkinase; pfam00069
243230005481	Catalytic domain of Protein Kinases; Region: PKc; cd00180
243230005482	active site
243230005483	ATP binding site [chemical binding]; other site
243230005484	substrate binding site [chemical binding]; other site
243230005485	activation loop (A-loop); other site
243230005486	Cytosol aminopeptidase family, N-terminal domain; Region: Peptidase_M17_N; pfam02789
243230005487	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
243230005488	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
243230005489	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
243230005490	Competence protein; Region: Competence; pfam03772
243230005491	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
243230005492	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
243230005493	comEA protein; Region: comE; TIGR01259
243230005494	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
243230005495	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
243230005496	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
243230005497	hypothetical protein; Provisional; Region: PRK10621
243230005498	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
243230005499	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
243230005500	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
243230005501	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
243230005502	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
243230005503	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
243230005504	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
243230005505	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
243230005506	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
243230005507	MraZ protein; Region: MraZ; pfam02381
243230005508	MraZ protein; Region: MraZ; pfam02381
243230005509	MraW methylase family; Region: Methyltransf_5; cl17771
243230005510	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243230005511	S-adenosylmethionine binding site [chemical binding]; other site
243230005512	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
243230005513	Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
243230005514	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
243230005515	Ferredoxin [Energy production and conversion]; Region: COG1146
243230005516	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
243230005517	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
243230005518	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
243230005519	Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391
243230005520	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
243230005521	Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and residues that can...; Region: MLE_like; cd03315
243230005522	Enolase, N-terminal domain; Region: Enolase_N; pfam03952
243230005523	active site
243230005524	PEGA domain; Region: PEGA; pfam08308
243230005525	GMP synthase; Reviewed; Region: guaA; PRK00074
243230005526	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
243230005527	AMP/PPi binding site [chemical binding]; other site
243230005528	candidate oxyanion hole; other site
243230005529	catalytic triad [active]
243230005530	potential glutamine specificity residues [chemical binding]; other site
243230005531	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
243230005532	ATP Binding subdomain [chemical binding]; other site
243230005533	Ligand Binding sites [chemical binding]; other site
243230005534	Dimerization subdomain; other site
243230005535	Predicted membrane protein [Function unknown]; Region: COG2364
243230005536	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
243230005537	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
243230005538	Predicted endonuclease distantly related to archaeal Holliday junction resolvase and Mrr-like restriction enzymes [Defense mechanisms]; Region: COG1787
243230005539	Restriction endonuclease; Region: Mrr_cat; pfam04471
243230005540	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
243230005541	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
243230005542	active site
243230005543	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
243230005544	Predicted membrane protein [Function unknown]; Region: COG2862
243230005545	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
243230005546	RNHCP domain; Region: RNHCP; pfam12647
243230005547	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
243230005548	MOSC domain; Region: MOSC; pfam03473
243230005549	3-alpha domain; Region: 3-alpha; pfam03475
243230005550	Transcriptional regulators [Transcription]; Region: PurR; COG1609
243230005551	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
243230005552	DNA binding site [nucleotide binding]
243230005553	domain linker motif; other site
243230005554	Ligand-binding domain of uncharacterized transcription regulators from Thermus thermophilus and close homologs; Region: PBP1_LacI_like_12; cd06297
243230005555	putative dimerization interface [polypeptide binding]; other site
243230005556	putative ligand binding site [chemical binding]; other site
243230005557	Copper(I)-binding protein [Inorganic ion transport and    metabolism]; Region: COG2847
243230005558	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
243230005559	Cu(I) binding site [ion binding]; other site
243230005560	Predicted membrane protein [Function unknown]; Region: COG3336
243230005561	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
243230005562	Uncharacterized metal-binding protein [General function prediction only]; Region: COG2389
243230005563	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
243230005564	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
243230005565	active site
243230005566	catalytic tetrad [active]
243230005567	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243230005568	TPR motif; other site
243230005569	Tetratricopeptide repeat; Region: TPR_16; pfam13432
243230005570	binding surface
243230005571	TPR repeat; Region: TPR_11; pfam13414
243230005572	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243230005573	binding surface
243230005574	TPR motif; other site
243230005575	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243230005576	TPR motif; other site
243230005577	TPR repeat; Region: TPR_11; pfam13414
243230005578	binding surface
243230005579	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
243230005580	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
243230005581	CoA-binding site [chemical binding]; other site
243230005582	ATP-binding [chemical binding]; other site
243230005583	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
243230005584	active site
243230005585	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
243230005586	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
243230005587	putative DNA binding site [nucleotide binding]; other site
243230005588	putative Zn2+ binding site [ion binding]; other site
243230005589	AsnC family; Region: AsnC_trans_reg; pfam01037
243230005590	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
243230005591	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
243230005592	hexamer interface [polypeptide binding]; other site
243230005593	ligand binding site [chemical binding]; other site
243230005594	putative active site [active]
243230005595	NAD(P) binding site [chemical binding]; other site
243230005596	recombination factor protein RarA; Reviewed; Region: PRK13342
243230005597	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243230005598	Walker A motif; other site
243230005599	ATP binding site [chemical binding]; other site
243230005600	Walker B motif; other site
243230005601	arginine finger; other site
243230005602	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
243230005603	Protein of unknown function (DUF1572); Region: DUF1572; pfam07609
243230005604	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243230005605	active site
243230005606	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
243230005607	Helix-hairpin-helix containing domain; Region: HHH_4; pfam14490
243230005608	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243230005609	Walker A motif; other site
243230005610	ATP binding site [chemical binding]; other site
243230005611	Walker B motif; other site
243230005612	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
243230005613	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
243230005614	Transcriptional regulators [Transcription]; Region: FadR; COG2186
243230005615	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
243230005616	DNA-binding site [nucleotide binding]; DNA binding site
243230005617	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
243230005618	L-lactate permease; Region: Lactate_perm; cl00701
243230005619	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
243230005620	Cysteine-rich domain; Region: CCG; pfam02754
243230005621	Cysteine-rich domain; Region: CCG; pfam02754
243230005622	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
243230005623	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
243230005624	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
243230005625	Uncharacterized conserved protein [Function unknown]; Region: COG1556
243230005626	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
243230005627	AAA domain; Region: AAA_33; pfam13671
243230005628	ATP-binding site [chemical binding]; other site
243230005629	Gluconate-6-phosphate binding site [chemical binding]; other site
243230005630	Ion channel; Region: Ion_trans_2; pfam07885
243230005631	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
243230005632	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
243230005633	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
243230005634	DNA gyrase subunit A; Validated; Region: PRK05560
243230005635	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
243230005636	CAP-like domain; other site
243230005637	active site
243230005638	primary dimer interface [polypeptide binding]; other site
243230005639	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
243230005640	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
243230005641	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
243230005642	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
243230005643	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
243230005644	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
243230005645	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
243230005646	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
243230005647	RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200
243230005648	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
243230005649	generic binding surface II; other site
243230005650	ssDNA binding site; other site
243230005651	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
243230005652	ATP binding site [chemical binding]; other site
243230005653	putative Mg++ binding site [ion binding]; other site
243230005654	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243230005655	nucleotide binding region [chemical binding]; other site
243230005656	ATP-binding site [chemical binding]; other site
243230005657	Protein of unknown function (DUF2572); Region: DUF2572; pfam10833
243230005658	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
243230005659	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230005660	Coenzyme A binding pocket [chemical binding]; other site
243230005661	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
243230005662	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230005663	Coenzyme A binding pocket [chemical binding]; other site
243230005664	hypothetical protein; Provisional; Region: PRK06762
243230005665	AAA domain; Region: AAA_33; pfam13671
243230005666	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
243230005667	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
243230005668	active site
243230005669	metal binding site [ion binding]; metal-binding site
243230005670	DNA binding site [nucleotide binding]
243230005671	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
243230005672	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
243230005673	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
243230005674	Walker A/P-loop; other site
243230005675	ATP binding site [chemical binding]; other site
243230005676	Q-loop/lid; other site
243230005677	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
243230005678	ABC transporter signature motif; other site
243230005679	Walker B; other site
243230005680	D-loop; other site
243230005681	H-loop/switch region; other site
243230005682	Uncharacterized conserved protein [Function unknown]; Region: COG5316
243230005683	Uncharacterized conserved protein [Function unknown]; Region: COG5316
243230005684	Predicted membrane protein [Function unknown]; Region: COG4270
243230005685	Transposase IS200 like; Region: Y1_Tnp; pfam01797
243230005686	glycerol kinase; Provisional; Region: glpK; PRK00047
243230005687	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
243230005688	N- and C-terminal domain interface [polypeptide binding]; other site
243230005689	active site
243230005690	MgATP binding site [chemical binding]; other site
243230005691	catalytic site [active]
243230005692	metal binding site [ion binding]; metal-binding site
243230005693	glycerol binding site [chemical binding]; other site
243230005694	homotetramer interface [polypeptide binding]; other site
243230005695	homodimer interface [polypeptide binding]; other site
243230005696	FBP binding site [chemical binding]; other site
243230005697	protein IIAGlc interface [polypeptide binding]; other site
243230005698	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
243230005699	amphipathic channel; other site
243230005700	Asn-Pro-Ala signature motifs; other site
243230005701	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
243230005702	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
243230005703	Transposase IS200 like; Region: Y1_Tnp; pfam01797
243230005704	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
243230005705	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
243230005706	Probable transposase; Region: OrfB_IS605; pfam01385
243230005707	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
243230005708	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
243230005709	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
243230005710	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
243230005711	DNA binding residues [nucleotide binding]
243230005712	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
243230005713	adhesin; Provisional; Region: PRK09752
243230005714	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
243230005715	Subtilase family; Region: Peptidase_S8; pfam00082
243230005716	active site
243230005717	catalytic triad [active]
243230005718	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
243230005719	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243230005720	NAD(P) binding site [chemical binding]; other site
243230005721	active site
243230005722	Polyphosphate kinase C-terminal domain; Region: PP_kinase_C; pfam13090
243230005723	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
243230005724	putative domain interface [polypeptide binding]; other site
243230005725	putative active site [active]
243230005726	catalytic site [active]
243230005727	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
243230005728	putative domain interface [polypeptide binding]; other site
243230005729	putative active site [active]
243230005730	catalytic site [active]
243230005731	META domain; Region: META; pfam03724
243230005732	Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187
243230005733	META domain; Region: META; pfam03724
243230005734	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
243230005735	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
243230005736	dimer interface [polypeptide binding]; other site
243230005737	active site
243230005738	acyl carrier protein; Provisional; Region: acpP; PRK00982
243230005739	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
243230005740	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
243230005741	NAD(P) binding site [chemical binding]; other site
243230005742	homotetramer interface [polypeptide binding]; other site
243230005743	homodimer interface [polypeptide binding]; other site
243230005744	active site
243230005745	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
243230005746	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
243230005747	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879
243230005748	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
243230005749	dimer interface [polypeptide binding]; other site
243230005750	active site
243230005751	CoA binding pocket [chemical binding]; other site
243230005752	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
243230005753	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
243230005754	dimer interface [polypeptide binding]; other site
243230005755	active site
243230005756	CoA binding pocket [chemical binding]; other site
243230005757	FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]; Region: Tig; COG0544
243230005758	Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697
243230005759	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
243230005760	Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
243230005761	RNA/DNA hybrid binding site [nucleotide binding]; other site
243230005762	active site
243230005763	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
243230005764	[2Fe-2S] cluster binding site [ion binding]; other site
243230005765	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
243230005766	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
243230005767	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
243230005768	peptide binding site [polypeptide binding]; other site
243230005769	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
243230005770	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575
243230005771	putative acyltransferase; Provisional; Region: PRK05790
243230005772	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
243230005773	dimer interface [polypeptide binding]; other site
243230005774	active site
243230005775	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
243230005776	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
243230005777	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
243230005778	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
243230005779	Walker A motif; other site
243230005780	ATP binding site [chemical binding]; other site
243230005781	Walker B motif; other site
243230005782	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
243230005783	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
243230005784	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
243230005785	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
243230005786	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
243230005787	Walker A motif; other site
243230005788	ATP binding site [chemical binding]; other site
243230005789	Walker B motif; other site
243230005790	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243230005791	active site
243230005792	motif I; other site
243230005793	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
243230005794	motif II; other site
243230005795	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
243230005796	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
243230005797	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
243230005798	NAD binding site [chemical binding]; other site
243230005799	homotetramer interface [polypeptide binding]; other site
243230005800	homodimer interface [polypeptide binding]; other site
243230005801	substrate binding site [chemical binding]; other site
243230005802	active site
243230005803	NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370
243230005804	dimer interface [polypeptide binding]; other site
243230005805	FMN binding site [chemical binding]; other site
243230005806	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
243230005807	putative DNA binding site [nucleotide binding]; other site
243230005808	dimerization interface [polypeptide binding]; other site
243230005809	putative Zn2+ binding site [ion binding]; other site
243230005810	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
243230005811	Uncharacterized conserved protein, YhbC family [Function unknown]; Region: COG0782
243230005812	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
243230005813	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
243230005814	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
243230005815	oligomer interface [polypeptide binding]; other site
243230005816	active site residues [active]
243230005817	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
243230005818	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
243230005819	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243230005820	Walker A motif; other site
243230005821	ATP binding site [chemical binding]; other site
243230005822	Walker B motif; other site
243230005823	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
243230005824	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
243230005825	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
243230005826	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243230005827	Walker A motif; other site
243230005828	ATP binding site [chemical binding]; other site
243230005829	Walker B motif; other site
243230005830	arginine finger; other site
243230005831	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
243230005832	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
243230005833	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230005834	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
243230005835	Coenzyme A binding pocket [chemical binding]; other site
243230005836	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193
243230005837	MutS domain III; Region: MutS_III; pfam05192
243230005838	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
243230005839	Walker A/P-loop; other site
243230005840	ATP binding site [chemical binding]; other site
243230005841	Q-loop/lid; other site
243230005842	ABC transporter signature motif; other site
243230005843	Walker B; other site
243230005844	D-loop; other site
243230005845	H-loop/switch region; other site
243230005846	Smr domain; Region: Smr; pfam01713
243230005847	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230005848	Coenzyme A binding pocket [chemical binding]; other site
243230005849	putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208
243230005850	oligomer interface [polypeptide binding]; other site
243230005851	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
243230005852	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
243230005853	putative NAD(P) binding site [chemical binding]; other site
243230005854	active site
243230005855	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
243230005856	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
243230005857	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
243230005858	Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539
243230005859	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
243230005860	RNA binding site [nucleotide binding]; other site
243230005861	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
243230005862	RNA binding site [nucleotide binding]; other site
243230005863	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
243230005864	RNA binding site [nucleotide binding]; other site
243230005865	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
243230005866	RNA binding site [nucleotide binding]; other site
243230005867	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
243230005868	RNA binding site [nucleotide binding]; other site
243230005869	Thymidine kinase [Nucleotide transport and metabolism]; Region: Tdk; COG1435
243230005870	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
243230005871	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
243230005872	EDD domain protein, DegV family; Region: DegV; TIGR00762
243230005873	oxygen-independent coproporphyrinogen III oxidase; Region: hemN; TIGR00538
243230005874	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
243230005875	KH domain; Region: KH_1; pfam00013
243230005876	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
243230005877	ATP binding site [chemical binding]; other site
243230005878	putative Mg++ binding site [ion binding]; other site
243230005879	Protein of unknown function (DUF3293); Region: DUF3293; pfam11697
243230005880	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
243230005881	Permutation of conserved domain; other site
243230005882	active site
243230005883	Rhomboid family; Region: Rhomboid; pfam01694
243230005884	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
243230005885	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
