-- dump date   	20140619_061411
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
880072000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
880072000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
880072000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072000004	Walker A motif; other site
880072000005	ATP binding site [chemical binding]; other site
880072000006	Walker B motif; other site
880072000007	arginine finger; other site
880072000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
880072000009	DnaA box-binding interface [nucleotide binding]; other site
880072000010	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
880072000011	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
880072000012	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
880072000013	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
880072000014	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
880072000015	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
880072000016	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
880072000017	Nitrogen regulatory protein P-II; Region: P-II; smart00938
880072000018	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
880072000019	thymidylate kinase; Validated; Region: tmk; PRK00698
880072000020	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
880072000021	TMP-binding site; other site
880072000022	ATP-binding site [chemical binding]; other site
880072000023	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
880072000024	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
880072000025	putative dimer interface [polypeptide binding]; other site
880072000026	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
880072000027	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
880072000028	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
880072000029	dihydroorotase; Validated; Region: pyrC; PRK09357
880072000030	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
880072000031	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
880072000032	active site
880072000033	AAA ATPase domain; Region: AAA_16; pfam13191
880072000034	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
880072000035	Uncharacterized conserved protein [Function unknown]; Region: COG2006
880072000036	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
880072000037	dimer interface [polypeptide binding]; other site
880072000038	putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054
880072000039	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
880072000040	FeS/SAM binding site; other site
880072000041	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
880072000042	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
880072000043	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072000044	Walker A motif; other site
880072000045	ATP binding site [chemical binding]; other site
880072000046	Walker B motif; other site
880072000047	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
880072000048	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
880072000049	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
880072000050	HflX GTPase family; Region: HflX; cd01878
880072000051	G1 box; other site
880072000052	GTP/Mg2+ binding site [chemical binding]; other site
880072000053	Switch I region; other site
880072000054	G2 box; other site
880072000055	G3 box; other site
880072000056	Switch II region; other site
880072000057	G4 box; other site
880072000058	G5 box; other site
880072000059	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
880072000060	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
880072000061	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072000062	S-adenosylmethionine binding site [chemical binding]; other site
880072000063	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
880072000064	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
880072000065	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072000066	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
880072000067	Walker A motif; other site
880072000068	ATP binding site [chemical binding]; other site
880072000069	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
880072000070	Response regulator receiver domain; Region: Response_reg; pfam00072
880072000071	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072000072	active site
880072000073	phosphorylation site [posttranslational modification]
880072000074	intermolecular recognition site; other site
880072000075	dimerization interface [polypeptide binding]; other site
880072000076	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
880072000077	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072000078	Uncharacterized conserved protein [Function unknown]; Region: COG4198
880072000079	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
880072000080	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
880072000081	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
880072000082	pyridoxal 5'-phosphate binding site [chemical binding]; other site
880072000083	homodimer interface [polypeptide binding]; other site
880072000084	catalytic residue [active]
880072000085	cytidylate kinase; Provisional; Region: cmk; PRK00023
880072000086	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
880072000087	CMP-binding site; other site
880072000088	The sites determining sugar specificity; other site
880072000089	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
880072000090	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
880072000091	RNA binding site [nucleotide binding]; other site
880072000092	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
880072000093	RNA binding site [nucleotide binding]; other site
880072000094	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
880072000095	RNA binding site [nucleotide binding]; other site
880072000096	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
880072000097	RNA binding site [nucleotide binding]; other site
880072000098	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
880072000099	RNA binding site [nucleotide binding]; other site
880072000100	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
880072000101	RNA binding site [nucleotide binding]; other site
880072000102	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
880072000103	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
880072000104	tandem repeat interface [polypeptide binding]; other site
880072000105	oligomer interface [polypeptide binding]; other site
880072000106	active site residues [active]
880072000107	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
880072000108	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
880072000109	Peptidase family M23; Region: Peptidase_M23; pfam01551
880072000110	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
880072000111	FAD binding domain; Region: FAD_binding_4; pfam01565
880072000112	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
880072000113	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
880072000114	endonuclease III; Region: ENDO3c; smart00478
880072000115	minor groove reading motif; other site
880072000116	helix-hairpin-helix signature motif; other site
880072000117	substrate binding pocket [chemical binding]; other site
880072000118	active site
880072000119	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
880072000120	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
880072000121	Walker A/P-loop; other site
880072000122	ATP binding site [chemical binding]; other site
880072000123	Q-loop/lid; other site
880072000124	ABC transporter signature motif; other site
880072000125	Walker B; other site
880072000126	D-loop; other site
880072000127	H-loop/switch region; other site
880072000128	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
880072000129	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
880072000130	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
880072000131	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
880072000132	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
880072000133	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
880072000134	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
880072000135	FAD binding site [chemical binding]; other site
880072000136	Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225
880072000137	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
880072000138	malate dehydrogenase; Reviewed; Region: PRK06223
880072000139	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
880072000140	NAD(P) binding site [chemical binding]; other site
880072000141	dimer interface [polypeptide binding]; other site
880072000142	tetramer (dimer of dimers) interface [polypeptide binding]; other site
880072000143	substrate binding site [chemical binding]; other site
880072000144	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
880072000145	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
880072000146	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
880072000147	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
880072000148	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
880072000149	Catalytic site; other site
880072000150	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
880072000151	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
880072000152	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
880072000153	NAD binding site [chemical binding]; other site
880072000154	putative substrate binding site 2 [chemical binding]; other site
880072000155	putative substrate binding site 1 [chemical binding]; other site
880072000156	active site
880072000157	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
880072000158	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
880072000159	non-specific DNA binding site [nucleotide binding]; other site
880072000160	salt bridge; other site
880072000161	sequence-specific DNA binding site [nucleotide binding]; other site
880072000162	Dynamin family; Region: Dynamin_N; pfam00350
880072000163	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
880072000164	Helix-turn-helix domain; Region: HTH_38; pfam13936
880072000165	DNA-binding interface [nucleotide binding]; DNA binding site
880072000166	Integrase core domain; Region: rve; pfam00665
880072000167	transposase; Provisional; Region: PRK06526
880072000168	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072000169	Walker A motif; other site
880072000170	ATP binding site [chemical binding]; other site
880072000171	Walker B motif; other site
880072000172	multiple promoter invertase; Provisional; Region: mpi; PRK13413
880072000173	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
880072000174	catalytic residues [active]
880072000175	catalytic nucleophile [active]
880072000176	Presynaptic Site I dimer interface [polypeptide binding]; other site
880072000177	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
880072000178	Synaptic Flat tetramer interface [polypeptide binding]; other site
880072000179	Synaptic Site I dimer interface [polypeptide binding]; other site
880072000180	DNA binding site [nucleotide binding]
880072000181	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
880072000182	Walker A/P-loop; other site
880072000183	ATP binding site [chemical binding]; other site
880072000184	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
880072000185	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
880072000186	putative active site [active]
880072000187	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
880072000188	PIN domain; Region: PIN_3; cl17397
880072000189	PIN domain; Region: PIN_3; pfam13470
880072000190	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
880072000191	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
880072000192	IHF dimer interface [polypeptide binding]; other site
880072000193	IHF - DNA interface [nucleotide binding]; other site
880072000194	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
880072000195	DEAD-like helicases superfamily; Region: DEXDc; smart00487
880072000196	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
880072000197	ATP binding site [chemical binding]; other site
880072000198	putative Mg++ binding site [ion binding]; other site
880072000199	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
880072000200	nucleotide binding region [chemical binding]; other site
880072000201	ATP-binding site [chemical binding]; other site
880072000202	Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710
880072000203	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
880072000204	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
880072000205	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
880072000206	N-terminal plug; other site
880072000207	ligand-binding site [chemical binding]; other site
880072000208	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
880072000209	Uncharacterized subfamily of S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase_like; cd11724
880072000210	Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798
880072000211	putative SAM binding site [chemical binding]; other site
880072000212	putative homodimer interface [polypeptide binding]; other site
880072000213	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
880072000214	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
880072000215	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
880072000216	Putative Fe-S cluster; Region: FeS; cl17515
880072000217	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
880072000218	Low molecular weight phosphatase family; Region: LMWPc; cd00115
880072000219	active site
880072000220	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
880072000221	Low molecular weight phosphatase family; Region: LMWPc; cl00105
880072000222	active site
880072000223	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
880072000224	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
880072000225	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
880072000226	Predicted permease; Region: DUF318; cl17795
880072000227	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
880072000228	HsdM N-terminal domain; Region: HsdM_N; pfam12161
880072000229	Methyltransferase domain; Region: Methyltransf_26; pfam13659
880072000230	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
880072000231	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
880072000232	Uncharacterized conserved protein [Function unknown]; Region: COG1479
880072000233	Protein of unknown function DUF262; Region: DUF262; pfam03235
880072000234	Uncharacterized conserved protein [Function unknown]; Region: COG3472
880072000235	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
880072000236	HsdM N-terminal domain; Region: HsdM_N; pfam12161
880072000237	Methyltransferase domain; Region: Methyltransf_26; pfam13659
880072000238	Transposase [DNA replication, recombination, and repair]; Region: COG5421
880072000239	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
880072000240	Helix-turn-helix domain; Region: HTH_38; pfam13936
880072000241	DNA-binding interface [nucleotide binding]; DNA binding site
880072000242	Integrase core domain; Region: rve; pfam00665
880072000243	transposase; Provisional; Region: PRK06526
880072000244	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072000245	Walker A motif; other site
880072000246	ATP binding site [chemical binding]; other site
880072000247	Walker B motif; other site
880072000248	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637
880072000249	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693
880072000250	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
880072000251	CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875
880072000252	CRISPR-associated negative auto-regulator DevR/Csa2; Region: DevR; pfam01905
880072000253	CRISPR/Cas system-associated protein Csa5; Region: Csa5_I-A; cl09906
880072000254	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
880072000255	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
880072000256	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
880072000257	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
880072000258	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
880072000259	Response regulator receiver domain; Region: Response_reg; pfam00072
880072000260	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072000261	active site
880072000262	phosphorylation site [posttranslational modification]
880072000263	intermolecular recognition site; other site
880072000264	dimerization interface [polypeptide binding]; other site
880072000265	cyclase homology domain; Region: CHD; cd07302
880072000266	nucleotidyl binding site; other site
880072000267	metal binding site [ion binding]; metal-binding site
880072000268	dimer interface [polypeptide binding]; other site
880072000269	PAS fold; Region: PAS_3; pfam08447
880072000270	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072000271	putative active site [active]
880072000272	heme pocket [chemical binding]; other site
880072000273	PAS domain S-box; Region: sensory_box; TIGR00229
880072000274	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072000275	putative active site [active]
880072000276	heme pocket [chemical binding]; other site
880072000277	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
880072000278	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
880072000279	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
880072000280	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072000281	dimer interface [polypeptide binding]; other site
880072000282	phosphorylation site [posttranslational modification]
880072000283	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072000284	ATP binding site [chemical binding]; other site
880072000285	Mg2+ binding site [ion binding]; other site
880072000286	G-X-G motif; other site
880072000287	Response regulator receiver domain; Region: Response_reg; pfam00072
880072000288	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072000289	active site
880072000290	phosphorylation site [posttranslational modification]
880072000291	intermolecular recognition site; other site
880072000292	dimerization interface [polypeptide binding]; other site
880072000293	Response regulator receiver domain; Region: Response_reg; pfam00072
880072000294	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072000295	active site
880072000296	phosphorylation site [posttranslational modification]
880072000297	intermolecular recognition site; other site
880072000298	dimerization interface [polypeptide binding]; other site
880072000299	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
880072000300	putative binding surface; other site
880072000301	active site
880072000302	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
880072000303	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
880072000304	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
880072000305	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
880072000306	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
880072000307	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
880072000308	active site
880072000309	Substrate binding site; other site
880072000310	Mg++ binding site; other site
880072000311	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
880072000312	putative trimer interface [polypeptide binding]; other site
880072000313	putative CoA binding site [chemical binding]; other site
880072000314	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
880072000315	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
880072000316	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
880072000317	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
880072000318	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
880072000319	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
880072000320	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
880072000321	Autotransporter beta-domain; Region: Autotransporter; smart00869
880072000322	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
880072000323	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
880072000324	putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055
880072000325	FeS/SAM binding site; other site
880072000326	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
880072000327	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
880072000328	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
880072000329	FeS/SAM binding site; other site
880072000330	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
880072000331	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
880072000332	H+ Antiporter protein; Region: 2A0121; TIGR00900
880072000333	putative substrate translocation pore; other site
880072000334	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072000335	S-adenosylmethionine binding site [chemical binding]; other site
880072000336	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
880072000337	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
880072000338	N-terminal plug; other site
880072000339	ligand-binding site [chemical binding]; other site
880072000340	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
880072000341	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
880072000342	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
880072000343	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
880072000344	dimer interface [polypeptide binding]; other site
880072000345	conserved gate region; other site
880072000346	putative PBP binding loops; other site
880072000347	ABC-ATPase subunit interface; other site
880072000348	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
880072000349	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
880072000350	dimer interface [polypeptide binding]; other site
880072000351	conserved gate region; other site
880072000352	putative PBP binding loops; other site
880072000353	ABC-ATPase subunit interface; other site
880072000354	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
880072000355	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
880072000356	Walker A/P-loop; other site
880072000357	ATP binding site [chemical binding]; other site
880072000358	Q-loop/lid; other site
880072000359	ABC transporter signature motif; other site
880072000360	Walker B; other site
880072000361	D-loop; other site
880072000362	H-loop/switch region; other site
880072000363	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
880072000364	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
880072000365	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
880072000366	Walker A/P-loop; other site
880072000367	ATP binding site [chemical binding]; other site
880072000368	Q-loop/lid; other site
880072000369	ABC transporter signature motif; other site
880072000370	Walker B; other site
880072000371	D-loop; other site
880072000372	H-loop/switch region; other site
880072000373	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
880072000374	dimer interface [polypeptide binding]; other site
880072000375	Alkaline phosphatase homologues; Region: alkPPc; smart00098
880072000376	active site
880072000377	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
880072000378	coproporphyrinogen III oxidase; Validated; Region: PRK05628
880072000379	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
880072000380	FeS/SAM binding site; other site
880072000381	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
880072000382	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
880072000383	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
880072000384	catalytic residues [active]
880072000385	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
880072000386	Permease; Region: Permease; pfam02405
880072000387	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
880072000388	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
880072000389	PUCC protein; Region: PUCC; pfam03209
880072000390	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
880072000391	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
880072000392	putative ADP-binding pocket [chemical binding]; other site
880072000393	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
880072000394	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
880072000395	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
880072000396	oligomer interface [polypeptide binding]; other site
880072000397	putative active site [active]
880072000398	metal binding site [ion binding]; metal-binding site
880072000399	EamA-like transporter family; Region: EamA; cl17759
880072000400	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
880072000401	substrate binding site [chemical binding]; other site
880072000402	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
880072000403	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
880072000404	23S rRNA interface [nucleotide binding]; other site
880072000405	L3 interface [polypeptide binding]; other site
880072000406	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
880072000407	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
880072000408	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
880072000409	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
880072000410	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
880072000411	dimerization interface 3.5A [polypeptide binding]; other site
880072000412	active site
880072000413	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
880072000414	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
880072000415	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072000416	putative active site [active]
880072000417	heme pocket [chemical binding]; other site
880072000418	PAS domain S-box; Region: sensory_box; TIGR00229
880072000419	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072000420	putative active site [active]
880072000421	heme pocket [chemical binding]; other site
880072000422	PAS domain S-box; Region: sensory_box; TIGR00229
880072000423	PAS domain; Region: PAS_8; pfam13188
880072000424	putative active site [active]
880072000425	heme pocket [chemical binding]; other site
880072000426	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072000427	PAS fold; Region: PAS_3; pfam08447
880072000428	putative active site [active]
880072000429	heme pocket [chemical binding]; other site
880072000430	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072000431	dimer interface [polypeptide binding]; other site
880072000432	phosphorylation site [posttranslational modification]
880072000433	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072000434	ATP binding site [chemical binding]; other site
880072000435	Mg2+ binding site [ion binding]; other site
880072000436	G-X-G motif; other site
880072000437	Response regulator receiver domain; Region: Response_reg; pfam00072
880072000438	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072000439	active site
880072000440	phosphorylation site [posttranslational modification]
880072000441	intermolecular recognition site; other site
880072000442	dimerization interface [polypeptide binding]; other site
880072000443	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
880072000444	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
880072000445	intersubunit interface [polypeptide binding]; other site
880072000446	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
880072000447	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
880072000448	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
880072000449	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
880072000450	ABC-ATPase subunit  interface; other site
880072000451	dimer interface [polypeptide binding]; other site
880072000452	putative PBP binding regions; other site
880072000453	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
880072000454	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
880072000455	non-specific DNA binding site [nucleotide binding]; other site
880072000456	salt bridge; other site
880072000457	sequence-specific DNA binding site [nucleotide binding]; other site
880072000458	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
880072000459	EF-hand domain pair; Region: EF_hand_5; pfam13499
880072000460	Ca2+ binding site [ion binding]; other site
880072000461	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
880072000462	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
880072000463	FAD binding pocket [chemical binding]; other site
880072000464	FAD binding motif [chemical binding]; other site
880072000465	phosphate binding motif [ion binding]; other site
880072000466	beta-alpha-beta structure motif; other site
880072000467	NAD binding pocket [chemical binding]; other site
880072000468	Iron coordination center [ion binding]; other site
880072000469	putative oxidoreductase; Provisional; Region: PRK12831
880072000470	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
880072000471	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
880072000472	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
880072000473	TIGR04076 family protein; Region: TIGR04076
880072000474	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
880072000475	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
880072000476	HSP70 interaction site [polypeptide binding]; other site
880072000477	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
880072000478	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
880072000479	dimer interface [polypeptide binding]; other site
880072000480	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
880072000481	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
880072000482	DNA binding residues [nucleotide binding]
880072000483	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
880072000484	Competence protein; Region: Competence; pfam03772
880072000485	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723
880072000486	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
880072000487	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
880072000488	Ligand binding site; other site
880072000489	Putative Catalytic site; other site
880072000490	DXD motif; other site
880072000491	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
880072000492	Cation efflux family; Region: Cation_efflux; pfam01545
880072000493	Formyltetrahydrofolate synthetase [Nucleotide transport and metabolism]; Region: MIS1; COG2759
880072000494	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
880072000495	Potassium binding sites [ion binding]; other site
880072000496	Cesium cation binding sites [ion binding]; other site
880072000497	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
880072000498	4Fe-4S binding domain; Region: Fer4; pfam00037
880072000499	Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915
880072000500	ACS interaction site; other site
880072000501	CODH interaction site; other site
880072000502	Prismane/CO dehydrogenase family; Region: Prismane; pfam03063
880072000503	cubane metal cluster (B-cluster) [ion binding]; other site
880072000504	Ni-Fe-S cluster (C-cluster) [ion binding]; other site
880072000505	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
880072000506	catalytic loop [active]
880072000507	iron binding site [ion binding]; other site
880072000508	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
880072000509	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
880072000510	catalytic residues [active]
880072000511	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
880072000512	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
880072000513	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
880072000514	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
880072000515	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
880072000516	binding surface
880072000517	TPR motif; other site
880072000518	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
880072000519	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
880072000520	Beta-lactamase; Region: Beta-lactamase; pfam00144
880072000521	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
880072000522	DNA polymerase I; Provisional; Region: PRK05755
880072000523	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
880072000524	active site
880072000525	metal binding site 1 [ion binding]; metal-binding site
880072000526	putative 5' ssDNA interaction site; other site
880072000527	metal binding site 3; metal-binding site
880072000528	metal binding site 2 [ion binding]; metal-binding site
880072000529	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
880072000530	putative DNA binding site [nucleotide binding]; other site
880072000531	putative metal binding site [ion binding]; other site
880072000532	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
880072000533	active site
880072000534	substrate binding site [chemical binding]; other site
880072000535	catalytic site [active]
880072000536	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
880072000537	active site
880072000538	DNA binding site [nucleotide binding]
880072000539	catalytic site [active]
880072000540	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
880072000541	FecR protein; Region: FecR; pfam04773
880072000542	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072000543	TPR motif; other site
880072000544	binding surface
880072000545	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072000546	TPR motif; other site
880072000547	binding surface
880072000548	TPR repeat; Region: TPR_11; pfam13414
880072000549	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072000550	binding surface
880072000551	TPR motif; other site
880072000552	Tetratricopeptide repeat; Region: TPR_16; pfam13432
880072000553	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
880072000554	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
880072000555	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
880072000556	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
880072000557	GDP-binding site [chemical binding]; other site
880072000558	ACT binding site; other site
880072000559	IMP binding site; other site
880072000560	phosphomethylpyrimidine kinase; Provisional; Region: PRK08573
880072000561	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
880072000562	dimer interface [polypeptide binding]; other site
880072000563	substrate binding site [chemical binding]; other site
880072000564	ATP binding site [chemical binding]; other site
880072000565	Uncharacterized conserved protein [Function unknown]; Region: COG1992
880072000566	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
880072000567	protein binding site [polypeptide binding]; other site
880072000568	Peptidase family M48; Region: Peptidase_M48; cl12018
880072000569	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072000570	binding surface
880072000571	TPR motif; other site
880072000572	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072000573	TPR motif; other site
880072000574	binding surface
880072000575	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
880072000576	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
880072000577	DXD motif; other site
880072000578	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
880072000579	Sporulation related domain; Region: SPOR; cl10051
880072000580	4Fe-4S binding domain; Region: Fer4_5; pfam12801
880072000581	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
880072000582	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
880072000583	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
880072000584	4Fe-4S binding domain; Region: Fer4; pfam00037
880072000585	Uncharacterized conserved protein [Function unknown]; Region: COG2006
880072000586	Domain of unknown function (DUF362); Region: DUF362; pfam04015
880072000587	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
880072000588	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
880072000589	FeS/SAM binding site; other site
880072000590	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
880072000591	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
880072000592	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
880072000593	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
880072000594	non-specific DNA binding site [nucleotide binding]; other site
880072000595	salt bridge; other site
880072000596	sequence-specific DNA binding site [nucleotide binding]; other site
880072000597	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
880072000598	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
880072000599	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
880072000600	active site
880072000601	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
880072000602	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
880072000603	Methyltransferase domain; Region: Methyltransf_24; pfam13578
880072000604	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986
880072000605	putative acyl-acceptor binding pocket; other site
880072000606	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
880072000607	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
880072000608	Heavy-metal-associated domain; Region: HMA; pfam00403
880072000609	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
880072000610	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
880072000611	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
880072000612	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
880072000613	Soluble P-type ATPase [General function prediction only]; Region: COG4087
880072000614	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
880072000615	S-adenosylmethionine synthetase; Provisional; Region: PRK12459
880072000616	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
880072000617	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
880072000618	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
880072000619	Protein of unknown function (DUF3419); Region: DUF3419; pfam11899
880072000620	Methyltransferase domain; Region: Methyltransf_31; pfam13847
880072000621	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072000622	S-adenosylmethionine binding site [chemical binding]; other site
880072000623	Nif-specific regulatory protein; Region: nifA; TIGR01817
880072000624	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
880072000625	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072000626	Walker A motif; other site
880072000627	ATP binding site [chemical binding]; other site
880072000628	Walker B motif; other site
880072000629	arginine finger; other site
880072000630	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
880072000631	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
880072000632	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
880072000633	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
880072000634	Peptidase family M23; Region: Peptidase_M23; pfam01551
880072000635	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
880072000636	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
880072000637	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
880072000638	active site
880072000639	catalytic site [active]
880072000640	N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797
880072000641	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
880072000642	active site
880072000643	catalytic site [active]
880072000644	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
880072000645	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
880072000646	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
880072000647	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
880072000648	catalytic site [active]
880072000649	active site
880072000650	TPR repeat; Region: TPR_11; pfam13414
880072000651	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072000652	binding surface
880072000653	TPR motif; other site
880072000654	CHASE2 domain; Region: CHASE2; pfam05226
880072000655	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
880072000656	cyclase homology domain; Region: CHD; cd07302
880072000657	nucleotidyl binding site; other site
880072000658	metal binding site [ion binding]; metal-binding site
880072000659	dimer interface [polypeptide binding]; other site
880072000660	Bacterial SH3 domain; Region: SH3_3; pfam08239
880072000661	Peptidase family M48; Region: Peptidase_M48; pfam01435
880072000662	probable DNA repair protein; Region: TIGR03623
880072000663	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
880072000664	Part of AAA domain; Region: AAA_19; pfam13245
880072000665	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
880072000666	Family description; Region: UvrD_C_2; pfam13538
880072000667	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
880072000668	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
880072000669	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
880072000670	homodimer interface [polypeptide binding]; other site
880072000671	substrate-cofactor binding pocket; other site
880072000672	catalytic residue [active]
880072000673	Autotransporter beta-domain; Region: Autotransporter; smart00869
880072000674	Calx-beta domain; Region: Calx-beta; pfam03160
880072000675	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
880072000676	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u5; cd10929
880072000677	putative active site [active]
880072000678	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
880072000679	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
880072000680	active site
880072000681	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
880072000682	This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812
880072000683	putative ADP-binding pocket [chemical binding]; other site
880072000684	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
880072000685	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
880072000686	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
880072000687	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
880072000688	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
880072000689	putative trimer interface [polypeptide binding]; other site
880072000690	Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132
880072000691	putative CoA binding site [chemical binding]; other site
880072000692	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
880072000693	putative trimer interface [polypeptide binding]; other site
880072000694	putative active site [active]
880072000695	putative substrate binding site [chemical binding]; other site
880072000696	putative CoA binding site [chemical binding]; other site
880072000697	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
880072000698	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
880072000699	NAD(P) binding site [chemical binding]; other site
880072000700	active site
880072000701	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
880072000702	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
880072000703	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
880072000704	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
880072000705	putative NAD(P) binding site [chemical binding]; other site
880072000706	active site
880072000707	putative substrate binding site [chemical binding]; other site
880072000708	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
880072000709	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
880072000710	NAD(P) binding site [chemical binding]; other site
880072000711	homodimer interface [polypeptide binding]; other site
880072000712	substrate binding site [chemical binding]; other site
880072000713	active site
880072000714	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
880072000715	exosortase D, VPLPA-CTERM-specific; Region: exosort_VPLPA; TIGR04152
880072000716	Protein of unknown function (DUF3485); Region: DUF3485; pfam11984
880072000717	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
880072000718	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
880072000719	putative trimer interface [polypeptide binding]; other site
880072000720	putative CoA binding site [chemical binding]; other site
880072000721	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
880072000722	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
880072000723	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
880072000724	inhibitor-cofactor binding pocket; inhibition site
880072000725	pyridoxal 5'-phosphate binding site [chemical binding]; other site
880072000726	catalytic residue [active]
880072000727	Bacterial sugar transferase; Region: Bac_transf; pfam02397
880072000728	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
880072000729	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
880072000730	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
880072000731	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
880072000732	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
880072000733	uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016
880072000734	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
880072000735	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
880072000736	SLBB domain; Region: SLBB; pfam10531
880072000737	intracellular protease, PfpI family; Region: PfpI; TIGR01382
880072000738	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
880072000739	proposed catalytic triad [active]
880072000740	conserved cys residue [active]
880072000741	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
880072000742	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
880072000743	alpha subunit interface [polypeptide binding]; other site
880072000744	TPP binding site [chemical binding]; other site
880072000745	heterodimer interface [polypeptide binding]; other site
880072000746	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
880072000747	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
880072000748	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
880072000749	TPP-binding site [chemical binding]; other site
880072000750	tetramer interface [polypeptide binding]; other site
880072000751	heterodimer interface [polypeptide binding]; other site
880072000752	phosphorylation loop region [posttranslational modification]
880072000753	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
880072000754	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
880072000755	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
880072000756	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
880072000757	DNA binding residues [nucleotide binding]
880072000758	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
880072000759	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
880072000760	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
880072000761	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
880072000762	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
880072000763	TrkA-N domain; Region: TrkA_N; pfam02254
880072000764	Protein of unknown function (DUF721); Region: DUF721; pfam05258
880072000765	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
880072000766	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
880072000767	active site
880072000768	HIGH motif; other site
880072000769	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
880072000770	KMSKS motif; other site
880072000771	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
880072000772	tRNA binding surface [nucleotide binding]; other site
880072000773	anticodon binding site; other site
880072000774	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
880072000775	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
880072000776	DXD motif; other site
880072000777	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
880072000778	active site
880072000779	substrate binding site [chemical binding]; other site
880072000780	cosubstrate binding site; other site
880072000781	catalytic site [active]
880072000782	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
880072000783	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072000784	TPR motif; other site
880072000785	binding surface
880072000786	YGGT family; Region: YGGT; pfam02325
880072000787	DivIVA domain; Region: DivI1A_domain; TIGR03544
880072000788	DivIVA protein; Region: DivIVA; pfam05103
880072000789	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
880072000790	chaperone protein DnaJ; Provisional; Region: PRK10767
880072000791	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
880072000792	HSP70 interaction site [polypeptide binding]; other site
880072000793	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
880072000794	substrate binding site [polypeptide binding]; other site
880072000795	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
880072000796	Zn binding sites [ion binding]; other site
880072000797	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
880072000798	dimer interface [polypeptide binding]; other site
880072000799	excinuclease ABC subunit B; Provisional; Region: PRK05298
880072000800	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
880072000801	ATP binding site [chemical binding]; other site
880072000802	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
880072000803	nucleotide binding region [chemical binding]; other site
880072000804	ATP-binding site [chemical binding]; other site
880072000805	Ultra-violet resistance protein B; Region: UvrB; pfam12344
880072000806	UvrB/uvrC motif; Region: UVR; pfam02151
880072000807	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
880072000808	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
880072000809	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
880072000810	dimerization interface [polypeptide binding]; other site
880072000811	putative ATP binding site [chemical binding]; other site
880072000812	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
880072000813	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
880072000814	DNA binding residues [nucleotide binding]
880072000815	purine nucleoside phosphorylase; Provisional; Region: PRK08202
880072000816	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
880072000817	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
880072000818	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
880072000819	active site
880072000820	dimer interface [polypeptide binding]; other site
880072000821	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
880072000822	Major Facilitator Superfamily; Region: MFS_1; pfam07690
880072000823	putative substrate translocation pore; other site
880072000824	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
880072000825	FOG: CBS domain [General function prediction only]; Region: COG0517
880072000826	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
880072000827	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
880072000828	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
880072000829	Na binding site [ion binding]; other site
880072000830	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
880072000831	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
880072000832	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072000833	dimer interface [polypeptide binding]; other site
880072000834	phosphorylation site [posttranslational modification]
880072000835	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072000836	ATP binding site [chemical binding]; other site
880072000837	Mg2+ binding site [ion binding]; other site
880072000838	G-X-G motif; other site
880072000839	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
880072000840	active site
880072000841	phosphorylation site [posttranslational modification]
880072000842	dimerization interface [polypeptide binding]; other site
880072000843	Response regulator receiver domain; Region: Response_reg; pfam00072
880072000844	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072000845	active site
880072000846	phosphorylation site [posttranslational modification]
880072000847	intermolecular recognition site; other site
880072000848	dimerization interface [polypeptide binding]; other site
880072000849	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072000850	dimer interface [polypeptide binding]; other site
880072000851	phosphorylation site [posttranslational modification]
880072000852	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072000853	ATP binding site [chemical binding]; other site
880072000854	Mg2+ binding site [ion binding]; other site
880072000855	G-X-G motif; other site
880072000856	Transglycosylase SLT domain; Region: SLT_2; pfam13406
880072000857	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
880072000858	N-acetyl-D-glucosamine binding site [chemical binding]; other site
880072000859	AIR carboxylase; Region: AIRC; pfam00731
880072000860	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
880072000861	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
880072000862	active site
880072000863	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
880072000864	dimer interface [polypeptide binding]; other site
880072000865	substrate binding site [chemical binding]; other site
880072000866	catalytic residues [active]
880072000867	Methyltransferase domain; Region: Methyltransf_23; pfam13489
880072000868	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072000869	S-adenosylmethionine binding site [chemical binding]; other site
880072000870	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
880072000871	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
880072000872	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
880072000873	active site
880072000874	HIGH motif; other site
880072000875	nucleotide binding site [chemical binding]; other site
880072000876	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
880072000877	KMSK motif region; other site
880072000878	tRNA binding surface [nucleotide binding]; other site
880072000879	DALR anticodon binding domain; Region: DALR_1; smart00836
880072000880	anticodon binding site; other site
880072000881	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
880072000882	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
880072000883	putative active site [active]
880072000884	oxyanion strand; other site
880072000885	catalytic triad [active]
880072000886	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
880072000887	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
880072000888	substrate binding site [chemical binding]; other site
880072000889	glutamase interaction surface [polypeptide binding]; other site
880072000890	alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392
880072000891	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
880072000892	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
880072000893	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
880072000894	DNA binding residues [nucleotide binding]
880072000895	TPR repeat; Region: TPR_11; pfam13414
880072000896	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072000897	binding surface
880072000898	TPR motif; other site
880072000899	TPR repeat; Region: TPR_11; pfam13414
880072000900	Tetratricopeptide repeat; Region: TPR_12; pfam13424
880072000901	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072000902	binding surface
880072000903	TPR motif; other site
880072000904	Tetratricopeptide repeat; Region: TPR_16; pfam13432
880072000905	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072000906	binding surface
880072000907	TPR motif; other site
880072000908	TPR repeat; Region: TPR_11; pfam13414
880072000909	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072000910	binding surface
880072000911	TPR motif; other site
880072000912	TPR repeat; Region: TPR_11; pfam13414
880072000913	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072000914	binding surface
880072000915	TPR motif; other site
880072000916	Tetratricopeptide repeat; Region: TPR_16; pfam13432
880072000917	TPR repeat; Region: TPR_11; pfam13414
880072000918	Domain of unknown function (DUF4292); Region: DUF4292; pfam14125
880072000919	Uncharacterized conserved protein [Function unknown]; Region: COG1656
880072000920	Protein of unknown function DUF82; Region: DUF82; pfam01927
880072000921	TPR repeat; Region: TPR_11; pfam13414
880072000922	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
880072000923	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
880072000924	Response regulator receiver domain; Region: Response_reg; pfam00072
880072000925	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072000926	active site
880072000927	phosphorylation site [posttranslational modification]
880072000928	intermolecular recognition site; other site
880072000929	dimerization interface [polypeptide binding]; other site
880072000930	Cache domain; Region: Cache_1; pfam02743
880072000931	PAS domain S-box; Region: sensory_box; TIGR00229
880072000932	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072000933	putative active site [active]
880072000934	heme pocket [chemical binding]; other site
880072000935	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
880072000936	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072000937	dimer interface [polypeptide binding]; other site
880072000938	phosphorylation site [posttranslational modification]
880072000939	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072000940	ATP binding site [chemical binding]; other site
880072000941	Mg2+ binding site [ion binding]; other site
880072000942	G-X-G motif; other site
880072000943	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
880072000944	active site clefts [active]
880072000945	zinc binding site [ion binding]; other site
880072000946	dimer interface [polypeptide binding]; other site
880072000947	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314
880072000948	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
880072000949	active site
880072000950	substrate binding site [chemical binding]; other site
880072000951	metal binding site [ion binding]; metal-binding site
880072000952	pantothenate kinase; Reviewed; Region: PRK13321
880072000953	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
880072000954	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
880072000955	Walker A/P-loop; other site
880072000956	ATP binding site [chemical binding]; other site
880072000957	Q-loop/lid; other site
880072000958	ABC transporter signature motif; other site
880072000959	Walker B; other site
880072000960	D-loop; other site
880072000961	H-loop/switch region; other site
880072000962	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
880072000963	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
880072000964	Walker A/P-loop; other site
880072000965	ATP binding site [chemical binding]; other site
880072000966	Q-loop/lid; other site
880072000967	ABC transporter signature motif; other site
880072000968	Walker B; other site
880072000969	D-loop; other site
880072000970	H-loop/switch region; other site
880072000971	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
880072000972	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
880072000973	TM-ABC transporter signature motif; other site
880072000974	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
880072000975	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
880072000976	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
880072000977	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
880072000978	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
880072000979	Ferredoxin [Energy production and conversion]; Region: NapF; COG1145
880072000980	4Fe-4S binding domain; Region: Fer4; pfam00037
880072000981	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
880072000982	Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225
880072000983	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
880072000984	FAD binding site [chemical binding]; other site
880072000985	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
880072000986	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
880072000987	TM-ABC transporter signature motif; other site
880072000988	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
880072000989	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
880072000990	putative ligand binding site [chemical binding]; other site
880072000991	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
880072000992	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
880072000993	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
880072000994	putative tRNA-binding site [nucleotide binding]; other site
880072000995	B3/4 domain; Region: B3_4; pfam03483
880072000996	tRNA synthetase B5 domain; Region: B5; smart00874
880072000997	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
880072000998	dimer interface [polypeptide binding]; other site
880072000999	motif 1; other site
880072001000	motif 3; other site
880072001001	motif 2; other site
880072001002	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
880072001003	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
880072001004	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
880072001005	DNA binding residues [nucleotide binding]
880072001006	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
880072001007	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
880072001008	HlyD family secretion protein; Region: HlyD_3; pfam13437
880072001009	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
880072001010	Protein export membrane protein; Region: SecD_SecF; cl14618
880072001011	4Fe-4S binding domain; Region: Fer4; cl02805
880072001012	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
880072001013	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
880072001014	endonuclease III; Region: ENDO3c; smart00478
880072001015	minor groove reading motif; other site
880072001016	helix-hairpin-helix signature motif; other site
880072001017	substrate binding pocket [chemical binding]; other site
880072001018	active site
880072001019	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
880072001020	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
880072001021	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
880072001022	active site
880072001023	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
880072001024	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
880072001025	Radical SAM superfamily; Region: Radical_SAM; pfam04055
880072001026	FeS/SAM binding site; other site
880072001027	alanine dehydrogenase; Validated; Region: PRK06046
880072001028	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
880072001029	glucose-6-phosphate isomerase; Provisional; Region: PRK00973
880072001030	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
880072001031	active site
880072001032	dimer interface [polypeptide binding]; other site
880072001033	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
880072001034	dimer interface [polypeptide binding]; other site
880072001035	active site
880072001036	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072001037	dimer interface [polypeptide binding]; other site
880072001038	phosphorylation site [posttranslational modification]
880072001039	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072001040	ATP binding site [chemical binding]; other site
880072001041	Mg2+ binding site [ion binding]; other site
880072001042	G-X-G motif; other site
880072001043	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
880072001044	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072001045	active site
880072001046	phosphorylation site [posttranslational modification]
880072001047	intermolecular recognition site; other site
880072001048	dimerization interface [polypeptide binding]; other site
880072001049	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072001050	Walker A motif; other site
880072001051	ATP binding site [chemical binding]; other site
880072001052	Walker B motif; other site
880072001053	arginine finger; other site
880072001054	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
880072001055	threonine synthase; Validated; Region: PRK06260
880072001056	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
880072001057	homodimer interface [polypeptide binding]; other site
880072001058	pyridoxal 5'-phosphate binding site [chemical binding]; other site
880072001059	catalytic residue [active]
880072001060	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
880072001061	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
880072001062	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
880072001063	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
880072001064	active site residue [active]
880072001065	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
880072001066	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
880072001067	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
880072001068	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
880072001069	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
880072001070	Ferrous iron transport protein B; Region: FeoB_N; pfam02421
880072001071	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
880072001072	G1 box; other site
880072001073	GTP/Mg2+ binding site [chemical binding]; other site
880072001074	Switch I region; other site
880072001075	G2 box; other site
880072001076	G3 box; other site
880072001077	Switch II region; other site
880072001078	G4 box; other site
880072001079	G5 box; other site
880072001080	Nucleoside recognition; Region: Gate; pfam07670
880072001081	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
880072001082	Nucleoside recognition; Region: Gate; pfam07670
880072001083	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
880072001084	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
880072001085	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
880072001086	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
880072001087	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
880072001088	N-terminal plug; other site
880072001089	ligand-binding site [chemical binding]; other site
880072001090	Predicted transporter (DUF2162); Region: DUF2162; cl01990
880072001091	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
880072001092	Uncharacterized conserved protein (DUF2149); Region: DUF2149; pfam09919