243230005886	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
243230005887	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
243230005888	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
243230005889	Mechanosensitive ion channel; Region: MS_channel; pfam00924
243230005890	putative phosphate acyltransferase; Provisional; Region: PRK05331
243230005891	Uncharacterized conserved protein [Function unknown]; Region: COG1432
243230005892	LabA_like proteins; Region: LabA; cd10911
243230005893	putative metal binding site [ion binding]; other site
243230005894	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
243230005895	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
243230005896	tetramer interface [polypeptide binding]; other site
243230005897	heme binding pocket [chemical binding]; other site
243230005898	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
243230005899	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
243230005900	putative dimer interface [polypeptide binding]; other site
243230005901	catalytic triad [active]
243230005902	DinB superfamily; Region: DinB_2; pfam12867
243230005903	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
243230005904	23S rRNA binding site [nucleotide binding]; other site
243230005905	L21 binding site [polypeptide binding]; other site
243230005906	L13 binding site [polypeptide binding]; other site
243230005907	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
243230005908	Protein of unknown function (DUF3809); Region: DUF3809; pfam12723
243230005909	Protein of unknown function (DUF3248); Region: DUF3248; pfam11609
243230005910	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
243230005911	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
243230005912	Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774
243230005913	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
243230005914	G-X-X-G motif; other site
243230005915	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13829
243230005916	RimM N-terminal domain; Region: RimM; pfam01782
243230005917	PRC-barrel domain; Region: PRC; pfam05239
243230005918	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
243230005919	Acyltransferase family; Region: Acyl_transf_3; pfam01757
243230005920	fructose 1,6-bisphosphatase II; Reviewed; Region: glpX; PRK09479
243230005921	active site
243230005922	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
243230005923	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
243230005924	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
243230005925	hypothetical protein; Provisional; Region: PRK06446
243230005926	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681
243230005927	metal binding site [ion binding]; metal-binding site
243230005928	dimer interface [polypeptide binding]; other site
243230005929	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
243230005930	Thioredoxin; Region: Thioredoxin_4; cl17273
243230005931	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
243230005932	catalytic residues [active]
243230005933	membrane protein; Provisional; Region: PRK14402
243230005934	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
243230005935	dimer interface [polypeptide binding]; other site
243230005936	substrate binding site [chemical binding]; other site
243230005937	metal binding site [ion binding]; metal-binding site
243230005938	Predicted integral membrane protein [Function unknown]; Region: COG5652
243230005939	Predicted membrane protein [Function unknown]; Region: COG4270
243230005940	hypothetical protein; Provisional; Region: PRK08201
243230005941	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
243230005942	metal binding site [ion binding]; metal-binding site
243230005943	putative dimer interface [polypeptide binding]; other site
243230005944	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
243230005945	active site
243230005946	substrate binding site [chemical binding]; other site
243230005947	cosubstrate binding site; other site
243230005948	catalytic site [active]
243230005949	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
243230005950	Helix-turn-helix domain; Region: HTH_28; pfam13518
243230005951	Winged helix-turn helix; Region: HTH_33; pfam13592
243230005952	Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306
243230005953	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
243230005954	CoenzymeA binding site [chemical binding]; other site
243230005955	subunit interaction site [polypeptide binding]; other site
243230005956	PHB binding site; other site
243230005957	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
243230005958	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
243230005959	B12 binding site [chemical binding]; other site
243230005960	cobalt ligand [ion binding]; other site
243230005961	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
243230005962	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
243230005963	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
243230005964	Aminoglycoside N3'-acetyltransferase [Defense mechanisms]; Region: COG2746
243230005965	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762
243230005966	trehalose synthase; Region: treS_nterm; TIGR02456
243230005967	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
243230005968	active site
243230005969	catalytic site [active]
243230005970	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
243230005971	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
243230005972	P-loop; other site
243230005973	Magnesium ion binding site [ion binding]; other site
243230005974	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
243230005975	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
243230005976	Uncharacterized conserved protein [Function unknown]; Region: COG2308
243230005977	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
243230005978	peripheral dimer interface [polypeptide binding]; other site
243230005979	core dimer interface [polypeptide binding]; other site
243230005980	L10 interface [polypeptide binding]; other site
243230005981	L11 interface [polypeptide binding]; other site
243230005982	putative EF-Tu interaction site [polypeptide binding]; other site
243230005983	putative EF-G interaction site [polypeptide binding]; other site
243230005984	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
243230005985	23S rRNA interface [nucleotide binding]; other site
243230005986	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
243230005987	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
243230005988	mRNA/rRNA interface [nucleotide binding]; other site
243230005989	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
243230005990	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
243230005991	23S rRNA interface [nucleotide binding]; other site
243230005992	L7/L12 interface [polypeptide binding]; other site
243230005993	putative thiostrepton binding site; other site
243230005994	L25 interface [polypeptide binding]; other site
243230005995	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
243230005996	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
243230005997	putative homodimer interface [polypeptide binding]; other site
243230005998	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
243230005999	heterodimer interface [polypeptide binding]; other site
243230006000	homodimer interface [polypeptide binding]; other site
243230006001	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
243230006002	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
243230006003	elongation factor Tu; Reviewed; Region: PRK00049
243230006004	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
243230006005	G1 box; other site
243230006006	GEF interaction site [polypeptide binding]; other site
243230006007	GTP/Mg2+ binding site [chemical binding]; other site
243230006008	Switch I region; other site
243230006009	G2 box; other site
243230006010	G3 box; other site
243230006011	Switch II region; other site
243230006012	G4 box; other site
243230006013	G5 box; other site
243230006014	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
243230006015	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
243230006016	Antibiotic Binding Site [chemical binding]; other site
243230006017	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
243230006018	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
243230006019	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243230006020	Walker A/P-loop; other site
243230006021	ATP binding site [chemical binding]; other site
243230006022	Q-loop/lid; other site
243230006023	ABC transporter signature motif; other site
243230006024	Walker B; other site
243230006025	D-loop; other site
243230006026	H-loop/switch region; other site
243230006027	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
243230006028	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
243230006029	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
243230006030	Walker A/P-loop; other site
243230006031	ATP binding site [chemical binding]; other site
243230006032	Q-loop/lid; other site
243230006033	ABC transporter signature motif; other site
243230006034	Walker B; other site
243230006035	D-loop; other site
243230006036	H-loop/switch region; other site
243230006037	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
243230006038	PhoU domain; Region: PhoU; pfam01895
243230006039	PhoU domain; Region: PhoU; pfam01895
243230006040	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
243230006041	Zn binding site [ion binding]; other site
243230006042	Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187
243230006043	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
243230006044	glycyl-tRNA synthetase; Provisional; Region: PRK04173
243230006045	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
243230006046	dimer interface [polypeptide binding]; other site
243230006047	motif 1; other site
243230006048	active site
243230006049	motif 2; other site
243230006050	motif 3; other site
243230006051	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
243230006052	anticodon binding site; other site
243230006053	FOG: WD40 repeat [General function prediction only]; Region: COG2319
243230006054	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
243230006055	structural tetrad; other site
243230006056	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
243230006057	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
243230006058	RNase E interface [polypeptide binding]; other site
243230006059	trimer interface [polypeptide binding]; other site
243230006060	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
243230006061	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
243230006062	RNase E interface [polypeptide binding]; other site
243230006063	trimer interface [polypeptide binding]; other site
243230006064	active site
243230006065	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
243230006066	putative nucleic acid binding region [nucleotide binding]; other site
243230006067	G-X-X-G motif; other site
243230006068	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
243230006069	RNA binding site [nucleotide binding]; other site
243230006070	domain interface; other site
243230006071	Rubella capsid protein; Region: Rubella_Capsid; pfam05750
243230006072	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
243230006073	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
243230006074	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
243230006075	Divergent PAP2 family; Region: DUF212; pfam02681
243230006076	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
243230006077	putative RNA binding site [nucleotide binding]; other site
243230006078	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
243230006079	NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272
243230006080	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
243230006081	nucleotide binding pocket [chemical binding]; other site
243230006082	K-X-D-G motif; other site
243230006083	catalytic site [active]
243230006084	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
243230006085	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
243230006086	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
243230006087	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
243230006088	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
243230006089	Dimer interface [polypeptide binding]; other site
243230006090	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
243230006091	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
243230006092	ligand binding site [chemical binding]; other site
243230006093	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14323
243230006094	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
243230006095	active site
243230006096	substrate binding site [chemical binding]; other site
243230006097	metal binding site [ion binding]; metal-binding site
243230006098	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
243230006099	AAA domain; Region: AAA_33; pfam13671
243230006100	AAA domain; Region: AAA_18; pfam13238
243230006101	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
243230006102	active site
243230006103	DNA binding site [nucleotide binding]
243230006104	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
243230006105	catalytic loop [active]
243230006106	iron binding site [ion binding]; other site
243230006107	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
243230006108	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
243230006109	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
243230006110	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
243230006111	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
243230006112	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
243230006113	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
243230006114	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
243230006115	active site
243230006116	dimer interface [polypeptide binding]; other site
243230006117	motif 1; other site
243230006118	motif 2; other site
243230006119	motif 3; other site
243230006120	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
243230006121	anticodon binding site; other site
243230006122	Bacterial PH domain; Region: bPH_4; cl19751
243230006123	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
243230006124	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
243230006125	putative active site [active]
243230006126	catalytic site [active]
243230006127	putative metal binding site [ion binding]; other site
243230006128	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
243230006129	catalytic residues [active]
243230006130	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
243230006131	Translation initiation factor 3 (IF-3) [Translation, ribosomal structure and biogenesis]; Region: InfC; COG0290
243230006132	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
243230006133	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
243230006134	Predicted membrane protein [Function unknown]; Region: COG4269
243230006135	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
243230006136	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
243230006137	trimer interface [polypeptide binding]; other site
243230006138	putative metal binding site [ion binding]; other site
243230006139	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK06995
243230006140	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
243230006141	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
243230006142	malonyl-CoA binding site [chemical binding]; other site
243230006143	dimer interface [polypeptide binding]; other site
243230006144	active site
243230006145	product binding site; other site
243230006146	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319
243230006147	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
243230006148	trimer interface [polypeptide binding]; other site
243230006149	putative active site [active]
243230006150	Zn binding site [ion binding]; other site
243230006151	Predicted transcriptional regulator [Transcription]; Region: COG1959
243230006152	Rrf2 family protein; Region: rrf2_super; TIGR00738
243230006153	Cytochrome c; Region: Cytochrom_C; pfam00034
243230006154	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
243230006155	tandem repeat interface [polypeptide binding]; other site
243230006156	oligomer interface [polypeptide binding]; other site
243230006157	active site residues [active]
243230006158	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
243230006159	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
243230006160	tandem repeat interface [polypeptide binding]; other site
243230006161	oligomer interface [polypeptide binding]; other site
243230006162	active site residues [active]
243230006163	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243230006164	Major Facilitator Superfamily; Region: MFS_1; pfam07690
243230006165	putative substrate translocation pore; other site
243230006166	Uncharacterized conserved protein [Function unknown]; Region: COG1359
243230006167	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
243230006168	FeS assembly protein SufD; Region: sufD; TIGR01981
243230006169	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
243230006170	oligomeric interface; other site
243230006171	putative active site [active]
243230006172	homodimer interface [polypeptide binding]; other site
243230006173	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
243230006174	active site
243230006175	metal binding site [ion binding]; metal-binding site
243230006176	FeS assembly protein SufB; Region: sufB; TIGR01980
243230006177	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
243230006178	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
243230006179	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
243230006180	Walker A/P-loop; other site
243230006181	ATP binding site [chemical binding]; other site
243230006182	Q-loop/lid; other site
243230006183	ABC transporter signature motif; other site
243230006184	Walker B; other site
243230006185	D-loop; other site
243230006186	H-loop/switch region; other site
243230006187	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
243230006188	FOG: WD40-like repeat [Function unknown]; Region: COG1520
243230006189	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
243230006190	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
243230006191	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
243230006192	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
243230006193	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
243230006194	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
243230006195	5S rRNA interface [nucleotide binding]; other site
243230006196	23S rRNA interface [nucleotide binding]; other site
243230006197	L5 interface [polypeptide binding]; other site
243230006198	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
243230006199	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
243230006200	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
243230006201	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
243230006202	23S rRNA binding site [nucleotide binding]; other site
243230006203	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
243230006204	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
243230006205	SecY translocase; Region: SecY; pfam00344
243230006206	adenylate kinase; Provisional; Region: PRK14527
243230006207	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
243230006208	AMP-binding site [chemical binding]; other site
243230006209	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
243230006210	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
243230006211	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
243230006212	Walker A/P-loop; other site
243230006213	ATP binding site [chemical binding]; other site
243230006214	Q-loop/lid; other site
243230006215	ABC transporter signature motif; other site
243230006216	Walker B; other site
243230006217	D-loop; other site
243230006218	H-loop/switch region; other site
243230006219	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
243230006220	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
243230006221	Walker A/P-loop; other site
243230006222	ATP binding site [chemical binding]; other site
243230006223	Q-loop/lid; other site
243230006224	ABC transporter signature motif; other site
243230006225	Walker B; other site
243230006226	D-loop; other site
243230006227	H-loop/switch region; other site
243230006228	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
243230006229	TM-ABC transporter signature motif; other site
243230006230	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
243230006231	TM-ABC transporter signature motif; other site
243230006232	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_13; cd06348
243230006233	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
243230006234	putative ligand binding site [chemical binding]; other site
243230006235	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
243230006236	rRNA binding site [nucleotide binding]; other site
243230006237	predicted 30S ribosome binding site; other site
243230006238	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
243230006239	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
243230006240	30S ribosomal protein S11; Validated; Region: PRK05309
243230006241	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
243230006242	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
243230006243	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
243230006244	RNA binding surface [nucleotide binding]; other site
243230006245	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
243230006246	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
243230006247	alphaNTD - beta interaction site [polypeptide binding]; other site
243230006248	alphaNTD homodimer interface [polypeptide binding]; other site
243230006249	alphaNTD - beta' interaction site [polypeptide binding]; other site
243230006250	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
243230006251	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
243230006252	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
243230006253	Collagenase; Region: DUF3656; pfam12392
243230006254	Quinolinate phosphoribosyl transferase, C-terminal domain; Region: QRPTase_C; cl19145
243230006255	Peptidase family U32; Region: Peptidase_U32; cl03113
243230006256	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
243230006257	Ligand Binding Site [chemical binding]; other site
243230006258	Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372
243230006259	Protein of unknown function (DUF3084); Region: DUF3084; pfam11283
243230006260	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
243230006261	F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192
243230006262	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
243230006263	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
243230006264	Walker A/P-loop; other site
243230006265	ATP binding site [chemical binding]; other site
243230006266	Q-loop/lid; other site
243230006267	ABC transporter signature motif; other site
243230006268	Walker B; other site
243230006269	D-loop; other site
243230006270	H-loop/switch region; other site
243230006271	phosphopentomutase; Provisional; Region: PRK05362
243230006272	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
243230006273	Predicted kinase [General function prediction only]; Region: COG0645
243230006274	AAA domain; Region: AAA_33; pfam13671
243230006275	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
243230006276	histidinol dehydrogenase; Region: hisD; TIGR00069
243230006277	NAD binding site [chemical binding]; other site
243230006278	dimerization interface [polypeptide binding]; other site
243230006279	product binding site; other site
243230006280	substrate binding site [chemical binding]; other site
243230006281	zinc binding site [ion binding]; other site
243230006282	catalytic residues [active]
243230006283	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
243230006284	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
243230006285	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
243230006286	Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829
243230006287	Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406
243230006288	ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119
243230006289	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243230006290	Walker A/P-loop; other site
243230006291	ATP binding site [chemical binding]; other site
243230006292	Q-loop/lid; other site
243230006293	ABC transporter signature motif; other site
243230006294	Walker B; other site
243230006295	D-loop; other site
243230006296	H-loop/switch region; other site
243230006297	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
243230006298	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243230006299	active site
243230006300	motif I; other site
243230006301	motif II; other site
243230006302	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243230006303	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
243230006304	YidC periplasmic domain; Region: YidC_periplas; pfam14849
243230006305	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
243230006306	hypothetical protein; Provisional; Region: PRK14383
243230006307	Ribonuclease P; Region: Ribonuclease_P; cl00457
243230006308	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
243230006309	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
243230006310	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
243230006311	Walker A/P-loop; other site
243230006312	ATP binding site [chemical binding]; other site
243230006313	Q-loop/lid; other site
243230006314	ABC transporter signature motif; other site
243230006315	Walker B; other site
243230006316	D-loop; other site
243230006317	H-loop/switch region; other site
243230006318	TOBE domain; Region: TOBE; pfam03459
243230006319	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243230006320	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243230006321	substrate binding pocket [chemical binding]; other site
243230006322	membrane-bound complex binding site; other site
243230006323	hinge residues; other site
243230006324	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
243230006325	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243230006326	dimer interface [polypeptide binding]; other site
243230006327	conserved gate region; other site
243230006328	putative PBP binding loops; other site
243230006329	ABC-ATPase subunit interface; other site
243230006330	Protein of unknown function (DUF3208); Region: DUF3208; pfam11482
243230006331	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
243230006332	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
243230006333	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
243230006334	dimer interface [polypeptide binding]; other site
243230006335	active site
243230006336	Schiff base residues; other site
243230006337	Cyclin-dependent kinase inhibitor 3 (CDKN3); Region: CDKN3; pfam05706
243230006338	Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453
243230006339	Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or...; Region: DSPc; cl00053
243230006340	active site
243230006341	catalytic residues [active]
243230006342	Deoxyinosine 3'endonuclease (endonuclease V) [DNA replication, recombination, and repair]; Region: Nfi; COG1515
243230006343	Active_site [active]
243230006344	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944
243230006345	Fe-S cluster binding site [ion binding]; other site
243230006346	substrate binding site [chemical binding]; other site
243230006347	catalytic site [active]
243230006348	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
243230006349	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
243230006350	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
243230006351	putative RNA binding site [nucleotide binding]; other site
243230006352	16S rRNA methyltransferase B; Provisional; Region: PRK14902
243230006353	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243230006354	S-adenosylmethionine binding site [chemical binding]; other site
243230006355	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243230006356	Major Facilitator Superfamily; Region: MFS_1; pfam07690
243230006357	putative substrate translocation pore; other site
243230006358	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
243230006359	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878
243230006360	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
243230006361	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
243230006362	active site
243230006363	HIGH motif; other site
243230006364	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
243230006365	KMSKS motif; other site
243230006366	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
243230006367	tRNA binding surface [nucleotide binding]; other site
243230006368	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
243230006369	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
243230006370	Domain of unknown function DUF21; Region: DUF21; pfam01595
243230006371	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
243230006372	Transporter associated domain; Region: CorC_HlyC; smart01091
243230006373	cytidine deaminase, homotetrameric; Region: cyt_deam_tetra; TIGR01354
243230006374	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
243230006375	active site
243230006376	catalytic motif [active]
243230006377	Zn binding site [ion binding]; other site
243230006378	adenylosuccinate lyase; Provisional; Region: PRK07492
243230006379	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
243230006380	tetramer interface [polypeptide binding]; other site
243230006381	active site
243230006382	V4R domain; Region: V4R; cl15268
243230006383	Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018
243230006384	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
243230006385	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
243230006386	G1 box; other site
243230006387	GTP/Mg2+ binding site [chemical binding]; other site
243230006388	G2 box; other site
243230006389	Switch I region; other site
243230006390	G3 box; other site
243230006391	Switch II region; other site
243230006392	G4 box; other site
243230006393	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
243230006394	active site
243230006395	catalytic triad [active]
243230006396	dimer interface [polypeptide binding]; other site
243230006397	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
243230006398	homodimer interface [polypeptide binding]; other site
243230006399	substrate-cofactor binding pocket; other site
243230006400	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243230006401	catalytic residue [active]
243230006402	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
243230006403	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243230006404	S-adenosylmethionine binding site [chemical binding]; other site
243230006405	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
243230006406	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
243230006407	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
243230006408	active site
243230006409	FMN binding site [chemical binding]; other site
243230006410	substrate binding site [chemical binding]; other site
243230006411	homotetramer interface [polypeptide binding]; other site
243230006412	catalytic residue [active]
243230006413	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
243230006414	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
243230006415	Walker A/P-loop; other site
243230006416	ATP binding site [chemical binding]; other site
243230006417	Q-loop/lid; other site
243230006418	ABC transporter signature motif; other site
243230006419	Walker B; other site
243230006420	D-loop; other site
243230006421	H-loop/switch region; other site
243230006422	Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144
243230006423	ATP-grasp domain; Region: ATP-grasp_4; cl17255
243230006424	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
243230006425	putative homodimer interface [polypeptide binding]; other site
243230006426	putative active site pocket [active]
243230006427	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
243230006428	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
243230006429	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
243230006430	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243230006431	dimer interface [polypeptide binding]; other site
243230006432	conserved gate region; other site
243230006433	putative PBP binding loops; other site
243230006434	ABC-ATPase subunit interface; other site
243230006435	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
243230006436	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
243230006437	Walker A/P-loop; other site
243230006438	ATP binding site [chemical binding]; other site
243230006439	Q-loop/lid; other site
243230006440	ABC transporter signature motif; other site
243230006441	Walker B; other site
243230006442	D-loop; other site
243230006443	H-loop/switch region; other site
243230006444	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
243230006445	Divergent AAA domain; Region: AAA_4; pfam04326
243230006446	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
243230006447	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
243230006448	active site
243230006449	dimer interface [polypeptide binding]; other site
243230006450	Predicted transcriptional regulator [Transcription]; Region: COG1959
243230006451	Rrf2 family protein; Region: rrf2_super; TIGR00738
243230006452	UDP-glucose-4-epimerase GalE; Region: galE; TIGR01179
243230006453	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
243230006454	NAD binding site [chemical binding]; other site
243230006455	homodimer interface [polypeptide binding]; other site
243230006456	active site
243230006457	substrate binding site [chemical binding]; other site
243230006458	Uncharacterized conserved protein [Function unknown]; Region: COG1739
243230006459	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
243230006460	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
243230006461	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
243230006462	dimer interface [polypeptide binding]; other site
243230006463	ADP-ribose binding site [chemical binding]; other site
243230006464	active site
243230006465	nudix motif; other site
243230006466	metal binding site [ion binding]; metal-binding site
243230006467	Predicted membrane protein [Function unknown]; Region: COG1289
243230006468	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
243230006469	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
243230006470	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354
243230006471	putative metal binding site [ion binding]; other site
243230006472	Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718
243230006473	RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145
243230006474	ATP binding site [chemical binding]; other site
243230006475	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
243230006476	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
243230006477	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
243230006478	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
243230006479	ATP-grasp in the biosynthetic pathway with Ter operon; Region: ATPgrasp_Ter; pfam15632
243230006480	ATP-grasp domain; Region: ATP-grasp_4; cl17255
243230006481	Phosphoribosyl transferase; Region: PRTase_2; pfam15609
243230006482	TRSP domain C terminus to PRTase_2; Region: TRSP; pfam12500
243230006483	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
243230006484	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
243230006485	Uncharacterized conserved protein [Function unknown]; Region: COG2013
243230006486	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
243230006487	putative metal binding site [ion binding]; other site
243230006488	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
243230006489	putative metal binding site [ion binding]; other site
243230006490	Phosphoribosyl transferase (PRTase); Region: PRTase_1; pfam11202
243230006491	PELOTA RNA binding domain; Region: PELOTA_1; pfam15608
243230006492	C-C_Bond_Lyase of the TIM-Barrel fold; Region: C-C_Bond_Lyase; pfam15617
243230006493	tellurite resistance protein terB; Region: terB; cd07176
243230006494	putative metal binding site [ion binding]; other site
243230006495	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
243230006496	putative metal binding site [ion binding]; other site
243230006497	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
243230006498	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
243230006499	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
243230006500	putative metal binding site [ion binding]; other site
243230006501	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
243230006502	putative metal binding site [ion binding]; other site
243230006503	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
243230006504	putative metal binding site [ion binding]; other site
243230006505	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
243230006506	putative metal binding site [ion binding]; other site
243230006507	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899
243230006508	cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04135
243230006509	Protein of unknown function (DUF3383); Region: DUF3383; pfam11863
243230006510	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4696
243230006511	metal binding site [ion binding]; metal-binding site
243230006512	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
243230006513	active site
243230006514	metal binding site [ion binding]; metal-binding site
243230006515	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
243230006516	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
243230006517	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
243230006518	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
243230006519	active site
243230006520	PHP-associated; Region: PHP_C; pfam13263
243230006521	dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214
243230006522	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
243230006523	active site clefts [active]
243230006524	zinc binding site [ion binding]; other site
243230006525	dimer interface [polypeptide binding]; other site
243230006526	M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896
243230006527	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
243230006528	putative metal binding site [ion binding]; other site
243230006529	EF-hand domain pair; Region: EF-hand_7; pfam13499
243230006530	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
243230006531	Ca2+ binding site [ion binding]; other site
243230006532	hypothetical protein; Provisional; Region: PRK02395
243230006533	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
243230006534	putative active site [active]
243230006535	active site
243230006536	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
243230006537	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
243230006538	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
243230006539	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
243230006540	dimer interface [polypeptide binding]; other site
243230006541	catalytic triad [active]
243230006542	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
243230006543	PhoU domain; Region: PhoU; pfam01895
243230006544	PhoU domain; Region: PhoU; pfam01895
243230006545	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
243230006546	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243230006547	dimer interface [polypeptide binding]; other site
243230006548	phosphorylation site [posttranslational modification]
243230006549	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243230006550	ATP binding site [chemical binding]; other site
243230006551	Mg2+ binding site [ion binding]; other site
243230006552	G-X-G motif; other site
243230006553	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
243230006554	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243230006555	active site
243230006556	phosphorylation site [posttranslational modification]
243230006557	intermolecular recognition site; other site
243230006558	dimerization interface [polypeptide binding]; other site
243230006559	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
243230006560	DNA binding site [nucleotide binding]
243230006561	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
243230006562	putative hydrophobic ligand binding site [chemical binding]; other site
243230006563	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
243230006564	Putative lysophospholipase; Region: Hydrolase_4; cl19140
243230006565	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
243230006566	Predicted kinase [General function prediction only]; Region: COG4639
243230006567	AAA domain; Region: AAA_33; pfam13671
243230006568	Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423
243230006569	bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625
243230006570	active site
243230006571	metal binding site [ion binding]; metal-binding site
243230006572	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
243230006573	Predicted membrane protein [Function unknown]; Region: COG2311
243230006574	Protein of unknown function (DUF418); Region: DUF418; pfam04235
243230006575	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230006576	Coenzyme A binding pocket [chemical binding]; other site
243230006577	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230006578	Coenzyme A binding pocket [chemical binding]; other site
243230006579	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
243230006580	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
243230006581	TPP-binding site [chemical binding]; other site
243230006582	dimer interface [polypeptide binding]; other site
243230006583	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
243230006584	PYR/PP interface [polypeptide binding]; other site
243230006585	dimer interface [polypeptide binding]; other site
243230006586	TPP binding site [chemical binding]; other site
243230006587	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
243230006588	Domain of unknown function (DUF4440); Region: DUF4440; pfam14534
243230006589	Erythromycin esterase homolog [General function prediction only]; Region: COG2312
243230006590	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
243230006591	non-specific DNA binding site [nucleotide binding]; other site
243230006592	salt bridge; other site
243230006593	sequence-specific DNA binding site [nucleotide binding]; other site
243230006594	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
243230006595	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
243230006596	SRP54-type protein, GTPase domain; Region: SRP54; smart00962
243230006597	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
243230006598	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
243230006599	active site
243230006600	catalytic tetrad [active]
243230006601	Domain of unknown function (DUF4385); Region: DUF4385; pfam14328
243230006602	Ferritin-like domain; Region: Ferritin; pfam00210
243230006603	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
243230006604	dimerization interface [polypeptide binding]; other site
243230006605	DPS ferroxidase diiron center [ion binding]; other site
243230006606	ion pore; other site
243230006607	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
243230006608	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
243230006609	Methyltransferase domain; Region: Methyltransf_26; pfam13659
243230006610	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
243230006611	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243230006612	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243230006613	homodimer interface [polypeptide binding]; other site
243230006614	catalytic residue [active]
243230006615	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
243230006616	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
243230006617	ATP binding site [chemical binding]; other site
243230006618	substrate interface [chemical binding]; other site
243230006619	membrane protein; Provisional; Region: PRK14401
243230006620	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243230006621	Tetratricopeptide repeat; Region: TPR_12; pfam13424
243230006622	binding surface
243230006623	TPR motif; other site
243230006624	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
243230006625	nudix motif; other site
243230006626	AAA domain; Region: AAA_17; cl19128
243230006627	Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563
243230006628	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243230006629	S-adenosylmethionine binding site [chemical binding]; other site
243230006630	excinuclease ABC subunit B; Provisional; Region: PRK05298
243230006631	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
243230006632	ATP binding site [chemical binding]; other site
243230006633	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243230006634	nucleotide binding region [chemical binding]; other site
243230006635	ATP-binding site [chemical binding]; other site
243230006636	Ultra-violet resistance protein B; Region: UvrB; pfam12344
243230006637	UvrB/uvrC motif; Region: UVR; pfam02151
243230006638	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
243230006639	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243230006640	dimer interface [polypeptide binding]; other site
243230006641	conserved gate region; other site
243230006642	putative PBP binding loops; other site
243230006643	ABC-ATPase subunit interface; other site
243230006644	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243230006645	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243230006646	substrate binding pocket [chemical binding]; other site
243230006647	membrane-bound complex binding site; other site
243230006648	hinge residues; other site
243230006649	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
243230006650	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
243230006651	NAD binding site [chemical binding]; other site
243230006652	catalytic Zn binding site [ion binding]; other site
243230006653	structural Zn binding site [ion binding]; other site
243230006654	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
243230006655	Sulfate transporter family; Region: Sulfate_transp; cl19250
243230006656	dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571
243230006657	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
243230006658	dsRNA binding site [nucleotide binding]; other site
243230006659	Predicted endonuclease distantly related to archaeal Holliday junction resolvase [DNA replication, recombination, and repair]; Region: COG0792
243230006660	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
243230006661	ABC-ATPase subunit  interface; other site
243230006662	dimer interface [polypeptide binding]; other site
243230006663	putative PBP binding regions; other site
243230006664	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
243230006665	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
243230006666	A/G-specific adenine glycosylase; Region: mutY; TIGR01084
243230006667	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
243230006668	minor groove reading motif; other site
243230006669	helix-hairpin-helix signature motif; other site
243230006670	substrate binding pocket [chemical binding]; other site
243230006671	active site
243230006672	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
243230006673	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
243230006674	DNA binding and oxoG recognition site [nucleotide binding]
243230006675	DNA binding domains of BfiI, EcoRII and plant B3 proteins; Region: BfiI_C_EcoRII_N_B3; cl15242
243230006676	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
243230006677	AsnC family; Region: AsnC_trans_reg; pfam01037
243230006678	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
243230006679	putative ADP-ribose binding site [chemical binding]; other site
243230006680	putative active site [active]
243230006681	Guanylate kinase; Region: Guanylate_kin; pfam00625
243230006682	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
243230006683	catalytic site [active]
243230006684	G-X2-G-X-G-K; other site
243230006685	Herpesvirus UL25 family; Region: Herpes_UL25; pfam01499
243230006686	Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101
243230006687	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
243230006688	dimerization interface 3.5A [polypeptide binding]; other site
243230006689	active site
243230006690	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
243230006691	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
243230006692	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
243230006693	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
243230006694	Peptidase family M23; Region: Peptidase_M23; pfam01551
243230006695	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084
243230006696	putative catalytic site [active]
243230006697	putative metal binding site [ion binding]; other site
243230006698	putative phosphate binding site [ion binding]; other site
243230006699	CutA1 divalent ion tolerance protein; Region: CutA1; pfam03091
243230006700	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
243230006701	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
243230006702	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
243230006703	active site
243230006704	Tetratricopeptide repeat; Region: TPR_12; pfam13424
243230006705	Tetratricopeptide repeat; Region: TPR_12; pfam13424
243230006706	Tetratricopeptide repeat; Region: TPR_12; pfam13424