880072001093	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
880072001094	CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514
880072001095	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
880072001096	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
880072001097	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
880072001098	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
880072001099	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
880072001100	nitrogenase reductase; Reviewed; Region: nifH; PRK13235
880072001101	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
880072001102	Nucleotide-binding sites [chemical binding]; other site
880072001103	Walker A motif; other site
880072001104	Switch I region of nucleotide binding site; other site
880072001105	Fe4S4 binding sites [ion binding]; other site
880072001106	Switch II region of nucleotide binding site; other site
880072001107	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
880072001108	Nitrogen regulatory protein P-II; Region: P-II; smart00938
880072001109	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
880072001110	Nitrogen regulatory protein P-II; Region: P-II; smart00938
880072001111	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
880072001112	MoFe protein alpha/beta subunit interactions; other site
880072001113	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
880072001114	Alpha subunit P cluster binding residues; other site
880072001115	FeMoco binding residues [chemical binding]; other site
880072001116	MoFe protein alpha subunit/Fe protein contacts; other site
880072001117	MoFe protein dimer/ dimer interactions; other site
880072001118	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
880072001119	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
880072001120	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
880072001121	dimer interface [polypeptide binding]; other site
880072001122	[2Fe-2S] cluster binding site [ion binding]; other site
880072001123	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
880072001124	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
880072001125	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
880072001126	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
880072001127	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
880072001128	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
880072001129	FeS/SAM binding site; other site
880072001130	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
880072001131	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
880072001132	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
880072001133	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
880072001134	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
880072001135	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
880072001136	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
880072001137	Walker A/P-loop; other site
880072001138	ATP binding site [chemical binding]; other site
880072001139	Q-loop/lid; other site
880072001140	ABC transporter signature motif; other site
880072001141	Walker B; other site
880072001142	D-loop; other site
880072001143	H-loop/switch region; other site
880072001144	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
880072001145	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
880072001146	Walker A/P-loop; other site
880072001147	ATP binding site [chemical binding]; other site
880072001148	Q-loop/lid; other site
880072001149	ABC transporter signature motif; other site
880072001150	Walker B; other site
880072001151	D-loop; other site
880072001152	H-loop/switch region; other site
880072001153	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
880072001154	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
880072001155	HlyD family secretion protein; Region: HlyD_3; pfam13437
880072001156	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
880072001157	putative FMN binding site [chemical binding]; other site
880072001158	NADPH bind site [chemical binding]; other site
880072001159	N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
880072001160	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
880072001161	active site
880072001162	putative substrate binding pocket [chemical binding]; other site
880072001163	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
880072001164	N-acetyl-D-glucosamine binding site [chemical binding]; other site
880072001165	catalytic residue [active]
880072001166	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cd09852
880072001167	putative active site [active]
880072001168	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
880072001169	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
880072001170	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
880072001171	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
880072001172	active site
880072001173	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
880072001174	substrate binding pocket [chemical binding]; other site
880072001175	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
880072001176	FMN binding site [chemical binding]; other site
880072001177	dimer interface [polypeptide binding]; other site
880072001178	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
880072001179	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
880072001180	active site
880072001181	HIGH motif; other site
880072001182	dimer interface [polypeptide binding]; other site
880072001183	KMSKS motif; other site
880072001184	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
880072001185	RNA binding surface [nucleotide binding]; other site
880072001186	Tim44-like domain; Region: Tim44; pfam04280
880072001187	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
880072001188	DHH family; Region: DHH; pfam01368
880072001189	DHHA1 domain; Region: DHHA1; pfam02272
880072001190	FOG: CBS domain [General function prediction only]; Region: COG0517
880072001191	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595
880072001192	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
880072001193	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
880072001194	active site
880072001195	NTP binding site [chemical binding]; other site
880072001196	metal binding triad [ion binding]; metal-binding site
880072001197	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
880072001198	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
880072001199	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
880072001200	active site
880072001201	Int/Topo IB signature motif; other site
880072001202	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
880072001203	Protein of unknown function (DUF1385); Region: DUF1385; pfam07136
880072001204	peptide chain release factor 1; Validated; Region: prfA; PRK00591
880072001205	This domain is found in peptide chain release factors; Region: PCRF; smart00937
880072001206	RF-1 domain; Region: RF-1; pfam00472
880072001207	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
880072001208	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072001209	S-adenosylmethionine binding site [chemical binding]; other site
880072001210	DHH family; Region: DHH; pfam01368
880072001211	aspartate aminotransferase; Provisional; Region: PRK06836
880072001212	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
880072001213	pyridoxal 5'-phosphate binding site [chemical binding]; other site
880072001214	homodimer interface [polypeptide binding]; other site
880072001215	catalytic residue [active]
880072001216	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
880072001217	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
880072001218	active site
880072001219	metal binding site [ion binding]; metal-binding site
880072001220	homotetramer interface [polypeptide binding]; other site
880072001221	Methyltransferase domain; Region: Methyltransf_23; pfam13489
880072001222	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072001223	S-adenosylmethionine binding site [chemical binding]; other site
880072001224	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
880072001225	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
880072001226	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
880072001227	FeS/SAM binding site; other site
880072001228	Domain of unknown function DUF39; Region: DUF39; pfam01837
880072001229	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
880072001230	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
880072001231	Ligand Binding Site [chemical binding]; other site
880072001232	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
880072001233	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
880072001234	Zn2+ binding site [ion binding]; other site
880072001235	Mg2+ binding site [ion binding]; other site
880072001236	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
880072001237	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
880072001238	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
880072001239	Ligand Binding Site [chemical binding]; other site
880072001240	Domain of unknown function (DUF814); Region: DUF814; pfam05670
880072001241	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
880072001242	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072001243	S-adenosylmethionine binding site [chemical binding]; other site
880072001244	NMT1/THI5 like; Region: NMT1; pfam09084
880072001245	Cache domain; Region: Cache_1; pfam02743
880072001246	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
880072001247	dimerization interface [polypeptide binding]; other site
880072001248	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
880072001249	cyclase homology domain; Region: CHD; cd07302
880072001250	nucleotidyl binding site; other site
880072001251	metal binding site [ion binding]; metal-binding site
880072001252	dimer interface [polypeptide binding]; other site
880072001253	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
880072001254	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
880072001255	catalytic residues [active]
880072001256	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
880072001257	Ligand Binding Site [chemical binding]; other site
880072001258	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
880072001259	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
880072001260	putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055
880072001261	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
880072001262	FeS/SAM binding site; other site
880072001263	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
880072001264	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
880072001265	dimer interface [polypeptide binding]; other site
880072001266	active site
880072001267	Schiff base residues; other site
880072001268	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
880072001269	Protein of unknown function (DUF523); Region: DUF523; pfam04463
880072001270	Uncharacterized conserved protein [Function unknown]; Region: COG3272
880072001271	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
880072001272	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
880072001273	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
880072001274	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
880072001275	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
880072001276	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
880072001277	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
880072001278	active site
880072001279	catalytic site [active]
880072001280	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
880072001281	homodimer interaction site [polypeptide binding]; other site
880072001282	cofactor binding site; other site
880072001283	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
880072001284	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
880072001285	domain interfaces; other site
880072001286	active site
880072001287	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
880072001288	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
880072001289	catalytic loop [active]
880072001290	iron binding site [ion binding]; other site
880072001291	amino acid transporter; Region: 2A0306; TIGR00909
880072001292	Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins; Region: DHR2_DOCK; cl06123
880072001293	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
880072001294	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
880072001295	Active site cavity [active]
880072001296	catalytic acid [active]
880072001297	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
880072001298	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
880072001299	putative NADP binding site [chemical binding]; other site
880072001300	putative substrate binding site [chemical binding]; other site
880072001301	active site
880072001302	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
880072001303	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
880072001304	FeS/SAM binding site; other site
880072001305	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
880072001306	Surface antigen; Region: Bac_surface_Ag; pfam01103
880072001307	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
880072001308	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
880072001309	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
880072001310	trigger factor; Region: tig; TIGR00115
880072001311	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
880072001312	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
880072001313	Clp protease; Region: CLP_protease; pfam00574
880072001314	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
880072001315	oligomer interface [polypeptide binding]; other site
880072001316	active site residues [active]
880072001317	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
880072001318	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
880072001319	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072001320	Walker A motif; other site
880072001321	ATP binding site [chemical binding]; other site
880072001322	Walker B motif; other site
880072001323	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
880072001324	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
880072001325	Found in ATP-dependent protease La (LON); Region: LON; smart00464
880072001326	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072001327	Walker A motif; other site
880072001328	ATP binding site [chemical binding]; other site
880072001329	Walker B motif; other site
880072001330	arginine finger; other site
880072001331	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
880072001332	Divergent AAA domain; Region: AAA_4; pfam04326
880072001333	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
880072001334	Predicted transcriptional regulator [Transcription]; Region: COG2944
880072001335	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
880072001336	non-specific DNA binding site [nucleotide binding]; other site
880072001337	salt bridge; other site
880072001338	sequence-specific DNA binding site [nucleotide binding]; other site
880072001339	Protein of unknown function (DUF497); Region: DUF497; pfam04365
880072001340	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
880072001341	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
880072001342	putative active site [active]
880072001343	V4R domain; Region: V4R; cl15268
880072001344	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
880072001345	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
880072001346	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072001347	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
880072001348	putative active site [active]
880072001349	heme pocket [chemical binding]; other site
880072001350	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072001351	dimer interface [polypeptide binding]; other site
880072001352	phosphorylation site [posttranslational modification]
880072001353	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072001354	ATP binding site [chemical binding]; other site
880072001355	Mg2+ binding site [ion binding]; other site
880072001356	G-X-G motif; other site
880072001357	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
880072001358	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072001359	active site
880072001360	phosphorylation site [posttranslational modification]
880072001361	intermolecular recognition site; other site
880072001362	dimerization interface [polypeptide binding]; other site
880072001363	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
880072001364	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
880072001365	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
880072001366	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
880072001367	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
880072001368	Ligand Binding Site [chemical binding]; other site
880072001369	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
880072001370	Ligand Binding Site [chemical binding]; other site
880072001371	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
880072001372	Ligand Binding Site [chemical binding]; other site
880072001373	Response regulator receiver domain; Region: Response_reg; pfam00072
880072001374	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072001375	active site
880072001376	phosphorylation site [posttranslational modification]
880072001377	intermolecular recognition site; other site
880072001378	dimerization interface [polypeptide binding]; other site
880072001379	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
880072001380	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700
880072001381	Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; cl09826
880072001382	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
880072001383	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
880072001384	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072001385	active site
880072001386	phosphorylation site [posttranslational modification]
880072001387	intermolecular recognition site; other site
880072001388	dimerization interface [polypeptide binding]; other site
880072001389	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072001390	Walker A motif; other site
880072001391	ATP binding site [chemical binding]; other site
880072001392	Walker B motif; other site
880072001393	arginine finger; other site
880072001394	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
880072001395	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
880072001396	HAMP domain; Region: HAMP; pfam00672
880072001397	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072001398	dimer interface [polypeptide binding]; other site
880072001399	phosphorylation site [posttranslational modification]
880072001400	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072001401	ATP binding site [chemical binding]; other site
880072001402	Mg2+ binding site [ion binding]; other site
880072001403	G-X-G motif; other site
880072001404	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
880072001405	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072001406	active site
880072001407	phosphorylation site [posttranslational modification]
880072001408	intermolecular recognition site; other site
880072001409	dimerization interface [polypeptide binding]; other site
880072001410	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072001411	PAS domain; Region: PAS_9; pfam13426
880072001412	putative active site [active]
880072001413	heme pocket [chemical binding]; other site
880072001414	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
880072001415	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
880072001416	active site
880072001417	ATP binding site [chemical binding]; other site
880072001418	substrate binding site [chemical binding]; other site
880072001419	activation loop (A-loop); other site
880072001420	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
880072001421	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
880072001422	Walker A/P-loop; other site
880072001423	ATP binding site [chemical binding]; other site
880072001424	Q-loop/lid; other site
880072001425	ABC transporter signature motif; other site
880072001426	Walker B; other site
880072001427	D-loop; other site
880072001428	H-loop/switch region; other site
880072001429	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
880072001430	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
880072001431	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
880072001432	Walker A/P-loop; other site
880072001433	ATP binding site [chemical binding]; other site
880072001434	Q-loop/lid; other site
880072001435	ABC transporter signature motif; other site
880072001436	Walker B; other site
880072001437	D-loop; other site
880072001438	H-loop/switch region; other site
880072001439	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
880072001440	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
880072001441	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072001442	putative active site [active]
880072001443	heme pocket [chemical binding]; other site
880072001444	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072001445	dimer interface [polypeptide binding]; other site
880072001446	phosphorylation site [posttranslational modification]
880072001447	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072001448	ATP binding site [chemical binding]; other site
880072001449	Mg2+ binding site [ion binding]; other site
880072001450	G-X-G motif; other site
880072001451	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
880072001452	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
880072001453	dimer interface [polypeptide binding]; other site
880072001454	active site
880072001455	hypothetical protein; Provisional; Region: PHA02965
880072001456	Methyltransferase domain; Region: Methyltransf_31; pfam13847
880072001457	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072001458	S-adenosylmethionine binding site [chemical binding]; other site
880072001459	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710
880072001460	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
880072001461	acyl-activating enzyme (AAE) consensus motif; other site
880072001462	putative AMP binding site [chemical binding]; other site
880072001463	putative active site [active]
880072001464	putative CoA binding site [chemical binding]; other site
880072001465	thiamine monophosphate kinase; Provisional; Region: PRK05731
880072001466	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
880072001467	ATP binding site [chemical binding]; other site
880072001468	dimerization interface [polypeptide binding]; other site
880072001469	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
880072001470	active site
880072001471	multimer interface [polypeptide binding]; other site
880072001472	elongation factor G; Reviewed; Region: PRK00007
880072001473	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
880072001474	G1 box; other site
880072001475	putative GEF interaction site [polypeptide binding]; other site
880072001476	GTP/Mg2+ binding site [chemical binding]; other site
880072001477	Switch I region; other site
880072001478	G2 box; other site
880072001479	G3 box; other site
880072001480	Switch II region; other site
880072001481	G4 box; other site
880072001482	G5 box; other site
880072001483	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
880072001484	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cd01680
880072001485	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
880072001486	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
880072001487	Cysteine-rich domain; Region: CCG; pfam02754
880072001488	Domain of unknown function (DUF1858); Region: DUF1858; cl14817
880072001489	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
880072001490	SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain.  The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY,  and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421
880072001491	CPxP  motif; other site
880072001492	putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112
880072001493	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
880072001494	dimerization interface [polypeptide binding]; other site
880072001495	putative ATP binding site [chemical binding]; other site
880072001496	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
880072001497	Creatinine amidohydrolase; Region: Creatininase; pfam02633
880072001498	GTP-binding protein Der; Reviewed; Region: PRK00093
880072001499	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
880072001500	G1 box; other site
880072001501	GTP/Mg2+ binding site [chemical binding]; other site
880072001502	Switch I region; other site
880072001503	G2 box; other site
880072001504	Switch II region; other site
880072001505	G3 box; other site
880072001506	G4 box; other site
880072001507	G5 box; other site
880072001508	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
880072001509	G1 box; other site
880072001510	GTP/Mg2+ binding site [chemical binding]; other site
880072001511	Switch I region; other site
880072001512	G2 box; other site
880072001513	G3 box; other site
880072001514	Switch II region; other site
880072001515	G4 box; other site
880072001516	G5 box; other site
880072001517	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
880072001518	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
880072001519	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
880072001520	protein binding site [polypeptide binding]; other site
880072001521	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
880072001522	Catalytic dyad [active]
880072001523	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
880072001524	C-terminal peptidase (prc); Region: prc; TIGR00225
880072001525	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
880072001526	protein binding site [polypeptide binding]; other site
880072001527	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
880072001528	Catalytic dyad [active]
880072001529	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
880072001530	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
880072001531	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
880072001532	Bacitracin resistance protein BacA; Region: BacA; pfam02673
880072001533	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
880072001534	Permease; Region: Permease; pfam02405
880072001535	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
880072001536	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
880072001537	Walker A/P-loop; other site
880072001538	ATP binding site [chemical binding]; other site
880072001539	Q-loop/lid; other site
880072001540	ABC transporter signature motif; other site
880072001541	Walker B; other site
880072001542	D-loop; other site
880072001543	H-loop/switch region; other site
880072001544	cobalamin synthase; Reviewed; Region: cobS; PRK00235
880072001545	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
880072001546	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
880072001547	putative dimer interface [polypeptide binding]; other site
880072001548	active site pocket [active]
880072001549	putative cataytic base [active]
880072001550	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
880072001551	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
880072001552	homotrimer interface [polypeptide binding]; other site
880072001553	Walker A motif; other site
880072001554	GTP binding site [chemical binding]; other site
880072001555	Walker B motif; other site
880072001556	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572
880072001557	ABC-2 type transporter; Region: ABC2_membrane; cl17235
880072001558	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
880072001559	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
880072001560	Nitrogen regulatory protein P-II; Region: P-II; smart00938
880072001561	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
880072001562	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
880072001563	Walker A; other site
880072001564	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
880072001565	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
880072001566	substrate binding site [chemical binding]; other site
880072001567	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
880072001568	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
880072001569	homodimer interface [polypeptide binding]; other site
880072001570	oligonucleotide binding site [chemical binding]; other site
880072001571	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
880072001572	DNA polymerase III subunit beta; Validated; Region: PRK05643
880072001573	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
880072001574	putative DNA binding surface [nucleotide binding]; other site
880072001575	dimer interface [polypeptide binding]; other site
880072001576	beta-clamp/clamp loader binding surface; other site
880072001577	beta-clamp/translesion DNA polymerase binding surface; other site
880072001578	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
880072001579	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072001580	Mg2+ binding site [ion binding]; other site
880072001581	G-X-G motif; other site
880072001582	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
880072001583	anchoring element; other site
880072001584	dimer interface [polypeptide binding]; other site
880072001585	ATP binding site [chemical binding]; other site
880072001586	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
880072001587	active site
880072001588	putative metal-binding site [ion binding]; other site
880072001589	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
880072001590	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
880072001591	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
880072001592	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
880072001593	DNA binding residues [nucleotide binding]
880072001594	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
880072001595	Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792
880072001596	PAS domain S-box; Region: sensory_box; TIGR00229
880072001597	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072001598	putative active site [active]
880072001599	heme pocket [chemical binding]; other site
880072001600	GAF domain; Region: GAF_2; pfam13185
880072001601	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
880072001602	PAS domain S-box; Region: sensory_box; TIGR00229
880072001603	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072001604	putative active site [active]
880072001605	heme pocket [chemical binding]; other site
880072001606	PAS domain S-box; Region: sensory_box; TIGR00229
880072001607	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072001608	putative active site [active]
880072001609	heme pocket [chemical binding]; other site
880072001610	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072001611	dimer interface [polypeptide binding]; other site
880072001612	phosphorylation site [posttranslational modification]
880072001613	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072001614	ATP binding site [chemical binding]; other site
880072001615	Mg2+ binding site [ion binding]; other site
880072001616	G-X-G motif; other site
880072001617	Response regulator receiver domain; Region: Response_reg; pfam00072
880072001618	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072001619	active site
880072001620	phosphorylation site [posttranslational modification]
880072001621	intermolecular recognition site; other site
880072001622	dimerization interface [polypeptide binding]; other site
880072001623	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
880072001624	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072001625	binding surface
880072001626	TPR motif; other site
880072001627	Tetratricopeptide repeat; Region: TPR_16; pfam13432
880072001628	Tetratricopeptide repeat; Region: TPR_16; pfam13432
880072001629	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
880072001630	CoA-transferase family III; Region: CoA_transf_3; pfam02515
880072001631	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
880072001632	CoA-transferase family III; Region: CoA_transf_3; pfam02515
880072001633	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072001634	PAS domain; Region: PAS_9; pfam13426
880072001635	putative active site [active]
880072001636	heme pocket [chemical binding]; other site
880072001637	PAS domain S-box; Region: sensory_box; TIGR00229
880072001638	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072001639	putative active site [active]
880072001640	heme pocket [chemical binding]; other site
880072001641	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
880072001642	GAF domain; Region: GAF_3; pfam13492
880072001643	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072001644	Walker A motif; other site
880072001645	ATP binding site [chemical binding]; other site
880072001646	Walker B motif; other site
880072001647	arginine finger; other site
880072001648	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
880072001649	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
880072001650	active site
880072001651	NTP binding site [chemical binding]; other site
880072001652	metal binding triad [ion binding]; metal-binding site
880072001653	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
880072001654	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
880072001655	Zn2+ binding site [ion binding]; other site
880072001656	Mg2+ binding site [ion binding]; other site
880072001657	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
880072001658	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
880072001659	intersubunit interface [polypeptide binding]; other site
880072001660	active site
880072001661	Zn2+ binding site [ion binding]; other site
880072001662	SIR2-like domain; Region: SIR2_2; pfam13289
880072001663	Asp23 family; Region: Asp23; cl00574
880072001664	inosine-5'-monophosphate dehydrogenase; Provisional; Region: PTZ00314
880072001665	UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773
880072001666	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
880072001667	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
880072001668	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
880072001669	Beta-lactamase; Region: Beta-lactamase; cl17358
880072001670	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
880072001671	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
880072001672	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
880072001673	ATP-grasp domain; Region: ATP-grasp_4; cl17255
880072001674	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
880072001675	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
880072001676	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
880072001677	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
880072001678	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
880072001679	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
880072001680	Predicted permeases [General function prediction only]; Region: COG0795
880072001681	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
880072001682	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
880072001683	Radical SAM superfamily; Region: Radical_SAM; pfam04055
880072001684	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
880072001685	FeS/SAM binding site; other site
880072001686	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
880072001687	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
880072001688	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072001689	putative active site [active]
880072001690	heme pocket [chemical binding]; other site
880072001691	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
880072001692	Histidine kinase; Region: HisKA_2; pfam07568
880072001693	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072001694	ATP binding site [chemical binding]; other site
880072001695	Mg2+ binding site [ion binding]; other site
880072001696	G-X-G motif; other site
880072001697	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
880072001698	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072001699	active site
880072001700	phosphorylation site [posttranslational modification]
880072001701	intermolecular recognition site; other site
880072001702	dimerization interface [polypeptide binding]; other site
880072001703	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
880072001704	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
880072001705	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
880072001706	dimer interface [polypeptide binding]; other site
880072001707	phosphorylation site [posttranslational modification]
880072001708	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072001709	ATP binding site [chemical binding]; other site
880072001710	Mg2+ binding site [ion binding]; other site
880072001711	G-X-G motif; other site
880072001712	Response regulator receiver domain; Region: Response_reg; pfam00072
880072001713	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072001714	active site
880072001715	phosphorylation site [posttranslational modification]
880072001716	intermolecular recognition site; other site
880072001717	dimerization interface [polypeptide binding]; other site
880072001718	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
880072001719	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
880072001720	active site
880072001721	tetramer interface [polypeptide binding]; other site
880072001722	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
880072001723	active site
880072001724	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
880072001725	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072001726	S-adenosylmethionine binding site [chemical binding]; other site
880072001727	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
880072001728	TAP-like protein; Region: Abhydrolase_4; pfam08386
880072001729	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
880072001730	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
880072001731	substrate-cofactor binding pocket; other site
880072001732	pyridoxal 5'-phosphate binding site [chemical binding]; other site
880072001733	catalytic residue [active]
880072001734	AAA domain; Region: AAA_26; pfam13500
880072001735	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
880072001736	biotin synthase; Region: bioB; TIGR00433
880072001737	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
880072001738	FeS/SAM binding site; other site
880072001739	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
880072001740	Outer membrane lipoprotein Slp family; Region: Slp; pfam03843
880072001741	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
880072001742	Protein of unknown function (DUF1640); Region: DUF1640; pfam07798
880072001743	Helix-turn-helix domain; Region: HTH_17; pfam12728
880072001744	AAA domain; Region: AAA_25; pfam13481
880072001745	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
880072001746	ATP binding site [chemical binding]; other site
880072001747	Walker A motif; other site
880072001748	Walker B motif; other site
880072001749	Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; pfam08273
880072001750	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
880072001751	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
880072001752	Ribosomal protein S27a; Region: Ribosomal_S27; cl00876
880072001753	Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659
880072001754	ERCC4 domain; Region: ERCC4; pfam02732
880072001755	Transcriptional Coactivator p15 (PC4); Region: PC4; pfam02229
880072001756	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
880072001757	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
880072001758	active site
880072001759	DNA binding site [nucleotide binding]
880072001760	Int/Topo IB signature motif; other site
880072001761	pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622
880072001762	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
880072001763	dimer interface [polypeptide binding]; other site
880072001764	PYR/PP interface [polypeptide binding]; other site
880072001765	TPP binding site [chemical binding]; other site
880072001766	substrate binding site [chemical binding]; other site
880072001767	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
880072001768	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
880072001769	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013
880072001770	TPP-binding site [chemical binding]; other site
880072001771	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
880072001772	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
880072001773	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
880072001774	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
880072001775	active site
880072001776	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
880072001777	Ligand binding site [chemical binding]; other site
880072001778	Electron transfer flavoprotein domain; Region: ETF; pfam01012
880072001779	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
880072001780	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
880072001781	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
880072001782	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
880072001783	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
880072001784	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
880072001785	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
880072001786	NAD(P) binding site [chemical binding]; other site
880072001787	active site
880072001788	acyl carrier protein; Provisional; Region: acpP; PRK00982
880072001789	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
880072001790	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
880072001791	dimer interface [polypeptide binding]; other site
880072001792	active site
880072001793	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
880072001794	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
880072001795	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
880072001796	dimer interface [polypeptide binding]; other site
880072001797	active site
880072001798	glycine-pyridoxal phosphate binding site [chemical binding]; other site
880072001799	folate binding site [chemical binding]; other site
880072001800	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
880072001801	ATP cone domain; Region: ATP-cone; pfam03477
880072001802	HEPN domain; Region: HEPN; cl00824
880072001803	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
880072001804	DNA methylase; Region: N6_N4_Mtase; pfam01555
880072001805	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
880072001806	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
880072001807	catalytic motif [active]
880072001808	Zn binding site [ion binding]; other site
880072001809	RibD C-terminal domain; Region: RibD_C; cl17279
880072001810	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
880072001811	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
880072001812	dimer interface [polypeptide binding]; other site
880072001813	motif 1; other site
880072001814	active site
880072001815	motif 2; other site
880072001816	motif 3; other site
880072001817	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
880072001818	anticodon binding site; other site
880072001819	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
880072001820	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
880072001821	dimer interface [polypeptide binding]; other site
880072001822	anticodon binding site; other site
880072001823	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
880072001824	homodimer interface [polypeptide binding]; other site
880072001825	motif 1; other site
880072001826	active site
880072001827	motif 2; other site
880072001828	GAD domain; Region: GAD; pfam02938
880072001829	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
880072001830	motif 3; other site
880072001831	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
880072001832	Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947
880072001833	active site
880072001834	catalytic residues [active]
880072001835	metal binding site [ion binding]; metal-binding site
880072001836	Cache domain; Region: Cache_1; pfam02743
880072001837	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
880072001838	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
880072001839	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
880072001840	active site
880072001841	metal binding site [ion binding]; metal-binding site
880072001842	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680
880072001843	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
880072001844	B12 binding site [chemical binding]; other site
880072001845	cobalt ligand [ion binding]; other site
880072001846	pyruvate kinase; Provisional; Region: PRK05826
880072001847	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
880072001848	domain interfaces; other site
880072001849	active site
880072001850	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
880072001851	phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972
880072001852	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
880072001853	Walker A/P-loop; other site
880072001854	ATP binding site [chemical binding]; other site
880072001855	Q-loop/lid; other site
880072001856	ABC transporter signature motif; other site
880072001857	Walker B; other site
880072001858	D-loop; other site
880072001859	H-loop/switch region; other site
880072001860	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
880072001861	dimer interface [polypeptide binding]; other site
880072001862	conserved gate region; other site
880072001863	putative PBP binding loops; other site
880072001864	ABC-ATPase subunit interface; other site
880072001865	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
880072001866	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
880072001867	dimer interface [polypeptide binding]; other site
880072001868	conserved gate region; other site
880072001869	putative PBP binding loops; other site
880072001870	ABC-ATPase subunit interface; other site
880072001871	PBP superfamily domain; Region: PBP_like_2; cl17296
880072001872	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
880072001873	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
880072001874	Radical SAM superfamily; Region: Radical_SAM; pfam04055
880072001875	FeS/SAM binding site; other site
880072001876	ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163
880072001877	4Fe-4S binding domain; Region: Fer4_5; pfam12801
880072001878	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
880072001879	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
880072001880	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
880072001881	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
880072001882	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
880072001883	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
880072001884	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
880072001885	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
880072001886	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
880072001887	Walker A/P-loop; other site
880072001888	ATP binding site [chemical binding]; other site
880072001889	Q-loop/lid; other site
880072001890	ABC transporter signature motif; other site
880072001891	Walker B; other site
880072001892	D-loop; other site
880072001893	H-loop/switch region; other site
880072001894	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
880072001895	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
880072001896	ABC-ATPase subunit  interface; other site
880072001897	dimer interface [polypeptide binding]; other site
880072001898	putative PBP binding regions; other site
880072001899	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
880072001900	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
880072001901	cobalamin binding residues [chemical binding]; other site
880072001902	putative BtuC binding residues; other site
880072001903	dimer interface [polypeptide binding]; other site
880072001904	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
880072001905	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
880072001906	intersubunit interface [polypeptide binding]; other site
880072001907	Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955
880072001908	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
880072001909	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
880072001910	N-terminal plug; other site
880072001911	ligand-binding site [chemical binding]; other site
880072001912	PAS domain; Region: PAS; smart00091
880072001913	PAS fold; Region: PAS_4; pfam08448
880072001914	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
880072001915	dimer interface [polypeptide binding]; other site
880072001916	phosphorylation site [posttranslational modification]
880072001917	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072001918	ATP binding site [chemical binding]; other site
880072001919	Mg2+ binding site [ion binding]; other site
880072001920	G-X-G motif; other site
880072001921	Response regulator receiver domain; Region: Response_reg; pfam00072
880072001922	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072001923	active site
880072001924	phosphorylation site [posttranslational modification]
880072001925	intermolecular recognition site; other site
880072001926	dimerization interface [polypeptide binding]; other site
880072001927	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
880072001928	cell division protein FtsZ; Validated; Region: PRK09330
880072001929	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
880072001930	nucleotide binding site [chemical binding]; other site
880072001931	SulA interaction site; other site
880072001932	cell division protein FtsA; Region: ftsA; TIGR01174
880072001933	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
880072001934	nucleotide binding site [chemical binding]; other site
880072001935	SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491
880072001936	Cell division protein FtsA; Region: FtsA; pfam14450
880072001937	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
880072001938	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
880072001939	Cell division protein FtsQ; Region: FtsQ; pfam03799
880072001940	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
880072001941	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
880072001942	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
880072001943	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
880072001944	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
880072001945	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
880072001946	active site
880072001947	homodimer interface [polypeptide binding]; other site
880072001948	cell division protein FtsW; Region: ftsW; TIGR02614
880072001949	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106
880072001950	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
880072001951	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
880072001952	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
880072001953	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
880072001954	Mg++ binding site [ion binding]; other site
880072001955	putative catalytic motif [active]
880072001956	putative substrate binding site [chemical binding]; other site
880072001957	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
880072001958	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
880072001959	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
880072001960	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
880072001961	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
880072001962	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
880072001963	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
880072001964	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
880072001965	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
880072001966	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
880072001967	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
880072001968	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
880072001969	Cell division protein FtsL; Region: FtsL; cl11433
880072001970	MraW methylase family; Region: Methyltransf_5; cl17771
880072001971	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
880072001972	cell division protein MraZ; Reviewed; Region: PRK00326
880072001973	MraZ protein; Region: MraZ; pfam02381
880072001974	MraZ protein; Region: MraZ; pfam02381
880072001975	lipoyl synthase; Provisional; Region: PRK05481
880072001976	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
880072001977	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
880072001978	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
880072001979	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
880072001980	Predicted membrane protein (DUF2335); Region: DUF2335; pfam10097
880072001981	DNA methylase; Region: N6_N4_Mtase; cl17433
880072001982	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
880072001983	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
880072001984	active site
880072001985	NTP binding site [chemical binding]; other site
880072001986	metal binding triad [ion binding]; metal-binding site
880072001987	antibiotic binding site [chemical binding]; other site
880072001988	Uncharacterized conserved protein [Function unknown]; Region: COG2361
880072001989	TIGR02594 family protein; Region: TIGR02594
880072001990	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
880072001991	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
880072001992	non-specific DNA binding site [nucleotide binding]; other site
880072001993	salt bridge; other site
880072001994	sequence-specific DNA binding site [nucleotide binding]; other site
880072001995	Domain of unknown function (DUF955); Region: DUF955; cl01076
880072001996	Transposase [DNA replication, recombination, and repair]; Region: COG5421
880072001997	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
880072001998	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
880072001999	Zn2+ binding site [ion binding]; other site
880072002000	Mg2+ binding site [ion binding]; other site
880072002001	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
880072002002	nucleoside/Zn binding site; other site
880072002003	dimer interface [polypeptide binding]; other site
880072002004	catalytic motif [active]
880072002005	N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
880072002006	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
880072002007	active site
880072002008	putative substrate binding pocket [chemical binding]; other site
880072002009	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072002010	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
880072002011	Walker A motif; other site
880072002012	ATP binding site [chemical binding]; other site
880072002013	Walker B motif; other site
880072002014	arginine finger; other site
880072002015	Helix-turn-helix domain; Region: HTH_28; pfam13518
880072002016	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
880072002017	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
880072002018	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
880072002019	FeS/SAM binding site; other site
880072002020	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
880072002021	DsrC like protein; Region: DsrC; pfam04358
880072002022	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
880072002023	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
880072002024	Cysteine-rich domain; Region: CCG; pfam02754
880072002025	Cysteine-rich domain; Region: CCG; pfam02754
880072002026	FAD binding domain; Region: FAD_binding_4; pfam01565
880072002027	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
880072002028	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
880072002029	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
880072002030	metal-binding site [ion binding]
880072002031	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
880072002032	Soluble P-type ATPase [General function prediction only]; Region: COG4087
880072002033	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
880072002034	HlyD family secretion protein; Region: HlyD_3; pfam13437
880072002035	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
880072002036	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
880072002037	Walker A/P-loop; other site
880072002038	ATP binding site [chemical binding]; other site
880072002039	Q-loop/lid; other site
880072002040	ABC transporter signature motif; other site
880072002041	Walker B; other site
880072002042	D-loop; other site
880072002043	H-loop/switch region; other site
880072002044	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
880072002045	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
880072002046	FtsX-like permease family; Region: FtsX; pfam02687
880072002047	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
880072002048	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
880072002049	FtsX-like permease family; Region: FtsX; pfam02687
880072002050	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
880072002051	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
880072002052	hinge; other site
880072002053	active site
880072002054	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
880072002055	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
880072002056	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
880072002057	shikimate binding site; other site
880072002058	NAD(P) binding site [chemical binding]; other site
880072002059	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
880072002060	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
880072002061	active site
880072002062	catalytic residue [active]
880072002063	dimer interface [polypeptide binding]; other site
880072002064	Chorismate mutase type II; Region: CM_2; smart00830
880072002065	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
880072002066	Prephenate dehydratase; Region: PDT; pfam00800
880072002067	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
880072002068	putative L-Phe binding site [chemical binding]; other site
880072002069	Predicted alternative 3-dehydroquinate synthase [Amino acid transport and metabolism]; Region: COG1465
880072002070	3-dehydroquinate synthase; Provisional; Region: PRK02290
880072002071	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
880072002072	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
880072002073	putative active site; other site
880072002074	catalytic residue [active]
880072002075	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
880072002076	Protein of unknown function (DUF1640); Region: DUF1640; pfam07798
880072002077	primosome assembly protein PriA; Validated; Region: PRK05580
880072002078	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
880072002079	ATP binding site [chemical binding]; other site
880072002080	putative Mg++ binding site [ion binding]; other site
880072002081	helicase superfamily c-terminal domain; Region: HELICc; smart00490
880072002082	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
880072002083	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
880072002084	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
880072002085	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
880072002086	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
880072002087	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
880072002088	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
880072002089	active site
880072002090	Methyltransferase domain; Region: Methyltransf_23; pfam13489
880072002091	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072002092	S-adenosylmethionine binding site [chemical binding]; other site
880072002093	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
880072002094	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
880072002095	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
880072002096	Walker A/P-loop; other site
880072002097	ATP binding site [chemical binding]; other site
880072002098	Q-loop/lid; other site
880072002099	ABC transporter signature motif; other site
880072002100	Walker B; other site
880072002101	D-loop; other site
880072002102	H-loop/switch region; other site
880072002103	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
880072002104	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
880072002105	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
880072002106	Walker A/P-loop; other site
880072002107	ATP binding site [chemical binding]; other site
880072002108	Q-loop/lid; other site
880072002109	ABC transporter signature motif; other site
880072002110	Walker B; other site
880072002111	D-loop; other site
880072002112	H-loop/switch region; other site
880072002113	siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718
880072002114	muropeptide transporter; Validated; Region: ampG; cl17669
880072002115	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
880072002116	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
880072002117	N-terminal plug; other site
880072002118	ligand-binding site [chemical binding]; other site
880072002119	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
880072002120	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
880072002121	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
880072002122	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
880072002123	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
880072002124	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
880072002125	Cysteine-rich domain; Region: CCG; pfam02754
880072002126	Cysteine-rich domain; Region: CCG; pfam02754
880072002127	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
880072002128	4Fe-4S binding domain; Region: Fer4; pfam00037
880072002129	glutamate synthase (NADPH), homotetrameric; Region: gltA; TIGR01316
880072002130	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
880072002131	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
880072002132	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
880072002133	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
880072002134	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
880072002135	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
880072002136	Alkaline phosphatase homologues; Region: alkPPc; smart00098
880072002137	active site
880072002138	dimer interface [polypeptide binding]; other site
880072002139	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
880072002140	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
880072002141	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
880072002142	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
880072002143	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
880072002144	active site
880072002145	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
880072002146	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
880072002147	putative NAD(P) binding site [chemical binding]; other site
880072002148	putative active site [active]
880072002149	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
880072002150	NAD synthetase; Provisional; Region: PRK13981
880072002151	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
880072002152	multimer interface [polypeptide binding]; other site
880072002153	active site
880072002154	catalytic triad [active]
880072002155	protein interface 1 [polypeptide binding]; other site
880072002156	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
880072002157	homodimer interface [polypeptide binding]; other site
880072002158	NAD binding pocket [chemical binding]; other site
880072002159	ATP binding pocket [chemical binding]; other site
880072002160	Mg binding site [ion binding]; other site
880072002161	active-site loop [active]
880072002162	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
880072002163	transcription termination factor Rho; Provisional; Region: rho; PRK09376
880072002164	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
880072002165	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
880072002166	RNA binding site [nucleotide binding]; other site
880072002167	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
880072002168	multimer interface [polypeptide binding]; other site
880072002169	Walker A motif; other site
880072002170	ATP binding site [chemical binding]; other site
880072002171	Walker B motif; other site
880072002172	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
880072002173	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
880072002174	CoA-binding site [chemical binding]; other site
880072002175	ATP-binding [chemical binding]; other site
880072002176	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
880072002177	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
880072002178	RNA binding surface [nucleotide binding]; other site
880072002179	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
880072002180	active site
880072002181	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
880072002182	putative active site [active]
880072002183	TRAM domain; Region: TRAM; cl01282
880072002184	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
880072002185	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
880072002186	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
880072002187	generic binding surface II; other site
880072002188	generic binding surface I; other site
880072002189	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
880072002190	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
880072002191	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
880072002192	substrate binding pocket [chemical binding]; other site
880072002193	chain length determination region; other site
880072002194	substrate-Mg2+ binding site; other site
880072002195	catalytic residues [active]
880072002196	aspartate-rich region 1; other site
880072002197	active site lid residues [active]