243230006707	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243230006708	metal binding site [ion binding]; metal-binding site
243230006709	active site
243230006710	I-site; other site
243230006711	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243230006712	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
243230006713	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
243230006714	motif 1; other site
243230006715	active site
243230006716	motif 2; other site
243230006717	motif 3; other site
243230006718	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
243230006719	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
243230006720	Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845
243230006721	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243230006722	H+ Antiporter protein; Region: 2A0121; TIGR00900
243230006723	putative substrate translocation pore; other site
243230006724	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
243230006725	Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774
243230006726	DNA binding residues [nucleotide binding]
243230006727	putative dimer interface [polypeptide binding]; other site
243230006728	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243230006729	Major Facilitator Superfamily; Region: MFS_1; pfam07690
243230006730	putative substrate translocation pore; other site
243230006731	GTP-binding protein Der; Reviewed; Region: PRK00093
243230006732	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
243230006733	G1 box; other site
243230006734	GTP/Mg2+ binding site [chemical binding]; other site
243230006735	Switch I region; other site
243230006736	G2 box; other site
243230006737	Switch II region; other site
243230006738	G3 box; other site
243230006739	G4 box; other site
243230006740	G5 box; other site
243230006741	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
243230006742	G1 box; other site
243230006743	GTP/Mg2+ binding site [chemical binding]; other site
243230006744	Switch I region; other site
243230006745	G2 box; other site
243230006746	G3 box; other site
243230006747	Switch II region; other site
243230006748	G4 box; other site
243230006749	G5 box; other site
243230006750	KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714
243230006751	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951
243230006752	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
243230006753	active site
243230006754	Uncharacterized enzyme involved in pigment biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IndA; COG2313
243230006755	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
243230006756	DNA binding residues [nucleotide binding]
243230006757	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
243230006758	substrate binding site [chemical binding]; other site
243230006759	ATP binding site [chemical binding]; other site
243230006760	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
243230006761	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
243230006762	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
243230006763	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
243230006764	Walker A/P-loop; other site
243230006765	ATP binding site [chemical binding]; other site
243230006766	Q-loop/lid; other site
243230006767	ABC transporter signature motif; other site
243230006768	Walker B; other site
243230006769	D-loop; other site
243230006770	H-loop/switch region; other site
243230006771	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
243230006772	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
243230006773	active site
243230006774	catalytic tetrad [active]
243230006775	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934
243230006776	OstA-like protein; Region: OstA; cl00844
243230006777	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
243230006778	OstA-like protein; Region: OstA; cl00844
243230006779	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
243230006780	CoenzymeA binding site [chemical binding]; other site
243230006781	subunit interaction site [polypeptide binding]; other site
243230006782	PHB binding site; other site
243230006783	Subtilase family; Region: Peptidase_S8; pfam00082
243230006784	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
243230006785	active site
243230006786	catalytic residues [active]
243230006787	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
243230006788	Transposase IS200 like; Region: Y1_Tnp; pfam01797
243230006789	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
243230006790	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
243230006791	Probable transposase; Region: OrfB_IS605; pfam01385
243230006792	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
243230006793	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
243230006794	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
243230006795	catalytic residues [active]
243230006796	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
243230006797	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
243230006798	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243230006799	active site
243230006800	phosphorylation site [posttranslational modification]
243230006801	intermolecular recognition site; other site
243230006802	dimerization interface [polypeptide binding]; other site
243230006803	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
243230006804	DNA binding site [nucleotide binding]
243230006805	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243230006806	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243230006807	dimerization interface [polypeptide binding]; other site
243230006808	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243230006809	dimer interface [polypeptide binding]; other site
243230006810	phosphorylation site [posttranslational modification]
243230006811	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243230006812	ATP binding site [chemical binding]; other site
243230006813	Mg2+ binding site [ion binding]; other site
243230006814	G-X-G motif; other site
243230006815	MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804
243230006816	active site
243230006817	Ferredoxin [Energy production and conversion]; Region: COG1146
243230006818	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
243230006819	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
243230006820	active site
243230006821	metal binding site [ion binding]; metal-binding site
243230006822	AAA ATPase domain; Region: AAA_16; pfam13191
243230006823	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
243230006824	DNA polymerase III subunit delta'; Validated; Region: PRK08485
243230006825	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
243230006826	putative active site [active]
243230006827	putative FMN binding site [chemical binding]; other site
243230006828	putative substrate binding site [chemical binding]; other site
243230006829	putative catalytic residue [active]
243230006830	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230006831	Coenzyme A binding pocket [chemical binding]; other site
243230006832	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230006833	Coenzyme A binding pocket [chemical binding]; other site
243230006834	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
243230006835	Ion channel; Region: Ion_trans_2; pfam07885
243230006836	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
243230006837	TrkA-N domain; Region: TrkA_N; pfam02254
243230006838	TrkA-C domain; Region: TrkA_C; pfam02080
243230006839	competence damage-inducible protein A; Provisional; Region: PRK00549
243230006840	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
243230006841	putative MPT binding site; other site
243230006842	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
243230006843	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
243230006844	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
243230006845	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
243230006846	recombinase A; Provisional; Region: recA; PRK09354
243230006847	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
243230006848	hexamer interface [polypeptide binding]; other site
243230006849	Walker A motif; other site
243230006850	ATP binding site [chemical binding]; other site
243230006851	Walker B motif; other site
243230006852	BirA biotin operon repressor domain; Region: birA_repr_reg; TIGR00122
243230006853	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
243230006854	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
243230006855	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
243230006856	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
243230006857	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
243230006858	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
243230006859	putative active site [active]
243230006860	putative metal binding site [ion binding]; other site
243230006861	8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858
243230006862	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
243230006863	substrate-cofactor binding pocket; other site
243230006864	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243230006865	catalytic residue [active]
243230006866	Roadblock/LC7 domain; Region: Robl_LC7; pfam03259
243230006867	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
243230006868	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
243230006869	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
243230006870	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
243230006871	domain interfaces; other site
243230006872	active site
243230006873	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
243230006874	active site
243230006875	homotetramer interface [polypeptide binding]; other site
243230006876	homodimer interface [polypeptide binding]; other site
243230006877	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
243230006878	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
243230006879	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
243230006880	dimer interface [polypeptide binding]; other site
243230006881	motif 1; other site
243230006882	active site
243230006883	motif 2; other site
243230006884	motif 3; other site
243230006885	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
243230006886	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230006887	Coenzyme A binding pocket [chemical binding]; other site
243230006888	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_11; cd04669
243230006889	nudix motif; other site
243230006890	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
243230006891	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
243230006892	putative tRNA-binding site [nucleotide binding]; other site
243230006893	B3/4 domain; Region: B3_4; pfam03483
243230006894	tRNA synthetase B5 domain; Region: B5; smart00874
243230006895	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
243230006896	dimer interface [polypeptide binding]; other site
243230006897	motif 1; other site
243230006898	motif 3; other site
243230006899	motif 2; other site
243230006900	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
243230006901	Tetratricopeptide repeat; Region: TPR_12; pfam13424
243230006902	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957
243230006903	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
243230006904	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
243230006905	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
243230006906	active site
243230006907	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
243230006908	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
243230006909	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
243230006910	ligand binding site [chemical binding]; other site
243230006911	flexible hinge region; other site
243230006912	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
243230006913	putative switch regulator; other site
243230006914	non-specific DNA interactions [nucleotide binding]; other site
243230006915	DNA binding site [nucleotide binding]
243230006916	sequence specific DNA binding site [nucleotide binding]; other site
243230006917	putative cAMP binding site [chemical binding]; other site
243230006918	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
243230006919	Ligand Binding Site [chemical binding]; other site
243230006920	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
243230006921	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
243230006922	dimer interface [polypeptide binding]; other site
243230006923	NAD binding site [chemical binding]; other site
243230006924	substrate binding site [chemical binding]; other site
243230006925	tetramer (dimer of dimers) interface [polypeptide binding]; other site
243230006926	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
243230006927	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
243230006928	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
243230006929	putative cation:proton antiport protein; Provisional; Region: PRK10669
243230006930	TrkA-N domain; Region: TrkA_N; pfam02254
243230006931	Predicted membrane protein [Function unknown]; Region: COG2860
243230006932	UPF0126 domain; Region: UPF0126; pfam03458
243230006933	UPF0126 domain; Region: UPF0126; pfam03458
243230006934	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
243230006935	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
243230006936	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
243230006937	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
243230006938	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
243230006939	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
243230006940	putative active site [active]
243230006941	catalytic residue [active]
243230006942	Ribonucleotide reductase, alpha subunit [Nucleotide transport and metabolism]; Region: NrdA; COG0209
243230006943	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
243230006944	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
243230006945	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
243230006946	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
243230006947	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
243230006948	protein-splicing catalytic site; other site
243230006949	thioester formation/cholesterol transfer; other site
243230006950	LAGLIDADG-like domain; Region: LAGLIDADG_3; pfam14528
243230006951	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
243230006952	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
243230006953	TSCPD domain; Region: TSCPD; pfam12637
243230006954	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
243230006955	Uncharacterized conserved protein, YhbC family [Function unknown]; Region: COG0782
243230006956	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
243230006957	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243230006958	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
243230006959	Predicted integral membrane protein [Function unknown]; Region: COG5637
243230006960	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
243230006961	putative hydrophobic ligand binding site [chemical binding]; other site
243230006962	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
243230006963	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
243230006964	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
243230006965	Walker A/P-loop; other site
243230006966	ATP binding site [chemical binding]; other site
243230006967	Q-loop/lid; other site
243230006968	ABC transporter signature motif; other site
243230006969	Walker B; other site
243230006970	D-loop; other site
243230006971	H-loop/switch region; other site
243230006972	bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
243230006973	N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128
243230006974	substrate binding site [chemical binding]; other site
243230006975	dimer interface [polypeptide binding]; other site
243230006976	NADP binding site [chemical binding]; other site
243230006977	catalytic residues [active]
243230006978	MaoC_C  The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452
243230006979	substrate binding site [chemical binding]; other site
243230006980	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
243230006981	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
243230006982	phenylacetate-CoA oxygenase, PaaI subunit; Region: PA_CoA_Oxy3; TIGR02158
243230006983	Uncharacterized enzyme of phenylacetate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3460
243230006984	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
243230006985	S-ribosylhomocysteinase; Provisional; Region: PRK02260
243230006986	lipoprotein signal peptidase; Provisional; Region: PRK14777
243230006987	Predicted membrane protein [Function unknown]; Region: COG2261
243230006988	Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083
243230006989	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
243230006990	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
243230006991	Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240
243230006992	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
243230006993	metal ion-dependent adhesion site (MIDAS); other site
243230006994	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
243230006995	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
243230006996	EamA-like transporter family; Region: EamA; pfam00892
243230006997	EamA-like transporter family; Region: EamA; pfam00892
243230006998	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
243230006999	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
243230007000	active site
243230007001	metal binding site [ion binding]; metal-binding site
243230007002	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
243230007003	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243230007004	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
243230007005	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
243230007006	Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase [General function prediction only]; Region: COG3576
243230007007	PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
243230007008	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
243230007009	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
243230007010	oligomer interface [polypeptide binding]; other site
243230007011	putative Cl binding site [ion binding]; other site
243230007012	aspartate ring; other site
243230007013	basic sphincter; other site
243230007014	hydrophobic gate; other site
243230007015	periplasmic entrance; other site
243230007016	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
243230007017	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971
243230007018	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
243230007019	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
243230007020	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243230007021	Walker A/P-loop; other site
243230007022	ATP binding site [chemical binding]; other site
243230007023	Q-loop/lid; other site
243230007024	ABC transporter signature motif; other site
243230007025	Walker B; other site
243230007026	D-loop; other site
243230007027	H-loop/switch region; other site
243230007028	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
243230007029	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243230007030	S-adenosylmethionine binding site [chemical binding]; other site
243230007031	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
243230007032	CoenzymeA binding site [chemical binding]; other site
243230007033	subunit interaction site [polypeptide binding]; other site
243230007034	PHB binding site; other site
243230007035	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
243230007036	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
243230007037	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
243230007038	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
243230007039	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
243230007040	active site
243230007041	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14963
243230007042	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243230007043	Walker A motif; other site
243230007044	ATP binding site [chemical binding]; other site
243230007045	Walker B motif; other site
243230007046	arginine finger; other site
243230007047	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
243230007048	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
243230007049	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
243230007050	Chromate transporter; Region: Chromate_transp; cl17781
243230007051	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
243230007052	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243230007053	active site
243230007054	phosphorylation site [posttranslational modification]
243230007055	intermolecular recognition site; other site
243230007056	dimerization interface [polypeptide binding]; other site
243230007057	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
243230007058	DNA binding site [nucleotide binding]
243230007059	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243230007060	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243230007061	dimer interface [polypeptide binding]; other site
243230007062	phosphorylation site [posttranslational modification]
243230007063	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243230007064	ATP binding site [chemical binding]; other site
243230007065	Mg2+ binding site [ion binding]; other site
243230007066	G-X-G motif; other site
243230007067	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
243230007068	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
243230007069	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
243230007070	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243230007071	active site
243230007072	phosphorylation site [posttranslational modification]
243230007073	intermolecular recognition site; other site
243230007074	dimerization interface [polypeptide binding]; other site
243230007075	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
243230007076	DNA binding site [nucleotide binding]
243230007077	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243230007078	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
243230007079	putative active site [active]
243230007080	heme pocket [chemical binding]; other site
243230007081	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243230007082	putative active site [active]
243230007083	heme pocket [chemical binding]; other site
243230007084	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243230007085	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
243230007086	putative active site [active]
243230007087	heme pocket [chemical binding]; other site
243230007088	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243230007089	dimer interface [polypeptide binding]; other site
243230007090	phosphorylation site [posttranslational modification]
243230007091	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243230007092	ATP binding site [chemical binding]; other site
243230007093	Mg2+ binding site [ion binding]; other site
243230007094	G-X-G motif; other site
243230007095	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
243230007096	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243230007097	active site
243230007098	phosphorylation site [posttranslational modification]
243230007099	intermolecular recognition site; other site
243230007100	dimerization interface [polypeptide binding]; other site
243230007101	Predicted hydrolase (HD superfamily) [General function prediction only]; Region: COG2316
243230007102	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
243230007103	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
243230007104	active site
243230007105	Zn binding site [ion binding]; other site
243230007106	Probable transposase; Region: OrfB_IS605; pfam01385
243230007107	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
243230007108	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
243230007109	DDE superfamily endonuclease; Region: DDE_3; pfam13358
243230007110	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
243230007111	bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379
243230007112	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional proteins, also containing a Nudix hydrolase domain; Region: NMNAT_Nudix; cd02168
243230007113	active site
243230007114	(T/H)XGH motif; other site
243230007115	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
243230007116	nudix motif; other site
243230007117	Predicted permeases [General function prediction only]; Region: COG0795
243230007118	Predicted permeases [General function prediction only]; Region: COG0795
243230007119	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
243230007120	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230007121	Coenzyme A binding pocket [chemical binding]; other site