880072002198	aspartate-rich region 2; other site
880072002199	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
880072002200	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
880072002201	TPP-binding site; other site
880072002202	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
880072002203	PYR/PP interface [polypeptide binding]; other site
880072002204	dimer interface [polypeptide binding]; other site
880072002205	TPP binding site [chemical binding]; other site
880072002206	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
880072002207	Cna protein B-type domain; Region: Cna_B_2; pfam13715
880072002208	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072002209	TPR motif; other site
880072002210	binding surface
880072002211	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
880072002212	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
880072002213	Family of unknown function (DUF490); Region: DUF490; pfam04357
880072002214	Domain of unknown function (DUF3842); Region: DUF3842; pfam12953
880072002215	Predicted RNA-binding protein; Region: RNA_bind_2; pfam10133
880072002216	Methyltransferase domain; Region: Methyltransf_26; pfam13659
880072002217	Class I aldolases; Region: Aldolase_Class_I; cl17187
880072002218	catalytic residue [active]
880072002219	Cytochrome c; Region: Cytochrom_C; pfam00034
880072002220	Uncharacterized conserved protein [Function unknown]; Region: COG1751
880072002221	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
880072002222	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
880072002223	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
880072002224	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
880072002225	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
880072002226	Response regulator receiver domain; Region: Response_reg; pfam00072
880072002227	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072002228	active site
880072002229	phosphorylation site [posttranslational modification]
880072002230	intermolecular recognition site; other site
880072002231	dimerization interface [polypeptide binding]; other site
880072002232	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072002233	dimer interface [polypeptide binding]; other site
880072002234	phosphorylation site [posttranslational modification]
880072002235	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072002236	ATP binding site [chemical binding]; other site
880072002237	Mg2+ binding site [ion binding]; other site
880072002238	G-X-G motif; other site
880072002239	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
880072002240	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
880072002241	ligand binding site [chemical binding]; other site
880072002242	flexible hinge region; other site
880072002243	Ion channel; Region: Ion_trans_2; pfam07885
880072002244	TrkA-N domain; Region: TrkA_N; pfam02254
880072002245	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
880072002246	active site
880072002247	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
880072002248	heme-binding residues [chemical binding]; other site
880072002249	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
880072002250	active site
880072002251	DNA polymerase II large subunit; Validated; Region: PRK04023
880072002252	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
880072002253	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
880072002254	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
880072002255	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072002256	dimer interface [polypeptide binding]; other site
880072002257	phosphorylation site [posttranslational modification]
880072002258	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072002259	ATP binding site [chemical binding]; other site
880072002260	Mg2+ binding site [ion binding]; other site
880072002261	G-X-G motif; other site
880072002262	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
880072002263	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
880072002264	dimerization interface [polypeptide binding]; other site
880072002265	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072002266	putative active site [active]
880072002267	heme pocket [chemical binding]; other site
880072002268	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072002269	dimer interface [polypeptide binding]; other site
880072002270	phosphorylation site [posttranslational modification]
880072002271	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072002272	ATP binding site [chemical binding]; other site
880072002273	Mg2+ binding site [ion binding]; other site
880072002274	G-X-G motif; other site
880072002275	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
880072002276	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072002277	active site
880072002278	phosphorylation site [posttranslational modification]
880072002279	intermolecular recognition site; other site
880072002280	dimerization interface [polypeptide binding]; other site
880072002281	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072002282	Walker A motif; other site
880072002283	ATP binding site [chemical binding]; other site
880072002284	Walker B motif; other site
880072002285	arginine finger; other site
880072002286	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
880072002287	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072002288	active site
880072002289	phosphorylation site [posttranslational modification]
880072002290	intermolecular recognition site; other site
880072002291	dimerization interface [polypeptide binding]; other site
880072002292	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072002293	Walker A motif; other site
880072002294	ATP binding site [chemical binding]; other site
880072002295	Walker B motif; other site
880072002296	arginine finger; other site
880072002297	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
880072002298	AAA domain; Region: AAA_23; pfam13476
880072002299	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
880072002300	Walker A/P-loop; other site
880072002301	ATP binding site [chemical binding]; other site
880072002302	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
880072002303	ABC transporter signature motif; other site
880072002304	Walker B; other site
880072002305	D-loop; other site
880072002306	H-loop/switch region; other site
880072002307	Divergent AAA domain; Region: AAA_4; pfam04326
880072002308	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
880072002309	agmatinase; Region: agmatinase; TIGR01230
880072002310	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
880072002311	putative active site [active]
880072002312	Mn binding site [ion binding]; other site
880072002313	Deoxyhypusine synthase; Region: DS; cl00826
880072002314	deoxyhypusine synthase; Region: dhys; TIGR00321
880072002315	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
880072002316	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
880072002317	catalytic residues [active]
880072002318	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
880072002319	FOG: CBS domain [General function prediction only]; Region: COG0517
880072002320	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
880072002321	Uncharacterized conserved protein [Function unknown]; Region: COG0062
880072002322	putative carbohydrate kinase; Provisional; Region: PRK10565
880072002323	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
880072002324	putative substrate binding site [chemical binding]; other site
880072002325	putative ATP binding site [chemical binding]; other site
880072002326	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
880072002327	tricarballylate utilization protein B; Provisional; Region: PRK15033
880072002328	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
880072002329	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
880072002330	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
880072002331	Domain of unknown function (DUF4309); Region: DUF4309; pfam14172
880072002332	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
880072002333	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
880072002334	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
880072002335	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
880072002336	4Fe-4S binding domain; Region: Fer4; pfam00037
880072002337	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
880072002338	adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854
880072002339	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
880072002340	adenosine phosphosulphate reductase, beta subunit; Region: aprB; TIGR02060
880072002341	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
880072002342	Adenosine-5'-phosphosulfate reductase beta subunit; Region: APS-reductase_C; pfam12139
880072002343	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
880072002344	ATP-sulfurylase; Region: ATPS; cd00517
880072002345	active site
880072002346	HXXH motif; other site
880072002347	flexible loop; other site
880072002348	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
880072002349	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
880072002350	pyridoxal 5'-phosphate binding site [chemical binding]; other site
880072002351	catalytic residue [active]
880072002352	Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951
880072002353	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
880072002354	hypothetical protein; Reviewed; Region: PRK09588
880072002355	signal recognition particle protein; Provisional; Region: PRK10867
880072002356	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
880072002357	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
880072002358	P loop; other site
880072002359	GTP binding site [chemical binding]; other site
880072002360	Signal peptide binding domain; Region: SRP_SPB; pfam02978
880072002361	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
880072002362	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
880072002363	hypothetical protein; Provisional; Region: PRK00468
880072002364	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
880072002365	RimM N-terminal domain; Region: RimM; pfam01782
880072002366	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
880072002367	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
880072002368	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
880072002369	RNA/DNA hybrid binding site [nucleotide binding]; other site
880072002370	active site
880072002371	hypothetical protein; Reviewed; Region: PRK12497
880072002372	Predicted methyltransferases [General function prediction only]; Region: COG0313
880072002373	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
880072002374	putative SAM binding site [chemical binding]; other site
880072002375	putative homodimer interface [polypeptide binding]; other site
880072002376	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
880072002377	regulatory protein interface [polypeptide binding]; other site
880072002378	active site
880072002379	regulatory phosphorylation site [posttranslational modification]; other site
880072002380	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
880072002381	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
880072002382	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
880072002383	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
880072002384	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
880072002385	SmpB-tmRNA interface; other site
880072002386	Predicted helicase [General function prediction only]; Region: COG4889
880072002387	Flagellin N-methylase; Region: FliB; pfam03692
880072002388	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
880072002389	Na binding site [ion binding]; other site
880072002390	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
880072002391	GAF domain; Region: GAF; pfam01590
880072002392	GAF domain; Region: GAF_2; pfam13185
880072002393	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
880072002394	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072002395	putative active site [active]
880072002396	heme pocket [chemical binding]; other site
880072002397	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072002398	dimer interface [polypeptide binding]; other site
880072002399	phosphorylation site [posttranslational modification]
880072002400	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072002401	ATP binding site [chemical binding]; other site
880072002402	Mg2+ binding site [ion binding]; other site
880072002403	G-X-G motif; other site
880072002404	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
880072002405	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
880072002406	pyridoxal 5'-phosphate binding site [chemical binding]; other site
880072002407	homodimer interface [polypeptide binding]; other site
880072002408	catalytic residue [active]
880072002409	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
880072002410	putative active site [active]
880072002411	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
880072002412	bile acid transporter; Region: bass; TIGR00841
880072002413	Sodium Bile acid symporter family; Region: SBF; cl17470
880072002414	4Fe-4S binding domain; Region: Fer4; pfam00037
880072002415	Ferredoxin [Energy production and conversion]; Region: COG1146
880072002416	4Fe-4S binding domain; Region: Fer4; pfam00037
880072002417	Protein of unknown function DUF126; Region: DUF126; pfam01989
880072002418	substrate binding site [chemical binding]; other site
880072002419	Predicted aconitase [General function prediction only]; Region: COG1679
880072002420	Protein of unknown function (DUF521); Region: DUF521; pfam04412
880072002421	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
880072002422	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072002423	Walker A motif; other site
880072002424	ATP binding site [chemical binding]; other site
880072002425	Walker B motif; other site
880072002426	arginine finger; other site
880072002427	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
880072002428	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
880072002429	four helix bundle protein; Region: TIGR02436
880072002430	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
880072002431	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
880072002432	N-acetyl-D-glucosamine binding site [chemical binding]; other site
880072002433	catalytic residue [active]
880072002434	Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563
880072002435	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
880072002436	Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775
880072002437	Tetratricopeptide repeat; Region: TPR_16; pfam13432
880072002438	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072002439	binding surface
880072002440	TPR repeat; Region: TPR_11; pfam13414
880072002441	TPR motif; other site
880072002442	TPR repeat; Region: TPR_11; pfam13414
880072002443	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072002444	binding surface
880072002445	TPR motif; other site
880072002446	Tetratricopeptide repeat; Region: TPR_12; pfam13424
880072002447	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
880072002448	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
880072002449	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
880072002450	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
880072002451	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
880072002452	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
880072002453	ATP binding site [chemical binding]; other site
880072002454	Walker A motif; other site
880072002455	hexamer interface [polypeptide binding]; other site
880072002456	Walker B motif; other site
880072002457	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
880072002458	active site
880072002459	dimerization interface [polypeptide binding]; other site
880072002460	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
880072002461	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
880072002462	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
880072002463	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
880072002464	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
880072002465	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
880072002466	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
880072002467	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
880072002468	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
880072002469	TadE-like protein; Region: TadE; pfam07811
880072002470	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
880072002471	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
880072002472	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
880072002473	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
880072002474	ligand binding site [chemical binding]; other site
880072002475	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
880072002476	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
880072002477	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
880072002478	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
880072002479	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
880072002480	N-acetyl-D-glucosamine binding site [chemical binding]; other site
880072002481	catalytic residue [active]
880072002482	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
880072002483	type II secretion system protein E; Region: type_II_gspE; TIGR02533
880072002484	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
880072002485	Walker A motif; other site
880072002486	ATP binding site [chemical binding]; other site
880072002487	Walker B motif; other site
880072002488	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
880072002489	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
880072002490	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
880072002491	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
880072002492	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
880072002493	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
880072002494	Type II transport protein GspH; Region: GspH; pfam12019
880072002495	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
880072002496	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
880072002497	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
880072002498	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
880072002499	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
880072002500	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
880072002501	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
880072002502	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
880072002503	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
880072002504	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
880072002505	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
880072002506	Protein of unknown function (DUF1640); Region: DUF1640; pfam07798
880072002507	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
880072002508	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
880072002509	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
880072002510	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
880072002511	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
880072002512	putative acyl-acceptor binding pocket; other site
880072002513	PEP-CTERM motif; Region: VPEP; pfam07589
880072002514	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
880072002515	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
880072002516	MarR family; Region: MarR_2; pfam12802
880072002517	MarR family; Region: MarR_2; cl17246
880072002518	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
880072002519	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
880072002520	Cysteine-rich domain; Region: CCG; pfam02754
880072002521	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
880072002522	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
880072002523	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
880072002524	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
880072002525	Ferredoxin [Energy production and conversion]; Region: COG1146
880072002526	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
880072002527	FAD binding site [chemical binding]; other site
880072002528	Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225
880072002529	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
880072002530	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
880072002531	NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493
880072002532	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
880072002533	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
880072002534	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
880072002535	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
880072002536	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
880072002537	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
880072002538	Cysteine-rich domain; Region: CCG; pfam02754
880072002539	Cysteine-rich domain; Region: CCG; pfam02754
880072002540	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
880072002541	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
880072002542	Cysteine-rich domain; Region: CCG; pfam02754
880072002543	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
880072002544	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072002545	active site
880072002546	phosphorylation site [posttranslational modification]
880072002547	intermolecular recognition site; other site
880072002548	dimerization interface [polypeptide binding]; other site
880072002549	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072002550	Walker A motif; other site
880072002551	ATP binding site [chemical binding]; other site
880072002552	Walker B motif; other site
880072002553	arginine finger; other site
880072002554	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
880072002555	Response regulator receiver domain; Region: Response_reg; pfam00072
880072002556	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072002557	active site
880072002558	phosphorylation site [posttranslational modification]
880072002559	intermolecular recognition site; other site
880072002560	dimerization interface [polypeptide binding]; other site
880072002561	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
880072002562	PAS domain; Region: PAS; smart00091
880072002563	putative active site [active]
880072002564	heme pocket [chemical binding]; other site
880072002565	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072002566	dimer interface [polypeptide binding]; other site
880072002567	phosphorylation site [posttranslational modification]
880072002568	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072002569	ATP binding site [chemical binding]; other site
880072002570	Mg2+ binding site [ion binding]; other site
880072002571	G-X-G motif; other site
880072002572	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
880072002573	Response regulator receiver domain; Region: Response_reg; pfam00072
880072002574	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072002575	active site
880072002576	phosphorylation site [posttranslational modification]
880072002577	intermolecular recognition site; other site
880072002578	dimerization interface [polypeptide binding]; other site
880072002579	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
880072002580	FAD binding site [chemical binding]; other site
880072002581	Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225
880072002582	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
880072002583	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
880072002584	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
880072002585	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
880072002586	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
880072002587	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
880072002588	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
880072002589	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
880072002590	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
880072002591	putative DNA binding site [nucleotide binding]; other site
880072002592	putative Zn2+ binding site [ion binding]; other site
880072002593	4Fe-4S binding domain; Region: Fer4; pfam00037
880072002594	Ferredoxin [Energy production and conversion]; Region: COG1146
880072002595	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
880072002596	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
880072002597	4Fe-4S binding domain; Region: Fer4; pfam00037
880072002598	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
880072002599	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
880072002600	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
880072002601	FAD binding site [chemical binding]; other site
880072002602	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072002603	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
880072002604	active site
880072002605	phosphorylation site [posttranslational modification]
880072002606	intermolecular recognition site; other site
880072002607	dimerization interface [polypeptide binding]; other site
880072002608	Patatin-like phospholipase; Region: Patatin; pfam01734
880072002609	active site
880072002610	nucleophile elbow; other site
880072002611	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
880072002612	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
880072002613	catalytic site [active]
880072002614	G-X2-G-X-G-K; other site
880072002615	hypothetical protein; Provisional; Region: PRK04323
880072002616	hypothetical protein; Provisional; Region: PRK11820
880072002617	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
880072002618	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
880072002619	Domain of unknown function (DUF4416); Region: DUF4416; pfam14385
880072002620	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
880072002621	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
880072002622	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
880072002623	pyridoxal 5'-phosphate binding site [chemical binding]; other site
880072002624	homodimer interface [polypeptide binding]; other site
880072002625	catalytic residue [active]
880072002626	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
880072002627	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
880072002628	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
880072002629	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
880072002630	trmE is a tRNA modification GTPase; Region: trmE; cd04164
880072002631	G1 box; other site
880072002632	GTP/Mg2+ binding site [chemical binding]; other site
880072002633	Switch I region; other site
880072002634	G2 box; other site
880072002635	Switch II region; other site
880072002636	G3 box; other site
880072002637	G4 box; other site
880072002638	G5 box; other site
880072002639	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
880072002640	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
880072002641	G-X-X-G motif; other site
880072002642	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
880072002643	RxxxH motif; other site
880072002644	membrane protein insertase; Provisional; Region: PRK01318
880072002645	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
880072002646	Haemolytic domain; Region: Haemolytic; pfam01809
880072002647	Ribonuclease P; Region: Ribonuclease_P; pfam00825
880072002648	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
880072002649	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
880072002650	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
880072002651	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
880072002652	FeS/SAM binding site; other site
880072002653	TRAM domain; Region: TRAM; pfam01938
880072002654	Bifunctional nuclease; Region: DNase-RNase; pfam02577
880072002655	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
880072002656	active site
880072002657	hypothetical protein; Provisional; Region: PRK06361
880072002658	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
880072002659	homotrimer interaction site [polypeptide binding]; other site
880072002660	putative active site [active]
880072002661	Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596
880072002662	Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881
880072002663	Iron-sulfur protein interface; other site
880072002664	proximal heme binding site [chemical binding]; other site
880072002665	fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626
880072002666	L-aspartate oxidase; Provisional; Region: PRK06175
880072002667	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
880072002668	fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552
880072002669	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
880072002670	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
880072002671	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072002672	active site
880072002673	phosphorylation site [posttranslational modification]
880072002674	intermolecular recognition site; other site
880072002675	dimerization interface [polypeptide binding]; other site
880072002676	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
880072002677	DNA binding residues [nucleotide binding]
880072002678	dimerization interface [polypeptide binding]; other site
880072002679	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
880072002680	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072002681	putative active site [active]
880072002682	heme pocket [chemical binding]; other site
880072002683	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
880072002684	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072002685	putative active site [active]
880072002686	heme pocket [chemical binding]; other site
880072002687	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072002688	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
880072002689	putative active site [active]
880072002690	heme pocket [chemical binding]; other site
880072002691	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
880072002692	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072002693	putative active site [active]
880072002694	heme pocket [chemical binding]; other site
880072002695	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072002696	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
880072002697	putative active site [active]
880072002698	heme pocket [chemical binding]; other site
880072002699	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
880072002700	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072002701	putative active site [active]
880072002702	heme pocket [chemical binding]; other site
880072002703	Histidine kinase; Region: HisKA_3; pfam07730
880072002704	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072002705	ATP binding site [chemical binding]; other site
880072002706	Mg2+ binding site [ion binding]; other site
880072002707	G-X-G motif; other site
880072002708	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
880072002709	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
880072002710	motif II; other site
880072002711	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
880072002712	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
880072002713	hinge; other site
880072002714	active site
880072002715	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
880072002716	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
880072002717	ligand binding site [chemical binding]; other site
880072002718	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
880072002719	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
880072002720	TM-ABC transporter signature motif; other site
880072002721	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
880072002722	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
880072002723	TM-ABC transporter signature motif; other site
880072002724	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
880072002725	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
880072002726	Walker A/P-loop; other site
880072002727	ATP binding site [chemical binding]; other site
880072002728	Q-loop/lid; other site
880072002729	ABC transporter signature motif; other site
880072002730	Walker B; other site
880072002731	D-loop; other site
880072002732	H-loop/switch region; other site
880072002733	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
880072002734	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
880072002735	Walker A/P-loop; other site
880072002736	ATP binding site [chemical binding]; other site
880072002737	Q-loop/lid; other site
880072002738	ABC transporter signature motif; other site
880072002739	Walker B; other site
880072002740	D-loop; other site
880072002741	H-loop/switch region; other site
880072002742	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
880072002743	mce related protein; Region: MCE; pfam02470
880072002744	Transposase [DNA replication, recombination, and repair]; Region: COG5421
880072002745	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
880072002746	non-specific DNA binding site [nucleotide binding]; other site
880072002747	Predicted transcriptional regulator [Transcription]; Region: COG2932
880072002748	salt bridge; other site
880072002749	sequence-specific DNA binding site [nucleotide binding]; other site
880072002750	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
880072002751	Catalytic site [active]
880072002752	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
880072002753	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072002754	Walker A motif; other site
880072002755	ATP binding site [chemical binding]; other site
880072002756	Walker B motif; other site
880072002757	arginine finger; other site
880072002758	McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737
880072002759	Helix-turn-helix domain; Region: HTH_17; cl17695
880072002760	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
880072002761	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
880072002762	active site
880072002763	DNA binding site [nucleotide binding]
880072002764	Int/Topo IB signature motif; other site
880072002765	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
880072002766	Orotidine 5'-phosphate decarboxylase / HUMPS family; Region: OMPdecase; smart00934
880072002767	phosphate binding site [ion binding]; other site
880072002768	WYL domain; Region: WYL; pfam13280
880072002769	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
880072002770	putative active site [active]
880072002771	catalytic site [active]
880072002772	Domain of unknown function DUF87; Region: DUF87; pfam01935
880072002773	AAA-like domain; Region: AAA_10; pfam12846
880072002774	Methyltransferase domain; Region: Methyltransf_26; pfam13659
880072002775	Uncharacterized conserved protein [Function unknown]; Region: COG1479
880072002776	Protein of unknown function DUF262; Region: DUF262; pfam03235
880072002777	rod shape-determining protein MreC; Provisional; Region: PRK13922
880072002778	putative transposase OrfB; Reviewed; Region: PHA02517
880072002779	Integrase core domain; Region: rve; pfam00665
880072002780	Integrase core domain; Region: rve_3; pfam13683
880072002781	Fic family protein [Function unknown]; Region: COG3177
880072002782	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
880072002783	Fic/DOC family; Region: Fic; pfam02661
880072002784	HsdM N-terminal domain; Region: HsdM_N; pfam12161
880072002785	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
880072002786	Methyltransferase domain; Region: Methyltransf_26; pfam13659
880072002787	Transposase [DNA replication, recombination, and repair]; Region: COG5421
880072002788	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
880072002789	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
880072002790	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
880072002791	30S subunit binding site; other site
880072002792	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
880072002793	DNA-binding site [nucleotide binding]; DNA binding site
880072002794	RNA-binding motif; other site
880072002795	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
880072002796	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
880072002797	FeS/SAM binding site; other site
880072002798	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
880072002799	4Fe-4S binding domain; Region: Fer4; pfam00037
880072002800	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
880072002801	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
880072002802	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
880072002803	4Fe-4S binding domain; Region: Fer4; pfam00037
880072002804	4Fe-4S binding domain; Region: Fer4; pfam00037
880072002805	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
880072002806	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
880072002807	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
880072002808	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
880072002809	Ferredoxin [Energy production and conversion]; Region: COG1146
880072002810	selenocysteine synthase; Provisional; Region: PRK04311
880072002811	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
880072002812	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
880072002813	catalytic residue [active]
880072002814	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
880072002815	Phosphotransferase enzyme family; Region: APH; pfam01636
880072002816	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
880072002817	dimer interface [polypeptide binding]; other site
880072002818	catalytic triad [active]
880072002819	peroxidatic and resolving cysteines [active]
880072002820	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
880072002821	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
880072002822	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
880072002823	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
880072002824	active site
880072002825	dimer interface [polypeptide binding]; other site
880072002826	metal binding site [ion binding]; metal-binding site
880072002827	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
880072002828	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
880072002829	Cl- selectivity filter; other site
880072002830	Cl- binding residues [ion binding]; other site
880072002831	pore gating glutamate residue; other site
880072002832	dimer interface [polypeptide binding]; other site
880072002833	FOG: CBS domain [General function prediction only]; Region: COG0517
880072002834	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613
880072002835	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
880072002836	dimer interface [polypeptide binding]; other site
880072002837	active site
880072002838	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
880072002839	Ligand Binding Site [chemical binding]; other site
880072002840	Molecular Tunnel; other site
880072002841	Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471
880072002842	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
880072002843	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
880072002844	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
880072002845	active site
880072002846	metal-binding site [ion binding]
880072002847	nucleotide-binding site [chemical binding]; other site
880072002848	threonine dehydratase; Provisional; Region: PRK08198
880072002849	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
880072002850	tetramer interface [polypeptide binding]; other site
880072002851	pyridoxal 5'-phosphate binding site [chemical binding]; other site
880072002852	catalytic residue [active]
880072002853	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
880072002854	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
880072002855	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
880072002856	active site 1 [active]
880072002857	active site 2 [active]
880072002858	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
880072002859	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
880072002860	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
880072002861	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK12461
880072002862	active site
880072002863	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
880072002864	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
880072002865	putative metal binding site; other site
880072002866	Trm112p-like protein; Region: Trm112p; cl01066
880072002867	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
880072002868	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
880072002869	putative active site [active]
880072002870	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
880072002871	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
880072002872	active site
880072002873	motif I; other site
880072002874	motif II; other site
880072002875	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
880072002876	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
880072002877	putative active site [active]
880072002878	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
880072002879	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
880072002880	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
880072002881	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
880072002882	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
880072002883	Walker A/P-loop; other site
880072002884	ATP binding site [chemical binding]; other site
880072002885	Q-loop/lid; other site
880072002886	ABC transporter signature motif; other site
880072002887	Walker B; other site
880072002888	D-loop; other site
880072002889	H-loop/switch region; other site
880072002890	Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191
880072002891	FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663
880072002892	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
880072002893	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
880072002894	putative ADP-ribose binding site [chemical binding]; other site
880072002895	putative active site [active]
880072002896	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
880072002897	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
880072002898	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
880072002899	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
880072002900	nudix motif; other site
880072002901	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
880072002902	Peptidase family M50; Region: Peptidase_M50; pfam02163
880072002903	active site
880072002904	putative substrate binding region [chemical binding]; other site
880072002905	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
880072002906	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
880072002907	RNA binding surface [nucleotide binding]; other site
880072002908	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
880072002909	active site
880072002910	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
880072002911	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
880072002912	active site
880072002913	HIGH motif; other site
880072002914	dimer interface [polypeptide binding]; other site
880072002915	KMSKS motif; other site
880072002916	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
880072002917	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
880072002918	DNA-binding site [nucleotide binding]; DNA binding site
880072002919	RNA-binding motif; other site
880072002920	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
880072002921	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
880072002922	Metal-binding active site; metal-binding site
880072002923	AP (apurinic/apyrimidinic) site pocket; other site
880072002924	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
880072002925	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
880072002926	dimer interface [polypeptide binding]; other site
880072002927	substrate binding site [chemical binding]; other site
880072002928	metal binding site [ion binding]; metal-binding site
880072002929	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
880072002930	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
880072002931	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
880072002932	ATP binding site [chemical binding]; other site
880072002933	putative Mg++ binding site [ion binding]; other site
880072002934	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
880072002935	nucleotide binding region [chemical binding]; other site
880072002936	ATP-binding site [chemical binding]; other site
880072002937	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
880072002938	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
880072002939	SurA N-terminal domain; Region: SurA_N; pfam09312
880072002940	PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616
880072002941	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
880072002942	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
880072002943	putative dimer interface [polypeptide binding]; other site
880072002944	putative anticodon binding site; other site
880072002945	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
880072002946	homodimer interface [polypeptide binding]; other site
880072002947	motif 1; other site
880072002948	motif 2; other site
880072002949	active site
880072002950	motif 3; other site
880072002951	Predicted helicase [General function prediction only]; Region: COG4889
880072002952	peptide chain release factor 2; Validated; Region: prfB; PRK00578
880072002953	This domain is found in peptide chain release factors; Region: PCRF; smart00937
880072002954	RF-1 domain; Region: RF-1; pfam00472
880072002955	FeoA domain; Region: FeoA; pfam04023
880072002956	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
880072002957	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
880072002958	Soluble P-type ATPase [General function prediction only]; Region: COG4087
880072002959	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
880072002960	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
880072002961	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
880072002962	Soluble P-type ATPase [General function prediction only]; Region: COG4087
880072002963	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
880072002964	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
880072002965	G1 box; other site
880072002966	GTP/Mg2+ binding site [chemical binding]; other site
880072002967	Switch I region; other site
880072002968	G2 box; other site
880072002969	G3 box; other site
880072002970	Switch II region; other site
880072002971	G4 box; other site
880072002972	G5 box; other site
880072002973	Nucleoside recognition; Region: Gate; pfam07670
880072002974	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
880072002975	Nucleoside recognition; Region: Gate; pfam07670
880072002976	FeoA domain; Region: FeoA; pfam04023
880072002977	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
880072002978	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
880072002979	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
880072002980	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
880072002981	HlyD family secretion protein; Region: HlyD_2; pfam12700
880072002982	HlyD family secretion protein; Region: HlyD_3; pfam13437
880072002983	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
880072002984	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
880072002985	Walker A/P-loop; other site
880072002986	ATP binding site [chemical binding]; other site
880072002987	Q-loop/lid; other site
880072002988	ABC transporter signature motif; other site
880072002989	Walker B; other site
880072002990	D-loop; other site
880072002991	H-loop/switch region; other site
880072002992	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
880072002993	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
880072002994	FtsX-like permease family; Region: FtsX; pfam02687
880072002995	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
880072002996	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
880072002997	lipoyl attachment site [posttranslational modification]; other site
880072002998	Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cd11375
880072002999	active site
880072003000	Zn binding site [ion binding]; other site
880072003001	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
880072003002	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072003003	active site
880072003004	phosphorylation site [posttranslational modification]
880072003005	intermolecular recognition site; other site
880072003006	dimerization interface [polypeptide binding]; other site
880072003007	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072003008	Walker A motif; other site
880072003009	ATP binding site [chemical binding]; other site
880072003010	Walker B motif; other site
880072003011	arginine finger; other site
880072003012	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
880072003013	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
880072003014	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072003015	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
880072003016	putative active site [active]
880072003017	heme pocket [chemical binding]; other site
880072003018	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
880072003019	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072003020	putative active site [active]
880072003021	heme pocket [chemical binding]; other site
880072003022	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072003023	dimer interface [polypeptide binding]; other site
880072003024	phosphorylation site [posttranslational modification]
880072003025	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072003026	ATP binding site [chemical binding]; other site
880072003027	Mg2+ binding site [ion binding]; other site
880072003028	G-X-G motif; other site
880072003029	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
880072003030	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
880072003031	Walker A motif; other site
880072003032	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
880072003033	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
880072003034	Coenzyme A binding pocket [chemical binding]; other site
880072003035	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
880072003036	metal binding triad [ion binding]; metal-binding site
880072003037	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
880072003038	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
880072003039	GatB domain; Region: GatB_Yqey; smart00845
880072003040	ribulose-1,5-biphosphate synthetase; Provisional; Region: PRK04176
880072003041	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
880072003042	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
880072003043	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
880072003044	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
880072003045	AAA domain; Region: AAA_32; pfam13654
880072003046	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
880072003047	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
880072003048	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072003049	S-adenosylmethionine binding site [chemical binding]; other site
880072003050	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
880072003051	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477
880072003052	nickel binding site [ion binding]; other site
880072003053	hydrogenase nickel insertion protein HypA; Region: hypA; TIGR00100
880072003054	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
880072003055	Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977
880072003056	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
880072003057	catalytic residues [active]
880072003058	Transcriptional regulator [Transcription]; Region: LysR; COG0583
880072003059	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
880072003060	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
880072003061	dimerization interface [polypeptide binding]; other site
880072003062	Predicted thioesterase [General function prediction only]; Region: COG5496
880072003063	Putative Fe-S cluster; Region: FeS; cl17515
880072003064	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
880072003065	AIR carboxylase; Region: AIRC; smart01001
880072003066	hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472
880072003067	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
880072003068	ligand binding site; other site
880072003069	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
880072003070	Serine hydrolase; Region: Ser_hydrolase; cl17834
880072003071	Putative amidase domain; Region: Amidase_6; pfam12671
880072003072	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
880072003073	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
880072003074	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
880072003075	ligand binding site; other site
880072003076	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
880072003077	Serine hydrolase; Region: Ser_hydrolase; cl17834
880072003078	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
880072003079	Major Facilitator Superfamily; Region: MFS_1; pfam07690
880072003080	putative substrate translocation pore; other site
880072003081	glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915
880072003082	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
880072003083	putative acyl-acceptor binding pocket; other site
880072003084	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
880072003085	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
880072003086	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
880072003087	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
880072003088	dimer interface [polypeptide binding]; other site
880072003089	motif 1; other site
880072003090	active site
880072003091	motif 2; other site
880072003092	motif 3; other site
880072003093	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
880072003094	DALR anticodon binding domain; Region: DALR_1; pfam05746
880072003095	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
880072003096	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
880072003097	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
880072003098	P loop; other site
880072003099	GTP binding site [chemical binding]; other site
880072003100	VanZ like family; Region: VanZ; cl01971
880072003101	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
880072003102	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
880072003103	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
880072003104	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
880072003105	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
880072003106	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
880072003107	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
880072003108	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
880072003109	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
880072003110	protein binding site [polypeptide binding]; other site
880072003111	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
880072003112	protein binding site [polypeptide binding]; other site
880072003113	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
880072003114	active site
880072003115	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239
880072003116	domain_subunit interface; other site
880072003117	4Fe-4S binding domain; Region: Fer4; pfam00037
880072003118	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
880072003119	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
880072003120	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
880072003121	active site
880072003122	FMN binding site [chemical binding]; other site
880072003123	substrate binding site [chemical binding]; other site
880072003124	3Fe-4S cluster binding site [ion binding]; other site
880072003125	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
880072003126	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
880072003127	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cd04722
880072003128	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
880072003129	phosphate binding site [ion binding]; other site
880072003130	phosphate binding site [ion binding]; other site
880072003131	Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225
880072003132	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831
880072003133	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
880072003134	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
880072003135	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
880072003136	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
880072003137	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
880072003138	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
880072003139	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
880072003140	catalytic site [active]
880072003141	subunit interface [polypeptide binding]; other site
880072003142	YcfA-like protein; Region: YcfA; cl00752
880072003143	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
880072003144	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
880072003145	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
880072003146	Switch I region; other site
880072003147	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
880072003148	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
880072003149	active site
880072003150	NTP binding site [chemical binding]; other site
880072003151	metal binding triad [ion binding]; metal-binding site
880072003152	HEPN domain; Region: HEPN; pfam05168
880072003153	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
880072003154	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
880072003155	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
880072003156	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
880072003157	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
880072003158	ATP-grasp domain; Region: ATP-grasp_4; cl17255
880072003159	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
880072003160	IMP binding site; other site
880072003161	dimer interface [polypeptide binding]; other site
880072003162	carbon storage regulator; Provisional; Region: PRK01712
880072003163	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
880072003164	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
880072003165	nucleotide binding site [chemical binding]; other site
880072003166	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
880072003167	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
880072003168	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
880072003169	putative dimer interface [polypeptide binding]; other site
880072003170	[2Fe-2S] cluster binding site [ion binding]; other site
880072003171	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
880072003172	SLBB domain; Region: SLBB; pfam10531
880072003173	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
880072003174	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
880072003175	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
880072003176	catalytic loop [active]
880072003177	iron binding site [ion binding]; other site
880072003178	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
880072003179	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
880072003180	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
880072003181	[4Fe-4S] binding site [ion binding]; other site
880072003182	molybdopterin cofactor binding site; other site
880072003183	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
880072003184	molybdopterin cofactor binding site; other site
880072003185	FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663
880072003186	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
880072003187	putative MPT binding site; other site
880072003188	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
880072003189	thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771
880072003190	Walker A/P-loop; other site
880072003191	ATP binding site [chemical binding]; other site
880072003192	Q-loop/lid; other site
880072003193	ABC transporter signature motif; other site
880072003194	Walker B; other site
880072003195	D-loop; other site
880072003196	H-loop/switch region; other site
880072003197	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
880072003198	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
880072003199	dimer interface [polypeptide binding]; other site
880072003200	conserved gate region; other site
880072003201	putative PBP binding loops; other site
880072003202	ABC-ATPase subunit interface; other site
880072003203	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
880072003204	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
880072003205	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
880072003206	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
880072003207	ATP binding site [chemical binding]; other site
880072003208	Mg++ binding site [ion binding]; other site
880072003209	motif III; other site
880072003210	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
880072003211	nucleotide binding region [chemical binding]; other site
880072003212	ATP-binding site [chemical binding]; other site
880072003213	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
880072003214	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
880072003215	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
880072003216	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
880072003217	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
880072003218	DNA-binding site [nucleotide binding]; DNA binding site
880072003219	RNA-binding motif; other site
880072003220	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
880072003221	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
880072003222	putative dimer interface [polypeptide binding]; other site
880072003223	[2Fe-2S] cluster binding site [ion binding]; other site
880072003224	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
880072003225	SLBB domain; Region: SLBB; pfam10531
880072003226	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
880072003227	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
880072003228	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
880072003229	catalytic loop [active]
880072003230	iron binding site [ion binding]; other site
880072003231	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
880072003232	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
880072003233	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
880072003234	[4Fe-4S] binding site [ion binding]; other site
880072003235	molybdopterin cofactor binding site; other site
880072003236	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
880072003237	molybdopterin cofactor binding site; other site
880072003238	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
880072003239	PemK-like protein; Region: PemK; pfam02452
880072003240	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
880072003241	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
880072003242	putative dimer interface [polypeptide binding]; other site
880072003243	[2Fe-2S] cluster binding site [ion binding]; other site
880072003244	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
880072003245	SLBB domain; Region: SLBB; pfam10531
880072003246	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
880072003247	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
880072003248	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
880072003249	catalytic loop [active]
880072003250	iron binding site [ion binding]; other site
880072003251	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
880072003252	4Fe-4S binding domain; Region: Fer4; pfam00037
880072003253	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
880072003254	[4Fe-4S] binding site [ion binding]; other site
880072003255	molybdopterin cofactor binding site; other site
880072003256	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
880072003257	molybdopterin cofactor binding site; other site
880072003258	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
880072003259	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
880072003260	putative dimer interface [polypeptide binding]; other site
880072003261	[2Fe-2S] cluster binding site [ion binding]; other site
880072003262	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
880072003263	SLBB domain; Region: SLBB; pfam10531
880072003264	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
880072003265	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
880072003266	molybdopterin cofactor binding site; other site
880072003267	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
880072003268	molybdopterin cofactor binding site; other site
880072003269	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
880072003270	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
880072003271	catalytic loop [active]
880072003272	iron binding site [ion binding]; other site
880072003273	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
880072003274	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
880072003275	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
880072003276	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
880072003277	Walker A/P-loop; other site
880072003278	ATP binding site [chemical binding]; other site
880072003279	Q-loop/lid; other site
880072003280	ABC transporter signature motif; other site
880072003281	Walker B; other site
880072003282	D-loop; other site
880072003283	H-loop/switch region; other site
880072003284	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
880072003285	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
880072003286	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
880072003287	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
880072003288	DNA binding residues [nucleotide binding]
880072003289	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
880072003290	Walker A motif; other site