243230007122	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
243230007123	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
243230007124	putative active site [active]
243230007125	catalytic triad [active]
243230007126	putative dimer interface [polypeptide binding]; other site
243230007127	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
243230007128	active site
243230007129	catalytic residues [active]
243230007130	metal binding site [ion binding]; metal-binding site
243230007131	Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223
243230007132	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
243230007133	putative active site [active]
243230007134	substrate binding site [chemical binding]; other site
243230007135	putative cosubstrate binding site; other site
243230007136	catalytic site [active]
243230007137	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
243230007138	substrate binding site [chemical binding]; other site
243230007139	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
243230007140	EamA-like transporter family; Region: EamA; cl17759
243230007141	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
243230007142	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
243230007143	minor groove reading motif; other site
243230007144	helix-hairpin-helix signature motif; other site
243230007145	active site
243230007146	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
243230007147	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318
243230007148	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
243230007149	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
243230007150	FMN binding site [chemical binding]; other site
243230007151	active site
243230007152	catalytic residues [active]
243230007153	substrate binding site [chemical binding]; other site
243230007154	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
243230007155	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
243230007156	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
243230007157	nucleotide binding site [chemical binding]; other site
243230007158	N-acetyl-L-glutamate binding site [chemical binding]; other site
243230007159	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
243230007160	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
243230007161	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
243230007162	Fruit fly transformer protein; Region: Transformer; pfam06495
243230007163	HRDC domain; Region: HRDC; pfam00570
243230007164	Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475
243230007165	active site
243230007166	dimer interface [polypeptide binding]; other site
243230007167	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
243230007168	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
243230007169	DNA binding residues [nucleotide binding]
243230007170	drug binding residues [chemical binding]; other site
243230007171	dimer interface [polypeptide binding]; other site
243230007172	Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151
243230007173	putative homodimer interface [polypeptide binding]; other site
243230007174	putative homotetramer interface [polypeptide binding]; other site
243230007175	allosteric switch controlling residues; other site
243230007176	putative metal binding site [ion binding]; other site
243230007177	putative homodimer-homodimer interface [polypeptide binding]; other site
243230007178	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544
243230007179	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
243230007180	metal-binding site [ion binding]
243230007181	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
243230007182	metal-binding site [ion binding]
243230007183	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
243230007184	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
243230007185	metal-binding site [ion binding]
243230007186	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
243230007187	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243230007188	motif II; other site
243230007189	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
243230007190	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
243230007191	non-specific DNA binding site [nucleotide binding]; other site
243230007192	salt bridge; other site
243230007193	sequence-specific DNA binding site [nucleotide binding]; other site
243230007194	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
243230007195	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
243230007196	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
243230007197	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243230007198	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243230007199	homodimer interface [polypeptide binding]; other site
243230007200	catalytic residue [active]
243230007201	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
243230007202	hypothetical protein; Provisional; Region: PRK12705
243230007203	KH domain; Region: KH_1; pfam00013
243230007204	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243230007205	Zn2+ binding site [ion binding]; other site
243230007206	Mg2+ binding site [ion binding]; other site
243230007207	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
243230007208	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
243230007209	Cl binding site [ion binding]; other site
243230007210	oligomer interface [polypeptide binding]; other site
243230007211	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
243230007212	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl19519
243230007213	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
243230007214	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
243230007215	catalytic residue [active]
243230007216	Uncharacterized conserved protein [Function unknown]; Region: COG0327
243230007217	Predicted kinase [General function prediction only]; Region: COG0645
243230007218	AAA domain; Region: AAA_33; pfam13671
243230007219	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
243230007220	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
243230007221	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
243230007222	Walker A/P-loop; other site
243230007223	ATP binding site [chemical binding]; other site
243230007224	Q-loop/lid; other site
243230007225	ABC transporter signature motif; other site
243230007226	Walker B; other site
243230007227	D-loop; other site
243230007228	H-loop/switch region; other site
243230007229	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
243230007230	acetyl-CoA synthetase; Provisional; Region: PRK00174
243230007231	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
243230007232	active site
243230007233	CoA binding site [chemical binding]; other site
243230007234	acyl-activating enzyme (AAE) consensus motif; other site
243230007235	AMP binding site [chemical binding]; other site
243230007236	acetate binding site [chemical binding]; other site
243230007237	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
243230007238	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
243230007239	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
243230007240	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
243230007241	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
243230007242	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
243230007243	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
243230007244	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
243230007245	substrate binding site [chemical binding]; other site
243230007246	oxyanion hole (OAH) forming residues; other site
243230007247	trimer interface [polypeptide binding]; other site
243230007248	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
243230007249	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
243230007250	acetyl-CoA acetyltransferase; Provisional; Region: PRK07661
243230007251	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
243230007252	dimer interface [polypeptide binding]; other site
243230007253	active site
243230007254	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
243230007255	DNA binding residues [nucleotide binding]
243230007256	DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [Transcription]; Region: RpoD; COG0568
243230007257	HB1, ASXL, restriction endonuclease HTH domain; Region: HARE-HTH; cl01319
243230007258	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
243230007259	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
243230007260	FOG: WD40 repeat [General function prediction only]; Region: COG2319
243230007261	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
243230007262	Cytochrome c553 [Energy production and conversion]; Region: COG2863
243230007263	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
243230007264	Cytochrome c; Region: Cytochrom_C; pfam00034
243230007265	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
243230007266	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243230007267	dimer interface [polypeptide binding]; other site
243230007268	conserved gate region; other site
243230007269	putative PBP binding loops; other site
243230007270	ABC-ATPase subunit interface; other site
243230007271	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243230007272	dimer interface [polypeptide binding]; other site
243230007273	conserved gate region; other site
243230007274	putative PBP binding loops; other site
243230007275	ABC-ATPase subunit interface; other site
243230007276	putative trifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta/ferritin domain-containing protein; Provisional; Region: PRK12775
243230007277	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
243230007278	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243230007279	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
243230007280	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
243230007281	metal binding site [ion binding]; metal-binding site
243230007282	dimer interface [polypeptide binding]; other site
243230007283	DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758
243230007284	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
243230007285	catalytic residues [active]
243230007286	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
243230007287	UDP-N-acetylmuramoylalanine--D-glutamate ligase; Region: murD; TIGR01087
243230007288	NAD binding site [chemical binding]; other site
243230007289	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
243230007290	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
243230007291	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243230007292	metal binding site [ion binding]; metal-binding site
243230007293	active site
243230007294	I-site; other site
243230007295	Nucleoside diphosphate kinase; Region: NDK; pfam00334
243230007296	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
243230007297	active site
243230007298	multimer interface [polypeptide binding]; other site
243230007299	Transcriptional regulators [Transcription]; Region: PurR; COG1609
243230007300	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
243230007301	DNA binding site [nucleotide binding]
243230007302	domain linker motif; other site
243230007303	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279
243230007304	putative dimerization interface [polypeptide binding]; other site
243230007305	putative ligand binding site [chemical binding]; other site
243230007306	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243230007307	Major Facilitator Superfamily; Region: MFS_1; pfam07690
243230007308	putative substrate translocation pore; other site
243230007309	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
243230007310	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
243230007311	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
243230007312	putative active site [active]
243230007313	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
243230007314	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187
243230007315	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
243230007316	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
243230007317	dimer interface [polypeptide binding]; other site
243230007318	acyl-activating enzyme (AAE) consensus motif; other site
243230007319	putative active site [active]
243230007320	AMP binding site [chemical binding]; other site
243230007321	putative CoA binding site [chemical binding]; other site
243230007322	Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816
243230007323	enoyl-CoA hydratase; Provisional; Region: PRK08140
243230007324	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
243230007325	substrate binding site [chemical binding]; other site
243230007326	oxyanion hole (OAH) forming residues; other site
243230007327	trimer interface [polypeptide binding]; other site
243230007328	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
243230007329	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
243230007330	homotrimer interaction site [polypeptide binding]; other site
243230007331	putative active site [active]
243230007332	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
243230007333	active site
243230007334	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
243230007335	putative acyl-acceptor binding pocket; other site
243230007336	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
243230007337	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
243230007338	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
243230007339	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
243230007340	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
243230007341	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
243230007342	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
243230007343	Catalytic domain of Protein Kinases; Region: PKc; cd00180
243230007344	active site
243230007345	ATP binding site [chemical binding]; other site
243230007346	substrate binding site [chemical binding]; other site
243230007347	activation loop (A-loop); other site
243230007348	FOG: WD40-like repeat [Function unknown]; Region: COG1520
243230007349	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
243230007350	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
243230007351	Trp docking motif [polypeptide binding]; other site
243230007352	active site
243230007353	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
243230007354	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
243230007355	DNA binding residues [nucleotide binding]
243230007356	Fe-S oxidoreductase, related to NifB/MoaA family [Energy production and conversion]; Region: COG1625
243230007357	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
243230007358	Protein of unknown function (DUF512); Region: DUF512; pfam04459
243230007359	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
243230007360	Putative lysophospholipase; Region: Hydrolase_4; cl19140
243230007361	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
243230007362	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
243230007363	metal binding site [ion binding]; metal-binding site
243230007364	ribosomal protein L28; Region: L28; TIGR00009
243230007365	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
243230007366	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
243230007367	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
243230007368	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
243230007369	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
243230007370	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
243230007371	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
243230007372	active site residue [active]
243230007373	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
243230007374	active site residue [active]
243230007375	Peptidases of the G1 family and homologs that might lack peptidase activity; Region: Peptidase_G1_like; cl03371
243230007376	Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320
243230007377	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
243230007378	putative active site; other site
243230007379	catalytic triad [active]
243230007380	putative dimer interface [polypeptide binding]; other site
243230007381	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
243230007382	YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107
243230007383	Moco binding site; other site
243230007384	metal coordination site [ion binding]; other site
243230007385	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
243230007386	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
243230007387	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
243230007388	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
243230007389	Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742
243230007390	FeoA domain; Region: FeoA; pfam04023
243230007391	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
243230007392	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
243230007393	active site
243230007394	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
243230007395	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
243230007396	active site
243230007397	Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283
243230007398	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
243230007399	CMP-binding site; other site
243230007400	The sites determining sugar specificity; other site
243230007401	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
243230007402	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
243230007403	FMN binding site [chemical binding]; other site
243230007404	substrate binding site [chemical binding]; other site
243230007405	putative catalytic residue [active]
243230007406	Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248
243230007407	Glutamyl-tRNA reductase [Coenzyme metabolism]; Region: HemA; COG0373
243230007408	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
243230007409	tRNA; other site
243230007410	putative tRNA binding site [nucleotide binding]; other site
243230007411	putative NADP binding site [chemical binding]; other site
243230007412	hypothetical protein; Validated; Region: PRK00110
243230007413	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
243230007414	Putative lysophospholipase; Region: Hydrolase_4; cl19140
243230007415	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
243230007416	Putative lysophospholipase; Region: Hydrolase_4; cl19140
243230007417	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
243230007418	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
243230007419	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
243230007420	dimerization interface [polypeptide binding]; other site
243230007421	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
243230007422	substrate binding site [chemical binding]; other site
243230007423	ATP binding site [chemical binding]; other site
243230007424	Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) [Translation, ribosomal structure and biogenesis]; Region: GatB; COG0064
243230007425	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
243230007426	GatB domain; Region: GatB_Yqey; smart00845
243230007427	Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947
243230007428	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243230007429	active site
243230007430	phosphorylation site [posttranslational modification]
243230007431	intermolecular recognition site; other site
243230007432	dimerization interface [polypeptide binding]; other site
243230007433	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
243230007434	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
243230007435	conserved hypothetical protein; Region: TIGR03833
243230007436	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243230007437	S-adenosylmethionine binding site [chemical binding]; other site
243230007438	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
243230007439	catalytic core [active]
243230007440	Protein of unknown function (DUF2975); Region: DUF2975; pfam11188
243230007441	Domain of unknown function (DUF1772); Region: DUF1772; cl12097
243230007442	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
243230007443	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
243230007444	Cysteine-rich domain; Region: CCG; pfam02754
243230007445	Cysteine-rich domain; Region: CCG; pfam02754
243230007446	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
243230007447	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
243230007448	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
243230007449	active site
243230007450	metal binding site [ion binding]; metal-binding site
243230007451	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
243230007452	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
243230007453	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
243230007454	active site
243230007455	HIGH motif; other site
243230007456	KMSK motif region; other site
243230007457	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
243230007458	tRNA binding surface [nucleotide binding]; other site
243230007459	anticodon binding site; other site
243230007460	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
243230007461	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
243230007462	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
243230007463	trimer interface [polypeptide binding]; other site
243230007464	dimer interface [polypeptide binding]; other site
243230007465	putative active site [active]
243230007466	Protein of unknown function (DUF342); Region: DUF342; cl19219
243230007467	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
243230007468	non-specific DNA binding site [nucleotide binding]; other site
243230007469	salt bridge; other site
243230007470	sequence-specific DNA binding site [nucleotide binding]; other site
243230007471	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
243230007472	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
243230007473	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
243230007474	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
243230007475	DHH family; Region: DHH; pfam01368
243230007476	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
243230007477	DHHA2 domain; Region: DHHA2; pfam02833
243230007478	S-layer homology domain; Region: SLH; pfam00395
243230007479	Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654
243230007480	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
243230007481	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
243230007482	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
243230007483	cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350
243230007484	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
243230007485	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243230007486	Zn2+ binding site [ion binding]; other site
243230007487	Mg2+ binding site [ion binding]; other site
243230007488	malate dehydrogenase; Provisional; Region: PRK13529
243230007489	Malic enzyme, N-terminal domain; Region: malic; pfam00390
243230007490	Malic enzyme, NAD binding domain; Region: Malic_M; pfam03949
243230007491	NAD(P) binding pocket [chemical binding]; other site
243230007492	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
243230007493	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
243230007494	minor groove reading motif; other site
243230007495	helix-hairpin-helix signature motif; other site
243230007496	substrate binding pocket [chemical binding]; other site
243230007497	active site
243230007498	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
243230007499	Exonuclease VII small subunit [DNA replication, recombination, and repair]; Region: XseB; COG1722
243230007500	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
243230007501	putative acyl-acceptor binding pocket; other site
243230007502	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
243230007503	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
243230007504	putative binding site residues; other site
243230007505	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
243230007506	ABC-ATPase subunit  interface; other site
243230007507	dimer interface [polypeptide binding]; other site
243230007508	putative PBP binding regions; other site
243230007509	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
243230007510	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
243230007511	Walker A/P-loop; other site
243230007512	ATP binding site [chemical binding]; other site
243230007513	Q-loop/lid; other site
243230007514	ABC transporter signature motif; other site
243230007515	Walker B; other site
243230007516	D-loop; other site
243230007517	H-loop/switch region; other site
243230007518	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
243230007519	dimer interface [polypeptide binding]; other site
243230007520	[2Fe-2S] cluster binding site [ion binding]; other site