880072003291	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
880072003292	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
880072003293	GTP binding site; other site
880072003294	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
880072003295	CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310
880072003296	FOG: CBS domain [General function prediction only]; Region: COG0517
880072003297	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
880072003298	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
880072003299	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
880072003300	N-acetyl-D-glucosamine binding site [chemical binding]; other site
880072003301	catalytic residue [active]
880072003302	Mechanosensitive ion channel; Region: MS_channel; pfam00924
880072003303	Mg2+ transporter (mgtE); Region: mgtE; TIGR00400
880072003304	MgtE intracellular N domain; Region: MgtE_N; smart00924
880072003305	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
880072003306	Divalent cation transporter; Region: MgtE; pfam01769
880072003307	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
880072003308	Ligand Binding Site [chemical binding]; other site
880072003309	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
880072003310	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
880072003311	dimer interface [polypeptide binding]; other site
880072003312	pyridoxal 5'-phosphate binding site [chemical binding]; other site
880072003313	catalytic residue [active]
880072003314	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
880072003315	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
880072003316	active site
880072003317	HIGH motif; other site
880072003318	nucleotide binding site [chemical binding]; other site
880072003319	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
880072003320	KMSKS motif; other site
880072003321	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
880072003322	cobalt transport protein CbiM; Validated; Region: PRK06265
880072003323	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
880072003324	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
880072003325	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
880072003326	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
880072003327	Walker A/P-loop; other site
880072003328	ATP binding site [chemical binding]; other site
880072003329	Q-loop/lid; other site
880072003330	ABC transporter signature motif; other site
880072003331	Walker B; other site
880072003332	D-loop; other site
880072003333	H-loop/switch region; other site
880072003334	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
880072003335	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
880072003336	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
880072003337	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
880072003338	putative active site [active]
880072003339	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
880072003340	formylmethanofuran dehydrogenase subunit B; Region: one_C_dehyd_B; TIGR03129
880072003341	molybdopterin cofactor binding site; other site
880072003342	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
880072003343	Amidohydrolase family; Region: Amidohydro_3; pfam07969
880072003344	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
880072003345	Putative Fe-S cluster; Region: FeS; cl17515
880072003346	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
880072003347	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
880072003348	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
880072003349	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
880072003350	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
880072003351	Protein of unknown function (DUF3795); Region: DUF3795; pfam12675
880072003352	glycogen synthase; Provisional; Region: glgA; PRK00654
880072003353	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
880072003354	ADP-binding pocket [chemical binding]; other site
880072003355	homodimer interface [polypeptide binding]; other site
880072003356	Uncharacterized conserved protein [Function unknown]; Region: COG1432
880072003357	LabA_like proteins; Region: LabA; cd10911
880072003358	putative metal binding site [ion binding]; other site
880072003359	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
880072003360	GrpE; Region: GrpE; pfam01025
880072003361	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
880072003362	dimer interface [polypeptide binding]; other site
880072003363	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
880072003364	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
880072003365	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
880072003366	nucleotide binding site [chemical binding]; other site
880072003367	NEF interaction site [polypeptide binding]; other site
880072003368	SBD interface [polypeptide binding]; other site
880072003369	Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063
880072003370	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072003371	binding surface
880072003372	TPR motif; other site
880072003373	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
880072003374	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
880072003375	ligand binding site [chemical binding]; other site
880072003376	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
880072003377	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
880072003378	cleavage site
880072003379	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
880072003380	ferrous iron transporter FeoB; Region: feoB; TIGR00437
880072003381	G1 box; other site
880072003382	GTP/Mg2+ binding site [chemical binding]; other site
880072003383	Switch I region; other site
880072003384	G2 box; other site
880072003385	G3 box; other site
880072003386	Switch II region; other site
880072003387	G4 box; other site
880072003388	G5 box; other site
880072003389	Nucleoside recognition; Region: Gate; pfam07670
880072003390	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
880072003391	Nucleoside recognition; Region: Gate; pfam07670
880072003392	FeoA domain; Region: FeoA; pfam04023
880072003393	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
880072003394	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
880072003395	oligomer interface [polypeptide binding]; other site
880072003396	active site
880072003397	metal binding site [ion binding]; metal-binding site
880072003398	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
880072003399	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
880072003400	G1 box; other site
880072003401	GTP/Mg2+ binding site [chemical binding]; other site
880072003402	Switch I region; other site
880072003403	G2 box; other site
880072003404	G3 box; other site
880072003405	Switch II region; other site
880072003406	G4 box; other site
880072003407	G5 box; other site
880072003408	hypothetical protein; Provisional; Region: PRK12705
880072003409	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
880072003410	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
880072003411	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
880072003412	FeS/SAM binding site; other site
880072003413	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07187
880072003414	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
880072003415	Ligand Binding Site [chemical binding]; other site
880072003416	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
880072003417	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
880072003418	RNA/DNA hybrid binding site [nucleotide binding]; other site
880072003419	active site
880072003420	Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596
880072003421	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
880072003422	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072003423	PAS domain; Region: PAS_9; pfam13426
880072003424	putative active site [active]
880072003425	heme pocket [chemical binding]; other site
880072003426	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
880072003427	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072003428	Walker A motif; other site
880072003429	ATP binding site [chemical binding]; other site
880072003430	Walker B motif; other site
880072003431	arginine finger; other site
880072003432	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
880072003433	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
880072003434	PAS fold; Region: PAS_4; pfam08448
880072003435	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072003436	dimer interface [polypeptide binding]; other site
880072003437	phosphorylation site [posttranslational modification]
880072003438	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072003439	ATP binding site [chemical binding]; other site
880072003440	Mg2+ binding site [ion binding]; other site
880072003441	G-X-G motif; other site
880072003442	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072003443	active site
880072003444	phosphorylation site [posttranslational modification]
880072003445	intermolecular recognition site; other site
880072003446	dimerization interface [polypeptide binding]; other site
880072003447	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
880072003448	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
880072003449	S-formylglutathione hydrolase; Region: PLN02442
880072003450	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
880072003451	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
880072003452	active site
880072003453	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
880072003454	Protein of unknown function (DUF422); Region: DUF422; cl00991
880072003455	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
880072003456	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
880072003457	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
880072003458	UbiA prenyltransferase family; Region: UbiA; pfam01040
880072003459	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
880072003460	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
880072003461	inhibitor-cofactor binding pocket; inhibition site
880072003462	pyridoxal 5'-phosphate binding site [chemical binding]; other site
880072003463	catalytic residue [active]
880072003464	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
880072003465	NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180
880072003466	NAD binding site [chemical binding]; other site
880072003467	substrate binding site [chemical binding]; other site
880072003468	active site
880072003469	pyruvate phosphate dikinase; Provisional; Region: PRK09279
880072003470	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
880072003471	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
880072003472	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
880072003473	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
880072003474	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
880072003475	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
880072003476	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
880072003477	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
880072003478	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
880072003479	motif II; other site
880072003480	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
880072003481	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
880072003482	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072003483	S-adenosylmethionine binding site [chemical binding]; other site
880072003484	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
880072003485	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072003486	active site
880072003487	phosphorylation site [posttranslational modification]
880072003488	intermolecular recognition site; other site
880072003489	dimerization interface [polypeptide binding]; other site
880072003490	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072003491	Walker A motif; other site
880072003492	ATP binding site [chemical binding]; other site
880072003493	Walker B motif; other site
880072003494	arginine finger; other site
880072003495	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
880072003496	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
880072003497	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
880072003498	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
880072003499	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
880072003500	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
880072003501	putative active site [active]
880072003502	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
880072003503	RNA 2'-phosphotransferase; Reviewed; Region: PRK00819
880072003504	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
880072003505	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cl00182
880072003506	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
880072003507	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
880072003508	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
880072003509	CoA binding domain; Region: CoA_binding_2; pfam13380
880072003510	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
880072003511	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
880072003512	16S rRNA methyltransferase B; Provisional; Region: PRK14902
880072003513	NusB family; Region: NusB; pfam01029
880072003514	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072003515	S-adenosylmethionine binding site [chemical binding]; other site
880072003516	Protein of unknown function DUF116; Region: DUF116; pfam01976
880072003517	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
880072003518	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
880072003519	putative active site [active]
880072003520	substrate binding site [chemical binding]; other site
880072003521	putative cosubstrate binding site; other site
880072003522	catalytic site [active]
880072003523	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
880072003524	substrate binding site [chemical binding]; other site
880072003525	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
880072003526	active site
880072003527	catalytic residues [active]
880072003528	metal binding site [ion binding]; metal-binding site
880072003529	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
880072003530	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
880072003531	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
880072003532	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
880072003533	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
880072003534	tetramer interface [polypeptide binding]; other site
880072003535	heme binding pocket [chemical binding]; other site
880072003536	NADPH binding site [chemical binding]; other site
880072003537	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
880072003538	metal binding site 2 [ion binding]; metal-binding site
880072003539	putative DNA binding helix; other site
880072003540	metal binding site 1 [ion binding]; metal-binding site
880072003541	dimer interface [polypeptide binding]; other site
880072003542	structural Zn2+ binding site [ion binding]; other site
880072003543	DDE superfamily endonuclease; Region: DDE_5; cl17874
880072003544	rod shape-determining protein MreB; Provisional; Region: PRK13927
880072003545	MreB and similar proteins; Region: MreB_like; cd10225
880072003546	nucleotide binding site [chemical binding]; other site
880072003547	Mg binding site [ion binding]; other site
880072003548	putative protofilament interaction site [polypeptide binding]; other site
880072003549	RodZ interaction site [polypeptide binding]; other site
880072003550	rod shape-determining protein MreC; Provisional; Region: PRK13922
880072003551	rod shape-determining protein MreC; Region: MreC; pfam04085
880072003552	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
880072003553	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
880072003554	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
880072003555	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
880072003556	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072003557	S-adenosylmethionine binding site [chemical binding]; other site
880072003558	bifunctional hexulose-6-phosphate synthase/ribonuclease regulator; Validated; Region: PRK07028
880072003559	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
880072003560	active site
880072003561	dimer interface [polypeptide binding]; other site
880072003562	magnesium binding site [ion binding]; other site
880072003563	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
880072003564	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
880072003565	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
880072003566	tetramer interface [polypeptide binding]; other site
880072003567	active site
880072003568	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
880072003569	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
880072003570	plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647
880072003571	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
880072003572	Soluble P-type ATPase [General function prediction only]; Region: COG4087
880072003573	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
880072003574	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
880072003575	active site
880072003576	NTP binding site [chemical binding]; other site
880072003577	metal binding triad [ion binding]; metal-binding site
880072003578	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
880072003579	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
880072003580	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
880072003581	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
880072003582	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
880072003583	acyl-activating enzyme (AAE) consensus motif; other site
880072003584	AMP binding site [chemical binding]; other site
880072003585	active site
880072003586	CoA binding site [chemical binding]; other site
880072003587	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
880072003588	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
880072003589	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
880072003590	metal binding site 2 [ion binding]; metal-binding site
880072003591	putative DNA binding helix; other site
880072003592	metal binding site 1 [ion binding]; metal-binding site
880072003593	dimer interface [polypeptide binding]; other site
880072003594	structural Zn2+ binding site [ion binding]; other site
880072003595	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
880072003596	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
880072003597	dimerization interface [polypeptide binding]; other site
880072003598	active site
880072003599	metal binding site [ion binding]; metal-binding site
880072003600	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
880072003601	dsRNA binding site [nucleotide binding]; other site
880072003602	NlpC/P60 family; Region: NLPC_P60; cl17555
880072003603	Domain of unknown function (DUF3786); Region: DUF3786; pfam12654
880072003604	N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797
880072003605	active site
880072003606	catalytic site [active]
880072003607	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
880072003608	Uncharacterized conserved protein [Function unknown]; Region: COG5663
880072003609	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
880072003610	active site
880072003611	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
880072003612	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
880072003613	N-terminal plug; other site
880072003614	ligand-binding site [chemical binding]; other site
880072003615	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
880072003616	NADH dehydrogenase subunit B; Validated; Region: PRK06411
880072003617	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
880072003618	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
880072003619	NADH dehydrogenase subunit D; Validated; Region: PRK06075
880072003620	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
880072003621	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
880072003622	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
880072003623	4Fe-4S binding domain; Region: Fer4; pfam00037
880072003624	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
880072003625	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
880072003626	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
880072003627	NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NuoL; COG1009
880072003628	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
880072003629	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
880072003630	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
880072003631	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
880072003632	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
880072003633	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
880072003634	Dinitrogenase iron-molybdenum cofactor; Region: Nitro_FeMo-Co; pfam02579
880072003635	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
880072003636	active site
880072003637	trimerization site [polypeptide binding]; other site
880072003638	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072003639	active site
880072003640	phosphorylation site [posttranslational modification]
880072003641	intermolecular recognition site; other site
880072003642	dimerization interface [polypeptide binding]; other site
880072003643	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
880072003644	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
880072003645	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
880072003646	dimerization interface [polypeptide binding]; other site
880072003647	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072003648	dimer interface [polypeptide binding]; other site
880072003649	phosphorylation site [posttranslational modification]
880072003650	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072003651	ATP binding site [chemical binding]; other site
880072003652	Mg2+ binding site [ion binding]; other site
880072003653	G-X-G motif; other site
880072003654	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
880072003655	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072003656	active site
880072003657	phosphorylation site [posttranslational modification]
880072003658	intermolecular recognition site; other site
880072003659	dimerization interface [polypeptide binding]; other site
880072003660	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072003661	Walker A motif; other site
880072003662	ATP binding site [chemical binding]; other site
880072003663	Walker B motif; other site
880072003664	arginine finger; other site
880072003665	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
880072003666	Response regulator receiver domain; Region: Response_reg; pfam00072
880072003667	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072003668	active site
880072003669	phosphorylation site [posttranslational modification]
880072003670	intermolecular recognition site; other site
880072003671	dimerization interface [polypeptide binding]; other site
880072003672	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072003673	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
880072003674	Walker A motif; other site
880072003675	ATP binding site [chemical binding]; other site
880072003676	Walker B motif; other site
880072003677	arginine finger; other site
880072003678	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
880072003679	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
880072003680	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
880072003681	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
880072003682	Ligand Binding Site [chemical binding]; other site
880072003683	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
880072003684	Ligand Binding Site [chemical binding]; other site
880072003685	peptide-modifying radical SAM enzyme CbpB; Region: rSAM_cobopep; TIGR04163
880072003686	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
880072003687	FeS/SAM binding site; other site
880072003688	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
880072003689	modified peptide precursor CbpA; Region: cobo_pep; TIGR04164
880072003690	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
880072003691	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
880072003692	metal binding site [ion binding]; metal-binding site
880072003693	active site
880072003694	I-site; other site
880072003695	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
880072003696	putative active site [active]
880072003697	homotetrameric interface [polypeptide binding]; other site
880072003698	metal binding site [ion binding]; metal-binding site
880072003699	Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910
880072003700	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
880072003701	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
880072003702	N-terminal plug; other site
880072003703	ligand-binding site [chemical binding]; other site
880072003704	Uncharacterized subfamily of S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase_like; cd11724
880072003705	putative SAM binding site [chemical binding]; other site
880072003706	putative homodimer interface [polypeptide binding]; other site
880072003707	MarR family; Region: MarR; pfam01047
880072003708	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
880072003709	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
880072003710	HlyD family secretion protein; Region: HlyD_3; pfam13437
880072003711	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
880072003712	Protein export membrane protein; Region: SecD_SecF; cl14618
880072003713	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
880072003714	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
880072003715	hypothetical protein; Provisional; Region: PRK11622
880072003716	putative fructoselysine transporter; Provisional; Region: frlA; PRK11357
880072003717	Uncharacterized subfamily of S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase_like; cd11724
880072003718	putative SAM binding site [chemical binding]; other site
880072003719	putative homodimer interface [polypeptide binding]; other site
880072003720	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
880072003721	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
880072003722	N-terminal plug; other site
880072003723	ligand-binding site [chemical binding]; other site
880072003724	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
880072003725	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
880072003726	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
880072003727	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
880072003728	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
880072003729	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
880072003730	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
880072003731	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
880072003732	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
880072003733	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
880072003734	putative DNA binding site [nucleotide binding]; other site
880072003735	putative Zn2+ binding site [ion binding]; other site
880072003736	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
880072003737	Glycoprotease family; Region: Peptidase_M22; pfam00814
880072003738	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
880072003739	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
880072003740	TM-ABC transporter signature motif; other site
880072003741	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
880072003742	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
880072003743	TM-ABC transporter signature motif; other site
880072003744	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
880072003745	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
880072003746	Walker A/P-loop; other site
880072003747	ATP binding site [chemical binding]; other site
880072003748	Q-loop/lid; other site
880072003749	ABC transporter signature motif; other site
880072003750	Walker B; other site
880072003751	D-loop; other site
880072003752	H-loop/switch region; other site
880072003753	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
880072003754	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
880072003755	Walker A/P-loop; other site
880072003756	ATP binding site [chemical binding]; other site
880072003757	Q-loop/lid; other site
880072003758	ABC transporter signature motif; other site
880072003759	Walker B; other site
880072003760	D-loop; other site
880072003761	H-loop/switch region; other site
880072003762	Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453
880072003763	active site
880072003764	catalytic residues [active]
880072003765	Flagellin N-methylase; Region: FliB; pfam03692
880072003766	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
880072003767	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
880072003768	putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266
880072003769	YcaO-like family; Region: YcaO; pfam02624
880072003770	Tetratricopeptide repeat; Region: TPR_16; pfam13432
880072003771	TPR repeat; Region: TPR_11; pfam13414
880072003772	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072003773	binding surface
880072003774	TPR motif; other site
880072003775	TPR repeat; Region: TPR_11; pfam13414
880072003776	Predicted GTPase or GTP-binding protein [General function prediction only]; Region: COG1341
880072003777	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
880072003778	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
880072003779	FMN binding site [chemical binding]; other site
880072003780	dimer interface [polypeptide binding]; other site
880072003781	Protein of unknown function (DUF3568); Region: DUF3568; pfam12092
880072003782	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
880072003783	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
880072003784	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
880072003785	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
880072003786	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
880072003787	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
880072003788	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
880072003789	putative active site; other site
880072003790	catalytic residue [active]
880072003791	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
880072003792	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
880072003793	acyl-activating enzyme (AAE) consensus motif; other site
880072003794	AMP binding site [chemical binding]; other site
880072003795	active site
880072003796	CoA binding site [chemical binding]; other site
880072003797	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
880072003798	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072003799	PAS fold; Region: PAS_3; pfam08447
880072003800	putative active site [active]
880072003801	heme pocket [chemical binding]; other site
880072003802	PAS domain S-box; Region: sensory_box; TIGR00229
880072003803	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072003804	putative active site [active]
880072003805	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
880072003806	GAF domain; Region: GAF_3; pfam13492
880072003807	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
880072003808	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
880072003809	metal binding site [ion binding]; metal-binding site
880072003810	active site
880072003811	I-site; other site
880072003812	Predicted permeases [General function prediction only]; Region: COG0730
880072003813	Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; cl09826
880072003814	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
880072003815	Ligand Binding Site [chemical binding]; other site
880072003816	DnaJ domain; Region: DnaJ; pfam00226
880072003817	HSP70 interaction site [polypeptide binding]; other site
880072003818	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
880072003819	Terminase-like family; Region: Terminase_6; pfam03237
880072003820	large terminase protein; Provisional; Region: 17; PHA02533
880072003821	Response regulator receiver domain; Region: Response_reg; pfam00072
880072003822	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072003823	active site
880072003824	phosphorylation site [posttranslational modification]
880072003825	intermolecular recognition site; other site
880072003826	dimerization interface [polypeptide binding]; other site
880072003827	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
880072003828	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
880072003829	metal binding site [ion binding]; metal-binding site
880072003830	active site
880072003831	I-site; other site
880072003832	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
880072003833	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
880072003834	TPP-binding site [chemical binding]; other site
880072003835	dimer interface [polypeptide binding]; other site
880072003836	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
880072003837	PYR/PP interface [polypeptide binding]; other site
880072003838	dimer interface [polypeptide binding]; other site
880072003839	TPP binding site [chemical binding]; other site
880072003840	DNA methylase; Region: N6_N4_Mtase; cl17433
880072003841	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
880072003842	homodimer interface [polypeptide binding]; other site
880072003843	pyridoxal 5'-phosphate binding site [chemical binding]; other site
880072003844	catalytic residue [active]
880072003845	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
880072003846	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
880072003847	ligand binding site [chemical binding]; other site
880072003848	NAD binding site [chemical binding]; other site
880072003849	dimerization interface [polypeptide binding]; other site
880072003850	catalytic site [active]
880072003851	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
880072003852	putative L-serine binding site [chemical binding]; other site
880072003853	Domain of unknown function (DUF1844); Region: DUF1844; pfam08899
880072003854	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14614
880072003855	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
880072003856	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
880072003857	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
880072003858	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
880072003859	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
880072003860	active site
880072003861	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
880072003862	putative active site [active]
880072003863	catalytic residue [active]
880072003864	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
880072003865	potassium uptake protein; Region: kup; TIGR00794
880072003866	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
880072003867	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
880072003868	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
880072003869	TrkA-N domain; Region: TrkA_N; pfam02254
880072003870	TrkA-C domain; Region: TrkA_C; pfam02080
880072003871	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443
880072003872	NADP-dependent malic enzyme; Provisional; Region: PLN03129
880072003873	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
880072003874	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
880072003875	putative active site [active]
880072003876	putative NTP binding site [chemical binding]; other site
880072003877	putative nucleic acid binding site [nucleotide binding]; other site
880072003878	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
880072003879	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
880072003880	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
880072003881	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
880072003882	isocitrate dehydrogenase; Validated; Region: PRK07362
880072003883	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
880072003884	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
880072003885	putative ribose interaction site [chemical binding]; other site
880072003886	putative ADP binding site [chemical binding]; other site
880072003887	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
880072003888	active site
880072003889	HIGH motif; other site
880072003890	nucleotide binding site [chemical binding]; other site
880072003891	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
880072003892	diiron binding motif [ion binding]; other site
880072003893	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
880072003894	cyclase homology domain; Region: CHD; cd07302
880072003895	nucleotidyl binding site; other site
880072003896	metal binding site [ion binding]; metal-binding site
880072003897	dimer interface [polypeptide binding]; other site
880072003898	Putative Fe-S cluster; Region: FeS; cl17515
880072003899	Domain of unknown function (DUF3786); Region: DUF3786; pfam12654
880072003900	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
880072003901	muropeptide transporter; Reviewed; Region: ampG; PRK11902
880072003902	putative substrate translocation pore; other site
880072003903	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
880072003904	DNA-binding site [nucleotide binding]; DNA binding site
880072003905	RNA-binding motif; other site
880072003906	translation initiation factor IF-2; Validated; Region: infB; PRK05306
880072003907	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
880072003908	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
880072003909	FecR protein; Region: FecR; pfam04773
880072003910	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072003911	binding surface
880072003912	TPR repeat; Region: TPR_11; pfam13414
880072003913	TPR motif; other site
880072003914	Tetratricopeptide repeat; Region: TPR_16; pfam13432
880072003915	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
880072003916	binding surface
880072003917	Tetratricopeptide repeat; Region: TPR_16; pfam13432
880072003918	TPR motif; other site
880072003919	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789
880072003920	Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046
880072003921	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
880072003922	dimerization interface [polypeptide binding]; other site
880072003923	ATP binding site [chemical binding]; other site
880072003924	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
880072003925	dimerization interface [polypeptide binding]; other site
880072003926	ATP binding site [chemical binding]; other site
880072003927	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
880072003928	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
880072003929	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
880072003930	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
880072003931	Ferredoxin [Energy production and conversion]; Region: COG1146
880072003932	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
880072003933	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
880072003934	hybrid cluster protein; Provisional; Region: PRK05290
880072003935	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
880072003936	ACS interaction site; other site
880072003937	CODH interaction site; other site
880072003938	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
880072003939	hybrid metal cluster; other site
880072003940	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
880072003941	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
880072003942	ligand binding site [chemical binding]; other site
880072003943	flexible hinge region; other site
880072003944	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
880072003945	putative switch regulator; other site
880072003946	non-specific DNA interactions [nucleotide binding]; other site
880072003947	DNA binding site [nucleotide binding]
880072003948	sequence specific DNA binding site [nucleotide binding]; other site
880072003949	putative cAMP binding site [chemical binding]; other site
880072003950	FOG: CBS domain [General function prediction only]; Region: COG0517
880072003951	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
880072003952	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
880072003953	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
880072003954	transmembrane helices; other site
880072003955	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
880072003956	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
880072003957	transmembrane helices; other site
880072003958	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
880072003959	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
880072003960	transmembrane helices; other site
880072003961	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
880072003962	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
880072003963	Ligand Binding Site [chemical binding]; other site
880072003964	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
880072003965	GAF domain; Region: GAF_3; pfam13492
880072003966	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072003967	dimer interface [polypeptide binding]; other site
880072003968	phosphorylation site [posttranslational modification]
880072003969	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072003970	ATP binding site [chemical binding]; other site
880072003971	Mg2+ binding site [ion binding]; other site
880072003972	G-X-G motif; other site
880072003973	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
880072003974	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072003975	active site
880072003976	phosphorylation site [posttranslational modification]
880072003977	intermolecular recognition site; other site
880072003978	dimerization interface [polypeptide binding]; other site
880072003979	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
880072003980	DNA binding site [nucleotide binding]
880072003981	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
880072003982	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
880072003983	Bacterial sugar transferase; Region: Bac_transf; pfam02397
880072003984	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
880072003985	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
880072003986	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
880072003987	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
880072003988	Chain length determinant protein; Region: Wzz; cl15801
880072003989	chain length determinant protein EpsF; Region: EpsF; TIGR03017
880072003990	Chain length determinant protein; Region: Wzz; cl15801
880072003991	O-Antigen ligase; Region: Wzy_C; pfam04932
880072003992	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
880072003993	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
880072003994	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
880072003995	colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005
880072003996	putative ADP-binding pocket [chemical binding]; other site
880072003997	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
880072003998	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
880072003999	active site
880072004000	dimer interface [polypeptide binding]; other site
880072004001	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
880072004002	Ligand Binding Site [chemical binding]; other site
880072004003	Molecular Tunnel; other site
880072004004	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
880072004005	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
880072004006	active site
880072004007	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
880072004008	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
880072004009	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
880072004010	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
880072004011	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
880072004012	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
880072004013	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412
880072004014	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
880072004015	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
880072004016	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
880072004017	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
880072004018	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
880072004019	motif II; other site
880072004020	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
880072004021	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
880072004022	Protein of unknown function (DUF499); Region: DUF499; pfam04465
880072004023	Protein of unknown function (DUF1156); Region: DUF1156; pfam06634
880072004024	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
880072004025	Methyltransferase domain; Region: Methyltransf_26; pfam13659
880072004026	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179
880072004027	putative active site [active]
880072004028	catalytic site [active]
880072004029	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
880072004030	ATP binding site [chemical binding]; other site
880072004031	putative Mg++ binding site [ion binding]; other site
880072004032	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
880072004033	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
880072004034	nucleotide binding region [chemical binding]; other site
880072004035	ATP-binding site [chemical binding]; other site
880072004036	Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170
880072004037	PLD-like domain; Region: PLDc_2; pfam13091
880072004038	putative active site [active]
880072004039	catalytic site [active]
880072004040	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
880072004041	catalytic loop [active]
880072004042	iron binding site [ion binding]; other site
880072004043	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
880072004044	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
880072004045	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
880072004046	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
880072004047	dimer interface [polypeptide binding]; other site
880072004048	[2Fe-2S] cluster binding site [ion binding]; other site
880072004049	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
880072004050	SLBB domain; Region: SLBB; pfam10531
880072004051	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
880072004052	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
880072004053	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
880072004054	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
880072004055	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
880072004056	putative dimer interface [polypeptide binding]; other site
880072004057	[2Fe-2S] cluster binding site [ion binding]; other site
880072004058	pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865
880072004059	Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376
880072004060	TPP-binding site [chemical binding]; other site
880072004061	putative dimer interface [polypeptide binding]; other site
880072004062	pyruvate ferredoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK08367
880072004063	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
880072004064	dimer interface [polypeptide binding]; other site
880072004065	PYR/PP interface [polypeptide binding]; other site
880072004066	TPP binding site [chemical binding]; other site
880072004067	substrate binding site [chemical binding]; other site
880072004068	2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179
880072004069	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
880072004070	pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029
880072004071	2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; Region: PorC_KorC; TIGR02175
880072004072	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
880072004073	Active_site [active]
880072004074	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
880072004075	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
880072004076	dimer interface [polypeptide binding]; other site
880072004077	conserved gate region; other site
880072004078	putative PBP binding loops; other site
880072004079	ABC-ATPase subunit interface; other site
880072004080	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
880072004081	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
880072004082	Ligand Binding Site [chemical binding]; other site
880072004083	TilS substrate binding domain; Region: TilS; pfam09179
880072004084	TilS substrate C-terminal domain; Region: TilS_C; smart00977
880072004085	Response regulator receiver domain; Region: Response_reg; pfam00072
880072004086	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072004087	active site
880072004088	phosphorylation site [posttranslational modification]
880072004089	intermolecular recognition site; other site
880072004090	dimerization interface [polypeptide binding]; other site
880072004091	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
880072004092	dimerization interface [polypeptide binding]; other site
880072004093	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
880072004094	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072004095	dimer interface [polypeptide binding]; other site
880072004096	phosphorylation site [posttranslational modification]
880072004097	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072004098	ATP binding site [chemical binding]; other site
880072004099	Mg2+ binding site [ion binding]; other site
880072004100	G-X-G motif; other site
880072004101	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
880072004102	Uncharacterized conserved protein [Function unknown]; Region: COG1615
880072004103	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
880072004104	Septum formation initiator; Region: DivIC; pfam04977
880072004105	elongation factor P; Validated; Region: PRK00529
880072004106	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
880072004107	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
880072004108	RNA binding site [nucleotide binding]; other site
880072004109	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
880072004110	RNA binding site [nucleotide binding]; other site
880072004111	3D domain; Region: 3D; cl01439
880072004112	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
880072004113	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
880072004114	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
880072004115	Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729
880072004116	GTP1/OBG; Region: GTP1_OBG; pfam01018
880072004117	Obg GTPase; Region: Obg; cd01898
880072004118	G1 box; other site
880072004119	GTP/Mg2+ binding site [chemical binding]; other site
880072004120	Switch I region; other site
880072004121	G2 box; other site
880072004122	G3 box; other site
880072004123	Switch II region; other site
880072004124	G4 box; other site
880072004125	G5 box; other site
880072004126	gamma-glutamyl kinase; Provisional; Region: PRK05429
880072004127	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
880072004128	nucleotide binding site [chemical binding]; other site
880072004129	homotetrameric interface [polypeptide binding]; other site
880072004130	putative phosphate binding site [ion binding]; other site
880072004131	putative allosteric binding site; other site
880072004132	PUA domain; Region: PUA; pfam01472
880072004133	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
880072004134	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
880072004135	putative catalytic cysteine [active]
880072004136	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
880072004137	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
880072004138	active site
880072004139	(T/H)XGH motif; other site
880072004140	Peptidase family M48; Region: Peptidase_M48; pfam01435
880072004141	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072004142	binding surface
880072004143	Tetratricopeptide repeat; Region: TPR_16; pfam13432
880072004144	TPR motif; other site
880072004145	Tetratricopeptide repeat; Region: TPR_16; pfam13432
880072004146	TPR repeat; Region: TPR_11; pfam13414
880072004147	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
880072004148	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
880072004149	putative active site [active]
880072004150	putative metal binding site [ion binding]; other site
880072004151	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
880072004152	Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200
880072004153	Protein of unknown function (DUF1614); Region: DUF1614; pfam07758
880072004154	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
880072004155	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072004156	Walker A motif; other site
880072004157	ATP binding site [chemical binding]; other site
880072004158	Walker B motif; other site
880072004159	arginine finger; other site
880072004160	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
880072004161	Predicted periplasmic protein [Function unknown]; Region: COG3698
880072004162	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
880072004163	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
880072004164	active site
880072004165	Methyltransferase domain; Region: Methyltransf_26; pfam13659
880072004166	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
880072004167	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
880072004168	catalytic residue [active]
880072004169	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
880072004170	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
880072004171	catalytic residues [active]
880072004172	Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775
880072004173	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
880072004174	HEPN domain; Region: HEPN; pfam05168
880072004175	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
880072004176	active site
880072004177	NTP binding site [chemical binding]; other site
880072004178	metal binding triad [ion binding]; metal-binding site
880072004179	antibiotic binding site [chemical binding]; other site
880072004180	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
880072004181	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
880072004182	Peptidase family M50; Region: Peptidase_M50; pfam02163
880072004183	active site
880072004184	putative substrate binding region [chemical binding]; other site
880072004185	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
880072004186	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
880072004187	active site
880072004188	substrate binding site [chemical binding]; other site
880072004189	metal binding site [ion binding]; metal-binding site
880072004190	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
880072004191	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
880072004192	homotetramer interface [polypeptide binding]; other site
880072004193	ligand binding site [chemical binding]; other site
880072004194	catalytic site [active]
880072004195	NAD binding site [chemical binding]; other site
880072004196	S-adenosylmethionine synthetase; Validated; Region: PRK05250
880072004197	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
880072004198	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
880072004199	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
880072004200	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
880072004201	tetramerization interface [polypeptide binding]; other site
880072004202	active site
880072004203	pantoate--beta-alanine ligase; Region: panC; TIGR00018
880072004204	Pantoate-beta-alanine ligase; Region: PanC; cd00560
880072004205	active site
880072004206	ATP-binding site [chemical binding]; other site
880072004207	pantoate-binding site; other site
880072004208	HXXH motif; other site
880072004209	FOG: CBS domain [General function prediction only]; Region: COG0517
880072004210	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
880072004211	FOG: CBS domain [General function prediction only]; Region: COG0517
880072004212	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
880072004213	FOG: CBS domain [General function prediction only]; Region: COG0517
880072004214	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
880072004215	Predicted membrane protein [Function unknown]; Region: COG2119
880072004216	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
880072004217	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
880072004218	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
880072004219	Protein export membrane protein; Region: SecD_SecF; cl14618
880072004220	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
880072004221	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
880072004222	HlyD family secretion protein; Region: HlyD_3; pfam13437
880072004223	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
880072004224	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
880072004225	UbiA prenyltransferase family; Region: UbiA; pfam01040
880072004226	menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701
880072004227	Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621
880072004228	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
880072004229	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
880072004230	active site
880072004231	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
880072004232	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
880072004233	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
880072004234	FeS/SAM binding site; other site
880072004235	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
880072004236	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
880072004237	FeS/SAM binding site; other site
880072004238	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
880072004239	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
880072004240	DDE superfamily endonuclease; Region: DDE_5; cl17874
880072004241	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
880072004242	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
880072004243	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
880072004244	HIGH motif; other site
880072004245	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
880072004246	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
880072004247	active site
880072004248	KMSKS motif; other site
880072004249	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
880072004250	tRNA binding surface [nucleotide binding]; other site
880072004251	anticodon binding site; other site
880072004252	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
880072004253	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
880072004254	histidinol dehydrogenase; Region: hisD; TIGR00069
880072004255	NAD binding site [chemical binding]; other site
880072004256	dimerization interface [polypeptide binding]; other site
880072004257	product binding site; other site
880072004258	substrate binding site [chemical binding]; other site
880072004259	zinc binding site [ion binding]; other site
880072004260	catalytic residues [active]
880072004261	putative GTP cyclohydrolase; Provisional; Region: PRK13674
880072004262	C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716
880072004263	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072004264	S-adenosylmethionine binding site [chemical binding]; other site
880072004265	Uncharacterized conserved protein [Function unknown]; Region: COG0398
880072004266	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
880072004267	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
880072004268	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
880072004269	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
880072004270	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
880072004271	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
880072004272	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
880072004273	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
880072004274	active site
880072004275	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
880072004276	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
880072004277	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
880072004278	alphaNTD homodimer interface [polypeptide binding]; other site
880072004279	alphaNTD - beta interaction site [polypeptide binding]; other site
880072004280	alphaNTD - beta' interaction site [polypeptide binding]; other site
880072004281	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
880072004282	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
880072004283	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
880072004284	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
880072004285	RNA binding surface [nucleotide binding]; other site
880072004286	30S ribosomal protein S11; Validated; Region: PRK05309
880072004287	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
880072004288	30S ribosomal protein S13; Region: bact_S13; TIGR03631
880072004289	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
880072004290	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
880072004291	rRNA binding site [nucleotide binding]; other site
880072004292	predicted 30S ribosome binding site; other site
880072004293	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
880072004294	active site
880072004295	adenylate kinase; Reviewed; Region: adk; PRK00279
880072004296	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
880072004297	AMP-binding site [chemical binding]; other site
880072004298	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
880072004299	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
880072004300	SecY translocase; Region: SecY; pfam00344
880072004301	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
880072004302	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
880072004303	23S rRNA binding site [nucleotide binding]; other site
880072004304	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
880072004305	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
880072004306	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
880072004307	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
880072004308	23S rRNA interface [nucleotide binding]; other site
880072004309	5S rRNA interface [nucleotide binding]; other site
880072004310	L27 interface [polypeptide binding]; other site
880072004311	L5 interface [polypeptide binding]; other site
880072004312	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
880072004313	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
880072004314	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
880072004315	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
880072004316	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
880072004317	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
880072004318	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
880072004319	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
880072004320	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
880072004321	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
880072004322	RNA binding site [nucleotide binding]; other site
880072004323	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
880072004324	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
880072004325	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
880072004326	trigger factor interaction site; other site
880072004327	23S rRNA interface [nucleotide binding]; other site
880072004328	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
880072004329	23S rRNA interface [nucleotide binding]; other site
880072004330	5S rRNA interface [nucleotide binding]; other site
880072004331	putative antibiotic binding site [chemical binding]; other site
880072004332	L25 interface [polypeptide binding]; other site
880072004333	L27 interface [polypeptide binding]; other site
880072004334	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
880072004335	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
880072004336	G-X-X-G motif; other site
880072004337	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
880072004338	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
880072004339	putative translocon binding site; other site
880072004340	protein-rRNA interface [nucleotide binding]; other site
880072004341	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
880072004342	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
880072004343	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
880072004344	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
880072004345	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
880072004346	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
880072004347	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
880072004348	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
880072004349	elongation factor Tu; Reviewed; Region: PRK00049
880072004350	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
880072004351	G1 box; other site
880072004352	GEF interaction site [polypeptide binding]; other site
880072004353	GTP/Mg2+ binding site [chemical binding]; other site
880072004354	Switch I region; other site
880072004355	G2 box; other site
880072004356	G3 box; other site
880072004357	Switch II region; other site
880072004358	G4 box; other site
880072004359	G5 box; other site
880072004360	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
880072004361	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
880072004362	Antibiotic Binding Site [chemical binding]; other site
880072004363	elongation factor G; Reviewed; Region: PRK00007
880072004364	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
880072004365	G1 box; other site
880072004366	putative GEF interaction site [polypeptide binding]; other site
880072004367	GTP/Mg2+ binding site [chemical binding]; other site
880072004368	Switch I region; other site
880072004369	G2 box; other site
880072004370	G3 box; other site
880072004371	Switch II region; other site
880072004372	G4 box; other site
880072004373	G5 box; other site
880072004374	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
880072004375	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
880072004376	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
880072004377	30S ribosomal protein S7; Validated; Region: PRK05302
880072004378	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
880072004379	S17 interaction site [polypeptide binding]; other site
880072004380	S8 interaction site; other site
880072004381	16S rRNA interaction site [nucleotide binding]; other site
880072004382	streptomycin interaction site [chemical binding]; other site
880072004383	23S rRNA interaction site [nucleotide binding]; other site
880072004384	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
880072004385	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
880072004386	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
880072004387	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
880072004388	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
880072004389	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
880072004390	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
880072004391	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
880072004392	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
880072004393	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
880072004394	DNA binding site [nucleotide binding]
880072004395	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
880072004396	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
880072004397	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
880072004398	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
880072004399	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
880072004400	RPB11 interaction site [polypeptide binding]; other site
880072004401	RPB12 interaction site [polypeptide binding]; other site
880072004402	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
880072004403	RPB3 interaction site [polypeptide binding]; other site
880072004404	RPB1 interaction site [polypeptide binding]; other site
880072004405	RPB11 interaction site [polypeptide binding]; other site
880072004406	RPB10 interaction site [polypeptide binding]; other site
880072004407	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
880072004408	core dimer interface [polypeptide binding]; other site
880072004409	peripheral dimer interface [polypeptide binding]; other site
880072004410	L10 interface [polypeptide binding]; other site
880072004411	L11 interface [polypeptide binding]; other site
880072004412	putative EF-Tu interaction site [polypeptide binding]; other site
880072004413	putative EF-G interaction site [polypeptide binding]; other site
880072004414	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
880072004415	23S rRNA interface [nucleotide binding]; other site
880072004416	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
880072004417	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
880072004418	mRNA/rRNA interface [nucleotide binding]; other site
880072004419	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
880072004420	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
880072004421	23S rRNA interface [nucleotide binding]; other site
880072004422	L7/L12 interface [polypeptide binding]; other site
880072004423	putative thiostrepton binding site; other site
880072004424	L25 interface [polypeptide binding]; other site
880072004425	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
880072004426	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
880072004427	putative homodimer interface [polypeptide binding]; other site
880072004428	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
880072004429	heterodimer interface [polypeptide binding]; other site
880072004430	homodimer interface [polypeptide binding]; other site
880072004431	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
880072004432	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
880072004433	elongation factor Tu; Reviewed; Region: PRK00049
880072004434	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
880072004435	G1 box; other site
880072004436	GEF interaction site [polypeptide binding]; other site
880072004437	GTP/Mg2+ binding site [chemical binding]; other site
880072004438	Switch I region; other site
880072004439	G2 box; other site
880072004440	G3 box; other site
880072004441	Switch II region; other site
880072004442	G4 box; other site
880072004443	G5 box; other site
880072004444	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
880072004445	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
880072004446	Antibiotic Binding Site [chemical binding]; other site
880072004447	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
880072004448	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
880072004449	DNA binding residues [nucleotide binding]
880072004450	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
880072004451	Cysteine-rich domain; Region: CCG; pfam02754
880072004452	Cysteine-rich domain; Region: CCG; pfam02754
880072004453	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
880072004454	YbbR-like protein; Region: YbbR; pfam07949
880072004455	TIGR00159 family protein; Region: TIGR00159
880072004456	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
880072004457	dihydropteroate synthase; Region: DHPS; TIGR01496
880072004458	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
880072004459	substrate binding pocket [chemical binding]; other site
880072004460	dimer interface [polypeptide binding]; other site
880072004461	inhibitor binding site; inhibition site
880072004462	FtsH Extracellular; Region: FtsH_ext; pfam06480
880072004463	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
880072004464	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072004465	Walker A motif; other site
880072004466	ATP binding site [chemical binding]; other site
880072004467	Walker B motif; other site
880072004468	arginine finger; other site
880072004469	Peptidase family M41; Region: Peptidase_M41; pfam01434
880072004470	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
880072004471	phosphate binding site [ion binding]; other site
880072004472	Helix-turn-helix domain; Region: HTH_17; pfam12728
880072004473	Helix-turn-helix domain; Region: HTH_17; pfam12728
880072004474	Helix-turn-helix domain; Region: HTH_17; pfam12728
880072004475	Terminase-like family; Region: Terminase_6; pfam03237
880072004476	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
880072004477	ChaB; Region: ChaB; cl01887
880072004478	Protein of unknown function (DUF935); Region: DUF935; pfam06074
880072004479	Mu-like prophage protein gp29 [Function unknown]; Region: COG4383
880072004480	Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123
880072004481	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
880072004482	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
880072004483	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
880072004484	Protein of unknown function (DUF1320); Region: DUF1320; pfam07030
880072004485	Domain of unknown function (DUF1834); Region: DUF1834; cl02087
880072004486	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
880072004487	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
880072004488	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
880072004489	ligand binding site [chemical binding]; other site
880072004490	flexible hinge region; other site
880072004491	Response regulator receiver domain; Region: Response_reg; pfam00072
880072004492	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072004493	active site
880072004494	phosphorylation site [posttranslational modification]
880072004495	intermolecular recognition site; other site
880072004496	dimerization interface [polypeptide binding]; other site
880072004497	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
880072004498	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
880072004499	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
880072004500	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072004501	dimer interface [polypeptide binding]; other site
880072004502	phosphorylation site [posttranslational modification]
880072004503	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072004504	ATP binding site [chemical binding]; other site
880072004505	Mg2+ binding site [ion binding]; other site
880072004506	G-X-G motif; other site
880072004507	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
880072004508	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072004509	active site
880072004510	phosphorylation site [posttranslational modification]
880072004511	intermolecular recognition site; other site
880072004512	dimerization interface [polypeptide binding]; other site
880072004513	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072004514	Walker A motif; other site
880072004515	ATP binding site [chemical binding]; other site
880072004516	Walker B motif; other site
880072004517	arginine finger; other site
880072004518	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
880072004519	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916
880072004520	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
880072004521	inhibitor-cofactor binding pocket; inhibition site
880072004522	pyridoxal 5'-phosphate binding site [chemical binding]; other site
880072004523	catalytic residue [active]
880072004524	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
880072004525	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
880072004526	Ligand binding site; other site
880072004527	oligomer interface; other site
880072004528	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
880072004529	Clp amino terminal domain; Region: Clp_N; pfam02861
880072004530	Clp amino terminal domain; Region: Clp_N; pfam02861
880072004531	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072004532	Walker A motif; other site
880072004533	ATP binding site [chemical binding]; other site
880072004534	Walker B motif; other site
880072004535	arginine finger; other site
880072004536	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072004537	Walker A motif; other site
880072004538	ATP binding site [chemical binding]; other site
880072004539	Walker B motif; other site
880072004540	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
880072004541	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
880072004542	Permease; Region: Permease; pfam02405
880072004543	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
880072004544	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
880072004545	Walker A/P-loop; other site
880072004546	ATP binding site [chemical binding]; other site
880072004547	Q-loop/lid; other site
880072004548	ABC transporter signature motif; other site
880072004549	Walker B; other site
880072004550	D-loop; other site
880072004551	H-loop/switch region; other site
880072004552	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
880072004553	mce related protein; Region: MCE; pfam02470
880072004554	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
880072004555	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
880072004556	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
880072004557	CoenzymeA binding site [chemical binding]; other site
880072004558	subunit interaction site [polypeptide binding]; other site
880072004559	PHB binding site; other site
880072004560	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
880072004561	putative acyl-acceptor binding pocket; other site
880072004562	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
880072004563	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
880072004564	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
880072004565	TPR repeat; Region: TPR_11; pfam13414
880072004566	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072004567	binding surface
880072004568	TPR motif; other site
880072004569	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
880072004570	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
880072004571	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
880072004572	Substrate binding site; other site
880072004573	metal-binding site
880072004574	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
880072004575	putative trimer interface [polypeptide binding]; other site
880072004576	putative CoA binding site [chemical binding]; other site
880072004577	Adenosine specific kinase; Region: Adenosine_kin; pfam04008
880072004578	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
880072004579	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
880072004580	oligomer interface [polypeptide binding]; other site
880072004581	metal binding site [ion binding]; metal-binding site
880072004582	metal binding site [ion binding]; metal-binding site
880072004583	Cl binding site [ion binding]; other site
880072004584	aspartate ring; other site
880072004585	basic sphincter; other site
880072004586	putative hydrophobic gate; other site
880072004587	periplasmic entrance; other site
880072004588	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
880072004589	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
880072004590	putative ligand binding site [chemical binding]; other site
880072004591	DNA gyrase subunit A; Validated; Region: PRK05560
880072004592	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
880072004593	CAP-like domain; other site
880072004594	active site
880072004595	primary dimer interface [polypeptide binding]; other site
880072004596	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
880072004597	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
880072004598	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
880072004599	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
880072004600	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
880072004601	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
880072004602	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
880072004603	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
880072004604	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
880072004605	Flagellin N-methylase; Region: FliB; pfam03692
880072004606	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
880072004607	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
880072004608	active site
880072004609	HIGH motif; other site
880072004610	KMSKS motif; other site
880072004611	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
880072004612	tRNA binding surface [nucleotide binding]; other site
880072004613	anticodon binding site; other site
880072004614	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
880072004615	putative tRNA-binding site [nucleotide binding]; other site
880072004616	dimer interface [polypeptide binding]; other site
880072004617	NlpC/P60 family; Region: NLPC_P60; pfam00877
880072004618	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
880072004619	active site
880072004620	NTP binding site [chemical binding]; other site
880072004621	metal binding triad [ion binding]; metal-binding site
880072004622	antibiotic binding site [chemical binding]; other site
880072004623	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
880072004624	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
880072004625	Protein export membrane protein; Region: SecD_SecF; cl14618
880072004626	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
880072004627	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
880072004628	HlyD family secretion protein; Region: HlyD_3; pfam13437
880072004629	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
880072004630	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
880072004631	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
880072004632	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
880072004633	active site
880072004634	catalytic site [active]
880072004635	aconitate hydratase; Validated; Region: PRK07229
880072004636	Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585
880072004637	substrate binding site [chemical binding]; other site
880072004638	ligand binding site [chemical binding]; other site
880072004639	Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle.  Cis-aconitate is formed as an intermediate product during the course...; Region: AcnA_Bact_Swivel; cd01579
880072004640	substrate binding site [chemical binding]; other site
880072004641	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
880072004642	putative active site [active]
880072004643	putative CoA binding site [chemical binding]; other site
880072004644	nudix motif; other site
880072004645	metal binding site [ion binding]; metal-binding site
880072004646	Uncharacterized conserved protein [Function unknown]; Region: COG1633
880072004647	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
880072004648	diiron binding motif [ion binding]; other site
880072004649	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
880072004650	Uncharacterized conserved protein [Function unknown]; Region: COG3937
880072004651	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
880072004652	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
880072004653	substrate binding pocket [chemical binding]; other site
880072004654	chain length determination region; other site
880072004655	substrate-Mg2+ binding site; other site
880072004656	catalytic residues [active]
880072004657	aspartate-rich region 1; other site
880072004658	active site lid residues [active]
880072004659	aspartate-rich region 2; other site
880072004660	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
880072004661	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
880072004662	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
880072004663	FeS/SAM binding site; other site
880072004664	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
880072004665	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
880072004666	N-acetyl-D-glucosamine binding site [chemical binding]; other site
880072004667	catalytic residue [active]
880072004668	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
880072004669	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
880072004670	nitrilase; Region: PLN02798
880072004671	putative active site [active]
880072004672	catalytic triad [active]
880072004673	dimer interface [polypeptide binding]; other site
880072004674	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
880072004675	ATP binding site [chemical binding]; other site
880072004676	Walker A/P-loop; other site
880072004677	ABC transporter; Region: ABC_tran; pfam00005
880072004678	Q-loop/lid; other site
880072004679	ABC transporter signature motif; other site
880072004680	Walker B; other site
880072004681	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
880072004682	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072004683	ATP binding site [chemical binding]; other site
880072004684	Mg2+ binding site [ion binding]; other site
880072004685	G-X-G motif; other site
880072004686	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
880072004687	ATP binding site [chemical binding]; other site
880072004688	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
880072004689	ribonuclease PH; Reviewed; Region: rph; PRK00173
880072004690	Ribonuclease PH; Region: RNase_PH_bact; cd11362
880072004691	hexamer interface [polypeptide binding]; other site
880072004692	active site
880072004693	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
880072004694	active site
880072004695	dimerization interface [polypeptide binding]; other site
880072004696	Helix-turn-helix domain; Region: HTH_18; pfam12833
880072004697	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
880072004698	flavodoxin; Provisional; Region: PRK06242
880072004699	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
880072004700	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
880072004701	dimerization interface [polypeptide binding]; other site
880072004702	putative DNA binding site [nucleotide binding]; other site
880072004703	putative Zn2+ binding site [ion binding]; other site
880072004704	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
880072004705	active site
880072004706	NTP binding site [chemical binding]; other site
880072004707	metal binding triad [ion binding]; metal-binding site
880072004708	antibiotic binding site [chemical binding]; other site
880072004709	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
880072004710	purine monophosphate binding site [chemical binding]; other site
880072004711	dimer interface [polypeptide binding]; other site
880072004712	putative catalytic residues [active]
880072004713	ATP-grasp domain; Region: ATP-grasp_4; cl17255
880072004714	sodium/hydrogen exchanger 3; Region: b_cpa1; TIGR00840
880072004715	hypothetical protein; Provisional; Region: PRK00106
880072004716	hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471
880072004717	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
880072004718	B12 binding site [chemical binding]; other site
880072004719	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
880072004720	FeS/SAM binding site; other site
880072004721	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
880072004722	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
880072004723	FeS/SAM binding site; other site
880072004724	hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804
880072004725	putative active site [active]
880072004726	YdjC motif; other site
880072004727	Mg binding site [ion binding]; other site
880072004728	putative homodimer interface [polypeptide binding]; other site
880072004729	EamA-like transporter family; Region: EamA; cl17759
880072004730	photolyase PhrII; Region: phr2; TIGR00591
880072004731	DNA photolyase; Region: DNA_photolyase; pfam00875
880072004732	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
880072004733	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
880072004734	Transporter associated domain; Region: CorC_HlyC; smart01091
880072004735	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675
880072004736	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
880072004737	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
880072004738	non-specific DNA binding site [nucleotide binding]; other site
880072004739	salt bridge; other site
880072004740	sequence-specific DNA binding site [nucleotide binding]; other site
880072004741	Cupin domain; Region: Cupin_2; pfam07883
880072004742	Predicted transcriptional regulator containing an HTH domain fused to a Zn-ribbon [Transcription]; Region: COG3357
880072004743	Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893
880072004744	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
880072004745	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
880072004746	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
880072004747	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
880072004748	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
880072004749	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
880072004750	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
880072004751	mce related protein; Region: MCE; pfam02470
880072004752	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
880072004753	Histone deacetylase (HDAC) classes I, II, IV and related proteins; Region: HDAC; cd09301
880072004754	active site
880072004755	Zn binding site [ion binding]; other site
880072004756	AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335
880072004757	AMMECR1; Region: AMMECR1; pfam01871
880072004758	Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; cl11978
880072004759	FOG: CBS domain [General function prediction only]; Region: COG0517
880072004760	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
880072004761	L-aspartate oxidase; Provisional; Region: PRK09077
880072004762	L-aspartate oxidase; Provisional; Region: PRK06175
880072004763	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
880072004764	enoyl-CoA hydratase; Validated; Region: PRK08139
880072004765	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
880072004766	substrate binding site [chemical binding]; other site
880072004767	oxyanion hole (OAH) forming residues; other site
880072004768	trimer interface [polypeptide binding]; other site
880072004769	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
880072004770	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072004771	putative active site [active]
880072004772	heme pocket [chemical binding]; other site
880072004773	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072004774	dimer interface [polypeptide binding]; other site
880072004775	phosphorylation site [posttranslational modification]
880072004776	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072004777	ATP binding site [chemical binding]; other site
880072004778	Mg2+ binding site [ion binding]; other site
880072004779	G-X-G motif; other site
880072004780	Response regulator receiver domain; Region: Response_reg; pfam00072
880072004781	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072004782	active site
880072004783	phosphorylation site [posttranslational modification]
880072004784	intermolecular recognition site; other site
880072004785	dimerization interface [polypeptide binding]; other site
880072004786	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
880072004787	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
880072004788	ligand binding site; other site
880072004789	oligomer interface; other site
880072004790	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
880072004791	N-terminal domain interface [polypeptide binding]; other site
880072004792	sulfate 1 binding site; other site
880072004793	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
880072004794	catalytic core [active]
880072004795	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
880072004796	Low molecular weight phosphatase family; Region: LMWPc; cd00115
880072004797	active site
880072004798	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
880072004799	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
880072004800	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
880072004801	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
880072004802	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
880072004803	catalytic residues [active]
880072004804	Predicted permeases [General function prediction only]; Region: COG0701
880072004805	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
880072004806	dimerization interface [polypeptide binding]; other site
880072004807	putative DNA binding site [nucleotide binding]; other site
880072004808	putative Zn2+ binding site [ion binding]; other site
880072004809	diaminopimelate aminotransferase; Provisional; Region: PRK13983
880072004810	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like1; cd05650
880072004811	metal binding site [ion binding]; metal-binding site
880072004812	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072004813	S-adenosylmethionine binding site [chemical binding]; other site
880072004814	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
880072004815	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
880072004816	Walker A/P-loop; other site
880072004817	ATP binding site [chemical binding]; other site
880072004818	Q-loop/lid; other site
880072004819	ABC transporter signature motif; other site
880072004820	Walker B; other site
880072004821	D-loop; other site
880072004822	H-loop/switch region; other site
880072004823	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
880072004824	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
880072004825	FtsX-like permease family; Region: FtsX; pfam02687
880072004826	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
880072004827	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
880072004828	Uncharacterized subfamily of S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase_like; cd11724
880072004829	Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798
880072004830	putative SAM binding site [chemical binding]; other site
880072004831	putative homodimer interface [polypeptide binding]; other site
880072004832	Soluble P-type ATPase [General function prediction only]; Region: COG4087
880072004833	pyruvate phosphate dikinase; Provisional; Region: PRK05878
880072004834	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
880072004835	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
880072004836	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
880072004837	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072004838	S-adenosylmethionine binding site [chemical binding]; other site
880072004839	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
880072004840	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
880072004841	DNA binding site [nucleotide binding]
880072004842	active site
880072004843	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
880072004844	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
880072004845	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
880072004846	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
880072004847	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
880072004848	ATP-grasp domain; Region: ATP-grasp_4; cl17255
880072004849	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
880072004850	Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016
880072004851	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
880072004852	active site
880072004853	catalytic residues [active]
880072004854	metal binding site [ion binding]; metal-binding site
880072004855	homodimer binding site [polypeptide binding]; other site
880072004856	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
880072004857	putative ligand binding pocket/active site [active]
880072004858	putative metal binding site [ion binding]; other site
880072004859	cobyric acid synthase; Provisional; Region: PRK00784
880072004860	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
880072004861	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
880072004862	catalytic triad [active]
880072004863	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
880072004864	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
880072004865	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
880072004866	catalytic triad [active]
880072004867	sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066
880072004868	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
880072004869	4Fe-4S binding domain; Region: Fer4; pfam00037
880072004870	sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064
880072004871	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
880072004872	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
880072004873	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
880072004874	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
880072004875	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
880072004876	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
880072004877	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
880072004878	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
880072004879	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
880072004880	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
880072004881	Catalytic site [active]
880072004882	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
880072004883	GTP-binding protein LepA; Provisional; Region: PRK05433
880072004884	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
880072004885	G1 box; other site
880072004886	putative GEF interaction site [polypeptide binding]; other site
880072004887	GTP/Mg2+ binding site [chemical binding]; other site
880072004888	Switch I region; other site
880072004889	G2 box; other site
880072004890	G3 box; other site
880072004891	Switch II region; other site
880072004892	G4 box; other site
880072004893	G5 box; other site
880072004894	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
880072004895	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
880072004896	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
880072004897	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
880072004898	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
880072004899	putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498
880072004900	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
880072004901	dimer interface [polypeptide binding]; other site
880072004902	putative functional site; other site
880072004903	putative MPT binding site; other site
880072004904	PBP superfamily domain; Region: PBP_like; pfam12727
880072004905	putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827
880072004906	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
880072004907	Ligand Binding Site [chemical binding]; other site
880072004908	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
880072004909	Ligand Binding Site [chemical binding]; other site
880072004910	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
880072004911	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
880072004912	active site
880072004913	homodimer interface [polypeptide binding]; other site
880072004914	Protein of unknown function (DUF1640); Region: DUF1640; pfam07798
880072004915	Protein of unknown function (DUF1640); Region: DUF1640; pfam07798
880072004916	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
880072004917	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
880072004918	NAD(P) binding site [chemical binding]; other site
880072004919	active site
880072004920	DDE superfamily endonuclease; Region: DDE_5; cl17874
880072004921	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
880072004922	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
880072004923	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
880072004924	putative NAD(P) binding site [chemical binding]; other site
880072004925	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
880072004926	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
880072004927	Protein of unknown function (DUF1640); Region: DUF1640; pfam07798
880072004928	Protein of unknown function (DUF1640); Region: DUF1640; pfam07798
880072004929	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941
880072004930	polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006
880072004931	putative active site [active]
880072004932	putative catalytic site [active]
880072004933	putative glycosyl transferase; Provisional; Region: PRK10307
880072004934	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
880072004935	carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767
880072004936	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
880072004937	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
880072004938	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
880072004939	active site
880072004940	Methyltransferase domain; Region: Methyltransf_31; pfam13847
880072004941	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072004942	S-adenosylmethionine binding site [chemical binding]; other site
880072004943	YcfA-like protein; Region: YcfA; cl00752
880072004944	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
880072004945	Methyltransferase domain; Region: Methyltransf_23; pfam13489
880072004946	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072004947	S-adenosylmethionine binding site [chemical binding]; other site
880072004948	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
880072004949	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
880072004950	putative metal binding site; other site
880072004951	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
880072004952	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
880072004953	putative ADP-binding pocket [chemical binding]; other site
880072004954	DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996
880072004955	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
880072004956	Methyltransferase domain; Region: Methyltransf_23; pfam13489
880072004957	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072004958	S-adenosylmethionine binding site [chemical binding]; other site
880072004959	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
880072004960	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
880072004961	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072004962	S-adenosylmethionine binding site [chemical binding]; other site
880072004963	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
880072004964	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_epsE_like; cd13129
880072004965	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
880072004966	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
880072004967	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
880072004968	putative active site [active]
880072004969	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
880072004970	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
880072004971	active site
880072004972	dimer interface [polypeptide binding]; other site
880072004973	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
880072004974	Ligand Binding Site [chemical binding]; other site
880072004975	Molecular Tunnel; other site
880072004976	PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874
880072004977	putative active site [active]
880072004978	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
880072004979	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
880072004980	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
880072004981	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
880072004982	GAF domain; Region: GAF; cl17456
880072004983	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
880072004984	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072004985	ATP binding site [chemical binding]; other site
880072004986	Mg2+ binding site [ion binding]; other site
880072004987	G-X-G motif; other site
880072004988	Fumarase C-terminus; Region: Fumerase_C; cl00795
880072004989	fumarate hydratase; Provisional; Region: PRK06246
880072004990	Transglycosylase; Region: Transgly; pfam00912
880072004991	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
880072004992	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
880072004993	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
880072004994	active site
880072004995	substrate binding site [chemical binding]; other site
880072004996	cosubstrate binding site; other site
880072004997	catalytic site [active]
880072004998	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
880072004999	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
880072005000	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
880072005001	HIGH motif; other site
880072005002	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
880072005003	active site
880072005004	KMSKS motif; other site
880072005005	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
880072005006	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
880072005007	FMN binding site [chemical binding]; other site
880072005008	substrate binding site [chemical binding]; other site
880072005009	putative catalytic residue [active]
880072005010	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
880072005011	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
880072005012	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
880072005013	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
880072005014	4Fe-4S dicluster domain; Region: Fer4_18; pfam13746
880072005015	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
880072005016	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
880072005017	ligand binding site [chemical binding]; other site
880072005018	flexible hinge region; other site
880072005019	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
880072005020	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
880072005021	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
880072005022	active site
880072005023	Ap6A binding site [chemical binding]; other site
880072005024	nudix motif; other site
880072005025	metal binding site [ion binding]; metal-binding site
880072005026	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
880072005027	Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910
880072005028	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
880072005029	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
880072005030	Uncharacterized conserved protein [Function unknown]; Region: COG3189
880072005031	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
880072005032	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
880072005033	Cupin domain; Region: Cupin_2; cl17218
880072005034	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
880072005035	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
880072005036	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
880072005037	Superoxide dismutase [Fe]; Provisional; Region: PTZ00078
880072005038	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
880072005039	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
880072005040	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
880072005041	Uncharacterized conserved protein (DUF2276); Region: DUF2276; pfam10040
880072005042	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680
880072005043	CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578
880072005044	CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622
880072005045	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
880072005046	CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438
880072005047	CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437
880072005048	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl01634
880072005049	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
880072005050	active site
880072005051	NTP binding site [chemical binding]; other site
880072005052	metal binding triad [ion binding]; metal-binding site
880072005053	antibiotic binding site [chemical binding]; other site
880072005054	CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455
880072005055	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732
880072005056	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439
880072005057	Transposase IS200 like; Region: Y1_Tnp; cl00848
880072005058	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cl00532
880072005059	PemK-like protein; Region: PemK; pfam02452
880072005060	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072005061	binding surface
880072005062	TPR motif; other site
880072005063	Tetratricopeptide repeat; Region: TPR_16; pfam13432
880072005064	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
880072005065	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
880072005066	four helix bundle protein; Region: TIGR02436
880072005067	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
880072005068	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
880072005069	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
880072005070	four helix bundle protein; Region: TIGR02436
880072005071	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
880072005072	CoA binding domain; Region: CoA_binding_2; pfam13380
880072005073	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
880072005074	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
880072005075	PHP domain; Region: PHP; pfam02811
880072005076	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
880072005077	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
880072005078	AAA domain; Region: AAA_23; pfam13476
880072005079	Walker A/P-loop; other site
880072005080	ATP binding site [chemical binding]; other site
880072005081	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
880072005082	oligomer interface [polypeptide binding]; other site
880072005083	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
880072005084	ABC transporter signature motif; other site
880072005085	Walker B; other site
880072005086	D-loop; other site
880072005087	H-loop/switch region; other site
880072005088	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
880072005089	Divergent AAA domain; Region: AAA_4; pfam04326
880072005090	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
880072005091	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
880072005092	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
880072005093	HIGH motif; other site
880072005094	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
880072005095	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
880072005096	active site
880072005097	KMSKS motif; other site
880072005098	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
880072005099	tRNA binding surface [nucleotide binding]; other site
880072005100	Lipopolysaccharide-assembly; Region: LptE; pfam04390
880072005101	DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466
880072005102	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
880072005103	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
880072005104	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
880072005105	Zn2+ binding site [ion binding]; other site
880072005106	Mg2+ binding site [ion binding]; other site
880072005107	Transcriptional regulator [Transcription]; Region: LysR; COG0583
880072005108	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
880072005109	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
880072005110	putative dimerization interface [polypeptide binding]; other site
880072005111	Isochorismatase family; Region: Isochorismatase; pfam00857
880072005112	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
880072005113	catalytic triad [active]
880072005114	conserved cis-peptide bond; other site
880072005115	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
880072005116	Found in ATP-dependent protease La (LON); Region: LON; smart00464
880072005117	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072005118	Walker A motif; other site
880072005119	ATP binding site [chemical binding]; other site
880072005120	Walker B motif; other site
880072005121	arginine finger; other site
880072005122	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
880072005123	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
880072005124	Domain of unknown function DUF21; Region: DUF21; pfam01595
880072005125	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
880072005126	Transporter associated domain; Region: CorC_HlyC; smart01091
880072005127	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
880072005128	Domain of unknown function DUF21; Region: DUF21; pfam01595
880072005129	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
880072005130	Transporter associated domain; Region: CorC_HlyC; smart01091
880072005131	Protein of unknown function DUF111; Region: DUF111; pfam01969
880072005132	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
880072005133	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
880072005134	N-terminal plug; other site
880072005135	ligand-binding site [chemical binding]; other site
880072005136	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
880072005137	Uncharacterized subfamily of S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase_like; cd11724
880072005138	putative SAM binding site [chemical binding]; other site
880072005139	putative homodimer interface [polypeptide binding]; other site
880072005140	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
880072005141	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
880072005142	putative fructoselysine transporter; Provisional; Region: frlA; PRK11357
880072005143	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
880072005144	NAD-dependent deacetylase; Provisional; Region: PRK00481
880072005145	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
880072005146	NAD+ binding site [chemical binding]; other site
880072005147	substrate binding site [chemical binding]; other site
880072005148	Zn binding site [ion binding]; other site
880072005149	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
880072005150	CoA binding domain; Region: CoA_binding_2; pfam13380
880072005151	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
880072005152	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
880072005153	RNB domain; Region: RNB; pfam00773
880072005154	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
880072005155	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
880072005156	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
880072005157	active site
880072005158	metal binding site [ion binding]; metal-binding site
880072005159	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
880072005160	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
880072005161	Coenzyme A binding pocket [chemical binding]; other site
880072005162	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
880072005163	Chain length determinant protein; Region: Wzz; pfam02706
880072005164	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
880072005165	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
880072005166	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
880072005167	SLBB domain; Region: SLBB; pfam10531
880072005168	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
880072005169	O-Antigen ligase; Region: Wzy_C; pfam04932
880072005170	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
880072005171	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
880072005172	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072005173	TPR motif; other site
880072005174	binding surface
880072005175	TPR repeat; Region: TPR_11; pfam13414
880072005176	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072005177	binding surface
880072005178	TPR motif; other site
880072005179	Tetratricopeptide repeat; Region: TPR_16; pfam13432
880072005180	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072005181	binding surface
880072005182	Tetratricopeptide repeat; Region: TPR_16; pfam13432
880072005183	TPR motif; other site
880072005184	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766
880072005185	transcriptional activator RfaH; Region: RfaH; TIGR01955
880072005186	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
880072005187	heterodimer interface [polypeptide binding]; other site
880072005188	homodimer interface [polypeptide binding]; other site
880072005189	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
880072005190	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
880072005191	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072005192	active site
880072005193	phosphorylation site [posttranslational modification]
880072005194	intermolecular recognition site; other site
880072005195	dimerization interface [polypeptide binding]; other site
880072005196	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072005197	active site
880072005198	phosphorylation site [posttranslational modification]
880072005199	intermolecular recognition site; other site
880072005200	dimerization interface [polypeptide binding]; other site
880072005201	Cache domain; Region: Cache_1; pfam02743
880072005202	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
880072005203	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072005204	putative active site [active]
880072005205	heme pocket [chemical binding]; other site
880072005206	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072005207	dimer interface [polypeptide binding]; other site
880072005208	phosphorylation site [posttranslational modification]
880072005209	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072005210	ATP binding site [chemical binding]; other site
880072005211	Mg2+ binding site [ion binding]; other site
880072005212	G-X-G motif; other site
880072005213	Gas vesicle protein; Region: Gas_vesicle; pfam00741
880072005214	Gas vesicle protein K; Region: GvpK; pfam05121
880072005215	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
880072005216	Gas vesicle protein; Region: Gas_vesicle; pfam00741
880072005217	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
880072005218	DTAP/Switch II; other site
880072005219	Switch I; other site
880072005220	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
880072005221	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
880072005222	P loop; other site
880072005223	Nucleotide binding site [chemical binding]; other site
880072005224	DTAP/Switch II; other site
880072005225	Switch I; other site
880072005226	Gas vesicle protein G; Region: GvpG; pfam05120
880072005227	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
880072005228	gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640
880072005229	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072005230	Walker A motif; other site
880072005231	ATP binding site [chemical binding]; other site
880072005232	Walker B motif; other site
880072005233	arginine finger; other site
880072005234	DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684
880072005235	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
880072005236	Zn binding sites [ion binding]; other site
880072005237	DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684
880072005238	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
880072005239	Zn binding sites [ion binding]; other site
880072005240	gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371
880072005241	gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371
880072005242	Response regulator receiver domain; Region: Response_reg; pfam00072
880072005243	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072005244	active site
880072005245	phosphorylation site [posttranslational modification]
880072005246	intermolecular recognition site; other site
880072005247	dimerization interface [polypeptide binding]; other site
880072005248	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
880072005249	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
880072005250	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072005251	putative active site [active]
880072005252	heme pocket [chemical binding]; other site
880072005253	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072005254	dimer interface [polypeptide binding]; other site
880072005255	phosphorylation site [posttranslational modification]
880072005256	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072005257	ATP binding site [chemical binding]; other site
880072005258	Mg2+ binding site [ion binding]; other site
880072005259	G-X-G motif; other site
880072005260	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
880072005261	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
880072005262	AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243
880072005263	Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359
880072005264	Cell division protein 48 (CDC48), domain 2; Region: CDC48_2; pfam02933
880072005265	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072005266	Walker A motif; other site
880072005267	ATP binding site [chemical binding]; other site
880072005268	Walker B motif; other site
880072005269	arginine finger; other site
880072005270	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072005271	Walker A motif; other site
880072005272	ATP binding site [chemical binding]; other site
880072005273	Walker B motif; other site
880072005274	arginine finger; other site
880072005275	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
880072005276	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
880072005277	putative dimer interface [polypeptide binding]; other site
880072005278	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072005279	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
880072005280	active site
880072005281	phosphorylation site [posttranslational modification]
880072005282	intermolecular recognition site; other site
880072005283	dimerization interface [polypeptide binding]; other site
880072005284	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072005285	Walker A motif; other site
880072005286	ATP binding site [chemical binding]; other site
880072005287	Walker B motif; other site
880072005288	arginine finger; other site
880072005289	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
880072005290	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
880072005291	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
880072005292	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072005293	S-adenosylmethionine binding site [chemical binding]; other site
880072005294	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
880072005295	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
880072005296	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
880072005297	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
880072005298	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072005299	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
880072005300	Walker A motif; other site
880072005301	ATP binding site [chemical binding]; other site
880072005302	Walker B motif; other site
880072005303	arginine finger; other site
880072005304	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
880072005305	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
880072005306	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
880072005307	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
880072005308	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
880072005309	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
880072005310	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
880072005311	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
880072005312	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
880072005313	Right handed beta helix region; Region: Beta_helix; pfam13229
880072005314	Protein of unknown function (DUF3192); Region: DUF3192; pfam11399
880072005315	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14463
880072005316	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
880072005317	FeS/SAM binding site; other site
880072005318	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
880072005319	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
880072005320	trimer interface [polypeptide binding]; other site
880072005321	dimer interface [polypeptide binding]; other site
880072005322	putative active site [active]
880072005323	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
880072005324	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
880072005325	HSP70 interaction site [polypeptide binding]; other site
880072005326	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
880072005327	Zn binding sites [ion binding]; other site
880072005328	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
880072005329	dimer interface [polypeptide binding]; other site
880072005330	PAS fold; Region: PAS_7; pfam12860
880072005331	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072005332	PAS fold; Region: PAS_3; pfam08447
880072005333	putative active site [active]
880072005334	heme pocket [chemical binding]; other site
880072005335	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
880072005336	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072005337	putative active site [active]
880072005338	heme pocket [chemical binding]; other site
880072005339	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072005340	dimer interface [polypeptide binding]; other site
880072005341	phosphorylation site [posttranslational modification]
880072005342	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072005343	ATP binding site [chemical binding]; other site
880072005344	Mg2+ binding site [ion binding]; other site
880072005345	G-X-G motif; other site
880072005346	Response regulator receiver domain; Region: Response_reg; pfam00072
880072005347	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072005348	active site
880072005349	phosphorylation site [posttranslational modification]
880072005350	intermolecular recognition site; other site
880072005351	dimerization interface [polypeptide binding]; other site
880072005352	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
880072005353	DNA methylase; Region: N6_N4_Mtase; pfam01555
880072005354	DNA methylase; Region: N6_N4_Mtase; pfam01555
880072005355	Restriction endonuclease; Region: Mrr_cat; pfam04471
880072005356	2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659
880072005357	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
880072005358	dimer interface [polypeptide binding]; other site
880072005359	PYR/PP interface [polypeptide binding]; other site
880072005360	TPP binding site [chemical binding]; other site
880072005361	substrate binding site [chemical binding]; other site
880072005362	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
880072005363	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
880072005364	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
880072005365	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
880072005366	glutamine binding [chemical binding]; other site
880072005367	catalytic triad [active]
880072005368	anthranilate synthase component I; Provisional; Region: PRK13565
880072005369	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
880072005370	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
880072005371	CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640
880072005372	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
880072005373	P-loop; other site
880072005374	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
880072005375	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
880072005376	non-specific DNA binding site [nucleotide binding]; other site
880072005377	salt bridge; other site
880072005378	sequence-specific DNA binding site [nucleotide binding]; other site
880072005379	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
880072005380	CoenzymeA binding site [chemical binding]; other site
880072005381	subunit interaction site [polypeptide binding]; other site
880072005382	PHB binding site; other site
880072005383	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
880072005384	dimer interface [polypeptide binding]; other site
880072005385	catalytic triad [active]
880072005386	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
880072005387	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072005388	active site
880072005389	phosphorylation site [posttranslational modification]
880072005390	intermolecular recognition site; other site
880072005391	dimerization interface [polypeptide binding]; other site
880072005392	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
880072005393	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
880072005394	acyl-activating enzyme (AAE) consensus motif; other site
880072005395	AMP binding site [chemical binding]; other site
880072005396	active site
880072005397	CoA binding site [chemical binding]; other site
880072005398	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
880072005399	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
880072005400	Walker A/P-loop; other site
880072005401	ATP binding site [chemical binding]; other site
880072005402	Q-loop/lid; other site
880072005403	ABC transporter signature motif; other site
880072005404	Walker B; other site
880072005405	D-loop; other site
880072005406	H-loop/switch region; other site
880072005407	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
880072005408	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
880072005409	Walker A/P-loop; other site
880072005410	ATP binding site [chemical binding]; other site
880072005411	Q-loop/lid; other site
880072005412	ABC transporter signature motif; other site
880072005413	Walker B; other site
880072005414	D-loop; other site
880072005415	H-loop/switch region; other site
880072005416	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
880072005417	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
880072005418	TM-ABC transporter signature motif; other site
880072005419	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
880072005420	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
880072005421	TM-ABC transporter signature motif; other site
880072005422	Protein of unknown function (DUF3124); Region: DUF3124; pfam11322
880072005423	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
880072005424	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
880072005425	active site
880072005426	dimerization interface [polypeptide binding]; other site
880072005427	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
880072005428	Protein of unknown function DUF89; Region: DUF89; cl15397
880072005429	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
880072005430	glycoprotein BALF4; Provisional; Region: PHA03231
880072005431	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072005432	Walker A motif; other site
880072005433	ATP binding site [chemical binding]; other site
880072005434	Walker B motif; other site
880072005435	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
880072005436	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
880072005437	ThiF family; Region: ThiF; pfam00899
880072005438	ATP binding site [chemical binding]; other site
880072005439	substrate interface [chemical binding]; other site
880072005440	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
880072005441	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
880072005442	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
880072005443	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
880072005444	active site
880072005445	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
880072005446	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
880072005447	CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507
880072005448	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
880072005449	putative active site [active]
880072005450	catalytic triad [active]
880072005451	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
880072005452	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
880072005453	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
880072005454	Protein export membrane protein; Region: SecD_SecF; cl14618
880072005455	bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625
880072005456	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