243230007521	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
243230007522	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
243230007523	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
243230007524	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
243230007525	putative NAD(P) binding site [chemical binding]; other site
243230007526	active site
243230007527	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl19825
243230007528	Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794
243230007529	active site
243230007530	dimer interface [polypeptide binding]; other site
243230007531	Uncharacterized conserved protein [Function unknown]; Region: COG0432
243230007532	Domain of unknown function (DUF4403); Region: DUF4403; pfam14356
243230007533	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
243230007534	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
243230007535	Predicted periplasmic protein [Function unknown]; Region: COG3698
243230007536	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
243230007537	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
243230007538	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
243230007539	substrate binding site; other site
243230007540	dimer interface; other site
243230007541	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14612
243230007542	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
243230007543	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
243230007544	zinc-ribbons; Region: zinc-ribbons_6; pfam07191
243230007545	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
243230007546	MoaE interaction surface [polypeptide binding]; other site
243230007547	MoeB interaction surface [polypeptide binding]; other site
243230007548	thiocarboxylated glycine; other site
243230007549	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
243230007550	MoaE homodimer interface [polypeptide binding]; other site
243230007551	MoaD interaction [polypeptide binding]; other site
243230007552	active site residues [active]
243230007553	Predicted thioesterase [General function prediction only]; Region: COG5496
243230007554	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
243230007555	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243230007556	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243230007557	substrate binding pocket [chemical binding]; other site
243230007558	membrane-bound complex binding site; other site
243230007559	hinge residues; other site
243230007560	glutaminyl-tRNA synthetase/YqeY domain fusion protein; Provisional; Region: PRK14703
243230007561	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
243230007562	active site
243230007563	HIGH motif; other site
243230007564	KMSKS motif; other site
243230007565	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
243230007566	GatB domain; Region: GatB_Yqey; pfam02637
243230007567	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
243230007568	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
243230007569	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243230007570	active site
243230007571	motif I; other site
243230007572	motif II; other site
243230007573	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
243230007574	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
243230007575	active site
243230007576	oligomerization interface [polypeptide binding]; other site
243230007577	metal binding site [ion binding]; metal-binding site
243230007578	Predicted membrane protein [Function unknown]; Region: COG2322
243230007579	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
243230007580	Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957
243230007581	putative active site [active]
243230007582	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
243230007583	The cupredoxin domain of Caa3 type Cytochrome c oxidase subunit II; Region: CuRO_CcO_Caa3_II; cd04213
243230007584	oligomer interface [polypeptide binding]; other site
243230007585	CuA binuclear center [ion binding]; other site
243230007586	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
243230007587	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
243230007588	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
243230007589	Subunit I/III interface [polypeptide binding]; other site
243230007590	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14618
243230007591	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
243230007592	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
243230007593	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
243230007594	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243230007595	S-adenosylmethionine binding site [chemical binding]; other site
243230007596	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
243230007597	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
243230007598	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
243230007599	Protein of unknown function (DUF3105); Region: DUF3105; pfam11303
243230007600	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370
243230007601	conserved hypothetical protein; Region: TIGR03492
243230007602	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
243230007603	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
243230007604	substrate binding pocket [chemical binding]; other site
243230007605	catalytic triad [active]
243230007606	fumarate hydratase; Reviewed; Region: fumC; PRK00485
243230007607	Class II fumarases; Region: Fumarase_classII; cd01362
243230007608	active site
243230007609	tetramer interface [polypeptide binding]; other site
243230007610	Predicted membrane protein [Function unknown]; Region: COG4709
243230007611	Transcriptional regulator PadR-like family; Region: PadR; cl17335
243230007612	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
243230007613	dimerization interface [polypeptide binding]; other site
243230007614	active site
243230007615	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
243230007616	catalytic motif [active]
243230007617	Zn binding site [ion binding]; other site
243230007618	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
243230007619	folate binding site [chemical binding]; other site
243230007620	NADP+ binding site [chemical binding]; other site
243230007621	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
243230007622	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
243230007623	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
243230007624	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
243230007625	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
243230007626	active site
243230007627	HIGH motif; other site
243230007628	dimer interface [polypeptide binding]; other site
243230007629	KMSKS motif; other site
243230007630	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
243230007631	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
243230007632	domain interfaces; other site
243230007633	active site
243230007634	enolase; Provisional; Region: eno; PRK00077
243230007635	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
243230007636	dimer interface [polypeptide binding]; other site
243230007637	metal binding site [ion binding]; metal-binding site
243230007638	substrate binding pocket [chemical binding]; other site
243230007639	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
243230007640	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
243230007641	P-loop; other site
243230007642	Magnesium ion binding site [ion binding]; other site
243230007643	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
243230007644	ParB-like nuclease domain; Region: ParB; smart00470
243230007645	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
243230007646	tetramerization interface [polypeptide binding]; other site
243230007647	NAD(P) binding site [chemical binding]; other site
243230007648	catalytic residues [active]
243230007649	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
243230007650	Ligand binding site; other site
243230007651	metal-binding site
243230007652	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
243230007653	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
243230007654	NAD binding site [chemical binding]; other site
243230007655	catalytic Zn binding site [ion binding]; other site
243230007656	structural Zn binding site [ion binding]; other site
243230007657	Predicted integral membrane protein [Function unknown]; Region: COG5637
243230007658	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
243230007659	putative hydrophobic ligand binding site [chemical binding]; other site
243230007660	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
243230007661	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
243230007662	Walker A/P-loop; other site
243230007663	ATP binding site [chemical binding]; other site
243230007664	Q-loop/lid; other site
243230007665	ABC transporter signature motif; other site
243230007666	Walker B; other site
243230007667	D-loop; other site
243230007668	H-loop/switch region; other site
243230007669	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
243230007670	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
243230007671	ABC-2 type transporter; Region: ABC2_membrane; cl17235
243230007672	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
243230007673	Histidine kinase; Region: HisKA_3; pfam07730
243230007674	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243230007675	ATP binding site [chemical binding]; other site
243230007676	Mg2+ binding site [ion binding]; other site
243230007677	G-X-G motif; other site
243230007678	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
243230007679	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243230007680	active site
243230007681	phosphorylation site [posttranslational modification]
243230007682	intermolecular recognition site; other site
243230007683	dimerization interface [polypeptide binding]; other site
243230007684	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
243230007685	DNA binding residues [nucleotide binding]
243230007686	dimerization interface [polypeptide binding]; other site
243230007687	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
243230007688	active site
243230007689	SAM binding site [chemical binding]; other site
243230007690	homodimer interface [polypeptide binding]; other site
243230007691	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
243230007692	active site
243230007693	hypothetical protein; Provisional; Region: PRK02395
243230007694	active site
243230007695	CbiX; Region: CbiX; pfam01903
243230007696	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
243230007697	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
243230007698	putative active site [active]
243230007699	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
243230007700	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
243230007701	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
243230007702	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
243230007703	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
243230007704	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
243230007705	ligand-binding site [chemical binding]; other site
243230007706	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
243230007707	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
243230007708	Active Sites [active]
243230007709	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
243230007710	ATP-sulfurylase; Region: ATPS; cd00517
243230007711	active site
243230007712	HXXH motif; other site
243230007713	flexible loop; other site
243230007714	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
243230007715	CoenzymeA binding site [chemical binding]; other site
243230007716	subunit interaction site [polypeptide binding]; other site
243230007717	PHB binding site; other site
243230007718	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
243230007719	CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409
243230007720	active site
243230007721	metal binding site [ion binding]; metal-binding site
243230007722	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
243230007723	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230007724	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
243230007725	Coenzyme A binding pocket [chemical binding]; other site
243230007726	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243230007727	Coenzyme A binding pocket [chemical binding]; other site
243230007728	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
243230007729	homotrimer interface [polypeptide binding]; other site
243230007730	Walker A motif; other site
243230007731	GTP binding site [chemical binding]; other site
243230007732	Walker B motif; other site
243230007733	Protein of unknown function (DUF3160); Region: DUF3160; pfam11369
243230007734	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
243230007735	putative active site [active]
243230007736	putative metal binding site [ion binding]; other site
243230007737	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
243230007738	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
243230007739	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243230007740	FeS/SAM binding site; other site
243230007741	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
243230007742	Domain of unknown function (DUF4274); Region: DUF4274; pfam14096
243230007743	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
243230007744	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
243230007745	inhibitor-cofactor binding pocket; inhibition site
243230007746	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243230007747	catalytic residue [active]
243230007748	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
243230007749	Glutamate binding site [chemical binding]; other site
243230007750	homodimer interface [polypeptide binding]; other site
243230007751	NAD binding site [chemical binding]; other site
243230007752	catalytic residues [active]
243230007753	G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189
243230007754	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
243230007755	substrate binding site; other site
243230007756	metal-binding site
243230007757	Oligomer interface; other site
243230007758	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
243230007759	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
243230007760	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
243230007761	Substrate binding site; other site
243230007762	Cupin domain; Region: Cupin_2; cl17218
243230007763	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
243230007764	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
243230007765	AAA domain; Region: AAA_31; pfam13614
243230007766	Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022
243230007767	CoA binding domain; Region: CoA_binding; cl17356
243230007768	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
243230007769	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
243230007770	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
243230007771	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
243230007772	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
243230007773	Probable Catalytic site; other site
243230007774	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
243230007775	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
243230007776	Probable Catalytic site; other site
243230007777	metal-binding site
243230007778	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
243230007779	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
243230007780	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
243230007781	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
243230007782	putative ADP-binding pocket [chemical binding]; other site
243230007783	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
243230007784	dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181
243230007785	NAD binding site [chemical binding]; other site
243230007786	substrate binding site [chemical binding]; other site
243230007787	homodimer interface [polypeptide binding]; other site
243230007788	active site
243230007789	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
243230007790	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
243230007791	substrate binding site; other site
243230007792	tetramer interface; other site
243230007793	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
243230007794	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
243230007795	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243230007796	NAD(P) binding site [chemical binding]; other site
243230007797	active site
243230007798	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
243230007799	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
243230007800	O-Antigen ligase; Region: Wzy_C; pfam04932
243230007801	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
243230007802	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
243230007803	active site
243230007804	substrate binding site [chemical binding]; other site
243230007805	metal binding site [ion binding]; metal-binding site
243230007806	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
243230007807	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057
243230007808	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243230007809	active site
243230007810	phosphorylation site [posttranslational modification]
243230007811	intermolecular recognition site; other site
243230007812	dimerization interface [polypeptide binding]; other site
243230007813	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
243230007814	PAS fold; Region: PAS_2; pfam08446
243230007815	GAF domain; Region: GAF; pfam01590
243230007816	Phytochrome region; Region: PHY; pfam00360
243230007817	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243230007818	ATP binding site [chemical binding]; other site
243230007819	Mg2+ binding site [ion binding]; other site
243230007820	G-X-G motif; other site
243230007821	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
243230007822	heme binding pocket [chemical binding]; other site
243230007823	heme ligand [chemical binding]; other site
243230007824	putative acyltransferase; Provisional; Region: PRK05790
243230007825	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
243230007826	dimer interface [polypeptide binding]; other site
243230007827	active site
243230007828	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
243230007829	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
243230007830	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
243230007831	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
243230007832	substrate binding site [chemical binding]; other site
243230007833	dimer interface [polypeptide binding]; other site
243230007834	ATP binding site [chemical binding]; other site
243230007835	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
243230007836	putative metal binding site [ion binding]; other site
243230007837	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
243230007838	active site
243230007839	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
243230007840	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
243230007841	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
243230007842	catalytic site [active]
243230007843	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243230007844	Major Facilitator Superfamily; Region: MFS_1; pfam07690
243230007845	putative substrate translocation pore; other site
243230007846	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
243230007847	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
243230007848	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
243230007849	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
243230007850	Subtilase family; Region: Peptidase_S8; pfam00082
243230007851	active site
243230007852	catalytic residues [active]
243230007853	Bacteriophage SPO1-encoded TF1 binds and bends DNA; Region: SPO1_TF1_like; cd14435
243230007854	putative DNA binding site [nucleotide binding]; other site
243230007855	dimer interface [polypeptide binding]; other site
243230007856	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
243230007857	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
243230007858	active site
243230007859	dimer interface [polypeptide binding]; other site
243230007860	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
243230007861	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
243230007862	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
243230007863	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
243230007864	Beta-Casp domain; Region: Beta-Casp; smart01027
243230007865	RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521
243230007866	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
243230007867	putative DNA binding site [nucleotide binding]; other site
243230007868	putative Zn2+ binding site [ion binding]; other site
243230007869	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
243230007870	dimerization interface [polypeptide binding]; other site
243230007871	putative DNA binding site [nucleotide binding]; other site
243230007872	putative Zn2+ binding site [ion binding]; other site
243230007873	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
243230007874	catalytic residues [active]
243230007875	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
243230007876	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
243230007877	metal-binding site [ion binding]
243230007878	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
243230007879	Soluble P-type ATPase [General function prediction only]; Region: COG4087
243230007880	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
243230007881	non-specific DNA binding site [nucleotide binding]; other site
243230007882	salt bridge; other site
243230007883	sequence-specific DNA binding site [nucleotide binding]; other site
243230007884	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
243230007885	Catalytic site [active]
243230007886	Helix-turn-helix domain; Region: HTH_28; pfam13518
243230007887	Winged helix-turn helix; Region: HTH_29; pfam13551
243230007888	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
243230007889	Integrase core domain; Region: rve; pfam00665
243230007890	Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842
243230007891	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243230007892	Walker A motif; other site
243230007893	ATP binding site [chemical binding]; other site
243230007894	Walker B motif; other site
243230007895	arginine finger; other site
243230007896	Helix-turn-helix domain; Region: HTH_20; pfam12840
243230007897	Protein of unknown function (DUF3486); Region: DUF3486; pfam11985
243230007898	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
243230007899	Terminase-like family; Region: Terminase_6; pfam03237
243230007900	Uncharacterized protein, homolog of phage Mu protein gp30 [Function unknown]; Region: COG2369
243230007901	phage putative head morphogenesis protein, SPP1 gp7 family; Region: phageSPP1_gp7; TIGR01641
243230007902	P22 coat protein - gene protein 5; Region: P22_CoatProtein; cl19542
243230007903	Bacteriophage HK97-gp10, putative tail-component; Region: HK97-gp10_like; pfam04883
243230007904	Phage-related minor tail protein [Function unknown]; Region: COG5280
243230007905	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
243230007906	MAEBL; Provisional; Region: PTZ00121
243230007907	Right handed beta helix region; Region: Beta_helix; pfam13229
243230007908	Right handed beta helix region; Region: Beta_helix; pfam13229
243230007909	Predicted chitinase [General function prediction only]; Region: COG3179
243230007910	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
243230007911	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
243230007912	Methyltransferase domain; Region: Methyltransf_26; pfam13659
243230007913	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
243230007914	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
243230007915	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
243230007916	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
243230007917	inhibitor-cofactor binding pocket; inhibition site
243230007918	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243230007919	catalytic residue [active]
243230007920	2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312
243230007921	Low molecular weight phosphatase family; Region: LMWPc; cd00115
243230007922	active site
243230007923	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
243230007924	active site
243230007925	metal binding site [ion binding]; metal-binding site
243230007926	Diadenosine tetraphosphatase and related serine/threonine protein phosphatases [Signal transduction mechanisms]; Region: ApaH; COG0639
243230007927	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
243230007928	Uncharacterized conserved protein [Function unknown]; Region: COG4715
243230007929	SWIM zinc finger; Region: SWIM; pfam04434
243230007930	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
243230007931	NAD binding site [chemical binding]; other site
243230007932	catalytic residues [active]
243230007933	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
243230007934	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
243230007935	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
243230007936	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
243230007937	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
243230007938	salt bridge; other site
243230007939	non-specific DNA binding site [nucleotide binding]; other site
243230007940	sequence-specific DNA binding site [nucleotide binding]; other site
243230007941	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
243230007942	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
243230007943	XdhC Rossmann domain; Region: XdhC_C; pfam13478
243230007944	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243230007945	S-adenosylmethionine binding site [chemical binding]; other site
243230007946	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
243230007947	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
243230007948	ATP binding site [chemical binding]; other site
243230007949	putative Mg++ binding site [ion binding]; other site
243230007950	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243230007951	nucleotide binding region [chemical binding]; other site
243230007952	ATP-binding site [chemical binding]; other site
243230007953	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
243230007954	active site
243230007955	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
243230007956	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
243230007957	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
243230007958	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672
243230007959	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
243230007960	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243230007961	putative PBP binding loops; other site
243230007962	ABC-ATPase subunit interface; other site
243230007963	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
243230007964	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
243230007965	Walker A/P-loop; other site
243230007966	ATP binding site [chemical binding]; other site
243230007967	Q-loop/lid; other site
243230007968	ABC transporter signature motif; other site
243230007969	Walker B; other site
243230007970	D-loop; other site
243230007971	H-loop/switch region; other site
243230007972	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
243230007973	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
243230007974	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243230007975	dimer interface [polypeptide binding]; other site
243230007976	conserved gate region; other site
243230007977	putative PBP binding loops; other site
243230007978	ABC-ATPase subunit interface; other site
243230007979	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
243230007980	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243230007981	active site
243230007982	phosphorylation site [posttranslational modification]
243230007983	intermolecular recognition site; other site
243230007984	dimerization interface [polypeptide binding]; other site
243230007985	tetracycline repressor protein TetR; Provisional; Region: PRK13756
243230007986	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
243230007987	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
243230007988	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293
243230007989	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
243230007990	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
243230007991	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
243230007992	Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152
243230007993	putative heme binding pocket [chemical binding]; other site
243230007994	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
243230007995	Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221
243230007996	active sites [active]
243230007997	tetramer interface [polypeptide binding]; other site
243230007998	imidazolonepropionase; Region: hutI; TIGR01224
243230007999	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
243230008000	active site
243230008001	Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589
243230008002	oligomer interface [polypeptide binding]; other site
243230008003	active site
243230008004	Mn binding site [ion binding]; other site
243230008005	Tannase and feruloyl esterase; Region: Tannase; pfam07519
243230008006	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
243230008007	urocanate hydratase; Region: hutU; TIGR01228
243230008008	Transcriptional regulator [Transcription]; Region: IclR; COG1414
243230008009	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
243230008010	Bacterial transcriptional regulator; Region: IclR; pfam01614
243230008011	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
243230008012	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
243230008013	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
243230008014	dimer interface [polypeptide binding]; other site
243230008015	active site
243230008016	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
243230008017	dimer interface [polypeptide binding]; other site
243230008018	active site
243230008019	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
243230008020	Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_1; cl12235
243230008021	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
243230008022	active site
243230008023	Int/Topo IB signature motif; other site
243230008024	catalytic residues [active]
243230008025	DNA binding site [nucleotide binding]
243230008026	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
243230008027	putative homodimer interface [polypeptide binding]; other site
243230008028	putative homotetramer interface [polypeptide binding]; other site
243230008029	putative allosteric switch controlling residues; other site
243230008030	putative metal binding site [ion binding]; other site
243230008031	putative homodimer-homodimer interface [polypeptide binding]; other site
243230008032	phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975
243230008033	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
243230008034	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243230008035	dimer interface [polypeptide binding]; other site
243230008036	conserved gate region; other site
243230008037	putative PBP binding loops; other site
243230008038	ABC-ATPase subunit interface; other site
243230008039	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
243230008040	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243230008041	dimer interface [polypeptide binding]; other site
243230008042	conserved gate region; other site
243230008043	putative PBP binding loops; other site
243230008044	ABC-ATPase subunit interface; other site
243230008045	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14272
243230008046	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
243230008047	Walker A/P-loop; other site
243230008048	ATP binding site [chemical binding]; other site
243230008049	Q-loop/lid; other site
243230008050	ABC transporter signature motif; other site
243230008051	Walker B; other site
243230008052	D-loop; other site
243230008053	H-loop/switch region; other site
243230008054	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
243230008055	PhoU domain; Region: PhoU; pfam01895
243230008056	PhoU domain; Region: PhoU; pfam01895
243230008057	Predicted transporter component [General function prediction only]; Region: COG2391
243230008058	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
243230008059	Sulphur transport; Region: Sulf_transp; pfam04143
243230008060	Predicted transporter component [General function prediction only]; Region: COG2391
243230008061	Sulphur transport; Region: Sulf_transp; pfam04143
243230008062	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
243230008063	catalytic residues [active]
243230008064	Domain of unknown function (DUF4132); Region: DUF4132; pfam13569
243230008065	Endonuclease V homolog [Replication, recombination, and repair]; Region: COG1628
243230008066	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
243230008067	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243230008068	dimer interface [polypeptide binding]; other site
243230008069	conserved gate region; other site
243230008070	putative PBP binding loops; other site
243230008071	ABC-ATPase subunit interface; other site
243230008072	molybdenum ABC transporter, periplasmic molybdate-binding protein; Region: modA; TIGR01256
243230008073	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
243230008074	dimer interface [polypeptide binding]; other site
243230008075	substrate binding site [chemical binding]; other site
243230008076	ATP binding site [chemical binding]; other site
243230008077	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
243230008078	ThiS interaction site; other site
243230008079	putative active site [active]
243230008080	tetramer interface [polypeptide binding]; other site
243230008081	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
243230008082	thiS-thiF/thiG interaction site; other site
243230008083	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
243230008084	thiamine phosphate binding site [chemical binding]; other site
243230008085	active site
243230008086	pyrophosphate binding site [ion binding]; other site
243230008087	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
243230008088	ThiC-associated domain; Region: ThiC-associated; pfam13667
243230008089	ThiC family; Region: ThiC; pfam01964
243230008090	Sulfate transporter family; Region: Sulfate_transp; cl19250
243230008091	xanthine permease; Region: pbuX; TIGR03173
243230008092	Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630
243230008093	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
243230008094	catalytic loop [active]
243230008095	iron binding site [ion binding]; other site
243230008096	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
243230008097	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
243230008098	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
243230008099	Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631
243230008100	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
243230008101	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
243230008102	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
243230008103	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
243230008104	XdhC Rossmann domain; Region: XdhC_C; pfam13478
243230008105	guanine deaminase; Provisional; Region: PRK09228
243230008106	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
243230008107	active site
243230008108	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
243230008109	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243230008110	metal binding site [ion binding]; metal-binding site
243230008111	active site
243230008112	I-site; other site
243230008113	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
243230008114	DNA binding site [nucleotide binding]
243230008115	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
243230008116	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
243230008117	dimer interface [polypeptide binding]; other site
243230008118	pyridoxal binding site [chemical binding]; other site
243230008119	ATP binding site [chemical binding]; other site
243230008120	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
243230008121	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483
243230008122	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243230008123	Zn2+ binding site [ion binding]; other site
243230008124	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
243230008125	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
243230008126	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243230008127	Walker A/P-loop; other site
243230008128	ATP binding site [chemical binding]; other site
243230008129	Q-loop/lid; other site
243230008130	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243230008131	ABC transporter signature motif; other site
243230008132	Walker B; other site
243230008133	D-loop; other site
243230008134	H-loop/switch region; other site
243230008135	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243230008136	Walker A/P-loop; other site
243230008137	ATP binding site [chemical binding]; other site
243230008138	Q-loop/lid; other site
243230008139	ABC transporter signature motif; other site
243230008140	Walker B; other site
243230008141	D-loop; other site
243230008142	H-loop/switch region; other site
243230008143	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
243230008144	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
243230008145	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243230008146	FeS/SAM binding site; other site
243230008147	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
243230008148	short chain dehydrogenase; Provisional; Region: PRK07109
243230008149	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
243230008150	catalytic core [active]
243230008151	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
243230008152	Phosphotransferase enzyme family; Region: APH; pfam01636
243230008153	putative active site [active]
243230008154	putative substrate binding site [chemical binding]; other site
243230008155	ATP binding site [chemical binding]; other site
243230008156	short chain dehydrogenase; Provisional; Region: PRK05650
243230008157	classical (c) SDRs; Region: SDR_c; cd05233
243230008158	NAD(P) binding site [chemical binding]; other site
243230008159	active site
243230008160	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
243230008161	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
243230008162	active site
243230008163	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
243230008164	CoenzymeA binding site [chemical binding]; other site
243230008165	subunit interaction site [polypeptide binding]; other site
243230008166	PHB binding site; other site
243230008167	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
243230008168	putative active site [active]
243230008169	putative catalytic site [active]
243230008170	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
243230008171	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243230008172	NAD(P) binding site [chemical binding]; other site
243230008173	active site
243230008174	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
243230008175	homodimer interface [polypeptide binding]; other site
243230008176	NAD binding pocket [chemical binding]; other site
243230008177	ATP binding pocket [chemical binding]; other site
243230008178	Mg binding site [ion binding]; other site
243230008179	active-site loop [active]
243230008180	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
243230008181	E-class dimer interface [polypeptide binding]; other site
243230008182	P-class dimer interface [polypeptide binding]; other site
243230008183	active site
243230008184	Cu2+ binding site [ion binding]; other site
243230008185	Zn2+ binding site [ion binding]; other site
243230008186	Uncharacterized conserved protein [Function unknown]; Region: COG3391
243230008187	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
243230008188	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645
243230008189	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
243230008190	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243230008191	active site
243230008192	phosphorylation site [posttranslational modification]
243230008193	intermolecular recognition site; other site
243230008194	dimerization interface [polypeptide binding]; other site
243230008195	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG5278
243230008196	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243230008197	dimerization interface [polypeptide binding]; other site
243230008198	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243230008199	dimer interface [polypeptide binding]; other site
243230008200	phosphorylation site [posttranslational modification]
243230008201	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243230008202	ATP binding site [chemical binding]; other site
243230008203	Mg2+ binding site [ion binding]; other site
243230008204	G-X-G motif; other site
243230008205	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
243230008206	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
243230008207	active site
243230008208	Zn binding site [ion binding]; other site
243230008209	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
243230008210	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
243230008211	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
243230008212	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243230008213	dimer interface [polypeptide binding]; other site
243230008214	conserved gate region; other site
243230008215	putative PBP binding loops; other site
243230008216	ABC-ATPase subunit interface; other site
243230008217	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
243230008218	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243230008219	dimer interface [polypeptide binding]; other site
243230008220	conserved gate region; other site
243230008221	putative PBP binding loops; other site
243230008222	ABC-ATPase subunit interface; other site
243230008223	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
243230008224	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
243230008225	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
243230008226	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
243230008227	DNA-binding site [nucleotide binding]; DNA binding site
243230008228	UTRA domain; Region: UTRA; pfam07702
243230008229	Predicted molecular chaperone distantly related to HSP70-fold metalloproteases [Posttranslational modification, protein turnover, chaperones]; Region: COG2377
243230008230	N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274
243230008231	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
243230008232	putative active site [active]
243230008233	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
243230008234	Beta-lactamase; Region: Beta-lactamase; pfam00144
243230008235	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
243230008236	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
243230008237	Beta-lactamase; Region: Beta-lactamase; pfam00144
243230008238	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
243230008239	NAD binding site [chemical binding]; other site
243230008240	catalytic residues [active]
243230008241	Protein involved in beta-1,3-glucan synthesis [Carbohydrate transport and metabolism]; Region: SMI1; COG4282
243230008242	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
243230008243	extended (e) SDRs; Region: SDR_e; cd08946
243230008244	NAD(P) binding site [chemical binding]; other site
243230008245	active site
243230008246	substrate binding site [chemical binding]; other site
243230008247	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309
243230008248	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
243230008249	3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295
243230008250	N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266
243230008251	tetramer interface [polypeptide binding]; other site
243230008252	C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256
243230008253	tetramer interface [polypeptide binding]; other site
243230008254	active site
243230008255	metal binding site [ion binding]; metal-binding site
243230008256	Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
243230008257	Moco binding site; other site
243230008258	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
243230008259	metal coordination site [ion binding]; other site
243230008260	dimerization interface [polypeptide binding]; other site
243230008261	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
243230008262	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
243230008263	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
243230008264	putative substrate binding pocket [chemical binding]; other site
243230008265	trimer interface [polypeptide binding]; other site
243230008266	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
243230008267	active site
243230008268	Domain of unknown function (DUF1990); Region: DUF1990; pfam09348
243230008269	Domain of unknown function (DUF1990); Region: DUF1990; cl01969
243230008270	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
243230008271	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
243230008272	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
243230008273	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
243230008274	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
243230008275	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
243230008276	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
243230008277	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
243230008278	catalytic loop [active]
243230008279	iron binding site [ion binding]; other site
243230008280	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
243230008281	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
243230008282	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
243230008283	catalytic loop [active]
243230008284	iron binding site [ion binding]; other site
243230008285	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
243230008286	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
243230008287	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
243230008288	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
243230008289	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
243230008290	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
243230008291	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
243230008292	Predicted oxidoreductase [General function prediction only]; Region: COG3573
243230008293	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
243230008294	Cobalamin-5-phosphate synthase [Coenzyme metabolism]; Region: CobS; COG0368
243230008295	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
243230008296	putative dimer interface [polypeptide binding]; other site
243230008297	active site pocket [active]
243230008298	putative cataytic base [active]
243230008299	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
243230008300	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
243230008301	Rrf2 family protein; Region: rrf2_super; TIGR00738
243230008302	Predicted transcriptional regulator [Transcription]; Region: COG1959
243230008303	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
243230008304	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
243230008305	heme-binding site [chemical binding]; other site
243230008306	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
243230008307	FAD binding pocket [chemical binding]; other site
243230008308	FAD binding motif [chemical binding]; other site
243230008309	phosphate binding motif [ion binding]; other site
243230008310	beta-alpha-beta structure motif; other site
243230008311	NAD binding pocket [chemical binding]; other site
243230008312	Heme binding  pocket [chemical binding]; other site
243230008313	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243230008314	Radical SAM superfamily; Region: Radical_SAM; pfam04055
243230008315	FeS/SAM binding site; other site
243230008316	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
243230008317	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
243230008318	peptide binding site [polypeptide binding]; other site
243230008319	Major Facilitator Superfamily; Region: MFS_1; pfam07690
243230008320	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243230008321	putative substrate translocation pore; other site
243230008322	Transcriptional regulators [Transcription]; Region: MarR; COG1846
243230008323	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
243230008324	dimerization interface [polypeptide binding]; other site
243230008325	putative DNA binding site [nucleotide binding]; other site
243230008326	putative Zn2+ binding site [ion binding]; other site
243230008327	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
243230008328	Leishmanolysin; Region: Peptidase_M8; cl19482
243230008329	active site
243230008330	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
243230008331	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
243230008332	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
243230008333	active site
243230008334	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
243230008335	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
243230008336	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
243230008337	NAD(P) binding site [chemical binding]; other site