880072005457	active site
880072005458	metal binding site [ion binding]; metal-binding site
880072005459	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
880072005460	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
880072005461	FeS/SAM binding site; other site
880072005462	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
880072005463	Part of AAA domain; Region: AAA_19; pfam13245
880072005464	Family description; Region: UvrD_C_2; pfam13538
880072005465	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
880072005466	active site
880072005467	SAM binding site [chemical binding]; other site
880072005468	homodimer interface [polypeptide binding]; other site
880072005469	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
880072005470	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
880072005471	active site
880072005472	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which  binds to Adenosine group; Region: Alpha_ANH_like; cd01986
880072005473	Ligand Binding Site [chemical binding]; other site
880072005474	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
880072005475	CoA binding domain; Region: CoA_binding; smart00881
880072005476	CoA-ligase; Region: Ligase_CoA; pfam00549
880072005477	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
880072005478	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
880072005479	CoA-ligase; Region: Ligase_CoA; pfam00549
880072005480	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
880072005481	Methyltransferase domain; Region: Methyltransf_23; pfam13489
880072005482	Methyltransferase domain; Region: Methyltransf_12; pfam08242
880072005483	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
880072005484	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
880072005485	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
880072005486	active site
880072005487	UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589
880072005488	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
880072005489	NAD(P) binding site [chemical binding]; other site
880072005490	homodimer interface [polypeptide binding]; other site
880072005491	substrate binding site [chemical binding]; other site
880072005492	active site
880072005493	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
880072005494	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
880072005495	inhibitor-cofactor binding pocket; inhibition site
880072005496	pyridoxal 5'-phosphate binding site [chemical binding]; other site
880072005497	catalytic residue [active]
880072005498	Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089
880072005499	NeuB family; Region: NeuB; pfam03102
880072005500	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
880072005501	NeuB binding interface [polypeptide binding]; other site
880072005502	putative substrate binding site [chemical binding]; other site
880072005503	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
880072005504	ligand binding site; other site
880072005505	tetramer interface; other site
880072005506	pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590
880072005507	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
880072005508	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
880072005509	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
880072005510	pseudaminic acid synthase; Region: PseI; TIGR03586
880072005511	NeuB family; Region: NeuB; pfam03102
880072005512	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
880072005513	NeuB binding interface [polypeptide binding]; other site
880072005514	putative substrate binding site [chemical binding]; other site
880072005515	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
880072005516	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
880072005517	putative active site [active]
880072005518	oxyanion strand; other site
880072005519	catalytic triad [active]
880072005520	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
880072005521	substrate binding site [chemical binding]; other site
880072005522	glutamase interaction surface [polypeptide binding]; other site
880072005523	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_III; cd01996
880072005524	Ligand Binding Site [chemical binding]; other site
880072005525	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
880072005526	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
880072005527	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
880072005528	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
880072005529	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
880072005530	Methyltransferase domain; Region: Methyltransf_23; pfam13489
880072005531	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072005532	S-adenosylmethionine binding site [chemical binding]; other site
880072005533	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
880072005534	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
880072005535	putative active site [active]
880072005536	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
880072005537	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
880072005538	putative active site [active]
880072005539	metal binding site [ion binding]; metal-binding site
880072005540	homodimer binding site [polypeptide binding]; other site
880072005541	phosphodiesterase; Provisional; Region: PRK12704
880072005542	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
880072005543	Zn2+ binding site [ion binding]; other site
880072005544	Mg2+ binding site [ion binding]; other site
880072005545	FeoA domain; Region: FeoA; pfam04023
880072005546	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
880072005547	metal binding site 2 [ion binding]; metal-binding site
880072005548	putative DNA binding helix; other site
880072005549	metal binding site 1 [ion binding]; metal-binding site
880072005550	dimer interface [polypeptide binding]; other site
880072005551	structural Zn2+ binding site [ion binding]; other site
880072005552	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
880072005553	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208
880072005554	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
880072005555	NAD(P) binding site [chemical binding]; other site
880072005556	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
880072005557	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
880072005558	SLBB domain; Region: SLBB; pfam10531
880072005559	SLBB domain; Region: SLBB; pfam10531
880072005560	SLBB domain; Region: SLBB; pfam10531
880072005561	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
880072005562	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
880072005563	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
880072005564	dimer interface [polypeptide binding]; other site
880072005565	ssDNA binding site [nucleotide binding]; other site
880072005566	tetramer (dimer of dimers) interface [polypeptide binding]; other site
880072005567	HEAT-like repeat; Region: HEAT_EZ; pfam13513
880072005568	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
880072005569	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
880072005570	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
880072005571	glutamate racemase; Provisional; Region: PRK00865
880072005572	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
880072005573	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
880072005574	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
880072005575	Walker A/P-loop; other site
880072005576	ATP binding site [chemical binding]; other site
880072005577	Q-loop/lid; other site
880072005578	ABC transporter signature motif; other site
880072005579	Walker B; other site
880072005580	D-loop; other site
880072005581	H-loop/switch region; other site
880072005582	Domain of unknown function (DUF389); Region: DUF389; pfam04087
880072005583	Bacterial SH3 domain; Region: SH3_3; cl17532
880072005584	Bacterial SH3 domain; Region: SH3_3; cl17532
880072005585	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
880072005586	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072005587	Walker A motif; other site
880072005588	ATP binding site [chemical binding]; other site
880072005589	Walker B motif; other site
880072005590	arginine finger; other site
880072005591	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
880072005592	Protein of unknown function (DUF1640); Region: DUF1640; pfam07798
880072005593	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
880072005594	Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667
880072005595	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
880072005596	oligomerisation interface [polypeptide binding]; other site
880072005597	mobile loop; other site
880072005598	roof hairpin; other site
880072005599	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
880072005600	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
880072005601	ring oligomerisation interface [polypeptide binding]; other site
880072005602	ATP/Mg binding site [chemical binding]; other site
880072005603	stacking interactions; other site
880072005604	hinge regions; other site
880072005605	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
880072005606	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
880072005607	active site
880072005608	FMN binding site [chemical binding]; other site
880072005609	substrate binding site [chemical binding]; other site
880072005610	3Fe-4S cluster binding site [ion binding]; other site
880072005611	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
880072005612	Protein of unknown function DUF86; Region: DUF86; cl01031
880072005613	Methyltransferase domain; Region: Methyltransf_31; pfam13847
880072005614	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072005615	S-adenosylmethionine binding site [chemical binding]; other site
880072005616	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
880072005617	AAA ATPase domain; Region: AAA_16; pfam13191
880072005618	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
880072005619	DNA-binding site [nucleotide binding]; DNA binding site
880072005620	RNA-binding motif; other site
880072005621	Tetratricopeptide repeat; Region: TPR_16; pfam13432
880072005622	Tetratricopeptide repeat; Region: TPR_16; pfam13432
880072005623	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072005624	binding surface
880072005625	TPR motif; other site
880072005626	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072005627	TPR motif; other site
880072005628	binding surface
880072005629	TPR repeat; Region: TPR_11; pfam13414
880072005630	Transposase domain (DUF772); Region: DUF772; pfam05598
880072005631	Predicted transcriptional regulator [Transcription]; Region: COG2378
880072005632	WYL domain; Region: WYL; pfam13280
880072005633	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
880072005634	IHF - DNA interface [nucleotide binding]; other site
880072005635	IHF dimer interface [polypeptide binding]; other site
880072005636	Uncharacterized conserved protein [Function unknown]; Region: COG2006
880072005637	Domain of unknown function (DUF362); Region: DUF362; pfam04015
880072005638	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
880072005639	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
880072005640	Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977
880072005641	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
880072005642	TadE-like protein; Region: TadE; pfam07811
880072005643	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
880072005644	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
880072005645	TPR repeat; Region: TPR_11; pfam13414
880072005646	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072005647	binding surface
880072005648	TPR motif; other site
880072005649	TPR repeat; Region: TPR_11; pfam13414
880072005650	TPR repeat; Region: TPR_11; pfam13414
880072005651	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072005652	TPR motif; other site
880072005653	binding surface
880072005654	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072005655	TPR repeat; Region: TPR_11; pfam13414
880072005656	TPR motif; other site
880072005657	binding surface
880072005658	TPR repeat; Region: TPR_11; pfam13414
880072005659	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072005660	TPR motif; other site
880072005661	binding surface
880072005662	Tetratricopeptide repeat; Region: TPR_16; pfam13432
880072005663	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
880072005664	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
880072005665	BON domain; Region: BON; pfam04972
880072005666	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
880072005667	Dodecin; Region: Dodecin; pfam07311
880072005668	RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204
880072005669	RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874
880072005670	putative active site [active]
880072005671	adenylation catalytic residue [active]
880072005672	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
880072005673	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
880072005674	PAS domain S-box; Region: sensory_box; TIGR00229
880072005675	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072005676	putative active site [active]
880072005677	heme pocket [chemical binding]; other site
880072005678	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072005679	Response regulator receiver domain; Region: Response_reg; pfam00072
880072005680	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072005681	active site
880072005682	phosphorylation site [posttranslational modification]
880072005683	intermolecular recognition site; other site
880072005684	dimerization interface [polypeptide binding]; other site
880072005685	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
880072005686	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
880072005687	putative acyl-acceptor binding pocket; other site
880072005688	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
880072005689	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
880072005690	dimer interface [polypeptide binding]; other site
880072005691	active site
880072005692	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293
880072005693	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
880072005694	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
880072005695	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
880072005696	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
880072005697	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
880072005698	putative acyl-acceptor binding pocket; other site
880072005699	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
880072005700	Na binding site [ion binding]; other site
880072005701	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
880072005702	GAF domain; Region: GAF_3; pfam13492
880072005703	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072005704	dimer interface [polypeptide binding]; other site
880072005705	phosphorylation site [posttranslational modification]
880072005706	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072005707	ATP binding site [chemical binding]; other site
880072005708	Mg2+ binding site [ion binding]; other site
880072005709	G-X-G motif; other site
880072005710	GAF domain; Region: GAF_2; pfam13185
880072005711	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
880072005712	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072005713	PAS domain; Region: PAS_9; pfam13426
880072005714	putative active site [active]
880072005715	heme pocket [chemical binding]; other site
880072005716	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
880072005717	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072005718	dimer interface [polypeptide binding]; other site
880072005719	phosphorylation site [posttranslational modification]
880072005720	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072005721	ATP binding site [chemical binding]; other site
880072005722	Mg2+ binding site [ion binding]; other site
880072005723	G-X-G motif; other site
880072005724	L-asparaginase II; Region: Asparaginase_II; pfam06089
880072005725	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
880072005726	nucleotide binding site/active site [active]
880072005727	HIT family signature motif; other site
880072005728	catalytic residue [active]
880072005729	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
880072005730	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
880072005731	N-terminal plug; other site
880072005732	ligand-binding site [chemical binding]; other site
880072005733	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
880072005734	MutS domain I; Region: MutS_I; pfam01624
880072005735	MutS domain II; Region: MutS_II; pfam05188
880072005736	MutS domain III; Region: MutS_III; pfam05192
880072005737	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
880072005738	Walker A/P-loop; other site
880072005739	ATP binding site [chemical binding]; other site
880072005740	Q-loop/lid; other site
880072005741	ABC transporter signature motif; other site
880072005742	Walker B; other site
880072005743	D-loop; other site
880072005744	H-loop/switch region; other site
880072005745	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
880072005746	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
880072005747	active site
880072005748	PHP Thumb interface [polypeptide binding]; other site
880072005749	metal binding site [ion binding]; metal-binding site
880072005750	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
880072005751	generic binding surface II; other site
880072005752	generic binding surface I; other site
880072005753	acetyl-CoA decarbonylase/synthase complex subunit delta; Provisional; Region: PRK04452
880072005754	carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702
880072005755	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
880072005756	ACS interaction site; other site
880072005757	CODH interaction site; other site
880072005758	metal cluster binding site [ion binding]; other site
880072005759	bifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta; Reviewed; Region: PRK09529
880072005760	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
880072005761	metal cluster binding site [ion binding]; other site
880072005762	CO dehydrogenase/acetyl-CoA synthase complex beta subunit; Region: CdhC; pfam03598
880072005763	acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional; Region: PRK04165
880072005764	Putative Fe-S cluster; Region: FeS; pfam04060
880072005765	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
880072005766	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
880072005767	substrate binding pocket [chemical binding]; other site
880072005768	dimer interface [polypeptide binding]; other site
880072005769	inhibitor binding site; inhibition site
880072005770	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
880072005771	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
880072005772	dimer interface [polypeptide binding]; other site
880072005773	active site
880072005774	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
880072005775	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
880072005776	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
880072005777	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
880072005778	Phosphoglycerate kinase; Region: PGK; pfam00162
880072005779	substrate binding site [chemical binding]; other site
880072005780	hinge regions; other site
880072005781	ADP binding site [chemical binding]; other site
880072005782	catalytic site [active]
880072005783	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
880072005784	triosephosphate isomerase; Provisional; Region: PRK14567
880072005785	substrate binding site [chemical binding]; other site
880072005786	dimer interface [polypeptide binding]; other site
880072005787	catalytic triad [active]
880072005788	Preprotein translocase SecG subunit; Region: SecG; pfam03840
880072005789	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
880072005790	Protein of unknown function (DUF1044); Region: DUF1044; pfam06296
880072005791	Predicted transcriptional regulator [Transcription]; Region: COG2944
880072005792	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
880072005793	non-specific DNA binding site [nucleotide binding]; other site
880072005794	salt bridge; other site
880072005795	sequence-specific DNA binding site [nucleotide binding]; other site
880072005796	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
880072005797	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
880072005798	active site
880072005799	substrate-binding site [chemical binding]; other site
880072005800	metal-binding site [ion binding]
880072005801	ATP binding site [chemical binding]; other site
880072005802	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
880072005803	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
880072005804	DNA binding residues [nucleotide binding]
880072005805	L-lactate permease; Region: Lactate_perm; cl00701
880072005806	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
880072005807	L-lactate permease; Region: Lactate_perm; cl00701
880072005808	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
880072005809	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
880072005810	Protein of unknown function (DUF2939); Region: DUF2939; pfam11159
880072005811	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
880072005812	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
880072005813	putative RNA binding site [nucleotide binding]; other site
880072005814	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072005815	DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453
880072005816	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
880072005817	dimerization interface [polypeptide binding]; other site
880072005818	putative DNA binding site [nucleotide binding]; other site
880072005819	putative Zn2+ binding site [ion binding]; other site
880072005820	4Fe-4S binding domain; Region: Fer4_5; pfam12801
880072005821	4Fe-4S binding domain; Region: Fer4_5; pfam12801
880072005822	Ferredoxin [Energy production and conversion]; Region: NapF; COG1145
880072005823	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
880072005824	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
880072005825	IHF dimer interface [polypeptide binding]; other site
880072005826	IHF - DNA interface [nucleotide binding]; other site
880072005827	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
880072005828	ABC-2 type transporter; Region: ABC2_membrane; cl17235
880072005829	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
880072005830	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
880072005831	Walker A/P-loop; other site
880072005832	ATP binding site [chemical binding]; other site
880072005833	Q-loop/lid; other site
880072005834	ABC transporter signature motif; other site
880072005835	Walker B; other site
880072005836	D-loop; other site
880072005837	H-loop/switch region; other site
880072005838	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
880072005839	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
880072005840	FeS/SAM binding site; other site
880072005841	GTP-binding protein YchF; Reviewed; Region: PRK09601
880072005842	YchF GTPase; Region: YchF; cd01900
880072005843	G1 box; other site
880072005844	GTP/Mg2+ binding site [chemical binding]; other site
880072005845	Switch I region; other site
880072005846	G2 box; other site
880072005847	Switch II region; other site
880072005848	G3 box; other site
880072005849	G4 box; other site
880072005850	G5 box; other site
880072005851	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
880072005852	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
880072005853	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
880072005854	active site
880072005855	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
880072005856	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
880072005857	active site
880072005858	nucleotide binding site [chemical binding]; other site
880072005859	HIGH motif; other site
880072005860	KMSKS motif; other site
880072005861	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
880072005862	active site
880072005863	catalytic triad [active]
880072005864	oxyanion hole [active]
880072005865	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
880072005866	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
880072005867	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072005868	S-adenosylmethionine binding site [chemical binding]; other site
880072005869	hypothetical protein; Validated; Region: PRK00110
880072005870	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
880072005871	active site
880072005872	putative DNA-binding cleft [nucleotide binding]; other site
880072005873	dimer interface [polypeptide binding]; other site
880072005874	Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14602
880072005875	RuvA N terminal domain; Region: RuvA_N; pfam01330
880072005876	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
880072005877	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
880072005878	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
880072005879	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
880072005880	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
880072005881	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
880072005882	acyl-activating enzyme (AAE) consensus motif; other site
880072005883	AMP binding site [chemical binding]; other site
880072005884	active site
880072005885	CoA binding site [chemical binding]; other site
880072005886	ACT domain-containing protein [General function prediction only]; Region: COG4747
880072005887	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
880072005888	C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882
880072005889	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
880072005890	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
880072005891	putative ligand binding site [chemical binding]; other site
880072005892	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
880072005893	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
880072005894	TM-ABC transporter signature motif; other site
880072005895	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
880072005896	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
880072005897	TM-ABC transporter signature motif; other site
880072005898	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
880072005899	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
880072005900	Walker A/P-loop; other site
880072005901	ATP binding site [chemical binding]; other site
880072005902	Q-loop/lid; other site
880072005903	ABC transporter signature motif; other site
880072005904	Walker B; other site
880072005905	D-loop; other site
880072005906	H-loop/switch region; other site
880072005907	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
880072005908	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
880072005909	Walker A/P-loop; other site
880072005910	ATP binding site [chemical binding]; other site
880072005911	Q-loop/lid; other site
880072005912	ABC transporter signature motif; other site
880072005913	Walker B; other site
880072005914	D-loop; other site
880072005915	H-loop/switch region; other site
880072005916	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
880072005917	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
880072005918	acyl-activating enzyme (AAE) consensus motif; other site
880072005919	active site
880072005920	AMP binding site [chemical binding]; other site
880072005921	CoA binding site [chemical binding]; other site
880072005922	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
880072005923	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
880072005924	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
880072005925	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
880072005926	putative active site [active]
880072005927	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
880072005928	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
880072005929	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
880072005930	active site
880072005931	cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200
880072005932	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294
880072005933	homoserine dehydrogenase; Provisional; Region: PRK06349
880072005934	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
880072005935	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
880072005936	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
880072005937	aminotransferase; Validated; Region: PRK08175
880072005938	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
880072005939	pyridoxal 5'-phosphate binding site [chemical binding]; other site
880072005940	homodimer interface [polypeptide binding]; other site
880072005941	catalytic residue [active]
880072005942	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
880072005943	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
880072005944	Protein of unknown function, DUF599; Region: DUF599; cl01575
880072005945	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
880072005946	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
880072005947	tRNA; other site
880072005948	putative tRNA binding site [nucleotide binding]; other site
880072005949	putative NADP binding site [chemical binding]; other site
880072005950	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
880072005951	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
880072005952	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
880072005953	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
880072005954	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
880072005955	homodimer interface [polypeptide binding]; other site
880072005956	chemical substrate binding site [chemical binding]; other site
880072005957	oligomer interface [polypeptide binding]; other site
880072005958	metal binding site [ion binding]; metal-binding site
880072005959	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
880072005960	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242
880072005961	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
880072005962	putative NAD(P) binding site [chemical binding]; other site
880072005963	catalytic Zn binding site [ion binding]; other site
880072005964	structural Zn binding site [ion binding]; other site
880072005965	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
880072005966	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
880072005967	Flagellin N-methylase; Region: FliB; cl00497
880072005968	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
880072005969	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
880072005970	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
880072005971	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
880072005972	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
880072005973	FeS/SAM binding site; other site
880072005974	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
880072005975	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
880072005976	Ligand Binding Site [chemical binding]; other site
880072005977	PilZ domain; Region: PilZ; pfam07238
880072005978	carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702
880072005979	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
880072005980	ACS interaction site; other site
880072005981	CODH interaction site; other site
880072005982	metal cluster binding site [ion binding]; other site
880072005983	Uncharacterized conserved protein [Function unknown]; Region: COG1262
880072005984	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
880072005985	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
880072005986	OstA-like protein; Region: OstA; cl00844
880072005987	Organic solvent tolerance protein; Region: OstA_C; pfam04453
880072005988	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
880072005989	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989
880072005990	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
880072005991	ATP binding site [chemical binding]; other site
880072005992	active site
880072005993	substrate binding site [chemical binding]; other site
880072005994	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
880072005995	Catalytic domain of Protein Kinases; Region: PKc; cd00180
880072005996	active site
880072005997	substrate binding site [chemical binding]; other site
880072005998	ATP binding site [chemical binding]; other site
880072005999	activation loop (A-loop); other site
880072006000	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072006001	binding surface
880072006002	TPR repeat; Region: TPR_11; pfam13414
880072006003	TPR motif; other site
880072006004	Tetratricopeptide repeat; Region: TPR_16; pfam13432
880072006005	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072006006	binding surface
880072006007	TPR repeat; Region: TPR_11; pfam13414
880072006008	TPR motif; other site
880072006009	Tetratricopeptide repeat; Region: TPR_16; pfam13432
880072006010	TPR repeat; Region: TPR_11; pfam13414
880072006011	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072006012	binding surface
880072006013	TPR motif; other site
880072006014	TPR repeat; Region: TPR_11; pfam13414
880072006015	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072006016	binding surface
880072006017	TPR repeat; Region: TPR_11; pfam13414
880072006018	TPR motif; other site
880072006019	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072006020	TPR motif; other site
880072006021	TPR repeat; Region: TPR_11; pfam13414
880072006022	binding surface
880072006023	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
880072006024	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
880072006025	catalytic triad [active]
880072006026	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
880072006027	Sulphur transport; Region: Sulf_transp; pfam04143
880072006028	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
880072006029	catalytic core [active]
880072006030	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
880072006031	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
880072006032	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
880072006033	active site
880072006034	Zn binding site [ion binding]; other site
880072006035	CHASE2 domain; Region: CHASE2; pfam05226
880072006036	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
880072006037	cyclase homology domain; Region: CHD; cd07302
880072006038	nucleotidyl binding site; other site
880072006039	metal binding site [ion binding]; metal-binding site
880072006040	dimer interface [polypeptide binding]; other site
880072006041	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
880072006042	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
880072006043	G1 box; other site
880072006044	putative GEF interaction site [polypeptide binding]; other site
880072006045	GTP/Mg2+ binding site [chemical binding]; other site
880072006046	Switch I region; other site
880072006047	G2 box; other site
880072006048	G3 box; other site
880072006049	Switch II region; other site
880072006050	G4 box; other site
880072006051	G5 box; other site
880072006052	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
880072006053	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
880072006054	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
880072006055	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
880072006056	Walker A/P-loop; other site
880072006057	ATP binding site [chemical binding]; other site
880072006058	Q-loop/lid; other site
880072006059	ABC transporter signature motif; other site
880072006060	Walker B; other site
880072006061	D-loop; other site
880072006062	H-loop/switch region; other site
880072006063	hypothetical protein; Provisional; Region: PRK04334
880072006064	EamA-like transporter family; Region: EamA; pfam00892
880072006065	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
880072006066	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
880072006067	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
880072006068	catalytic residue [active]
880072006069	sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; Region: ATPase-IIC_X-K; TIGR01106
880072006070	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
880072006071	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
880072006072	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
880072006073	Soluble P-type ATPase [General function prediction only]; Region: COG4087
880072006074	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
880072006075	Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792
880072006076	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
880072006077	putative cation:proton antiport protein; Provisional; Region: PRK10669
880072006078	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
880072006079	TrkA-N domain; Region: TrkA_N; pfam02254
880072006080	TrkA-C domain; Region: TrkA_C; pfam02080
880072006081	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
880072006082	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
880072006083	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
880072006084	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
880072006085	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
880072006086	Surface antigen; Region: Bac_surface_Ag; pfam01103
880072006087	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
880072006088	Family of unknown function (DUF490); Region: DUF490; pfam04357
880072006089	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
880072006090	Phosphotransferase enzyme family; Region: APH; pfam01636
880072006091	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
880072006092	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
880072006093	N-acetyl-D-glucosamine binding site [chemical binding]; other site
880072006094	catalytic residue [active]
880072006095	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
880072006096	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
880072006097	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
880072006098	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
880072006099	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
880072006100	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
880072006101	ATP binding site [chemical binding]; other site
880072006102	Walker A motif; other site
880072006103	hexamer interface [polypeptide binding]; other site
880072006104	Walker B motif; other site
880072006105	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
880072006106	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
880072006107	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
880072006108	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
880072006109	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
880072006110	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
880072006111	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
880072006112	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
880072006113	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
880072006114	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
880072006115	IHF dimer interface [polypeptide binding]; other site
880072006116	IHF - DNA interface [nucleotide binding]; other site
880072006117	CTP synthetase; Validated; Region: pyrG; PRK05380
880072006118	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
880072006119	Catalytic site [active]
880072006120	active site
880072006121	UTP binding site [chemical binding]; other site
880072006122	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
880072006123	active site
880072006124	putative oxyanion hole; other site
880072006125	catalytic triad [active]
880072006126	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
880072006127	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
880072006128	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
880072006129	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
880072006130	active site
880072006131	motif I; other site
880072006132	motif II; other site
880072006133	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
880072006134	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
880072006135	OstA-like protein; Region: OstA; pfam03968
880072006136	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
880072006137	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
880072006138	Walker A/P-loop; other site
880072006139	ATP binding site [chemical binding]; other site
880072006140	Q-loop/lid; other site
880072006141	ABC transporter signature motif; other site
880072006142	Walker B; other site
880072006143	D-loop; other site
880072006144	H-loop/switch region; other site
880072006145	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
880072006146	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
880072006147	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
880072006148	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
880072006149	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
880072006150	30S subunit binding site; other site
880072006151	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
880072006152	active site
880072006153	phosphorylation site [posttranslational modification]
880072006154	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
880072006155	AAA domain; Region: AAA_18; pfam13238
880072006156	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
880072006157	active pocket/dimerization site; other site
880072006158	active site
880072006159	phosphorylation site [posttranslational modification]
880072006160	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
880072006161	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
880072006162	Coenzyme A binding pocket [chemical binding]; other site
880072006163	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
880072006164	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
880072006165	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
880072006166	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
880072006167	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
880072006168	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
880072006169	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
880072006170	NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010
880072006171	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
880072006172	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
880072006173	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
880072006174	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
880072006175	4Fe-4S binding domain; Region: Fer4; pfam00037
880072006176	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
880072006177	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
880072006178	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
880072006179	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
880072006180	catalytic loop [active]
880072006181	iron binding site [ion binding]; other site
880072006182	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
880072006183	4Fe-4S binding domain; Region: Fer4; pfam00037
880072006184	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
880072006185	molybdopterin cofactor binding site; other site
880072006186	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
880072006187	molybdopterin cofactor binding site; other site
880072006188	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
880072006189	NADH dehydrogenase subunit D; Validated; Region: PRK06075
880072006190	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
880072006191	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
880072006192	NADH dehydrogenase subunit B; Validated; Region: PRK06411
880072006193	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
880072006194	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
880072006195	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
880072006196	putative dimer interface [polypeptide binding]; other site
880072006197	[2Fe-2S] cluster binding site [ion binding]; other site
880072006198	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
880072006199	SLBB domain; Region: SLBB; pfam10531
880072006200	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
880072006201	Fructose-1,6-bisphosphatase; Region: FBPase_3; pfam01950
880072006202	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
880072006203	homodimer interaction site [polypeptide binding]; other site
880072006204	cofactor binding site; other site
880072006205	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
880072006206	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
880072006207	Predicted RNA-binding protein; Region: RNA_bind_2; pfam10133
880072006208	Predicted AdoMet-dependent methyltransferase; Region: AdoMet_MTase; pfam07757
880072006209	Methyltransferase domain; Region: Methyltransf_31; pfam13847
880072006210	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072006211	S-adenosylmethionine binding site [chemical binding]; other site
880072006212	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
880072006213	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
880072006214	N-terminal plug; other site
880072006215	ligand-binding site [chemical binding]; other site
880072006216	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
880072006217	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
880072006218	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
880072006219	N-terminal plug; other site
880072006220	ligand-binding site [chemical binding]; other site
880072006221	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
880072006222	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
880072006223	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
880072006224	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
880072006225	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
880072006226	TolB amino-terminal domain; Region: TolB_N; pfam04052
880072006227	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
880072006228	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
880072006229	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
880072006230	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
880072006231	TonB C terminal; Region: TonB_2; pfam13103
880072006232	TolA protein; Region: tolA_full; TIGR02794
880072006233	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
880072006234	TolR protein; Region: tolR; TIGR02801
880072006235	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
880072006236	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
880072006237	CoenzymeA binding site [chemical binding]; other site
880072006238	subunit interaction site [polypeptide binding]; other site
880072006239	PHB binding site; other site
880072006240	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
880072006241	NifU-like domain; Region: NifU; pfam01106
880072006242	Uncharacterized conserved protein [Function unknown]; Region: COG2968
880072006243	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
880072006244	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
880072006245	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
880072006246	adenylosuccinate lyase; Provisional; Region: PRK07492
880072006247	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
880072006248	tetramer interface [polypeptide binding]; other site
880072006249	active site
880072006250	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
880072006251	GMP synthase; Reviewed; Region: guaA; PRK00074
880072006252	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
880072006253	AMP/PPi binding site [chemical binding]; other site
880072006254	candidate oxyanion hole; other site
880072006255	catalytic triad [active]
880072006256	potential glutamine specificity residues [chemical binding]; other site
880072006257	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
880072006258	ATP Binding subdomain [chemical binding]; other site
880072006259	Ligand Binding sites [chemical binding]; other site
880072006260	Dimerization subdomain; other site
880072006261	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
880072006262	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
880072006263	Walker A motif; other site
880072006264	ATP binding site [chemical binding]; other site
880072006265	ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470
880072006266	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
880072006267	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
880072006268	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
880072006269	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
880072006270	ATP-grasp domain; Region: ATP-grasp_4; cl17255
880072006271	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
880072006272	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
880072006273	ATP-grasp domain; Region: ATP-grasp_4; cl17255
880072006274	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
880072006275	IMP binding site; other site
880072006276	dimer interface [polypeptide binding]; other site
880072006277	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
880072006278	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
880072006279	active site
880072006280	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
880072006281	active site
880072006282	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
880072006283	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
880072006284	non-specific DNA binding site [nucleotide binding]; other site
880072006285	salt bridge; other site
880072006286	sequence-specific DNA binding site [nucleotide binding]; other site
880072006287	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
880072006288	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
880072006289	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
880072006290	Ligand Binding Site [chemical binding]; other site
880072006291	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
880072006292	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
880072006293	FeS/SAM binding site; other site
880072006294	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
880072006295	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
880072006296	P-loop; other site
880072006297	Magnesium ion binding site [ion binding]; other site
880072006298	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
880072006299	Magnesium ion binding site [ion binding]; other site
880072006300	pyrroline-5-carboxylate reductase; Region: PLN02688
880072006301	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
880072006302	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
880072006303	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
880072006304	dimerization interface [polypeptide binding]; other site
880072006305	active site
880072006306	spore photoproduct lyase; Region: photo_TT_lyase; cl15393
880072006307	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
880072006308	metal binding site 2 [ion binding]; metal-binding site
880072006309	putative DNA binding helix; other site
880072006310	metal binding site 1 [ion binding]; metal-binding site
880072006311	dimer interface [polypeptide binding]; other site
880072006312	structural Zn2+ binding site [ion binding]; other site
880072006313	Putative Fe-S cluster; Region: FeS; pfam04060
880072006314	Domain of unknown function (DUF3786); Region: DUF3786; pfam12654
880072006315	Ubiquitin-like proteins; Region: UBQ; cl00155
880072006316	hydrophobic patch; other site
880072006317	Rubrerythrin [Energy production and conversion]; Region: COG1592
880072006318	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
880072006319	binuclear metal center [ion binding]; other site
880072006320	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350
880072006321	iron binding site [ion binding]; other site
880072006322	desulfoferrodoxin; Region: dfx_rbo; TIGR00320
880072006323	Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974
880072006324	non-heme iron binding site [ion binding]; other site
880072006325	dimer interface [polypeptide binding]; other site
880072006326	Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin.  Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171
880072006327	non-heme iron binding site [ion binding]; other site
880072006328	dimer interface [polypeptide binding]; other site
880072006329	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
880072006330	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
880072006331	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
880072006332	dimer interface [polypeptide binding]; other site
880072006333	PYR/PP interface [polypeptide binding]; other site
880072006334	TPP binding site [chemical binding]; other site
880072006335	substrate binding site [chemical binding]; other site
880072006336	2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate family; Region: PorB_KorB; TIGR02177
880072006337	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
880072006338	TPP-binding site [chemical binding]; other site
880072006339	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
880072006340	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
880072006341	Rubredoxin; Region: Rubredoxin; pfam00301
880072006342	iron binding site [ion binding]; other site
880072006343	Rubredoxin [Energy production and conversion]; Region: COG1773
880072006344	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
880072006345	iron binding site [ion binding]; other site
880072006346	metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921
880072006347	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
880072006348	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
880072006349	DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023
880072006350	active site
880072006351	metal-binding site
880072006352	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
880072006353	Protein of unknown function, DUF488; Region: DUF488; pfam04343
880072006354	Protein of unknown function, DUF488; Region: DUF488; pfam04343
880072006355	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
880072006356	Walker B motif; other site
880072006357	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
880072006358	four helix bundle protein; Region: TIGR02436
880072006359	LexA repressor; Validated; Region: PRK00215
880072006360	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
880072006361	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
880072006362	Catalytic site [active]
880072006363	Bacterial SH3 domain; Region: SH3_3; cl17532
880072006364	Bacterial SH3 domain; Region: SH3_3; pfam08239
880072006365	aspartate aminotransferase; Provisional; Region: PRK05764
880072006366	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
880072006367	pyridoxal 5'-phosphate binding site [chemical binding]; other site
880072006368	homodimer interface [polypeptide binding]; other site
880072006369	catalytic residue [active]
880072006370	YacP-like NYN domain; Region: NYN_YacP; pfam05991
880072006371	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
880072006372	Double zinc ribbon; Region: DZR; pfam12773
880072006373	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
880072006374	Bacterial SH3 domain homologues; Region: SH3b; smart00287
880072006375	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
880072006376	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
880072006377	dimer interface [polypeptide binding]; other site
880072006378	active site
880072006379	CoA binding pocket [chemical binding]; other site
880072006380	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
880072006381	RmuC family; Region: RmuC; pfam02646
880072006382	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
880072006383	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
880072006384	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
880072006385	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
880072006386	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
880072006387	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
880072006388	Bacterial sugar transferase; Region: Bac_transf; pfam02397
880072006389	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
880072006390	exosortase D, VPLPA-CTERM-specific; Region: exosort_VPLPA; TIGR04152
880072006391	Protein of unknown function (DUF3485); Region: DUF3485; pfam11984
880072006392	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
880072006393	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
880072006394	active site
880072006395	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
880072006396	homodimer interface [polypeptide binding]; other site
880072006397	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
880072006398	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
880072006399	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
880072006400	trimer interface [polypeptide binding]; other site
880072006401	active site
880072006402	substrate binding site [chemical binding]; other site
880072006403	CoA binding site [chemical binding]; other site
880072006404	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
880072006405	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
880072006406	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
880072006407	catalytic residue [active]
880072006408	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
880072006409	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
880072006410	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
880072006411	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
880072006412	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
880072006413	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
880072006414	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
880072006415	active site
880072006416	AMP binding site [chemical binding]; other site
880072006417	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
880072006418	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
880072006419	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
880072006420	Right handed beta helix region; Region: Beta_helix; pfam13229
880072006421	Disaggregatase related; Region: Disaggr_assoc; pfam08480
880072006422	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
880072006423	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
880072006424	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
880072006425	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
880072006426	active site
880072006427	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
880072006428	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
880072006429	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
880072006430	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
880072006431	periplasmic folding chaperone; Provisional; Region: PRK10788
880072006432	SurA N-terminal domain; Region: SurA_N_3; cl07813
880072006433	PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616
880072006434	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
880072006435	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
880072006436	Tetratricopeptide repeat; Region: TPR_6; pfam13174
880072006437	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
880072006438	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
880072006439	ligand binding site [chemical binding]; other site
880072006440	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
880072006441	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
880072006442	FtsX-like permease family; Region: FtsX; pfam02687
880072006443	CAAX protease self-immunity; Region: Abi; pfam02517
880072006444	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
880072006445	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
880072006446	Walker A/P-loop; other site
880072006447	ATP binding site [chemical binding]; other site
880072006448	Q-loop/lid; other site
880072006449	ABC transporter signature motif; other site
880072006450	Walker B; other site
880072006451	D-loop; other site
880072006452	H-loop/switch region; other site
880072006453	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
880072006454	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
880072006455	HlyD family secretion protein; Region: HlyD_3; pfam13437
880072006456	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
880072006457	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
880072006458	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
880072006459	motif II; other site
880072006460	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
880072006461	active site residue [active]
880072006462	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
880072006463	CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514
880072006464	Uncharacterized conserved protein (DUF2149); Region: DUF2149; pfam09919
880072006465	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
880072006466	Predicted transporter (DUF2162); Region: DUF2162; cl01990
880072006467	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
880072006468	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
880072006469	N-terminal plug; other site
880072006470	ligand-binding site [chemical binding]; other site
880072006471	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
880072006472	active site
880072006473	SAM binding site [chemical binding]; other site
880072006474	homodimer interface [polypeptide binding]; other site
880072006475	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
880072006476	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
880072006477	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
880072006478	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
880072006479	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
880072006480	active site
880072006481	SAM binding site [chemical binding]; other site
880072006482	homodimer interface [polypeptide binding]; other site
880072006483	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
880072006484	active site
880072006485	putative homodimer interface [polypeptide binding]; other site
880072006486	SAM binding site [chemical binding]; other site
880072006487	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
880072006488	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072006489	S-adenosylmethionine binding site [chemical binding]; other site
880072006490	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
880072006491	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
880072006492	active site
880072006493	SAM binding site [chemical binding]; other site
880072006494	homodimer interface [polypeptide binding]; other site
880072006495	Precorrin-8X methylmutase; Region: CbiC; pfam02570
880072006496	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
880072006497	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
880072006498	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
880072006499	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
880072006500	catalytic triad [active]
880072006501	Cobalt chelatase (CbiK); Region: CbiK; pfam06180
880072006502	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
880072006503	active site
880072006504	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
880072006505	active site
880072006506	N-terminal domain interface [polypeptide binding]; other site
880072006507	cobalt transport protein CbiM; Validated; Region: PRK06265
880072006508	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
880072006509	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
880072006510	Cytochrome c; Region: Cytochrom_C; pfam00034
880072006511	CHASE2 domain; Region: CHASE2; pfam05226
880072006512	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
880072006513	cyclase homology domain; Region: CHD; cd07302
880072006514	nucleotidyl binding site; other site
880072006515	metal binding site [ion binding]; metal-binding site
880072006516	dimer interface [polypeptide binding]; other site
880072006517	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
880072006518	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
880072006519	active site
880072006520	metal binding site [ion binding]; metal-binding site
880072006521	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
880072006522	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
880072006523	active site
880072006524	Zn binding site [ion binding]; other site
880072006525	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
880072006526	CoA binding domain; Region: CoA_binding_2; pfam13380
880072006527	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
880072006528	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
880072006529	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
880072006530	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
880072006531	YcfA-like protein; Region: YcfA; pfam07927
880072006532	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
880072006533	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
880072006534	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
880072006535	salt bridge; other site
880072006536	non-specific DNA binding site [nucleotide binding]; other site
880072006537	sequence-specific DNA binding site [nucleotide binding]; other site
880072006538	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
880072006539	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
880072006540	catalytic residues [active]
880072006541	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
880072006542	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
880072006543	B12 binding site [chemical binding]; other site
880072006544	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
880072006545	FeS/SAM binding site; other site
880072006546	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
880072006547	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105
880072006548	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
880072006549	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
880072006550	homodimer interface [polypeptide binding]; other site
880072006551	oligonucleotide binding site [chemical binding]; other site
880072006552	Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276
880072006553	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
880072006554	G1 box; other site
880072006555	putative GEF interaction site [polypeptide binding]; other site
880072006556	GTP/Mg2+ binding site [chemical binding]; other site
880072006557	Switch I region; other site
880072006558	G2 box; other site
880072006559	G3 box; other site
880072006560	Switch II region; other site
880072006561	G4 box; other site
880072006562	G5 box; other site
880072006563	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
880072006564	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
880072006565	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
880072006566	Peptidase family M48; Region: Peptidase_M48; pfam01435
880072006567	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
880072006568	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
880072006569	tetramer interface [polypeptide binding]; other site
880072006570	active site
880072006571	Mg2+/Mn2+ binding site [ion binding]; other site
880072006572	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
880072006573	active site
880072006574	metal-binding site
880072006575	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
880072006576	phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297
880072006577	PYR/PP interface [polypeptide binding]; other site
880072006578	dimer interface [polypeptide binding]; other site
880072006579	TPP binding site [chemical binding]; other site
880072006580	Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371
880072006581	TPP-binding site; other site
880072006582	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
880072006583	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
880072006584	active site
880072006585	metal-binding site
880072006586	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
880072006587	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
880072006588	catalytic residue [active]
880072006589	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
880072006590	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723
880072006591	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
880072006592	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
880072006593	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
880072006594	putative acyl-acceptor binding pocket; other site
880072006595	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
880072006596	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072006597	S-adenosylmethionine binding site [chemical binding]; other site
880072006598	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14168
880072006599	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
880072006600	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
880072006601	homodimer interface [polypeptide binding]; other site
880072006602	NADP binding site [chemical binding]; other site
880072006603	substrate binding site [chemical binding]; other site
880072006604	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
880072006605	Hemerythrin-like domain; Region: Hr-like; cd12108
880072006606	Fe binding site [ion binding]; other site
880072006607	Patatin-like phospholipase; Region: Patatin; pfam01734
880072006608	active site
880072006609	nucleophile elbow; other site
880072006610	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
880072006611	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
880072006612	active site
880072006613	Riboflavin kinase; Region: Flavokinase; pfam01687
880072006614	ribosome maturation protein RimP; Reviewed; Region: PRK00092
880072006615	Sm and related proteins; Region: Sm_like; cl00259
880072006616	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
880072006617	putative oligomer interface [polypeptide binding]; other site
880072006618	putative RNA binding site [nucleotide binding]; other site
880072006619	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
880072006620	NusA N-terminal domain; Region: NusA_N; pfam08529
880072006621	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
880072006622	RNA binding site [nucleotide binding]; other site
880072006623	homodimer interface [polypeptide binding]; other site
880072006624	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
880072006625	G-X-X-G motif; other site
880072006626	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
880072006627	G-X-X-G motif; other site
880072006628	translation initiation factor IF-2; Region: IF-2; TIGR00487
880072006629	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
880072006630	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
880072006631	G1 box; other site
880072006632	putative GEF interaction site [polypeptide binding]; other site
880072006633	GTP/Mg2+ binding site [chemical binding]; other site
880072006634	Switch I region; other site
880072006635	G2 box; other site
880072006636	G3 box; other site
880072006637	Switch II region; other site
880072006638	G4 box; other site
880072006639	G5 box; other site
880072006640	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
880072006641	Translation-initiation factor 2; Region: IF-2; pfam11987
880072006642	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
880072006643	Protein of unknown function (DUF503); Region: DUF503; pfam04456
880072006644	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
880072006645	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
880072006646	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
880072006647	RNA binding site [nucleotide binding]; other site
880072006648	active site
880072006649	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
880072006650	16S/18S rRNA binding site [nucleotide binding]; other site
880072006651	S13e-L30e interaction site [polypeptide binding]; other site
880072006652	25S rRNA binding site [nucleotide binding]; other site
880072006653	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
880072006654	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
880072006655	RNase E interface [polypeptide binding]; other site
880072006656	trimer interface [polypeptide binding]; other site
880072006657	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
880072006658	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
880072006659	RNase E interface [polypeptide binding]; other site
880072006660	trimer interface [polypeptide binding]; other site
880072006661	active site
880072006662	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
880072006663	putative nucleic acid binding region [nucleotide binding]; other site
880072006664	G-X-X-G motif; other site
880072006665	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
880072006666	RNA binding site [nucleotide binding]; other site
880072006667	domain interface; other site
880072006668	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
880072006669	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
880072006670	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
880072006671	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
880072006672	PhoH-like protein; Region: PhoH; pfam02562
880072006673	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
880072006674	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
880072006675	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
880072006676	Zn2+ binding site [ion binding]; other site
880072006677	Mg2+ binding site [ion binding]; other site
880072006678	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
880072006679	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
880072006680	active site
880072006681	hydrophilic channel; other site
880072006682	dimerization interface [polypeptide binding]; other site
880072006683	catalytic residues [active]
880072006684	active site lid [active]
880072006685	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072006686	binding surface
880072006687	Tetratricopeptide repeat; Region: TPR_16; pfam13432
880072006688	TPR motif; other site
880072006689	TPR repeat; Region: TPR_11; pfam13414
880072006690	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072006691	binding surface
880072006692	TPR motif; other site
880072006693	heat shock protein HtpX; Provisional; Region: PRK03982
880072006694	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
880072006695	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072006696	dimer interface [polypeptide binding]; other site
880072006697	phosphorylation site [posttranslational modification]
880072006698	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072006699	ATP binding site [chemical binding]; other site
880072006700	Mg2+ binding site [ion binding]; other site
880072006701	G-X-G motif; other site
880072006702	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
880072006703	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
880072006704	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
880072006705	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
880072006706	dimer interface [polypeptide binding]; other site
880072006707	motif 1; other site
880072006708	active site
880072006709	motif 2; other site
880072006710	motif 3; other site
880072006711	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
880072006712	23S rRNA binding site [nucleotide binding]; other site
880072006713	L21 binding site [polypeptide binding]; other site
880072006714	L13 binding site [polypeptide binding]; other site
880072006715	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
880072006716	translation initiation factor IF-3; Region: infC; TIGR00168
880072006717	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
880072006718	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
880072006719	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
880072006720	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
880072006721	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
880072006722	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
880072006723	active site
880072006724	dimer interface [polypeptide binding]; other site
880072006725	motif 1; other site
880072006726	motif 2; other site
880072006727	motif 3; other site
880072006728	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
880072006729	anticodon binding site; other site
880072006730	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
880072006731	homodimer interaction site [polypeptide binding]; other site
880072006732	cofactor binding site; other site
880072006733	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
880072006734	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
880072006735	ATP binding site [chemical binding]; other site
880072006736	substrate interface [chemical binding]; other site
880072006737	Double zinc ribbon; Region: DZR; pfam12773
880072006738	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
880072006739	Bacterial SH3 domain homologues; Region: SH3b; smart00287
880072006740	LysE type translocator; Region: LysE; pfam01810
880072006741	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
880072006742	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
880072006743	Flavoprotein; Region: Flavoprotein; pfam02441
880072006744	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
880072006745	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
880072006746	Fe-S cluster binding site [ion binding]; other site
880072006747	active site
880072006748	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
880072006749	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
880072006750	dimer interface [polypeptide binding]; other site
880072006751	active site residues [active]
880072006752	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
880072006753	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
880072006754	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
880072006755	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
880072006756	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
880072006757	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
880072006758	ligand binding site [chemical binding]; other site
880072006759	flexible hinge region; other site
880072006760	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
880072006761	Methylamine utilisation protein MauE; Region: MauE; pfam07291
880072006762	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072006763	Response regulator receiver domain; Region: Response_reg; pfam00072
880072006764	active site
880072006765	phosphorylation site [posttranslational modification]
880072006766	intermolecular recognition site; other site
880072006767	dimerization interface [polypeptide binding]; other site
880072006768	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
880072006769	AAA domain; Region: AAA_30; pfam13604
880072006770	Family description; Region: UvrD_C_2; pfam13538
880072006771	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
880072006772	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
880072006773	HIT family signature motif; other site
880072006774	catalytic residue [active]
880072006775	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
880072006776	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
880072006777	homodimer interface [polypeptide binding]; other site
880072006778	substrate-cofactor binding pocket; other site
880072006779	pyridoxal 5'-phosphate binding site [chemical binding]; other site
880072006780	catalytic residue [active]
880072006781	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
880072006782	pyrophosphate-dependent phosphofructokinase; Region: PLN02251
880072006783	active site
880072006784	ADP/pyrophosphate binding site [chemical binding]; other site
880072006785	dimerization interface [polypeptide binding]; other site
880072006786	allosteric effector site; other site
880072006787	fructose-1,6-bisphosphate binding site; other site
880072006788	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
880072006789	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
880072006790	active site
880072006791	catalytic residues [active]
880072006792	metal binding site [ion binding]; metal-binding site
880072006793	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
880072006794	aspartate kinase; Reviewed; Region: PRK06635
880072006795	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
880072006796	putative nucleotide binding site [chemical binding]; other site
880072006797	putative catalytic residues [active]
880072006798	putative Mg ion binding site [ion binding]; other site
880072006799	putative aspartate binding site [chemical binding]; other site
880072006800	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
880072006801	putative allosteric regulatory site; other site
880072006802	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
880072006803	putative allosteric regulatory residue; other site
880072006804	hypothetical protein; Reviewed; Region: PRK00024
880072006805	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
880072006806	MPN+ (JAMM) motif; other site
880072006807	Zinc-binding site [ion binding]; other site
880072006808	TPR repeat; Region: TPR_11; pfam13414
880072006809	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072006810	binding surface
880072006811	TPR motif; other site
880072006812	TPR repeat; Region: TPR_11; pfam13414
880072006813	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072006814	binding surface
880072006815	Tetratricopeptide repeat; Region: TPR_16; pfam13432
880072006816	TPR motif; other site
880072006817	Protein of unknown function (DUF560); Region: DUF560; pfam04575
880072006818	FecR protein; Region: FecR; pfam04773
880072006819	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
880072006820	trimer interface [polypeptide binding]; other site
880072006821	putative Zn binding site [ion binding]; other site
880072006822	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
880072006823	AP endonuclease family 2; Region: AP2Ec; smart00518
880072006824	AP (apurinic/apyrimidinic) site pocket; other site
880072006825	DNA interaction; other site
880072006826	Metal-binding active site; metal-binding site
880072006827	Predicted permeases [General function prediction only]; Region: COG0795
880072006828	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
880072006829	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
880072006830	IHF - DNA interface [nucleotide binding]; other site
880072006831	IHF dimer interface [polypeptide binding]; other site
880072006832	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
880072006833	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
880072006834	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
880072006835	HlyD family secretion protein; Region: HlyD_3; pfam13437
880072006836	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
880072006837	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
880072006838	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
880072006839	putative dimer interface [polypeptide binding]; other site
880072006840	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
880072006841	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072006842	Walker A motif; other site
880072006843	ATP binding site [chemical binding]; other site
880072006844	Walker B motif; other site
880072006845	arginine finger; other site
880072006846	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
880072006847	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
880072006848	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
880072006849	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
880072006850	putative NAD(P) binding site [chemical binding]; other site
880072006851	active site
880072006852	UGMP family protein; Validated; Region: PRK09604
880072006853	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
880072006854	Recombination protein O N terminal; Region: RecO_N; pfam11967
880072006855	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
880072006856	Recombination protein O C terminal; Region: RecO_C; pfam02565
880072006857	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
880072006858	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
880072006859	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
880072006860	Smr domain; Region: Smr; pfam01713
880072006861	Peptidase family U32; Region: Peptidase_U32; pfam01136
880072006862	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
880072006863	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
880072006864	HSP70 interaction site [polypeptide binding]; other site
880072006865	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
880072006866	substrate binding site [polypeptide binding]; other site
880072006867	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
880072006868	Zn binding sites [ion binding]; other site
880072006869	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
880072006870	dimer interface [polypeptide binding]; other site
880072006871	Domain of unknown function DUF77; Region: DUF77; pfam01910
880072006872	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
880072006873	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072006874	active site
880072006875	phosphorylation site [posttranslational modification]
880072006876	intermolecular recognition site; other site
880072006877	dimerization interface [polypeptide binding]; other site
880072006878	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
880072006879	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
880072006880	Flavoprotein; Region: Flavoprotein; pfam02441
880072006881	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
880072006882	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
880072006883	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072006884	S-adenosylmethionine binding site [chemical binding]; other site
880072006885	M28 Zn-Peptidases; Region: M28_like_1; cd05640
880072006886	Peptidase family M28; Region: Peptidase_M28; pfam04389
880072006887	metal binding site [ion binding]; metal-binding site
880072006888	Flagellin N-methylase; Region: FliB; pfam03692
880072006889	Predicted integral membrane protein [Function unknown]; Region: COG5616
880072006890	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072006891	TPR motif; other site
880072006892	binding surface
880072006893	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072006894	TPR motif; other site
880072006895	binding surface
880072006896	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
880072006897	Permease; Region: Permease; pfam02405
880072006898	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
880072006899	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
880072006900	Walker A/P-loop; other site
880072006901	ATP binding site [chemical binding]; other site
880072006902	Q-loop/lid; other site
880072006903	ABC transporter signature motif; other site
880072006904	Walker B; other site
880072006905	D-loop; other site
880072006906	H-loop/switch region; other site
880072006907	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
880072006908	mce related protein; Region: MCE; pfam02470
880072006909	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
880072006910	Protein of unknown function (DUF330); Region: DUF330; pfam03886
880072006911	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
880072006912	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989
880072006913	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
880072006914	dimerization interface [polypeptide binding]; other site
880072006915	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
880072006916	cyclase homology domain; Region: CHD; cd07302
880072006917	nucleotidyl binding site; other site
880072006918	metal binding site [ion binding]; metal-binding site
880072006919	dimer interface [polypeptide binding]; other site
880072006920	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347
880072006921	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
880072006922	active site
880072006923	catalytic site [active]
880072006924	calcium/proton exchanger (cax); Region: cax; TIGR00378
880072006925	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
880072006926	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
880072006927	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
880072006928	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
880072006929	HlyD family secretion protein; Region: HlyD_3; pfam13437
880072006930	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
880072006931	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
880072006932	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
880072006933	Tropomyosin like; Region: Tropomyosin_1; pfam12718
880072006934	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072006935	dimer interface [polypeptide binding]; other site
880072006936	phosphorylation site [posttranslational modification]
880072006937	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072006938	ATP binding site [chemical binding]; other site
880072006939	Mg2+ binding site [ion binding]; other site
880072006940	G-X-G motif; other site
880072006941	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
880072006942	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072006943	active site
880072006944	phosphorylation site [posttranslational modification]
880072006945	intermolecular recognition site; other site
880072006946	dimerization interface [polypeptide binding]; other site
880072006947	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072006948	Walker A motif; other site
880072006949	ATP binding site [chemical binding]; other site
880072006950	Walker B motif; other site
880072006951	arginine finger; other site
880072006952	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
880072006953	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072006954	active site
880072006955	phosphorylation site [posttranslational modification]
880072006956	intermolecular recognition site; other site
880072006957	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
880072006958	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
880072006959	active site residue [active]
880072006960	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
880072006961	active site residue [active]
880072006962	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
880072006963	elongation factor G; Reviewed; Region: PRK12740
880072006964	G1 box; other site
880072006965	putative GEF interaction site [polypeptide binding]; other site
880072006966	GTP/Mg2+ binding site [chemical binding]; other site
880072006967	Switch I region; other site
880072006968	G2 box; other site
880072006969	G3 box; other site
880072006970	Switch II region; other site
880072006971	G4 box; other site
880072006972	G5 box; other site
880072006973	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
880072006974	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
880072006975	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
880072006976	MOSC domain; Region: MOSC; pfam03473
880072006977	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
880072006978	MPT binding site; other site
880072006979	trimer interface [polypeptide binding]; other site
880072006980	phosphoenolpyruvate synthase; Validated; Region: PRK06464
880072006981	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
880072006982	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
880072006983	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
880072006984	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
880072006985	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
880072006986	Zn2+ binding site [ion binding]; other site
880072006987	Mg2+ binding site [ion binding]; other site
880072006988	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
880072006989	synthetase active site [active]
880072006990	NTP binding site [chemical binding]; other site
880072006991	metal binding site [ion binding]; metal-binding site
880072006992	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
880072006993	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
880072006994	prolyl-tRNA synthetase; Provisional; Region: PRK09194
880072006995	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
880072006996	dimer interface [polypeptide binding]; other site
880072006997	motif 1; other site
880072006998	active site
880072006999	motif 2; other site
880072007000	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
880072007001	putative deacylase active site [active]
880072007002	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
880072007003	active site
880072007004	motif 3; other site
880072007005	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
880072007006	anticodon binding site; other site
880072007007	Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359
880072007008	RNase_H superfamily; Region: RNase_H_2; pfam13482
880072007009	active site
880072007010	substrate binding site [chemical binding]; other site
880072007011	catalytic site [active]
880072007012	TIGR03790 family protein; Region: TIGR03790
880072007013	TIGR03790 family protein; Region: TIGR03790
880072007014	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
880072007015	methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423
880072007016	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
880072007017	substrate binding site [chemical binding]; other site
880072007018	oxyanion hole (OAH) forming residues; other site
880072007019	trimer interface [polypeptide binding]; other site
880072007020	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
880072007021	DNA methylase; Region: N6_N4_Mtase; pfam01555
880072007022	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
880072007023	Putative addiction module component; Region: Unstab_antitox; pfam09720
880072007024	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
880072007025	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
880072007026	nucleotide binding pocket [chemical binding]; other site
880072007027	K-X-D-G motif; other site
880072007028	catalytic site [active]
880072007029	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
880072007030	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
880072007031	Helix-hairpin-helix motif; Region: HHH; pfam00633
880072007032	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
880072007033	Dimer interface [polypeptide binding]; other site
880072007034	Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254
880072007035	Response regulator receiver domain; Region: Response_reg; pfam00072
880072007036	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072007037	active site
880072007038	phosphorylation site [posttranslational modification]
880072007039	intermolecular recognition site; other site
880072007040	dimerization interface [polypeptide binding]; other site
880072007041	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
880072007042	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
880072007043	GAF domain; Region: GAF_3; pfam13492
880072007044	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
880072007045	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
880072007046	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072007047	dimer interface [polypeptide binding]; other site
880072007048	phosphorylation site [posttranslational modification]
880072007049	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072007050	ATP binding site [chemical binding]; other site
880072007051	Mg2+ binding site [ion binding]; other site
880072007052	G-X-G motif; other site
880072007053	glycogen synthase; Provisional; Region: glgA; PRK00654
880072007054	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
880072007055	ADP-binding pocket [chemical binding]; other site
880072007056	homodimer interface [polypeptide binding]; other site
880072007057	ADP-glucose phosphorylase; Region: PLN02643
880072007058	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
880072007059	dimer interface [polypeptide binding]; other site
880072007060	active site
880072007061	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
880072007062	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
880072007063	Quinolinate synthetase A protein; Region: NadA; pfam02445
880072007064	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
880072007065	Phage antirepressor protein KilAC domain; Region: ANT; cl01462
880072007066	Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731
880072007067	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
880072007068	FeS/SAM binding site; other site
880072007069	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
880072007070	putative DNA binding site [nucleotide binding]; other site
880072007071	putative Zn2+ binding site [ion binding]; other site
880072007072	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
880072007073	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
880072007074	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
880072007075	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855
880072007076	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
880072007077	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
880072007078	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
880072007079	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
880072007080	dimerization interface [polypeptide binding]; other site
880072007081	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
880072007082	ATP binding site [chemical binding]; other site
880072007083	Flagellin N-methylase; Region: FliB; pfam03692
880072007084	aspartate aminotransferase; Provisional; Region: PRK05764
880072007085	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
880072007086	pyridoxal 5'-phosphate binding site [chemical binding]; other site
880072007087	homodimer interface [polypeptide binding]; other site
880072007088	catalytic residue [active]
880072007089	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
880072007090	ATP-NAD kinase; Region: NAD_kinase; pfam01513
880072007091	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
880072007092	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
880072007093	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072007094	S-adenosylmethionine binding site [chemical binding]; other site
880072007095	Cache domain; Region: Cache_1; pfam02743
880072007096	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
880072007097	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
880072007098	dimerization interface [polypeptide binding]; other site
880072007099	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072007100	dimer interface [polypeptide binding]; other site
880072007101	phosphorylation site [posttranslational modification]
880072007102	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072007103	ATP binding site [chemical binding]; other site
880072007104	Mg2+ binding site [ion binding]; other site
880072007105	G-X-G motif; other site
880072007106	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
880072007107	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072007108	active site
880072007109	phosphorylation site [posttranslational modification]
880072007110	intermolecular recognition site; other site
880072007111	dimerization interface [polypeptide binding]; other site
880072007112	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072007113	Walker A motif; other site
880072007114	ATP binding site [chemical binding]; other site
880072007115	Walker B motif; other site
880072007116	arginine finger; other site
880072007117	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
880072007118	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
880072007119	DNA methylase; Region: N6_N4_Mtase; pfam01555
880072007120	Transposase IS200 like; Region: Y1_Tnp; cl00848
880072007121	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
880072007122	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
880072007123	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
880072007124	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
880072007125	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
880072007126	NAD(P) binding site [chemical binding]; other site
880072007127	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
880072007128	Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein).  Individual proteins of this band 7 domain family may...; Region: Band_7_prohibitin; cd03401
880072007129	Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574
880072007130	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
880072007131	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
880072007132	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822
880072007133	putative NAD(P) binding site [chemical binding]; other site
880072007134	putative substrate binding site [chemical binding]; other site
880072007135	catalytic Zn binding site [ion binding]; other site
880072007136	structural Zn binding site [ion binding]; other site
880072007137	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
880072007138	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
880072007139	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
880072007140	UbiA prenyltransferase family; Region: UbiA; pfam01040
880072007141	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
880072007142	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072007143	Walker A motif; other site
880072007144	ATP binding site [chemical binding]; other site
880072007145	Walker B motif; other site
880072007146	arginine finger; other site
880072007147	Peptidase family M41; Region: Peptidase_M41; pfam01434
880072007148	H+ Antiporter protein; Region: 2A0121; TIGR00900
880072007149	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
880072007150	putative substrate translocation pore; other site
880072007151	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14965
880072007152	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072007153	Walker A motif; other site
880072007154	ATP binding site [chemical binding]; other site
880072007155	Walker B motif; other site
880072007156	arginine finger; other site
880072007157	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
880072007158	hypothetical protein; Validated; Region: PRK00153
880072007159	recombination protein RecR; Reviewed; Region: recR; PRK00076
880072007160	RecR protein; Region: RecR; pfam02132
880072007161	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
880072007162	putative active site [active]
880072007163	putative metal-binding site [ion binding]; other site
880072007164	tetramer interface [polypeptide binding]; other site
880072007165	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
880072007166	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
880072007167	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
880072007168	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429
880072007169	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
880072007170	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
880072007171	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
880072007172	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
880072007173	beta subunit interaction interface [polypeptide binding]; other site
880072007174	Walker A motif; other site
880072007175	ATP binding site [chemical binding]; other site
880072007176	Walker B motif; other site
880072007177	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
880072007178	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
880072007179	core domain interface [polypeptide binding]; other site
880072007180	delta subunit interface [polypeptide binding]; other site
880072007181	epsilon subunit interface [polypeptide binding]; other site
880072007182	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
880072007183	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
880072007184	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
880072007185	alpha subunit interaction interface [polypeptide binding]; other site
880072007186	Walker A motif; other site
880072007187	ATP binding site [chemical binding]; other site
880072007188	Walker B motif; other site
880072007189	inhibitor binding site; inhibition site
880072007190	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
880072007191	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446
880072007192	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
880072007193	gamma subunit interface [polypeptide binding]; other site
880072007194	epsilon subunit interface [polypeptide binding]; other site
880072007195	LBP interface [polypeptide binding]; other site
880072007196	Condensation domain; Region: Condensation; pfam00668
880072007197	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
880072007198	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
880072007199	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
880072007200	acyl-activating enzyme (AAE) consensus motif; other site
880072007201	AMP binding site [chemical binding]; other site
880072007202	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
880072007203	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
880072007204	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
880072007205	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
880072007206	Substrate binding site; other site
880072007207	Mg++ binding site; other site
880072007208	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
880072007209	active site
880072007210	substrate binding site [chemical binding]; other site
880072007211	CoA binding site [chemical binding]; other site
880072007212	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
880072007213	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
880072007214	glutaminase active site [active]
880072007215	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
880072007216	dimer interface [polypeptide binding]; other site
880072007217	active site
880072007218	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
880072007219	dimer interface [polypeptide binding]; other site
880072007220	active site
880072007221	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
880072007222	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
880072007223	active site
880072007224	Smr domain; Region: Smr; pfam01713
880072007225	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
880072007226	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
880072007227	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
880072007228	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
880072007229	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
880072007230	putative catalytic site [active]
880072007231	putative metal binding site [ion binding]; other site
880072007232	putative phosphate binding site [ion binding]; other site
880072007233	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
880072007234	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
880072007235	Zn2+ binding site [ion binding]; other site
880072007236	Mg2+ binding site [ion binding]; other site
880072007237	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
880072007238	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
880072007239	DNA methylase; Region: N6_N4_Mtase; pfam01555
880072007240	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
880072007241	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
880072007242	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
880072007243	active site
880072007244	Int/Topo IB signature motif; other site
880072007245	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
880072007246	active site
880072007247	HslU subunit interaction site [polypeptide binding]; other site
880072007248	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
880072007249	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072007250	Walker A motif; other site
880072007251	ATP binding site [chemical binding]; other site
880072007252	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
880072007253	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
880072007254	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
880072007255	four helix bundle protein; Region: TIGR02436
880072007256	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
880072007257	feedback inhibition sensing region; other site
880072007258	homohexameric interface [polypeptide binding]; other site
880072007259	nucleotide binding site [chemical binding]; other site
880072007260	N-acetyl-L-glutamate binding site [chemical binding]; other site
880072007261	acetylornithine aminotransferase; Provisional; Region: PRK02627
880072007262	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
880072007263	inhibitor-cofactor binding pocket; inhibition site
880072007264	pyridoxal 5'-phosphate binding site [chemical binding]; other site
880072007265	catalytic residue [active]
880072007266	ornithine carbamoyltransferase; Provisional; Region: PRK00779
880072007267	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
880072007268	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
880072007269	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
880072007270	Ion channel; Region: Ion_trans_2; pfam07885
880072007271	argininosuccinate synthase; Provisional; Region: PRK13820
880072007272	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
880072007273	ANP binding site [chemical binding]; other site
880072007274	Substrate Binding Site II [chemical binding]; other site
880072007275	Substrate Binding Site I [chemical binding]; other site
880072007276	SdpI/YhfL protein family; Region: SdpI; pfam13630
880072007277	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
880072007278	argininosuccinate lyase; Provisional; Region: PRK00855
880072007279	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
880072007280	active sites [active]
880072007281	tetramer interface [polypeptide binding]; other site
880072007282	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
880072007283	Interdomain contacts; other site
880072007284	Cytokine receptor motif; other site
880072007285	diaminopimelate decarboxylase; Region: lysA; TIGR01048
880072007286	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
880072007287	active site
880072007288	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
880072007289	substrate binding site [chemical binding]; other site
880072007290	catalytic residues [active]
880072007291	dimer interface [polypeptide binding]; other site
880072007292	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
880072007293	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
880072007294	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
880072007295	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
880072007296	dihydrodipicolinate synthase; Region: dapA; TIGR00674
880072007297	dimer interface [polypeptide binding]; other site
880072007298	active site
880072007299	catalytic residue [active]
880072007300	dihydrodipicolinate reductase; Provisional; Region: PRK00048
880072007301	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
880072007302	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
880072007303	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
880072007304	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
880072007305	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
880072007306	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
880072007307	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
880072007308	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
880072007309	pyridoxal 5'-phosphate binding site [chemical binding]; other site
880072007310	homodimer interface [polypeptide binding]; other site
880072007311	catalytic residue [active]
880072007312	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
880072007313	catalytic center binding site [active]
880072007314	ATP binding site [chemical binding]; other site
880072007315	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
880072007316	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
880072007317	active site
880072007318	intersubunit interactions; other site
880072007319	catalytic residue [active]
880072007320	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
880072007321	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
880072007322	NAD(P) binding site [chemical binding]; other site
880072007323	catalytic residues [active]
880072007324	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
880072007325	non-specific DNA binding site [nucleotide binding]; other site
880072007326	salt bridge; other site
880072007327	sequence-specific DNA binding site [nucleotide binding]; other site
880072007328	Cupin domain; Region: Cupin_2; pfam07883
880072007329	flavodoxin; Provisional; Region: PRK06242
880072007330	CGGC domain; Region: CGGC; cl02356
880072007331	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
880072007332	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
880072007333	Walker A motif; other site
880072007334	ATP binding site [chemical binding]; other site
880072007335	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
880072007336	magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030
880072007337	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072007338	Walker A motif; other site
880072007339	ATP binding site [chemical binding]; other site
880072007340	Walker B motif; other site
880072007341	arginine finger; other site
880072007342	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
880072007343	metal ion-dependent adhesion site (MIDAS); other site
880072007344	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
880072007345	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
880072007346	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
880072007347	vitamin B12-transporter ATPase; Provisional; Region: PRK03695
880072007348	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
880072007349	Walker A/P-loop; other site
880072007350	ATP binding site [chemical binding]; other site
880072007351	Q-loop/lid; other site
880072007352	ABC transporter signature motif; other site
880072007353	Walker B; other site
880072007354	D-loop; other site
880072007355	H-loop/switch region; other site
880072007356	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
880072007357	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
880072007358	ABC-ATPase subunit  interface; other site
880072007359	dimer interface [polypeptide binding]; other site
880072007360	putative PBP binding regions; other site
880072007361	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
880072007362	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
880072007363	intersubunit interface [polypeptide binding]; other site
880072007364	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
880072007365	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
880072007366	N-terminal plug; other site
880072007367	ligand-binding site [chemical binding]; other site
880072007368	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
880072007369	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
880072007370	Walker A/P-loop; other site
880072007371	ATP binding site [chemical binding]; other site
880072007372	Q-loop/lid; other site
880072007373	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
880072007374	ABC transporter signature motif; other site
880072007375	Walker B; other site
880072007376	D-loop; other site
880072007377	H-loop/switch region; other site
880072007378	Domain of unknown function (DUF3786); Region: DUF3786; pfam12654
880072007379	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
880072007380	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
880072007381	Peptidase family U32; Region: Peptidase_U32; pfam01136
880072007382	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
880072007383	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
880072007384	substrate binding site [chemical binding]; other site
880072007385	glutamase interaction surface [polypeptide binding]; other site
880072007386	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
880072007387	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
880072007388	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
880072007389	GAF domain; Region: GAF; pfam01590
880072007390	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
880072007391	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
880072007392	metal binding site [ion binding]; metal-binding site
880072007393	active site
880072007394	I-site; other site
880072007395	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
880072007396	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
880072007397	putative active site [active]
880072007398	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
880072007399	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
880072007400	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
880072007401	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
880072007402	substrate binding site [chemical binding]; other site
880072007403	ligand binding site [chemical binding]; other site
880072007404	2-isopropylmalate synthase; Validated; Region: PRK00915
880072007405	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
880072007406	active site
880072007407	catalytic residues [active]
880072007408	metal binding site [ion binding]; metal-binding site
880072007409	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
880072007410	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
880072007411	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
880072007412	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
880072007413	ketol-acid reductoisomerase; Provisional; Region: PRK05479
880072007414	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
880072007415	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
880072007416	Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442
880072007417	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
880072007418	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
880072007419	putative valine binding site [chemical binding]; other site
880072007420	dimer interface [polypeptide binding]; other site
880072007421	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
880072007422	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
880072007423	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
880072007424	PYR/PP interface [polypeptide binding]; other site
880072007425	dimer interface [polypeptide binding]; other site
880072007426	TPP binding site [chemical binding]; other site
880072007427	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
880072007428	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
880072007429	TPP-binding site [chemical binding]; other site
880072007430	dimer interface [polypeptide binding]; other site
880072007431	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
880072007432	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
880072007433	This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110
880072007434	Ferredoxin [Energy production and conversion]; Region: COG1146
880072007435	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
880072007436	switch II; other site
880072007437	This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110
880072007438	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
880072007439	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
880072007440	switch II; other site
880072007441	Methyltransferase domain; Region: Methyltransf_31; pfam13847
880072007442	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072007443	S-adenosylmethionine binding site [chemical binding]; other site
880072007444	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
880072007445	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
880072007446	substrate binding site; other site
880072007447	tetramer interface; other site
880072007448	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
880072007449	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
880072007450	NAD(P) binding site [chemical binding]; other site
880072007451	active site
880072007452	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
880072007453	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
880072007454	ADP-ribose binding site [chemical binding]; other site
880072007455	dimer interface [polypeptide binding]; other site
880072007456	active site
880072007457	nudix motif; other site
880072007458	metal binding site [ion binding]; metal-binding site
880072007459	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
880072007460	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
880072007461	NAD binding site [chemical binding]; other site
880072007462	substrate binding site [chemical binding]; other site
880072007463	homodimer interface [polypeptide binding]; other site
880072007464	active site
880072007465	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
880072007466	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
880072007467	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
880072007468	NADP binding site [chemical binding]; other site
880072007469	active site
880072007470	putative substrate binding site [chemical binding]; other site
880072007471	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
880072007472	Ligand Binding Site [chemical binding]; other site
880072007473	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
880072007474	Ligand Binding Site [chemical binding]; other site
880072007475	Methyltransferase domain; Region: Methyltransf_31; pfam13847
880072007476	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072007477	S-adenosylmethionine binding site [chemical binding]; other site
880072007478	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072007479	S-adenosylmethionine binding site [chemical binding]; other site
880072007480	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
880072007481	Ligand Binding Site [chemical binding]; other site
880072007482	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
880072007483	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
880072007484	minor groove reading motif; other site
880072007485	helix-hairpin-helix signature motif; other site
880072007486	substrate binding pocket [chemical binding]; other site
880072007487	active site
880072007488	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
880072007489	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
880072007490	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
880072007491	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
880072007492	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
880072007493	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
880072007494	Predicted ATPase [General function prediction only]; Region: COG4637
880072007495	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
880072007496	Walker A/P-loop; other site
880072007497	ATP binding site [chemical binding]; other site
880072007498	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
880072007499	MgtC family; Region: MgtC; pfam02308
880072007500	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
880072007501	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
880072007502	ResB-like family; Region: ResB; pfam05140
880072007503	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
880072007504	lipoyl attachment site [posttranslational modification]; other site
880072007505	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
880072007506	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
880072007507	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
880072007508	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
880072007509	dimer interface [polypeptide binding]; other site
880072007510	PYR/PP interface [polypeptide binding]; other site
880072007511	TPP binding site [chemical binding]; other site
880072007512	substrate binding site [chemical binding]; other site
880072007513	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
880072007514	TPP-binding site; other site
880072007515	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
880072007516	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
880072007517	Putative exonuclease, RdgC; Region: RdgC; cl01122
880072007518	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
880072007519	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
880072007520	DNA binding site [nucleotide binding]
880072007521	catalytic residue [active]
880072007522	H2TH interface [polypeptide binding]; other site
880072007523	putative catalytic residues [active]
880072007524	turnover-facilitating residue; other site
880072007525	intercalation triad [nucleotide binding]; other site
880072007526	8OG recognition residue [nucleotide binding]; other site
880072007527	putative reading head residues; other site
880072007528	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
880072007529	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
880072007530	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
880072007531	replicative DNA helicase; Region: DnaB; TIGR00665
880072007532	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
880072007533	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
880072007534	Walker A motif; other site
880072007535	ATP binding site [chemical binding]; other site
880072007536	Walker B motif; other site
880072007537	DNA binding loops [nucleotide binding]
880072007538	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
880072007539	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
880072007540	substrate binding site [chemical binding]; other site
880072007541	ATP binding site [chemical binding]; other site
880072007542	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
880072007543	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
880072007544	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
880072007545	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
880072007546	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
880072007547	glutamine binding [chemical binding]; other site
880072007548	catalytic triad [active]
880072007549	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
880072007550	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
880072007551	active site
880072007552	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
880072007553	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
880072007554	active site
880072007555	catalytic motif [active]
880072007556	Zn binding site [ion binding]; other site
880072007557	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
880072007558	thiamine phosphate binding site [chemical binding]; other site
880072007559	active site
880072007560	pyrophosphate binding site [ion binding]; other site
880072007561	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
880072007562	substrate binding site [chemical binding]; other site
880072007563	multimerization interface [polypeptide binding]; other site
880072007564	ATP binding site [chemical binding]; other site
880072007565	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
880072007566	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
880072007567	active site
880072007568	HIGH motif; other site
880072007569	nucleotide binding site [chemical binding]; other site
880072007570	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
880072007571	KMSKS motif; other site
880072007572	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
880072007573	Protein of unknown function DUF86; Region: DUF86; cl01031
880072007574	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
880072007575	active site
880072007576	NTP binding site [chemical binding]; other site
880072007577	metal binding triad [ion binding]; metal-binding site
880072007578	antibiotic binding site [chemical binding]; other site
880072007579	hypothetical protein; Provisional; Region: PRK08609
880072007580	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
880072007581	active site
880072007582	primer binding site [nucleotide binding]; other site
880072007583	NTP  binding site [chemical binding]; other site
880072007584	metal binding triad [ion binding]; metal-binding site
880072007585	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
880072007586	active site
880072007587	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072007588	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
880072007589	putative active site [active]
880072007590	heme pocket [chemical binding]; other site
880072007591	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072007592	putative active site [active]
880072007593	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
880072007594	heme pocket [chemical binding]; other site
880072007595	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072007596	dimer interface [polypeptide binding]; other site
880072007597	phosphorylation site [posttranslational modification]
880072007598	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072007599	ATP binding site [chemical binding]; other site
880072007600	Mg2+ binding site [ion binding]; other site
880072007601	G-X-G motif; other site
880072007602	Response regulator receiver domain; Region: Response_reg; pfam00072
880072007603	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072007604	active site
880072007605	phosphorylation site [posttranslational modification]
880072007606	intermolecular recognition site; other site
880072007607	dimerization interface [polypeptide binding]; other site
880072007608	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
880072007609	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
880072007610	oligomer interface [polypeptide binding]; other site
880072007611	tandem repeat interface [polypeptide binding]; other site
880072007612	active site residues [active]
880072007613	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
880072007614	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
880072007615	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
880072007616	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
880072007617	recombination factor protein RarA; Reviewed; Region: PRK13342
880072007618	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072007619	Walker A motif; other site
880072007620	ATP binding site [chemical binding]; other site
880072007621	Walker B motif; other site
880072007622	arginine finger; other site
880072007623	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
880072007624	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
880072007625	active site
880072007626	putative substrate binding region [chemical binding]; other site
880072007627	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
880072007628	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
880072007629	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
880072007630	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
880072007631	inhibitor-cofactor binding pocket; inhibition site
880072007632	pyridoxal 5'-phosphate binding site [chemical binding]; other site
880072007633	catalytic residue [active]
880072007634	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
880072007635	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
880072007636	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
880072007637	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
880072007638	N-acetyl-D-glucosamine binding site [chemical binding]; other site
880072007639	catalytic residue [active]
880072007640	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
880072007641	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
880072007642	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
880072007643	active site
880072007644	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
880072007645	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
880072007646	putative ADP-binding pocket [chemical binding]; other site
880072007647	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
880072007648	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
880072007649	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
880072007650	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