243230008338	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
243230008339	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
243230008340	DNA binding residues [nucleotide binding]
243230008341	dimer interface [polypeptide binding]; other site
243230008342	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
243230008343	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
243230008344	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
243230008345	FMN binding site [chemical binding]; other site
243230008346	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
243230008347	Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936
243230008348	active site
243230008349	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
243230008350	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
243230008351	acyl-activating enzyme (AAE) consensus motif; other site
243230008352	AMP binding site [chemical binding]; other site
243230008353	active site
243230008354	CoA binding site [chemical binding]; other site
243230008355	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
243230008356	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
243230008357	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
243230008358	Ferritin-like domain; Region: Ferritin_2; pfam13668
243230008359	hydroperoxidase II; Provisional; Region: katE; PRK11249
243230008360	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
243230008361	tetramer interface [polypeptide binding]; other site
243230008362	heme binding pocket [chemical binding]; other site
243230008363	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
243230008364	domain interactions; other site
243230008365	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
243230008366	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
243230008367	Walker A/P-loop; other site
243230008368	ATP binding site [chemical binding]; other site
243230008369	Q-loop/lid; other site
243230008370	ABC transporter signature motif; other site
243230008371	Walker B; other site
243230008372	D-loop; other site
243230008373	H-loop/switch region; other site
243230008374	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
243230008375	TM-ABC transporter signature motif; other site
243230008376	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
243230008377	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
243230008378	Walker A/P-loop; other site
243230008379	ATP binding site [chemical binding]; other site
243230008380	Q-loop/lid; other site
243230008381	ABC transporter signature motif; other site
243230008382	Walker B; other site
243230008383	D-loop; other site
243230008384	H-loop/switch region; other site
243230008385	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
243230008386	TM-ABC transporter signature motif; other site
243230008387	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
243230008388	putative ligand binding site [chemical binding]; other site
243230008389	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314
243230008390	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
243230008391	acyl-activating enzyme (AAE) consensus motif; other site
243230008392	AMP binding site [chemical binding]; other site
243230008393	active site
243230008394	CoA binding site [chemical binding]; other site
243230008395	Protein of unknown function (DUF524); Region: DUF524; pfam04411
243230008396	GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401
243230008397	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243230008398	Walker A motif; other site
243230008399	ATP binding site [chemical binding]; other site
243230008400	Walker B motif; other site
243230008401	arginine finger; other site
243230008402	Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191
243230008403	FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663
243230008404	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258
243230008405	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
243230008406	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243230008407	ABC transporter signature motif; other site
243230008408	Walker B; other site
243230008409	D-loop; other site
243230008410	H-loop/switch region; other site
243230008411	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
243230008412	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
243230008413	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
243230008414	active site
243230008415	benzoate transport; Region: 2A0115; TIGR00895
243230008416	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243230008417	putative substrate translocation pore; other site
243230008418	putative nicotinate phosphoribosyltransferase; Region: NAPRTase_put; TIGR01513
243230008419	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
243230008420	active site
243230008421	bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379
243230008422	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional proteins, also containing a Nudix hydrolase domain; Region: NMNAT_Nudix; cd02168
243230008423	active site
243230008424	(T/H)XGH motif; other site
243230008425	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
243230008426	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
243230008427	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
243230008428	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
243230008429	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
243230008430	malate dehydrogenase; Provisional; Region: PRK13529
243230008431	Malic enzyme, N-terminal domain; Region: malic; pfam00390
243230008432	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
243230008433	NAD(P) binding site [chemical binding]; other site
243230008434	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
243230008435	active site
243230008436	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
243230008437	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
243230008438	FtsX-like permease family; Region: FtsX; pfam02687
243230008439	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243230008440	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
243230008441	Walker A/P-loop; other site
243230008442	ATP binding site [chemical binding]; other site
243230008443	Q-loop/lid; other site
243230008444	Peptidase S8 family domain in Fervidolysin; Region: Peptidases_S8_Fervidolysin_like; cd07485
243230008445	Subtilase family; Region: Peptidase_S8; pfam00082
243230008446	active site
243230008447	catalytic triad [active]
243230008448	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
243230008449	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
243230008450	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
243230008451	putative active site [active]
243230008452	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
243230008453	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
243230008454	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
243230008455	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
243230008456	active site
243230008457	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
243230008458	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243230008459	binding surface
243230008460	TPR motif; other site
243230008461	Tetratricopeptide repeat; Region: TPR_12; pfam13424
243230008462	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243230008463	TPR motif; other site
243230008464	binding surface
243230008465	Tetratricopeptide repeat; Region: TPR_12; pfam13424
243230008466	FtsH Extracellular; Region: FtsH_ext; pfam06480
243230008467	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
243230008468	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243230008469	Walker A motif; other site
243230008470	ATP binding site [chemical binding]; other site
243230008471	Walker B motif; other site
243230008472	arginine finger; other site
243230008473	Peptidase family M41; Region: Peptidase_M41; pfam01434
243230008474	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
243230008475	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
243230008476	MG2 domain; Region: A2M_N; pfam01835
243230008477	Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703
243230008478	Alpha-2-macroglobulin family; Region: A2M; pfam00207
243230008479	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
243230008480	Tetratricopeptide repeat; Region: TPR_12; pfam13424
243230008481	Tetratricopeptide repeat; Region: TPR_12; pfam13424
243230008482	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243230008483	metal binding site [ion binding]; metal-binding site
243230008484	active site
243230008485	I-site; other site
243230008486	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
243230008487	Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372
243230008488	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
243230008489	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
243230008490	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
243230008491	AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052
243230008492	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
243230008493	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
243230008494	active site residue [active]
243230008495	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243230008496	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
243230008497	acyl-CoA synthetase; Validated; Region: PRK06178
243230008498	Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935
243230008499	acyl-activating enzyme (AAE) consensus motif; other site
243230008500	putative AMP binding site [chemical binding]; other site
243230008501	putative active site [active]
243230008502	putative CoA binding site [chemical binding]; other site
243230008503	Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439
243230008504	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
243230008505	ATP-grasp domain; Region: ATP-grasp_4; cl17255
243230008506	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
243230008507	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
243230008508	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
243230008509	carboxyltransferase (CT) interaction site; other site
243230008510	biotinylation site [posttranslational modification]; other site
243230008511	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
243230008512	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
243230008513	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172
243230008514	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
243230008515	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
243230008516	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
243230008517	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
243230008518	Switch II region; other site
243230008519	G4 box; other site
243230008520	G5 box; other site
243230008521	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
243230008522	Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371
243230008523	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
243230008524	dimer interface [polypeptide binding]; other site
243230008525	catalytic residues [active]
243230008526	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
243230008527	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
243230008528	Hydrogenase/urease accessory protein [Posttranslational modification, protein turnover, chaperones]; Region: HupE; COG2370
243230008529	urease subunit alpha; Reviewed; Region: ureC; PRK13207
243230008530	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
243230008531	subunit interactions [polypeptide binding]; other site
243230008532	active site
243230008533	flap region; other site
243230008534	bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192
243230008535	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
243230008536	alpha-gamma subunit interface [polypeptide binding]; other site
243230008537	beta-gamma subunit interface [polypeptide binding]; other site
243230008538	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
243230008539	alpha-beta subunit interface [polypeptide binding]; other site
243230008540	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
243230008541	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
243230008542	putative ligand binding site [chemical binding]; other site
243230008543	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
243230008544	TM-ABC transporter signature motif; other site
243230008545	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
243230008546	TM-ABC transporter signature motif; other site
243230008547	Uncharacterized ABC-type transport system, ATPase component [General function prediction only]; Region: COG4674
243230008548	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
243230008549	Walker A/P-loop; other site
243230008550	ATP binding site [chemical binding]; other site
243230008551	Q-loop/lid; other site
243230008552	ABC transporter signature motif; other site
243230008553	Walker B; other site
243230008554	D-loop; other site
243230008555	H-loop/switch region; other site
243230008556	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
243230008557	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
243230008558	Walker A/P-loop; other site
243230008559	ATP binding site [chemical binding]; other site
243230008560	Q-loop/lid; other site
243230008561	ABC transporter signature motif; other site
243230008562	Walker B; other site
243230008563	D-loop; other site
243230008564	H-loop/switch region; other site
243230008565	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538
243230008566	PA/protease or protease-like domain interface [polypeptide binding]; other site
243230008567	Peptide-N-glycosidase F, N terminal; Region: N-glycanase_N; pfam09112
243230008568	Peptide-N-glycosidase F, C terminal; Region: N-glycanase_C; pfam09113
243230008569	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
243230008570	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
243230008571	malonyl-CoA binding site [chemical binding]; other site
243230008572	dimer interface [polypeptide binding]; other site
243230008573	active site
243230008574	product binding site; other site
243230008575	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227
243230008576	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243230008577	S-adenosylmethionine binding site [chemical binding]; other site
243230008578	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
243230008579	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
243230008580	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
243230008581	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
243230008582	homodimer interface [polypeptide binding]; other site
243230008583	active site
243230008584	TDP-binding site; other site
243230008585	acceptor substrate-binding pocket; other site
243230008586	Catalytic domain, repeat 1, of phospholipase D from Streptomyces Sp. Strain PMF and similar proteins; Region: PLDc_PMFPLD_like_1; cd09108
243230008587	domain interface [polypeptide binding]; other site
243230008588	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
243230008589	putative active site [active]
243230008590	catalytic site [active]
243230008591	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
243230008592	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
243230008593	metal ion-dependent adhesion site (MIDAS); other site
243230008594	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
243230008595	Double zinc ribbon; Region: DZR; pfam12773
243230008596	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
243230008597	Catalytic domain of Protein Kinases; Region: PKc; cd00180
243230008598	active site
243230008599	ATP binding site [chemical binding]; other site
243230008600	substrate binding site [chemical binding]; other site
243230008601	activation loop (A-loop); other site
243230008602	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
243230008603	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
243230008604	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
243230008605	phosphopeptide binding site; other site
243230008606	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
243230008607	active site
243230008608	Protein kinase domain; Region: Pkinase; pfam00069
243230008609	Catalytic domain of Protein Kinases; Region: PKc; cd00180
243230008610	active site
243230008611	ATP binding site [chemical binding]; other site
243230008612	substrate binding site [chemical binding]; other site
243230008613	activation loop (A-loop); other site
243230008614	Bacterial SH3 domain; Region: SH3_3; pfam08239
243230008615	Right handed beta helix region; Region: Beta_helix; pfam13229
243230008616	Right handed beta helix region; Region: Beta_helix; pfam13229
243230008617	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
243230008618	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243230008619	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
243230008620	putative dimerization interface [polypeptide binding]; other site
243230008621	putative substrate binding pocket [chemical binding]; other site
243230008622	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
243230008623	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
243230008624	active site
243230008625	Kynureninase [Amino acid transport and metabolism]; Region: COG3844
243230008626	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
243230008627	catalytic residue [active]
243230008628	Tryptophan 2,3-dioxygenase (vermilion) [Amino acid transport and metabolism]; Region: TDO2; COG3483
243230008629	Protein of unknown function (DUF2974); Region: DUF2974; pfam11187
243230008630	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
243230008631	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
243230008632	active site
243230008633	catalytic residues [active]
243230008634	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243230008635	Tetratricopeptide repeat; Region: TPR_12; pfam13424
243230008636	binding surface
243230008637	TPR motif; other site
243230008638	Tetratricopeptide repeat; Region: TPR_12; pfam13424
243230008639	Tetratricopeptide repeat; Region: TPR_12; pfam13424
243230008640	Tetratricopeptide repeat; Region: TPR_12; pfam13424
243230008641	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
243230008642	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243230008643	Zn2+ binding site [ion binding]; other site
243230008644	Mg2+ binding site [ion binding]; other site
243230008645	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243230008646	metal binding site [ion binding]; metal-binding site
243230008647	active site
243230008648	I-site; other site
243230008649	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
243230008650	NAD(P) binding site [chemical binding]; other site
243230008651	catalytic residues [active]
243230008652	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
243230008653	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
243230008654	dimerization interface [polypeptide binding]; other site
243230008655	putative DNA binding site [nucleotide binding]; other site
243230008656	putative Zn2+ binding site [ion binding]; other site
243230008657	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
243230008658	Catalytic site [active]
243230008659	Erythromycin esterase homolog [General function prediction only]; Region: COG2312
243230008660	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
243230008661	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
243230008662	NAD(P) binding site [chemical binding]; other site
243230008663	catalytic residues [active]
243230008664	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
243230008665	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
243230008666	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
243230008667	Walker A/P-loop; other site
243230008668	ATP binding site [chemical binding]; other site
243230008669	Q-loop/lid; other site
243230008670	ABC transporter signature motif; other site
243230008671	Walker B; other site
243230008672	D-loop; other site
243230008673	H-loop/switch region; other site
243230008674	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243230008675	active site
243230008676	phosphorylation site [posttranslational modification]
243230008677	intermolecular recognition site; other site
243230008678	dimerization interface [polypeptide binding]; other site
243230008679	CheW-like domain; Region: CheW; pfam01584
243230008680	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243230008681	dimerization interface [polypeptide binding]; other site
243230008682	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243230008683	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
243230008684	dimer interface [polypeptide binding]; other site
243230008685	putative CheW interface [polypeptide binding]; other site
243230008686	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243230008687	dimerization interface [polypeptide binding]; other site
243230008688	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243230008689	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
243230008690	dimer interface [polypeptide binding]; other site
243230008691	putative CheW interface [polypeptide binding]; other site
243230008692	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243230008693	dimerization interface [polypeptide binding]; other site
243230008694	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243230008695	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
243230008696	dimer interface [polypeptide binding]; other site
243230008697	putative CheW interface [polypeptide binding]; other site
243230008698	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
243230008699	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
243230008700	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243230008701	ATP binding site [chemical binding]; other site
243230008702	Mg2+ binding site [ion binding]; other site
243230008703	G-X-G motif; other site
243230008704	CheW-like domain; Region: CheW; pfam01584
243230008705	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
243230008706	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243230008707	active site
243230008708	phosphorylation site [posttranslational modification]
243230008709	intermolecular recognition site; other site
243230008710	dimerization interface [polypeptide binding]; other site
243230008711	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078
243230008712	phosphorylation site [posttranslational modification]
243230008713	intermolecular recognition site; other site
243230008714	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
243230008715	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243230008716	active site
243230008717	phosphorylation site [posttranslational modification]
243230008718	intermolecular recognition site; other site
243230008719	dimerization interface [polypeptide binding]; other site
243230008720	Roadblock/LC7 domain; Region: Robl_LC7; smart00960
243230008721	Uncharacterized conserved protein [Function unknown]; Region: COG4850
243230008722	threonine synthase; Validated; Region: PRK09225
243230008723	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
243230008724	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243230008725	catalytic residue [active]
243230008726	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
243230008727	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
243230008728	oligomer interface [polypeptide binding]; other site
243230008729	metal binding site [ion binding]; metal-binding site
243230008730	metal binding site [ion binding]; metal-binding site
243230008731	putative Cl binding site [ion binding]; other site
243230008732	aspartate ring; other site
243230008733	basic sphincter; other site
243230008734	hydrophobic gate; other site
243230008735	periplasmic entrance; other site
243230008736	Predicted membrane protein [Function unknown]; Region: COG4420
243230008737	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
243230008738	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
243230008739	oxidoreductase; Provisional; Region: PRK06128
243230008740	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
243230008741	NAD binding site [chemical binding]; other site
243230008742	metal binding site [ion binding]; metal-binding site
243230008743	active site
243230008744	FRG domain; Region: FRG; pfam08867
243230008745	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
243230008746	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
243230008747	UDP-galactopyranose mutase; Region: GLF; pfam03275
243230008748	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
243230008749	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
243230008750	putative homodimer interface [polypeptide binding]; other site
243230008751	Plasmid replication initiator protein [DNA replication, recombination, and repair]; Region: COG5534