880072007651	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
880072007652	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
880072007653	The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, Niemann-Pick type C2 (Npc2) protein, phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP), mite allergen Der p 2  and several proteins of...; Region: ML; cl00274
880072007654	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
880072007655	putative RNA binding site [nucleotide binding]; other site
880072007656	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
880072007657	homopentamer interface [polypeptide binding]; other site
880072007658	active site
880072007659	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
880072007660	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
880072007661	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
880072007662	dimerization interface [polypeptide binding]; other site
880072007663	active site
880072007664	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
880072007665	Lumazine binding domain; Region: Lum_binding; pfam00677
880072007666	Lumazine binding domain; Region: Lum_binding; pfam00677
880072007667	Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972
880072007668	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
880072007669	active site
880072007670	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
880072007671	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
880072007672	homodimer interface [polypeptide binding]; other site
880072007673	metal binding site [ion binding]; metal-binding site
880072007674	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
880072007675	homodimer interface [polypeptide binding]; other site
880072007676	active site
880072007677	putative chemical substrate binding site [chemical binding]; other site
880072007678	metal binding site [ion binding]; metal-binding site
880072007679	Colicin V production protein; Region: Colicin_V; pfam02674
880072007680	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072007681	TPR repeat; Region: TPR_11; pfam13414
880072007682	TPR motif; other site
880072007683	binding surface
880072007684	thymidylate synthase, methanogen type; Region: thy_syn_methano; TIGR03283
880072007685	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
880072007686	HEPN domain; Region: HEPN; pfam05168
880072007687	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
880072007688	active site
880072007689	NTP binding site [chemical binding]; other site
880072007690	metal binding triad [ion binding]; metal-binding site
880072007691	antibiotic binding site [chemical binding]; other site
880072007692	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
880072007693	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
880072007694	active site
880072007695	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
880072007696	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
880072007697	Walker A/P-loop; other site
880072007698	ATP binding site [chemical binding]; other site
880072007699	Q-loop/lid; other site
880072007700	ABC transporter signature motif; other site
880072007701	Walker B; other site
880072007702	D-loop; other site
880072007703	H-loop/switch region; other site
880072007704	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
880072007705	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
880072007706	Walker A/P-loop; other site
880072007707	ATP binding site [chemical binding]; other site
880072007708	Q-loop/lid; other site
880072007709	ABC transporter signature motif; other site
880072007710	Walker B; other site
880072007711	D-loop; other site
880072007712	H-loop/switch region; other site
880072007713	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
880072007714	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
880072007715	dimer interface [polypeptide binding]; other site
880072007716	conserved gate region; other site
880072007717	putative PBP binding loops; other site
880072007718	ABC-ATPase subunit interface; other site
880072007719	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
880072007720	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
880072007721	dimer interface [polypeptide binding]; other site
880072007722	conserved gate region; other site
880072007723	putative PBP binding loops; other site
880072007724	ABC-ATPase subunit interface; other site
880072007725	PBP superfamily domain; Region: PBP_like_2; cl17296
880072007726	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
880072007727	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
880072007728	PhoU domain; Region: PhoU; pfam01895
880072007729	PhoU domain; Region: PhoU; pfam01895
880072007730	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
880072007731	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072007732	active site
880072007733	phosphorylation site [posttranslational modification]
880072007734	intermolecular recognition site; other site
880072007735	dimerization interface [polypeptide binding]; other site
880072007736	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
880072007737	DNA binding site [nucleotide binding]
880072007738	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
880072007739	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072007740	putative active site [active]
880072007741	heme pocket [chemical binding]; other site
880072007742	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072007743	dimer interface [polypeptide binding]; other site
880072007744	phosphorylation site [posttranslational modification]
880072007745	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072007746	ATP binding site [chemical binding]; other site
880072007747	Mg2+ binding site [ion binding]; other site
880072007748	G-X-G motif; other site
880072007749	PBP superfamily domain; Region: PBP_like_2; cl17296
880072007750	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
880072007751	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
880072007752	dimer interface [polypeptide binding]; other site
880072007753	conserved gate region; other site
880072007754	ABC-ATPase subunit interface; other site
880072007755	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
880072007756	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
880072007757	dimer interface [polypeptide binding]; other site
880072007758	conserved gate region; other site
880072007759	putative PBP binding loops; other site
880072007760	ABC-ATPase subunit interface; other site
880072007761	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
880072007762	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
880072007763	Walker A/P-loop; other site
880072007764	ATP binding site [chemical binding]; other site
880072007765	Q-loop/lid; other site
880072007766	ABC transporter signature motif; other site
880072007767	Walker B; other site
880072007768	D-loop; other site
880072007769	H-loop/switch region; other site
880072007770	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
880072007771	PhoU domain; Region: PhoU; pfam01895
880072007772	PhoU domain; Region: PhoU; pfam01895
880072007773	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
880072007774	Glucose inhibited division protein A; Region: GIDA; pfam01134
880072007775	DNA topoisomerase I; Validated; Region: PRK06599
880072007776	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
880072007777	active site
880072007778	interdomain interaction site; other site
880072007779	putative metal-binding site [ion binding]; other site
880072007780	nucleotide binding site [chemical binding]; other site
880072007781	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
880072007782	domain I; other site
880072007783	DNA binding groove [nucleotide binding]
880072007784	phosphate binding site [ion binding]; other site
880072007785	domain II; other site
880072007786	domain III; other site
880072007787	nucleotide binding site [chemical binding]; other site
880072007788	catalytic site [active]
880072007789	domain IV; other site
880072007790	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
880072007791	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
880072007792	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
880072007793	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
880072007794	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
880072007795	DNA protecting protein DprA; Region: dprA; TIGR00732
880072007796	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
880072007797	G1 box; other site
880072007798	GTP/Mg2+ binding site [chemical binding]; other site
880072007799	G2 box; other site
880072007800	Switch I region; other site
880072007801	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
880072007802	G3 box; other site
880072007803	Switch II region; other site
880072007804	G5 box; other site
880072007805	Preprotein translocase subunit; Region: YajC; pfam02699
880072007806	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
880072007807	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
880072007808	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
880072007809	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
880072007810	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
880072007811	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
880072007812	inhibitor-cofactor binding pocket; inhibition site
880072007813	pyridoxal 5'-phosphate binding site [chemical binding]; other site
880072007814	catalytic residue [active]
880072007815	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
880072007816	active site
880072007817	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
880072007818	homodimer interface [polypeptide binding]; other site
880072007819	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
880072007820	Chain length determinant protein; Region: Wzz; pfam02706
880072007821	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
880072007822	Bacterial sugar transferase; Region: Bac_transf; pfam02397
880072007823	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
880072007824	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
880072007825	NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426
880072007826	Substrate binding site; other site
880072007827	metal-binding site
880072007828	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
880072007829	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
880072007830	NAD(P) binding site [chemical binding]; other site
880072007831	homodimer interface [polypeptide binding]; other site
880072007832	substrate binding site [chemical binding]; other site
880072007833	active site
880072007834	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
880072007835	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
880072007836	NAD(P) binding site [chemical binding]; other site
880072007837	active site
880072007838	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
880072007839	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
880072007840	active site
880072007841	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
880072007842	homodimer interface [polypeptide binding]; other site
880072007843	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
880072007844	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
880072007845	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
880072007846	active site
880072007847	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
880072007848	dimer interface [polypeptide binding]; other site
880072007849	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
880072007850	Ligand Binding Site [chemical binding]; other site
880072007851	Molecular Tunnel; other site
880072007852	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
880072007853	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
880072007854	Coenzyme A binding pocket [chemical binding]; other site
880072007855	putative glycosyl transferase; Provisional; Region: PRK10307
880072007856	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
880072007857	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
880072007858	Radical SAM superfamily; Region: Radical_SAM; pfam04055
880072007859	FeS/SAM binding site; other site
880072007860	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
880072007861	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
880072007862	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
880072007863	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
880072007864	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
880072007865	The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514
880072007866	peptide binding site [polypeptide binding]; other site
880072007867	Predicted metal-binding protein [Function unknown]; Region: COG5561
880072007868	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
880072007869	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
880072007870	TPP-binding site [chemical binding]; other site
880072007871	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
880072007872	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
880072007873	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
880072007874	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
880072007875	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
880072007876	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
880072007877	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
880072007878	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
880072007879	active site
880072007880	ribulose/triose binding site [chemical binding]; other site
880072007881	phosphate binding site [ion binding]; other site
880072007882	substrate (anthranilate) binding pocket [chemical binding]; other site
880072007883	product (indole) binding pocket [chemical binding]; other site
880072007884	DsrE/DsrF-like family; Region: DrsE; pfam02635
880072007885	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
880072007886	active site
880072007887	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
880072007888	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
880072007889	pyridoxal 5'-phosphate binding site [chemical binding]; other site
880072007890	catalytic residue [active]
880072007891	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
880072007892	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
880072007893	substrate binding site [chemical binding]; other site
880072007894	active site
880072007895	catalytic residues [active]
880072007896	heterodimer interface [polypeptide binding]; other site
880072007897	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
880072007898	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
880072007899	shikimate kinase; Reviewed; Region: aroK; PRK00131
880072007900	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
880072007901	ADP binding site [chemical binding]; other site
880072007902	magnesium binding site [ion binding]; other site
880072007903	putative shikimate binding site; other site
880072007904	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
880072007905	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
880072007906	Tetramer interface [polypeptide binding]; other site
880072007907	active site
880072007908	FMN-binding site [chemical binding]; other site
880072007909	arogenate dehydrogenase; Region: PLN02256
880072007910	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
880072007911	seryl-tRNA synthetase; Provisional; Region: PRK05431
880072007912	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
880072007913	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
880072007914	dimer interface [polypeptide binding]; other site
880072007915	active site
880072007916	motif 1; other site
880072007917	motif 2; other site
880072007918	motif 3; other site
880072007919	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
880072007920	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
880072007921	N-acetyl-D-glucosamine binding site [chemical binding]; other site
880072007922	catalytic residue [active]
880072007923	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
880072007924	Domain of unknown function DUF20; Region: UPF0118; pfam01594
880072007925	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
880072007926	putative acyl-acceptor binding pocket; other site
880072007927	Domain of unknown function (DUF1992); Region: DUF1992; cl08096
880072007928	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
880072007929	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
880072007930	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
880072007931	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
880072007932	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
880072007933	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
880072007934	active site
880072007935	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
880072007936	L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235
880072007937	putative NAD(P) binding site [chemical binding]; other site
880072007938	catalytic Zn binding site [ion binding]; other site
880072007939	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
880072007940	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
880072007941	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
880072007942	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
880072007943	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072007944	active site
880072007945	phosphorylation site [posttranslational modification]
880072007946	intermolecular recognition site; other site
880072007947	dimerization interface [polypeptide binding]; other site
880072007948	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072007949	Walker A motif; other site
880072007950	ATP binding site [chemical binding]; other site
880072007951	Walker B motif; other site
880072007952	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
880072007953	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
880072007954	potassium uptake protein; Region: kup; TIGR00794
880072007955	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
880072007956	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
880072007957	Ligand Binding Site [chemical binding]; other site
880072007958	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
880072007959	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
880072007960	dimerization interface [polypeptide binding]; other site
880072007961	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
880072007962	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072007963	dimer interface [polypeptide binding]; other site
880072007964	phosphorylation site [posttranslational modification]
880072007965	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072007966	ATP binding site [chemical binding]; other site
880072007967	Mg2+ binding site [ion binding]; other site
880072007968	G-X-G motif; other site
880072007969	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
880072007970	Domain of unknown function (DUF4410); Region: DUF4410; pfam14366
880072007971	glycogen branching enzyme; Provisional; Region: PRK12313
880072007972	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
880072007973	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
880072007974	active site
880072007975	catalytic site [active]
880072007976	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
880072007977	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
880072007978	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
880072007979	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
880072007980	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
880072007981	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
880072007982	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
880072007983	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
880072007984	DNA binding residues [nucleotide binding]
880072007985	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
880072007986	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
880072007987	generic binding surface II; other site
880072007988	generic binding surface I; other site
880072007989	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
880072007990	Zn2+ binding site [ion binding]; other site
880072007991	Mg2+ binding site [ion binding]; other site
880072007992	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
880072007993	Ligand Binding Site [chemical binding]; other site
880072007994	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
880072007995	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
880072007996	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
880072007997	active site
880072007998	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
880072007999	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
880072008000	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
880072008001	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
880072008002	trimer interface [polypeptide binding]; other site
880072008003	active site
880072008004	UDP-GlcNAc binding site [chemical binding]; other site
880072008005	lipid binding site [chemical binding]; lipid-binding site
880072008006	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
880072008007	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
880072008008	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
880072008009	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
880072008010	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
880072008011	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
880072008012	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
880072008013	Surface antigen; Region: Bac_surface_Ag; pfam01103
880072008014	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
880072008015	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
880072008016	Walker A/P-loop; other site
880072008017	ATP binding site [chemical binding]; other site
880072008018	Q-loop/lid; other site
880072008019	ABC transporter signature motif; other site
880072008020	Walker B; other site
880072008021	D-loop; other site
880072008022	H-loop/switch region; other site
880072008023	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
880072008024	FtsX-like permease family; Region: FtsX; pfam02687
880072008025	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
880072008026	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
880072008027	dimer interface [polypeptide binding]; other site
880072008028	putative anticodon binding site; other site
880072008029	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
880072008030	motif 1; other site
880072008031	active site
880072008032	motif 2; other site
880072008033	motif 3; other site
880072008034	DPS-like protein, ferritin-like diiron-binding domain; Region: DPSL; cd01052
880072008035	Ferritin-like domain; Region: Ferritin; pfam00210
880072008036	diiron binding motif [ion binding]; other site
880072008037	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
880072008038	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
880072008039	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
880072008040	4Fe-4S binding domain; Region: Fer4; cl02805
880072008041	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
880072008042	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
880072008043	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
880072008044	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
880072008045	Ligand Binding Site [chemical binding]; other site
880072008046	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
880072008047	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
880072008048	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
880072008049	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
880072008050	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
880072008051	CoA binding domain; Region: CoA_binding_2; pfam13380
880072008052	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
880072008053	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
880072008054	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
880072008055	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
880072008056	Coenzyme A binding pocket [chemical binding]; other site
880072008057	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
880072008058	Coenzyme A binding pocket [chemical binding]; other site
880072008059	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
880072008060	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
880072008061	ATP binding site [chemical binding]; other site
880072008062	putative Mg++ binding site [ion binding]; other site
880072008063	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
880072008064	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
880072008065	nucleotide binding region [chemical binding]; other site
880072008066	ATP-binding site [chemical binding]; other site
880072008067	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
880072008068	heterotetramer interface [polypeptide binding]; other site
880072008069	active site pocket [active]
880072008070	cleavage site
880072008071	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
880072008072	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
880072008073	TPR repeat; Region: TPR_11; pfam13414
880072008074	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072008075	binding surface
880072008076	TPR motif; other site
880072008077	TPR repeat; Region: TPR_11; pfam13414
880072008078	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
880072008079	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
880072008080	Permease; Region: Permease; pfam02405
880072008081	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
880072008082	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
880072008083	Walker A/P-loop; other site
880072008084	ATP binding site [chemical binding]; other site
880072008085	Q-loop/lid; other site
880072008086	ABC transporter signature motif; other site
880072008087	Walker B; other site
880072008088	D-loop; other site
880072008089	H-loop/switch region; other site
880072008090	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
880072008091	mce related protein; Region: MCE; pfam02470
880072008092	Protein of unknown function (DUF330); Region: DUF330; cl01135
880072008093	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
880072008094	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
880072008095	GAF domain; Region: GAF; pfam01590
880072008096	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
880072008097	GAF domain; Region: GAF; pfam01590
880072008098	enolase; Provisional; Region: eno; PRK00077
880072008099	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
880072008100	dimer interface [polypeptide binding]; other site
880072008101	metal binding site [ion binding]; metal-binding site
880072008102	substrate binding pocket [chemical binding]; other site
880072008103	Major Facilitator Superfamily; Region: MFS_1; pfam07690
880072008104	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
880072008105	putative substrate translocation pore; other site
880072008106	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
880072008107	Ligand Binding Site [chemical binding]; other site
880072008108	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
880072008109	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
880072008110	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
880072008111	FOG: CBS domain [General function prediction only]; Region: COG0517
880072008112	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
880072008113	FOG: CBS domain [General function prediction only]; Region: COG0517
880072008114	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
880072008115	FOG: CBS domain [General function prediction only]; Region: COG0517
880072008116	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
880072008117	camphor resistance protein CrcB; Provisional; Region: PRK14212
880072008118	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
880072008119	Dynamin family; Region: Dynamin_N; pfam00350
880072008120	G1 box; other site
880072008121	GTP/Mg2+ binding site [chemical binding]; other site
880072008122	G2 box; other site
880072008123	Switch I region; other site
880072008124	G3 box; other site
880072008125	Switch II region; other site
880072008126	G4 box; other site
880072008127	G5 box; other site
880072008128	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
880072008129	catalytic core [active]
880072008130	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
880072008131	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
880072008132	motif 1; other site
880072008133	active site
880072008134	motif 2; other site
880072008135	motif 3; other site
880072008136	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
880072008137	recombinase A; Provisional; Region: recA; PRK09354
880072008138	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
880072008139	hexamer interface [polypeptide binding]; other site
880072008140	Walker A motif; other site
880072008141	ATP binding site [chemical binding]; other site
880072008142	Walker B motif; other site
880072008143	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
880072008144	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
880072008145	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
880072008146	competence damage-inducible protein A; Provisional; Region: PRK00549
880072008147	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
880072008148	putative MPT binding site; other site
880072008149	Competence-damaged protein; Region: CinA; pfam02464
880072008150	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
880072008151	tetramer interfaces [polypeptide binding]; other site
880072008152	binuclear metal-binding site [ion binding]; other site
880072008153	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
880072008154	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
880072008155	putative active site [active]
880072008156	catalytic triad [active]
880072008157	putative dimer interface [polypeptide binding]; other site
880072008158	GTPase Era; Reviewed; Region: era; PRK00089
880072008159	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
880072008160	G1 box; other site
880072008161	GTP/Mg2+ binding site [chemical binding]; other site
880072008162	Switch I region; other site
880072008163	G2 box; other site
880072008164	Switch II region; other site
880072008165	G3 box; other site
880072008166	G4 box; other site
880072008167	G5 box; other site
880072008168	KH domain; Region: KH_2; pfam07650
880072008169	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
880072008170	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072008171	dimer interface [polypeptide binding]; other site
880072008172	phosphorylation site [posttranslational modification]
880072008173	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072008174	ATP binding site [chemical binding]; other site
880072008175	Mg2+ binding site [ion binding]; other site
880072008176	G-X-G motif; other site
880072008177	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
880072008178	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
880072008179	homodimer interface [polypeptide binding]; other site
880072008180	substrate-cofactor binding pocket; other site
880072008181	pyridoxal 5'-phosphate binding site [chemical binding]; other site
880072008182	catalytic residue [active]
880072008183	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
880072008184	dimer interface [polypeptide binding]; other site
880072008185	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806
880072008186	Protein of unknown function (DUF3379); Region: DUF3379; pfam11859
880072008187	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
880072008188	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
880072008189	putative dimer interface [polypeptide binding]; other site
880072008190	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
880072008191	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
880072008192	putative dimer interface [polypeptide binding]; other site
880072008193	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
880072008194	catalytic motif [active]
880072008195	Zn binding site [ion binding]; other site
880072008196	ribonuclease R; Region: RNase_R; TIGR02063
880072008197	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
880072008198	RNB domain; Region: RNB; pfam00773
880072008199	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
880072008200	RNA binding site [nucleotide binding]; other site
880072008201	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
880072008202	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
880072008203	putative active site [active]
880072008204	putative NTP binding site [chemical binding]; other site
880072008205	putative nucleic acid binding site [nucleotide binding]; other site
880072008206	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
880072008207	CRISPR-associated protein; Region: TIGR03986
880072008208	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl01634
880072008209	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
880072008210	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
880072008211	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
880072008212	CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558
880072008213	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
880072008214	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853
880072008215	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
880072008216	DHH family; Region: DHH; pfam01368
880072008217	DHHA1 domain; Region: DHHA1; pfam02272
880072008218	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
880072008219	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
880072008220	Ion channel; Region: Ion_trans_2; pfam07885
880072008221	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
880072008222	TrkA-N domain; Region: TrkA_N; pfam02254
880072008223	TrkA-C domain; Region: TrkA_C; pfam02080
880072008224	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
880072008225	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
880072008226	putative active site pocket [active]
880072008227	4-fold oligomerization interface [polypeptide binding]; other site
880072008228	metal binding residues [ion binding]; metal-binding site
880072008229	3-fold/trimer interface [polypeptide binding]; other site
880072008230	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
880072008231	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072008232	ATP binding site [chemical binding]; other site
880072008233	Mg2+ binding site [ion binding]; other site
880072008234	G-X-G motif; other site
880072008235	Response regulator receiver domain; Region: Response_reg; pfam00072
880072008236	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072008237	active site
880072008238	phosphorylation site [posttranslational modification]
880072008239	intermolecular recognition site; other site
880072008240	dimerization interface [polypeptide binding]; other site
880072008241	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
880072008242	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
880072008243	Zn2+ binding site [ion binding]; other site
880072008244	Mg2+ binding site [ion binding]; other site
880072008245	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
880072008246	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
880072008247	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
880072008248	pyruvate carboxylase subunit B; Validated; Region: PRK09282
880072008249	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
880072008250	active site
880072008251	catalytic residues [active]
880072008252	metal binding site [ion binding]; metal-binding site
880072008253	homodimer binding site [polypeptide binding]; other site
880072008254	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
880072008255	carboxyltransferase (CT) interaction site; other site
880072008256	biotinylation site [posttranslational modification]; other site
880072008257	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
880072008258	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
880072008259	acyl-activating enzyme (AAE) consensus motif; other site
880072008260	AMP binding site [chemical binding]; other site
880072008261	active site
880072008262	CoA binding site [chemical binding]; other site
880072008263	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
880072008264	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
880072008265	putative acyl-acceptor binding pocket; other site
880072008266	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
880072008267	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
880072008268	ATP binding site [chemical binding]; other site
880072008269	Mg2+ binding site [ion binding]; other site
880072008270	G-X-G motif; other site
880072008271	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
880072008272	Coenzyme A binding pocket [chemical binding]; other site
880072008273	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
880072008274	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
880072008275	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
880072008276	HlyD family secretion protein; Region: HlyD_3; pfam13437
880072008277	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
880072008278	FtsX-like permease family; Region: FtsX; pfam02687
880072008279	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
880072008280	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
880072008281	Walker A/P-loop; other site
880072008282	ATP binding site [chemical binding]; other site
880072008283	Q-loop/lid; other site
880072008284	ABC transporter signature motif; other site
880072008285	Walker B; other site
880072008286	D-loop; other site
880072008287	H-loop/switch region; other site
880072008288	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
880072008289	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
880072008290	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
880072008291	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
880072008292	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
880072008293	active site residue [active]
880072008294	Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746
880072008295	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
880072008296	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
880072008297	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
880072008298	metal binding site [ion binding]; metal-binding site
880072008299	substrate binding pocket [chemical binding]; other site
880072008300	putative formyltransferase; Provisional; Region: PRK06988
880072008301	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
880072008302	active site
880072008303	substrate binding site [chemical binding]; other site
880072008304	cosubstrate binding site; other site
880072008305	catalytic site [active]
880072008306	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
880072008307	active site
880072008308	hexamer interface [polypeptide binding]; other site
880072008309	NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908
880072008310	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
880072008311	NAD binding site [chemical binding]; other site
880072008312	substrate binding site [chemical binding]; other site
880072008313	active site
880072008314	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
880072008315	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
880072008316	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
880072008317	substrate binding site; other site
880072008318	dimer interface; other site
880072008319	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
880072008320	homotrimer interaction site [polypeptide binding]; other site
880072008321	zinc binding site [ion binding]; other site
880072008322	CDP-binding sites; other site
880072008323	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
880072008324	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
880072008325	FeS/SAM binding site; other site
880072008326	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
880072008327	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
880072008328	dimer interface [polypeptide binding]; other site
880072008329	putative functional site; other site
880072008330	putative MPT binding site; other site
880072008331	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
880072008332	rod shape-determining protein MreC; Provisional; Region: PRK13922
880072008333	putative transposase OrfB; Reviewed; Region: PHA02517
880072008334	Integrase core domain; Region: rve; pfam00665
880072008335	Integrase core domain; Region: rve_3; pfam13683
880072008336	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
880072008337	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
880072008338	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
880072008339	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
880072008340	Soluble P-type ATPase [General function prediction only]; Region: COG4087
880072008341	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
880072008342	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
880072008343	Soluble P-type ATPase [General function prediction only]; Region: COG4087
880072008344	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
880072008345	putative homodimer interface [polypeptide binding]; other site
880072008346	putative homotetramer interface [polypeptide binding]; other site
880072008347	putative allosteric switch controlling residues; other site
880072008348	putative metal binding site [ion binding]; other site
880072008349	putative homodimer-homodimer interface [polypeptide binding]; other site
880072008350	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
880072008351	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
880072008352	substrate binding site [chemical binding]; other site
880072008353	oxyanion hole (OAH) forming residues; other site
880072008354	trimer interface [polypeptide binding]; other site
880072008355	GTP-binding protein LepA; Provisional; Region: PRK05433
880072008356	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
880072008357	G1 box; other site
880072008358	putative GEF interaction site [polypeptide binding]; other site
880072008359	GTP/Mg2+ binding site [chemical binding]; other site
880072008360	Switch I region; other site
880072008361	G2 box; other site
880072008362	G3 box; other site
880072008363	Switch II region; other site
880072008364	G4 box; other site
880072008365	G5 box; other site
880072008366	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
880072008367	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
880072008368	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
880072008369	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
880072008370	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072008371	DNA methylase; Region: N6_N4_Mtase; cl17433
880072008372	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
880072008373	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665
880072008374	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
880072008375	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
880072008376	active site
880072008377	dimer interface [polypeptide binding]; other site
880072008378	effector binding site; other site
880072008379	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
880072008380	TSCPD domain; Region: TSCPD; pfam12637
880072008381	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
880072008382	Putative serine esterase (DUF676); Region: DUF676; pfam05057
880072008383	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
880072008384	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
880072008385	HlyD family secretion protein; Region: HlyD_3; pfam13437
880072008386	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
880072008387	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
880072008388	Walker A/P-loop; other site
880072008389	ATP binding site [chemical binding]; other site
880072008390	Q-loop/lid; other site
880072008391	ABC transporter signature motif; other site
880072008392	Walker B; other site
880072008393	D-loop; other site
880072008394	H-loop/switch region; other site
880072008395	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
880072008396	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
880072008397	Walker A/P-loop; other site
880072008398	ATP binding site [chemical binding]; other site
880072008399	Q-loop/lid; other site
880072008400	ABC transporter signature motif; other site
880072008401	Walker B; other site
880072008402	D-loop; other site
880072008403	H-loop/switch region; other site
880072008404	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
880072008405	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
880072008406	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
880072008407	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
880072008408	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
880072008409	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
880072008410	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
880072008411	Ligand binding site; other site
880072008412	Putative Catalytic site; other site
880072008413	DXD motif; other site
880072008414	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
880072008415	Putative zinc ribbon domain; Region: DUF164; pfam02591
880072008416	Uncharacterized conserved protein [Function unknown]; Region: COG0327
880072008417	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
880072008418	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
880072008419	Uncharacterized conserved protein [Function unknown]; Region: COG0327
880072008420	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
880072008421	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
880072008422	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
880072008423	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
880072008424	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
880072008425	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
880072008426	DNA binding residues [nucleotide binding]
880072008427	DNA primase, catalytic core; Region: dnaG; TIGR01391
880072008428	CHC2 zinc finger; Region: zf-CHC2; pfam01807
880072008429	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
880072008430	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
880072008431	active site
880072008432	metal binding site [ion binding]; metal-binding site
880072008433	interdomain interaction site; other site
880072008434	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
880072008435	MutS domain III; Region: MutS_III; pfam05192
880072008436	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
880072008437	Walker A/P-loop; other site
880072008438	ATP binding site [chemical binding]; other site
880072008439	Q-loop/lid; other site
880072008440	ABC transporter signature motif; other site
880072008441	Walker B; other site
880072008442	D-loop; other site
880072008443	H-loop/switch region; other site
880072008444	Smr domain; Region: Smr; pfam01713
880072008445	Yqey-like protein; Region: YqeY; pfam09424
880072008446	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
880072008447	Uncharacterized conserved protein [Function unknown]; Region: COG2454
880072008448	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
880072008449	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
880072008450	HSP70 interaction site [polypeptide binding]; other site
880072008451	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
880072008452	substrate binding site [polypeptide binding]; other site
880072008453	dimer interface [polypeptide binding]; other site
880072008454	Biotin operon repressor [Transcription]; Region: BirA; COG1654
880072008455	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
880072008456	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
880072008457	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
880072008458	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
880072008459	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
880072008460	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
880072008461	dimer interface [polypeptide binding]; other site
880072008462	conserved gate region; other site
880072008463	putative PBP binding loops; other site
880072008464	ABC-ATPase subunit interface; other site
880072008465	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
880072008466	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
880072008467	putative active site [active]
880072008468	PhoH-like protein; Region: PhoH; pfam02562
880072008469	Histidine carboxylase PI chain; Region: HDC; cl03540
880072008470	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
880072008471	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
880072008472	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
880072008473	GAF domain; Region: GAF; pfam01590
880072008474	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072008475	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
880072008476	putative active site [active]
880072008477	heme pocket [chemical binding]; other site
880072008478	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072008479	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
880072008480	putative active site [active]
880072008481	heme pocket [chemical binding]; other site
880072008482	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072008483	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
880072008484	putative active site [active]
880072008485	heme pocket [chemical binding]; other site
880072008486	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072008487	dimer interface [polypeptide binding]; other site
880072008488	phosphorylation site [posttranslational modification]
880072008489	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072008490	ATP binding site [chemical binding]; other site
880072008491	Mg2+ binding site [ion binding]; other site
880072008492	G-X-G motif; other site
880072008493	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
880072008494	FlhB HrpN YscU SpaS Family; Region: Bac_export_2; pfam01312
880072008495	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
880072008496	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
880072008497	ATP synthase subunit C; Region: ATP-synt_C; cl00466
880072008498	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
880072008499	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
880072008500	CoA binding domain; Region: CoA_binding; smart00881
880072008501	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
880072008502	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
880072008503	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
880072008504	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
880072008505	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
880072008506	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
880072008507	E3 interaction surface; other site
880072008508	lipoyl attachment site [posttranslational modification]; other site
880072008509	e3 binding domain; Region: E3_binding; pfam02817
880072008510	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
880072008511	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
880072008512	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072008513	active site
880072008514	phosphorylation site [posttranslational modification]
880072008515	intermolecular recognition site; other site
880072008516	dimerization interface [polypeptide binding]; other site
880072008517	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
880072008518	Walker A motif; other site
880072008519	ATP binding site [chemical binding]; other site
880072008520	Walker B motif; other site
880072008521	arginine finger; other site
880072008522	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
880072008523	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
880072008524	dimer interface [polypeptide binding]; other site
880072008525	Acylphosphatase; Region: Acylphosphatase; pfam00708
880072008526	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
880072008527	HypF finger; Region: zf-HYPF; pfam07503
880072008528	HypF finger; Region: zf-HYPF; pfam07503
880072008529	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
880072008530	HupF/HypC family; Region: HupF_HypC; pfam01455
880072008531	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
880072008532	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
880072008533	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
880072008534	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
880072008535	Major Facilitator Superfamily; Region: MFS_1; pfam07690
880072008536	putative substrate translocation pore; other site
880072008537	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
880072008538	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
880072008539	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
880072008540	putative active site [active]
880072008541	dimerization interface [polypeptide binding]; other site
880072008542	putative tRNAtyr binding site [nucleotide binding]; other site
880072008543	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
880072008544	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
880072008545	substrate binding site [chemical binding]; other site
880072008546	hexamer interface [polypeptide binding]; other site
880072008547	metal binding site [ion binding]; metal-binding site
880072008548	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
880072008549	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072008550	S-adenosylmethionine binding site [chemical binding]; other site
880072008551	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
880072008552	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
880072008553	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
880072008554	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
880072008555	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
880072008556	catalytic residue [active]
880072008557	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
880072008558	homodimer interface [polypeptide binding]; other site
880072008559	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
880072008560	active site pocket [active]
880072008561	diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830
880072008562	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
880072008563	active site
880072008564	ADP/pyrophosphate binding site [chemical binding]; other site
880072008565	dimerization interface [polypeptide binding]; other site
880072008566	allosteric effector site; other site
880072008567	fructose-1,6-bisphosphate binding site; other site
880072008568	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
880072008569	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
880072008570	active site
880072008571	HIGH motif; other site
880072008572	nucleotide binding site [chemical binding]; other site
880072008573	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
880072008574	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
880072008575	active site
880072008576	KMSKS motif; other site
880072008577	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
880072008578	tRNA binding surface [nucleotide binding]; other site
880072008579	anticodon binding site; other site
880072008580	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
880072008581	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
880072008582	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
880072008583	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
880072008584	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
880072008585	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
880072008586	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
880072008587	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
880072008588	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
880072008589	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
880072008590	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
880072008591	active site
880072008592	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
880072008593	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
880072008594	putative substrate binding region [chemical binding]; other site
880072008595	nif11 domain/cupin domain protein; Region: nif11_cupin; TIGR03890
880072008596	Cupin domain; Region: Cupin_2; cl17218
880072008597	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
880072008598	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
880072008599	catalytic core [active]
880072008600	Protein of unknown function DUF72; Region: DUF72; pfam01904
880072008601	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
880072008602	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
880072008603	substrate binding site [chemical binding]; other site
880072008604	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
880072008605	tartrate dehydrogenase; Region: TTC; TIGR02089
880072008606	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
880072008607	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
880072008608	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
880072008609	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
880072008610	S-adenosylmethionine binding site [chemical binding]; other site
880072008611	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
880072008612	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
880072008613	active site
880072008614	(T/H)XGH motif; other site
880072008615	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
880072008616	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
880072008617	ATP binding site [chemical binding]; other site
880072008618	putative Mg++ binding site [ion binding]; other site
880072008619	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
880072008620	nucleotide binding region [chemical binding]; other site
880072008621	ATP-binding site [chemical binding]; other site
880072008622	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
880072008623	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
880072008624	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
880072008625	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
880072008626	GIY-YIG motif/motif A; other site
880072008627	active site
880072008628	catalytic site [active]
880072008629	putative DNA binding site [nucleotide binding]; other site
880072008630	metal binding site [ion binding]; metal-binding site
880072008631	UvrB/uvrC motif; Region: UVR; pfam02151
880072008632	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
880072008633	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
880072008634	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
880072008635	catalytic residue [active]
880072008636	putative FPP diphosphate  binding site; other site
880072008637	putative FPP binding hydrophobic cleft; other site
880072008638	dimer interface [polypeptide binding]; other site
880072008639	putative IPP diphosphate binding site; other site
880072008640	ribosome recycling factor; Reviewed; Region: frr; PRK00083
880072008641	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
880072008642	hinge region; other site
880072008643	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
880072008644	putative nucleotide binding site [chemical binding]; other site
880072008645	uridine monophosphate binding site [chemical binding]; other site
880072008646	homohexameric interface [polypeptide binding]; other site
880072008647	elongation factor Ts; Reviewed; Region: tsf; PRK12332
880072008648	UBA/TS-N domain; Region: UBA; pfam00627
880072008649	Elongation factor TS; Region: EF_TS; pfam00889
880072008650	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
880072008651	rRNA interaction site [nucleotide binding]; other site
880072008652	S8 interaction site; other site
880072008653	putative laminin-1 binding site; other site
880072008654	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394
880072008655	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072008656	TPR repeat; Region: TPR_11; pfam13414
880072008657	binding surface
880072008658	TPR motif; other site
880072008659	TPR repeat; Region: TPR_11; pfam13414
880072008660	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072008661	binding surface
880072008662	TPR motif; other site
880072008663	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
880072008664	beta-ketothiolase; Provisional; Region: PRK09051
880072008665	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
880072008666	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
880072008667	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
880072008668	Protein phosphatase 2C; Region: PP2C; pfam00481
880072008669	active site
880072008670	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
880072008671	phosphopeptide binding site; other site
880072008672	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
880072008673	metal ion-dependent adhesion site (MIDAS); other site
880072008674	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
880072008675	phosphopeptide binding site; other site
880072008676	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
880072008677	Catalytic domain of Protein Kinases; Region: PKc; cd00180
880072008678	active site
880072008679	ATP binding site [chemical binding]; other site
880072008680	substrate binding site [chemical binding]; other site
880072008681	activation loop (A-loop); other site
880072008682	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072008683	binding surface
880072008684	Tetratricopeptide repeat; Region: TPR_16; pfam13432
880072008685	TPR motif; other site
880072008686	TPR repeat; Region: TPR_11; pfam13414
880072008687	Tetratricopeptide repeat; Region: TPR_16; pfam13432
880072008688	Tetratricopeptide repeat; Region: TPR_17; pfam13431
880072008689	TPR repeat; Region: TPR_11; pfam13414
880072008690	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072008691	binding surface
880072008692	TPR motif; other site
880072008693	TPR repeat; Region: TPR_11; pfam13414
880072008694	TPR repeat; Region: TPR_11; pfam13414
880072008695	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072008696	binding surface
880072008697	TPR motif; other site
880072008698	TPR repeat; Region: TPR_11; pfam13414
880072008699	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
880072008700	binding surface
880072008701	TPR motif; other site
880072008702	TPR repeat; Region: TPR_11; pfam13414
880072008703	TPR repeat; Region: TPR_11; pfam13414
880072008704	Uncharacterized conserved protein [Function unknown]; Region: COG3287
880072008705	FIST N domain; Region: FIST; pfam08495
880072008706	FIST C domain; Region: FIST_C; pfam10442
880072008707	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
880072008708	PAS fold; Region: PAS_3; pfam08447
880072008709	putative active site [active]
880072008710	heme pocket [chemical binding]; other site
880072008711	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
880072008712	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
880072008713	dimer interface [polypeptide binding]; other site
880072008714	phosphorylation site [posttranslational modification]
880072008715	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
880072008716	ATP binding site [chemical binding]; other site
880072008717	Mg2+ binding site [ion binding]; other site
880072008718	G-X-G motif; other site
880072008719	Response regulator receiver domain; Region: Response_reg; pfam00072
880072008720	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
880072008721	active site
880072008722	phosphorylation site [posttranslational modification]
880072008723	intermolecular recognition site; other site
880072008724	dimerization interface [polypeptide binding]; other site
880072008725	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
880072008726	AAA domain; Region: AAA_23; pfam13476
880072008727	Walker A/P-loop; other site
880072008728	ATP binding site [chemical binding]; other site
880072008729	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
880072008730	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
880072008731	active site
880072008732	metal binding site [ion binding]; metal-binding site
880072008733	valyl-tRNA synthetase-like protein; Provisional; Region: PTZ00419
880072008734	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
880072008735	Walker B; other site
880072008736	D-loop; other site
880072008737	H-loop/switch region; other site
880072008738	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
880072008739	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
880072008740	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
880072008741	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
880072008742	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
880072008743	non-specific DNA binding site [nucleotide binding]; other site
880072008744	salt bridge; other site
880072008745	sequence-specific DNA binding site [nucleotide binding]; other site
880072008746	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
880072008747	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
880072008748	DNA methylase; Region: N6_N4_Mtase; pfam01555
880072008749	Ion channel; Region: Ion_trans_2; pfam07885
880072008750	DNA repair protein RadA; Provisional; Region: PRK11823
880072008751	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
880072008752	Walker A motif/ATP binding site; other site
880072008753	ATP binding site [chemical binding]; other site
880072008754	Walker B motif; other site
880072008755	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
880072008756	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
880072008757	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
880072008758	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
880072008759	Coenzyme A binding pocket [chemical binding]; other site